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MedWorm: Biotechnology



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Biotechnology



Last Build Date: Mon, 28 Mar 2016 06:34:33 +0100

 



Recent Advances in Elucidating Nematode Moulting - Prospects of Using Oesophagostomum dentatum as a Model.

Sun, 27 Mar 2016 23:51:02 +0100

Authors: Ondrovics M, Gasser RB, Joachim A Abstract There are major gaps in our knowledge of many molecular biological processes that take place during the development of parasitic nematodes, in spite of the fact that understanding such processes could lead to new ways of treating and controlling parasitic diseases via the disruption of one or more biological pathways in the parasites. Progress in genomics, transcriptomics, proteomics and bioinformatics now provides unique opportunities to investigate the molecular basis of key developmental processes in parasitic nematodes. The porcine nodule worm, Oesophagostomum dentatum, represents a large order (Strongylida) of socioeconomically important nematodes, and provides a useful platform for exploring molecular developmental processes...

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CDSCO plans surprise checks at drug manufacturing sites

Sun, 27 Mar 2016 21:40:59 +0100

The move comes amid growing concern about the quality of medicines made in India and demands for a tighter inspection mechanism by regulatory agencies. (Source: The Economic Times Healthcare and Biotech News)



Magnetic nanoparticles in cancer diagnosis and treatment: a review.

Sun, 27 Mar 2016 17:10:02 +0100

Authors: Fathi Karkan S, Mohammadhosseini M, Panahi Y, Milani M, Zarghami N, Akbarzadeh A, Abasi E, Hosseini A, Davaran S Abstract Diagnosis and treatment of lung cancer have been characterized with a variety of challenges. However, with the advancement in magnetic nanoparticle (MNP) technology, many challenges in the diagnosis and treatment of lung cancer are on the decline. The MNPs have led to many break-through in cancer therapy. This paper seeks to establish the role of MNPs in diagnosis and treatment of lung cancer. It proposes that the existing challenges in the diagnosis and treatment of lung cancer can be addressed through application of MNPs in the process. PMID: 27015806 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine and Biotechnology)



Ciprofloxacin HCl-loaded calcium carbonate nanoparticles: preparation, solid state characterization, and evaluation of antimicrobial effect against Staphylococcus aureus.

Sun, 27 Mar 2016 17:10:02 +0100

Authors: Maleki Dizaj S, Lotfipour F, Barzegar-Jalali M, Zarrintan MH, Adibkia K Abstract Ciprofloxacin HCl-loaded calcium carbonate (CaCO3) nanoparticles were prepared via a w/o microemulsion method and characterized by dynamic light scattering, scanning electron microscopy, X-ray powder diffraction (XRPD) analysis, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). The in vitro drug release profiles as well as antimicrobial effect against Staphylococcus aureus (S. aureus) were also evaluated. The antibacterial effect was studied using serial dilution technique to determine the minimum inhibitory concentration (MIC) of the nanoparticles and was confirmed by streak cultures. The mean particle size, drug loading and entrapment efficiency wer...



Evaluation of host-guest system to enhance the tamoxifen efficiency.

Sun, 27 Mar 2016 17:10:02 +0100

Authors: Heidari Majd M, Akbarzadeh A, Sargazi A Abstract Hydrophobic drugs can absorb as guest molecules inside the cavity of cyclodextrins as host sites. So, forming the drug-cyclodextrin complex can exert a profound effect on the physicochemical and biological properties of the drugs. According to these advantages, in this study, we synthesized the tamoxifen (TMX) loaded cyclodextrin (CD)-conjugated MNPs to evaluate simultaneously the cytotoxicity and sustained release as well as hepatoprotective effect of this nanomedicine. The average size of Fe3O4-DPA-PEG-CD-TMX NPs was approximately 31 nm. By energy-dispersive X-ray spectroscopy (EDS), it was revealed that Fe3O4 constitutes 14.34% of the composition of modified MNPs. In the other words, nearly 85% of Fe3O4-DPA-PEG-CD NPs a...



Development and characterization of embelin-loaded nanolipid carriers for brain targeting.

Sun, 27 Mar 2016 17:10:02 +0100

The objective of present work was to enquire the potential use of embelin-loaded nanolipid carriers for brain targeting. The average particle size and polydispersity index (PDI) of optimized formulation (F19) were found to be 152 ± 19.7 nm and 0.143 ± 0.023, respectively. Nanolipid carrier (NLC) was also significantly attenuated pentylenetetrazole (PTZ)-induced biochemical parameters in comparison to plain embelin that results in an increase in the level of malondialdehyde (MDA), nitrite, and reduction in the level of glutathione. From the results, it was concluded that embelin-NLCs developed as a beneficial carrier to achieve sustained release and brain targeting through nasal route. PMID: 27012597 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine...



USFDA observations on 2 units not to impact products: Natco

Sun, 27 Mar 2016 13:11:59 +0100

"The company has received 483 observations for both facilities and believes them to be of minor in nature," a statement said. (Source: The Economic Times Healthcare and Biotech News)

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Readers Respond to "World Changing Ideas"

Sun, 27 Mar 2016 11:30:00 +0100

Letters to the editor from the December 2015 issue of Scientific American editors@sciam.com -- Read more on ScientificAmerican.com (Source: Scientific American)



Stem Cell Therapy for Cats

Sun, 27 Mar 2016 08:12:37 +0100

Researchers have successfully used stem cells to treat cats with a debilitating mouth disease. The findings could translate into potential therapies for humans suffering from similar ailments. Ben... -- Read more on ScientificAmerican.com (Source: Scientific American)



Influence of protein bulk properties on membrane surface coverage during immobilization

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: 1 July 2016 Source:Colloids and Surfaces B: Biointerfaces, Volume 143 Author(s): Francesca Militano, Teresa Poerio, Rosalinda Mazzei, Emma Piacentini, Annarosa Gugliuzza, Lidietta Giorno Biomolecules immobilization is a key factor for many biotechnological applications. For this purpose, the covalent immobilization of bovine serum albumin (BSA), lipase from Candida rugosa and protein G on differently functionalized regenerated cellulose membranes was investigated. Dynamic light scattering and electrophoresis measurements carried out on biomolecules in solution indicated the presence of monomers, dimers and trimers for both BSA and protein G, while large aggregates were observed for lipase. The immobilization rate and the surface coverage on functionalized regenera...



First draft genome sequencing of indole acetic acid producing and plant growth promoting fungus Preussia sp. BSL10

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: 10 May 2016 Source:Journal of Biotechnology, Volume 225 Author(s): Abdul Latif Khan, Sajjad Asaf, Abdur Rahim Khan, Ahmed Al-Harrasi, Ahmed Al-Rawahi, In-Jung Lee Preussia sp. BSL10, family Sporormiaceae, was actively producing phytohormone (indole-3-acetic acid) and extra-cellular enzymes (phosphatases and glucosidases). The fungus was also promoting the growth of arid-land tree—Boswellia sacra. Looking at such prospects of this fungus, we sequenced its draft genome for the first time. The Illumina based sequence analysis reveals an approximate genome size of 31.4Mbp for Preussia sp. BSL10. Based on ab initio gene prediction, total 32,312 coding sequences were annotated consisting of 11,967 coding genes, pseudogenes, and 221 tRNA genes. Furthermore, 321 carbohy...



The Statistical Optimization of Bacterial Cellulose Production via Semi-Continuous Operation Mode

Sat, 26 Mar 2016 23:00:00 +0100

In this study, BC was produced in static culture using a semi-continuous operation mode; the conditions were optimized using response surface methodology (RSM). The collected BC was characterized by Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and tensile strength. Optimization parameters were selected as glucose concentration, surface area/volume ratio, surface area and incubation day intervals. The optimum values for incubation day intervals, volume changing ratios, glucose concentrations and surface area/volume ratios were 7 days, 66%, 50g/L and 1.22cm−1, respectively. BC productivity reached 0.284g/L/day under optimal conditions, while the model equation proposed 0.289g/L/day. RSM is essential for determining the optimum values of parameters fo...



Newton-Wellesley nurses avert strike with tentative agreement

Sat, 26 Mar 2016 15:10:15 +0100

The 974 nurses at Newton-Wellesley Hospital have averted a strike after coming to a tentative agreement on a contract on Friday. The union came close to announcing a strike, which the membership had voted to allow in mid-March. Had negotiations over a contract extended past today, a strike would have likely been imminent, the union said. The two-and-a-half-year agreement settles what was primarily a wage dispute, offering nurse a one percent increase retroactive to October, as well as two .5 percent… (Source: bizjournals.com Health Care:Biotechnology headlines)



First vaccine against Rota virus launched in India

Sat, 26 Mar 2016 08:45:36 +0100

The vaccine was launched in Odisha as the state records high diarrhoea cases among children and deaths due to improper treatment. (Source: The Economic Times Healthcare and Biotech News)



Recent advances in mycotoxins detection

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: 15 July 2016 Source:Biosensors and Bioelectronics, Volume 81 Author(s): Ruchika Chauhan, Jay Singh, Tushar Sachdev, T. Basu, B.D. Malhotra Mycotoxins contamination in both food and feed is inevitable. Mycotoxin toxicity in foodstuff can occur at very low concentrations necessitating early availability of sensitive and reliable methods for their detection. The present research thrust is towards the development of a user friendly biosensor for mycotoxin detection at both academic and industrial levels to replace conventional expensive chromatographic and ELISA techniques. This review critically analyzes the recent research trend towards the construction of immunosensor, aptasensor, enzymatic sensors and others for mycotoxin detection with a reference to label and lab...

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Combining expression and process engineering for high-quality production of human sialyltransferase in Pichia pastoris

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 25 March 2016 Source:Journal of Biotechnology Author(s): Christiane Luley-Goedl, Tibor Czabany, Karin Longus, Katharina Schmölzer, Sabine Zitzenbacher, Doris Ribitsch, Helmut Schwab, Bernd Nidetzky The human β-galactoside α2,6-sialyltransferase I, ST6Gal-I has drawn considerable interest for its use as biocatalyst for in vitro glycoengineering of recombinantly produced therapeutic proteins. By attaching sialic acid onto the terminal galactoses of biantennary protein N-glycans, ST6Gal-I facilitates protein remodeling towards a humanized glycosylation and thus optimized efficacy in pharmacological use. Secreted expression of ST6Gal-I in Pichia pastoris is promising, but proteolysis restricts both the yield and the quality of the enzyme produced...



Aims and Methods of Biosteganography

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 25 March 2016 Source:Journal of Biotechnology Author(s): Tyler D.P. Brunet Applications of biotechnology to information security are now possible and have potentially far reaching political and technological implications. This change in information security practices, initiated by advancements in molecular biological and biotechnology, warrants reasonable and widespread consideration by biologists, biotechnologists and philosophers. I offer an explication of the landmark contributions, developments and current possibilities of biosteganography—the process of transmitting secure messages via biological mediums. I address, i) how information can be stored and encoded in biological mediums, ii) how biological mediums (e.g. DNA, RNA, protein) and storage...



Optimization of peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) for the detection of bacteria: the effect of pH, dextran sulfate and probe concentration

Fri, 25 Mar 2016 23:00:00 +0100

This study shows that, for an optimum hybridization protocol, dextran sulfate and pH should be adjusted according to the target bacteria. (Source: Journal of Biotechnology)

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Human xanthine oxidase recombinant in E. coli: a whole cell catalyst for preparative drug metabolite synthesis

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 25 March 2016 Source:Journal of Biotechnology Author(s): Márcia Ferreira Antunes, Fabian Kurt Eggimann, Matthias Kittelmann, Stephan Lütz, Steven P. Hanlon, Beat Wirz, Thorsten Bachler, Margit Winkler Human xanthine oxidoreductase (XOR), which is responsible for the final steps of the purine metabolism pathway and involved in oxidative drug metabolism, was successfully expressed in Escherichia coli BL21(DE3) Gold. Recombinant human (rh) XOR yielded higher productivity with the gene sequence optimized for expression in E.coli than with the native gene sequence. Induction of XOR expression with lactose or IPTG resulted in complete loss of activity whereas shake flasks cultures using media rather poor in nutrients resulted in functional XOR expre...



Sensors, Vol. 16, Pages 446: Pedestrian Detection and Tracking from Low-Resolution Unmanned Aerial Vehicle Thermal Imagery

Fri, 25 Mar 2016 23:00:00 +0100

Driven by the prominent thermal signature of humans and following the growing availability of unmanned aerial vehicles (UAVs), more and more research efforts have been focusing on the detection and tracking of pedestrians using thermal infrared images recorded from UAVs. However, pedestrian detection and tracking from the thermal images obtained from UAVs pose many challenges due to the low-resolution of imagery, platform motion, image instability and the relatively small size of the objects. This research tackles these challenges by proposing a pedestrian detection and tracking system. A two-stage blob-based approach is first developed for pedestrian detection. This approach first extracts pedestrian blobs using the regional gradient feature and geometric constraints filtering and then cl...



Sensors, Vol. 16, Pages 447: Concrete Condition Assessment Using Impact-Echo Method and Extreme Learning Machines

Fri, 25 Mar 2016 23:00:00 +0100

The impact-echo (IE) method is a popular non-destructive testing (NDT) technique widely used for measuring the thickness of plate-like structures and for detecting certain defects inside concrete elements or structures. However, the IE method is not effective for full condition assessment (i.e., defect detection, defect diagnosis, defect sizing and location), because the simple frequency spectrum analysis involved in the existing IE method is not sufficient to capture the IE signal patterns associated with different conditions. In this paper, we attempt to enhance the IE technique and enable it for full condition assessment of concrete elements by introducing advanced machine learning techniques for performing comprehensive analysis and pattern recognition of IE signals. Specifically, we u...

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Sensors, Vol. 16, Pages 445: A Sensitive Secondary Users Selection Algorithm for Cognitive Radio Ad Hoc Networks

Fri, 25 Mar 2016 23:00:00 +0100

Secondary Users (SUs) are allowed to use the temporarily unused licensed spectrum without disturbing Primary Users (PUs) in Cognitive Radio Ad Hoc Networks (CRAHNs). Existing architectures for CRAHNs impose energy-consuming Cognitive Radios (CRs) on SUs. However, the advanced CRs will increase energy cost for their cognitive functionalities, which is undesirable for the battery powered devices. A new architecture referred to as spectral Requirement-based CRAHN (RCRAHN) is proposed to enhance energy efficiency for CRAHNs in this paper. In RCRAHNs, only parts of SUs are equipped with CRs. SUs equipped with CRs are referred to as Cognitive Radio Users (CRUs). To further enhance energy efficiency of CRAHNs, we aim to select minimum CRUs to sense available spectrum. A non-linear programming pro...



Sensors, Vol. 16, Pages 444: A Virtual Environment to Improve the Detection of Oral-Facial Malfunction in Children with Cerebral Palsy

Fri, 25 Mar 2016 23:00:00 +0100

The importance of an early rehabilitation process in children with cerebral palsy (CP) is widely recognized. On the one hand, new and useful treatment tools such as rehabilitation systems based on interactive technologies have appeared for rehabilitation of gross motor movements. On the other hand, from the therapeutic point of view, performing rehabilitation exercises with the facial muscles can improve the swallowing process, the facial expression through the management of muscles in the face, and even the speech of children with cerebral palsy. However, it is difficult to find interactive games to improve the detection and evaluation of oral-facial musculature dysfunctions in children with CP. This paper describes a framework based on strategies developed for interactive serious games t...



Sensors, Vol. 16, Pages 442: LS Channel Estimation and Signal Separation for UHF RFID Tag Collision Recovery on the Physical Layer

Fri, 25 Mar 2016 23:00:00 +0100

In a passive ultra-high frequency (UHF) radio-frequency identification (RFID) system, tag collision is generally resolved on a medium access control (MAC) layer. However, some of collided tag signals could be recovered on a physical (PHY) layer and, thus, enhance the identification efficiency of the RFID system. For the recovery on the PHY layer, channel estimation is a critical issue. Good channel estimation will help to recover the collided signals. Existing channel estimates work well for two collided tags. When the number of collided tags is beyond two, however, the existing estimates have more estimation errors. In this paper, we propose a novel channel estimate for the UHF RFID system. It adopts an orthogonal matrix based on the information of preambles which is known for a reader an...



Sensors, Vol. 16, Pages 443: A Survey on Security and Privacy in Emerging Sensor Networks: From Viewpoint of Close-Loop

Fri, 25 Mar 2016 23:00:00 +0100

Nowadays, as the next generation sensor networks, Cyber-Physical Systems (CPSs) refer to the complex networked systems that have both physical subsystems and cyber components, and the information flow between different subsystems and components is across a communication network, which forms a closed-loop. New generation sensor networks are found in a growing number of applications and have received increasing attention from many inter-disciplines. Opportunities and challenges in the design, analysis, verification and validation of sensor networks co-exists, among which security and privacy are two important ingredients. This paper presents a survey on some recent results in the security and privacy aspects of emerging sensor networks from the viewpoint of the closed-loop. This paper also d...



Influence of nutrient media on callus induction, somatic embryogenesis and plant regeneration in selected Turkish crocus species

Fri, 25 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Biotechnology Reports Author(s): Sandeep Kumar Verma, Ashok Kumar Das, Gunce Sahin Cingoz, Emel Uslu, Ekrem Gurel Callus induction, somatic embryogenesis and plant regeneration were initiated in selected five species of Turkish crocus using three diffrent explants (leaf, stem and corm) cultured on four different media (MS, GB5, LS and CHE). The highest frequencies of callus induction (100%) and shoot regeneration (70%, with 7.2 shoots/callus) were found in the crocus species Crocus oliveri ssp. Oliveri, using the MS medium containing 5% (w/v) sucrose supplemented with (4mg/L NAA+4mg/L TDZ) and (2mg/L IAA+2mg/L TDZ+2mg/L BAP). When the embryogenic calli were transferred into the four nutrient media containing (2mg/L IAA+2mg/L TD...

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Aurora to host Korean delegation to talk business, trade

Fri, 25 Mar 2016 22:22:33 +0100

The city of Aurora—together with Aurora Sister Cities International—will host a trade-focused delegation of Koreans from its sister city Seongnam City, Republic of Korea, from March 27-30. During their visit, Aurora Sister Cities International will host a one-day, private-sector business conference open to metro-area business owners. Among the delegates is Seongnam City Mayor Jae-myung Lee, city officials and 10 private-sector businesses who want to sell their products and discuss potential… (Source: bizjournals.com Health Care:Biotechnology headlines)



What’s at Anschutz? A directory of the medical campus

Fri, 25 Mar 2016 21:55:39 +0100

Here are key patient and clinical care, research and academic facilities at or adjacent to the University of Colorado Anschutz Medical Campus. (Organizations with multiple missions are listed under their core function.) HOSPITALS University of Colorado Hospital (UCH) — The Rocky Mountain region’s leading academic medical center. Its physicians are faculty of the CU School of Medicine. UCH houses the Anschutz Inpatient and Outpatient Pavilions and the University of Colorado Cancer Center. Children’s… (Source: bizjournals.com Health Care:Biotechnology headlines)



Phoenix Suns, Mercury, Iasis Healthcare open multi-specialty clinic in downtown Phoenix

Fri, 25 Mar 2016 21:19:22 +0100

The Phoenix Suns, Phoenix Mercury and Iasis Healthcare Corp. teamed up to open a $7.9 million Multi Specialty Clinic in downtown Phoenix. Housed in the former 28,000-square-foot Phoenix Suns Athletic Club, the facility also once was the Phoenix Mercantile Building. The building is on the southeast corner of the Talking Stick Resort Arena parking lot. Click on the photo of the brick building for a tour of the new clinic. This is the first of its kind multi-specialty clinic, offering a wide range… (Source: bizjournals.com Health Care:Biotechnology headlines)



Seattle scientists create blood test to predict tuberculosis

Fri, 25 Mar 2016 20:41:35 +0100

Scientists at Seattle’s Center for Infectious Disease Research and the University of Cape Town in South Africa have developed a blood test to predict whether latent tuberculosis will develop into active tuberculosis, a measure with implications for hundreds of millions of people worldwide. The 10-year project that culminated with the development of the test was funded in part by the Seattle-based Bill & Melinda Gates Foundation. What’s more, the Seattle connection is continuing with the University… (Source: bizjournals.com Health Care:Biotechnology headlines)



MedStar Georgetown hospital wins approval for $567M expansion

Fri, 25 Mar 2016 20:16:51 +0100

MedStar Georgetown University Hospital received approval for its $567 million plan to build a six-story hospital pavilion and renovate its existing hospital, District regulators said Friday. A regulatory panel recommended last week that the project receive a certificate of need — the regulatory approval required for medical facilitiles — and on Friday the director of the State Health Planning and Development Agency agreed. The hospital submitted its plan last July. MedStar officials intend… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Colorado AG agrees to conversion of InnovAge into for-profit business — with long list of stipulations

Fri, 25 Mar 2016 20:13:12 +0100

Colorado Attorney General Cynthia Coffman has given InnovAge the green light to convert from a nonprofit into a for-profit provider of elderly care — with a few stipulations. InnovAge operates six senior centers and a daycare program in Colorado, as well as has locations in New Mexico and California. The organization is a provider of PACE, a program through which individuals who are 55 years of age and older, eligible for Medicare and Medicaid, and a nursing home level of care can receive medical… (Source: bizjournals.com Health Care:Biotechnology headlines)



Breaking down the $950M Netsmart sale, and Allscripts' role

Fri, 25 Mar 2016 20:01:01 +0100

Netsmart Technologies Inc.’s management will have a small stake in the Overland Park, Kansas-based company after its sale — but it will play a huge role in the deal. A joint venture of San Francisco-based equity firm GI Partners and Chicago-based Allscripts Healthcare Solutions Inc. is buying Netsmart for $950 million. Although they’re buying nearly all of Netsmart, company management will have a small stake representing a bridge that keeps either of the two big investors from owning more… (Source: bizjournals.com Health Care:Biotechnology headlines)



Total Access Urgent Care to open Wentzville location

Fri, 25 Mar 2016 19:43:14 +0100

Total Access Urgent Care is opening another location, this time in Wentzville. The 5,000-square foot facility at 1890 Wentzville Parkway opens Thursday. It’s Total Access’ seventh location in the St. Louis region and is the first of about a half-dozen Dr. Matt Bruckel, president and founder of Total Access, is planning to add in the next year. Facilities in Ellisville and Creve Coeur will open in May and July, respectively. “We placed the patient back in the center of the patient care experience,”… (Source: bizjournals.com Health Care:Biotechnology headlines)



Breaking down the $950M Netsmart sale

Fri, 25 Mar 2016 19:21:47 +0100

Netsmart Technologies Inc.’s management will have a small stake in the Overland Park-based company after its sale — but it will play a huge role in the deal. A joint venture of San Francisco-based equity firm GI Partners and Chicago-based Allscripts Healthcare Solutions Inc. is buying Netsmart for $950 million. Although they’re buying nearly all of Netsmart, company management will have a small stake representing a bridge that keeps either of the two big investors from owning more than 50… (Source: bizjournals.com Health Care:Biotechnology headlines)



Sneak peek: Oakland's new Highland Hospital tower

Fri, 25 Mar 2016 19:20:22 +0100

Alameda Health System and Alameda County are about to burst with pride about the health system's new inpatient tower at Oakland's Highland Hospital. The county is investing at least $668 million to expand and upgrade the safety net hospital's campus, including the new nine-story, 169-bed Acute Care Tower, slated to open April 4. That overall price tag includes $40 million in equipment and furnishings, with $25 million included as part of the new inpatient facility. See the photos in the slideshow… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Why local investors put money in health care innovation beyond Nashville

Fri, 25 Mar 2016 19:20:19 +0100

Nashville's well-positioned to innovate in health care: We've got the nation's largest hospital companies, investors who made their money building and selling to those companies, and a bevy of creative, entrepreneurial-minded folks who can easily be convinced to turn their songwriting efforts into reshaping health care. That's the theory, anyways. And yes, it does hold truth, which is why most national write-ups of the city's growing tech sector point to the importance of health care (shortly after… (Source: bizjournals.com Health Care:Biotechnology headlines)



SA Police union vote threatens further divide with City Hall

Fri, 25 Mar 2016 19:11:18 +0100

The vote of no confidence by an overwhelming percentage of San Antonio Police Officers Association union members this week in San Police Chief William McManus has city leaders up in arms. It’s a move that is certain to put more distance between the city of San Antonio and union leadership, making it even more unlikely the two sides will strike a new collective bargaining agreement anytime soon. Based on city leaders’ reaction to the police union’s latest move, frustrations are mounting over… (Source: bizjournals.com Health Care:Biotechnology headlines)



Fairview drops out of Minnesota Hospital Association

Fri, 25 Mar 2016 19:10:34 +0100

Minnesota's fourth-largest health system has dropped out of the Minnesota Hospital Association (MHA). Fairview Health Services told the trade association two weeks ago it would end its membership for the year, but reconsider its decision in 2017, MHA spokeswoman Wendy Burt said. "We are disappointed. They were a very active member and we hope they return in 2017," she said. Minneapolis-based Fairview declined to comment on its departure. The move could mean less clout for the MHA, which advocates… (Source: bizjournals.com Health Care:Biotechnology headlines)



Triangle investors take note of Durham health care analytics startup

Fri, 25 Mar 2016 19:06:55 +0100

Durham-based health care analytics startup Bivarus has raised $2 million in a round co-led by Durham investment group Hatteras Venture Partners. Research Triangle Park-based Excelerate Health Ventures, an existing Bivarus investor, also led in the round. With the additional capital, Bivarus plans to hire another 10 employees in sales, marketing and product engineering. The company currently employs 11, meaning it would nearly double in size. Bivarus has developed a patient satisfaction survey for… (Source: bizjournals.com Health Care:Biotechnology headlines)



Why big data is big boon for health care

Fri, 25 Mar 2016 18:57:15 +0100

Big data is making health care more transparent, more accurate and more cost-effective. That was the message from health care executives at the recent Health Care of the Future conference presented by the Puget Sound Business Journal, where they discussed how massive amounts of detailed information can be used to produce more reliable figures tied to health care. “We think that the bigger the data, the better,” said Shakil Haroon, the CEO of Mpirica Health Analytics. Large volumes of data… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Could human organs be Maryland's next big manufacturing industry?

Fri, 25 Mar 2016 18:51:50 +0100

For the last several years, Martine Rothblatt has been positioning United Therapeutics to manufacture transplantable human organs. This week, the founder and CEO of the Maryland biotech cornerstone told the state's tech community to get ready for a new industry to sprout from the idea. "In the next 10 to 20 years, Maryland will be known as the state that pioneered the concept of organ manufacturing," Rothblatt said as she accepted a Lifetime Achievement Award Monday from the Tech Council of Maryland.… (Source: bizjournals.com Health Care:Biotechnology headlines)



Paper Diagnostic Tests Could Save Thousands of Lives

Fri, 25 Mar 2016 15:30:00 +0100

The technology for simple and inexpensive diagnostic medical tools is available. Here’s how to get it from the labs to the front lines -- Read more on ScientificAmerican.com (Source: Scientific American)



Scientists Synthesize Bacteria with Smallest Genome Yet

Fri, 25 Mar 2016 14:15:00 +0100

"Minimal" cell raises the stakes in race to harness life’s building blocks -- Read more on ScientificAmerican.com (Source: Scientific American)

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TURBOGEN: Computer-controlled vertically oscillating grid system for small-scale turbulence studies on plankton

Fri, 25 Mar 2016 13:26:15 +0100

In recent years, there has been a renewed interest in the impact of turbulence on aquatic organisms. In response to this interest, a novel instrument has been constructed, TURBOGEN, that generates turbulence in water volumes up to 13 l. TURBOGEN is fully computer controlled, thus, allowing for a high level of reproducibility and for variations of the intensity and characteristics of turbulence during the experiment. The calibration tests, carried out by particle image velocimetry, showed TURBOGEN to be successful in generating isotropic turbulence at the typical relatively low levels of the marine environment. TURBOGEN and its sizing have been devised with the long-term scope of analyzing in detail the molecular responses of plankton to different mixing regimes, which is of great importanc...



Atom-Thin Patch Could Help Control Diabetes--without Needles

Fri, 25 Mar 2016 13:00:00 +0100

Ultraslim graphene sensor monitors blood sugar levels through skin -- Read more on ScientificAmerican.com (Source: Scientific American)



Pressure mounts on biotech industry shill and chemical pesticide pusher Jon Entine to disclose his financial ties

Fri, 25 Mar 2016 06:00:00 +0100

(NaturalNews) A public interest watchdog group that focuses on ensuring truth and transparency in America's food system, is calling on a noted corporate Big Food and GMO defender to publicly reveal any sources of funding he receives.U.S. Right To Know (USRTK), in a recent press... (Source: NaturalNews.com)



Ted Cruz is another Monsanto shill

Fri, 25 Mar 2016 06:00:00 +0100

(NaturalNews) During a recent agricultural summit in Iowa, the fact that Ted Cruz chose to use the words "anti-science" and "zealot" to describe his stance on GMO, actually supports the fact that he is already BOUGHT by biotech, the most evil industry on the planet – which inserts... (Source: NaturalNews.com)



Energy co. with major Houston presence named America's Best Employer

Fri, 25 Mar 2016 01:08:36 +0100

Only one Houston-based entity even cracked the top 100 on Forbes’ 2016 “America’s Best Employers” list, but the No. 1 company on the list has a significant local presence. Findlay, Ohio-based Marathon Petroleum Corp. (NYSE: MPC) beat out the likes of Google, Costco and a variety of other beloved brands for the top spot. The company spun off from Houston-based Marathon Oil Corp. (NYSE: MRO) in 2011 and is now the country’s third-largest oil refiner. In 2013, Marathon bought BP’s Texas… (Source: bizjournals.com Health Care:Biotechnology headlines)

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[In Depth] Synthetic microbe has fewest genes, but many mysteries

Thu, 24 Mar 2016 23:00:00 +0100

When it comes to genome size, a rare Japanese flower, called Paris japonica, is the current heavyweight champ, with 50 times more DNA than humans. At the other end of the scale, there's now a new lightweight record-holder growing in petri dishes in southern California. This week in Science, researchers led by genome sequencing pioneer Craig Venter report engineering a bacterium to have the smallest genome—and the fewest genes—of any freely living organism, smaller than the flower's by a factor of 282,000. Known as Syn 3.0, the new organism has a genome whittled down to the bare essentials needed to survive and reproduce, just 473 genes. The microbe's streamlined genetic structure excites evolutionary biologists and biotechnologists, who anticipate adding genes back to it one by one to ...



Transcriptional signature induced by a metastasis‐promoting c‐Src mutant in a human breast cell line

Thu, 24 Mar 2016 23:00:00 +0100

Deletions at the C‐terminus of the proto‐oncogene protein c‐Src kinase are found in the viral oncogene protein v‐Src as well as in some advanced human colon cancers. They are associated with increased kinase activity and cellular invasiveness. Here, we analyzed the mRNA expression signature of a constitutively active C‐terminal mutant of c‐Src, c‐Src(mt), in comparison with its wild‐type protein, c‐Src(wt), in the human non‐transformed breast epithelial cell line MCF‐10A. We demonstrated previously that the mutant altered migratory and metastatic properties. Genome‐wide transcriptome analysis revealed that c‐Src(mt) de‐regulated the expression levels of approximately 430 mRNAs whose gene products are mainly involved in the cellular processes of migration and adh...



Structure and Function of Dimeric XdINV [Enzymology]

Thu, 24 Mar 2016 23:00:00 +0100

We present here its three-dimensional structure, which shows the expected bimodular arrangement and also a long extension of its C terminus that together with an N-linked glycan mediate the formation of an unusual dimer. The two active sites of the dimer are connected by a long crevice, which might indicate its potential ability to accommodate branched fructans. This arrangement could be representative of a group of GH32 yeast enzymes having the traits observed in XdINV. The inactive D80A mutant was used to obtain complexes with relevant substrates and products, with their crystals structures showing at least four binding subsites at each active site. Moreover, two different positions are observed from subsite +2 depending on the substrate, and thus, a flexible loop (Glu-334–His-343) is ...



Sensors, Vol. 16, Pages 434: Balance Improvement Effects of Biofeedback Systems with State-of-the-Art Wearable Sensors: A Systematic Review

Thu, 24 Mar 2016 23:00:00 +0100

Falls and fall-induced injuries are major global public health problems. Balance and gait disorders have been the second leading cause of falls. Inertial motion sensors and force sensors have been widely used to monitor both static and dynamic balance performance. Based on the detected performance, instant visual, auditory, electrotactile and vibrotactile biofeedback could be provided to augment the somatosensory input and enhance balance control. This review aims to synthesize the research examining the effect of biofeedback systems, with wearable inertial motion sensors and force sensors, on balance performance. Randomized and non-randomized clinical trials were included in this review. All studies were evaluated based on the methodological quality. Sample characteristics, device design ...

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Sensors, Vol. 16, Pages 440: Application of MEMS Accelerometers and Gyroscopes in Fast Steering Mirror Control Systems

Thu, 24 Mar 2016 23:00:00 +0100

In a charge-coupled device (CCD)-based fast steering mirror (FSM) tracking control system, high control bandwidth is the most effective way to enhance the closed-loop performance. However, the control system usually suffers a great deal from mechanical resonances and time delays induced by the low sampling rate of CCDs. To meet the requirements of high precision and load restriction, fiber-optic gyroscopes (FOGs) are usually used in traditional FSM tracking control systems. In recent years, the MEMS accelerometer and gyroscope are becoming smaller and lighter and their performance have improved gradually, so that they can be used in a fast steering mirror (FSM) to realize the stabilization of the line-of-sight (LOS) of the control system. Therefore, a tentative approach to implement a CCD-...



Sensors, Vol. 16, Pages 435: A Simple Interface for 3D Position Estimation of a Mobile Robot with Single Camera

Thu, 24 Mar 2016 23:00:00 +0100

In recent years, there has been an increase in the number of mobile robots controlled by a smart phone or tablet. This paper proposes a visual control interface for a mobile robot with a single camera to easily control the robot actions and estimate the 3D position of a target. In this proposal, the mobile robot employed an Arduino Yun as the core processor and was remote-controlled by a tablet with an Android operating system. In addition, the robot was fitted with a three-axis robotic arm for grasping. Both the real-time control signal and video transmission are transmitted via Wi-Fi. We show that with a properly calibrated camera and the proposed prototype procedures, the users can click on a desired position or object on the touchscreen and estimate its 3D coordinates in the real world...



Sensors, Vol. 16, Pages 441: Penetration Depth Measurement of Near-Infrared Hyperspectral Imaging Light for Milk Powder

Thu, 24 Mar 2016 23:00:00 +0100

This study was aimed at exploring the feasibility of quantifying penetration depth of NIR hyperspectral imaging light for milk powder. Hyperspectral NIR reflectance images were collected for eight different milk powder products that included five brands of non-fat milk powder and three brands of whole milk powder. For each milk powder, five different powder depths ranging from 1 mm–5 mm were prepared on the top of a base layer of melamine, to test spectral-based detection of the melamine through the milk. A relationship was established between the NIR reflectance spectra (937.5–1653.7 nm) and the penetration depth was investigated by means of the partial least squares-discriminant analysis (PLS-DA) technique to classify pixels as being milk-only or a mixture of milk and melamine. With ...



Sensors, Vol. 16, Pages 436: Delay/Disruption Tolerant Network-Based Message Forwarding for a River Pollution Monitoring Wireless Sensor Network Application

Thu, 24 Mar 2016 23:00:00 +0100

Communications from remote areas that may be of interest is still a problem. Many innovative projects applied to remote sites face communications difficulties. The GOLDFISH project was an EU-funded project for river pollution monitoring in developing countries. It had several sensor clusters, with floating WiFi antennas, deployed along a downstream river’s course. Sensor clusters sent messages to a Gateway installed on the riverbank. This gateway sent the messages, through a backhaul technology, to an Internet server where data was aggregated over a map. The communication challenge in this scenario was produced by the antennas’ movement and network backhaul availability. Since the antennas were floating on the river, communications could be disrupted at any time. Also, 2G/3G availabili...



Sensors, Vol. 16, Pages 438: An Evaluation of Sensor Performance for Harmful Compounds by Using Photo-Induced Electron Transfer from Photosynthetic Membranes to Electrodes

Thu, 24 Mar 2016 23:00:00 +0100

Rapid, simple, and low-cost screening procedures are necessary for the detection of harmful compounds in the effluent that flows out of point sources such as industrial outfall. The present study investigated the effects on a novel sensor of harmful compounds such as KCN, phenol, and herbicides such as 3-(3,4-dichlorophenyl)-1,1-dimethylurea (DCMU), 2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine (atrazine), and 2-N-tert-butyl-4-N-ethyl-6-methylsulfanyl-1,3,5-triazine-2,4-diamine (terbutryn). The sensor employed an electrode system that incorporated the photocurrent of intra-cytoplasmic membranes (so-called chromatophores) prepared from photosynthetic bacteria and linked using carbon paste electrodes. The amperometric curve (photocurrent-time curve) of photo-induced electron transfer...

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Sensors, Vol. 16, Pages 439: Improved Tuning Fork for Terahertz Quartz-Enhanced Photoacoustic Spectroscopy

Thu, 24 Mar 2016 23:00:00 +0100

We report on a quartz-enhanced photoacoustic (QEPAS) sensor for methanol (CH3OH) detection employing a novel quartz tuning fork (QTF), specifically designed to enhance the QEPAS sensing performance in the terahertz (THz) spectral range. A discussion of the QTF properties in terms of resonance frequency, quality factor and acousto-electric transduction efficiency as a function of prong sizes and spacing between the QTF prongs is presented. The QTF was employed in a QEPAS sensor system using a 3.93 THz quantum cascade laser as the excitation source in resonance with a CH3OH rotational absorption line located at 131.054 cm−1. A minimum detection limit of 160 ppb in 30 s integration time, corresponding to a normalized noise equivalent absorption NNEA = 3.75 × 10−11 cm−1W/Hz½, was achie...



Sensors, Vol. 16, Pages 432: Spectroscopic Terahertz Imaging at Room Temperature Employing Microbolometer Terahertz Sensors and Its Application to the Study of Carcinoma Tissues

Thu, 24 Mar 2016 23:00:00 +0100

A terahertz (THz) imaging system based on narrow band microbolometer sensors (NBMS) and a novel diffractive lens was developed for spectroscopic microscopy applications. The frequency response characteristics of the THz antenna-coupled NBMS were determined employing Fourier transform spectroscopy. The NBMS was found to be a very sensitive frequency selective sensor which was used to develop a compact all-electronic system for multispectral THz measurements. This system was successfully applied for principal components analysis of optically opaque packed samples. A thin diffractive lens with a numerical aperture of 0.62 was proposed for the reduction of system dimensions. The THz imaging system enhanced with novel optics was used to image for the first time non-neoplastic and neoplastic hum...



Sensors, Vol. 16, Pages 437: Leaf Chlorophyll Content Estimation of Winter Wheat Based on Visible and Near-Infrared Sensors

Thu, 24 Mar 2016 23:00:00 +0100

The leaf chlorophyll content is one of the most important factors for the growth of winter wheat. Visual and near-infrared sensors are a quick and non-destructive testing technology for the estimation of crop leaf chlorophyll content. In this paper, a new approach is developed for leaf chlorophyll content estimation of winter wheat based on visible and near-infrared sensors. First, the sliding window smoothing (SWS) was integrated with the multiplicative scatter correction (MSC) or the standard normal variable transformation (SNV) to preprocess the reflectance spectra images of wheat leaves. Then, a model for the relationship between the leaf relative chlorophyll content and the reflectance spectra was developed using the partial least squares (PLS) and the back propagation neural network....



Sensors, Vol. 16, Pages 433: Investigation on the Mechanical and Electrical Behavior of a Tuning Fork-Shaped Ionic Polymer Metal Composite Actuator with a Continuous Water Supply Mechanism

Thu, 24 Mar 2016 23:00:00 +0100

This paper presents an innovative tuning fork-shaped ionic polymer metal composite (IPMC) actuator. With an integrated soft strain gauge and water supply mechanism (WSM), the surface strain of the actuator can be sensed in situ, and providing a continuous water supply maintains the water content inside the IPMC for long-term operation in air. The actuator was fabricated using a micromachining technique and plated with a nickel electrode. The device performance was experimentally characterized and compared with an actuator without a WSM. A large displacement of 1.5 mm was achieved for a 6 mm-long prong with 7-V dc actuation applied for 30 s. The measured current was analyzed using an electrochemical model. The results revealed that the faradaic current plays a crucial role during operation,...



Sensors, Vol. 16, Pages 425: Capacity of Heterogeneous Mobile Wireless Networks with D-Delay Transmission Strategy

Thu, 24 Mar 2016 23:00:00 +0100

This paper investigates the capacity problem of heterogeneous wireless networks in mobility scenarios. A heterogeneous network model which consists of n normal nodes and m helping nodes is proposed. Moreover, we propose a D-delay transmission strategy to ensure that every packet can be delivered to its destination nodes with limited delay. Different from most existing network schemes, our network model has a novel two-tier architecture. The existence of helping nodes greatly improves the network capacity. Four types of mobile networks are studied in this paper: i.i.d. fast mobility model and slow mobility model in two-dimensional space, i.i.d. fast mobility model and slow mobility model in three-dimensional space. Using the virtual channel model, we present an intuitive analysis of the cap...

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Sensors, Vol. 16, Pages 429: Close-Range Tracking of Underwater Vehicles Using Light Beacons

Thu, 24 Mar 2016 23:00:00 +0100

This paper presents a new tracking system for autonomous underwater vehicles (AUVs) navigating in a close formation, based on computer vision and the use of active light markers. While acoustic localization can be very effective from medium to long distances, it is not so advantageous in short distances when the safety of the vehicles requires higher accuracy and update rates. The proposed system allows the estimation of the pose of a target vehicle at short ranges, with high accuracy and execution speed. To extend the field of view, an omnidirectional camera is used. This camera provides a full coverage of the lower hemisphere and enables the concurrent tracking of multiple vehicles in different positions. The system was evaluated in real sea conditions by tracking vehicles in mapping mis...



NPPA to settle disputes with drug makers for over-charging medicines

Thu, 24 Mar 2016 22:30:45 +0100

Cipla has been locked in battles with the NPPA in Allahabad, Bombay and Karnataka. In 2013, the SC transferred Cipla’s Bombay High Court petition to itself. (Source: The Economic Times Healthcare and Biotech News)



Peninsula biotech Portola sheds quarter of value after mixed late-stage study

Thu, 24 Mar 2016 21:32:40 +0100

A late-stage study of an experimental blood-thinning drug from Portola Pharmaceuticals Inc. failed, sending the company's stock swooning Thursday despite the company's pledge to submit the drug for approval later this year. The South San Francisco company's (NASDAQ: PTLA) betrixaban is designed to inhibit Factor Xa, which causes blood to clot. But the Phase III study of the oral drug narrowly failed to show that betrixaban was better for the sickest patients than a standard-of-care anticoagulant,… (Source: bizjournals.com Health Care:Biotechnology headlines)



Top 10 VC money recipients in the Bay Area in 2015

Thu, 24 Mar 2016 21:28:00 +0100

While many familiar names topped the list of the top 10 venture capital recipients in the Bay Area in 2015, there were some surprising ones that you may not have guessed — or even heard of. Airbnb, SoFi and Uber seized the top three spots, each garnering $1 billion or more in VC. However the secretive, big data startup Palantir Technologies — backed by the CIA — followed as a close fourth, with $879.83 million. Lyft and Pinterest each received more than $500 million, and rising companies… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Anorexia battle: Parents fight Blue Shield over coverage denial for 15-year-old daughter

Thu, 24 Mar 2016 20:25:39 +0100

It comes down to this: Renee and Tom Sudol say Blue Shield of California should cover their daughter Jenny's expensive residential care for anorexia, a severe eating disorder, arguing that it treats serious mental illness differently than a severe disease like cancer, in violation of mental health parity laws. Blue Shield says that such treatment wasn't medically necessary in this case . And state regulators agreed with the giant San Francisco health insurer. Over the last two and a half years,… (Source: bizjournals.com Health Care:Biotechnology headlines)



$37M sale: Investors pour more money into Redmond office market

Thu, 24 Mar 2016 20:01:01 +0100

For the second time this month, an East Coast investor has acquired a Redmond office property. Colony Realty Partners of Boston paid $36.9 million for the Offices at Riverpark, a five-story building at 15809 Bear Creek Parkway, public records show. The building is in the 8-year-old Riverpark complex, which is near Redmond Town Center and next to the site of a future light rail station. The complex also includes a large apartment building and a Hyatt House hotel. The seller, JMA Ventures of San… (Source: bizjournals.com Health Care:Biotechnology headlines)



Meet the 8 KC-area startups that pitched at InvestMidwest

Thu, 24 Mar 2016 20:00:28 +0100

Eight Kansas City-area companies have been pitching at the InvestMidwest Venture Capital Forum, which took place on Wednesday and Thursday in St. Louis. This year's forum features 45 high-growth companies from 15 states and one from Europe that will present their business plans to a coveted audience of top venture capitalists, investment bankers and corporate and private investors. The companies hail from the life sciences, technology, food, agriculture and bioenergy sectors and are seeking funding… (Source: bizjournals.com Health Care:Biotechnology headlines)



Siteman Cancer Center gets new tool to fight breast cancer

Thu, 24 Mar 2016 19:53:58 +0100

Siteman Cancer Center rolled out a new mammography Thursday. Equipped with 3-D digital technology, the van provides the same advanced imaging that patients receive at Siteman’s four St. Louis area mammography clinics. Washington University radiologists who specialize in breast imaging read all Siteman mammograms, whether in the van or at a clinic. “Mammography is known to reduce a woman’s risk of dying from breast cancer by an estimated 30-40 percent or more,” said Dr. Catherine Appleton,… (Source: bizjournals.com Health Care:Biotechnology headlines)



UCF creates 3 new degrees to meet local workforce demand

Thu, 24 Mar 2016 19:50:36 +0100

Two new master's degrees and one new bachelor's degree are coming to the University of Central Florida to help meet the local workforce demand. They include a master of science in biomedical engineering, a master of science in data analytics and a bachelor of science in entertainment management. UCF's board of trustees approved the creation of the three new degrees at a March 24 meeting. Here's a breakdown of each new degree: Biomedical engineering: This will teach students about the development… (Source: bizjournals.com Health Care:Biotechnology headlines)

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See inside: Presbyterian Manors' new west Wichita campus

Thu, 24 Mar 2016 19:43:03 +0100

The last pieces of a $35 million project to create a new westside campus for Wichita Presbyterian Manor are nearly complete. An indoor pool and fitness center are nearing completion on the organization’s campus near 13th Street North and Zoo Blvd. Those amenities are expected to open later this spring. Those will be in addition to other amenities on the campus, including libraries, multiple courtyards, various dining areas and patios or balconies for independent living units. “It’s about… (Source: bizjournals.com Health Care:Biotechnology headlines)



Destination Medical Center touts $152.4M in private investment

Thu, 24 Mar 2016 19:36:24 +0100

The Destination Medical Center project is about $48 million away from being able to tap into a deep pool of public funds set aside to support the Mayo Clinic-backed multibillion-dollar initiative. The board overseeing the DMC announced Thursday that the private sector invested $87.4 million in Rochester, Minn., last year. That brings the total amount invested in the city since 2013 to $152.4 million. To access public hundreds of millions of dollars in public funding, the DMC must demonstrate to… (Source: bizjournals.com Health Care:Biotechnology headlines)



Cancer Advance Boston Joins Leading Oncology Experts for a Networking...

Thu, 24 Mar 2016 19:07:02 +0100

Prominent academics, leaders of the biopharmaceutical industry and key investors will assemble on April 4th and 5th for Cancer Advance Boston, a networking conference of the Boston Biotech Conference...(PRWeb March 24, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13290274.htm (Source: PRWeb: Medical Pharmaceuticals)



Researcher improves crop performance with new biotechnology

Thu, 24 Mar 2016 18:59:32 +0100

Researchers have discovered a way to enhance a plant's tolerance to stress, which in turn improves how it uses water and nutrients from the soil. These improvements increase plant biomass and yield. This discovery could be instrumental in agriculture and food security by improving crop sustainability and performance. (Source: ScienceDaily Headlines)



Peninsula biotech Portola sheds quarter of value after mixed late-stage study

Thu, 24 Mar 2016 18:30:10 +0100

A late-stage study of an experimental blood-thinning drug from Portola Pharmaceuticals Inc. failed, sending the company's stock swooning Thursday despite the company's pledge to submit the drug for approval later this year. The South San Francisco company's (NASDAQ: PTLA) betrixaban is designed to inhibit Factor Xa, which causes blood to clot. But the Phase III study of the oral drug narrowly failed to show that betrixaban was better for the sickest patients than a standard-of-care anticoagulant,… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)



Maryland's next big manufacturing industry: Human organs, says Martine Rothblatt

Thu, 24 Mar 2016 18:01:54 +0100

For the last several years, Martine Rothblatt has been positioning United Therapeutics to manufacture transplantable human organs. This week, the founder and CEO of the Maryland biotech cornerstone told the state's tech community to get ready for a new industry to sprout from the idea. "In the next 10 to 20 years, Maryland will be known as the state that pioneered the concept of organ manufacturing," Rothblatt said as she accepted a Lifetime Achievement Award Monday from the Technology Council of… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)



Preliminary studies for the development of intranasal nanoemulsion containing CNS agent: emphasizing the utilization of cut and weigh method.

Thu, 24 Mar 2016 17:20:02 +0100

CONCLUSION: The results of validation studies for cut and weigh method suggests that it can be effectively used as an optimization method for the selection of nanoemulsion composition. PMID: 27007745 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine and Biotechnology)

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Preparation and characterization of PLGA-β-CD polymeric nanoparticles containing methotrexate and evaluation of their effects on T47D cell line.

Thu, 24 Mar 2016 17:20:02 +0100

Authors: Gorjikhah F, Azizi Jalalian F, Salehi R, Panahi Y, Hasanzadeh A, Alizadeh E, Akbarzadeh A, Davaran S Abstract Among all cancers that affect women, breast cancer has most mortality rate. It is essential to attain more safe and efficient anticancer drugs. Recent advances in medical nanotechnology and biotechnology have caused in novel improvements in breast and other cancer drug delivery. Methotrexate is an anticancer drug that prevents the dihydrofolate reductase enzyme, which inhibits in the formation of DNA, RNA and proteins which have poor water-solubility. For enhancing the solubility and stability of drugs in delivery systems, we used methotrexate-loaded PLGA- beta-cyclodextrin nanoparticles. The PLGA- beta-cyclodextrin nanoparticles were synthesized by a double emulsi...



Medical management of glaucoma: focus on ophthalmologic drug delivery systems of timolol maleate.

Thu, 24 Mar 2016 17:20:02 +0100

Authors: Sah AK, Suresh PK Abstract Eye is a vital organ of our body and any complication not only poses the risk of serious medical condition but also economic burden on the individual. Timolol maleate is one of the preferable therapeutic agents for the management of glaucoma. Globally, eye drops are among the most common and popular conventional formulations, but they are also associated with some limitations in terms of therapeutic response, bioavailability, dosing frequency and poor patient compliance. Present paper gives an overview of the drug delivery systems developed for management of glaucoma, advances and novel approaches with special emphasis on timolol drug delivery. PMID: 27002850 [PubMed - as supplied by publisher] (Source: Artificial Cells, Nanomedicine and Biot...



Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells.

Thu, 24 Mar 2016 17:20:02 +0100

Authors: Vural AC, Odabas S, Korkusuz P, Yar Sağlam AS, Bilgiç E, Çavuşoğlu T, Piskin E, Vargel İ Abstract Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6 mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cell...



Controlled release of curcumin from poly(HEMA-MAPA) membrane.

Thu, 24 Mar 2016 17:20:02 +0100

Authors: Caka M, Türkcan C, Aktaş Uygun D, Uygun M, Akgöl S, Denizli A Abstract In this work, poly(HEMA-MAPA) membranes were prepared by UV-polymerization technique. These membranes were characterized by SEM, FTIR, and swelling studies. Synthesized membranes had high porous structure. These membranes were used for controlled release of curcumin which is already used as folk remedy and used as drug for some certain diseases and cancers. Curcumin release was investigated for various pHs and temperatures. Optimum drug release yield was found to be as 70% at pH 7.4 and 37 °C within 2 h period. Time-depended release of curcumin was also investigated and its slow release from the membrane demonstrated within 48 h. PMID: 27002641 [PubMed - as supplied by publisher] (Source: ...



Enhanced brain targeting efficacy of Olanzapine through solid lipid nanoparticles.

Thu, 24 Mar 2016 17:20:02 +0100

Authors: Natarajan J, Baskaran M, Humtsoe LC, Vadivelan R, Justin A Abstract Olanzapine (OLZ) is a typical anti-psychotic drug, which is highly lipophilic in nature, belongs to Biopharmaceutical Classification System (BCS) class II category. Though OLZ is an effective agent in the treatment of Schizophrenia, but it exhibits poor bioavailability (57%) due to extensive first-pass metabolism resulted in high dose is required to achieve therapeutic concentration in brain. Emerging evidences are indicating that high dose administration of OLZ may cause Extrapyramidal symptoms (EPS) in the psychotic patients. Hence, the present study is designed to develop Olanzapine solid lipid (OLZ-SLNs) using minimal dose of OLZ thereby enhancing the brain efficacy as well as to reduce the side effect...

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The Top 10 Biotech Companies In The U.S.

Thu, 24 Mar 2016 13:31:00 +0100

(Source: Forbes.com Healthcare News)



People Inc. expands home care services

Thu, 24 Mar 2016 06:16:47 +0100

People Inc. is expanding its home health care program through a new contract with Erie County. People Home Health Care Services-Certified Inc. operates as a nonprofit affiliate of the larger agency, providing certified by the state to provide home health services for seniors and people with disabilities. The $250,582 contract was awarded through a competitive request for proposals with the Erie County Department of Social Services. People Inc.’s CHHA will provide nurse assessor services for the… (Source: bizjournals.com Health Care:Biotechnology headlines)



ASU researcher improves crop performance with new biotechnology

Thu, 24 Mar 2016 04:00:00 +0100

(Arizona State University) Researchers with Arizona State University's School of Life Sciences have discovered a way to enhance a plant's tolerance to stress, which in turn improves how it uses water and nutrients from the soil. These improvements increase plant biomass and yield. This discovery could be instrumental in agriculture and food security by improving crop sustainability and performance. (Source: EurekAlert! - Medicine and Health)

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UW recieves grant for mobile heath care technology in Africa

Thu, 24 Mar 2016 02:47:46 +0100

The University of Washington received a $250,000 grant this week to continue a project that allows pregnant women in remote Africa to access health care through text message. Dr. Jennifer Unger, an assistant professor at UW, has been working on this mobile health care technology since 2012. She is the primary investigator on the Mobile WACh program, which is named for the UW’s Global Center for Integrated Health of Women, Adolescents and Children. The new grant, awarded by Saving Lives at Birth,… (Source: bizjournals.com Health Care:Biotechnology headlines)



Sun Pharma, AstraZeneca tie up to sell latest anti-diabetes drug Dapagliflozin

Wed, 23 Mar 2016 23:46:46 +0100

Diabetes estimated to affect approximately 69.2 million people in India and more than 415 million people worldwide. (Source: The Economic Times Healthcare and Biotech News)



Will retire from Chairmanship of Sanofi India: Vijay Mallya

Wed, 23 Mar 2016 23:40:32 +0100

Vijay Mallya today announced he will retire as Chairman of Sanofi India and will not seek reelection as a director of the drug maker. (Source: The Economic Times Healthcare and Biotech News)



Doctor sues Banner Health for unlawful termination

Wed, 23 Mar 2016 23:30:03 +0100

Dr. Mark Starling, a former chief medical officer of Banner Health, has filed a wrongful termination lawsuit against the Phoenix health system. Starling, who was recruited to Banner in 2004 as CMO and received the Guardian Award from Banner Heart Hospital in 2014, began to notice problems when the 67-year-old was asked when he planned to retire. He alleges in the lawsuit that management tried to convince him to leave his role as CMO voluntarily. When he refused, he claims they began accusing him… (Source: bizjournals.com Health Care:Biotechnology headlines)

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Charge-tunable insertion process of carbon nanotubes into DNA nanotubes

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 23 March 2016 Source:Journal of Molecular Graphics and Modelling Author(s): Lijun Liang, Zhisen Zhang, Zhe Kong, Yong Liu, Jia-Wei Shen, Debing Li, Qi Wang Control over interactions with biomolecules holds the key of the applications of carbon nanotubes (CNTs) in biotechnology. Here we report a molecule dynamics study on the encapsulation process of different charged CNTs into DNA nanotubes. Our results demonstrated that insertion process of CNTs into DNA nanotubes are charge-tunable. The positive charged CNTs could spontaneously encapsulate and confined in the hollow of DNA nanotubes under the combination of electrostatic and vdW interaction in our ns scale simulation. The conformation of DNA nanotubes is very stable even after the insertion of ...



Separation and identification of candidate protein elicitors from the cultivation medium of Leptosphaeria maculans inducing resistance in Brassica napus

Wed, 23 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Biotechnology Progress)



Production strategies for active heme-containing peroxidases from E. coli inclusion bodies – a review

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 24 March 2016 Source:Biotechnology Reports Author(s): Britta Eggenreich, Melissa Willim, David Johannes Wurm, Christoph Herwig, Oliver Spadiut Heme-containing peroxidases are frequently used in medical applications. However, these enzymes are still extracted from their native source, which leads to inadequate yields and a mixture of isoenzymes differing in glycosylation which limits subsequent enzyme applications. Thus, recombinant production of these enzymes in Escherichia coli is a reasonable alternative. Even though production yields are high, the product is frequently found as protein aggregates called inclusion bodies (IBs). These IBs have to be solubilized and laboriously refolded to obtain active enzyme. Unfortunately, refolding yields are s...

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miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering

Wed, 23 Mar 2016 23:00:00 +0100

This study systematically identified novel target miRNAs during different phases and conditions of a biphasic fed-batch production process and functionally evaluated their potential for host cell engineering. (Source: Journal of Biotechnology)



Complete genome sequence of opine-utilizing Variovorax sp. strain PAMC28711 isolated from an Antarctic lichen

Wed, 23 Mar 2016 23:00:00 +0100

We report the complete genome sequence of Variovorax sp. strain PAMC28711 isolated from the Antarctic lichen Himantormia sp. Whole genome sequencing revealed opine oxidase- and octopine dehydrogenase-related gene clusters that are involved in octopine utilization. These data will lead to future genetic and biochemical studies on the unusual catabolic traits of opine and octopine utilization in extremely cold environments. (Source: Journal of Biotechnology)



Complete genome sequence of Frondihabitans sp. strain PAMC28766, a novel carotenoid-producing and radiation-resistant strain isolated from an Antarctic lichen

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 23 March 2016 Source:Journal of Biotechnology Author(s): So-Ra Han, Sang-Cheol Yu, Seunghyun Kang, Hyun Park, Tae-Jin Oh Here, we report the first complete genome sequence of Frondihabitans sp. strain PAMC28766, which was found to consist of three plasmids, one chromosome (4,345,897bp), and a series of genes involved in carotenoid biosynthesis and nucleotide excision repair. An analysis of the Frondihabitans sp. PAMC28766 genome will improve our understanding of the carotenoid biosynthesis pathway. Furthermore, the sequence data will provide novel insight into UV radiation-resistance in extremely cold environments. (Source: Journal of Biotechnology)



Complete genome of Zhongshania aliphaticivorans SM-2T, an aliphatic hydrocarbon-degrading bacterium isolated from tidal flat sediment

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 23 March 2016 Source:Journal of Biotechnology Author(s): Baolei Jia, Hye Im Jeong, Kyung Hyun Kim, Che Ok Jeon Zhongshania aliphaticivorans SM-2T, a degrader of aliphatic hydrocarbons, is a Gram-negative, rod-shaped, flagellated, facultatively aerobic bacterium. Here, we report the genome sequence of strain SM-2T, which has a size of 4,204,359bp with 44 tRNAs, 9 rRNAs, and 3,664 protein-coding genes. In addition, several genes encoding aliphatic hydrocarbon degraders (alkane 1-monooxygenase, haloalkane dehalogenase, and cytochrome P450) were detected in the genome shedding light on the function of pollutants degradation. (Source: Journal of Biotechnology)



Analysis and optimization of triacylglycerol synthesis in novel oleaginous Rhodococcus and Streptomyces strains isolated from desert soil

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 23 March 2016 Source:Journal of Biotechnology Author(s): Annika Röttig, Philippa Hauschild, Mohamed H. Madkour, Ahmed M. Al-Ansari, Naief H. Almakishah, Alexander Steinbüchel As oleaginous microorganisms represent an upcoming novel feedstock for the biotechnological production of lipids or lipid-derived biofuels, we searched for novel, lipid-producing strains in desert soil. This was encouraged by the hypothesis that neutral lipids represent an ideal storage compound, especially under arid conditions, as several animals are known to outlast long periods in absence of drinking water by metabolizing their body fat. Ten lipid-accumulating bacterial strains, affiliated to the genera Bacillus, Cupriavidus, Nocardia, Rhodococcus and Streptomyces, were...

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Evaluation of the genetic basis of heavy metal resistance in an isolate from electronic industry effluent

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 24 March 2016 Source:Journal of Genetic Engineering and Biotechnology Author(s): Manasi, N. Rajesh, Vidya Rajesh Halomonas BVR 1 isolated from an electronic industry effluent had high level of resistance to heavy metals like cadmium, lead, zinc and to various antibiotics. Minimum Inhibitory Concentration (MIC) of the strain toward cadmium and lead was found to be 200mgL−1 and 400mgL−1 respectively, while it could tolerate zinc up to 250mgL−1 and chromium up to 150mgL−1. The present study proved the genetic contribution of heavy metal resistance in this strain to be plasmid mediated. Isolation of the plasmid from Halomonas BVR 1 and its subsequent linearization with Bam H1 confirmed the presence of a plasmid of size >10kb. Plasmid curin...