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MedWorm: Ophthalmology



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Ophthalmology



Last Build Date: Mon, 28 Mar 2016 00:08:09 +0100

 



Lens density measurement with Scheimpflug camera in vitrectomised eyes.

Sun, 27 Mar 2016 12:37:02 +0100

CONCLUSIONS: The lens DOS in vitrectomised eyes is higher than in non-vitrectomised eyes. The importance of the vitreous in the maintenance of lens transparency is emphasised. PMID: 27012183 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)

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MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Ménard C, Rezende FA, Miloudi K, Wilson A, Tétreault N, Hardy P, SanGiovanni JP, De Guire V, Sapieha P Abstract Age-related macular degeneration (AMD) is a leading cause of blindness worldwide affecting individuals over the age of 50. The neovascular form (NV AMD) is characterized by choroidal neovascularization (CNV) and responsible for the majority of central vision impairment. Using non-biased microRNA arrays and individual TaqMan qPCRs, we profiled miRNAs in the vitreous humour and plasma of patients with NV AMD. We identified a disease-associated increase in miR-146a and a decrease in miR-106b and miR-152 in the vitreous humour which was reproducible in plasma. Moreover, miR-146a/miR-106b ratios discriminated patients with NV AMD with an area under the Receiver Oper...



Regulation of signaling events involved in the pathophysiology of neovascular AMD.

Sun, 27 Mar 2016 01:44:02 +0100

Authors: Wang H, Hartnett ME Abstract Neovascular age-related macular degeneration (AMD) is a complex disease in which an individual's genetic predisposition is affected by aging and environmental stresses, which trigger signaling pathways involving inflammation, oxidation, and/or angiogenesis in the RPE cells and choroidal endothelial cells (CECs), to lead to vision loss from choroidal neovascularization. Antiangiogenic therapies have greatly improved clinical outcomes in the last decade; however, vision improves in less than half of patients treated for neovascular AMD, and treatments remain inadequate for atrophic AMD. Many studies focus on genetic predisposition or the association of outcomes in trials of human neovascular AMD but are unable to evaluate the effects between diff...



VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1

Sat, 26 Mar 2016 23:00:00 +0100

Conclusions: Our results demonstrate that VIP’s therapeutic effect on HREC, occurs in part, through the balance between the pro-inflammatory cytokine, TNF-α, and the pro-resolving mediator, RvD1. Although VPAC1 is considered the major VIP receptor, VPAC2 is predominantly expressed on HREC under both normal and high glucose conditions. (Source: Prostaglandins and Other Lipid Mediators)



Photovoltaic Performance Photodiodes Based on Reduced Graphene Oxide-Fe3O4 and Carbon Nanotube-Fe3O4 Nanocomposites

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: 2016 Source:Materials Today: Proceedings, Volume 3, Issue 5 Author(s): İbrahim Karteri, Serhan Uruş, Halil Özerli, Şükrü Karataş We have studied photovoltaic performance photodiodes based on reduced graphene oxide-iron oxide (RGO-Fe3O4) and multi-wall carbon nanotube-iron oxide (MWCNT-Fe3O4) nanocomposites. Characterization of the RGO-Fe3O4 and the CNT-Fe3O4 nanostructures is investigated in detail by X-ray diffraction (XRD), FT-IR spectroscopy and scanning electron microscope (SEM). RGO is synthesized using modified Hummers’ method oxidation of graphite powder. The photovoltaic properties of the RGO-Fe3O4/p-Si/Al and the MWCNT-Fe3O4/p-Si/Al photodiodes are analyzed. The maximum electrical power values of devices were found to be 12.9μW and 10.4μW under 1...



Infliximab after Boston Keratoprosthesis in Stevens-Johnson Syndrome: An Update.

Sat, 26 Mar 2016 18:29:01 +0100

CONCLUSIONS: Intravenous infliximab may be considered as globe- and sight-saving therapy for tissue melt after B-KPro. PMID: 27015032 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Effect of Allergic Diseases on Keratoconus Severity.

Sat, 26 Mar 2016 18:29:01 +0100

CONCLUSIONS: Patients with VKC or AC were at increased risk of KC. They had more severe KC and should be closely followed up and intensively treated. PMID: 27014800 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



[In Process Citation].

Sat, 26 Mar 2016 17:56:02 +0100

Authors: Deutsche Ophthalmologische Gesellschaft, München PMID: 27011034 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)



[Change of Intraocular Pressure 10 Days Following Radical Prostatectomy for Prostate Cancer].

Sat, 26 Mar 2016 17:56:02 +0100

CONCLUSION: Our case series shows that there is a statistically significant decrease in IOP following RPE, and to a clinically relevant extent. The changes in PSA and IOP might be linked by changes in prostaglandin metabolism in the prostate and/or the seminal vesicles. This theory remains to be confirmed by further studies. The increase in IOP during the development of prostate cancer might also be linked to changes in prostaglandin metabolism and composition. It is conceivable that prostaglandin analogues could be developed to reduce IOP. PMID: 27011033 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)



[Causal Participation in Accident Assessment].

Sat, 26 Mar 2016 17:56:02 +0100

Authors: Burggraf MH Abstract A variety of different factors may participate in causing an accident or in influencing its course. These have different legal consequences in different areas of insurance. These differences are outlined for the assessment areas, together with the different states of evidence. In particular, it is discussed whether and under which conditions a trauma can indirectly (as a participating factor) either cause, trigger or exacerbate detachment of the retina. PMID: 27011032 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)

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[About the Effects of VEGF-A Antagonists on Molecular and Cellular Level].

Sat, 26 Mar 2016 17:56:02 +0100

This article therefore summarises the recent publications on this topic and discusses their relevance. Apart from common features such as VEGF-A affinity, the substances exhibit differences, including the stability of the VEGF-A/molecule complexes and the ability to neutralise angiogenic molecules other than only VEGF-A. At the cellular level, a variety of different methods have been used and the results are often inconsistent. It is therefore not yet possible to predict the clinical properties of VEGF-A neutralising substances on the basis of their known molecular properties or cellular effects. PMID: 27011031 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)



[Optic Disk Drusen: Historical and Up-To-Date Aspects].

Sat, 26 Mar 2016 17:56:02 +0100

Authors: Nentwich MM, Maertz J, Rudolph G Abstract Optic disc drusen are an important differential diagnosis in the diagnostic evaluation of a prominent optic nerve head. Drusen of the optic disc occur in 0.34 to 2.4 % of human individuals and manifest themselves bilaterally in three of four cases. Drusen are found six times more often within histological sections than on funduscopic examination. It is known that optic disc drusen can occur in familial clusters without any other pathological ophthalmic findings. They can also be associated with retinitis pigmentosa, or with the Joubert or Alagille syndromes. Non-invasive diagnostic tools include fundus-autofluorescence (AF), optical coherence tomography (OCT) and ultrasound. Drusen of the optic nerve head are asymptomatic in most...



[Muscular Dystrophies Involving the Retinal Function].

Sat, 26 Mar 2016 17:56:02 +0100

This article gives an overview of major muscular dystrophies involving retinal function and their genetic origin, in order to guide differential diagnosis. PMID: 27011029 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)



[Albinism and the Range of Fundus Hypopigmentation, Macular Hypoplasia, and Nystagmus].

Sat, 26 Mar 2016 17:56:02 +0100

Authors: Preising MN, Lorenz B Abstract From the ophthalmological view, albinism is a disorder of reduced pigmentation of the retinal and irdial pigment epithelium and the iris and choroid stroma. The reduced pigmentation is accompanied by morphological changes in the retina and the optic nerve. The functional relationship of these morphological changes is not yet well understood. This review summarises the genetic causes of reduced pigment synthesis and impaired pigment distribution, and discusses the variability of expression of albinism symptoms, in the light of other disorders affecting retinal development. PMID: 27011028 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)



[Ophthalmogenetics: Rare Diseases - A Challenge for Diagnostic and Treatment].

Sat, 26 Mar 2016 17:56:02 +0100

Authors: Rudolph G PMID: 27011027 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)



["There is nothing more constant than change" - Heraclitus 535 BC].

Sat, 26 Mar 2016 17:56:02 +0100

["There is nothing more constant than change" - Heraclitus 535 BC]. Klin Monbl Augenheilkd. 2016 Mar;232(3):241 Authors: Lang GK PMID: 27011026 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)

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Managing Primary Angle Closure Glaucoma - The Role of Lens Extraction in this Era.

Sat, 26 Mar 2016 17:54:02 +0100

Authors: Baig N, Kam KW, Tham CC Abstract Trabeculectomy has been the gold standard in reducing intraocular pressure (IOP) in glaucoma patients, no matter it is angle closure or open angle glaucoma. However in primary angle closure glaucoma, no matter the lens is cataractous or not, it is likely to be pathological, this thicker than usual lens, with or without a more anterior position, is often regarded as a strong contributing factor to angle closure. Lens extraction, no matter it is cataractous or clear, can theoretically eliminate this anatomical predisposing factor of angle closure, and thus IOP can be reduced. Based on recent results of a number of clinical trials, lens extraction alone or in combination with other IOP-lowering surgeries, may therefore play a more important ro...



Current and Future Techniques in Wound Healing Modulation after Glaucoma Filtering Surgeries.

Sat, 26 Mar 2016 17:54:02 +0100

Authors: Masoumpour MB, Nowroozzadeh MH, Razeghinejad MR Abstract Filtering surgeries are frequently used for controlling intraocular pressure in glaucoma patients. The long-term success of operation is intimately influenced by the process of wound healing at the site of surgery. Indeed, if has not been anticipated and managed accordingly, filtering surgery in high-risk patients could end up in bleb failure. Several strategies have been developed so far to overcome excessive scarring after filtering surgery. The principal step involves meticulous tissue handling and modification of surgical technique, which can minimize the severity of wound healing response at the first place. However, this is usually insufficient, especially in those with high-risk criteria. Thus, several adjuvan...



Current and Future of Laser Therapy in the Management of Glaucoma.

Sat, 26 Mar 2016 17:54:02 +0100

This article reviews the use of lasers in different areas of glaucoma, including the shift from argon laser trabeculoplasty (ALT) to selective laser trabeculoplasty (SLT), laser trabeculoplasty as an initial treatment for glaucoma, new laser trabeculoplasty procedures under investigation, and other recent laser treatment modalities such as endoscopic cyclophotocoagulation and laser-assisted deep sclerectomy. PMID: 27014388 [PubMed] (Source: Open Ophthalmology Journal)

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Detecting IOP Fluctuations in Glaucoma Patients.

Sat, 26 Mar 2016 17:54:02 +0100

Authors: Nuyen B, Mansouri K Abstract Lowering intraocular pressure (IOP) remains the guiding principle of glaucoma management. Although IOP is the only treatable risk factor, its 24-hour behavior is poorly understood. Current glaucoma management usually relies on single IOP measurements during clinic hours, even though IOP is a dynamic parameter with rhythms dependent on individual patients. It has further been shown that most glaucoma patients have their highest IOP measurements outside clinic hours. The fact that these IOP peaks go largely undetected may explain why certain patients progress in their disease despite treatment. Nevertheless, single IOP measurements have determined all major clinical guidelines regarding glaucoma treatment. Other potentially informative parameters...



Intra-Ocular Pressure Measurement in a Patient with a Thin, Thick or Abnormal Cornea.

Sat, 26 Mar 2016 17:54:02 +0100

This article reviews the various methods of intra-ocular pressure measurement available to the clinician and the ways in which their utility is influenced by variations in corneal thickness and biomechanics. PMID: 27014386 [PubMed] (Source: Open Ophthalmology Journal)



Editorial: Update on Glaucoma Diagnosis and Management.

Sat, 26 Mar 2016 17:54:02 +0100

Authors: Razeghinejad MR, Nowroozzadeh MH PMID: 27014385 [PubMed] (Source: Open Ophthalmology Journal)



A Case of Anterior Chamber Cholesterolosis Due to Coats' Disease and a Review of Reported Cases.

Sat, 26 Mar 2016 17:54:02 +0100

CONCLUSION: The presentation of anterior chamber cholesterolosis in Coats' disease can range from the incidental finding in an asymptomatic patient to acute angle closure glaucoma with pain and acutely decreased vision. Clinicians should be aware of this potential complication of Coats' disease as it denotes a poor visual prognosis. PMID: 27014384 [PubMed] (Source: Open Ophthalmology Journal)



Coats' Disease: Very Long-Term Outcome After Early Stage Conventional Treatment.

Sat, 26 Mar 2016 17:54:02 +0100

CONCLUSION: About three decades after conventional treatment of Coats' disease stage 2a, treated eyes maintained good VA, and stage 2b eyes did not progress to advanced stages. PMID: 27014383 [PubMed] (Source: Open Ophthalmology Journal)

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Retinopathy of Prematurity in Neonates and its Risk Factors: A Seven Year Study in Northern Iran.

Sat, 26 Mar 2016 17:54:02 +0100

CONCLUSION: The findings of current study demonstrate that the main risk factors of developing ROP in newborns are multiple gestation, low birth weight, oxygen therapy for more than five day. Therefore, the progression of ROP to blindness will be prevented by a high index of suspicion, suitable screening, prompt diagnosis, and early treatment. PMID: 27014382 [PubMed] (Source: Open Ophthalmology Journal)



The Effect of Intravitreal Azithromycin on the Albino Newborn Rabbit Retina.

Sat, 26 Mar 2016 17:54:02 +0100

CONCLUSION: In newborn rabbits, intravitreal azithromycin injection resulted in an apoptotic activity in the photoreceptor, bipolar and ganglion cells. Immunohistochemical analysis suggested that doses of 0.75 mg and 1.5 mg azithromycin, administered intravitreally might be toxic to the newborn rabbit retina. PMID: 27014381 [PubMed] (Source: Open Ophthalmology Journal)



Ocular, Neurologic and Systemic Findings of the Cases with Optic Nerve Hypoplasia.

Sat, 26 Mar 2016 17:54:02 +0100

CONCLUSION: The vision of young children with ONH should be monitored at least annually, and any refractive errors should be treated. Neuroimaging of the brain and endocrinologic evaluation is necessary in all cases with ONH. PMID: 27014380 [PubMed] (Source: Open Ophthalmology Journal)



Morphologic Changes in Patient with Drusen and Drusenoid Pigment Epithelial Detachment after Intravitreal Ranibizumab for Choroidal Neovascular Membrane : A Case Report.

Sat, 26 Mar 2016 17:54:02 +0100

Authors: Kim S, Oh J, Kim K Abstract The authors present a case of morphologic changes of drusen and drusenoid pigment epithelial detachment (DPED) after treating choroidal neovascularization (CNV) using ranibizumab in age-related macular degeneration (AMD). A 71-year-old woman has noticed mild visual acuity deterioration in the right eye for several months. She was presented with some drusen and DPED associated with CNV. This patient was given intravitreal injection of 0.5 mg of ranibizumab five times at monthly intervals for treating CNV. DPED in the temporal and drusen in the superior to macula were diminished, which continued up to 2 months. Intravitreal ranibizumab injection may have influenced with diminishment of drusen and DPED. After 2 months, CNV was recurred. PMID: ...



Color Doppler ultrasonography in the evaluation of compensatory arteries in patients with moyamoya disease: combined with cerebral angiography.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: Color duplex ultrasonography is a reliable, noninvasive and economic tool to assess hemodynamic changes of MA, STA and OA, and has prediction capability of these arteries formed compensatory arteries into intracranial. PMID: 27010154 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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The retinal nerve fiber layer, choroidal thickness, and central macular thickness in morbid obesity: an evaluation using spectral-domain optical coherence tomography.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: We have demonstrated by SD-OCT that morbid obesity may have a significant influence on RNFL, RGC, and CT. Morbid obesity may induce inflammatory, hormonal, and metabolic changes. PMID: 27010146 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Are our cornea waiting lists dynamic enough?

Sat, 26 Mar 2016 08:22:20 +0100

Abstract The purpose of this study was to evaluate the dynamic reality of the corneal transplant (CT) waiting list and if the CT candidates are really eager to operation. We evaluated the response of consecutive 96 CT candidates to call for operation. The age, functional visual acuity, CT indication, waiting period, and the excuse of refusal for candidates that postponed the operation were also evaluated. The patients were classified into two groups according to the availability (Group 1, available; Group 2, unavailable). To find an available candidate for transplantation of 48 consecutive corneal tissues, 96 patients had to be called. The mean age of the patients was 57.49 ± 18.75. The mean age of Group 1 and Group 2 was 54.28 ± 18.12 (13–80) and 60.44 ± 19.01 (9–88...



Treatment of massive subretinal hematoma associated with age-related macular degeneration using vitrectomy with intentional giant tear

Sat, 26 Mar 2016 08:22:20 +0100

This study involved 12 eyes of 12 patients (10 eyes: PCV, 2 eyes: ARMD). After removal of the lens in phakic eyes, we performed a vitrectomy with artificial posterior vitreous detachment. Subsequently, a 120° intentional giant retinal tear was created in the temporal periphery, the retina was then turned, and the subretinal hemorrhage and proliferative tissue were removed. In order to preserve as much of the retinal pigment epithelium (RPE) as possible, we used a bimanual technique under direct visualization. After stretching the retina by use of perfluorocarbon liquid (PFCL), we performed endophotocoagulation around the tear followed by PFCL/silicone oil exchange. Except for 1 eye in which extensive loss of the RPE occurred, the fundus findings and the visual acuity (VA) improved in all ...



A case–control study of post-traumatic endophthalmitis at a spanish hospital

Sat, 26 Mar 2016 08:22:20 +0100

Abstract Our aim was to identify the potential risk factors for developing post-traumatic endophthalmitis (PTE) and the possible measures of prevention. Retrospective case–control study, with 15 cases of PTE and 2 matched controls. We reviewed the medical records of the cases and their respective controls during the period 1996–2008 at a Spanish Hospital. We collected demographic data and information about the type of trauma, the potential risk factors, comorbidities, microbial isolations, antimicrobial susceptibility, administered treatments, and the visual outcome. The independent predictor factors identified for PTE were intraocular foreign body (IOFB) (OR 5.48; CI 95 % 1.05–28.7), dirty wound (OR 4.91; CI 95 % 0.96–25.3), and wound closure delays of 24 h or mor...



Monolayer MoS2/GaAs heterostructure self-driven photodetector with extremely high detectivity

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: May 2016 Source:Nano Energy, Volume 23 Author(s): Zhijuan Xu, Shisheng Lin, Xiaoqiang Li, Shengjiao Zhang, Zhiqian Wu, Wenli Xu, Yanghua Lu, Sen Xu Two dimensional material/semiconductor heterostructures offer alternative platforms for optoelectronic devices other than conventional Schottky and p–n junction devices. Herein, we use MoS2/GaAs heterojunction as a self-driven photodetector with wide response band width from ultraviolet to visible light, which exhibits high sensitivity to the incident light of 635nm with responsivity as 321mA/W and detectivity as 3.5×1013 Jones (Jones=cmHz1/2 W−1), respectively. Employing interface design by inserting h-BN and photo-induced doping by covering Si quantum dots on the device, the responsivity is increased to 419mA/...



Telemedical assessment of optic nerve head and retina in patients after recent minor stroke or TIA

Fri, 25 Mar 2016 23:00:00 +0100

Abstract The aim of the study is to telemedically assess the prevalence of simple optic nerve atrophy and retinal arteriolar anomalies in subjects who have had a minor stroke or TIA within 14 days, and to compare these results with an age-matched control group. By using a mobile examination unit, retinal photographs were taken with a 45° non-mydriatic colour fundus camera (KOWA NM-45, non-mydriatic-alpha) in patients who had suffered from a minor stroke or TIA within 14 days of the time of the examination. Retinal photographs were focused on the optic nerve head region. Pupils were not dilated. The documented medical history and the retinal images were stored on a server using browser independent web-based software running on PCs, tablets and smartphones. After completing the u...



Well: Fruits and Vegetables to Fight Cataracts

Fri, 25 Mar 2016 20:24:19 +0100

Here’s another reason to eat your veggies and fruits high in vitamin C: You may reduce your risk of vision loss from cataracts. (Source: NYT)



Retinal Thickness Changes and Hydroxychloroquine-related RetinopathyRetinal Thickness Changes and Hydroxychloroquine-related Retinopathy

Fri, 25 Mar 2016 19:09:17 +0100

Changes in the inner and outer retinal layer do not reliably signal the development of retinopathy in patients taking hydroxychloroquine (HCQ), according to a retrospective study. Reuters Health Information (Source: Medscape Medical News Headlines)



Bilateral retinal hemorrhages following finger pressure against the soft palate (الترفيع) in recessive CRB1-related retinopathy.

Fri, 25 Mar 2016 15:45:01 +0100

CONCLUSIONS: The traditional village therapy may have compromised retinal venous outflow and/or provoked a Valsalva phenomenon, leading to the bilateral retinal hemorrhages. The fact that this occurred bilaterally and in both sisters supports the concept of relative vessel wall incompetence as part of CRB1-related retinopathy. PMID: 27007588 [PubMed - as supplied by publisher] (Source: Ophthalmic Genetics)

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Antibiotics Side Effects on the Mitochondria

Fri, 25 Mar 2016 15:38:08 +0100

Science is just beginning to understand how important your mitochondria are to warding off the diseases of aging. And, as usual, mainstream medicine is lagging way behind. Along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are another key component of the anti-aging equation. You see, these tiny organelles in your cells are the power plants that turn fuel into energy for your body. Healthy mitochondria keep you young and energetic.  Research shows that damaged mitochondria can lead to: Schizophrenia and bipolar disorder; Alzheimer’s and Parkinson’s disease; Epilepsy, migraines, and nerve pain; Loss of muscle control and balance; Strokes, heart disease, and coronary artery disease; Chronic fatigue syndrome and fibromyalgia;...



OVS Announces

Fri, 25 Mar 2016 13:22:36 +0100

No abstract available (Source: Optometry and Vision Science)



Ready for a Revolution in Contact Lenses?

Fri, 25 Mar 2016 13:22:36 +0100

No abstract available (Source: Optometry and Vision Science)

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Revolutionary Future Uses of Contact Lenses

Fri, 25 Mar 2016 13:22:36 +0100

No abstract available (Source: Optometry and Vision Science)



Expert Views on Innovative Future Uses for Contact Lenses

Fri, 25 Mar 2016 13:22:36 +0100

ABSTRACT: Over the past 10 to 15 years, the availability of new materials and technologies has resulted in revolutionary concepts for contact lenses being proposed that go well beyond correcting vision. These novel uses include their prescribing to deliver topical ocular and systemic drugs, assist with ocular surface disease management, and limit the progression of myopia and novel methods to display visual information. How likely are these concepts to become commercially available, how successful will they be, and what are the potential issues to consider for them to come to market? To answer these questions, a panel of four experts were invited to discuss the benefits and pitfalls of these technologies and what challenges lay ahead of these concepts before their availability. Their respo...



The Future of Myopia Control Contact Lenses

Fri, 25 Mar 2016 13:22:36 +0100

ABSTRACT: The growing incidence of pediatric myopia worldwide has generated strong scientific interest in understanding factors leading to myopia development and progression. Although contact lenses (CLs) are prescribed primarily for refractive correction, there is burgeoning use of particular modalities for slowing progression of myopia following reported success in the literature. Standard soft and rigid CLs have been shown to have minimal or no effect for myopia control. Overall, orthokeratology and soft multifocal CLs have shown the most consistent performance for myopia control with the least side effects. However, their acceptance in both clinical and academic spheres is influenced by data limitations, required off-label usage, and a lack of clear understanding of their mechanisms fo...



Myopia Control with Bifocal Contact Lenses: A Randomized Clinical Trial

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions: The distance center bifocal contact lenses tested in this study achieved greater control over myopia progression and axial elongation (>70%) compared with most published results with multifocal spectacles. Further studies are warranted to identify the critical factors and mechanisms underlying this myopia control effect. (Source: Optometry and Vision Science)



Soft Contact Lenses with Positive Spherical Aberration for Myopia Control

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions: The soft contact lens with +SA slowed axial growth of the eye, although this did not translate into a sustained statistically significant effect on SECAR. The majority of the treatment effect occurred in the initial 6 months of wear. No evidence of rebound effect was observed after ceasing treatment. (Source: Optometry and Vision Science)

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In Vivo Studies Evaluating the Use of Contact Lenses for Drug Delivery

Fri, 25 Mar 2016 13:22:36 +0100

ABSTRACT: This review highlights the current state of knowledge of in vivo testing of drug-delivering contact lenses. There has been a significant increase in interest in alternative means to deliver ocular pharmaceuticals, and within the past few decades, contact lenses have emerged as a vehicle of interest because of their biocompatibility and acceptance by both eye care professionals and the public. Using techniques such as molecular imprinting, vitamin E diffusion barriers, ionic reservoirs, and drug-impregnated films, significantly improved drug release kinetics have been observed in vitro. Extension of these results into in vivo studies has thus far been limited but has led to evidence of the viability of this drug delivery platform by demonstrating improved drug residence time, drug...



Controlled Release of Multiple Therapeutics from Silicone Hydrogel Contact Lenses

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions: The results indicate use as daily disposable lenses for single day release or extended-wear lenses with multiple day release. Imprinted lenses are expected to lead to higher efficacy for patients compared to topical eye drops by improving compliance and mitigating concentration peaks and valleys associated with multiple drops. (Source: Optometry and Vision Science)



Release of Fluconazole from Contact Lenses Using a Novel In Vitro Eye Model

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions: Rapid drug release results from using a vial as the release system. Under low tear volume at physiological tear flow, commercial CLs can maintain a sustained drug release profile for up to 24 h. However, eyes with fungal keratitis may have increased tearing, which would significantly accelerate drug release. (Source: Optometry and Vision Science)



Photoprotection and Extended Drug Delivery by UV Blocking Contact Lenses

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions: The degradation of dexamethasone can be minimized by using a UV blocking contact lens or incorporating vitamin E into a non–UV blocking lens. Vitamin E incorporation has the dual benefits of improving drug stability and release profiles. (Source: Optometry and Vision Science)



Atropine and Roscovitine Release from Model Silicone Hydrogels

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions: Silicone hydrogel materials have the potential to deliver drugs for over 2 weeks without compromising lens properties. This could potentially overcome the need for regular drop instillation and allow for the maintenance of drug concentration in the tear film over the period of wear. This represents a potential option for treating a host of ophthalmic disorders in children including myopia and retinoblastoma. (Source: Optometry and Vision Science)

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Contact Lenses: A Delivery Device for Stem Cells to Treat Corneal Blindness

Fri, 25 Mar 2016 13:22:36 +0100

Worldwide, 45 million people are blind. Corneal blindness is a major cause of visual loss, estimated to affect 10 million. For the most difficult to treat patients, including those with a disease called limbal stem cell deficiency, a donor corneal graft is not a viable option; thus, patients are treated with specialized stem cell grafts, which fail in a significant proportion (30 to 50%) of subjects. This unacceptable failure rate means there is a pressing need to develop minimally invasive, long-lasting, cost-effective therapies to improve patient quality of life and lessen the economic burden. Restoring vision in patients with severe corneal disease is the main focus of our research program; however, to achieve our goals and deliver the best quality stem cell therapy, we must first under...



The Use of Contact Lenses as Biosensors

Fri, 25 Mar 2016 13:22:36 +0100

The tear film is a complex multilayer film consisting of various proteins, enzymes, and lipids and can express a number of biomarkers in cases of disease. The development of a contact lens sensor presents a noninvasive alternative for the detection and management of various diseases. Recent work has resulted in the commercialization of a device to monitor intraocular pressure for up to 24 h, and there are extensive efforts underway to develop a contact lens sensor capable of continuous glucose tear film monitoring to manage diabetes. This clinical perspective will highlight the major developments within this field and list some of the major challenges that still need to be addressed. (Source: Optometry and Vision Science)



Noninvasive Continuous Monitoring of Tear Glucose Using Glucose-Sensing Contact Lenses

Fri, 25 Mar 2016 13:22:36 +0100

This article reviews studies on ocular glucose and its monitoring methods as well as the attempts to continuously monitor the concentration of tear glucose by using contact lens–based sensors. (Source: Optometry and Vision Science)



Short-Term Visual Performance of Novel Extended Depth-of-Focus Contact Lenses

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions: When compared with AOP, EDOF lenses provide better intermediate and near vision performance in presbyopic participants without compromising distance vision. (Source: Optometry and Vision Science)



Red-Tinted Contact Lenses May Improve Quality of Life in Retinal Diseases

Fri, 25 Mar 2016 13:22:36 +0100

Conclusions Red-tinted contact lenses may dramatically improve visual functions, outdoor performance, and quality of life of patients suffering from retinal diseases. These lenses should be a part of the regular assessment in specialty clinics treating patients with low vision, glare, and photophobia. (Source: Optometry and Vision Science)

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In The News/New products

Fri, 25 Mar 2016 13:22:36 +0100

No abstract available (Source: Optometry and Vision Science)



Comparison of Peripapillary Choroidal Thickness Measurements via Spectral Domain Optical Coherence Tomography with and without Enhanced Depth Imaging.

Fri, 25 Mar 2016 13:00:02 +0100

CONCLUSIONS: The PP-CT measurements via SD-OCT without EDI were consistent with the measurements via SD-OCT with EDI. Ophthalmologists who do not have access to EDI technology can use images of SD-OCT without EDI to measure the peripapillary choroid for research purposes. However, thicker peripapillary choroids cannot be measured using this technique and require further modifications or newer technologies, such as SD-OCT with EDI. PMID: 27011108 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)



Aflibercept for Macular Edema Secondary to Central RVOAflibercept for Macular Edema Secondary to Central RVO

Fri, 25 Mar 2016 12:34:28 +0100

Aflibercept may be an effective therapeutic option for macular edema due to central retinal vein occlusion that did not respond to treatment with bevacizumab or ranibizumab. Eye (Source: Medscape Today Headlines)

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Antifungal potential of plant species from brazilian caatinga against dermatophytes.

Fri, 25 Mar 2016 12:16:02 +0100

This study evaluated the in vitro antidermatophytic activity of 23 crude extracts from nine plant species of semiarid vegetation (caatinga) found in Brazil. The extracts were tested at concentrations ranging from 1.95 to 1,000.0 mg/mL by broth microdilution assay against the reference strains T. rubrum ATCC 28189 and T. mentagrophytesATCC 11481, and 33 clinical isolates of dermatophytes. All plants showed a fungicidal effect against both fungal species, with MIC/MFC values of the active extracts ranging from 15.6 to 250.0 µg/mL. Selected extracts of Eugenia uniflora (AcE), Libidibia ferrea (AE), and Persea americana (AcE) also exhibited a fungicidal effect against all clinical isolates of T. rubrum and T. mentagrophytes complex. This is the first report of the antifungal activity of Schin...



Healthy Amount of Vitamin C Might Keep Cataracts at Bay

Fri, 25 Mar 2016 07:00:00 +0100

Title: Healthy Amount of Vitamin C Might Keep Cataracts at BayCategory: Health NewsCreated: 3/24/2016 12:00:00 AMLast Editorial Review: 3/25/2016 12:00:00 AM (Source: MedicineNet Eyesight General)



Occurrence of and Risk Factors for Ocular Hypertension and Secondary Glaucoma in Juvenile Idiopathic Arthritis-associated Uveitis.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: OHT and SG were common in patients with JIA-associated uveitis. Use of immunosuppressive drugs may decrease the risk of developing OHT. PMID: 27003850 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Adalimumab for Ocular Inflammation.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: Adalimumab was moderately effective in controlling inflammation in a group of highly pre-treated cases of ocular inflammatory disease. PMID: 27003323 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Why can’t I see after my heart is fixed: a case series of ocular complications after cardiac intervention

Fri, 25 Mar 2016 00:00:00 +0100

The purpose of this study was to report case series of retinal artery occlusion (RAO) as one of the significant complication post cardiac intervention. (Source: BMC Ophthalmology)



Surface Passivation of Lead Sulfide Nanocrystals with Low Electron Affinity Metals: Photoluminescence and Photovoltaic Performance

Thu, 24 Mar 2016 23:22:24 +0100

In this study, lead sulfide (PbS) CQDs were synthesized via hot...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)



[Perspective] Lead halides join the top optoelectronic league

Thu, 24 Mar 2016 23:00:00 +0100

In any solar cell that begins to approach the theoretical limits of performance, an intense internal luminescence photon gas must be present (see the figure) (1). On page 1430 of this is sue, Pazos-Outón et al. (2) provide evidence for such an internal photon gas in lead halide photovoltaic cells. These materials thus have properties similar to those of GaAs and have the potential to be among the top-performing solar cell materials. This is scientifically remarkable, because these compounds are the first high-quality halide semiconductors. The materials show promise for photovoltaics, light-emitting diodes (LEDs), laser refrigeration, thermophotonics, and a host of other major optoelectronic applications. Author: Eli Yablonovitch (Source: ScienceNOW)



Recent advances in laser in situ keratomileusis‐associated dry eye

Thu, 24 Mar 2016 23:00:00 +0100

This article reviews the recent studies of LASIK‐associated dry eye, including clinical features, aetiology, risk factors, evaluations and treatment. The applications of novel technologies in LASIK‐associated dry eye evaluation like anterior segment spectral‐domain optical coherence tomography (SD‐OCT) and corneal confocal microscopy are also introduced in this review. (Source: Clinical and Experimental Optometry)

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Diurnal variations in tear film break‐up time determined in healthy subjects by software‐assisted interpretation of tear film video recordings

Thu, 24 Mar 2016 23:00:00 +0100

ConclusionsTear film BUT was not influenced by the time of day and moderate to strong correlation with MBI was observed in all four sessions. The software‐assisted method proved useful and identified the need to clarify the BUT end‐point and to limit the test to 15 seconds to improve observer repeatability. (Source: Clinical and Experimental Optometry)



Accuracy of vision technicians in screening ocular pathology at rural vision centres of southern India

Thu, 24 Mar 2016 23:00:00 +0100

ConclusionAs there is good agreement between the vision technicians and the ophthalmologist for screening and referral of anterior segment pathology but moderate to fair for glaucoma suspects and retinal pathology, vision technicians would be a good resource at the primary level to screen for anterior segment pathology; however, they may need further training to detect posterior segment pathology. (Source: Clinical and Experimental Optometry)



Crizal Alize and Avance anti‐reflective coatings cause perceived rotational reversal of Haidinger's brushes

Thu, 24 Mar 2016 23:00:00 +0100

(Source: Clinical and Experimental Optometry)



Bilateral focal choroidal excavation in cone dystrophy

Thu, 24 Mar 2016 23:00:00 +0100

(Source: Clinical and Experimental Optometry)



Clinical Procedures in Primary Eye Care David B Elliot Elsevier Saunders 2014 318 pages, RRP: $84.95

Thu, 24 Mar 2016 23:00:00 +0100

(Source: Clinical and Experimental Optometry)

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Knowledge and professional activities

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: April–June 2016 Source:Journal of Optometry, Volume 9, Issue 2 Author(s): Miguel A. Teus (Source: Journal of Optometry)



Morphology controllable synthesis and characterization of gallium compound hierarchical structures via forced-hydrolysis method

Thu, 24 Mar 2016 23:00:00 +0100

We report the growth mechanism and formation of various morphological gallium precursors such as Ga4(OH)10SO4 nanospheres and ɑ-GaOOH microrods. The influence of the growth time on the crystal structure and its morphology was studied. The results indicate that the growth time played an important role in the transformation from amorphous to single-crystal structures. After calcination at 1000 °C for 1 h, well-crystallized and porous β-Ga2O3 microrods are formed. The enhanced broad blue emission of porous β-Ga2O3 microrods were related to defect band emission, such as oxygen vacancies and gallium-oxygen vacancy pairs. We propose that this oriented growth and transformation model may also be applicable to crystal growth and phase transformations and support the fabrication of other thre...



Anti-Human VEGF Repebody Effectively Suppresses Choroidal Neovascularization and Vascular Leakage

Thu, 24 Mar 2016 23:00:00 +0100

by Da-Eun Hwang, Jeong-Hyun Ryou, Jong Rok Oh, Jung Woo Han, Tae Kwann Park, Hak-Sung Kim Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness among people over the age of 60. Vascular endothelial growth factor (VEGF) plays a major role in pathological angiogenesis in AMD. Herein, we present the development of an anti- human VEGF repebody, which is a small-sized protein binder consisting of leucine-rich repeat (LRR) modules. The anti-VEGF repebody selected through a phage-display was shown to have a high affinity and specificity for human VEGF. We demonstrate that this repebody effectively inhibits in vitro angiogenic cellular processes, such as proliferation and migration, by blocking the VEGF-mediated signaling pathway. The repebody was also shown to ...

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Tuning photophysical properties and electronic energy levels of 1-aminoanthraquinone derivatives by introducing N-ethyl substituent

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: 15 July 2016 Source:Journal of Molecular Structure, Volume 1116 Author(s): Tianyang Wang, Haiya Sun, Ting Lu, Krithanthi C. Weerasinghe, Dongzhi Liu, Wenping Hu, Xueqin Zhou, Lichang Wang, Wei Li, Lizeng Liu It is proved that introducing the ethyl substituted group to 1-amino will enhance the intramolecular charge transfer (ICT) process of 1-N substituted anthraquinone derivatives. Bathochromic shift of the absorption maxima and diminished absorption intensity are observed with the increase of the electron donation abilities of the N-ethyl groups. Moreover, the intramolecular and intermolecular hydrogen bonds further intensify the ICT properties through introducing the end amino group. This work exhibits more effective acceptors than anthraquinone in novel mul...



Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: Available online 24 March 2016 Source:Neuron Author(s): Carsten Klein, Henry C. Evrard, Katharine A. Shapcott, Silke Haverkamp, Nikos K. Logothetis, Michael C. Schmid Electrical microstimulation and more recently optogenetics are widely used to map large-scale brain circuits. However, the neuronal specificity achieved with both methods is not well understood. Here we compare cell-targeted optogenetics and electrical microstimulation in the macaque monkey brain to functionally map the koniocellular lateral geniculate nucleus (LGN) projection to primary visual cortex (V1). Selective activation of the LGN konio neurons with CamK-specific optogenetics caused selective electrical current inflow in the supra-granular layers of V1. Electrical microstimulation targete...



AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: 24 March 2016 Source:Cell, Volume 165, Issue 1 Author(s): Sophie M. Steculorum, Johan Ruud, Ismene Karakasilioti, Heiko Backes, Linda Engström Ruud, Katharina Timper, Martin E. Hess, Eva Tsaousidou, Jan Mauer, Merly C. Vogt, Lars Paeger, Stephan Bremser, Andreas C. Klein, Donald A. Morgan, Peter Frommolt, Paul T. Brinkkötter, Philipp Hammerschmidt, Thomas Benzing, Kamal Rahmouni, F. Thomas Wunderlich, Peter Kloppenburg, Jens C. Brüning Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into ...



Genetic analysis of the aquaporin-4 gene for anti-AQP4 antibody-positive neuromyelitis optica in a Japanese population

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions These findings suggest that the T allele of rs2075575 is a risk for AQP4-Ab-positive NMO. However, the results are the opposite of a previous study in the southern Han Chinese population, and therefore further genetic studies are needed to determine the possible contribution of the AQP4 region to development of NMO. (Source: Japanese Journal of Ophthalmology)



Annular lesions and catenary forms in chronic central serous chorioretinopathy

Thu, 24 Mar 2016 23:00:00 +0100

To describe a series of patients exhibiting annular retinal pigment epithelial (RPE) lesions in the context of chronic central serous chorioretinopathy.Design; Retrospective comparative case series. (Source: American Journal of Ophthalmology)



The Role of Systemic Risk Factors in Diabetic Retinopathy

Thu, 24 Mar 2016 23:00:00 +0100

This article examines the existing literature on the links between glycemic control, arterial hypertension, high cholesterol and hyperlipidemia, obesity, inflammatory markers, sleep-disordered breathing, and exercise with risk of diabetic retinopathy development and prevention. The literature shows benefit for good glycemic and blood pressure control. The effects of cholesterol, and lipid control, inflammatory markers, sleep-disordered breathing, obesity, and exercise are less well established. (Source: Current Ophthalmology Reports)



A novel use of reticulated hyaluronic acid (Healaflow) for hypotony eyes in patients with uveitis.

Thu, 24 Mar 2016 23:00:00 +0100

We present the first case series, in which repeated intracameral injections of highly reticulated hyaluronic acid (Healaflow) have successfully prevented the complications of ocular hypotony in the long term. We believe it is a viable management option that can bring about a significant improvement to the quality of life in this subgroup of patients while avoiding frequent intervention. PMID: 27016504 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)

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Intraocular pressure elevation and choroidal thinning.

Thu, 24 Mar 2016 23:00:00 +0100

CONCLUSIONS: Choroidal thickness in the subfoveal region and in the peripapillary region decreased parallel to an acute increase in IOP in individuals 2 h after a dark room test. Choroidal thickness depends on the actual IOP, which may be noted when choroidal thickness is measured. PMID: 27016503 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)



Retinal Pigment Epithelial Cell Apoptosis is Influenced by a Combination of Macrophages and Soluble Mediators Present in Age-Related Macular Degeneration.

Thu, 24 Mar 2016 23:00:00 +0100

CONCLUSIONS: These findings indicate that microglia and macrophages are capable of enhancing the degeneration of RPE, which are crucial in AMD development. However this is dependent on the microenvironment present as AMD develops. PMID: 27015409 [PubMed - as supplied by publisher] (Source: Current Eye Research)



LumiThera wins Health Canada nod for photobiomodulation trial

Thu, 24 Mar 2016 21:14:23 +0100

LumiThera said today it won Health Canada approval for its Lightsite clinical trial examining the effect of its non-invasive photobiomodulation treatment in patients with age-related macular degeneration. The Seattle-based company’s study is being sponsored by a grant from the National Institute of Health and the division of the National Eye Institute. “The design of the study is to extend the previous clinical benefits in a double-masked, randomized, sham-controlled, parallel group study to assess the safety and efficacy of PBM in subjects with dry AMD. We believe this study will lay a solid foundation for the LumiThera device as a novel therapeutic approach to treating a very debilitating, degenerative ocular disease,” co-investigator Dr. Sam Markowitz said in prepared...



Medical management of glaucoma: focus on ophthalmologic drug delivery systems of timolol maleate.

Thu, 24 Mar 2016 17:20:02 +0100

Authors: Sah AK, Suresh PK Abstract Eye is a vital organ of our body and any complication not only poses the risk of serious medical condition but also economic burden on the individual. Timolol maleate is one of the preferable therapeutic agents for the management of glaucoma. Globally, eye drops are among the most common and popular conventional formulations, but they are also associated with some limitations in terms of therapeutic response, bioavailability, dosing frequency and poor patient compliance. Present paper gives an overview of the drug delivery systems developed for management of glaucoma, advances and novel approaches with special emphasis on timolol drug delivery. PMID: 27002850 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine and Biot...



Signs of hydroxychloroquine toxicity in a patient with rhegmatogenous retinal detachment.

Thu, 24 Mar 2016 12:47:01 +0100

DISCUSSION: SD-OCT could be used as a test in order to reveal HCQ toxicity in the event of retinal detachment. In this case, this technique shows abnormalities such as a hyper-reflective line in the outer retina layers. PMID: 27005921 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)



Subfoveal perfluorocarbon liquid. Removal after three months.

Thu, 24 Mar 2016 12:47:01 +0100

DISCUSSION: The elapsed time before subfoveal PFCL extraction seems to influence the visual result. There are other factors which could influence the final visual acuity significantly, nevertheless it is possible to achieve useful vision, as long as the fovea is not damaged and iatrogenic injuries are avoided during PFCL bubble extraction. PMID: 27005920 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)



Medical News Today: Vitamin C intake may help reduce the chance of cataracts

Thu, 24 Mar 2016 07:00:00 +0100

Cataracts are common in older age and are a major cause of blindness, but eating foods rich in vitamin C may slow or prevent the progress of the disorder. (Source: Health News from Medical News Today)

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The role of sub-retinal fluid in determining treatment outcomes in patients with neovascular age-related macular degeneration - a phase IV randomised clinical trial with ranibizumab: the FLUID study

Thu, 24 Mar 2016 00:00:00 +0100

With increasing experience using anti-VEGF therapy for the treatment of neovascular age-related macular degeneration (nAMD), ophthalmologists have shifted away from a “one size fits all” to an “individualised”... (Source: BMC Ophthalmology)



A Case of Intraocular Erosion and Intrusion by an Arruga Suture

Wed, 23 Mar 2016 23:23:24 +0100

Conclusion: In this study, we experienced a case of intraocular erosion and intrusion by an Arruga suture, and opted to treat the patient with steroid eye drops and conservative follow-up observations unless retinal redetachment and/or vitreous hemorrhage occurs.Case Rep Ophthalmol 2016;7:174-178 (Source: Case Reports in Ophthalmology)



A Case of Uveal Colobomas Showing Marked Left-Right Difference in Diabetic Retinopathy

Wed, 23 Mar 2016 23:23:24 +0100

Conclusion: Our findings show that the reason for the left-right difference in DR was attributed to the more severe choroidal coloboma and retinal thinning in the patient's right eye compared to his left eye, thus reducing oxygen demand, as is also seen in eyes with severe myopia.Case Rep Ophthalmol 2016;7:167-173 (Source: Case Reports in Ophthalmology)

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Treat and Extend versus Pro Re Nata regimens of ranibizumab in neovascular age‐related macular degeneration: a comparative 12 Month study

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionRanibizumab administered using a TE regimen in treatment‐naïve patients with nAMD provided better visual outcomes with fewer clinic visits, compared with a PRN regimen. (Source: Acta Ophthalmologica)



Novel PITX2 gene mutations in patients with Axenfeld‐Rieger syndrome

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionOur findings implicate a novel deletion of the PITX2 gene in the pathogenesis of ARS in the affected family. This ARS family presented with an atypical and extremely severe phenotype that resulted in four miscarriages and the death at 10 months of age of a sib of the proband. As the phenotypic manifestations in the proband are more severe than that of the father, we hypothesize that the deletion of the entire PITX2 allele plus a novel 2‐bp deletion (observed in the proband) within the remaining PITX2 allele together contributed to the atypical ARS presentation in this family. This is the first study reporting on bi‐allelic changes of PITX2 potentially contributing to a more severe ARS phenotype. (Source: Acta Ophthalmologica)



The vasodilating effects of insulin and lactate are increased in precapillary arterioles in the porcine retina ex vivo

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionThe diameter regulation in precapillary retinal arterioles differs from that of other retinal vascular branching levels and may play a special role in the pathophysiology of retinal vascular disease. (Source: Acta Ophthalmologica)






Lacrimal gland extranodal marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue‐type associated with massive amyloid deposition

Wed, 23 Mar 2016 23:00:00 +0100

(Source: Acta Ophthalmologica)

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The prognostic value of retinal vessel analysis in primary open‐angle glaucoma

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionThis longitudinal study did not find a general correlation between initial retinal vessel response to flicker light and the glaucoma damage progression measured by OCT and VF, hence limiting the relevance of the RVA device as a predictor of future glaucomatous damage. (Source: Acta Ophthalmologica)



What made you wait so long? Delays in presentation of retinal detachment: knowledge is related to an attached macula

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionMacula‐ON patients seem to self‐refer faster to a healthcare provider, seem more sensitive to floaters and seem more informed. This suggests that increasing awareness, especially about floaters, might increase the proportion of patients with macula still on at the moment of referral to the ophthalmologist. (Source: Acta Ophthalmologica)