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MedWorm: Aphasia



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Aphasia category.



Last Build Date: Sun, 20 Mar 2016 16:54:42 +0100

 



The phenotypical core of Alzheimer-related and nonrelated variants of the corticobasal syndrome: A systematic clinical, neuropsychological, imaging, and biomarker study.

Sat, 19 Mar 2016 16:29:02 +0100

DISCUSSION: CBS is primarily a "motor-plus-aphasia" disease unfolding into AD-related and non-AD-related variants with distinctive cognitive-anatomic patterns. CBS, and notably its "Gerstmann variant", should be included in the new AD "lexicon" and categorized in the evolving diagnostic spectrum of "atypical AD"d. PMID: 26988428 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)

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Phase 2 study of the bispecific T-cell engager (BiTE) antibody blinatumomab in relapsed/refractory diffuse large B-cell lymphoma

Thu, 17 Mar 2016 00:00:00 +0100

Few patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) achieve prolonged disease-free survival. Blinatumomab, a bispecific T-cell engaging antibody construct, transiently links CD3-positive T cells to CD19-positive B cells. This phase 2 study evaluated stepwise (9-28-112 μg/d with weekly dose increases; n = 23) or flat (112 μg/d; n = 2) dosing of blinatumomab by continuous infusion, with dexamethasone prophylaxis, in patients with relapsed/refractory DLBCL. Patients received a median of 3 prior lines of therapy. Median time since last regimen was 1.5 months. Seventeen patients ended treatment in cycle 1 (induction), 7 in cycle 2 (consolidation), and 1 in retreatment. Among 21 evaluable patients, the overall response rate after 1 blinatumomab cycle was 43%, includ...



The Relationship between Frontotemporal Effective Connectivity during Picture Naming, Behavior, and Preserved Cortical Tissue in Chronic Aphasia

Wed, 16 Mar 2016 22:35:05 +0100

Erin L. Meier, Kushal J. Kapse, Swathi Kiran (Source: Frontiers in Human Neuroscience)



Electrophysiological indices of brain activity to content and function words in discourse.

Tue, 15 Mar 2016 00:00:00 +0100

CONCLUSIONS & IMPLICATIONS: The results of this study support the view that the right LAP is an index of general discourse processing rather than an index of word class. These findings demonstrate that the LAP can be used to study discourse processing in populations with compromised metalinguistic skills, such as adults with aphasia or traumatic brain injury. PMID: 26992119 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)



Research Offers Clues to Dementia with Language Loss

Sun, 13 Mar 2016 13:00:00 +0100

In this rarer form of brain illness, protein plaques appear to clump more prominently in certain areas Source: HealthDay Related MedlinePlus Pages: Alzheimer's Disease, Aphasia, Dementia (Source: MedlinePlus Health News)



Protocol Based Real-Time Continuous Electroencephalography for Detecting Vasospasm in Subarachnoid Hemorrhage.

Sat, 12 Mar 2016 07:19:02 +0100

We describe a patient with an aneurysmal SAH whose symptomatic vasospasm was detected promptly by using a real-time cEEG. Patient was immediately treated by intraarterial vasodilator therapy. A 50-year-old woman without any significant medical history presented with a severe bifrontal headache due to acute SAH with a ruptured aneurysm on the anterior communicating artery (Fisher grade 3). On bleed day 6, she developed a sudden onset of global aphasia and left hemiparesis preceded by cEEG changes consistent with vasospasm. A stat chemical dilator therapy was performed and she recovered without significant neurological deficits. A real-time and protocol-based cEEG can be utilized in order to avoid any delay in detection of vasospasm in aneurysmal SAH and thereby improve clinical outcomes. ...

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Aphasia and apraxia in dementia: cognitive regression or focal symptoms?

Sat, 12 Mar 2016 04:45:03 +0100

Authors: van den Bergh W Abstract A review is given of the neuropsychological conceptualizations of aphasia and apraxia in SDAT. In the beginning of this century localisationism was prevailing. Later, developmental and cognitive psychology gave an important impetus to reconsider these symptoms in an holistic framework. More recently, since the application of new brain imaging techniques, there is a revival of localizing conceptualizations. PMID: 26956404 [PubMed] (Source: Acta Neuropsychiatrica)



Expressive aphasia as the manifestation of hyperglycemic crisis in type 2 diabetes.

Sat, 12 Mar 2016 00:00:00 +0100

Authors: Lee JH, Kim YA, Moon JH, Min SH, Song YS, Choi SH PMID: 26968185 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)



Interventions in aphasia: an integrative review

Fri, 11 Mar 2016 16:34:11 +0100

RESUMO O objetivo desta revisão foi identificar, avaliar e discutir artigos sobre intervenções e avanços terapêuticos em afasia, publicados periódicos científicos nos últimos cinco anos, em plataformas de livre acesso aos profissionais. Foi realizada uma revisão integrativa nas bases de dados SciELO, LILACS, Periódicos Capes e PubMed, com os descritores em português e inglês: afasia, reabilitação e tratamento. Foram incluídos artigos que descrevessem tratamentos para afasia ou histórias de reabilitação, publicados em inglês ou português. Os estudos que atenderam aos critérios foram lidos e analisados segundo instrumento para revisão integrativa, e posteriormente categorizada. Dos 96 artigos levantados 26 foram incluídos na revisão. Houve predominância de estudos qu...



The aphasia therapeutic process: implications of enunciative-discursive neurolinguistics

Fri, 11 Mar 2016 16:34:11 +0100

RESUMO Na perspectiva da Neurolinguística Enunciativo-Discursiva busca investigar as relações entre a linguagem e o cérebro a partir do contexto sócio-histórica e cultural em que o sujeito se insere. Nesta perspectiva, a terapia fonoaudiológica das afasias propõe situações em que o sujeito afásico pode experienciar a reversibilidade de papéis discursivos inerentes ao uso social da língua. O objetivo deste artigo é apresentar as estratégias utilizadas por um sujeito afásico (estudo de caso), durante o processo terapêutico em uma Clínica de Fonoaudiologia de uma universidade particular do Brasil, ilustrando exemplos de aplicação dos pressupostos da Neurolinguistica Enunciativo-Discursiva. As sessões foram gravadas e analisadas sob a vertente enunciativo-discursiva, com a...



Evaluation of esophageal and airway stent placement for patients with advanced and recurrent esophageal cancer

Thu, 10 Mar 2016 00:00:00 +0100

Conclusions Stent placement is effective for the improvement of malignant dysphasia and dyspnea caused by advanced esophageal cancer. (Source: Esophagus)

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Dementia plaques attack language center of brain

Mon, 07 Mar 2016 20:28:27 +0100

The recent ability to peer into the brain of living individuals with a rare type of language dementia, primary progressive aphasia, provides important insight into the beginning stages of this disease, when it is caused by a buildup of a toxic protein found in Alzheimer's disease. The research also offers insight into why this dementia causes people to lose the ability to express themselves and understand language. The findings will guide Alzheimer's treatment, say researchers. (Source: ScienceDaily Headlines)



Identifying and Addressing Grief and Loss Issues in a Person With Aphasia: A Single‐Case Study

Sun, 06 Mar 2016 00:00:00 +0100

This single‐case study is designed to help counselors conceptualize grief and loss issues experienced by a person with aphasia and improve the effectiveness in counseling individuals with this disability. Given the unique communication needs of this population, creative approaches to counseling are presented. Five themes were identified through the coding of interview transcripts: questioning identity, questioning existence, questioning normality, questioning feelings, and adapting to a new reality. In addition, the overarching theme of disenfranchised grief emerged from the data. (Source: Journal of Counseling and Development)



On the diverse outcome of communication partner training of significant others of people with aphasia: an experimental study of six cases.

Sun, 06 Mar 2016 00:00:00 +0100

CONCLUSIONS & IMPLICATIONS: This study adds to the growing body of research concerning CPT by pinpointing the importance of careful consideration regarding set-up of training, suitability of participants and evaluation of outcome. PMID: 26947265 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)



Wernicke’s aphasia and attempted suicide

Fri, 04 Mar 2016 00:00:00 +0100

(Source: Acta Neurologica Belgica)

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Cognitive and anatomic double dissociation in the representation of concrete and abstract words in semantic variant and behavioral variant frontotemporal degeneration

Thu, 03 Mar 2016 00:00:00 +0100

Publication date: Available online 2 March 2016 Source:Neuropsychologia Author(s): Katheryn AQ Cousins, Collin York, Laura Bauer, Murray Grossman We examine the anatomic basis for abstract and concrete lexical representations in semantic memory by assessing patients with focal neurodegenerative disease. Prior evidence from healthy adult studies suggests that there may be an anatomical dissociation between abstract and concrete representations: abstract words more strongly activate the left inferior frontal gyrus relative to concrete words, while concrete words more strongly activate left anterior-inferior temporal regions. However, this double dissociation has not been directly examined. We test this dissociation in two patient groups with focal cortical atrophy in each of these regi...



The role of the right hemisphere in semantic control: A case-series comparison of right and left hemisphere stroke

Thu, 03 Mar 2016 00:00:00 +0100

Publication date: Available online 2 March 2016 Source:Neuropsychologia Author(s): Hannah E. Thompson, Lauren Henshall, Elizabeth Jefferies Semantic control processes guide conceptual retrieval so that we are able to focus on non-dominant associations and features when these are required for the task or context, yet the neural basis of semantic control is not fully understood. Neuroimaging studies have emphasised the role of left inferior frontal gyrus (IFG) in controlled retrieval, while neuropsychological investigations of semantic control deficits have almost exclusively focussed on patients with left-sided damage (e.g., patients with semantic aphasia, SA). Nevertheless, activation in fMRI during demanding semantic tasks typically extends to right IFG. To investigate the role of th...



Dysarthria as a predictor of dysphagia following stroke.

Tue, 01 Mar 2016 16:37:02 +0100

CONCLUSIONS: A comprehensive evaluation of dysphagia, aphasia, and dysarthria are important to improve clinical outcome following stroke. The identification of dysarthria as a predictor of dysphagia can help identify risk for dysphagia in stroke and assist in the therapeutic process of swallowing problems. PMID: 26923355 [PubMed - as supplied by publisher] (Source: NeuroRehabilitation)



Misconnections in the Critically Ill: Injection of High-Dose Gadolinium into an External Ventricular Drain

Tue, 01 Mar 2016 06:00:00 +0100

We report an unfortunate case of accidental administration of intrathecal gadolinium through an external ventricular drain in a postcraniotomy patient during magnetic resonance imaging of the brain. The incident occurred after the venous contrast line was connected mistakenly to the ventricular drainage catheter. The patient subsequently developed confusion, aphasia, and right facial droop with new computed tomography evidence of diffuse cerebral edema and stroke. Review of the magnetic resonance image revealed the inappropriate presence of subarachnoid gadolinium. Despite all interventions, the patient developed irreversible neurologic disability. We address the clinical sequelae, management strategies, and factors contributing to the catheter misconnection that led to this event. (Source...



Disrupted Intrinsic Local Synchronization in Poststroke Aphasia

Tue, 01 Mar 2016 06:00:00 +0100

We examined the correlations between the abnormal ReHo values and the aphasia severity and language performance in PSA. Compared with HCs, the PSA patients exhibited decreased intrinsic local synchronization in the right lingual gyrus, the left calcarine, the left cuneus, the left superior frontal gyrus (SFG), and the left medial of SFG. The local synchronization (ReHo value) in the left medial of SFG was positively correlated with aphasia severity (r = 0.55, P = 0.027) and the naming scores of Aphasia Battery of Chinese (r = 0.66, P = 0.005). This result is consistent with the important role of this value in language processing even in the resting state. The pathogenesis of PSA may be attributed to abnormal intrinsic local synchronous in multiple brain regions. (Source: ...

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Based on the Network Degeneration Hypothesis: Separating Individual Patients with Different Neurodegenerative Syndromes in a Preliminary Hybrid PET/MR Study

Tue, 01 Mar 2016 00:00:00 +0100

Conclusion: Our finding provides initial evidence that the combination of regional metabolism, functional connectivity, and gray matter volume, which were derived from disease characteristic networks, separates individual patients with different neurodegenerative syndromes. Preliminary results suggest that employing multimodal imaging guided by the NDH may generate promising biomarkers of neurodegenerative syndromes. (Source: Journal of Nuclear Medicine)



Resective surgery for medically refractory epilepsy using intraoperative MRI and functional neuronavigation: the Erlangen experience of 415 patients.

Tue, 01 Mar 2016 00:00:00 +0100

CONCLUSIONS Neuronavigation combined with iMRI was beneficial during surgical procedures for epilepsy and led to favorable seizure outcome with few specific complications. A significantly higher resection volume associated with a higher chance of favorable seizure outcome was found, especially in lesional epilepsy involving LEAT or diffuse glioma. PMID: 26926055 [PubMed - in process] (Source: Neurosurgical Focus)



The "Non-Practicing" Scientist and How She's Here to Help YOU

Mon, 29 Feb 2016 20:30:21 +0100

This article first appeared on Scientista. Visit The Scientista Foundation for more great content! About the Author Heather Burkhart is an energetic science writer and recent graduate from the linguistics program at the University of Utah where she developed an interest in studying aphasia and other language properties of the brain. She is currently Co-Managing Editor for The Scientista Foundation, and editor for its Scientista Spotlight section. When she is not writing in a cozy corner of her home, she is most likely exploring the beautiful outdoor landscape of Utah. Find more of Heather's writing here! -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (S...



The determinants of behavioral symptoms in long-term care facility residents

Sun, 28 Feb 2016 00:00:00 +0100

Publication date: Available online 28 February 2016 Source:European Geriatric Medicine Author(s): U. Pawłucka, P. Brzyski, D. Kubicz, K. Szczerbińska Introduction Evidence exists suggesting that behavioral symptoms are among the most disturbing and distressing behaviors displayed by elderly residents of LTCF. They have been recognized as major concern affecting patient's quality of life and caregiver's satisfaction. However, they have been yet scarcely investigated in Polish LTCF setting. Material and methods The aim of this study was to explore the incidence of behavioral symptoms and to identify their risk factors in a group of 290 residents of one of the biggest LTCF in Poland, using the interRAI-LTCF questionnaire and logistic regression analysis. Results and conclusions In o...



You Left Me Speechless: A Case of Valproic Acid Induced Aphasia

Fri, 26 Feb 2016 01:36:27 +0100

We report here an interesting case of VPA induced aphasia in a post stoke patient. (Source: Journal of the American Medical Directors Association)

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Age and aphasia: a review of presence, type, recovery and clinical outcomes.

Thu, 25 Feb 2016 00:00:00 +0100

CONCLUSIONS: Stroke is a condition of the elderly. However, age appears to only influence likelihood of aphasia and aphasia type. PMID: 26916396 [PubMed - as supplied by publisher] (Source: Topics in Stroke Rehabilitation)



Perfusion and pH MRI in familial hemiplegic migraine with prolonged aura

Wed, 24 Feb 2016 00:00:00 +0100

Discussion During prolonged aura in FHM, MRI shows reduced CBF, capillary flow disturbances and a possible pH drop that could indicate tissue hypoxia. (Source: Cephalalgia)



Paediatric neurological melioidosis: a rehabilitation case report.

Tue, 23 Feb 2016 23:53:02 +0100

Authors: White ME, Hunt J, Connell C, Langdon K Abstract CONTEXT: Melioidosis is a rare condition, endemic to northern Australia and south-east Asia, caused by an infection from the bacteria Burkholderia pseudomallei. The largest epidemiological review to date describes 540 cases of melioidosis seen at Darwin Hospital, in northern Australia, over a 20-year period. Of these, 14 (less than 3%) presented with neurological manifestation, with three deaths. Reports of paediatric cases of melioidosis are rarer. In a review of paediatric cases in northern Australia only eight cases were identified in 10 years. Three of these patients presented with neurological melioidosis, of whom two died in hospital. ISSUES: Whilst the literature refers to prolonged periods of ho...



Creating psychological connections between intervention recipients: development and focus group evaluation of a group singing session for people with aphasia

Tue, 23 Feb 2016 00:00:00 +0100

Conclusions Engagement with health intervention content may be enhanced in group settings when intervention participants begin to establish positive and meaningful psychological connections with other group members. Understanding and actively nurturing these connections should be a core feature of a general framework for the design and delivery of group interventions. (Source: BMJ Open)



Stroke patients' speech loss linked to loss of brain interconnections

Mon, 22 Feb 2016 05:00:00 +0100

(IOS Press) When brain regions that control speech and reading comprehension are destroyed due to blockage of blood flow, patients are often unable to speak or comprehend spoken or written language. These difficulties with language, or 'aphasia,' are a common symptom in the aftermath of stroke. However, in a new study published in Restorative Neurology and Neuroscience, researchers report that damage to the underlying connections among different areas of the brain can also affect the severity of aphasia. (Source: EurekAlert! - Medicine and Health)

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Validating new diagnostic imaging criteria for primary progressive aphasia via anatomical likelihood estimation meta‐analyses

Mon, 22 Feb 2016 00:00:00 +0100

In conclusion, meta‐analyses support the specificity of new diagnostic imaging criteria for PPA and suggest that they should be specified for each imaging modality separately. (Source: European Journal of Neurology)



Global coherence during discourse production in adults: a review of the literature.

Mon, 22 Feb 2016 00:00:00 +0100

CONCLUSIONS & IMPLICATIONS: Although evidence indicated that global coherence is negatively influenced by ageing and neurological disease/injury, the heterogeneity of study populations, measurement tools and study designs were limiting factors in determining the exact nature by which these factors impact the skill of global coherence. PMID: 26899279 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)



Cognitive grammar and aphasic discourse.

Mon, 22 Feb 2016 00:00:00 +0100

Authors: Manning M, Franklin S Abstract In cognitive grammar (CG), there is no clear division between language and other cognitive processes; all linguistic form is conceptually meaningful. In this pilot study, a CG approach was applied to investigate whether people with aphasia (PWA) have cognitive linguistic difficulty not predicted from traditional, componential models of aphasia. Narrative samples from 22 PWA (6 fluent, 16 non-fluent) were compared with samples from 10 participants without aphasia. Between-group differences were tested statistically. PWA had significant difficulty with temporal sequencing, suggesting problems that are not uniquely linguistic. For some, these problems were doubly dissociated with naming, used as a general measure of severity, which indicates tha...



Ultrasonic vocalization in murine experimental stroke: A mechanistic model of aphasia.

Sat, 20 Feb 2016 21:40:02 +0100

CONCLUSION: These findings set a foundation for further studies of mechanisms and novel treatment strategies for post-stroke vocalization impairments. PMID: 26889967 [PubMed - as supplied by publisher] (Source: Restorative Neurology and Neuroscience)



Swallowing in primary progressive aphasia.

Fri, 19 Feb 2016 13:39:01 +0100

CONCLUSIONS: All variants showed swallowing difficulties and they were more frequent in PPA-S. Further studies with larger samples of patients are needed to better characterize swallowing problems and their consequences in the different variants of PPA. PMID: 26889802 [PubMed - as supplied by publisher] (Source: NeuroRehabilitation)

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Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia.

Thu, 18 Feb 2016 11:12:02 +0100

Authors: Griffis JC, Nenert R, Allendorfer JB, Szaflarski JP Abstract The effects of noninvasive neurostimulation on brain structure and function in chronic poststroke aphasia are poorly understood. We investigated the effects of intermittent theta burst stimulation (iTBS) applied to residual language-responsive cortex in chronic patients using functional and anatomical MRI data acquired before and after iTBS. Lateralization index (LI) analyses, along with comparisons of inferior frontal gyrus (IFG) activation and connectivity during covert verb generation, were used to assess changes in cortical language function. Voxel-based morphometry (VBM) was used to assess effects on regional grey matter (GM). LI analyses revealed a leftward shift in IFG activity after treatment. While left ...



Management of developmental speech and language disorders. Part 2: acquired conditions

Thu, 18 Feb 2016 00:00:00 +0100

Many children who present with these acquired impairments of communication have a clear preceding event such as an acquired brain injury from a road traffic accident. Children often respond differently in this situation to adult presentations. They may have a period of mutism when the prognosis might look poor and yet they subsequently make rapid progress and recover speech. They have greater potential for neural plasticity and language recovery, although they often have persisting difficulties in oral and written language. Alternatively, there may be a presentation with a paroxysmal event such as a seizure or a period of depressed consciousness, and the unusual behaviour that may accompany dysphasia and dysarthria may be misinterpreted in the child, whereas for the adult with the more com...



Discourse level reading comprehension interventions following acquired brain injury: a systematic review.

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions Interventions for discourse level reading comprehension can make positive changes to reading function. However, no intervention was identified as a gold standard. A trend toward strategy-based reading was found, with these offering a potential for (comparatively) cost-effective lower-dosage reading treatments with positive-trend results. Cognitive and language features should be considered for assessment and intervention planning for discourse reading in ABI. Implications for Rehabilitation Six different types of discourse reading comprehension interventions for people with ABI were identified, with mixed evidence for each intervention. Clinicians need to consider both the linguistic and cognitive features of reading for assessment and intervention planning for discourse level ...



Cardiovascular Instability Preceded by Orolingual Angioedema after Alteplase Treatment.

Wed, 17 Feb 2016 06:48:02 +0100

Authors: Kageyama T, Okanoue Y, Takai R, Suenaga T Abstract An 87-year-old man taking antihypertensive medications, including 10 mg enalapril, daily visited our hospital complaining of motor aphasia, dysarthria, and right hemiparesis. Magnetic resonance imaging revealed an ischemic lesion in the left frontal lobe including the insular cortex and severe stenosis of the left middle cerebral artery. After he received intravenous alteplase infusion, he developed orolingual angioedema followed by transient bradycardia with subsequent hypotension, resulting in the deterioration of his neurological signs and expansion of the ischemic lesion. Orolingual angioedema after intravenous alteplase infusion may follow cardiovascular instability and disease progression in stroke patients. PMI...



AphasiaBank as BigData

Tue, 16 Feb 2016 00:00:00 +0100

Semin Speech Lang 2016; 37: 010-022DOI: 10.1055/s-0036-1571357AphasiaBank has used a standardized protocol to collect narrative, procedural, personal, and descriptive discourse from 290 persons with aphasia, as well as 190 control participants. These data have been transcribed in the Codes for the Human Analysis of Transcripts (CHAT) format for analysis by the Computerized Language Analysis (CLAN) programs. Here, we review results from 45 studies based on these data that investigate aphasic productions in terms of these eight areas: discourse, grammar, lexicon, gesture, fluency, syndrome classification, social factors, and treatment effects. For each area, we also indicate how use of the CLAN programs has facilitated the analysis. We conclude with an examination of ways in which the size o...

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Verb Production in Aphasia: Testing the Division of Labor between Syntax and Semantics

Tue, 16 Feb 2016 00:00:00 +0100

This study aimed to test Gordon and Dell's “division of labor” hypothesis that light versus heavy verb usage depends on syntactic and semantic processes, respectively. In a retrospective analysis of data from the AphasiaBank corpus, narrative language of neurologically healthy individuals and individuals with aphasia was analyzed for the proportion of light verbs used, and its relationship with narrative measures of syntactic and semantic sophistication and verb naming scores was examined. In individuals with aphasia, light verb usage was positively correlated with a syntactic measure (developmental sentence score) and negatively associated with two semantic measures (idea density and verb naming). For healthy individuals, the number of verbs per utterance, which is a measure of syntac...



Verb Argument Structure in Narrative Speech: Mining AphasiaBank

Tue, 16 Feb 2016 00:00:00 +0100

Semin Speech Lang 2016; 37: 034-047DOI: 10.1055/s-0036-1572383Previous research has found that verb argument structure characteristics (such as the number of participant roles in the situation described by the verb) can facilitate or hinder aphasic language production and comprehension in constrained laboratory tasks. This research needs to be complemented by studies of narrative or unrestricted speech, which can capture the spontaneous selection of verbs and grammatical structures by people with aphasia and may be particularly sensitive to the relative cost of access to different verb types in more natural conditions. Focusing on the number of subcategorization options, we investigated verb argument structure effects in a large sample of narratives from AphasiaBank, by speakers with aphas...



How Does Severity of Aphasia Influence Individual Responsiveness to Rehabilitation? Using Big Data to Understand Theories of Aphasia Rehabilitation

Tue, 16 Feb 2016 00:00:00 +0100

This article examines the utility of big data analysis for understanding one of these factors, severity of impairment, and how individual responsiveness to rehabilitation is influenced by a patient's severity of language and cognitive impairment(s). Using examples from two studies and a larger data set, we show that when rehabilitation is tailored to an individual's specific level of impairment, severe and mild patients both show improvements in accuracy and latency. Furthermore, more severe patients tend to show substantial gains on targeted rehabilitation tasks as well as on standardized tests. These results provide support for recent reviews of aphasia rehabilitation studies in concluding that systematic aphasia rehabilitation is indeed effective, and importantly, severity is not a nega...



The effects of behavioral and psychological symptoms on caregiver burden in frontotemporal dementia, Lewy body dementia, and Alzheimer's disease: clinical experience in China.

Tue, 16 Feb 2016 00:00:00 +0100

CONCLUSION: BPSD was highly correlated with emotional burden in caregivers of FTD, DLB, and AD patients. The highest burden was observed in bvFTD caregivers. PMID: 26882509 [PubMed - as supplied by publisher] (Source: Aging and Mental Health)



Brain disorder often mistaken for Alzheimer's leaves sufferers 'verbally locked in'

Mon, 15 Feb 2016 18:59:59 +0100

Primary progressive aphasia robs sufferers of the ability to recall words, and is often mistaken for dementia where people cannot recall memories, experts at Johns Hopkins University in Baltimore said. (Source: the Mail online | Health)

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A Candid Conversation With Kim Campbell On The Rhinestone Cowboy, Alzheimer's And Living Life As A Caregiver

Mon, 15 Feb 2016 12:42:15 +0100

"I have a black eye, but I'm hanging in there." Kim Campbell, tells me. "Caregiving is hard," she says. "I don't know how people do it." Kim's husband, legendary country singer, Glen Campbell, rocked awareness when he and his family let the world know their secret. Together they toured the country after bravely announcing he had Alzheimer's diseaselen playing his heart out with his musically talented children: son, Shannon and daughter, Ashley, by his side. Napa Valley was their final stage, Glen's last encore. By that night, his struggle through the plaques and tangles plaguing his brain had become too difficult. Kim was by her husband's side through the journey, as she continues to be for Glen today. I first met Kim and Ashley Campbell in Naples, Florida at the grand opening of a state...



Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions

Mon, 15 Feb 2016 00:00:00 +0100

Conclusions: Distribution of TDP-43 inclusions and neurons, and to a smaller extent of activated microglia, show a regional and hemispheric pattern consistent with disease phenotype and known patterns of atrophy in PPA with GRN mutations. (Source: Neurology)



Discovering EEG resting state alterations of Semantic Dementia

Mon, 15 Feb 2016 00:00:00 +0100

Semantic dementia (SD) is a variant of the Frontotemporal Lobar Degeneration (FTLD), a spectrum of non-Alzheimer’s dementias (Neary et al., 1998). It is characterized by a progressive language disorder with fluent, empty spontaneous speech, and loss of word meaning, commonly manifested by impaired naming and semantic paraphrases. Following this, SD has also been referred to as the semantic variant of primary progressive aphasia (Gorno-Tempini et al., 2011). According to the diagnostic guidelines of this clinical syndrome, it also encompasses a variety of symptoms such as loss of sympathy and empathy, and narrowed preoccupations (Snowden et al., 2001; Rankin et al., 2005). (Source: Clinical Neurophysiology)



Temporal stability and responsiveness of the Montreal Cognitive Assessment following acquired brain injury.

Sun, 14 Feb 2016 18:19:03 +0100

CONCLUSIONS: The MoCA is a brief standardized tool that appears useful for monitoring cognitive change after ABI. The findings enable clinicians to detect statistically reliable change across serial MoCA administrations in individuals with an ABI. PMID: 26556208 [PubMed - in process] (Source: Brain Injury)



Multimodal Communication Training in Aphasia: A Pilot Study.

Sat, 13 Feb 2016 14:04:02 +0100

Authors: Purdy M, Van Dyke JA Abstract Management of patients with aph asia often focuses on training nonverbal augmentative communication strategies; however, these strategies frequently do not generalize to natural situations. The limited success may be because training waS not sufficient to produce an integrated multimodal semantic representation. The purpose of this study was to examine whether simultaneous training of stimuli in both verbal and nonverbal modalities would solidify the links within the semantic network and improve switching among modalities as needed in conversation. Two individuals with severe aphasia participated in 6 to 8 hours of Multi moda I Communication Training (MeT), during which they conveyed a concept by verbalizing, gesturing, writing, and drawing. A...

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Success of Anomia Treatment in Aphasia Is Associated With Preserved Architecture of Global and Left Temporal Lobe Structural Networks

Fri, 12 Feb 2016 00:00:00 +0100

Conclusions. Preservation of global and left temporal structural connectivity broadly explains the variability in treatment-related naming improvement in aphasia. These findings corroborate and expand on previous classical lesion-symptom mapping studies by elucidating some of the mechanisms by which brain damage may relate to treated aphasia recovery. Favorable naming outcomes may result from the intact connections between spared cortical areas that are functionally responsive to treatment. (Source: Neurorehabilitation and Neural Repair)



Subacute progressive aphasia: a rare presentation of Creutzfeldt–Jakob disease

Fri, 12 Feb 2016 00:00:00 +0100

(Source: Journal of Neurology)



ID 448 – Brain-guided therapy in post-stroke aphasia

Thu, 11 Feb 2016 06:19:56 +0100

Find a novel approach for therapy of post-stroke aphasia utilizing personal-emotional words identified in a pre-therapy brain function assessment. (Source: Clinical Neurophysiology)



Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis.

Wed, 10 Feb 2016 16:53:01 +0100

CONCLUSIONS: Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions. PMID: 26854827 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)



Validation of the Stroke and Aphasia Quality of Life Scale in a multicultural population.

Wed, 10 Feb 2016 00:00:00 +0100

Conclusions Both the SAQOL-39 g and SAQOL-CSg demonstrated good reliability and validity. Our results suggested some influence of ethnicity in self-rating of health status in relation to SAQOL-39 g scores. Further research is warranted to examine its use with stroke survivors with greater stroke severity and over time. Implications for Rehabilitation Validation of SAQOL in Singapore: Both the SAQOL-39g and the SAQOL-CSg may be used to measure the HRQoL of stroke survivors with and without aphasia in Singapore. Further investigation is required to examine use with stroke survivors with greater stroke severity and over time. PMID: 26860472 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)

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Survival in Frontotemporal Dementia Phenotypes: A Meta-Analysis

Mon, 08 Feb 2016 14:04:35 +0100

Conclusions: Survival differs for FTD phenotypes but, except for FTD-ALS, compares well to AD survival. Elucidating the potential causes of within-phenotype heterogeneity in survival (such as complicating features and comorbidities) may open up opportunities for tailored interventions.Dement Geriatr Cogn Disord 2016;41:109-122 (Source: Dementia and Geriatric Cognitive Disorders)



Does Naming Accuracy Improve Through Self-Monitoring of Errors?

Mon, 08 Feb 2016 00:00:00 +0100

This study examined spontaneous self-monitoring of picture naming in people with aphasia. Of primary interest was whether spontaneous detection or repair of an error constitutes an error signal or other feedback that tunes the production system to the desired outcome. In other words, do acts of monitoring cause adaptive change in the language system? A second possibility, not incompatible with the first, is that monitoring is indicative of an item’s representational strength, and strength is a causal factor in language change. Twelve PWA performed a 615-item naming test twice, in separate sessions, without extrinsic feedback. At each timepoint, we scored the first complete response for accuracy and error type and the remainder of the trial for verbalizations consistent with detection (e....



Stereotactic radiosurgery for the treatment of mesial temporal lobe epilepsy

Fri, 05 Feb 2016 14:19:32 +0100

ConclusionOur findings indicate that RS may have similar or slightly less efficacy in some patients compared with invasive surgery. Randomized controlled trials of both treatment regimens should be undertaken to generate an evidence base for patient decision‐making. (Source: Acta Neurologica Scandinavica)



Structural prediction in aphasia: Evidence from either

Fri, 05 Feb 2016 00:00:00 +0100

Publication date: August 2016 Source:Journal of Neurolinguistics, Volume 39 Author(s): Tessa Warren, Michael Walsh Dickey, Chia-Ming Lei Young neurotypical adults engage in prediction during language comprehension (e.g., Altmann & Kamide, 1999; Staub & Clifton, 2006; Yoshida, Dickey & Sturt, 2013). The role of prediction in aphasic comprehension is less clear. Some evidence suggests that lexical prediction may be spared in aphasia (Dickey, Warren, Hayes, & Milburn, 2014; Love & Webb, 1977; cf. Mack, Ji, & Thompson, 2013), and there is even indication that structural prediction may be spared in some people with aphasia (PWA; e.g. Hanne, Burchert, De Bleser, & Vashishth, 2015). The current self-paced reading experiment manipulated ...



Taking Sides: An Integrative Review of the Impact of Laterality and Polarity on Efficacy of Therapeutic Transcranial Direct Current Stimulation for Anomia in Chronic Poststroke Aphasia.

Mon, 01 Feb 2016 00:42:05 +0100

Authors: Sandars M, Cloutman L, Woollams AM Abstract Anomia is a frequent and persistent symptom of poststroke aphasia, resulting from damage to areas of the brain involved in language production. Cortical neuroplasticity plays a significant role in language recovery following stroke and can be facilitated by behavioral speech and language therapy. Recent research suggests that complementing therapy with neurostimulation techniques may enhance functional gains, even amongst those with chronic aphasia. The current review focuses on the use of transcranial Direct Current Stimulation (tDCS) as an adjunct to naming therapy for individuals with chronic poststroke aphasia. Our survey of the literature indicates that combining therapy with anodal (excitatory) stimulation to the left hemis...

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Distinctive pathological mechanisms involved in primary progressive aphasias.

Mon, 01 Feb 2016 00:00:00 +0100

Authors: Leyton CE, Britton AK, Hodges JR, Halliday GM, Kril JJ Abstract Primary progressive aphasia (PPA) comprises a heterogeneous group of neurodegenerative conditions that can be classified in three cliniconeuroanatomic syndromes. Limited information exists, however, about patterns of neuropathologic spreading and microscopic changes underpinning each syndrome. We performed an analysis of a longitudinal in vivo cohort and a postmortem PPA cohort to investigate neurodegeneration over time and to quantify microscopic changes in key language brain areas. The longitudinal analyses demonstrated distinctive patterns of topological extension of brain atrophy. Although semantic variant (sv-PPA) showed an eccentric pattern, nonfluent and/or agrammatic (nfv-PPA) and logopenic (lv-PPA) v...



Tau, amyloid, and hypometabolism in the logopenic variant of primary progressive aphasia

Mon, 01 Feb 2016 00:00:00 +0100

A 57-year-old right-handed woman had an 8-year history of progressive word retrieval and repetition deficits, consistent with the logopenic variant of Alzheimer disease.1 She was studied using the novel hyperphosphorylated-tau tracer 18F-AV-1451,2 in conjunction with metabolic (18F-fluorodeoxyglucose [FDG]) and β-amyloid (18F-florbetapir) PET (figure). Areas with high tau, such as the left inferior parietal lobule, had decreased metabolism. By contrast, some areas with high amyloid, such as striated cortex, had normal metabolism. This case illustrates tau sparing of primary cortex and provides preliminary in vivo evidence that regional tau is more closely linked to hypometabolism than amyloid density. (Source: Neurology)



How Does Severity of Aphasia Influence Individual Responsiveness to Rehabilitation? Using Big Data to Understand Theories of Aphasia Rehabilitation.

Mon, 01 Feb 2016 00:00:00 +0100

This article examines the utility of big data analysis for understanding one of these factors, severity of impairment, and how individual responsiveness to rehabilitation is influenced by a patient's severity of language and cognitive impairment(s). Using examples from two studies and a larger data set, we show that when rehabilitation is tailored to an individual's specific level of impairment, severe and mild patients both show improvements in accuracy and latency. Furthermore, more severe patients tend to show substantial gains on targeted rehabilitation tasks as well as on standardized tests. These results provide support for recent reviews of aphasia rehabilitation studies in concluding that systematic aphasia rehabilitation is indeed effective, and importantly, severity is not a nega...



Verb Argument Structure in Narrative Speech: Mining AphasiaBank.

Mon, 01 Feb 2016 00:00:00 +0100

Authors: Malyutina S, Richardson JD, den Ouden DB Abstract Previous research has found that verb argument structure characteristics (such as the number of participant roles in the situation described by the verb) can facilitate or hinder aphasic language production and comprehension in constrained laboratory tasks. This research needs to be complemented by studies of narrative or unrestricted speech, which can capture the spontaneous selection of verbs and grammatical structures by people with aphasia and may be particularly sensitive to the relative cost of access to different verb types in more natural conditions. Focusing on the number of subcategorization options, we investigated verb argument structure effects in a large sample of narratives from AphasiaBank, by speakers with ...



Verb Production in Aphasia: Testing the Division of Labor between Syntax and Semantics.

Mon, 01 Feb 2016 00:00:00 +0100

This study aimed to test Gordon and Dell's "division of labor" hypothesis that light versus heavy verb usage depends on syntactic and semantic processes, respectively. In a retrospective analysis of data from the AphasiaBank corpus, narrative language of neurologically healthy individuals and individuals with aphasia was analyzed for the proportion of light verbs used, and its relationship with narrative measures of syntactic and semantic sophistication and verb naming scores was examined. In individuals with aphasia, light verb usage was positively correlated with a syntactic measure (developmental sentence score) and negatively associated with two semantic measures (idea density and verb naming). For healthy individuals, the number of verbs per utterance, which is a measure of syntactic ...

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AphasiaBank as BigData.

Mon, 01 Feb 2016 00:00:00 +0100

Authors: MacWhinney B, Fromm D Abstract AphasiaBank has used a standardized protocol to collect narrative, procedural, personal, and descriptive discourse from 290 persons with aphasia, as well as 190 control participants. These data have been transcribed in the Codes for the Human Analysis of Transcripts (CHAT) format for analysis by the Computerized Language Analysis (CLAN) programs. Here, we review results from 45 studies based on these data that investigate aphasic productions in terms of these eight areas: discourse, grammar, lexicon, gesture, fluency, syndrome classification, social factors, and treatment effects. For each area, we also indicate how use of the CLAN programs has facilitated the analysis. We conclude with an examination of ways in which the size of the database...



Outcomes of Short-Course Inpatient Stroke Rehabilitation Program in Tertiary Hospital: A Pilot Study.

Sat, 30 Jan 2016 10:15:04 +0100

CONCLUSION: The short-course inpatient rehabilitation program could improve functional ability in stroke patients with low cost but high efficiency. This program is suitable for subacute stroke patients in hospitals with limited resources and budget. PMID: 26817186 [PubMed - in process] (Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet)



Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia

Fri, 29 Jan 2016 00:00:00 +0100

We presented 28 patients with behavioural variant frontotemporal dementia, 14 patients with semantic variant primary progressive aphasia, 25 patients with Alzheimer’s disease (as disease controls), and 61 healthy older control subjects with experimental tasks assaying loss aversion and delay discounting. In general linear models controlling for age, gender, education and Mini-Mental State Examination score, patients with behavioural variant frontotemporal dementia were less averse to losses than control subjects (P < 0.001), while patients with semantic variant primary progressive aphasia discounted delayed rewards more steeply than controls (P = 0.019). There was no relationship between loss aversion and delay discounting across the sample, nor in any of the subgroups. These find...



Epidural Cortical Stimulation as a Treatment for Poststroke Aphasia: A Systematic Review of the Literature and Underlying Neurophysiological Mechanisms

Wed, 27 Jan 2016 00:00:00 +0100

Conclusions. Due to the small number of existing cases in the literature, the strength of the evidence is still low. Two main hypotheses of neurobiological mechanisms have been explored: either using continuous stimulation to modify cortical perilesional inhibition or using intermittent stimulation during the speech and language therapy sessions to explore synaptic plasticity and long-term potentiation or depression. To establish the role of epidural stimulation and the relevant stimulation protocols and parameters, large randomized controlled trials are mandatory. We suggest avenues of investigation. (Source: Neurorehabilitation and Neural Repair)



Epidural Cortical Stimulation as Adjunctive Treatment for Nonfluent Aphasia: Phase 1 Clinical Trial Follow-up Findings

Wed, 27 Jan 2016 00:00:00 +0100

Conclusions. Improvements were generally maintained for at least 12 weeks posttreatment and possibly as long as 21 months posttreatment. Epidural CS is a potentially safe, feasible adjunctive intervention for persons with chronic nonfluent aphasia that spares the ventral premotor cortex and warrants further investigation. (Source: Neurorehabilitation and Neural Repair)

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Supporting communication for patients with neurodegenerative disease.

Mon, 25 Jan 2016 21:02:02 +0100

CONCLUSIONS: AAC should be standard practice for adults with neurodegenerative disease. Patients can maintain effective, functional communication with AAC supports. Individualized communication systems can be implemented ensuring patients remain active participants in daily activities. PMID: 26409694 [PubMed - in process] (Source: NeuroRehabilitation)



Feasibility of using high-definition transcranial direct current stimulation (HD-tDCS) to enhance treatment outcomes in persons with aphasia.

Mon, 25 Jan 2016 21:02:02 +0100

CONCLUSIONS: Regarding feasibility, HD-tDCS treatment studies can be implemented when designed similarly to documented CS-tDCS studies. HD-tDCS is likely to be acceptable to patients and clinicians. Preliminary efficacy data suggest that HD-tDCS effects, using only 4 electrodes, are at least comparable to CS-tDCS. PMID: 25547776 [PubMed - indexed for MEDLINE] (Source: NeuroRehabilitation)



Therapeutic effect of repetitive magnetic stimulation combined with speech and language therapy in post-stroke non-fluent aphasia.

Mon, 25 Jan 2016 21:02:02 +0100

CONCLUSIONS: rTMS combined with SLT can be an effective therapeutic method for treating aphasia in post-stroke non-fluent aphasic patients, although additional controlled and more systemic studies should be conducted. PMID: 25547773 [PubMed - indexed for MEDLINE] (Source: NeuroRehabilitation)



Validation of the Lille's Apathy Rating Scale in Very Mild to Moderate Dementia.

Mon, 25 Jan 2016 19:22:02 +0100

CONCLUSION: LARS is reliable and valid for detecting and quantifying apathy in patients with dementia, even in very early stages of the disease. PMID: 26803583 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Psychiatry)



Preservation of structural brain network hubs is associated with less severe post-stroke aphasia.

Mon, 25 Jan 2016 16:44:02 +0100

CONCLUSIONS: Disruption of language network structural hubs is directly associated with aphasia severity after stroke. PMID: 26599472 [PubMed - in process] (Source: Restorative Neurology and Neuroscience)

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L-dopa does not add to the success of high-intensity language training in aphasia.

Mon, 25 Jan 2016 16:44:02 +0100

CONCLUSION: High-intensity language training in chronic aphasia may take learning to a ceiling that precludes additive benefits from l-dopa. Effects of l-dopa on post-stroke recovery during less intense treatment in chronic aphasia remain to be evaluated. PMID: 25588456 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)



Do all sub acute stroke patients benefit from robot-assisted therapy? A retrospective study.

Mon, 25 Jan 2016 16:44:02 +0100

CONCLUSION: High intensity robot-assisted training may be associated with motor improvement in subacute hemiparesis. More severely impaired patients may derive greater benefit from robot-assisted training; age, aphasia and neglect do not represent exclusion criteria. PMID: 25420902 [PubMed - indexed for MEDLINE] (Source: Restorative Neurology and Neuroscience)



Quality of Life in Aphasia: State of the Art

Sat, 23 Jan 2016 02:04:05 +0100

Folia Phoniatr Logop 2015;67:114-118 (Source: Folia Phoniatrica et Logopaedica)



An International Perspective on Quality of Life in Aphasia: A Survey of Clinician Views and Practices from Sixteen Countries

Sat, 23 Jan 2016 02:04:05 +0100

Conclusion: There is a need for training on quality of life to help speech and language therapists incorporate quality of life outcome measures in their interventions. There is also a need for further research on which interventions improve quality of life in aphasia.Folia Phoniatr Logop 2015;67:119-130 (Source: Folia Phoniatrica et Logopaedica)



Practitioners' Perspectives on Quality of Life in Aphasia Rehabilitation in Denmark

Sat, 23 Jan 2016 02:04:05 +0100

Conclusion: Despite a reported lack of knowledge about and tools for measuring QoL, Danish clinicians are applying QoL issues in their practice and perceive these issues as valuable and important in assessment and therapy. The findings have clear implications for tool development and workforce education.Folia Phoniatr Logop 2015;67:131-144 (Source: Folia Phoniatrica et Logopaedica)

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‘Living with Aphasia the Best Way I Can': A Feasibility Study Exploring Solution-Focused Brief Therapy for People with Aphasia

Sat, 23 Jan 2016 02:04:05 +0100

Conclusions: This small-scale study suggests that solution-focused brief therapy is a promising approach to helping people with aphasia build positive change in their lives.Folia Phoniatr Logop 2015;67:156-167 (Source: Folia Phoniatrica et Logopaedica)



Difficulty in identification of the frontal language area in patients with dominant frontal gliomas that involve the pars triangularis.

Fri, 22 Jan 2016 00:00:00 +0100

Conclusions Identification of the FLA can be difficult in patients with frontal gliomas on the dominant side that involve the PT, but the positive mapping rate of the FLA was 95% in patients without involvement of the PT. These findings are useful for establishing a positive mapping strategy for patients undergoing awake craniotomy for the treatment of frontal gliomas on the dominant side. Thoroughly positive language mapping with subcortical electrical stimulation should be performed in patients without involvement of the PT. More careful continuous neurological monitoring combined with subcortical electrical stimulation is needed when removing dominant-side frontal gliomas that involve the PT. PMID: 26799301 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)



A case of expressive-vocal amusia in a right-handed patient with left hemispheric cerebral infarction.

Fri, 22 Jan 2016 00:00:00 +0100

Authors: Uetsuki S, Kinoshita H, Takahashi R, Obata S, Kakigi T, Wada Y, Yokoyama K Abstract A 53-year-old right-handed woman had an extensive lesion in the left hemisphere due to an infarction caused by vasospasm secondary to subarachnoid bleeding. She exhibited persistent expressive-vocal amusia with no symptoms of aphasia. Evaluation of the patient's musical competence using the Montreal Battery for Evaluation of Amusia, rhythm reproduction tests, acoustic analysis of pitch upon singing familiar music, Japanese standard language tests, and other detailed clinical examinations revealed that her amusia was more dominantly related to pitch production. The intactness of her speech provided strong evidence that the right hemisphere played a major role in her linguistic processing. Da...



Aphasia and unilateral spatial neglect due to acute thalamic hemorrhage: clinical correlations and outcomes

Thu, 21 Jan 2016 00:00:00 +0100

In this study, we investigated the relationship between aphasia/neglect and hematoma volume, hematoma type, and the ADL. One hundred fifteen patients with thalamic hemorrhage (70 men and 45 women) were studied. Their mean age was 68.9 ± 10.3 years, and patients with both left and right lesions were included. We calculated hematoma volume and examined the presence or absence of aphasia/neglect and the relationships between these dysfunctions and hematoma volume, hematoma type, and the ADL. Fifty-nine patients were found to have aphasia and 35 were found to have neglect. Although there was no relationship between hematoma type and cognitive dysfunction, hematoma volume showed a correlation with the severity of cognitive dysfunction. The ADL score and ratio of patient discharge for patien...



Effect of meaning on apraxic finger imitation deficits

Thu, 21 Jan 2016 00:00:00 +0100

Publication date: February 2016 Source:Neuropsychologia, Volume 82 Author(s): E.I.S. Achilles, G.R. Fink, M.H. Fischer, A. Dovern, A. Held, D.C. Timpert, C. Schroeter, K. Schuetz, C. Kloetzsch, P.H. Weiss Apraxia typically results from left-hemispheric (LH), but also from right-hemispheric (RH) stroke, and often impairs gesture imitation. Especially in LH stroke, it is important to differentiate apraxia-induced gesture imitation deficits from those due to co-morbid aphasia and associated semantic deficits, possibly influencing the imitation of meaningful (MF) gestures. To explore this issue, we first investigated if the 10 supposedly meaningless (ML) gestures of a widely used finger imitation test really carry no meaning, or if the test also contains MF gestures, by asking heal...

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Minimally-invasive trans-sulcal resection of Intra-ventricular and Peri-ventricular lesions through a tubular retractor system: Multi-centric experience and results

Thu, 21 Jan 2016 00:00:00 +0100

Conventional approaches to deep-seated cerebral lesions range from biopsy to trans-cortical or trans-callosal resection. While the former doesn’t reduce tumor burden, the latter are more invasive and associated with greater potential for irreparable injury to normal brain. Disconnection syndrome, hemiparesis, hemi-anesthesia or aphasia is not uncommon after such surgery, especially when lesion is large. By contrast, the trans-sulcal parafascicular approach utilizes naturally existing corridors and employs a tubular retractor to minimize brain injury. (Source: World Neurosurgery)



Minimally Invasive Transsulcal Resection of Intraventricular and Periventricular Lesions Through a Tubular Retractor System: Multicentric Experience and Results

Thu, 21 Jan 2016 00:00:00 +0100

Conventional approaches to deep-seated cerebral lesions range from biopsy to transcortical or transcallosal resection. Although the former does not reduce tumor burden, the latter are more invasive and associated with greater potential for irreparable injury to normal brain. Disconnection syndrome, hemiparesis, hemianesthesia, or aphasia is not uncommon after such surgery, especially when lesion is large. By contrast, the transsulcal parafascicular approach uses naturally existing corridors and a tubular retractor to minimize brain injury. (Source: World Neurosurgery)



Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech

Wed, 20 Jan 2016 00:00:00 +0100

Publication date: Available online 20 January 2016 Source:NeuroImage: Clinical Author(s): Jennifer L. Whitwell, Stephen D. Weigand, Joseph R. Duffy, Edythe A. Strand, Mary M. Machulda, Matthew L. Senjem, Jeffrey L. Gunter, Val J. Lowe, Clifford R. Jack, Keith A. Josephs Beta-amyloid (Aβ) deposition can be observed in primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS). While it is typically associated with logopenic PPA, there are exceptions that make predicting Aβ status challenging based on clinical diagnosis alone. We aimed to determine whether MRI regional volumes or clinical data could help predict Aβ deposition. One hundred and thirty-nine PPA (n=97; 15 agrammatic, 53 logopenic, 13 semantic and 16 unclassified) and PAOS (n=42) subjects were prosp...



Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

Wed, 20 Jan 2016 00:00:00 +0100

Conclusions and Relevance This study demonstrated the use of speech measures in the identification of those with an oral-motor deficit, and showed the usefulness of performing a relatively simple reading test to assess speech versus pause behaviors across the ALS—FTD disease continuum. The findings also suggest that motor speech assessment should be performed as part of the diagnostic workup for patients with FTD. (Source: PLoS One)



Emergent surgical embolectomy in conjunction with cervical internal carotid ligation and superficial temporal artery-middle cerebral artery bypass to treat acute tandem internal carotid and middle cerebral artery occlusion due to cervical internal carotid artery dissection.

Sat, 16 Jan 2016 23:36:02 +0100

CONCLUSIONS: Surgical embolectomy in conjunction with ligation of the cervical ICA followed by STA-MCA bypass might be a safe alternative method to endovascular recanalization, when the cervical dissection is extensive and when huge secondary emboli are present along the MCA. PMID: 26759736 [PubMed] (Source: Surgical Neurology International)

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When a Little Knowledge Can Be Dangerous: False-Positive Diagnosis of Behavioral Variant Frontotemporal Dementia among Community Clinicians.

Sat, 16 Jan 2016 19:20:02 +0100

CONCLUSION: These results revealed a widespread lack of familiarity with core diagnostic symptoms among non-specialists and suggest that community clinicians require specialized diagnostic support before providing a definitive diagnosis of bvFTD. PMID: 26741499 [PubMed - as supplied by publisher] (Source: Dementia and Geriatric Cognitive Disorders)



Headache, dysphasia and a left temporal lobe mass: question

Sat, 16 Jan 2016 00:00:00 +0100

Publication date: February 2016 Source:Journal of Clinical Neuroscience, Volume 24 Author(s): Kiryu K. Yap, David Oehme, Tiew F. Han (Source: Journal of Clinical Neuroscience)



Headache, dysphasia and a left temporal lobe mass: answer

Sat, 16 Jan 2016 00:00:00 +0100

Publication date: February 2016 Source:Journal of Clinical Neuroscience, Volume 24 Author(s): Kiryu K. Yap, David Oehme, Tiew F. Han (Source: Journal of Clinical Neuroscience)



Carotid artery dissection following adenoidectomy

Sat, 16 Jan 2016 00:00:00 +0100

We describe the case of seven year old girl, who suffered from left internal carotid artery dissection following adenoidectomy, leading to right hemiplegia with global aphasia. A CT angiogram confirmed a loop in contralateral right internal carotid artery. It is presumed that a similar loop also existed in left internal carotid artery, which possibly extended medially close to posterior pharyngeal wall and was injured during the course of surgery. (Source: International Journal of Pediatric Otorhinolaryngology)



Successful treatment of cerebral emboli with tissue plasminogen activator in a patient with takotsubo cardiomyopathy: A case report

Wed, 13 Jan 2016 00:00:00 +0100

Publication date: Available online 12 January 2016 Source:Journal of Cardiology Cases Author(s): Shuntaro Ikeda, Chika Murakami, Shigehiro Miyazaki, Tatsuro Hitsumoto, Hisaki Kadota, Hideaki Shimizu, Kiyotaka Ohshima, Mareomi Hamada Takotsubo cardiomyopathy is a cardiac syndrome characterized by reversible left ventricular wall motion abnormalities. It mimics the acute coronary syndrome; however, significant obstructive coronary artery disease is absent. The prognosis is relatively favorable in many cases, but complications may occur during the acute stage. Herein, we present a case of takotsubo cardiomyopathy in a 76-year-old woman. Three days after admission for persistent chest pains, the patient suddenly developed right hemiplegia, right homonymous hemianopsia, and aphasia. B...

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The Relationships between the amount of spared tissue, percent signal change, and accuracy in semantic processing in aphasia

Wed, 13 Jan 2016 00:00:00 +0100

This study included 14 persons with aphasia in the chronic stage of recovery (six or more months post stroke), along with normal controls, who performed semantic processing tasks of determining whether a written semantic feature matched a picture or whether two written words were related or not. Using region of interest (ROI) analysis, we found that left inferior frontal gyrus pars opercularis and pars triangularis, despite significant damage, were the only regions to correlate with behavioral accuracy. Additionally, bilateral frontal regions including superior frontal gyrus, middle frontal gyrus, and anterior cingulate appear to serve as an assistive network in the case of damage to traditional language regions that include inferior frontal gyrus, middle temporal gyrus, supramarginal gyru...



Thrombolysis in Stroke Patients with Isolated Aphasia

Tue, 12 Jan 2016 21:31:20 +0100

Background: Data about evolution of aphasia following stroke are rare and controversial especially following fibrinolysis. The aim of this study was to describe the early clinical patterns of isolated aphasia in consecutive stroke patients with or without thrombolysis. Methods: Clinical and radiological data of consecutive stroke patients were routinely entered in prospective registry. Patients were considered aphasic when NIHSS (National Institutes of Health Stroke Scale) item 9 >0. ‘Isolated aphasia' was defined by aphasic patients without motor limb deficit. We created a ‘composite language score' obtained by summing the NIHSS items 1b, 1c and 9, which reflects language-processing ability. Recovery of functions was evaluated as measured by global NIHSS, composite language score and ...



When a Little Knowledge Can Be Dangerous: False-Positive Diagnosis of Behavioral Variant Frontotemporal Dementia among Community Clinicians

Tue, 12 Jan 2016 19:45:32 +0100

Conclusion: These results revealed a widespread lack of familiarity with core diagnostic symptoms among non-specialists and suggest that community clinicians require specialized diagnostic support before providing a definitive diagnosis of bvFTD.Dement Geriatr Cogn Disord 2016;41:99-108 (Source: Dementia and Geriatric Cognitive Disorders)



Heterogeneity of patients receiving artificial nutrition in Japanese psychiatric hospitals: a cross‐sectional study

Tue, 12 Jan 2016 00:00:00 +0100

ConclusionAbout one‐fifth of the subjects receiving artificial nutrition were in a vegetative state. More than a few patients with mental disorders, including schizophrenia, also received long‐term artificial nutrition. We should pay more attention to chronic dysphasia syndrome in mental disorders. (Source: Psychogeriatrics)



Logopenic variant of primary progressive aphasia – Case report

Tue, 12 Jan 2016 00:00:00 +0100

Conclusions Diagnosis of primary progressive aphasia requires a close cooperation between neurologist, speech therapists and psychologists. Clinical presentation, due to various level of cognitive decline at first stages of the disease and individualization of the clinical picture, is nonuniform. Recently created diagnostic criteria make both basic diagnosis and diagnosis of the primary progressive aphasia variants easier. This may lead choosing the rehabilitation methods easier in case of disordered language functions and other cognitive domains. (Source: Polish Annals of Medicine)

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