Last Build Date: Tue, 22 Mar 2016 08:25:56 +0100
Mon, 21 Mar 2016 12:56:02 +0100CONCLUSIONS: The phacoemulsification combined with XEN45 implant surgery can effectively reduce IOP and the number of drugs in mild-moderate open-angle glaucoma, as they rehabilitate the VA. The use of only 2 micro-invasive incisions makes it simple, quick and safe, with few complications at 12 months follow-up from surgery. PMID: 26995503 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)
Mon, 21 Mar 2016 00:00:00 +0100Conclusions Compared to CPS, FLACS is a safer and more effective method for reducing endothelial cell loss and postoperative central corneal thickening as well as achieving better and faster visual rehabilitation and refractive outcomes. However, there is no difference in final CDVA and surgically induced astigmatism between the two groups. (Source: PLoS One)
Sun, 20 Mar 2016 18:17:02 +0100Authors: Lezrek O, Belhadj O, Jaja Z, Berradi S, Tachfouti S, Daoudi R PMID: 26987897 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Sat, 19 Mar 2016 19:30:02 +0100Conclusion. Both 3.0% diquafosol and 0.05% cyclosporine A were effective in treating dry eye after cataract surgery. Diquafosol was more effective in increasing the tear secretion, but cyclosporine A was more effective in improving optical aberrations. PMID: 26989503 [PubMed] (Source: Journal of Ophthalmology)
Sat, 19 Mar 2016 00:00:00 +0100Conclusions Combined modality treatment with R-MPV, binocular radiation, and high-dose cytarabine is effective with moderate toxicity. Both local and CNS relapses occur; however, the achievement of second and subsequent remissions is possible. (Source: Neuro-Oncology)
Sat, 19 Mar 2016 00:00:00 +0100To investigate if previous intravitreal therapy is a predictor of posterior capsule rupture (PCR) during cataract surgery. (Source: Ophthalmology)
Sat, 19 Mar 2016 00:00:00 +0100To evaluate how well partial coherence interferometry (PCI) (IOLMaster) and optical low-coherence reflectometry (OLCR) (Lenstar LS 900) predict postoperative refractions using only the formulas that come preinstalled on the machines. (Source: Journal of Cataract and Refractive Surgery)
Sat, 19 Mar 2016 00:00:00 +0100To compare the accuracy of the Barrett True-K formula with other methods available on the American Society of Cataract and Refractive Surgery (ASCRS) post-refractive surgery intraocular lens (IOL) power calculator for the prediction of IOL power after previous myopic laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK). (Source: Journal of Cataract and Refractive Surgery)
Sat, 19 Mar 2016 00:00:00 +0100A 71-year-old woman with Fuchs endothelial dystrophy in the right eye had uneventful phacoemulsification cataract surgery with implantation of a single-piece intraocular lens (IOL) (CT47S) in January 2012. Because of corneal problems and vision loss, uneventful Descemet-stripping automated endothelial keratoplasty (DSAEK) was performed in May 2013. Four months later, a new corneal lamella (repeat DSAEK) was implanted with reinjection of an air bubble into the anterior chamber. Six months after the initial DSAEK, the patient complained of blurred vision. (Source: Journal of Cataract and Refractive Surgery)
Sat, 19 Mar 2016 00:00:00 +0100We describe a technique to reposition a decentered 4-haptic intraocular lens (IOL). Using an ophthalmic viscosurgical device, the haptic with the worst distortion is dissected from the capsular bag and pulled outside the bag. The opposite haptic (180 degrees away) is also dissected and placed in front of the anterior capsule. The remaining 2 haptics are left in the capsular bag. With this repositioning, the 2 haptics in the bag limit the IOL movement, the 2 haptics outside the bag are no longer distorted, and the IOL is centered. (Source: Journal of Cataract and Refractive Surgery)
Sat, 19 Mar 2016 00:00:00 +0100The patient who cannot lie flat for cataract surgery presents a challenge.1 We have described face-to-face upright seated positioning for these patients,2,3 a technique we use most often for patients with fixed spinal deformity (kyphosis) and/or orthopnea. The surgeon sits or stands facing the erect or semi-recumbent patient and operates via an incision in the lower half of the cornea. The technique requires topical intracameral anesthesia, an adjustable surgical chair for the patient, and a microscope that rotates forward toward the horizontal. (Source: Journal of Cataract and Refractive Surgery)
Sat, 19 Mar 2016 00:00:00 +0100We present a case of CBS following penetrating keratoplasty (PKP) with cataract extraction and IOL implantation (triple procedure) that was diagnosed using anterior segment optical coherence tomography (AS-OCT). (Source: Journal of Cataract and Refractive Surgery)
Fri, 18 Mar 2016 12:34:34 +0100Conclusions: In routine practice, cytology of the vitreous fluid is performed in many and varied situations that are most often nonneoplastic. In nonneoplastic cases, cytology is a useful adjunct to vitrectomy, in spite of its limitations.Acta Cytologica (Source: Acta Cytologica)
Fri, 18 Mar 2016 00:00:00 +0100Conclusions In the current study, visual acuity outcomes were generally poor. Enterococcus and Staphylococcus species were the most common organisms reported and postoperative endophthalmitis after cataract surgery was the most common clinical setting. (Source: British Journal of Ophthalmology)
Fri, 18 Mar 2016 00:00:00 +0100Conclusions The use of a smaller needle in obtaining vitreous samples in endophthalmitis did not lower the microbiological yield. A positive microbiological yield was significantly less likely in cases of endogenous endophthalmitis compared with non-endogenous cases. Vitreous tap as a method for identifying the causative organism in endogenous endophthalmitis was of limited utility. (Source: British Journal of Ophthalmology)
Fri, 18 Mar 2016 00:00:00 +0100Conclusions There is sustained decrease in IOP after cataract extraction in non-glaucomatous eyes. This decrease is of greater magnitude in eyes with higher presurgical IOP and is not affected by the type of surgery performed. The effect of IOP decrease after surgery is unilateral and does not affect the fellow eye. (Source: British Journal of Ophthalmology)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion There was no significant difference in the average amount of apparent accommodation in pseudophakic eyes with refractive ATR, WTR and minimum astigmatism. However, the factors relevant to apparent accommodation varied depending on the status of postoperative refractive astigmatism. (Source: British Journal of Ophthalmology)
Fri, 18 Mar 2016 00:00:00 +0100Conclusions Inflammatory cytokines IL-1β, IL-6 and PGE2 significantly increased after femtosecond laser-assisted cataract surgery, which maybe the cause of intraoperative miosis seen in these patients. (Source: British Journal of Ophthalmology)
Fri, 18 Mar 2016 00:00:00 +0100This study is aimed to investigate the ocular findings in patients with Goltz syndrome. To date, there have been a limited number of case reports on the ocular manifestations of FDH. This is a prospective, non‐consecutive, observational case series. Prospective ophthalmologic evaluation was performed on 18 patients with confirmed genetic testing for FDH, Goltz Syndrome, as a component of a larger multi‐subspecialty study to better characterize the findings of this condition. Special attention was placed on evaluating the incidence of anophthalmia, microphthalmia, colobomas (iris, optic nerve, and/or retinal), cataracts, nystagmus, and strabismus. A complete ophthalmologic exam was done on all the patients. The mean patient age was 12.8 years (1–55 years). Eighty‐nine percent were f...
Fri, 18 Mar 2016 00:00:00 +0100ConclusionElevated postoperative IOP was observed in both treatment groups; however, bromfenac‐treated eyes were more likely to require intervention for elevated IOP. (Source: Veterinary Ophthalmology)
Fri, 18 Mar 2016 00:00:00 +0100Authors: Board PG, Menon D Abstract The Omega-class cytosolic glutathione transferases (GSTs) have distinct structural and functional attributes that allow them to perform novel roles unrelated to the functions of other GSTs. Mammalian GSTO1-1 has been found to play a previously unappreciated role in the glutathionylation cycle that is emerging as significant mechanism regulating protein function. GSTO1-1-catalyzed glutathionylation or deglutathionylation of a key signaling protein may explain the requirement for catalytically active GSTO1-1 in LPS-stimulated pro-inflammatory signaling through the TLR4 receptor. The observation that ML175 a specific GSTO1-1 inhibitor can block LPS-stimulated inflammatory signaling has opened a new avenue for the development of novel anti-inflammato...
Thu, 17 Mar 2016 01:39:38 +0100Special cells have a single copy of genome, like eggs and sperm, but can divide and form tissues in step towards pinpoint diagnosis of genetic disordersScientists for the first time have generated a type of embryonic stem cell that carries a single copy of the human genome rather than the usual two, a development that could advance research in gene editing, genetic screening and regenerative medicine. Related: Children with cataracts regain sight after radical stem cell treatment Continue reading... (Source: Guardian Unlimited Science)
Thu, 17 Mar 2016 00:00:00 +0100Authors: Nahomi RB, Pantcheva M, Nagaraj RH Abstract TGF-β2-mediated pathways play a major role in the epithelial to mesenchymal transition (EMT) of lens epithelial cells (LEC) during secondary cataract formation, which is also known as posterior capsule opacification (PCO). Although αB-crystallin is a major protein in LEC, its role in the EMT remains unknown. In a human lens epithelial cell line (FHL124) TGF-β2 treatment resulted in changes in the EMT-associated proteins at the mRNA and protein levels. This was associated with nuclear localization of αB-crystallin, phosphorylated Smad2 (pSmad2) (S245/250/255), pSmad3 (S423/425), Smad4 and Snail and the binding of αB-crystallin to these transcription factors, all of which were reduced by the downregulation of αB-crystallin. E...
Wed, 16 Mar 2016 19:40:02 +0100Conclusion. Intravitreal melphalan achieved a high local control rate for vitreous seeds without extraocular extension and with acceptable toxicity in Chinese retinoblastoma patients. PMID: 26977313 [PubMed] (Source: Journal of Ophthalmology)
Wed, 16 Mar 2016 07:35:03 +0100This study aimed to investigate whether the n-butanol extract of S. adoxoides (nSA) is effective against the H2O2-induced oxidative stress in human lens epithelial (HLE) cells. Materials and methods Human lens epithelial (SRA 01/04) cells were stimulated by H2O2 (250 μM) in the presence or absence of nSA. The antioxidant effects of nSA were determined in terms of cell viability (MTT assay), apoptosis (AnnexinV/PI staining), radical scavenging capability (various enzymatic assays), loss of mitochondrial membrane potential (Rhodamine 123 staining), expression of apoptotic markers including caspase-3 and caspase-9 and the change of Bcl-2/Bax ratio (western blot) in the HLE cells. Results The results showed that pretreatment of nSA (250, 500 and 1000 μg/mL) markedly reduced H2O2-induced ...
Wed, 16 Mar 2016 00:00:00 +0100Cataract is a multi-factorial disease that has been linked with both cardiovascular risk factors and increased mortality [1,2]. Cardiovascular risk factors associated with cataract and cataract surgery include hypertension , diabetes, high body mass index , and hypercholesterolemia . These associations strongly suggest that cataract may share similar underlying pathophysiological mechanisms an age-related disease such as cardiovascular disease. (Source: International Journal of Cardiology)
Wed, 16 Mar 2016 00:00:00 +0100Ophthalmologic manifestations of mitochondrial disorders are frequently neglected or overlooked because they are often not regarded as part of the phenotype. This review aims at summarizing and discussing the etiology, pathogenesis, diagnosis, and treatment of ophthalmologic manifestations of mitochondrial disorders. Review of publications about ophthalmologic involvement in mitochondrial disorders by search of Medline applying appropriate search terms. The eye is frequently affected by syndromic as well as nonsyndromic mitochondrial disorders. Primary and secondary ophthalmologic manifestations can be differentiated. The most frequent ophthalmologic manifestations of mitochondrial disorders include ptosis, progressive external ophthalmoplegia, optic atrophy, retinopathy, and cataract. Mor...
Wed, 16 Mar 2016 00:00:00 +0100ConclusionsIn the experimental group in this study, informative, educational and planned nursing care had a significant impact on anxiety levels in patients who had cataract surgery. Relevance to clinical practiceAlthough it is not implemented in most hospitals, and implementation in some hospitals is unplanned, systematically planned preoperative education should take place as part of standard nursing practices. (Source: Journal of Clinical Nursing)
Wed, 16 Mar 2016 00:00:00 +0100To report the incidence of acute postoperative endophthalmitis (POE) after cataract surgery from 2005 to 2014 in France. (Source: Ophthalmology)
Wed, 16 Mar 2016 00:00:00 +0100Cataract is a common cause of avoidable blindness in children globally. Gender differences in service access among children are reported for several conditions, but not for surgery for bilateral cataract. In this review we compared the proportion of children undergoing surgery for bilateral, nontraumatic cataract who were girls, using data from high-income, gender-neutral countries as the reference. (Source: Ophthalmology)
Wed, 16 Mar 2016 00:00:00 +0100CONCLUSIONS: Topical anaesthesia has shown a steady increase in usage and is the ideal anaesthesia, which has been associated with fewer complications. PMID: 26994109 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)
Wed, 16 Mar 2016 00:00:00 +0100In this study, we investigated the ability of DJ-1 to prevent protein glycation in keratinocytes. Glycation of collagen and keratinocyte proteins was tested by measuring ultraviolet absorption and fluorescence emission. Protein glycation in HaCaT keratinocytes was investigated by immunodetection with anti-advanced glycation endproduct antibodies, after DJ-1 depletion or overexpression. In vitro, DJ-1 prevented glycation of collagen and keratinocyte protein extracts. In cell culture, DJ-1 depletion by small interfering RNAs resulted in a 3-fold increase in protein glycation levels. Moreover, protein glycation levels were decreased several-fold in cells overexpressing DJ-1 after addition of the Nrf2 inducer sulforaphane or after transfection with a DJ-1 plasmid. Thus, the DJ-1 deglycase play...
Tue, 15 Mar 2016 21:23:34 +0100Scientists have described a cure for cataracts that involves regrowing the lens in the eye using stem cells. WebMD Health News (Source: Medscape Medical News Headlines)
Tue, 15 Mar 2016 11:19:22 +0100This article is protected by copyright. All rights reserved (Source: Journal of Cellular Physiology)
Tue, 15 Mar 2016 00:00:00 +0100(Source: Clinical and Experimental Ophthalmology)
Tue, 15 Mar 2016 00:00:00 +0100Conclusions Short-term statin use for primary prevention in this healthy cohort was associated with an increased risk of long-term diabetes and diabetic complications without cardiovascular benefits. Further study using pragmatic studies and prospective observational studies appropriately equipped to eliminate unidentified confounders are urgently needed. (Source: Drug Safety)
Tue, 15 Mar 2016 00:00:00 +0100Authors: Anand D, Lachke SA Abstract Over the past several decades, the biology of the developing lens has been investigated using molecular genetics-based approaches in various vertebrate model systems. These efforts, involving target gene knockouts or knockdowns, have led to major advances in our understanding of lens morphogenesis and the pathological basis of cataracts, as well as of other lens related eye defects. In particular, we now have a functional understanding of regulators such as Pax6, Six3, Sox2, Oct1 (Pou2f1), Meis1, Pnox1, Zeb2 (Sip1), Mab21l1, Foxe3, Tfap2a (Ap2-alpha), Pitx3, Sox11, Prox1, Sox1, c-Maf, Mafg, Mafk, Hsf4, Fgfrs, Bmp7, and Tdrd7 in this tissue. However, whether these individual regulators interact or their targets overlap, and the significance of su...
Mon, 14 Mar 2016 13:00:17 +0100Conclusions My shoulder is fine now, but it took weeks in a sling, months in physical therapy, and lots of exercises at home to get better. The fact is, I probably could have prevented the fall and shoulder injury I suffered last year if I’d paid more attention to the terrain and avoided tripping in the first place. But I have little doubt that my reaction time has slowed as I’ve gotten older. Is there anything I can do about that? Can we learn to hasten our reaction times or learn to “fall better”? I certainly hope so — for the sake of my own safety and the millions of others at risk of falling. Related Post:Balance training seems to prevent falls, injuries in seniorsFalling TVs injure 17,000 kids a yearThe gender gap in sports injuriesTwo questions can reveal mobility problems ...
Mon, 14 Mar 2016 00:00:00 +0100Conclusions Oral corticosteroid-related adverse events are common in severe asthma. New treatments which reduce exposure to oral corticosteroids may reduce the prevalence of these conditions and this should be considered in cost-effectiveness analyses of these new treatments. (Source: Thorax)
Mon, 14 Mar 2016 00:00:00 +0100ConclusionsThe extent to which the MGD grade was aggravated following cataract surgery differed based on preoperative MGD grade. Preoperative MGD and ocular surface status should be carefully evaluated. (Source: Clinical and Experimental Ophthalmology)
Mon, 14 Mar 2016 00:00:00 +0100(Source: Clinical and Experimental Ophthalmology)
Mon, 14 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved (Source: Journal of Bone and Mineral Research)
Mon, 14 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: Protein Science)
Mon, 14 Mar 2016 00:00:00 +0100CONCLUSIONS: The corneal sublayer thickness can be measured reliably using Cirrus HD-OCT in patients who underwent cataract surgery and elderly participants; however, the CET consistency is poorer than the NECCT. Corneal epithelial thickness modifications exceeding 4% reflect true thickness changes instead of random error variations using HD-OCT. PMID: 26980112 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Mon, 14 Mar 2016 00:00:00 +0100Authors: Subczynski WK, Mainali L, Raguz M, O'Brien WJ Abstract The plasma membrane together with the cytoskeleton forms the only supramolecular structure of the matured fiber cell which accounts for mostly all fiber cell lipids. The purpose of this review is to inform researchers about the importance of the lipid bilayer portion of the lens fiber cell plasma membranes in the maintaining lens homeostasis, and thus protecting against cataract development. PMID: 26988627 [PubMed - as supplied by publisher] (Source: Experimental Eye Research)
Sun, 13 Mar 2016 19:47:01 +0100Conclusion. Surgical and visual outcomes suggest hybrid 25-27-gauge vitrectomy combined with small incision phacoemulsification and IOL implantation is feasible, safe, and effective as a one-step surgical procedure for the management of vitreoretinal pathologies and concurrent cataract. PMID: 26966558 [PubMed] (Source: Journal of Ophthalmology)
Sun, 13 Mar 2016 10:27:01 +0100This article reviews ivacaftor safety. Areas covered: Safety findings in ivacaftor clinical trials, and reported subsequently, were accessed by a PubMed search using key words "VX-770" or "ivacaftor". Additional information was accessed via Google Search. Transaminitis was noted in ivacaftor and combination lumacaftor-ivacaftor trials. Ivacaftor was associated with cataracts in juvenile rat pups in pre-clinical studies; non-congenital cataracts have been found in children taking ivacaftor. Ivacaftor is a CYP3A substrate; CYP3A inhibitors and inducers should be avoided during its administration. Ivacaftor and its M1 metabolite may inhibit CYP3A and P-gp; therefore, ivacaftor may increase systemic exposure to drugs which are substrates of CYP3A and/or P-gp, increasing the potential for adver...
Sun, 13 Mar 2016 03:13:02 +0100CONCLUSIONS: Paintball trauma often results in significant ocular injury and loss of functional vision despite successful surgical intervention. Most injuries occur in under-supervised settings and are easily preventable. Improved safety measures, strict regulation enforcement and appropriate public education could prevent such serious damage. PMID: 26964276 [PubMed - in process] (Source: The Israel Medical Association Journal)
Fri, 11 Mar 2016 18:44:03 +0100Authors: Lezrek O, Boutimzine N, Daoudi C, Jaja Z, Belhadj O, Hafidi Z, Laghmari M, Daoudi R PMID: 26951871 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Fri, 11 Mar 2016 06:01:02 +0100CONCLUSIONS The caspase-3-dependent apoptosis of LECs increased in complicated cataract patients with SO endotamponade. The Bax played a critical role in regulating apoptosis of LECs in vitrectomized eyes with SO tamponade. The SO emulsification had no significant impact on the expression of apoptosis factors. PMID: 26956740 [PubMed - in process] (Source: Medical Science Monitor)
Fri, 11 Mar 2016 00:00:00 +0100Authors: Tjondro HC, Xi YB, Chen XJ, Su JT, Yan YB Abstract Vertebrate lens is one of the tissues with the highest soluble protein concentration. The predominant soluble proteins in lens fiber cells are crystallins, and among them, α-crystallins belong to the small heat shock protein family with chaperone-like activity. Although α-crystallins are highly soluble in waters, α-crystallins have been detected in the membrane-bound fraction of lens, which will increase in the aged or cataractous lens. In this research, we found αA-crystallin exhibited a complex thermal transition with remarkable changes in secondary and quaternary structures. Treatment of αA-crystallin at high temperatures induced larger oliogomers with higher hydrophobic exposure. Both heat-treated and untreated α...
Thu, 10 Mar 2016 12:00:00 +0100ConclusionThis is an exciting study, which shows that a new technique may be a much better alternative for treating babies born with congenital cataracts. It also suggests new ways for scientists to look at tissue regeneration from stem cells in the future.We now need to see the study repeated on a larger scale, to see if the initial results can be replicated. Only 12 children were treated with the new technique in this study, which is a very small set of results to rely on. We also need to see long-term follow up on these children, to find out how long the regenerated lenses continue to be free from cataracts. The suggestion that this treatment may also be suitable for adults should be treated with caution. As the researchers say, age-related cataracts are different from congenital catara...
Thu, 10 Mar 2016 11:00:00 +0100In a small trial, children in China born with cataracts regrew new eye lenses following surgery that removes diseased lenses but leaves lens capsules and own stem cells intact. (Source: Health News from Medical News Today)
Thu, 10 Mar 2016 07:00:00 +0100Title: Scientists Use Stem Cells to Correct Infant CataractsCategory: Health NewsCreated: 3/9/2016 12:00:00 AMLast Editorial Review: 3/10/2016 12:00:00 AM (Source: MedicineNet Eyesight General)
Thu, 10 Mar 2016 05:33:28 +0100Trial on babies and toddlers with congenital cataracts used stem cells to regenerate healthy lenses, producing better results than conventional surgeryA dozen infants who were born with cataracts have regained their sight after scientists used a radical new stem cell therapy to regenerate healthy lenses in their eyes.The children, all aged under two, are the first to receive the treatment for a condition that remains the most common cause of blindness in the world. Continue reading... (Source: Guardian Unlimited Science)
Thu, 10 Mar 2016 00:00:00 +0100Publication date: Available online 10 March 2016 Source:Medicina Author(s): Olga Sergejeva, Roman Botov, Rasa Liutkevičienė, Loresa Kriaučiūnienė Age-related macular degeneration (AMD) affects the macula and is the leading cause of significant and irreversible central visual loss. It is the most common cause of visual loss in people aged more than 60 years. This disease affects 2.5 million individuals in Europe. AMD is caused by both environmental and genetic factors. Numerous risk factors have been reported, but the pathogenesis of AMD is complex and fairly understood. Age, female gender, obesity, race, education status, family history, hyperopia, iris color, cigarette smoking, previous cataract surgery, history of cardiovascular and cerebrovascular disease, diabetes, sunlight ...
Thu, 10 Mar 2016 00:00:00 +0100The objective of this study was to observe the clinical features of patients with vernal keratoconjunctivitis attending the Outpatient Department of a mobile eye unit, Directorate of Health Services, Jammu and Kashmir over a period of 1 year. The greater prevalence of VKC is seen in the regions with hot, humid climate, and higher load of airborne allergens. The clinical profile of this disease seems to have geographical variation. The study was conducted in the mobile eye unit, Directorate of Health Services, Kashmir, a comparatively cooler area. All the patients with vernal keratoconjunctivitis who presented to the OPD during this period were examined. The diagnosis of vernal keratoconjunctivitis was based on typical history, clinical features, and examination. All the patients with the ...
Wed, 09 Mar 2016 23:20:44 +0100Using the body's own stem cells and a less invasive procedure, scientists help regrow lens cells in infant eyes (Source: Health News: CBSNews.com)
Wed, 09 Mar 2016 21:53:27 +0100The best treatment options for cataracts and corneal blindness today involve possibly risky surgical implants, but new research may point to the growing potential for less-invasive stem cell therapies. (Source: WSJ.com: Health)
Wed, 09 Mar 2016 20:19:19 +0100Conclusions: The chandelier-assisted bimanual technique is an effective method for dealing with adherent posterior hyaloid and epiretinal membranes in a detached retina, particularly in cases of complex open-funnel retinal detachment. Proper shaving of the anterior leaflet and refreshing the edges of the retinal break helps decrease postoperative PVR formation. Direct PFC-silicone oil exchange in giant retinal breaks helps minimize the risk of retinal slippage occurrence.Ophthalmologica (Source: Ophthalmologica)
Wed, 09 Mar 2016 20:17:01 +0100Leaving these cells behind during removal of damaged tissue led to regeneration of new, clear lens (Source: WebMD Health)
Wed, 09 Mar 2016 19:49:18 +0100Study found stem cells may help patients regenerate their lenses. (Source: ABC News: Health)
Wed, 09 Mar 2016 19:35:08 +0100Amy Norton, HealthDay News A new surgical technique for removing cataracts might allow the eye's stem cells to regenerate a healthy lens, if preliminary findings hold up. (Source: Health News - UPI.com)
Wed, 09 Mar 2016 19:00:00 +0100Leaving these cells behind during removal of damaged tissue led to regeneration of new, clear lens (Source: U.S. News - Health)
Wed, 09 Mar 2016 18:56:53 +0100Researchers have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses. (Source: ScienceDaily Headlines)
Wed, 09 Mar 2016 18:00:04 +0100Cataracts can be cured by regrowing the lens in the eye using stem cells, a breakthrough hailed as 'remarkable' by scientists (Source: Telegraph Health)
Wed, 09 Mar 2016 18:00:04 +0100Cataracts can be cured by regrowing the lens in the eye using stem cells, a breakthrough hailed as 'remarkable' by scientists (Source: Telegraph Health)
Wed, 09 Mar 2016 14:03:17 +0100WEDNESDAY, March 9, 2016 -- A new surgical technique for removing cataracts might allow the eye's stem cells to regenerate a healthy lens, if preliminary findings hold up. In an early study of infants born with cataracts, researchers used a... (Source: Drugs.com - Daily MedNews)
Wed, 09 Mar 2016 00:00:00 +0100This study demonstrated that the estimated annual eye lens dose is well below the revised ICRP’s limit of 20 mSv/year. However, we demonstrated high maximum and average doses during neuro-embolisation, cardiac ablation and vertebro-/kyphoplasty procedures. With radiation induced cataract being explained as a possible stochastic effect, without a threshold dose, anesthesiologists who regularly work in a radiological environment should remain vigilant and maintain radiation safety standards at all times. This includes adequately protective equipment (protection shields, apron, thyroid shield and leaded eye wear), keeping distance, routine monitoring and appropriate education. (Source: Journal of Clinical Monitoring and Computing)
Wed, 09 Mar 2016 00:00:00 +0100Conclusion The refractive and visual results of toric IOL implantation using the 3-point marking method were comparable to the other methods evaluated in this study, although the accuracy of the axis alignment of the toric IOLs was significantly lower than that obtained with the iris pattern method. (Source: Japanese Journal of Ophthalmology)
Wed, 09 Mar 2016 00:00:00 +0100Authors: Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A. J. Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen, Jiangna Chen, David Granet, Christopher Heichel, Fu Shang, Xuri Li, Michal Krawczyk, Dorota Skowronska-Krawczyk, Yujuan Wang, William Shi, Daniel Chen, Zheng Zhong, Sheng Zhong, Liangfang Zhang, Shaochen Chen, Sean J. Morrison, Richard L. Maas, Kang Zhang & Yizhi Liu The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. To our knowledge, human lens regeneration has not yet been demonstrated. Currently,...
Tue, 08 Mar 2016 08:28:17 +0100Seattle biotech Omeros closed 2015 with $13.5 million in revenue, $13.3 million of which came from sales of its first drug, Omidria, the company reported. For the fourth quarter, sales of Omidria totaled $6.7 million, or more than double third-quarter sales. The $6.7 million in sales revenue compares with grant revenue of $180,000 for the same quarter the prior year. Launched widely in the U.S. in April 2015, Omidria is a drug used during cataract surgery to maintain pupil size and reduce post-surgery… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Tue, 08 Mar 2016 07:21:26 +0100Conclusions: LCT proved to be the best option for treating corneal thinning. AMT represents an alternative that allows good visual recovery but does not restore corneal thickness as efficiently as LCT. (Source: Cornea)
Tue, 08 Mar 2016 07:21:26 +0100Conclusions: DMD can occur after femtosecond laser-assisted cataract surgery, although it is a rare complication as it is in traditional phacoemulsification. The surgeon must be prepared to recognize it, manage it intraoperatively, and treat it postoperatively to reduce the risk of permanent damage to the eye. (Source: Cornea)
Mon, 07 Mar 2016 23:23:12 +0100Many patients who get lens implant surgery to correct vision problems may develop cataracts or elevated pressure around the eyes within 10 years after the procedures, a Swiss study suggests. Reuters Health Information (Source: Medscape Ophthalmology Headlines)
Mon, 07 Mar 2016 00:00:00 +0100The potential for eyes after cataract surgery to have an increased risk of progression of age-related macular degeneration (AMD) has long been of concern.1 We previously reported 3-year follow-up findings from the Australian Cataract Surgery and Age-related Macular Degeneration (CSAMD) study showing no increased incidence of early or late AMD in eyes 3 years after surgery, compared with nonoperated fellow eyes of the same patients.2 A recent 20-year follow-up report from the Beaver Dam Eye Study (BDES) once again confirmed that cataract surgery was associated with an increased incidence of late but not early AMD over the long-term. (Source: Ophthalmology)
Mon, 07 Mar 2016 00:00:00 +0100Chung-Hwan Kim, Ungsoo Samuel KimIndian Journal of Ophthalmology 2016 64(1):91-92A 67-year-old woman complained of horizontal diplopia shortly following bilateral cataract surgery with intraocular lens implantation performed under retrobulbar anesthesia. Retrobulbar anesthesia was administered at an inferotemporal injection site using 1 cc lidocaine hydrochloride 2% mixed with bupivacaine hydrochloride 0.5%. The initial ophthalmologic evaluation showed a 12-prism diopter (PD) exotropia, and ocular motility evaluation revealed marked limitation of adduction without vertical limitation. One year after cataract surgery, the exodeviation increased up to 60 PD. The patient underwent an 8.0-mm recession of the right lateral rectus and a 6.0-mm recession of the left lateral ...
Sun, 06 Mar 2016 23:34:32 +0100BACKGROUND: There is increasing evidence that visual impairment contribute to falling. The aim of this study was to determine the influence of vision impairment of old adult patients with cataract on the occurrence of falls and postural control. ME... (Source: SafetyLit)
Sun, 06 Mar 2016 13:44:01 +0100CONCLUSIONS: The POAG patients have a PEROX background that is reflected in the aqueous humor by variations in MDA/TBARS and AAO. Moreover, both the MDA/TBARS and AAO correlated with IOP values and the CDR. We propose that determination of MDA/TBARS and AAO in the aqueous humor of POAG patients can be used as biomarkers for monitoring the disease, as well the changes in lifestyle and other related risk factors. PMID: 26944209 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)
Sun, 06 Mar 2016 08:15:02 +0100Conclusions. High myopia is a risk factor for capsular contraction syndrome. Elevated TGF-β2 levels in high myopic cataract patients may play an important role in the pathogenesis of capsular contraction syndrome. PMID: 26942002 [PubMed] (Source: Journal of Ophthalmology)
Sun, 06 Mar 2016 00:00:00 +0100(Source: Clinical and Experimental Ophthalmology)
Sat, 05 Mar 2016 05:19:21 +0100No abstract available (Source: International Ophthalmology Clinics)
Sat, 05 Mar 2016 00:00:00 +0100The purpose of this study was to evaluate the effects of cataracts on the flicker electroretinograms (ERGs) recorded with the RETeval™ system under mydriatic-free conditions. (Source: BMC Ophthalmology)
Fri, 04 Mar 2016 21:40:56 +0100(Reuters Health) - Many patients who get lens implant surgery to correct vision problems may develop cataracts or elevated pressure around the eyes within 10 years after the procedures, a Swiss study suggests. (Source: Reuters: Health)
Fri, 04 Mar 2016 00:00:00 +0100Conclusion Cerebrotendinous xanthomatosis is a progressive and preventable disorder and it benefits from therapy, so early diagnosis is mandatory to prevent significant morbidity and mortality associated with this disease. (Source: Journal of Clinical Orthopaedics and Trauma)
Fri, 04 Mar 2016 00:00:00 +0100CONCLUSION: The graded system resulted in no major complications and a low rate of minor complications. The information obtained from the mandatory assessment is unlikely to prevent complications. Additionally, the cost effectiveness of the mandatory system was poor. This novel graded preoperative assessment system for cataract surgery patients can save time and resources by eliminating unnecessary patient visits. PMID: 26943645 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Fri, 04 Mar 2016 00:00:00 +0100The objective of this study was to characterize auditory and other phenotypes of patients with MYH9 disorder. We examined nine subjects from one Japanese family. Audiological, ophthalmological, hematological, and imaging examinations were used to assess clinical features. We carried out genetic analysis of the causative gene, MYH9. Five subjects exhibited macrothrombocytopenia and neutrophil cytoplasmic inclusion bodies. Immunofluorescence analysis of neutrophil NMMHC-IIA revealed abnormal type II localization. Two subjects had high-frequency dominant hearing loss, which was adult onset and progressive. Only one subject had cataract. MYH9 sequencing analysis of all thrombocytopenic subjects revealed a heterozygous c.4270G>A mutation in exon 30 (p.D1424N). We identified five patients wit...
Fri, 04 Mar 2016 00:00:00 +0100CONCLUSIONS: Hypoparathyroidism is often associated with complications and comorbidities. It is important for endocrinologists and other physicians who care for these patients to be aware of recent advances in the epidemiology, diagnosis and genetics of this disorder. PMID: 26943720 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Thu, 03 Mar 2016 00:00:00 +0100Conclusion: In this patient, rituximab was a well-tolerated and effective remission induction agent for severe refractory Wegener’s granulomatosis and led to successful cataract surgery. (Source: Saudi Journal of Ophthalmology)
Thu, 03 Mar 2016 00:00:00 +0100Conclusions PHACO surgery combined with IVTA injection improves BCVA and provides a decrease in CMT in diabetic patients with CSME. Additional macular grid laser photocoagulation after surgery helps to preserve this improvement in BCVA and decrease in CMT. (Source: Saudi Journal of Ophthalmology)
Thu, 03 Mar 2016 00:00:00 +0100Conclusions Surgeons tended to select IOL implantation, rather than to leave the eye aphakic, in patients who were older at the time of surgery, had fewer coexisting ocular disorders, and suffered from unilateral cataract. Under such circumstances, pseudophakic eyes obtained significantly better postoperative visual acuity than did aphakic eyes. (Source: Japanese Journal of Ophthalmology)
Wed, 02 Mar 2016 00:00:00 +0100Abstract Endophthalmitis is an intraocular inflammatory condition which may or may not be caused by infective agents. Noninfectious (sterile) endophthalmitis may be attributable to various causes including postoperative retained soft lens matter or toxicity following introduction of other agents into the eye. Infectious endophthalmitis is further subdivided into endogenous and exogenous. In endogenous endophthalmitis there is hematogenous spread of organisms from a distant source of infection whereas in exogenous endophthalmitis direct microbial inoculation may occur usually following ocular surgery or penetrating eye injury with or without intraocular foreign bodies. Acute infective endophthalmitis is usually exogenous induced by inoculation of pathogens following ocular surgery,...
Wed, 02 Mar 2016 00:00:00 +0100Conclusions The oblique astigmatism (Z 2 −2 ) of the total cornea significantly changed after 2.2-mm-incision cataract surgery. The changes in the lower- and higher-order aberrations of the anterior cornea mainly contributed to the changes in the total cornea. (Source: Japanese Journal of Ophthalmology)
Wed, 02 Mar 2016 00:00:00 +0100Authors: Rowan S, Chang ML, Reznikov N, Taylor A Abstract The eye lens is unique among tissues: it is transparent, does not form tumors, and the majority of its cells degrade their organelles, including their cell nuclei. A mystery for over a century, there has been considerable recent progress in elucidating mechanisms of lens fiber cell denucleation (LFCD). In contrast to the disassembly and reassembly of the cell nucleus during mitosis, LFCD is a unidirectional process that culminates in destruction of the fiber cell nucleus. Whereas p27(Kip1), the cyclin-dependent kinase inhibitor, is upregulated during formation of LFC in the outermost cortex, in the inner cortex, in the nascent organelle free zone, p27(Kip1) is degraded, markedly activating cyclin-dependent kinase 1 (Cdk1). T...
Tue, 01 Mar 2016 06:00:00 +0100Purpose: To compare the outcomes of cataract surgery alone versus combined cataract surgery with trabeculectomy in eyes with phacomorphic glaucoma. Materials and Methods: In a retrospective comparative case series, 126 eyes of phacomorphic glaucoma presenting within 4 weeks of onset between 1993 and 2012, with at least 6 months of postoperative follow-up were included. Group 1 included 63 eyes with cataract surgery only and group 2 included 63 eyes with combined cataract surgery and trabeculectomy. Primary outcome measure was intraocular pressure (IOP) ≤21 mm Hg (without antiglaucoma medication) 6 months after surgery. Results: The median (interquartile range) preoperative IOP in group 1 was 36 mm Hg (30 to 50 mm Hg) and group 2 was 40 mm Hg (32 to 48 mm Hg) (P=0.34). The median durati...
Tue, 01 Mar 2016 06:00:00 +0100Conclusions: Among patients with incident glaucoma, no major factors were associated with change in physical well being. However, compared with medical treatment only, a history of laser trabeculoplasty, which was commonly accompanied with a history of medical treatment and likely represented the need for a second line of treatment, was associated with a worse decline in mental well being. (Source: Journal of Glaucoma)
Tue, 01 Mar 2016 06:00:00 +0100A young patient presented with visual acuity of hand movements only, unrecordable intraocular pressure, and total cataract after trauma 12 months ago. She reported failure to improve with conservative therapy as well as a direct cycloplexy elsewhere. After cleft localization on preoperative gonioscopy, ultrasound biomicroscopy (UBM), and intraoperative gonioscopy, a partial-thickness scleral flap was fashioned at the site of maximum cleft height. Following phacoaspiration, a multipiece intraocular lens was implanted in the sulcus; its haptics aligned to the axis with maximum height of cyclodialysis. A Cionni ring placed in sulcus was sutured to sclera under the flap to provide additional tamponading effect. Postoperative UBM and gonioscopy confirmed cleft closure. Normalization of intraocu...
Tue, 01 Mar 2016 06:00:00 +0100This study is a cross-sectional study that was approved by the institutional review board of Zhongshan Ophthalmic Center of Sun Yat-sen University in Guangzhou, China. Digital coaxial retro-illumination photographs of 329 aphakic pediatric eyes were obtained 12 months after pediatric cataract surgery without intraocular lens implantation. Capsule digital coaxial retro-illumination photographs were divided as follows: anterior capsule opening area (ACOA), posterior capsule opening area (PCOA), and posterior capsule opening opacity (PCOO). Capsular outcomes were qualitatively classified into 3 types based on the PCOO: Type I—capsule with mild opacification but no invasion into the capsule opening; Type II—capsule with moderate opacification accompanied by contraction of the ACOA and inv...
Tue, 01 Mar 2016 06:00:00 +0100Abstract: The prevalence of blindness increases rapidly with increasing age. Globally, there are some 32 million people who are blind and 191 million with poor vision. The leading cause of blindness worldwide is cataract, whereas uncorrected refractive error causes most poor vision. The rates of blindness from diabetes and macular degeneration are rapidly increasing, and age-related macular degeneration is the leading cause of blindness in developed countries. Three quarters of this blindness can be prevented or treated, and although the absolute number of blind people increased slightly between 1990 and 2010, very importantly, the prevalence of blindness has been halved as eye care programs and particularly cataract services have developed. We know how to deliver better eye care, and it w...
Tue, 01 Mar 2016 06:00:00 +0100Conclusions: In our study, the addition of antibiotic eye drops before cataract surgery and perioperative cleansing with 10% povidone-iodine were effective means to reduce the incidence of postoperative endophthalmitis. (Source: Asia-Pacific Journal of Ophthalmology)