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MedWorm: Amnesia provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Amnesia category.

Last Build Date: Tue, 22 Mar 2016 08:29:30 +0100


Does Prevagen® Help Memory Loss? Does Prevagen® Help Memory Loss?

Fri, 18 Mar 2016 19:51:28 +0100

Can a dietary supplement whose main ingredient was originally discovered in jellyfish improve memory problems? Medscape Pharmacists (Source: Medscape Today Headlines)

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People who exercise more also tend to drink more (alcohol)

Fri, 18 Mar 2016 13:00:52 +0100

In this study, volunteers used a smartphone to record their daily drinking and exercise habits in 3-week blocks. This smartphone technique made it possible to get good information and to analyze daily variations for each individual. What is clear from the analysis is that people tend to drink more alcohol on days when they exercise more. This is true whether they’re young, old, male, or female. This is not a study of problem drinkers or risky drinkers, nor of people with alcohol use disorders (what we used to call alcohol abuse or alcohol dependence). This is also not a study of the effect of an intervention to change lifestyle behavior. That is to say, this study does not tell me what happens if I advise a patient to exercise more or to drink less. The study also does not suggest that i...

Michigan Lead Poisoning Crisis: Is Your Water Safe?

Thu, 17 Mar 2016 20:57:46 +0100

I’ve been watching the crisis in Flint, Michigan, with increasing alarm. The city’s old pipes and fixtures are still leaching lead, poisoning water users and creating a state of emergency. More than 100,000 people are still without safe tap water.  In some cases, the water was found to contain such high levels of lead it’s been classified as “toxic waste.” What is lead poisoning? As you may know, lead is one of the most toxic heavy metals out there. People in Flint can’t drink, cook bathe or brush their teeth with the city’s water without the risk of being poisoned. And while you may have been told Flint is an extreme case, it’s hardly the only one. Lead levels in water have been deemed “unsafe” in other parts of Michig...

Memories 'taken' by Alzheimer's could possibly be retrieved

Thu, 17 Mar 2016 15:30:00 +0100

Conclusion This is a small but intriguing study, not least because of the apparent ability of scientists to pinpoint and label the exact nerve cells involved in the formation of specific memories. The researchers found their technique of brain stimulation using blue light seemed to have dramatic effects on the memory of mice. This suggests the AD mice were able to form memories – and, with the right stimulus, they could also retrieve them. This insight helps researchers build a better understanding of how Alzheimer's disease works and how it affects memory. However, this work may not translate into treatments for people with Alzheimer's disease. As the researchers point out, we already know of some significant differences in the way memory loss and brain degeneration affect mice and ...

MIT scientists find evidence that Alzheimer’s ‘lost memories’ may one day be recoverable

Thu, 17 Mar 2016 15:25:26 +0100

Memory loss is one of the hallmarks of Alzheimer's and heartbreaking for loved ones to watch progress. Gone are the details of a first love or a child's wobbly first steps. The achievements of a distinguished 30-year career. And the tall tales of traveling the globe that once had everyone rolling on the floor with laughter. Scientists had assumed for […] (Source: Washington Post: To Your Health)

Persistent Neurologic Symptoms Common in Ebola Survivors Persistent Neurologic Symptoms Common in Ebola Survivors

Thu, 17 Mar 2016 03:11:45 +0100

Ebola survivors often report headaches, memory loss, depressed mood, muscle pain, and vision problems months after recovery, researchers are finding. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)

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Nerve cell stimulation 'may recall memories' in Alzheimer's patients

Wed, 16 Mar 2016 23:35:16 +0100

Research on mice has shown signs of reversing memory loss by using light to activate cells and help to grow new connectionsMemories banished by Alzheimer’s can in theory be rescued by stimulating nerve cells to grow new connections, a study has shown.The research, conducted in mice, raises the possibility of future treatments that reverse memory loss in early stages of the disease. Scientists used a technique called optogenetics, which uses light to activate cells tagged with a special photo-sensitive protein. Continue reading... (Source: Guardian Unlimited Science)

Flipping a light switch recovers memories lost to Alzheimer's disease mice

Wed, 16 Mar 2016 18:04:19 +0100

Light stimulation of brain cells can recover memories in mice with Alzheimer's disease-like memory loss, according to new research. The rescue of memories, which changed both the structure of neurons as well as the behavior of mice, was achieved using optogenetics, a method for manipulating genetically tagged cells with precise bursts of light. This finding suggests that impaired retrieval of memories, rather than poor storage or encoding, may underlie this prominent symptom of early Alzheimer's disease and points to the synaptic connectivity between memory cells as being crucial for retrieval. (Source: ScienceDaily Headlines)

Blood test could diagnose Alzheimer's disease in the middle-aged

Wed, 16 Mar 2016 10:22:59 +0100

There is at present no drug capable of stopping the physical onslaught of dementia (Source: Telegraph Health)

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

Wed, 16 Mar 2016 00:00:00 +0100

Nature advance online publication 16 March 2016. doi:10.1038/nature17172 Authors: Dheeraj S. Roy, Autumn Arons, Teryn I. Mitchell, Michele Pignatelli, Tomás J. Ryan & Susumu Tonegawa Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory decline and subsequent loss of broader cognitive functions. Memory decline in the early stages of AD is mostly limited to episodic memory, for which the hippocampus has a crucial role. However, it has been uncertain whether the observed amnesia in the early stages of AD is due to disrupted encoding and consolidation of episodic information, or an impairment in the retrieval of stored memory information. Here we show that in transgenic mouse models of early AD, direct optogenetic activation of hippocampal memory...

Suppressing traumatic memories can cause amnesia, research suggests

Tue, 15 Mar 2016 16:22:31 +0100

New study could explain why people suffering from PTSD and other psychological disorders can have difficulty forming everyday memoriesSuppressing bad memories from the past can block memory formation in the here and now, research suggests.The study could help to explain why those suffering from post-traumatic stress disorder (PTSD) and other psychological conditions often experience difficulty in remembering recent events, scientists say. Continue reading... (Source: Guardian Unlimited Science)

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Occupational exposure to ketamine detected by hair analysis: a retrospective and prospective toxicological study

Tue, 15 Mar 2016 00:00:00 +0100

Ketamine [2-(2-chlorophenyl)-2-methylamino-cyclohexan-1-one] (KT) is a synthetic molecule used as general anaesthetic as it produces a state of sedation, immobility, amnesia, analgesia and is often associated with other drugs to induce and maintain general anaesthesia [1]. It is frequently used in the veterinary field, however in humans prevalently used in children. Because of the hallucinogenic and dissociative effects, KT has become a substance of abuse, often used in different contexts like social, sexual and drug-related violence [2]. (Source: Forensic Science International)

Hospital revisit rate after a diagnosis of conversion disorder

Tue, 15 Mar 2016 00:00:00 +0100

Conclusions CD is associated with a substantial hospital revisit rate. Our findings suggest that CD is not an acute, time-limited response to stress, but rather that CD is a manifestation of a broader pattern of chronic neuropsychiatric disease. (Source: Journal of Neurology, Neurosurgery and Psychiatry)

Vestibular vertigo and comorbid cognitive and psychiatric impairment: the 2008 National Health Interview Survey

Tue, 15 Mar 2016 00:00:00 +0100

Conclusions Our findings indicate that vestibular impairment is associated with increased risk of cognitive and psychiatric comorbidity. The vestibular system is anatomically connected with widespread regions of the cerebral cortex, hippocampus and amygdala. Loss of vestibular inputs may lead to impairment of these cognitive and affective circuits. Further longitudinal research is required to determine if these associations are causal. (Source: Journal of Neurology, Neurosurgery and Psychiatry)

Get Cancer From Excess Estrogen in a Garden Hose?

Mon, 14 Mar 2016 14:54:04 +0100

Hormone-disrupting chemicals are among the most toxic substances in the world today. And they’ve permeated almost everything you eat, drink and even touch. Some chemicals, both natural and man-made, can interfere with our hormonal system. I’m talking about “estrogen mimickers” like Parabens and Bisphenol A (BPA) that are found in the coatings of food and drinks cans, water bottles, baby bottles, dental fillings and sealants, eyeglass lenses, DVDs and CDs, household electronic and sports equipment, receipts and even garden hoses. Mainstream medicine ignores the impact of these dangerous, gender-bending “xenoestrogens.” Yet they are responsible for a vast array of diseases disorders — including: Heart disease in men and women Type 2 diabetes Brain fog and memory loss, as a re...

Alcoholism and dementia.

Sat, 12 Mar 2016 04:45:03 +0100

Authors: van Gool WA Abstract The controversy concerning the concept 'alcoholic dementia' is reviewed in brief. Evidence from neuroradiological and neuropathological studies contribute little to the solution of this controversy, if dementia is considered as a clinical syndrome. From clinical descriptions it can be concluded that a sub-population of alcoholics suffers from a syndrome typified by psychologic disturbances other than amnesia alone. These patients fulfill the criteria for the syndromal diagnosis of 'dementia'. The nosologic concept of 'alcoholic dementia' implies a direct neurotoxic effect of alcohol and it raises questions concerning pathogenetic mechanisms which can not be answered. The DSM-III-R category 'dementia associated with alcoholism' represents a solution for...

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Barriers to and facilitators of diabetes self‐management with elderly Korean‐American immigrants

Fri, 11 Mar 2016 00:00:00 +0100

ConclusionsThe barriers to and facilitators of diabetes self‐management identified in this study can be used in the development of more age‐ and culturally sensitive diabetes interventions and resources. Implication for nursing and health policyNurses and healthcare providers can use this study's findings to develop patient‐centred, age‐appropriate and culturally appropriate diabetes interventions. There are urgent needs to train bilingual healthcare providers and staff and to provide translation services for Korean‐American elderly immigrants. Finally, communities and social supports within public health policy are urgently needed for this ethnic minority group. (Source: International Nursing Review)

Protective Effects of Colivelin Against Alzheimer's Disease in a PDAPP Mouse Model

Thu, 10 Mar 2016 20:34:14 +0100

Conclusion: CLN effectively improved the memory dysfunction in PDAPP mice, and our data suggests CLN as a novel and effective reagent which may have great potentials in AD therapy.Cell Physiol Biochem 2016;38:1138-1146 (Source: Cellular Physiology and Biochemistry)

Dilemmas surrounding the diagnosis of deep brain stimulation electrode infection without associated wound complications: A series of two cases.

Thu, 10 Mar 2016 19:23:02 +0100

CONCLUSIONS: Contrast enhancement, T2 FLAIR, and diffusion weighted imaging are influenced by postoperative changes. Caution is stressed regarding dependence on these features for acute diagnosis of infection and indication for electrode removal. Timing of the imaging after surgery must be considered. Other factors, such as systemic signs and abnormal laboratory data, should be evaluated. Based on these guidelines, retrospectively, the patient in Case 2 should not have been rushed for a wound exploration; close observation with serial imaging and laboratory data may have prevented an unnecessary procedure. PMID: 26958428 [PubMed] (Source: Surgical Neurology International)

Neglected Categorical Differences of Hypertension of the Elderly vs. the Young: A Case of Institutional Amnesia?

Thu, 10 Mar 2016 00:00:00 +0100

In the early 20th century, hypertension became a topic of major interest and by approximately the mid-century a number of investigators had identified a syndrome/condition in adults younger than 50 to 55 termed “essential hypertension” (sometimes “primary hypertension” or “hypertensive vascular disease”) (EHT). As then described and accepted by the medical community, individuals with EHT were understood to be distinct from those with hypertension with onset after approximately age 50 to 55 (“hypertension of the elderly”). (Source: Journal of the American Medical Directors Association)

The Abbreviated Westmead Post-traumatic Amnesia Scale and Pocket Concussion Recognition Tool: data from amateur sports players in live-match conditions - Hayter C, Meares S, Shores EA.

Tue, 08 Mar 2016 12:34:25 +0100

Sports-related concussion is a growing public health concern. A short, simple sideline assessment tool is essential for evaluation of concussion at an amateur participation level. The current study examined responses to sideline assessment measures in a sa... (Source: SafetyLit)

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Surgical techniques in radiation induced temporal lobe necrosis in nasopharyngeal carcinoma patients

Tue, 08 Mar 2016 00:00:00 +0100

Conclusion Neurosurgical intervention through a temporal approach with linear incision is warranted in patients with radiation induced temporal lobe necrosis with significant symptoms and signs of increased intracranial pressure, minimum space occupying effect on imaging, or neurological deterioration despite conservative management. (Source: Polish Journal of Neurology and Neurosurgery)

When Patients Are Close-Lipped About Memory Problems

Tue, 08 Mar 2016 00:00:00 +0100

Physicians can’t count on patients to raise concerns about memory loss at routine checkups, even when memory lapses infringe on daily living. (Source: JAMA)

Bad News Flash: Scientists Did Not Cure Autism, Cancer Or Alzheimer's

Mon, 07 Mar 2016 13:00:00 +0100

Recent headlines claimed that scientists have reversed autism, cured cancer, and restored memory loss caused by Alzheimer's. All of the headlines were based on real papers, but none of them are correct. Scientists and science journalists need to stop over-promising unless they just don't care about their credibility. (Source: Healthcare News)

The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer's disease-like cognitive deficit.

Mon, 07 Mar 2016 00:00:00 +0100

Authors: Gruden MA, Davydova TV, Wang C, Narkevich VB, Fomina VG, Kudrin VS, Morozova-Roche LA, Sewell RD Abstract Memory deficits may develop from a variety of neuropathologies including Alzheimer's disease dementia. During neurodegenerative conditions there are contributory factors such as neuroinflammation and amyloidogenesis involved in memory impairment. In the present study, dual properties of S100A9 protein as a pro-inflammatory and amyloidogenic agent were explored in the passive avoidance memory task along with neurochemical assays in the prefrontal cortex and hippocampus of aged mice. S100A9 oligomers and fibrils were generated in vitro and verified by AFM, Thioflavin T and A11 antibody binding. Native S100A9 as well as S100A9 oligomers and fibrils or their combination we...

Mother who suffered memory loss triggered when her heart stopped while she gave birth to her baby girl had to be reminded every ten minutes that she had a daughter

Sun, 06 Mar 2016 15:17:31 +0100

Louiser Chapman, 24, from Warnham, West Sussex, lost a litre of blood and was forced to have an emergency Caesarean when the placenta tore from her womb ten weeks before her due date. (Source: the Mail online | Health)

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A new method for assessing the impact of medial temporal lobe amnesia on the characteristics of generated autobiographical events.

Sun, 06 Mar 2016 00:00:00 +0100

Publication date: Available online 4 March 2016 Source:Neuropsychologia Author(s): Ariella Lenton-Brym, Jake Kurczek, Shayna Rosenbaum, Signy Sheldon Constructing autobiographical events involves an initial phase of event selection, in which a memory or imagined future event is initially brought to mind, followed by a phase of elaboration, in which an individual accesses detailed knowledge specific to the event. While considerable research demonstrates the importance of the medial temporal lobes (MTL) in the later phase, its role in initial event selection is unknown. The present study is the first to investigate the role of the MTL in event selection by assessing whether individuals with MTL lesions select qualitatively different events for remembering and imagining than matched con...

The Importance of Detoxification for Health

Fri, 04 Mar 2016 21:45:39 +0100

Spring is upon us, a perfect time of year for detoxification. As the seasons change, many of us are motivated to do 'spring cleaning' in our homes and gardens. The same need applies to our bodies. When the body is detoxified, it can function more efficiently and gain resilience. Physicians have been seeing increasing symptoms of toxicity in their patients over the last few decades. Hormone imbalances, obesity, mental fog, memory loss, fatigue, lack of vitality, metabolic syndrome, sleep disturbances are all manifestations of a toxic body. Conventional medicine does not acknowledge toxicity as an important health issue, but numerous studies have shown this to be the underlying cause of many chronic symptoms experienced today, including the rising rates of cancer over the past two decades....

Rhinitis in the Elderly

Fri, 04 Mar 2016 00:00:00 +0100

By 2050, the US aging population will nearly double. It will be increasingly important for health care providers to diagnose and manage rhinitis. Nasal symptoms of rhinorrhea, congestion, sneezing, nasal/ocular pruritus, and postnasal drainage affect up to 32% of older adults, and can impact quality of life. Several underlying factors associated with aging may contribute to the pathogenesis of rhinitis in older adults. Although treatment options for rhinitis exist, special considerations need to be made because comorbidities, limited income, memory loss, and side effects of medications are common in older adults and may impact outcomes. (Source: Immunology and Allergy Clinics of North America)

Intranasal midazolam administration enhances amnesic effect in rats

Fri, 04 Mar 2016 00:00:00 +0100

In this study, we examined the efficacy and the underlying mechanism of i.n. administration compared with intramuscular (i.m.) administration on midazolam-induced amnesia in rats. Equivalent doses of 0.6 mg/kg midazolam were administered via either the i.m or the i.n. route. Anterograde amnesia was assessed by a contextual/cued fear conditioning test. Each animal was conditioned 20 min after drug administration and then tested for a freezing response 24 h later. Midazolam administration by either route produced a similar level of light sedation (minimum spontaneous activity). However, i.n. administration of midazolam induced significantly less freezing behavior compared with i.m. midazolam. Furthermore, in rats with disrupted electrical input from the olfactory epithelium after an olfac...

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Brandi Chastain’s Decision To Donate Brain Is A Win For Women In Sport

Thu, 03 Mar 2016 17:22:26 +0100

Soccer legend Brandi Chastain has pledged to donate her brain for chronic traumatic encephalopathy research.  The 47-year-old, best known for her 1999 World Cup-winning penalty kick and the shirt-doffing celebration that followed, highlighted the move on Thursday as an important step in understanding how youth sports may affect development of CTE.  "If there’s any information to be gleaned off the study of someone like myself, who has played soccer for 40 years, it feels like my responsibility -- but not in a burdensome way," Chastain told The New York Times.  Conditions like CTE, which are linked to repetitive hits to the head, can only be diagnosed after death. It manifests itself in ways that can include cognitive disorders like memory loss and mood disord...

Medical News Today: Hostile attitude when young linked to memory problems later in life

Thu, 03 Mar 2016 08:00:00 +0100

People who display hostile attitudes as young adults, and who find it difficult to cope with stress, appear to experience more severe memory loss as they reach middle age. (Source: Health News from Medical News Today)

AC-3933, a benzodiazepine partial inverse agonist, improves memory performance in MK-801-induced amnesia mouse model

Thu, 03 Mar 2016 00:00:00 +0100

In this study, we further evaluated the procognitive effect of AC-3933 on memory impairment induced by MK-801, an N-methyl-d-aspartate receptor antagonist, in mice. Unlike the acetylcholinesterase inhibitor donepezil and the benzodiazepine receptor inverse agonist FG-7142, oral administration of AC-3933 significantly ameliorated MK-801-induced memory impairment in the Y-maze test and in the object location test. Interestingly, the procognitive effects of AC-3933 on MK-801-induced memory impairment were not affected by the benzodiazepine receptor antagonist flumazenil, although this was not the case for the beneficial effects of AC-3933 on scopolamine-induced memory deficit. Moreover, the onset of AC-3933 ameliorating effect on scopolamine- or MK-801-induced memory impairment was different ...

Key Mechanism Discovered in Alzheimer’s Disease-Related Memory Loss

Wed, 02 Mar 2016 22:04:53 +0100

A recent report in Nature Neuroscience reveals that a key mechanism has been discovered in Alzheimer’s disease-related memory loss. Dartmouth researchers Bryan Luikart, PhD, and Mark Spaller, PhD, talk about these groundbreaking findings and their implications for better understanding and treating Alzheimer’s. (Source: News at Dartmouth Medical School)

Medical News Today: Chronic stress leads to brain inflammation and memory loss

Wed, 02 Mar 2016 17:00:00 +0100

Stress caused by an aggressive alpha intruder caused memory loss in mice that lasted up to 28 days, accompanied by signs of inflammation in the brain. (Source: Health News from Medical News Today)

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Long-term anxiety causes inflammation in the brain that leads to memory loss

Tue, 01 Mar 2016 23:49:11 +0100

Researchers from Ohio State University found long-term stress (stock image pictured) can cause memory loss and inflammation in the brain - and the immune system is to blame. (Source: the Mail online | Health)

Feeling stressed can make you forgetful: Long-term anxiety causes inflammation in the brain that leads to memory loss

Tue, 01 Mar 2016 22:00:56 +0100

Researchers from Ohio State University found long-term stress (stock image pictured) can cause memory loss and inflammation in the brain - and the immune system is to blame. (Source: the Mail online | Health)

Can DSM-5 Correct Its Mistakes? I Say No, DSM-5 Says Yes

Tue, 01 Mar 2016 15:57:01 +0100

DSM-5 stirred great public and professional controversy because it was so carelessly done and included so many obvious mistakes. At the time, the American Psychiatric Association tried to appease critics with the promise that the errors not picked up before DSM-5 publication would promptly be corrected after. DSM-5 was advertised as a "living document", not written in stone and was to be subject to constant revision and updating. Critics took little consolation in this promise that DSM-5 errors might eventually be corrected. With more time, clearer thinking, and competent text editing, the DSM-5 mistakes could and should have been identified and corrected before its publication. But APA was in an anxious rush to get DSM-5 to press, however rough its form. DSM-5 is a publishing cash cow nec...

Ebola survivors left with brain problems

Tue, 01 Mar 2016 08:00:00 +0100

Lasting symptoms include headache, muscle pain, memory loss and depression, Liberian study reveals. (Source: SciDev.Net)

Time to Follow Commands and Duration of Posttraumatic Amnesia Predict GOS-E Peds Scores 1 to 2 Years After TBI in Children Requiring Inpatient Rehabilitation

Tue, 01 Mar 2016 06:00:00 +0100

Conclusion: Above and beyond the influence of GCS, TFC, PTA, and TFC + PTA are important predictors of later outcome after TBI. (Source: The Journal of Head Trauma Rehabilitation)

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A Case-control Study Examining the Characteristics of Patients who Fall in an Inpatient Traumatic Brain Injury Rehabilitation Setting

Tue, 01 Mar 2016 06:00:00 +0100

Conclusions: A patient in the rehabilitation setting with a more severe TBI characterized by multisystem impairments is at an increased risk of falling, whereas some traditional fall risk factors were not associated with patients who fall. Rehabilitation settings should consider cohort-specific fall risk profiling. The Ontario STRATIFY Falls Risk Screening Tool is perhaps not the best tool to screen for falls in this inpatient population. (Source: The Journal of Head Trauma Rehabilitation)

Comparing Prospectively Recorded Posttraumatic Amnesia Duration With Retrospective Accounts

Tue, 01 Mar 2016 06:00:00 +0100

Conclusions: Prospective and retrospective estimates of PTA duration were not comparable within the present sample. Further research comparing the two methods is needed. (Source: The Journal of Head Trauma Rehabilitation)

Diagnosis of Transverse Sinus Hypoplasia in Magnetic Resonance Venography: New Insights Based on Magnetic Resonance Imaging in Combined Dataset of Venous Outflow Impairment Case–Control Studies: Post Hoc Case–Control Study

Tue, 01 Mar 2016 06:00:00 +0100

Abstract: In previous studies of transverse sinus (TS) hypoplasia, discrepancies between TS diameter measured by magnetic resonance venography (MRV) and contrast T1-weighted magnetic resonance (contrast T1) were observed. To investigate these discrepancies, and considering that TS hypoplasia is associated with neurological disorders, we performed a post hoc analysis of prospectively collected data from 3 case–control studies on transient global amnesia (TGA), transient monocular blindness (TMB), and panic disorders while retaining the original inclusion and exclusion criteria. Magnetic resonance (MR) imaging of 131 subjects was reviewed to evaluate TS diameter and the location and degree of venous flow stenosis and obstruction. MRV without contrast revealed that TS hypoplasia was observ...

Model of anaesthetic induction by unilateral intracerebral microinjection of GABAergic agonists

Tue, 01 Mar 2016 00:00:00 +0100

This study considers the alternative that anesthesia reflects recruitment of dedicated neuronal pathways. We show that delivery of minute quantities of anesthetic agents directly to a particular brainstem locus, unilaterally, rapidly induces an anesthetic state suggesting that clinical anesthesia also works by accessing this locus. (Source: European Journal of Neuroscience)

Does distracting pain justify performing brain computed tomography in multiple traumas with mild head injury?

Tue, 01 Mar 2016 00:00:00 +0100

Abstract Traumatic brain injury (TBI) is a significant health concern classified as mild, moderate, and severe. Although the indications to perform brain computed tomography (CT) are clear in moderate and severe cases, there still exists controversy in mild TBI (mTBI). We designed the study to evaluate the significance of distracting pain in patients with mTBI. The study population included patients with mild traumatic brain injury (GCS ≥13). Moderate and high risk factors including age <18 months or ≥60 years, moderate to severe or progressive headache, ≥2 episodes of vomiting, loss of consciousness (LOC), post-traumatic amnesia, seizure or prior antiepileptic use, alcohol intoxication, previous neurosurgical procedures, uncontrolled hypertension, anticoagulant use, pr...

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Benzodiazepine Use Reduces Cortical Beta-Amyloid Levels and is Not Associated with Progressive Cognitive Decline in Non-Demented Elderly Adults: A Pilot Study Using F18 -Florbetapir Positron Emission Tomography

Tue, 01 Mar 2016 00:00:00 +0100

Introduction: Benzodiazepines (BZDs) are among the most commonly used psychotropics for anxiety, agitation, and insomnia in the elderly population. The adverse effects of BZDs on memory, including anterograde amnesia and impairment on long-term memory, have been well documented. However, studies investigating the effects of BZD use on progressive cognitive decline in elderly adults and increased risk of dementia yield conflicting results. While there are several epidemiological studies showing elevated incidence of cognitive decline and risk of dementia in BZD users, other findings suggest that BZD use is not associated with cognitive impairment or increased incidence of dementia in elderly individuals. (Source: The American Journal of Geriatric Psychiatry)

Dopaminergic neurotransmission dysfunction induced by β-amyloid transforms cortical LTP into LTD and produces memory impairment

Mon, 29 Feb 2016 00:00:00 +0100

Alzheimer's disease (AD) is a neurodegenerative condition manifested by synaptic dysfunction and memory loss, but the mechanisms underlying synaptic failure are not entirely understood. Even though dopamine is a key modulator of synaptic plasticity, dopaminergic neurotransmission dysfunction in AD has mostly been associated to non-cognitive symptoms. Thus, we aimed to study the relationship between dopaminergic neurotransmission and synaptic plasticity in AD models. We used a transgenic model of AD (3xTg-AD) and the administration of exogenous Amyloid-β oligomers into WT mice. (Source: Neurobiology of Aging)

Into the future with little past: exploring mental time travel in a patient with damage to the mammillary bodies/fornix.

Mon, 29 Feb 2016 00:00:00 +0100

CONCLUSIONS: This dissociation of past and future events' performance after mammillary body and fornix damage is at odds with the findings of the majority of patients with adult onset hippocampal amnesia. It suggests that these non-hippocampal regions of the Papez circuit are only critical for past event retrieval and not for the generation of possible future events. PMID: 26928513 [PubMed - as supplied by publisher] (Source: The Clinical Neuropsychologist)

Medications May Cause Dementia, But It Could Be Untreated Sleep Apnea

Sat, 27 Feb 2016 18:58:37 +0100

By Brandon R. Peters, M.D. The news was enough to give you indigestion: Some of the over-the-counter and prescription medications most widely used to treat heartburn and acid reflux are linked to the development of dementia. The research suggesting a possible association is the latest in a string of implicated drugs over the past few years, including medications taken to treat anxiety, seizures, insomnia, and allergies. What is going on? Before emptying out the medicine cabinet, take a moment to consider the role of untreated obstructive sleep apnea. Scientific research can be difficulty to contextualize, especially when it is splashing around in headlines or restricted to a sound bite. Nuance is lost. The complexity of the topic may not be fully conveyed. Researchers themselves may not fu...

Post-traumatic amnesia and confusional state: hazards of retrospective assessment - Friedland D, Swash M.

Sat, 27 Feb 2016 13:08:11 +0100

Retrospective assessment of post-traumatic amnesia (PTA) must take into account factors other than traumatic brain injury (TBI) which may impact on memory both at the time of injury and subsequent to the injury. These include analgesics, anaesthesia requir... (Source: SafetyLit)

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Assessing for mild TBI among Iraq and Afghanistan veterans: Outcomes of injury severity and neurological factors.

Fri, 26 Feb 2016 16:47:06 +0100

CONCLUSIONS: Identification of neurologic symptoms that most contribute to a clinician-confirmed diagnosis of TBI has potential for streamlining detection of TBI and symptoms needed for treatment. PMID: 26910483 [PubMed - as supplied by publisher] (Source: Brain Injury)

News From the SOCIETY

Fri, 26 Feb 2016 01:36:20 +0100

Join your AMDA friends and colleagues on Saturday, March 19, at 5:45 p.m. in the Convention Center’s Osceola Ballroom A for a free screening of Alive Inside, an award-winning film featuring annual conference closing keynote speaker Dan Cohen, MSW, founder of Music & Memory. This documentary is an exploration of music’s capacity to reawaken souls and uncover the deepest parts of our humanity. It shows Mr. Cohen in action as he demonstrates music’s ability to combat memory loss and restore a deep sense of self to those suffering from it. (Source: Caring for the Ages)

Postconcussion syndrome: demographics and predictors in 221 patients.

Fri, 26 Feb 2016 00:00:00 +0100

CONCLUSIONS PCS is commonly associated with multiple concussions, but 23.1% in the present series occurred after only 1 concussion. Most patients with PCS had multiple symptoms persisting for months or years. The median duration of PCS was 7 months, with a range up to 26 years. In only 11.3%, the PCS had ended at the time of consultation. Not all predictors commonly cited in the literature align with the findings in this study. This is likely due to differences in the definitions of PCS used in research. These results suggest that the use of ICD-10 and DSM-IV to diagnose PCS may be biased toward those who are vulnerable to concussions or with more severe forms of PCS. It is thus important to redefine PCS based on evidence-based medicine. PMID: 26918481 [PubMed - as supplied by publishe...

Ebola survivors face long-term neurological problems, researchers find

Thu, 25 Feb 2016 14:28:43 +0100

Study undertaken in Liberia suggests Ebola virus has lasting impact on the brain of survivors, causing headache, memory loss and depressed mood Ebola survivors are continuing to suffer from neurological problems more than six months after infection, according to the early results of a new study.The findings from research undertaken by US neurologists in Liberia appear to confirm suspicions that there are serious long-term effects of Ebola virus disease. They have been made public days after Pauline Cafferkey, the nurse who contracted Ebola while working as a volunteer in Sierra Leone, was admitted for the third time to the infectious diseases unit of the Royal Free hospital. Continue reading... (Source: Guardian Unlimited Science)

Challenges in the pharmacological management of epilepsy and its causes in the elderly

Thu, 25 Feb 2016 00:00:00 +0100

Publication date: April 2016 Source:Pharmacological Research, Volume 106 Author(s): Edoardo Ferlazzo, Chiara Sueri, Sara Gasparini, Umberto Aguglia Epilepsy represents the third most common neurological disorders in the elderly after cerebrovascular disorders and dementias. The incidence of new-onset epilepsy peaks in this age group. The most peculiar aetiologies of late-onset epilepsy are stroke, dementia, and brain tumours. However, aetiology remains unknown in about half of the patients. Diagnosis of epilepsy may be challenging due to the frequent absence of ocular witnesses and the high prevalence of seizure-mimics (i.e. transient ischemic attacks, syncope, transient global amnesia or vertigo) in the elderly. The diagnostic difficulties are even greater when patients have cogniti...

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Ebola May Leave Lasting Neurological Problems

Wed, 24 Feb 2016 22:16:51 +0100

Six months after active illness, headaches, memory loss, depression were still being reported (Source: WebMD Health)

Chapter Three Ion Channels in Neurological Disorders

Wed, 24 Feb 2016 00:00:00 +0100

Publication date: 2016 Source:Advances in Protein Chemistry and Structural Biology, Volume 103 Author(s): Pravir Kumar, Dhiraj Kumar, Saurabh Kumar Jha, Niraj Kumar Jha, Rashmi K. Ambasta The convergent endeavors of the neuroscientist to establish a link between clinical neurology, genetics, loss of function of an important protein, and channelopathies behind neurological disorders are quite intriguing. Growing evidence reveals the impact of ion channels dysfunctioning in neurodegenerative disorders (NDDs). Many neurological/neuromuscular disorders, viz, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, amyotrophic lateral sclerosis, and age-related disorders are caused due to altered function or mutation in ion channels. To maintain cell homeostasi...

An Open-Label, Pilot Study of Daily Right Unilateral Ultrabrief Pulse Electroconvulsive Therapy

Tue, 23 Feb 2016 17:21:14 +0100

Abstract: Right unilateral ultrabrief (RUL-UB) pulse width electroconvulsive therapy (ECT) has attracted much research attention recently due to its smaller effect on memory than is associated with other forms of ECT, such as bitemporal placement or unilateral standard pulse width. However, RUL-UB has demonstrated slower antidepressant efficacy in comparison to the other techniques. One method to enhance the speed of response to RUL-UB ECT is administration of 5 times a week (termed “daily”) treatments as opposed to the more standard twice or thrice weekly schedule. In this open label study, we treated 20 depressed patients with daily RUL-UB treatments for up to 2 weeks (ie, 10 treatments) using standardized assessments of depression and retrograde amnesia. Response and remission rates...

Autobiographical Memory Specificity in Major Depression Treated With Electroconvulsive Therapy

Tue, 23 Feb 2016 17:21:14 +0100

Conclusions: We found reduced specificity of episodic autobiographical memory in depressed patients before ECT, which persisted at long-term follow-up despite significant improvement in mood. The finding of no detectable retrograde amnesia likely reflects lack of sensitivity of the recent life section of the AMI to detect ECT-induced changes. (Source: The Journal of ECT)

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Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

Tue, 23 Feb 2016 00:00:00 +0100

This article highlights recent findings in the role of Drp1 in AD pathogenesis. This article also highlights Drp1 and its relationships to glycogen synthase kinase 3, cyclin-dependent kinase 5, p53, and microRNAs in AD pathogenesis. (Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease)

Shock study finds memory loss could be linked to HERPES rather than old age

Mon, 22 Feb 2016 15:15:59 +0100

FORGETFULNESS is generally accepted as part of getting older, but new research suggests it could actually be caused by a common virus contracted in our younger years. (Source: Daily Express - Health)

Recovered recall memory after decompression of the fornix by surgical removal of pineal tumor

Mon, 22 Feb 2016 00:00:00 +0100

A 45-year-old woman had a 6-month history of progressive amnesia and diplopia. At age 34, a pineal germinoma was diagnosed; whole-brain radiation induced tumor regression for 10 years. The tumor had recurred and at surgery it was detached from the fornix and resected through an occipital transtentorial approach (figure 1). The fornix was decompressed and amnesia was remarkably recovered (figure 2A). (Source: Neurology)

Anti-leucine-rich glioma-inactivated 1 limbic encephalitis: A case report and literature review.

Sat, 20 Feb 2016 10:15:03 +0100

This study describes the case of a 41-year-old woman admitted for anterograde memory loss, right facial grimacing and right arm posturing that had begun 1 month previously. Cranial magnetic resonance-diffusion weighted imaging and -fluid-attenuated inversion recovery imaging revealed a hyperintense signal in the left hippocampus and right basal ganglia, but no contrast enhancement. An electroencephalogram revealed rhythmic sharp and slow waves and rhythmic θ build-ups in the left temporal area. Single-photon emission computed tomography showed increased regional blood flow perfusion in the left cerebral frontal lobe and the right basal ganglia. The cerebrospinal fluid was normal, with the exception of the presence of leucine-rich glioma-inactivated 1 (LGI1) antibodies, and LGI1 antibodies...

Traumatic Brain Injury Links Football Players to King Henry VIII

Fri, 19 Feb 2016 14:41:32 +0100

By now, you've probably heard of the neurodegenerative disease chronic traumatic encephalopathy (CTE), most popularly linked to football players who receive multiple sub-concussive blows to the head. Briefly, CTE is a type of traumatic brain injury. The disease can be spurred on by symptomatic concussions as well as sub-concussive hits to the head that do not cause immediate symptoms. CTE is characterized by degradation of brain tissue and the accumulation of tau protein, causing symptoms such as memory loss, aggression, confusion and deep depression that can appear years after initial brain trauma. Dr. Bennet Omalu is often credited with discovering and naming CTE in 2002 during the autopsy of a former NFL player. But while the words "chronic traumatic encephalopathy" are fairly new in s...

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The Cholinergic Signaling Responsible for the Expression of a Memory‐Related Protein in Primary Rat Cortical Neurons

Fri, 19 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Cellular Physiology)

Too Much Netflix and Chill Could Be Shrinking Your Brain

Thu, 18 Feb 2016 21:58:19 +0100

This article originally appeared on Inverse. By Yasmin Tayag Binge-watching all episodes of Making a Murderer might seem like a great idea this weekend, but a new study published in Neurology suggests your utter laziness might be linked to brain shrinkage in your later years. The study, led by researchers at the Boston University School of Medicine, found a direct correlation between poor fitness and brain volume decades later, using data taken over the course of 20 years. The 1,500 forty-somethings enrolled in the Framingham Heart Study took two treadmill tests, 20 years apart, to measure their peak VO2 -- the maximum amount of oxygen the body can use in a minute. At the time of the second exercise test, researchers took brain scans of the participants using an MRI to assess brain aging....

Memory effects of sedative drugs in children and adolescents—protocol for a systematic review

Thu, 18 Feb 2016 00:00:00 +0100

Discussion To the best of our knowledge, there is no systematic review that specifically addresses this question. Findings from the review will be useful in the decision-making process about the best sedative for minimizing recall of the medical/dental event and possible psychological trauma. Systematic review registration PROSPERO CRD42015017559 (Source: Systematic Reviews)

Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin.

Thu, 18 Feb 2016 00:00:00 +0100

In this study, we identified naturally occurring autoantibodies against Aβ oligomers (NAbs-Aβo), which were purified by Aβ42 oligomer or Cibacron Blue affinity chromatography from IVIG and termed as Oli-NAbs and Blue-NAbs, respectively. Oli-NAbs and Blue-NAbs recognized Aβ42 oligomers or both Aβ40 and 42 oligomers, differently. Both antibodies inhibited Aβ42 aggregation and attenuated Aβ42-induced cytotoxicity. Compared with vehicles, Oli-NAbs, Blue-NAbs and IVIG significantly improved the memory and cognition, and reduced the soluble and oligomeric Aβ levels in APPswe/PS1dE9 transgenic mice. Further investigation showed that Blue-NAbs at increased doses effectively decreased plaque burden and insoluble Aβ levels, whereas Oli-NAbs significantly declined the microgliosis and astrog...

Abstract P1-10-20: Importance of the patient voice in drug development: Early-stage breast cancer and measurement gaps concerning the treatment experience

Thu, 18 Feb 2016 00:00:00 +0100

Conclusion: Treatment-related symptoms and associated degree of bother differed by treatment group. Pts' descriptions of treatment impact provided additional insight into the burden of EBC. EBC-specific PROs included in trials that gain pts' perspective on experience with treatment would further inform pts and may also inform therapy choice.Citation Format: Petersen JA, Gauthier MA, Piault E, DeBusk KPA, Buzaglo JS, Eng-Wong J, Glazer JR, Green MC, Johnson JM, Spears PA, Evans CJ. Importance of the patient voice in drug development: Early-stage breast cancer and measurement gaps concerning the treatment experience. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;7...

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Man remembers who he was after 30 years of amnesia

Wed, 17 Feb 2016 20:27:20 +0100

It sounds like it's straight out of a soap opera, but this bizarre scenario played out in real life (Source: Health News:

Epigenetic Manipulation of Brain-derived Neurotrophic Factor Improves Memory Deficiency Induced by Neonatal Anesthesia in Rats

Wed, 17 Feb 2016 16:34:30 +0100

Conclusions The findings of this study elucidated the epigenetic mechanism underlying memory deficiency induced by neonatal anesthesia and propose EE as a potential therapeutic approach. (Source: Anesthesiology)

Challenges in the pharmacological management of epilepsy and its causes in the elderly.

Wed, 17 Feb 2016 00:00:00 +0100

Publication date: Available online 16 February 2016 Source:Pharmacological Research Author(s): Edoardo Ferlazzo, Chiara Sueri, Sara Gasparini, Umberto Aguglia Epilepsy represents the third most common neurological disorders in the elderly after cerebrovascular disorders and dementias. The incidence of new-onset epilepsy peaks in this age group. The most peculiar aetiologies of late-onset epilepsy are stroke, dementia, and brain tumours. However, aetiology remains unknown in about half of the patients. Diagnosis of epilepsy may be challenging due to the frequent absence of ocular witnesses and the high prevalence of seizure-mimics (i.e. transient ischemic attacks, syncope, transient global amnesia or vertigo) in the elderly. The diagnostic difficulties are even greater when patients h...

Can You Really Bottle Energy?

Tue, 16 Feb 2016 18:57:40 +0100

You see it almost everywhere these days — energy drinks that advertise the wonder of B vitamins. And they all claim to give you the energy boost to get you through your day. Sadly, it’s a big marketing ploy. The quick energy in these drinks usually comes from their high sugar and synthetic caffeine content. It’s true that B vitamins are essential to your body’s energy metabolism. And B12 in particular is crucial for energy. When you take in high-quality B12, you unlock the energy contained in the foods you eat and turn it into glucose you can burn. But fortified junk food is no way to get your vitamins. In a minute, I’m going to show you a better way. But let’s take a look at how important vitamin B12 really is — especially as you age. First of all, your body’s ability to ...

Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments.

Tue, 16 Feb 2016 03:38:03 +0100

This study demonstrates that ellagic acid is effective in preventing scopolamine- and diazepam-induced cognitive impairments without altering the animals' locomotion. This suggests the potential of EA application as a useful memory restorative agent in the treatment of dementia seen in elderly persons. PMID: 26828763 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)

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Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer's disease.

Tue, 16 Feb 2016 03:37:02 +0100

Authors: Drolle E, Hane F, Lee B, Leonenko Z Abstract Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by dementia and memory loss for which no cure or effective prevention is currently available. Neurodegeneration in AD is linked to formation of amyloid plaques found in brain tissues of Alzheimer's patients during post-mortem examination. Amyloid plaques are composed of amyloid fibrils and small oligomers - insoluble protein aggregates. Although amyloid plaques are found on the neuronal cell surfaces, the mechanism of amyloid toxicity is still not well understood. Currently, it is believed that the cytotoxicity is a result of the nonspecific interaction of small soluble amyloid oligomers (rather than longer fibrils) with the plasma membrane. In rec...

10 Memory Tips for Individuals With Alzheimer's Disease

Mon, 15 Feb 2016 15:07:55 +0100

Whether you are in the early stages of Alzheimer's disease, you are caring for, or you know someone with this condition, one of the scariest parts of this disease is the memory loss. When memory loss first becomes noticeable it can be frustrating, emotional and overwhelming for everyone involved. Many people take every memory-lapse as a sign that their condition is worsening and it can make handling dementia and Alzheimer's disease even more challenging. While there are certain treatments that can slow down the progression of dementia, one of the many things that individuals with Alzheimer's can do is to start implementing a few strategies that will help them with their memory. Leave yourself reminders around the home with sticky notes. Leave all of your emergency numbers and the names and...

Early onset drinking predicts greater level but not growth of alcohol-induced blackouts beyond the effect of binge drinking during emerging adulthood - Marino EN, Fromme K.

Mon, 15 Feb 2016 03:23:22 +0100

BACKGROUND: Early onset drinking is associated with later heavy drinking and related consequences. Early drinking onset and binge drinking are also independently associated with blackouts, which are periods of amnesia for events during a drinking episode. ... (Source: SafetyLit)

Long-term outcomes after moderate-to-severe traumatic brain injury among military veterans: Successes and challenges.

Sun, 14 Feb 2016 18:19:03 +0100

CONCLUSIONS: After moderate-severe TBI, most veterans assume productive roles and are satisfied with life. However, widespread difficulties and functional limitations persist. These findings suggest that veteran and military healthcare systems should continue periodic, comprehensive follow-up evaluations long after moderate-to-severe TBI. PMID: 26853377 [PubMed - as supplied by publisher] (Source: Brain Injury)

Injury of the dentato-rubro-thalamic tract in a patient with mild traumatic brain injury.

Sun, 14 Feb 2016 18:19:03 +0100

CONCLUSIONS: This study demonstrated injury of the DRTT in a patient with tremor and ataxia following mild TBI, using DTT. It is believed that analysis of the DRTT using DTT would be useful in elucidating the cause of post-traumatic abnormal movements. PMID: 26479208 [PubMed - in process] (Source: Brain Injury)

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Loss of recent memory after bilateral hippocampal lesions: memory and memories--looking back and looking forward

Sun, 14 Feb 2016 00:00:00 +0100

In 1957, Scoville and Milner reported a series of case studies describing the nature of the memory defect they observed following bilateral surgical removals from the medial temporal region. The paper highlighted that extensive bilateral surgical excisions from the hippocampus and hippocampal gyrus resulted in severe and lasting memory loss; it also focused attention on these brain structures as critical for the maintenance of normal memory function. These findings ran counter to prevailing views at the time by linking a memory disturbance to damage to a specific part of the brain, and highlighted the fact that the hippocampal region was essential in the establishment of new and enduring memories. Milner had been invited to study this series of patients by the neurosurgeon, William Scovill...

Is obesity linked to memory loss?

Fri, 12 Feb 2016 12:00:00 +0100

Researchers from Alabama publish a study in The Journal of Neuroscience which showed that obesity in mice was linked the epigenetic suppression of four genes associated with memory formation. Scientific American (Source: Society for Endocrinology)

Sleep apnea takes a toll on brain function

Fri, 12 Feb 2016 00:28:26 +0100

One in 15 adults has moderate to severe obstructive sleep apnea, a disorder in which a person’s breathing is frequently interrupted during sleep — as many as 30 times per hour. People with sleep apnea also often report problems with thinking such as poor concentration, difficulty with memory and decision-making, depression, and stress. According to new research from the UCLA School of Nursing,  published online in the Journal of Sleep Research,  people with sleep apnea show significant changes in the levels of two important brain chemicals, which could be a reason that many have symptoms that impact their day-to-day lives. UCLA researchers looked at levels of these neurotransmitters — glutamate and gamma-aminobutyric acid, known as GABA — in a brain region called the insula, wh...

The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice

Thu, 11 Feb 2016 00:00:00 +0100

Publication date: Available online 10 February 2016 Source:Pharmacological Research Author(s): Gian Marco Leggio, Maria Vincenza Catania, Daniela Puzzo, Michela Spatuzza, Rosalia Pellitteri, Walter Gulisano, Sebastiano Alfio Torrisi, Giovanni Giurdanella, Cateno Piazza, Agata Rita Impellizzeri, Lucia Gozzo, Andrea Navarria, Claudio Bucolo, Ferdinando Nicoletti, Agostino Palmeri, Salvatore Salomone, Agata Copani, Filippo Caraci, Filippo Drago The ectopic re-activation of cell cycle in neurons is an early event in the pathogenesis of Alzheimer’s disease (AD), which could lead to synaptic failure and ensuing cognitive deficits before frank neuronal death. Cytostatic drugs that act as cyclin-dependent kinase (CDK) inhibitors have been poorly investigated in animal models...

Drinking patterns of adolescents who develop alcohol use disorders: results from the Victorian Adolescent Health Cohort Study

Thu, 11 Feb 2016 00:00:00 +0100

Conclusions Our results extend previous work by showing that patterns of drinking that represent loss of control over alcohol consumption (however expressed) are important targets for intervention. In addition to current policies that may reduce overall consumption, emphasising prevention of more extreme teenage bouts of alcohol consumption appears warranted. (Source: BMJ Open)

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Wernicke Encephalopathy: Challenges in Diagnosis and Treatment: Report of 2 Cases.

Thu, 11 Feb 2016 00:00:00 +0100

CONCLUSIONS: There is no consensus about dosage, frequency, route, and duration of thiamine administration in WE treatment. Based on our cases, we recommend treating patients with WE with higher doses of IM thiamine for a longer time than suggested (900-1200 mg/d for 1-2 months, in our cases) and to gradually reduce dosage after clinical and radiological improvement, maintaining IM 200 mg/d dosage for at least 1 year. PMID: 26869612 [PubMed - as supplied by publisher] (Source: Nutrition in Clinical Practice)

5 tips to help teens stay heart healthy

Mon, 08 Feb 2016 14:03:14 +0100

As parents, we want our kids to stay healthy throughout their lives. The teen years are an important time to build healthy cardiovascular habits. In 2010, the American Heart Association set the bold goal of improving the cardiovascular health of all Americans by 20 percent. In setting this goal, they created a paradigm shift from the treatment of cardiovascular disease to the promotion of cardiovascular health. Their recommendation was based on more than a decade of data showing adults who reach middle age without any major cardiovascular disease risk factors have a high chance of staying healthy well into old age. They don’t just have lower rates of heart disease and stroke; they also have lower rates of cancer, memory loss and kidney disease. What is cardiovascular health? The American...

Early Onset Drinking Predicts Greater Level But Not Growth of Alcohol‐Induced Blackouts Beyond the Effect of Binge Drinking During Emerging Adulthood

Mon, 08 Feb 2016 00:00:00 +0100

ConclusionsEarly onset drinkers reported more frequent blackouts across all 3 years, indicating that early alcohol initiation predisposes those individuals to continue to experience more frequent blackouts, despite a decrease in their binge drinking. This may be due to various factors, such as altered hippocampal development and functioning resulting from early alcohol exposure. Early‐onset drinkers both experienced more frequent blackouts at Year 4 and continued to experience greater levels of blackouts over time, but they did not exhibit differential growth or change in reported blackouts, despite the fact that the time‐varying effect of binge drinking on blackouts decreased across the three years. These findings indicate that there are likely unique neurobiological factors contrib...

Amnesia of the Operating Room in the B-Unaware and BAG-RECALL Clinical Trials.

Mon, 08 Feb 2016 00:00:00 +0100

CONCLUSIONS: In hospitals where patients typically receive midazolam in the preoperative holding area, the majority of patients do not remember the OR, and a clinically relevant number of patients does not remember the preoperative holding area. If additional studies produce results indicating that a substantial proportion of patients has amnesia of the anesthesiologist, these findings would argue against the validity of assessing patient satisfaction with individual anesthesiologists providing exclusively OR care in such hospitals. Furthermore, if additional studies yield findings suggesting patient amnesia of the preoperative holding area, these results would suggest reconsideration of providing clinically important information only in the preoperative holding area. Older age and midazol...

Hippocampal neurogenesis: learning to remember

Sun, 07 Feb 2016 00:00:00 +0100

Publication date: Available online 6 February 2016 Source:Progress in Neurobiology Author(s): Orly Lazarov, Carolyn Hollands Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by progressive memory loss and cognitive dysfunction. It has become increasingly clear that while neuronal cell loss in the entorhinal cortex and hippocampus occurs in Alzheimer's disease, it is preceded by a long period of deficits in the connectivity of the hippocampal formation that contributes to the vulnerability of these circuits. Hippocampal neurogenesis plays a role in the maintenance and function of the dentate gyrus and hippocampal circuitry. This review will examine the evidence suggesting that hippocampal neurogenesis plays a role in cognitive function that is af...

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Additive effect of BLA GABAA receptor mechanism and (+)-MK-801 on memory retention deficit, an isobologram analysis

Sat, 06 Feb 2016 00:00:00 +0100

In conclusion, muscimol and bicuculline decreased retention of memory formation in the BLA, and GABAA receptors in the BLA may be involved in the additive effect on (+)-MK-801-induced memory retention deficits. (Source: Pharmacology Biochemistry and Behavior)

Memory Matters: A Mixed-Methods Feasibility Study of a Mobile Aid to Stimulate Reminiscence in Individuals With Memory Loss.

Thu, 04 Feb 2016 00:00:00 +0100

Authors: Hamel AV, Sims TL, Klassen D, Havey T, Gaugler JE Abstract Reminiscence interventions are potentially effective in improving well-being of persons with memory loss (PWMLs) and may also enhance relationships with family and professional caregivers. Using a parallel convergent mixed-methods design, the feasibility of "Memory Matters," (MM) a mobile device application developed to promote reminiscence, was evaluated. Eighteen PWMLs and eight family members were enrolled from a long-term care facility and asked to use MM for 4 weeks. Participants were observed using MM at enrollment and 2 weeks and completed 1-month interviews. Six staff participants also completed a system review checklist and/or focus group at 1 month. Three qualitative domains were identified: (a) context o...

The Jekyll and Hyde of Statins

Wed, 03 Feb 2016 21:17:06 +0100

By Drs. David Niesel and Norbert Herzog, Medical Discovery News Cholesterol-lowering drugs called statins are the most prescribed drug ever. About 30 percent of Americans are currently taking statins such as Crestor, Lipitor, Mevacor and Zocor. Overall, statins can be good thing, but as with all drugs, there are some negative effects. Statins lower cholesterol by inhibiting a protein called HMG-CoA reductase. Since high cholesterol levels are linked to heart disease, statins can reduce the risks of heart attack and stroke, two of the leading causes of death in the United States. Recent reports from the American Heart Association and the American College of Cardiology even argue that more people should be taking statins. They want everyone with a 7.5 percent or higher risk of developing hea...

Weight loss in middle age: A warning sign of dementia?

Wed, 03 Feb 2016 12:30:00 +0100

ConclusionThis study has investigated the association between weight change in midlife and the risk of MCI in older age. The study found that participants who developed MCI in later life experienced a slightly greater weight loss per decade in middle age than those who did not. This effect was seen in the group as a whole and for men, but was not significant for women. The main thing to note is that the researchers are not trying to blame the weight change itself on the increased risk of MCI, just that it could be a marker. The researchers suggest that weight loss may have been due to what is called the "anorexia of ageing". This is said to be a dysfunction in the production of certain hormones, which then affects dietary intake and energy metabolism, which could in theory affect...

O‐GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

Wed, 03 Feb 2016 00:00:00 +0100

In this study, we found that PKA catalytic subunits (PKAcs) were posttranslationally modified by O‐linked N‐acetylglucosamine (O‐GlcNAc). O‐GlcNAcylation regulated the subcellular location of PKAcα and PKAcβ and enhanced their kinase activity. Upregulation of O‐GlcNAcylation in metabolically active rat brain slices by O‐(2‐acetamido‐2‐deoxy‐d‐glucopyranosylidenamino) N‐phenylcarbamate (PUGNAc), an inhibitor of N‐acetylglucosaminidase, increased the phosphorylation of tau at the PKA site, Ser214, but not at the non‐PKA site, Thr205. In contrast, in rat and mouse brains, downregulation of O‐GlcNAcylation caused decreases in the phosphorylation of CREB at Ser133 and of tau at Ser214, but not at Thr205. Reduction in O‐GlcNAcylation through intracerebroventricu...

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Cuba Gooding Jr. Thinks O.J. Simpson May Have CTE

Tue, 02 Feb 2016 22:04:02 +0100

After spending weeks portraying one of the most notorious football players of all time, Oscar-winning actor Cuba Gooding Jr. says he believes O.J. Simpson may suffer from chronic traumatic encephalopathy, or CTE. Gooding, who plays the former football star in "The People v. O.J. Simpson: American Crime Story," speculated about Simpson's mental state in a conversation with HuffPost Live on Monday. "I believe that after O.J. passes, if we have the opportunity to dissect his brain, we will find the CTE concussion syndrome," Gooding told host Alex Miranda. The degenerative disease, which was highlighted in the film "Concussion," is found among those who have suffered repetitive head trauma. CTE is linked with mood changes, memory loss and "explosive" behavior and has become a significant topic...

Cognitive-enhancing activities of the polyprenol preparation Ropren® in gonadectomized β-amyloid (25–35) rat model of Alzheimer's disease

Tue, 02 Feb 2016 00:00:00 +0100

Publication date: 1 April 2016 Source:Physiology & Behavior, Volume 157 Author(s): Julia Fedotova, Vagif Soultanov, Tamara Nikitina, Victor Roschin, Natalia Ordyan, Lucian Hritcu The present preclinical study was designed to examine the effects of prolonged Ropren® administration (8.6mg/kg, orally, once daily, 28days) in a β-amyloid (25–35) rat model of Alzheimer's disease following gonadectomy. The experimental model was created by intracerebroventricular injection of β-amyloid (25–35) into gonadectomized (GDX) rats and GDX rats with testosterone propionate (TP, 0.5mg/kg, subcutaneous, once daily, 28days) supplementation. Ropren® was administered to the GDX rats and GDX rats treated with TP. Memory performance was assessed using the passive avoidance and the Morris...

New Sunscreen Protects Against Skin Cancer, Allows Body To Produce Vitamin D

Mon, 01 Feb 2016 22:56:18 +0100

BOSTON (CBS) – Many people are getting the message loud and clear. That sunscreen helps protect you against skin cancer. But some experts say all that sunscreen is creating another problem. “That is the major cause for the vitamin D epidemic worldwide,” says Dr. Michael F. Holick, an endocrinologist at the BU School of Medicine. “Sunscreen absorbs ultraviolet light and ultraviolet light makes vitamin D in your skin, and if you put a sunscreen on with an SPF of 30 and it absorbs about 97-98% of the UV light, it will reduce the ability to make vitamin D in your skin by 97-98%,” says Dr. Willett. That can lead to a host of problems including rickets, osteoporosis, diabetes, and memory loss. So how can we get the cancer blocking effects of sunscreen without depriving our bodies ...

Pineal Diffuse Large B-Cell Lymphoma Concomitant With Pituitary Prolactinoma: Possible Correlation Between 2 Distinguished Pathologies: A Case Report

Mon, 01 Feb 2016 06:00:00 +0100

Abstract: This is the first reported case of pineal lymphoma with concomitant prolactin-producing pituitary adenoma. A 51-year-old male experienced worsening headaches accompanied by nausea, diplopia, and memory loss for 1 month. Cranial nerve examination revealed bilateral upward gaze limitation with convergence impairment, which is known as Parinaud syndrome. Magnetic resonance images revealed a mass in the pineal gland with a coexisting mass within the enlarged sella fossa. Hormone analysis revealed hyperprolactinemia. The pineal mass was removed without injuring the hypothalamus, brain stem, or any neighboring vessels. Pathology examination confirmed the diagnosis of diffuse large B-cell lymphoma (DLBCL) involving the pineal gland. After further studies, the pineal lymphoma was determ...

Fornix deep brain stimulation induced long-term spatial memory independent of hippocampal neurogenesis

Mon, 01 Feb 2016 00:00:00 +0100

Abstract Deep brain stimulation (DBS) is an established symptomatic treatment modality for movement disorders and constitutes an emerging therapeutic approach for the treatment of memory impairment. In line with this, fornix DBS has shown to ameliorate cognitive decline associated with dementia. Nonetheless, mechanisms mediating clinical effects in demented patients or patients with other neurological disorders are largely unknown. There is evidence that DBS is able to modulate neurophysiological activity in targeted brain regions. We therefore hypothesized that DBS might be able to influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters, which were validated to restore memory loss in a previous behavioral study, we ...

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Bilateral occipital strokes from an atherosclerotic trigeminal artery

Mon, 01 Feb 2016 00:00:00 +0100

A 58-year-old man with coronary disease presented with headache, confusion, and vision loss. On examination, he had retrograde and anterograde amnesia, superior homonymous quadrantanopias, and could not identify colors. MRI showed bilateral occipital infarcts involving the parahippocampal and lingual gyri (figure 1). CT angiography revealed a hypoplastic vertebrobasilar circulation, with a persistent right trigeminal artery supplying the rostral basilar artery (figure 2). Persistent fetal arteries may increase risk of atherogenesis due to increased turbulence.1 A rare cortical syndrome, new-onset achromatopsia with amnesia should provoke concern for top of the basilar syndrome.2 In this case, fetal artery intracranial atherosclerosis resulted in a "top of the trigeminal" syndrome. (Source:...