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Preview: MedWorm: Stem Cell Therapy

MedWorm: Stem Cell Therapy News



MedWorm.com provides a medical RSS filtering service. Thousands of medical RSS feeds are combined and output via different filters. This feed contains the latest news in Stem Cell Therapy



Last Build Date: Sun, 18 Feb 2018 21:36:50 +0100

 



Breakthrough over growing human organs in animals

Sun, 18 Feb 2018 15:56:15 +0100

Scientists create hybrid embryos with stem cells from both species (Source: FT.com - Drugs and Healthcare)

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George Church: "Genome sequencing is like the internet back in the late 1980s."

Sun, 18 Feb 2018 07:30:38 +0100

The pioneering geneticist on why he wants us to earn money by sharing our genomic data, his plans to resurrect the woolly mammoth and how narcolepsy helps him generate ideas• How can I make money from my DNA?A new genetic testing company calledNebula Genomics wants to help people profit from their own genomes. The Observer talks to Harvard University DNA sequencing pioneer George Church about his latest venture, what ’s cooking in his lab and how falling asleep on the job can sometimes be a godsend.What is the value of getting your genome sequenced? Why do it?One very compelling argument that I think justifies almost everybody in the population getting sequenced is reproductive decision making: who to date, who to marry, whether or not to have gamete [egg/sperm] donors. Anybody that is...



A share in the future of DNA sequencing

Sun, 18 Feb 2018 07:30:38 +0100

Professor George Church on why he wants us to earn money by sharing our genomic data, his plans to resurrect the woolly mammoth and how narcolepsy helps him generate ideas• How can I make money from my DNA?A new genetic testing company calledNebula Genomics wants to help people profit from their own genomes. The Observer talks to Harvard University DNA sequencing pioneer George Church about his latest venture, what ’s cooking in his lab and how falling asleep on the job can sometimes be a godsend.What is the value of getting your genome sequenced? Why do it?One very compelling argument that I think justifies almost everybody in the population getting sequenced is reproductive decision making: who to date, who to marry, whether or not to have gamete [egg/sperm] donors. Anybody that is o...



We may all have stem cells stored on chips to test drugs

Sat, 17 Feb 2018 00:53:13 +0100

The staggering development could revolutionize the idea of 'personalized medicine' - and could also overhaul the drug approvals market. (Source: the Mail online | Health)



Scientists produce human intestinal lining that re-creates living tissue inside organ-chip

Fri, 16 Feb 2018 05:00:00 +0100

(The Yates Network) Scientists created human intestinal lining outside an individual ’ s body that mirrors living tissue inside microengineered Intestine-Chips, opening possibilities for personalized testing of medicines. The re-created intestinal lining, derived from an adult's cells that were converted into stem cells and grown into organoids, bore the adult's genetic fingerprint. The findings potentially could change how patients are treated for gastrointestinal diseases. The study was conducted by the Cedars-Sinai Board of Governors Regenerative Medicine Institute and Emulate, Inc. (Source: EurekAlert! - Medicine and Health)



Lab-grown human cerebellar cells yield clues to autism

Fri, 16 Feb 2018 05:00:00 +0100

(Boston Children's Hospital) Increasing evidence has linked autism spectrum disorder (ASD) with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD-like features. (Source: EurekAlert! - Medicine and Health)

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Induced Pluripotent Stem Cell Vaccine Promising for Cancer

Fri, 16 Feb 2018 01:00:00 +0100

iPSC vaccine prevented tumor growth in syngeneic murine breast CA, mesothelioma, melanoma models (Source: The Doctors Lounge - Oncology)



In mice, a single vaccine prompts the immune system to fight breast, lung and skin cancers

Thu, 15 Feb 2018 20:30:00 +0100

In the field of regenerative medicine, induced pluripotent stem cells have a lot of neat tricks up their sleeves. One of them may be teaching the immune system how to beat back cancer.In research that could open a new frontier in the young field of cancer immunotherapy, Stanford University scientists... (Source: Los Angeles Times - Science)



Stem cell cancer vaccine immunized mice against tumors

Thu, 15 Feb 2018 19:10:26 +0100

Researchers at Stanford University made personalized stem cell vaccines for mice. The stem cell shot, coupled with an immunity booster, shrank tumors in seven out of 10 of the mice. (Source: the Mail online | Health)



Medical News Today: Have scientists found an anti-cancer vaccine?

Thu, 15 Feb 2018 17:00:00 +0100

Researchers used stem cells to create an anti-cancer vaccine, which they tested in 75 mice with various types of cancer. Here's what they found. (Source: Health News from Medical News Today)



iPSC Derived Human Neural Progenitors

Thu, 15 Feb 2018 14:22:00 +0100

Potent, Pure and Easy to CultureWe are pleased to announce the addition of HumanNeural Progenitors to ourPrimary and Stem Cell offering.Human Neural Progenitors at 95% ConfluencyCell potency, for us, includes the how well our cells can be differentiated into terminal types. For these progenitors, we have protocols for differentiating into neurons, astrocytes, and oligodendrocytes.Neural Progenitors differentiated into Neurons and Stained with Tuj-1We also have Neural Progenitors from Alcohol and Opioid-Addicted Donors. (Source: Neuromics)

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Why Pig Organs Could Be the Future of Transplants

Thu, 15 Feb 2018 13:15:10 +0100

Making human tissue in a lab has always been more sci-fi than sci-fact, but powerful genetic technologies may change that soon. For the most part, the only way to replace diseased or failing hearts, lungs, kidneys and livers is with donor organs. Even then, many people struggle to find a good biological match with a donor, and 8,000 die each year in the U.S. while waiting for an organ. In one promising solution to the shortage, researchers have been putting a new DNA editing tool called CRISPR through rigorous tests in organ regeneration. Last August, a group of scientists led by George Church, professor of genetics at Harvard Medical School, generated more than a dozen pigs that were bred without certain viruses that had made many of their organs unusable for human transplant. Pig genomes...



Another Cancer Vaccine Shows Promise In Mice

Thu, 15 Feb 2018 12:02:35 +0100

THURSDAY, Feb. 15, 2018 -- In what researchers call a first step toward personalized vaccines for a multitude of cancers, a vaccine made from stem cells protected mice from tumors. The vaccine was composed of induced pluripotent stem cells (iPS... (Source: Drugs.com - Daily MedNews)



Stem Cell Vaccine Protects Mice From Cancer

Thu, 15 Feb 2018 12:00:00 +0100

Stem cells and cancer cells have enough molecular similarities that the former can be used to trigger immunity against the latter. (Source: The Scientist)



Building better tiny kidneys to test drugs and help people avoid dialysis

Thu, 15 Feb 2018 05:00:00 +0100

(University of Southern California) A free online kidney atlas built by USC researchers empowers stem cell scientists everywhere to generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies. The three-study series provides the first cellular and molecular characterization of how the human kidney develops in a mother's womb. The new, open-source data, available at www.gudmap.org, provides the first systematic, high-resolution atlas or databank for human kidney genesis. (Source: EurekAlert! - Medicine and Health)



Stem cell vaccine immunizes lab mice against multiple cancers

Thu, 15 Feb 2018 05:00:00 +0100

(Cell Press) Stanford University researchers report that injecting mice with inactivated induced pluripotent stem cells (iPSCs) launched a strong immune response against breast, lung, and skin cancers. The vaccine also prevented relapses in animals that had tumors removed. The work appears in the journal Cell Stem Cell on Feb. 15. (Source: EurekAlert! - Cancer)

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Induced pluripotent stem cells could serve as cancer vaccine, Stanford researchers say

Thu, 15 Feb 2018 05:00:00 +0100

(Stanford Medicine) Induced pluripotent stem cells, or iPS cells, are a keystone of regenerative medicine. Outside the body, they can be coaxed to become many different types of cells and tissues that can help repair damage due to trauma or disease. Now, a study in mice from the Stanford University School of Medicine suggests another use for iPS cells: training the immune system to attack or even prevent tumors. (Source: EurekAlert! - Cancer)



New stem-cell based stroke treatment repairs damaged brain tissue

Thu, 15 Feb 2018 05:00:00 +0100

(University of Georgia) A team of researchers at the University of Georgia's Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain's natural healing tendencies in animal models. (Source: EurekAlert! - Medicine and Health)



Two year old boy needs life-saving donors after rare blood disorder diagnosis

Thu, 15 Feb 2018 04:00:00 +0100

CANCER symptoms affects almost 360,000 new people in the UK every year. This International Childhood Cancer Day, blood cancer charity Anthony Nolan are raising awareness of rare disorders, as two-year old Jacob needs a stem cell donor for his aplastic anaemia condition. (Source: Daily Express - Health)



For one early adopter, CAR T therapy means 18 months cancer-free and counting

Wed, 14 Feb 2018 18:55:00 +0100

For as long as he can remember, Josh Feldman has eagerly embraced the latest technology.Decades ago, his family was the first one on the block with a VCR. Years later, when television went hi-def, he acquired a big-screen TV and signed up for HD service.So after he was diagnosed with lymphoma, it was only natural that Feldman was driven to join clinical trials for a promising new treatment. He would become one of the first UCLA Health patients to receive CAR T therapy. When nothing else worked, the treatment beat back cancer and filled his life with new hope.“Years ago, while doing my own reading after my diagnosis, I learned about CAR T,” he said. “I envisioned that it was going to be groundbreaking, and I wanted to be part of it.”CAR T, which stands for “chimeric antigen recept...



NIH solicits next-generation retina organoids in prize competition

Wed, 14 Feb 2018 05:00:00 +0100

(NIH/National Eye Institute) A competition for radical ideas in the fight against blindness will move to its next phase by challenging participants to build functioning human retina prototypes. The National Eye Institute (NEI) 3-D Retina Organoid Challenge (NEI 3-D ROC 2020) is a $1-million federal prize competition designed to generate lab-grown human retinas from stem cells. Organoids developed for the competition will mimic the structure, organization, and function of the human retina. (Source: EurekAlert! - Medicine and Health)

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A map app to track stem cells

Wed, 14 Feb 2018 05:00:00 +0100

(National Institute of Standards and Technology (NIST)) NIST's new system, the Web Image Processing Pipeline (WIPP), combines video footage and high-power computation to bring the world one step closer to evaluating, understanding and quantifying features of the populations living inside of a stem cell culture. WIPP could be used in the development of products for treating cancer and heart disease, or for use in regenerative medicine, among other things. (Source: EurekAlert! - Biology)



Could sugar chains be the answer to bone growth in osteoporosis?

Wed, 14 Feb 2018 05:00:00 +0100

(University of York) Scientists at the University of York have shown that altering the structure of sugar chains on the surface of stem cells could help promote bone growth in the body. (Source: EurekAlert! - Medicine and Health)



RenovaCare strikes back at shortseller Streetsweeper

Tue, 13 Feb 2018 21:01:07 +0100

RenovaCare late yesterday issued a response to shortseller Streetsweeper after the group released a scathing review of the company that was skeptical of it’s ability to hold its market valuation. The Gainesville, Fla.-based company strongly rejected the firm’s assessment, saying that Streetsweeper is known for spreading “short and distort” commentaries on companies it targets for short selling. “We will not be distracted by the irresponsible and nefarious actions of these short sellers and a handful of internet posters. We have an obligation to expose those who prey on our shareholders for short-term profits and attempt to damage the public trust. Meanwhile, our clinical and regulatory teams continue to make incredible strides, with our next major milestone b...



True to type: From human biopsy to complex gut physiology on a chip

Tue, 13 Feb 2018 05:00:00 +0100

(Wyss Institute for Biologically Inspired Engineering at Harvard) Published in Scientific Reports, Donald Ingber's team at the Wyss Institute leverages the organoid approach to isolate intestinal stem cells from human biopsies, but goes on to break up the organoids and culture the patient-specific cells within our Organ Chips where they spontaneously form intestinal villi oriented towards the channel lumen, and the epithelium in close apposition to human intestinal microvascular endothelium (Source: EurekAlert! - Infectious and Emerging Diseases)



Clues to aging found in stem cells' genomes

Tue, 13 Feb 2018 05:00:00 +0100

(Howard Hughes Medical Institute) In fruit flies, repeating genetic elements shrink with age, but then expand in future generations, a resurgence that may help explain how some cells stay immortal. (Source: EurekAlert! - Social and Behavioral Science)

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The unfolded protein response regulator ATF6 promotes mesodermal differentiation

Tue, 13 Feb 2018 00:00:00 +0100

ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Deletion of the isoform activating transcription factor 6α (ATF6α) and its paralog ATF6β results in embryonic lethality and notochord dysgenesis in nonhuman vertebrates, and loss-of-function mutations in ATF6α are associated with malformed neuroretina and congenital vision loss in humans. These phenotypes implicate an essential role for ATF6 during vertebrate development. We investigated this hypothesis using human stem cells undergoing differentiation into multipotent germ layers, nascent tissues, and organs. We artificially activated ATF6 in stem cells with a small-molecule ATF6 agonist and,...



Dentists may soon be able to regenerate from cavities

Mon, 12 Feb 2018 18:17:55 +0100

Teeth can already repair small problems on the outer layers of teeth. But two recent Kings College London studies show that treating the stem cells within the tooth pulp can trigger them to fix cavities (Source: the Mail online | Health)



Medical News Today: This protein fuels triple-negative breast cancer

Sat, 10 Feb 2018 08:00:00 +0100

Researchers report that they have identified a new stem cell pathway that drives the development of highly aggressive triple-negative breast cancer. (Source: Health News from Medical News Today)



Cincinnati Children ’s advances effort to grow organs for transplant

Fri, 09 Feb 2018 17:05:44 +0100

Scientists at Cincinnati Children ’s Hospital recently advanced efforts to grow human organs in a lab, which could lead to life-saving transplants for people who are seriously ill.  Researchers at the Avondale-based hospital’s Center for Stem Cell and Organoid Medicine have developed a new way to bioengineer human gut tissue a nd liver tissue, according to Cincinnati Children’s. The scientists devised a way to ensure genetic stability so organs are free from the risk of tumor growth as well… (Source: bizjournals.com Health Care:Biotechnology headlines)



Chinese researchers report first lung stem cell transplantation clinical trial

Fri, 09 Feb 2018 09:00:00 +0100

A research team from Tongji University in China have made a breakthrough in human lung regeneration technology. For the first time, researchers have regenerated patients' damaged lungs using autologous lung stem cell transplantation in a pilot clinical trial. The study can be found in the open access journal Protein & Cell which is published by Springer Nature. (Source: World Pharma News)

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Efficient technique discovered for isolating embryonic stem cells in cows

Fri, 09 Feb 2018 05:00:00 +0100

(University of California - Davis) Scientists at the University of California, Davis, have developed a highly efficient method of isolating embryonic stem cells in cows. Producing embryonic stem cells from large livestock species like cattle is important for genetic testing, genome engineering, and studying human disease. (Source: EurekAlert! - Medicine and Health)



Chinese researchers report first lung stem cell transplantation clinical trial

Fri, 09 Feb 2018 05:00:00 +0100

(Springer) A research team from Tongji University in China have made a breakthrough in human lung regeneration technology. For the first time, researchers have regenerated patients' damaged lungs using autologous lung stem cell transplantation in a pilot clinical trial. The study can be found in the open-access journal Protein& Cell which is published by Springer Nature. (Source: EurekAlert! - Biology)



Houston co. completes stem cell-for-cryptocurrency exchange

Thu, 08 Feb 2018 14:37:23 +0100

Meanwhile, the Houston company behind the technology announced a $10 million raise. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)



Stem cell research provides hope for tasmanian devils with a deadly, transmissible cancer

Thu, 08 Feb 2018 05:00:00 +0100

(Morris Animal Foundation) Using stem cell therapy, Morris Animal Foundation-funded researcher Dr. Deanne Whitworth and her colleagues at the University of Queensland, have taken the first step toward developing an effective treatment for devil facial tumor disease (DFTD), which is decimating Tasmanian devils in the wild. The team's findings were recently published in Stem Cells and Development. (Source: EurekAlert! - Biology)



Scientists develop a 'third eye' to examine stem cells

Thu, 08 Feb 2018 05:00:00 +0100

(Moscow Institute of Physics and Technology) The researchers employed the triple labeling technique to analyze stem cells in the brain, the intestine, and testis, using additional tricks to effectively expand the technique to quadruple labeling of dividing stem cells.The new method will increase the accuracy and speed of stem cell division analysis and reveal new populations of stem cells. (Source: EurekAlert! - Medicine and Health)

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Researchers uncover how cancer stem cells drive triple-negative breast cancer

Thu, 08 Feb 2018 05:00:00 +0100

(Cleveland Clinic) Cleveland Clinic researchers have published findings in Nature Communications on a new stem cell pathway that allows a highly aggressive form of breast cancer -- triple-negative breast cancer -- to thrive. (Source: EurekAlert! - Cancer)



Revising concepts about adult stem cells

Thu, 08 Feb 2018 00:00:00 +0100

(Source: ScienceNOW)



Why More Scientists Are Running For Office in 2018

Wed, 07 Feb 2018 17:48:07 +0100

Getting scientists to become more politically involved has been an ongoing movement this year, with groups like the American Association for the Advancement of Science and American Chemical Society encouraging scientists to voice their opinions and even join protests, like the March for Science in April 2017. Now, hundreds of scientists and STEM professionals are running for public office in 2018, for everything from Senate seats to a spot on the local school board. “I’m not a politician, I’m a doctor,” reads the first line of Dr. Jason Westin‘s bio on his campaign website for Texas’s 7th congressional district seat. Westin, a cancer doctor based in Houston who is challenging Republican John Abney Culberson, decided to run for office after the results of...



Culturing Cells in Defined 3-D Structures

Wed, 07 Feb 2018 14:24:00 +0100

In this study, the authors present in-air microfluidics (IAMF), a new chip-free platform technology that enables in-flight (that is, on-the-fly) formation of droplets, fibers, and particles and their one-step deposition into 3D constructs with a modular internal architecture.Figure: Concept of IAMF and guide to the article. (A) Chip-based microfluidics enables in-line control over droplets and particles, making it a versatile platform technology. A chip design where droplets (blue) are transported by a coflow (pink) is shown. (B) IAMF maintains the in-line control of chip-based microfluidics but relies on jet ejection and coalescence into air. Therefore, a wide range of droplets and particles can be produced at flow rates typically two orders of magnitude higher than with chip-based microf...

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Texas A & M, Houston ’s Celltex team up to research Alzheimer's therapies

Tue, 06 Feb 2018 18:07:03 +0100

Houston-based Celltex Therapeutics Corp. and Texas A&M University Health Science Center College of Medicine Institute for Regenerative Medicine have entered into a multiyear agreement for research into potential Alzheimer's therapies.   The research will utilize Celltex's proprietary stem cell process and will involve anti-inflammatory exosomes derived from autologous mesenchymal stem cells (MSC), according to a press release. Exosomes are small vesicles — fluid- or air-filled cavities or sacs… (Source: bizjournals.com Health Care News Headlines)



Are anti-ageing stem cell jabs really safe?

Tue, 06 Feb 2018 01:27:19 +0100

The 'precursor' cells are increasingly being used in the beauty industry to slow the signs of ageing, despite warnings that they could develop into rogue cells which could even cause cancer. (Source: the Mail online | Health)



Researchers Show Stem Cell Therapy May Reverse Disability in Multiple...

Tue, 06 Feb 2018 00:00:00 +0100

Tisch MS Research Center of New York Publishes Promising Results in Phase I Stem Cell Trial for MS(PRWeb February 06, 2018)Read the full story at http://www.prweb.com/releases/2018/02/prweb15178748.htm (Source: PRWeb: Medical Pharmaceuticals)



BrainStorm Cell Therapeutics Appoints Senior Kite Executive, Anthony Polverino, Ph.D., to Board of Directors

Mon, 05 Feb 2018 12:36:21 +0100

HACKENSACK, N.J. and PETACH TIKVAH, Israel, Feb. 5, 2018 -- (Healthcare Sales & Marketing Network) -- BrainStorm Cell Therapeutics Inc. (NASDAQ: BCLI), a leading developer of adult stem cell therapeutics for neurodegenerative diseases, announced today the... Biopharmaceuticals, Neurology, Personnel BrainStorm Cell Therapeutics, NurOwn , stem cell, amyotrophic lateral sclerosis (Source: HSMN NewsFeed)



The potential of stem cells in treatment of traumatic brain injury - Weston NM, Sun D.

Mon, 05 Feb 2018 09:42:49 +0100

PURPOSE OF REVIEW: Traumatic brain injury (TBI) is a global public health concern, with limited treatment options available. Despite improving survival rate after TBI, treatment is lacking for brain functional recovery and structural repair in clinic. Rece... (Source: SafetyLit)

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Scientists target glioma cancer stem cells, which could improve patient survival

Mon, 05 Feb 2018 05:00:00 +0100

(Dartmouth-Hitchcock Medical Center) Brain tumors are responsible for 25 percent of cancer-related deaths in children and young adults. Despite initial response to treatment, most aggressive brain tumors eventually recur and are ultimately incurable. Multiple studies suggest that cancer stem cells within these tumors resist therapy and are responsible for tumor recurrences. Researchers at Dartmouth's Norris Cotton Cancer Center have devised a strategy to treat these tumors by identifying a secretion-mediated pathway that's essential for maintaining glioma cancer stem cells. (Source: EurekAlert! - Medicine and Health)



Zika brain damage may go undetected in pregnancy

Mon, 05 Feb 2018 05:00:00 +0100

(University of Washington Health Sciences/UW Medicine) Zika virus may cause significant damage to the fetal brain even when the baby's head size is normal, according to a primate study. The damage can be difficult to detect even with sophisticated brain scans. It may also occur from infections during childhood and adolescence. Hard hit are brain regions that generate new brain cells. Fetal brain structures that may be injured include those where neural stem cells play a role in learning and memory. (Source: EurekAlert! - Infectious and Emerging Diseases)



CHLA joins national consortium to study use of stem cells to treat a rare cardiac defect

Mon, 05 Feb 2018 05:00:00 +0100

(Children's Hospital Los Angeles) Children's Hospital Los Angeles has announced participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart. The HLHS Consortium, launched at the Mayo Clinic in Minnesota in 2017, involves up to four regional centers. CHLA, the only West Coast member, makes the initiative bicoastal. (Source: EurekAlert! - Medicine and Health)



Ribosomes found to induce somatic cell pluripotency

Sun, 04 Feb 2018 05:00:00 +0100

(Kumamoto University) In 2012, a Japanese research group discovered that human skin cells acquire pluripotency when introduced to lactic acid bacteria (Lactobacillus acidophilus). Now, the same group of researchers have found that the cause of somatic cell conversion into pluripotent stem cells is the ribosome, a protein synthesizing cellular organelle. (Source: EurekAlert! - Cancer)



Stem Cell Therapy for Concussions: Is It for Real?

Fri, 02 Feb 2018 18:00:00 +0100

(MedPage Today) --'We haven't even begun to study this'(Source: MedPage Today Public Health)

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Anika collabs to develop injectable stem cell therapy for osteoarthritis

Fri, 02 Feb 2018 13:32:59 +0100

Anika Therapeutics (NSDQ:ANIK) has inked an agreement with the Institute of Integrative Biology at the University of Liverpool to develop an injectable mesenchymal stem cell therapy to treat osteoarthritis. As a result of the three-year research collaboration, the group hopes to have a lead candidate that it can take into clinical trials. Get the full story at our sister site, Drug Delivery Business News. The post Anika collabs to develop injectable stem cell therapy for osteoarthritis appeared first on MassDevice. (Source: Mass Device)



Genetic factors that make babies susceptible to complications from Zika are identified

Fri, 02 Feb 2018 05:00:00 +0100

(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Study of twins exposed to Zika virus during pregnancy was conducted at the University of S ã o Paulo's Human Genome& Stem Cell Research Centre in Brazil. Results are published in Nature Communications (Source: EurekAlert! - Medicine and Health)



New mouse model makes stem cells light up green

Thu, 01 Feb 2018 05:00:00 +0100

(University of Bonn) Multipotent stromal cells have long been a hot topic in medical research. Scientists at the University of Bonn have now found a way to specifically mark these stem cells. This makes it possible to analyze their distribution pattern and their function in living organisms. The study, which included researchers from Oxford University, Tsukuba University and the Karolinska Institute Stockholm, is now being published in the journal " Cell Stem Cell " . (Source: EurekAlert! - Medicine and Health)



Haematopoietic stem cell transplantation cost effective

Thu, 01 Feb 2018 00:00:00 +0100

(Source: PharmacoEconomics and Outcomes News)



NIDCR Science News

Wed, 31 Jan 2018 20:00:58 +0100

Having trouble viewing this email? View it as a Web page.   Pioneering Gene Therapy for Dry MouthOngoing clinical trial explores saliva-restoring gene transfer NIDCR • January 18, 2018​​   Stem Cell Study of Jaw Development Could Offer Insight into Craniofacial FlawsUniversity of Southern California • January 18, 2018 ​Researchers Get First Complete Look at Protein Behind Sense of TouchThe Scripps Research Institute • December 20, 2017 STAY CONNECTED     (Source: NIDCR Science News)

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RenovaCare touts data from 44-patient SkinGun burn treatment retrospective analysis

Tue, 30 Jan 2018 21:52:24 +0100

RenovaCare today released results from a retrospective analysis of 44 patients with severe second-degree wide-area burn injuries who were treated with the technology underlying the company’s SkinGun and CellMist system. Results from the analysis were published in the peer-reviewed journal Burns, the company said. “Treated patients presented with a variety of burn wound etiologies and a wide range of TBSA (Total Burn Surface Area). Overall clinical results were very satisfying,” study authors wrote in a press release. The 44 patients in the analysis were treated through a method which involved isolating and spraying the patients’ skin stem cells onto burn wounds, which RenovaCare said uses technology its SkinGun and CellMist system are based off of. Patients in the ...



UCLA scientists use stem cells to study genetics of germ cell tumors

Mon, 29 Jan 2018 23:11:06 +0100

UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells — the cells that develop into sperm and eggs. The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer.Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer.The study, published in Stem Cell Research, was led by Amander Clark, a UCLA professor of molecular cell and developmental biology and a member of theEli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.Germ cell tumors most often develop during embryonic development, in the ...



Scientists Discover a Bone-Deep Risk for Heart Disease

Mon, 29 Jan 2018 15:50:58 +0100

Few doctors, and even fewer patients, have heard of C.H.I.P. But it is emerging as a major cause of heart attacks and stroke, as deadly as high blood pressure or cholesterol. (Source: NYT Health)



Morris Animal Foundation-funded study points way to improved stem cell therapies

Mon, 29 Jan 2018 05:00:00 +0100

(Morris Animal Foundation) In a study using equine mesenchymal stem cells, Morris Animal Foundation-funded researchers from Cornell University and North Carolina State University found that stem cell function can be enhanced through manipulation of their culture environment, and that 'priming' prior to patient administration could optimize their therapeutic potential. The research team published their results in Veterinary Immunology and Immunopathology. (Source: EurekAlert! - Medicine and Health)



Medical News Today: How does high cholesterol cause cancer? Study sheds light

Fri, 26 Jan 2018 15:00:00 +0100

Researchers have discovered a cell mechanism in which cholesterol influences the proliferation of stem cells and the growth of intestinal tumors in mice. (Source: Health News from Medical News Today)

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From stem cells to a functional heart: The role of the Mesp1 gene

Fri, 26 Jan 2018 05:00:00 +0100

(Universit é libre de Bruxelles) Researchers at the Universit é libre de Bruxelles and University of Cambridge identified the role of key gene Mesp1 in the earliest step of cardiovascular lineage segregation. This discovery may help to better understand congenital heart defects. (Source: EurekAlert! - Medicine and Health)



Gene therapy using CAR T cells could provide long-term protection against HIV

Thu, 25 Jan 2018 20:34:45 +0100

FINDINGSA UCLA-led research team has created blood-forming stem cells that can carry a gene that allows the body to produce cells that can detect and destroy HIV-infected cells. The blood-forming cells, called hematopoietic stem and progenitor cells, or HSPCs, have been engineered to carry chimeric antigen receptor, or CAR, genes that allows the production of immune cells that target cells infected with HIV.After being transplanted into the body, the engineered cells formed immune cells that not only destroyed the infected cells, but also lived for more than two years. This suggests that they have the potential to give people long-term immunity from HIV, the virus that causes AIDS.BACKGROUNDAntiviral drugs are a key element in treating HIV, because they can suppress the virus in the body t...



UCLA study could explain link between high-cholesterol diet and colon cancer

Thu, 25 Jan 2018 17:00:00 +0100

New UCLA research could help explain the link between a high-cholesterol diet and an elevated risk for colon cancer.In a study of mice, scientists from theDavid Geffen School of Medicine at UCLA discovered that boosting the animals ’ cholesterol levels spurred intestinal stem cells to divide more quickly, enabling tumors to form significantly faster. Published online in Cell Stem Cell, the study identifies a new target for colon cancer treatment.“We were excited to find that cholesterol influences the growth of stem cells in the intestines, which in turn accelerates the rate of tumor formation by more than 100-fold,” said Dr. Peter Tontonoz, the medical school ’s Frances and Albert Piansky Professor of Pathology and Laboratory Medicine. “While the connection between dietary cho...



Stem Cells Made by Modifying the Epigenome with CRISPR

Thu, 25 Jan 2018 15:00:00 +0100

Researchers use the technique to turn on Oct4 or Sox2 in mouse embryonic fibroblasts and convert them into pluripotent cells. (Source: The Scientist)



Will State Voters Continue To Pour Money Into Stem Cell Research?

Thu, 25 Jan 2018 10:00:16 +0100

California alone has spent billions in state funds over the last 14 years to support stem cell research. Scientists want another round of cash. So, what exactly did voters get for their money so far?(Image credit: Courtesy of Alysia Padilla-Vaccaro ) (Source: NPR Health and Science)

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UCLA study could explain link between high-cholesterol diet and colon cancer

Thu, 25 Jan 2018 05:00:00 +0100

(University of California - Los Angeles Health Sciences) UCLA scientists discovered that boosting mice's cholesterol levels spurred intestinal stem cells to divide more quickly, enabling tumors to form 100 times faster. The study identifies a molecular pathway that could serve as a new drug target for colon cancer treatment. (Source: EurekAlert! - Cancer)



Letting silenced genes speak

Thu, 25 Jan 2018 05:00:00 +0100

(University of Connecticut) Stem cell researchers at UConn Health have reversed Prader-Willi syndrome in brain cells growing in the lab. The discovery provides clues that could lead to a treatment for Prader-Willi, a genetic disorder that silences genes necessary for normal brain function. Prader-Willi occurs in about one out of every 15,000 births, and is the most common genetic cause of life-threatening childhood obesity. (Source: EurekAlert! - Medicine and Health)



Spermidine in health and disease

Thu, 25 Jan 2018 00:00:00 +0100

Interventions that delay aging and protect from age-associated disease are slowly approaching clinical implementation. Such interventions include caloric restriction mimetics, which are defined as agents that mimic the beneficial effects of dietary restriction while limiting its detrimental effects. One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticancer immunosurveillance in rodent models. Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortality in human epidemiological studies. Spermidine preserves mitochondrial function, exhibits anti-inflammatory properties, and prevents stem cell senescence. Mechanistically, it shares the molecular pathways engaged by other calo...



Targeting bladder cancer's Achilles heel: stem cells

Wed, 24 Jan 2018 05:00:00 +0100

(Johns Hopkins Medicine) Two different proteins work separately as well as synergistically to feed a small pool of stem cells that help bladder cancer resist chemotherapy, research led by a Johns Hopkins Kimmel Cancer Center scientist suggests. The finding, published online in Cancer Research, could lead to new targets to fight this deadly disease and potentially other cancers as well. (Source: EurekAlert! - Cancer)



Discovery may advance neural stem cell treatments for brain disorders

Wed, 24 Jan 2018 05:00:00 +0100

(Sanford-Burnham Prebys Medical Discovery Institute) New research from SBP reveals a novel gene regulatory system that may advance stem cell therapies and gene-targeting treatments for neurological diseases such as Alzheimer's disease, Parkinson's disease, and mental health disorders that affect cognitive abilities. (Source: EurekAlert! - Cancer)

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Stem cell transplant helps people with severe scleroderma

Tue, 23 Jan 2018 15:35:57 +0100

A study of people with severe scleroderma found that a new approach using stem cell transplants provides a better outcome than an immune-suppressing drug. (Source: NIH Research Matters from the National Institutes of Health (NIH))



Surgeon creates a  bionic vagina from pig intestine

Mon, 22 Jan 2018 16:25:57 +0100

The artificial organ was developed also using a patient's stem cells. The project is led by Professor Alexander Seifalian from  London-based NanoRegMed, who made the first synthetic trachea. (Source: the Mail online | Health)



Astellas and Vical Announce Top-Line Results for Phase 3 Trial of Cytomegalovirus Vaccine ASP0113 in Hematopoietic Stem Cell Transplant Recipients

Mon, 22 Jan 2018 12:33:08 +0100

TOKYO and SAN DIEGO, Jan. 22, 2018 -- (Healthcare Sales & Marketing Network) -- Astellas Pharma Inc. (TSE: 4503, President and CEO: Yoshihiko Hatanaka, "Astellas") and Vical Incorporated (NASDAQ: VICL) announced today that ASP0113, an investigat... Biopharmaceuticals Astellas Pharma, Vical , cytomegalovirus (Source: HSMN NewsFeed)



TSRI researchers identify gene responsible for mesenchymal stem cells' stem-ness'

Mon, 22 Jan 2018 05:00:00 +0100

(Scripps Research Institute) Researchers at The Scripps Research Institute recently published a study in the journal Cell Death and Differentiation identifying factors crucial to mesenchymal stem cell differentiation, providing insight into how these cells should be studied for clinical purposes. (Source: EurekAlert! - Cancer)



Not just a stem cell marker

Mon, 22 Jan 2018 05:00:00 +0100

(King Abdullah University of Science& Technology (KAUST)) The protein CD34 is predominantly regarded as a marker of blood-forming stem cells but it helps with migration to the bone marrow too. (Source: EurekAlert! - Medicine and Health)

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Can stem cell exosome therapy reduce fatal heart disease in diabetes?

Fri, 19 Jan 2018 05:00:00 +0100

(University of Alabama at Birmingham) Removal of dead or dying heart muscle cells after a heart attack is crucial. Researchers have preliminary data that diabetes impairs this removal, and this impairment may be the reason diabetes increases the risk for cardiovascular disease, including heart failure. With aid of a new grant, investigators will study whether mesenchymal stem cells or their exosomes can boost dead cell removal and reduce damaging inflammation after heart attacks in animal models of diabetes. (Source: EurekAlert! - Medicine and Health)



Hedgehog signaling proteins keep cancer stem cells alive

Fri, 19 Jan 2018 05:00:00 +0100

(Charit é - Universit ä tsmedizin Berlin) Researchers from Charit é - Universit ä tsmedizin Berlin have discovered that the survival of cancer stem cells is dependent on the 'Hedgehog signaling pathway.' Targeting this pathway had previously shown no effect on the growth of colorectal cancer. Now, Charit é scientists have demonstrated that using different drugs to target a specific aspect of the pathway may yield better treatment outcomes for patients. Results from this research have been published in the journal Cell Reports. (Source: EurekAlert! - Cancer)



Researchers create first stem cells using CRISPR genome activation

Thu, 18 Jan 2018 05:00:00 +0100

(Gladstone Institutes) In a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology. The innovative approach offers a potentially simpler technique to produce the valuable cell type and provides important insights into the cellular reprogramming process. (Source: EurekAlert! - Biology)



USC stem cell scientists chew on the mysteries of jaw development

Thu, 18 Jan 2018 05:00:00 +0100

(University of Southern California - Health Sciences) Scientists in the USC Stem Cell laboratory of Gage Crump have revealed how key genes guide the development of the jaw in zebrafish. These findings may offer clues for understanding craniofacial anomalies in human patients, who sometimes carry a mutation in equivalent genes. (Source: EurekAlert! - Biology)



Vitamin deficiency we are all born with

Wed, 17 Jan 2018 19:09:27 +0100

I’ve admired Linus Pauling for years. In 1976, the Nobel Prize-winning chemist gave mega doses of vitamin C to 100 “untreatable” cancer patients. He then compared these so-called terminal patients to patients with the same kind of cancer who didn’t get vitamin C. The patients who received the traditional cancer treatment lived for an average of six months. Pauling’s patients lived — on average — for six years. You’d think that the medical community would have heralded Pauling’s research as a huge breakthrough in cancer treatment. But they didn’t. And they still don’t. Despite groundbreaking research like this, traditional doctors still dismiss vitamin C as “unnecessary” and “a waste of money.” And that’s a big mistake because we were all born with a severe...

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Children's awarded $2.6 million to study stem cells for CHD-related neurological complications

Wed, 17 Jan 2018 05:00:00 +0100

(Children's National Health System) The National Institutes of Health (NIH) awarded researchers at Children's National Health System $2.6 million to expand their studies into whether human stem cells could someday treat and even reverse neurological damage in infants born with congenital heart disease (CHD). (Source: EurekAlert! - Medicine and Health)



Timothy Ray Brown, cured of HIV, rallies public to support research funding

Wed, 17 Jan 2018 05:00:00 +0100

(Mary Ann Liebert, Inc./Genetic Engineering News) In the 10th anniversary year since a bone marrow stem cell transplant cured Timothy Ray Brown of his HIV infection, despite disappointment over decreasing public desire to find a cure for HIV, Timothy Ray Brown remains optimistic that the scientific and medical communities can and will achieve this if properly funded. (Source: EurekAlert! - Medicine and Health)



Children's awarded $2.6M to study stem cells for CHD-related neurological complications

Wed, 17 Jan 2018 05:00:00 +0100

(Children's National Health System) The National Institutes of Health (NIH) awarded researchers at Children's National Health System $2.6 million to expand their studies into whether human stem cells could someday treat and even reverse neurological damage in infants born with congenital heart disease (CHD). (Source: EurekAlert! - Medicine and Health)



Stem Cell Gene Therapy Might Guard Against HIV Stem Cell Gene Therapy Might Guard Against HIV

Tue, 16 Jan 2018 21:01:50 +0100

Research in monkeys suggests that hematopoietic stem/progenitor Cclls (HSPCs) in concert with chimeric antigen receptor (CAR) T-cells could provide long-lasting protection against HIV.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)



New molecular probes to allow non-destructive analysis of bioengineered cartilage

Tue, 16 Jan 2018 05:00:00 +0100

(Mary Ann Liebert, Inc./Genetic Engineering News) A new study describes novel probes that enable non-invasive, non-destructive, direct monitoring of the differentiation of mesenchymal stem cells (MSCs) in real-time during the formation of engineered cartilage to replace damaged or diseased tissue. (Source: EurekAlert! - Biology)

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The HLF gene protects blood stem cells by maintaining them in a resting state

Tue, 16 Jan 2018 05:00:00 +0100

(Lund University) The HLF gene is necessary for maintaining our blood stem cells in a resting state, which is crucial for ensuring normal blood production. This has been shown by a new research study from Lund University in Sweden published in Cell Reports. (Source: EurekAlert! - Medicine and Health)



Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome

Tue, 16 Jan 2018 00:00:00 +0100

We examined functional maturation of the excitatory transmission system in FXS by investigating the response of FXS patient–derived neural progenitor cells to the glutamate analog (AMPA). Neural progenitors derived from induced pluripotent stem cell (iPSC) lines generated from boys with FXS had augmented intracellular Ca2+ responses to AMPA and kainate that were mediated by Ca2+-permeable AMPA receptors (CP-AMPARs) lacking the GluA2 subunit. Together with the enhanced differentiation of glutamate-responsive cells, the proportion of CP-AMPAR and N-methyl-d-aspartate (NMDA) receptor–coexpressing cells was increased in human FXS progenitors. Differentiation of cells lacking GluA2 was also increased and paralleled the increased inward rectification in neural progenitors derived fro...



USRM Reaches Key Sales Milestone of Proprietary Adipocell(TM) Product

Mon, 15 Jan 2018 13:18:28 +0100

Company Poised to Be Industry Leader in Autologous Adipose Stem Cell Treatments SUNRISE, Fla., Jan. 15, 2018 -- (Healthcare Sales & Marketing Network) -- U.S. Stem Cell, Inc. (OTC: USRM), a leader in the development of proprietary, physician-based stem... Regenerative Medicine U.S. Stem Cell, Adipocell, stem cell (Source: HSMN NewsFeed)



UCLA scientists make cells that enable the sense of touch

Fri, 12 Jan 2018 00:02:46 +0100

Researchers at the  Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons — the cells that give us our sense of touch. The new protocol could be a step toward stem cell–based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body.The study, which was led by Samantha Butler, a UCLA associate professor of neurobiology and member of the Broad Stem Cell Research Center, was published today in the journal Stem Cell Reports.Sensory interneurons, a class of neurons in the spinal cord, are responsible for relaying information from throughout the body to the central nervous system, which enables the sense of touch. The lack of a sense of touch...



Upfront Stem Cell Transplant Remains Standard of Care for Newly Diagnosed Multiple Myeloma Upfront Stem Cell Transplant Remains Standard of Care for Newly Diagnosed Multiple Myeloma

Thu, 11 Jan 2018 21:50:54 +0100

Reuters Health Information (Source: Medscape Allergy Headlines)

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NIDCR Autotherapies Symposium | Thurs., Jan. 25, 8:00 a.m.-12:00 p.m.

Thu, 11 Jan 2018 20:05:21 +0100

Having trouble viewing this email? View it as a Web page.   NIDCR invites you to a scientific symposium: "Autotherapies: Enhancing Our Innate Healing Capacity"  Thursday, January 25, 8:00 am-12:00 pm Lipsett Amphitheater in the NIH Clinical Center (Building 10)NIH Campus, Bethesda, Md. Autotherapies are treatments based on the body's natural ability to heal and protect itself. For example, immunotherapy harnesses the body’s immune cells to fight cancer and is now in clinical use. In the dental, oral, and craniofacial region, autotherapies could be used to selectively signal the body to repair and regenerate tissue, trigger immune responses, and re...



Researchers map genetic ‘switches’ behind human brain evolution

Thu, 11 Jan 2018 14:02:50 +0100

FINDINGSUCLA researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains and, in some cases, set the stage for several brain disorders that appear later in life.BACKGROUNDThe human brain differs from that of mice and monkeys because of its large cerebral cortex. The organ ’s most highly developed part, the cerebral cortex is responsible for thinking, perceiving and sophisticated communication. Scientists are just beginning to understand the molecular and cellular mechanisms that drive the growth of the human brain and the major role they play in human cognition.Brain development is guided by the...



Alcohol may be 'very damaging' to people with 'Asian glow'

Thu, 11 Jan 2018 10:00:00 +0100

Why does drinking alcohol boost your risk of cancer? By damaging the DNA in your stem cells, a new study suggests. And if your face flushes red after you sip half a bottle of beer, like many Asians, you could be getting way more DNA damage than other people. (Source: CBC | Health)



UCLA scientists make cells that enable the sense of touch

Thu, 11 Jan 2018 05:00:00 +0100

(University of California - Los Angeles Health Sciences) Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons -- the cells that give us our sense of touch. The new protocol could be a step toward stem cell-based therapies to restore sensation in paralyzed people who have lost feeling in parts of their body. (Source: EurekAlert! - Medicine and Health)



Long-lasting adaptations of the innate immune system through the bone marrow

Thu, 11 Jan 2018 05:00:00 +0100

(Radboud University Nijmegen) The immune system not only detects and destroys pathogens such as microbes but also plays a role in the onset of diseases such as arteriosclerosis. Scientists from Radboud university medical center, Bonn, Dresden and Pennsylvania, studied a new mechanism that regulates the immune system's functioning. They discovered that cholesterol inhibitors may prevent infections, that a high-fat Western diet can have a long-lasting effect on our immunity and that even our stem cells can be disrupted. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Researchers map out genetic 'switches' behind human brain evolution

Thu, 11 Jan 2018 05:00:00 +0100

(University of California - Los Angeles) UCLA researchers have developed the first map of gene regulation in human neurogenesis, the process by which neural stem cells turn into brain cells and the cerebral cortex expands in size. The scientists identified factors that govern the growth of our brains and, in some cases, set the stage for several brain disorders that appear later in life. (Source: EurekAlert! - Social and Behavioral Science)



Stem cell-rich cord blood donations could increase by 'nudging' parents, study suggests

Thu, 11 Jan 2018 05:00:00 +0100

(University of Toronto, Rotman School of Management) A two-year study of expectant mothers in Milan, Italy, has found that cord blood donations increased significantly when parents received information about the procedure and " prompts " to indicate their interest in donating at both early and late stages of their pregnancies. (Source: EurekAlert! - Social and Behavioral Science)



Gene therapy comes of age

Thu, 11 Jan 2018 00:00:00 +0100

After almost 30 years of promise tempered by setbacks, gene therapies are rapidly becoming a critical component of the therapeutic armamentarium for a variety of inherited and acquired human diseases. Gene therapies for inherited immune disorders, hemophilia, eye and neurodegenerative disorders, and lymphoid cancers recently progressed to approved drug status in the United States and Europe, or are anticipated to receive approval in the near future. In this Review, we discuss milestones in the development of gene therapies, focusing on direct in vivo administration of viral vectors and adoptive transfer of genetically engineered T cells or hematopoietic stem cells. We also discuss emerging genome editing technologies that should further advance the scope and efficacy of gene therapy approa...



The epigenetic control of stemness in CD8+ T cell fate commitment

Thu, 11 Jan 2018 00:00:00 +0100

After priming, naïve CD8+ T lymphocytes establish specific heritable transcription programs that define progression to long-lasting memory cells or to short-lived effector cells. Although lineage specification is critical for protection, it remains unclear how chromatin dynamics contributes to the control of gene expression programs. We explored the role of gene silencing by the histone methyltransferase Suv39h1. In murine CD8+ T cells activated after Listeria monocytogenes infection, Suv39h1-dependent trimethylation of histone H3 lysine 9 controls the expression of a set of stem cell–related memory genes. Single-cell RNA sequencing revealed a defect in silencing of stem/memory genes selectively in Suv39h1-defective T cell effectors. As a result, Suv39h1-defective CD8+ T cell...



Stem Cell Therapy Helps Resolve Complex Perianal Fistulas in Crohn's Disease Stem Cell Therapy Helps Resolve Complex Perianal Fistulas in Crohn's Disease

Wed, 10 Jan 2018 19:06:50 +0100

Local administration of allogeneic expanded adipose-derived stem cells (Cx601) improves resolution of complex perianal fistulas in patients with Crohn's disease, according to results from the ADMIRE CD trial.Reuters Health Information (Source: Medscape Medical News Headlines)

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