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MedWorm: Chronic Fatigue Syndrome



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Chronic Fatigue Syndrome category.



Last Build Date: Tue, 22 Mar 2016 08:25:27 +0100

 



Occupational exposure and health problems among Polish denturists: a population‐based study in Łódź province

Tue, 22 Mar 2016 06:26:00 +0100

ConclusionsAnalyses of denturists’ occupational exposure in the Łódź province and epidemiological estimates of the health effects suggest the need for preventive measures. (Source: International Dental Journal)

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Chronic unexplained fatigue.

Fri, 18 Mar 2016 04:28:02 +0100

Authors: White PD Abstract Fatigue is a common symptom in the community and the commonest associations are with stress or mood disturbance. One in a hundred people complain of unexplained and prolonged fatigue, with half that number meeting the strictest criteria for the chronic fatigue syndrome (CFS). Discrete fatigue syndromes have been described, particularly after Epstein Barr virus infection. The majority of patients with CFS have a syndrome similar to the ICD-10 definition of neurasthenia. Mood and somatoform disorders are common comorbid or differential diagnoses. The prognosis is poor, particularly in patients attending hospitals and those with comorbid psychiatric disorders. The aetiology of both CFS and chronic unexplained fatigue are essentially unknown, perhaps reflecti...



Child abuse and physical health in adulthood.

Fri, 18 Mar 2016 00:03:01 +0100

Authors: Afifi TO, MacMillan HL, Boyle M, Cheung K, Taillieu T, Turner S, Sareen J Abstract BACKGROUND: A large literature exists on the association between child abuse and mental health, but less is known about associations with physical health. The study objective was to determine if several types of child abuse were related to an increased likelihood of negative physical health outcomes in a nationally representative sample of Canadian adults. DATA AND METHODS: Data are from the 2012 Canadian Community Health Survey-Mental Health (n = 23,395). The study sample was representative of the Canadian population aged 18 or older. Child physical abuse, sexual abuse, and exposure to intimate partner violence were assessed in relation to self-perceived general health and 13 self-repor...



NIH Gears Up for First-Ever Chronic Fatigue Study

Thu, 17 Mar 2016 16:30:00 +0100

(MedPage Today) -- Patients' advocates share concerns about trial protocol, bias (Source: MedPage Today Psychiatry)



Methods of applying the 1994 case definition of chronic fatigue syndrome – impact on classification and observed illness characteristics

Sat, 12 Mar 2016 00:00:00 +0100

Multiple case definitions are in use to identify chronic fatigue syndrome (CFS). Even when using the same definition, methods used to apply definitional criteria may affect results. The Centers for Disease Con... (Source: Population Health Metrics)



Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives.

Fri, 11 Mar 2016 13:16:02 +0100

This article reviews the efficacy and safety of FMT used in treating a variety of diseases, methodology, criteria for donor selection and screening, and various concerns regarding FMT. PMID: 26956193 [PubMed - as supplied by publisher] (Source: Clinical Endoscopy)

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Sony musician Ren Gill to give up career amid Lyme disease battle

Thu, 10 Mar 2016 14:31:20 +0100

Ren Gill, 25, from Brighton, was first diagnosed with depression and bipolar disorder, then chronic fatigue syndrome but was finally diagnosed with Lyme disease at a clinic in Brussels. (Source: the Mail online | Health)



Illness progression in chronic fatigue syndrome: a shifting immune baseline

Thu, 10 Mar 2016 00:00:00 +0100

Validation of biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) across data sets has proven disappointing. As immune signature may be affected by many factors, our objective was to exp... (Source: BMC Immunology)



Fatigue and other adverse effects in men treated by pelvic radiation and long-term androgen deprivation for locally advanced prostate cancer.

Wed, 09 Mar 2016 00:00:00 +0100

Conclusions Fatigue and impaired QoL in patients considered to curative irradiation with long-term AD should be addressed when counseling men to combined treatment. PMID: 26959297 [PubMed - as supplied by publisher] (Source: Acta Oncologica)



The aetiopathogenesis of fatigue: unpredictable, complex and persistent

Tue, 08 Mar 2016 00:00:00 +0100

Background Chronic fatigue syndrome is a common condition characterized by severe fatigue with post-exertional malaise, impaired cognitive ability, poor sleep quality, muscle pain, multi-joint pain, tender lymph nodes, sore throat or headache. Its defining symptom, fatigue is common to several diseases. Areas of agreement Research has established a broad picture of impairment across autonomic, endocrine and inflammatory systems though progress seems to have reached an impasse. Areas of controversy The absence of a clear consensus view of the pathophysiology of fatigue suggests the need to switch from a focus on abnormalities in one system to an experimental and clinical approach which integrates findings across multiple systems and their constituent parts and to consider multiple environ...



Suicide risk in people with chronic fatigue syndrome - Kapur N, Webb R.

Thu, 03 Mar 2016 20:19:31 +0100

[Abstract unavailable] Language: en... (Source: SafetyLit)

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Stars in Their Eyes winner Faye Dempsey on being struck with chronic fatigue syndrome

Tue, 01 Mar 2016 11:46:52 +0100

Faye Dempsey, 33, from Wirral, won the television talent contest in 1997, performing as Olivia Newton-John. But now, debilitating illnesses mean she struggles to go outside. (Source: the Mail online | Health)



Chronic Pelvic Pain in Women.

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Speer LM, Mushkbar S, Erbele T Abstract Chronic pelvic pain in women is defined as persistent, noncyclic pain perceived to be in structures related to the pelvis and lasting more than six months. Often no specific etiology can be identified, and it can be conceptualized as a chronic regional pain syndrome or functional somatic pain syndrome. It is typically associated with other functional somatic pain syndromes (e.g., irritable bowel syndrome, nonspecific chronic fatigue syndrome) and mental health disorders (e.g., posttraumatic stress disorder, depression). Diagnosis is based on findings from the history and physical examination. Pelvic ultrasonography is indicated to rule out anatomic abnormalities. Referral for diagnostic evaluation of endometriosis by laparoscopy is u...



Nutritional advice for community patients: insights from a panel discussion.

Tue, 01 Mar 2016 00:00:00 +0100

This article describes the conclusions of an expert panel that discussed four case studies; these were examples of patients typically encountered by nurses working in the community. The panel considered the nutritional and lifestyle advice that could be given by nurses relating to conditions such as irritable bowel syndrome (IBS), depression, chronic fatigue syndrome, vulnerability to common infections, elderly care, recurrent urinary tract infection, antibiotic use, and risk of type 2 diabetes. A general conclusion was the importance of motivational interviewing techniques in achieving full understanding of patients' concerns and to determine the best health strategy. As well as specific guidance appropriate for each disorder, a range of information sources for both health professionals a...



Establishing Clinically Relevant Severity Levels for the Central Sensitization Inventory

Tue, 01 Mar 2016 00:00:00 +0100

ConclusionThis study provides support for these CSI severity levels as a guideline for healthcare providers and researchers in interpreting CSI scores and evaluating treatment responsiveness. (Source: Pain Practice)



Chronic fatigue syndrome and experience with the Lightning Process.

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Landmark L, Lindgren RM, Sivertsen B, Magnus P, Conradi S, Thorvaldsen SN, Stanghelle JK PMID: 26983138 [PubMed - as supplied by publisher] (Source: Tidsskrift for den Norske Laegeforening)

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Gender Differences in Chronic Fatigue Syndrome

Mon, 29 Feb 2016 00:00:00 +0100

Conclusions The clinical phenotype of the men with CFS was young, single, skilled worker, and infection as the main triggering agent. Men had less pain and less muscle and immune symptoms, fewer comorbid phenomena, and a better quality of life. (Source: Reumatologia Clinica)



Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) Register - Roberts E, Wessely S, Chalder T, Chang CK, Hotopf M.

Sat, 27 Feb 2016 13:08:11 +0100

BACKGROUND: Mortality associated with chronic fatigue syndrome is uncertain. We investigated mortality in individuals diagnosed with chronic fatigue syndrome in secondary and tertiary care using data from the South London and Maudsley NHS Foundation Trust ... (Source: SafetyLit)



Aspects of posttraumatic stress disorder in long-term testicular cancer survivors: cross-sectional and longitudinal findings

Fri, 26 Feb 2016 00:00:00 +0100

Conclusions In spite of excellent prognosis, 10.9 % of long-term testicular cancer survivors had Probable PTSD at a mean of 11 years after diagnosis. Probable PTSD was significantly associated with a broad range of problems both at that time and was predictive of considerable problems at a mean of 19 year postdiagnosis. Implications for cancer survivors Among long-term testicular cancer survivors, 10.9 % have Probable PTSD with many associated problems, and therefore health personnel should explore stress symptoms at follow-up since efficient treatments are available. (Source: Journal of Cancer Survivorship)



The Relation Between Child Versus Parent Report of Chronic Fatigue and Language/Literacy Skills in School-Age Children with Cochlear Implants

Thu, 25 Feb 2016 03:19:27 +0100

Conclusions: Taken as a whole, results suggested that parents under-estimate the fatigue experienced by children with cochlear implants. Child report of physical fatigue was robustly related to language and literacy skills. Children with cochlear implants are likely more accurate at reporting physical fatigue than cognitive fatigue. Clinical practice should take fatigue into account when developing treatment plans for children with cochlear implants, and research should continue to develop a comprehensive model of fatigue in children with cochlear implants. (Source: Ear and Hearing)



Human Placental Extract as a Subcutaneous Injection is effective in Chronic Fatigue Syndrome.

Thu, 25 Feb 2016 00:00:00 +0100

Authors: Park SB, Kim KN, Sung E, Lee SY, Shin HC Abstract Chronic Fatigue (CF) is a common reason for consulting a physician due to affecting quality of life, but only a few effective treatments are available. The aim of this study was to examine the effectiveness of subcutaneous injection of the human placental extract (HPE) on medically indescribable cases of CF and safety in a randomized, double-blind, placebo-controlled clinical trial. A total of seventy eight subjects with CF were randomly assigned to either a HPE group or a placebo group. Subjects in the HPE group were treated with HPE three times a week subcutaneously for 6 weeks, whereas those in the placebo group with normal saline. Then, the Fatigue Severity Scale (FSS), Visual Analog Scale (VAS) and Multidimensional Fat...

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Heat shock proteins and chronic fatigue in primary Sjögren's syndrome.

Thu, 25 Feb 2016 00:00:00 +0100

Authors: Bårdsen K, Nilsen MM, Kvaløy JT, Norheim KB, Jonsson G, Omdal R Abstract Fatigue occurs frequently in patients with cancer, neurological diseases and chronic inflammatory diseases, but the biological mechanisms that lead to and regulate fatigue are largely unknown. When the innate immune system is activated, heat shock proteins (HSPs) are produced to protect cells. Some extracellular HSPs appear to recognize cellular targets in the brain, and we hypothesize that fatigue may be generated by specific HSPs signalling through neuronal or glial cells in the central nervous system. From a cohort of patients with primary Sjögren's syndrome, 20 patients with high and 20 patients with low fatigue were selected. Fatigue was evaluated with a fatigue visual analogue scale. Plasma c...



Extended B cell phenotype in patients with myalgic encephalomyelitis/chronic fatigue syndrome: a cross‐sectional study

Mon, 22 Feb 2016 00:00:00 +0100

In conclusion, we identified possible changes in B cell phenotype in patients with ME/CFS. These may reflect altered B cell function and, if confirmed in other patient cohorts, could provide a platform for studies based on clinical course or responsiveness to rituximab therapy. (Source: Clinical and Experimental Immunology)



IV Therapy “Cocktail” For a Cancer Patient

Fri, 19 Feb 2016 17:40:19 +0100

Today, I want to talk to you about my patient D.B. A key treatment I offer at the Sears Institute for Anti-Aging Medicine turned her life around and boosted her chances of recovering from cancer. D.B had been a vivacious 47-year-old woman, who’d always led a healthy life. For years, she’d watched her diet carefully and exercised regularly. But then she was diagnosed with endometrial cancer. This is cancer of the inner lining of the uterus. When she came to my clinic, she’d already undergone a hysterectomy and chemotherapy. Unsurprisingly, she felt terrible. She was pale. She felt lethargic and she was experiencing severe mental fog. Every moment of her life had become a struggle. It was clear right away that D.B. was deficient in several important nutrients. It was also clear her im...



A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis.

Fri, 19 Feb 2016 12:36:02 +0100

Conclusions. The results suggest significant deficits in the expression of receptors and adhesion molecules on subsets of CD8+ T cells in both MS and CFS/ME patients. These deficits reported may contribute to the pathogenesis of these diseases. However, larger sample size is warranted to confirm and support these encouraging preliminary findings. PMID: 26881265 [PubMed - in process] (Source: Journal of Immunology Research)



Development of a group-based self-management programme for individuals with chronic fatigue syndrome: a pilot study.

Thu, 18 Feb 2016 05:56:02 +0100

CONCLUSION: In line with the participants' experiences, the final self-management programme was developed, which includes short presentations of eight topics, exchange of experiences among participants, goal-setting, construction of action plans, and relaxation exercises, in addition to a meeting for relatives. The programme will be provided in eight biweekly sessions and be led by juxtaposed peer counsellors and occupational therapists. The effects of the final programme will be evaluated in a randomized controlled trial. PMID: 25581161 [PubMed - indexed for MEDLINE] (Source: Scandinavian Journal of Occupational Therapy)

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Protracted effects of chronic stress on serotonin-dependent thermoregulation.

Thu, 18 Feb 2016 02:41:06 +0100

Authors: Natarajan R, Northrop NA, Yamamoto BK Abstract Chronic stress is known to affect serotonin (5HT) neurotransmission in the brain and to alter body temperature. The body temperature is controlled in part, by the medial preoptic area (mPOA) of the hypothalamus. To investigate the effect of chronic stress on 5HT and how it affects body temperature regulation, we examined whether exposure to a chronic unpredictable stress (CUS) paradigm produces long-term alterations in thermoregulatory function of the mPOA through decreased 5HT neurotransmission. Adult male Sprague-Dawley rats underwent 21 d of CUS. Four days after the last stress exposure, basal body temperature in the home cage and body temperature in a cold room maintained at 10 °C were recorded. The CUS rats had signi...



Finding benefit in stressful uncertain circumstances: relations to social support and stigma among women with unexplained illnesses.

Thu, 18 Feb 2016 02:41:06 +0100

Authors: McInnis OA, McQuaid RJ, Bombay A, Matheson K, Anisman H Abstract Living with a chronic illness can be challenging, but the ability to derive benefits and grow from this experience may enhance well-being. However, the possibility of obtaining such benefits may be dependent on the levels of stigmatization and lack of social support experienced by an individual as a result of the illness. Chronic fatigue syndrome (CFS) and fibromyalgia are chronic conditions that remain largely unexplained and those with these conditions must often contend with stigma and skepticism from others. Individuals with CFS/fibromyalgia often display stress-related biological alterations and the experience of stressful life events has been associated with illness development. The present study demons...



Treatment expectations influence the outcome of multidisciplinary rehabilitation treatment in patients with CFS

Tue, 16 Feb 2016 00:00:00 +0100

To improve the effectiveness of treatment in patients with chronic fatigue syndrome it is worthwhile studying factors influencing outcomes. The aims of this study were (1) to assess the association of expectancy and credibility on treatment outcomes, and (2) to identify baseline variables associated with treatment expectancy and credibility. (Source: Journal of Psychosomatic Research)



‘It was like being buried alive’: battle to recover from chronic fatigue syndrome

Mon, 15 Feb 2016 08:15:05 +0100

Is it physical or mental – or a combination of the two? Does chronic fatigue syndrome, or ME, even exist? In an extract from her book Cure, Jo Marchant tells the story of Samantha Miller, one sufferer of the controversial conditionRead an interview with Jo Marchant, author of Cure, which looks at the mind’s proven ability to heal the body‘It was like being buried alive,” Samantha Miller says matter-of-factly, fixing me with blue eyes as she munches on falafel. “I was exhausted, with terrible joint pains. It was like having flu all the time with no certainty of recovery. I couldn’t do anything. I was trapped.”Today, she looks vibrant and younger than her 46 years. She is immaculately dressed in 1950s-inspired floral pinks with a fluffy beret and bright lipstick; her blonde hai...



Book reviews.

Sun, 14 Feb 2016 21:12:02 +0100

Authors: Littlewood R Abstract Speak of the Devil: Tales of Satanic Abuse in Contemporary England J. S. La Fontaine Cambridge University Press, 1998, xi + 224 pp., notes, bibliography. Chronic Fatigue Syndrome Shlomo Yehuda & David Mortofsky (eds) Plenum Publishers, 199 pp., diagrams, figures. $79.50 War and Ethnicity: Global Connections and Local Violence David Turton (ed.) University of Rochester Press, 270 pp., bibliography, notes, index. £49.50. Methods, Sex and Madness Julia O'Connell Davidson & Derek Layder Routledge, 1996, xii + 240 pp., index, figures, bibliography. From Feasting to Fasting, the Evolution of a Sin: Attitudes to Food in Late Antiquity Veronica E. Grimm Routledge, 1997, x+294pp., notes, index. £40.00. PMID: 26868883 [PubMed] (Source: Anthropolo...

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Novel investigational drugs mimicking exercise for the treatment of cachexia.

Sun, 14 Feb 2016 14:09:02 +0100

Authors: Penna F, Pin F, Ballarò R, Baccino FM, Costelli P Abstract INTRODUCTION: Cachexia is a syndrome characterized by body weight loss, muscle wasting and metabolic abnormalities, that frequently complicates the management of people affected by chronic diseases. No effective therapy is actually available, although several drugs are under clinical evaluation. Altered energy metabolism markedly contributes to the pathogenesis of cachexia; it can be improved by exercise, which is able to both induce anabolism and inhibit catabolism. AREAS COVERED: This review focuses on exercise mimetics and their potential inclusion in combined protocols to treat cachexia. The authors pay with particular reference to the cancer-associated cachexia. EXPERT OPINION: Even though exercise im...



Autoantibody pain

Sun, 14 Feb 2016 00:00:00 +0100

Publication date: Available online 12 February 2016 Source:Autoimmunity Reviews Author(s): Andreas Goebel As autoantibodies bind to target tissues, Fc-region dependent inflammation can induce pain via mediators exciting nociceptors. But recently another possibility has emerged, where autoantibody binding to nociceptors can directly cause pain, without inflammation. This is thought to occur as a result of Fab-region mediated modification of nerve transduction, transmission, or neuropeptide release. In three conditions, complex regional pain syndrome, anti-voltage gated potassium channel complex autoimmunity, and chronic fatigue syndrome, all associated with no or only little inflammation, initial laboratory-, and trial-results have suggested a potential role for autoantibody-mediated mec...



Gulf War Illness Major Health Effect Linked to Gulf War Military Service

Fri, 12 Feb 2016 05:19:12 +0100

Although more than $500 million in federally funded research on Persian Gulf War veterans has produced many findings, there has been little substantial progress in the overall understanding of health effects, particularly Gulf War illness, resulting from military service in the war, says a new Academies report. Aligning with conclusions in a 2010 report, the committee that carried out the latest study said veterans who were deployed to the Gulf War appear to have an increased risk for Gulf War illness, chronic fatigue syndrome, functional gastrointestinal conditions, and mental health disorders such as post-traumatic stress disorder, generalized anxiety disorder, depression, and substance abuse. There is some evidence that service during the conflict is linked to amyotrophic lateral sclero...



Development of the Sensory Hypersensitivity Scale (SHS): a self-report tool for assessing sensitivity to sensory stimuli

Fri, 12 Feb 2016 00:00:00 +0100

Abstract Sensory hypersensitivity is one manifestation of the central sensitization that may underlie conditions such as fibromyalgia and chronic fatigue syndrome. We conducted five studies designed to develop and validate the Sensory Hypersensitive Scale (SHS); a 25-item self-report measure of sensory hypersensitivity. The SHS assesses both general sensitivity and modality-specific sensitivity (e.g. touch, taste, and hearing). 1202 participants (157 individuals with chronic pain) completed the SHS, which demonstrated an adequate overall internal reliability (Cronbach’s alpha) of 0.81, suggesting the tool can be used as a cross-modality assessment of sensitivity. SHS scores demonstrated only modest correlations (Pearson’s r) with depressive symptoms (0.19) and anxiety (0.28), ...



Fatigue in muscular dystrophy and metabolic myopathy

Thu, 11 Feb 2016 06:20:00 +0100

Muscular dystrophy is a heterogeneous group of disorders characterized by decreased muscle mass, atrophy and connective tissue proliferation. nNOS (nitric oxide synthase) is an important regulator of vascular blood flow.Metabolic myopathies mare disorders of utilization of carbohydrates and fatty acids in muscle. The acute nature of energy failure is manifested either by a metabolic crisis (CPT-II deficiency), muscle weakness sometimes associated with respiratroy failure (GSDII). The discovery of a new syndrome, NLSD-M (neutral lipid storage disorder), introduces the need of the response to therapy, either dietary or medical, to prevent for each disorder the chronic fatigue, the respiratory insufficiency and cardiomyopathy. (Source: Clinical Neurophysiology)

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ID 446 – Fatigue in muscular dystrophy and metabolic myopathy

Thu, 11 Feb 2016 06:19:56 +0100

Muscular dystrophy is a heterogeneous group of disorders characterized by decreased muscle mass, atrophy and connective tissue proliferation. nNOS (nitric oxide synthase) is an important regulator of vascular blood flow.Metabolic myopathies mare disorders of utilization of carbohydrates and fatty acids in muscle. The acute nature of energy failure is manifested either by a metabolic crisis (CPT-II deficiency), muscle weakness sometimes associated with respiratory failure (GSDII). The discovery of a new syndrome, NLSD-M (neutral lipid storage disorder), introduces the need of the response to therapy, either dietary or medical, to prevent for each disorder the chronic fatigue, the respiratory insufficiency and cardiomyopathy. (Source: Clinical Neurophysiology)



Extension of recovery time from fatigue by repeated rest with short‐term sleep during continuous fatigue load: Development of chronic fatigue model

Thu, 11 Feb 2016 00:00:00 +0100

Homeostasis is known to be involved in maintaining the optimal internal environment, helping to achieve the best performance of biological functions. At the same time, a deviation from optimal conditions often attenuates the performance of biological functions, and such restricted performance could be considered as individual fatigue, including physical and mental fatigue. The present study seeks to develop an animal model of chronic or subacute fatigue in which the recovery time is extended through the gradual disruption of homeostasis. We show that repeated short‐term rest periods with certain lengths of sleep during continuous fatigue loading extend recovery from spontaneous nighttime activity but not physical performance in comparison with a continuous fatigue‐loading procedure. Fu...



Assessing the reliability of the Five Minute Speech Sample against the Camberwell Family Interview in a Chronic Fatigue Syndrome sample

Thu, 11 Feb 2016 00:00:00 +0100

The current study aimed to examine the reliability of the Five Minute Speech Sample (FMSS) for assessing relative Expressed Emotion (EE) compared with the Camberwell Family Interview (CFI) in a sample of relatives of adult patients with Chronic Fatigue Syndrome (CFS). (Source: Comprehensive Psychiatry)



Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study

Thu, 11 Feb 2016 00:00:00 +0100

Abstract Exact low resolution electromagnetic tomography (eLORETA) was recorded from nineteen EEG channels in nine patients with myalgic encephalomyelitis (ME) and 9 healthy controls to assess current source density and functional connectivity, a physiological measure of similarity between pairs of distributed regions of interest, between groups. Current source density and functional connectivity were measured using eLORETA software. We found significantly decreased eLORETA source analysis oscillations in the occipital, parietal, posterior cingulate, and posterior temporal lobes in Alpha and Alpha-2. For connectivity analysis, we assessed functional connectivity within Menon triple network model of neuropathology. We found support for all three networks of the triple network model...



Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study.

Thu, 11 Feb 2016 00:00:00 +0100

Authors: Zinn ML, Zinn MA, Jason LA Abstract Exact low resolution electromagnetic tomography (eLORETA) was recorded from nineteen EEG channels in nine patients with myalgic encephalomyelitis (ME) and 9 healthy controls to assess current source density and functional connectivity, a physiological measure of similarity between pairs of distributed regions of interest, between groups. Current source density and functional connectivity were measured using eLORETA software. We found significantly decreased eLORETA source analysis oscillations in the occipital, parietal, posterior cingulate, and posterior temporal lobes in Alpha and Alpha-2. For connectivity analysis, we assessed functional connectivity within Menon triple network model of neuropathology. We found support for all three n...

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ME chronic fatigue sufferers are 6 times more likely to commit suicide

Wed, 10 Feb 2016 01:21:52 +0100

The King’s College London research, published in The Lancet medical journal, is the first to highlight suicide as a major risk factor for the condition, which is also known as M.E. (Source: the Mail online | Health)



Suicide risk in people with chronic fatigue syndrome

Wed, 10 Feb 2016 00:00:00 +0100

Publication date: Available online 10 February 2016 Source:The Lancet Author(s): Nav Kapur, Roger Webb (Source: The Lancet)



Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) Register

Wed, 10 Feb 2016 00:00:00 +0100

Publication date: Available online 10 February 2016 Source:The Lancet Author(s): Emmert Roberts, Simon Wessely, Trudie Chalder, Chin-Kuo Chang, Matthew Hotopf Background Mortality associated with chronic fatigue syndrome is uncertain. We investigated mortality in individuals diagnosed with chronic fatigue syndrome in secondary and tertiary care using data from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) register. Methods We calculated standardised mortality ratios (SMRs) for all-cause, suicide-specific, and cancer-specific mortality for a 7-year observation period using the number of deaths observed in SLaM records compared with age-specific and sex-specific mortality statistics for England and W...






Chronic fatigue syndrome: comparing outcomes in White British and Black and minority ethnic patients after cognitive-behavioural therapy.

Tue, 09 Feb 2016 06:09:02 +0100

ConclusionsTo our knowledge, this study is the first to indicate that CBT is effective for treating CFS in a group of patients from diverse BME backgrounds. PMID: 26846611 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)

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Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome

Tue, 09 Feb 2016 00:00:00 +0100

Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome Translational Psychiatry 6, e730 (February 2016). doi:10.1038/tp.2015.208 Authors: K A Schlauch, S F Khaiboullina, K L De Meirleir, S Rawat, J Petereit, A A Rizvanov, N Blatt, T Mijatovic, D Kulick, A Palotás & V C Lombardi (Source: Translational Psychiatry)



Neurocognitive improvements after best-practice intervention for chronic fatigue syndrome: Preliminary evidence of divergence between objective indices and subjective perceptions

Tue, 09 Feb 2016 00:00:00 +0100

Neurocognitive difficulties are commonly reported by patients suffering from chronic fatigue syndrome (CFS). Moderate improvements from ‘best practice’ therapy are promising, but to date reported efficacy is based entirely on subjective measures. This is problematic, given the well-documented divergence between subjective perceptions and actual neurocognitive performance, including in this patient group. (Source: Comprehensive Psychiatry)



Exercise therapy for chronic fatigue syndrome.

Sun, 07 Feb 2016 00:00:00 +0100

CONCLUSIONS: Patients with CFS may generally benefit and feel less fatigued following exercise therapy, and no evidence suggests that exercise therapy may worsen outcomes. A positive effect with respect to sleep, physical function and self-perceived general health has been observed, but no conclusions for the outcomes of pain, quality of life, anxiety, depression, drop-out rate and health service resources were possible. The effectiveness of exercise therapy seems greater than that of pacing but similar to that of CBT. Randomised trials with low risk of bias are needed to investigate the type, duration and intensity of the most beneficial exercise intervention. PMID: 26852189 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)



Label free analysis of human cerebrospinal fluid addressing various normalization strategies and revealing protein groups affected by multiple sclerosis

Wed, 03 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Proteomics)



Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, hybridization and PCR to detect Coxsackievirus B1 in A549 cells

Tue, 02 Feb 2016 00:00:00 +0100

Enterovirus1 (EV) infections are common in all age groups. They are usually asymptomatic or cause only mild respiratory symptoms, but can also lead to more severe illness including hand, foot and mouth disease, myocarditis, meningitis, encephalitis, pancreatitis, systemic infection in newborns and paralysis. EV infections may also play a role in the pathogenesis of chronic diseases such as dilated cardiomyopathy [1], chronic fatigue syndrome [2] and type 1 diabetes2 (T1D) [3–5]. (Source: Journal of Clinical Virology)

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Orosomucoid (ORM) as a Potential Biomarker for the Diagnosis of Chronic Fatigue Syndrome (CFS).

Tue, 02 Feb 2016 00:00:00 +0100

Authors: Sun Y, Zhang ZX, Liu X PMID: 26833758 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)



Chronic Fatigue Syndrome at Age 16 Years

Mon, 01 Feb 2016 00:00:00 +0100

CONCLUSIONS: CFS affected 1.9% of 16-year-olds in a UK birth cohort and was positively associated with higher family adversity. Gender was a risk factor at age 16 years but not at age 13 years or in 16-year-olds without high levels of depressive symptoms. (Source: PEDIATRICS)



Investigation of suspected chronic fatigue syndrome/myalgic encephalopathy.

Mon, 01 Feb 2016 00:00:00 +0100

This study reports diagnoses and findings upon assessment, and considers the benefit of supplementary examinations.MATERIAL AND METHOD Diagnoses and findings from examinations of 365 patients assessed for suspected chronic fatigue syndrome/myalgic encephalopathy are retrospectively reported.RESULTS A total of 48 patients (13.2 %) were diagnosed with chronic fatigue syndrome/myalgic encephalopathy, while a further 18 patients (4.9 %) were diagnosed with post-infectious fatigue. Mental and behavioural disorders were diagnosed in 169 patients (46.3 %), and these represented by far the largest group. Serious, but unrecognised somatic illness was discovered in two patients, while changes of uncertain significance were detected by MRI and lumbar puncture in a few patients.INTERPRETATION Fatig...



Self-Reported Migraine and Chronic Fatigue Syndrome Are More Prevalent in People with Myofascial vs Nonmyofascial Temporomandibular Disorders.

Thu, 28 Jan 2016 18:59:02 +0100

CONCLUSION: Individuals with myofascial TMD had a higher prevalence of self-reported migraine and chronic fatigue syndrome than those with nonmyofascial TMD. PMID: 26817027 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)



Your body’s “other” pulse

Wed, 27 Jan 2016 19:58:22 +0100

When I take a patient’s pulse, I’m really checking to make sure their heart is beating in rhythm and their blood is flowing regularly. It wasn’t until much later that I learned your body has another pulse — your “dural pulse.” In the 1970s, Dr. John Upledger discovered the dural pulse. He was studying dural tubes at the College of Osteopathic Medicine at Michigan State University. The dural tube is a membrane surrounding your spinal cord. It’s filled with cerebral spinal fluid. Dr. Upledger noticed that this spinal fluid moves with a set rhythm. In fact, this dural pulse beats at 6 to 12 cycles per minute. While the dural pulse is still completely ignored by Western medicine, this central nervous system network of tissues, bones and fluids at the core of your body beats like ...

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How Common Is Chronic Fatigue Syndrome In Teens?

Wed, 27 Jan 2016 12:00:00 +0100

Chronic fatigue syndrome is a multi-system disease that is not well understood by the medical community. A new report suggests that between 2-3% of 16-year-olds suffer from the debilitating disease. (Source: Forbes.com Healthcare News)



2 percent of U.K. 16-year-olds have chronic fatigue syndrome

Mon, 25 Jan 2016 17:18:29 +0100

Stephen FellerBRISTOL, England, Jan. 25 (UPI) -- Researchers were surprised to find higher rates of chronic fatigue syndrome in teenagers than has been expected, based on surveys of parents and teenagers. (Source: Health News - UPI.com)



Medical News Today: 'More teens affected by CFS than previously recognized'

Mon, 25 Jan 2016 16:00:00 +0100

Researchers estimate that around 1 in 50 16-year-olds have chronic fatigue syndrome lasting 6 months or more, highlighting how common the disorder is in this age group. (Source: Health News from Medical News Today)



1 in 50 16-year-olds affected by chronic fatigue syndrome

Mon, 25 Jan 2016 11:35:00 +0100

In what is believed to be the biggest study of chronic fatigue syndrome (CFS) – also known as myalgic encephalomyelitis (ME) – in children to date, researchers at the University of Bristol have found that almost two per cent of 16-year-olds have CFS lasting more than six months, and nearly three per cent have CFS lasting more than three months (the UK definition). Those with CFS missed, on average, more than half a day of school every week. (Source: University of Bristol news)



Chronic fatigue up among 16-year-olds

Mon, 25 Jan 2016 05:54:41 +0100

Chronic fatigue syndrome is more common than previously thought, particularly among girls at the age of 16, research by the University of Bristol suggests. (Source: BBC News | Health | UK Edition)

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Comment on: 'Reports of recovery in chronic fatigue syndrome may present less than meets the eye

Thu, 21 Jan 2016 00:00:00 +0100

Dear Editor, Friedberg and Adamowicz reviewed our paper about recovery from chronic fatigue syndrome (CFS) after treatment in the PACE trial.1–3 We write in order to correct some errors of fact and interpretation in their review. The authors suggest that we did not use any measures of patients’ perceptions of recovery. In fact we used the patient-rated clinical global impression change score of their overall health,4 which included those who rated their overall health as ‘much’ and "very much better", and which was one of the five criteria counting towards recovery. In their account of our paper, the reviewers omitted to mention one of the criteria for recovery we used—being ineligible for entry into the trial.2 The reviewers themselves defined recovery as a &...



Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome

Wed, 20 Jan 2016 00:00:00 +0100

Conclusions: Analysis of mitochondrial genomes in ME/CFS cases indicates that individuals of a certain haplogroup or carrying specific SNPs are more likely to exhibit certain neurological, inflammatory, and/or gastrointestinal symptoms. No increase in susceptibility to ME/CFS of individuals carrying particular mitochondrial genomes or SNPs was observed. (Source: Journal of Translational Medicine)



Cerebral microglia activation in hepatitis C virus infection correlates to cognitive dysfunction

Sat, 16 Jan 2016 07:15:18 +0100

Summary Hepatitis C virus (HCV) infection may induce chronic fatigue and cognitive dysfunction. Virus replication was proven within the brain and HCV‐positive cells were identified as microglia and astrocytes. We hypothesized that cerebral dysfunction in HCV‐afflicted patients is associated with microglia activation. Microglia activation was assessed in vivo in 22 patients with chronic HCV infection compared to six healthy controls using [11C]‐PK11195 Positron Emission Tomography (PET) combined with magnetic resonance tomography for anatomical localization. Patients were subdivided with regard to their PCR status, Fatigue Impact Scale score (FIS) and attention test sum score (ATS). A total of 12 patients (54.5%) were HCV PCR positive [of which 7 (58.3%) had an abnormal FIS and 7 (58....



Increased expression of activation antigens on CD8+ T lymphocytes in Myalgic Encephalomyelitis/chronic fatigue syndrome: inverse associations with lowered CD19+ expression and CD4+/CD8+ ratio, but no associations with (auto)immune.

Fri, 15 Jan 2016 07:45:03 +0100

CONCLUSIONS: The results support that a) increased CD38 and HLA-DR expression on CD8+ T cells are biomarkers of ME/CFS; b) increased CD38 antigen expression may contribute to suppression of the CD4+/CD8+ ratio and CD19+ expression; c) there are different immune subgroups of ME/CFS patients, e.g. increased CD8+ activation marker expression versus inflammation or O&NS processes; and d) viral infections or reactivation may play a role in a some ME/CFS patients. PMID: 26707044 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)



"Diagnostic concordance between categorical and dimensional instruments to assess personality disorder in chronic fatigue sydrome": Correction to Calvo et al., 2015.

Thu, 14 Jan 2016 00:00:00 +0100

Reports an error in "Diagnostic Concordance Between Categorical and Dimensional Instruments to Assess Personality Disorder in Chronic Fatigue Syndrome: PDQ-4+ and TCI-R" by Natalia Calvo, Naia Sáez-Francàs, Sergi Valero, Jesús Castro-Marrero, José Alegre Martín and Miquel Casas (European Journal of Psychological Assessment, Advanced Online Publication, Aug 28, 2015, np). The correct author affiliations are present in the erratum. (The following abstract of the original article appeared in record 2015-42715-001.) Abstract. The study examines the relationship between a categorical and a dimensional personality assessment instrument in patients with Chronic Fatigue Syndrome (CFS). A total of 162 CFS patients were included in the study (91.4% women; mean age 47.5 years). All subjects comp...

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Boiogito Increases the Metabolism of Fatty Acids in Proximal Tubular Cells through Peroxisome Proliferators-Activated Receptor (PPAR) α Agonistic Activity.

Wed, 13 Jan 2016 11:40:02 +0100

In this study, BO and Astragalus Root (AsR), a constituent crude drug of BO, were administered orally to intravenously bovine serum albumin (BSA)-administered mice to evaluate the PPARα-cAMP responsive element binding protein (CREB) binding protein (CBP) complex binding activity and/or mRNA expression of PPARα, as quantified by enzyme-linked immunosorbent assay (ELISA) and/or polymerase chain reaction (PCR). Increases in PPARα-CBP complex binding activity and the expression of PPARα mRNA were observed not only in BO-administered mice but also in AsR-administered mice, accompanied by a decrease in the amount of renal fatty acid. PMID: 26725438 [PubMed - in process] (Source: Biological and Pharmaceutical Bulletin)



Mercury in vaccines causes cellular mitochondria to suffocate and die

Tue, 12 Jan 2016 06:00:00 +0100

(NaturalNews) Mitochondrial damage is known to play a key role in a wide range of disorders, including schizophrenia, diabetes, Parkinson's disease, epilepsy, migraine, strokes, chronic fatigue syndrome and autism. Only recently it has been discovered that most mitochondrial damage... (Source: NaturalNews.com)



Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome

Tue, 12 Jan 2016 00:00:00 +0100

Publication date: February 2016 Source:Brain, Behavior, and Immunity, Volume 52 Author(s): Madlen Loebel, Patricia Grabowski, Harald Heidecke, Sandra Bauer, Leif G. Hanitsch, Kirsten Wittke, Christian Meisel, Petra Reinke, Hans-Dieter Volk, Øystein Fluge, Olav Mella, Carmen Scheibenbogen Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in CFS point to an autoimmune disease directed against neurotransmitter receptors. Autoantibodies against G-protein coupled receptors were shown to play a pathogenic role in several autoimmune diseases. Here, serum samples from a patient cohort from Berlin (n =268) and from Bergen with pre- and post-treatment samples from 25 patients treated within the KTS-2 rituximab trial were analysed for IgG against ...



Screening questionnaires for sleep-disordered breathing and six-minute walk test in patients attending cardiac rehabilitation

Fri, 08 Jan 2016 00:00:00 +0100

Sleep-disordered Breathing (SDB) is a prevalent but under-recognized condition characterized clinically by habitual snoring, chronic fatigue, and excessive daytime sleepiness. Epidemiological studies have established a strong association between SDB and cardiovascular diseases [1–3]. There is a global shortage of sleep laboratory, resulting in a delay in diagnosis [4]. To overcome this shortage, screening questionnaires including the (a) Berlin Questionnaire (BQ), (b) Snoring, daytime Tiredness, Observed apneas and high blood Pressure-Body Mass Index, Age, Neck circumference and male Gender (STOP-BANG), and (c) Epworth Sleepiness Scale (ESS) have been increasingly used in clinical settings including cardiac rehabilitation to preliminarily stratify patients at risk for SDB. (Source: Inter...



Dry Eye Syndrome Risks in Patients With Fibromyalgia: A National Retrospective Cohort Study

Fri, 01 Jan 2016 06:00:00 +0100

Abstract: The coexistence of fibromyalgia (FM) and dry eye syndrome (DES) has been previously reported. However, there are few studies on how patients with FM may develop concomitant DES. Patients with chronic widespread pain, like FM, chronic fatigue syndrome, and irritable bowel syndrome (IBS), was concerned for the rheumatic or psychosomatic disorders which might adequately reflect the long-term risk of DES. We retrieved data on FM patients from the National Health Insurance Research Database of Taiwan covering the years 2000 to 2011. Our FM population consisted of 25,777 patients versus 103,108 patients in the non-FM group: the overall incidence of DES in these populations was 7.37/10,000 and 4.81/10,000, respectively. Male FM patients had a higher incidence of DES, with a 1.39-fold ...

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Significant other behavioural responses and patient chronic fatigue syndrome symptom fluctuations in the context of daily life: An experience sampling study.

Thu, 24 Dec 2015 00:00:00 +0100

CONCLUSION: The results indicate that significant other responses are important influences on the day-to-day experience of CFS/ME. Further research examining patient outcomes in association with specific significant other behavioural responses is warranted and future interventions that target such significant other behaviours may be beneficial. Statement of contribution What is already known on this subject? The existing literature has identified that significant other responses are important with respect to patient outcomes in CFS/ME. In particular, when examined cross-sectionally and longitudinally, negative and solicitous significant other responses are associated with poorer illness outcomes. This study is the first to examine the momentary associations between negative and solicitous ...



Temperament vs. chronic fatigue in police officers - Stępka E, Basińska MA.

Wed, 23 Dec 2015 02:27:22 +0100

BACKGROUND: Chronic fatigue is a problem affecting a still growing number of people. Among them there are representatives of different professions who are forced to cope not only with occupational stress, but also with the problem of fatigue. The police i... (Source: SafetyLit)



Chronic Fatigue Syndrome (CFS) symptom-based phenotypes in two clinical cohorts of adult patients in the UK and The Netherlands

Tue, 22 Dec 2015 00:00:00 +0100

Studies have provided evidence of heterogeneity within chronic fatigue syndrome (CFS), but few have used data from large cohorts of CFS patients or replication samples. (Source: Journal of Psychosomatic Research)



Are Myalgic Encephalomyelitis and chronic fatigue syndrome different illnesses? A preliminary analysis

Mon, 21 Dec 2015 00:00:00 +0100

Considerable discussion has transpired regarding whether chronic fatigue syndrome is a distinct illness from Myalgic Encephalomyelitis. A prior study contrasted the Myalgic Encephalomyelitis International Consensus Criteria with the Fukuda and colleagues’ chronic fatigue syndrome criteria and found that the Myalgic Encephalomyelitis International Consensus Criteria identified a subset of patients with greater functional impairment and physical, mental, and cognitive problems than the larger group who met Fukuda and colleagues’ criteria. The current study analyzed two discrete data sets and found that the Myalgic Encephalomyelitis International Consensus Criteria identified more impaired individuals with more severe symptomatology. (Source: Journal of Health Psychology)



Self-critical perfectionism predicts lower cortisol response to experimental stress in patients with chronic fatigue syndrome.

Mon, 21 Dec 2015 00:00:00 +0100

Conclusion: Our findings suggest that SCP is associated with loss of resilience of the neurobiological stress response system in CFS. (PsycINFO Database Record (c) 2016 APA, all rights reserved) (Source: Health Psychology)

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An adolescent evaluated for chronic fatigue: does she have a sleep disorder?

Sun, 20 Dec 2015 23:44:52 +0100

Authors: Gonzalez M, Fisher M Abstract A 13-year-old girl presented to our Division of Adolescent Medicine for evaluation of ongoing fatigue. She and her mother reported that 15 months earlier, when the patient was in the 7th grade, she started to be tired and "sleep all the time." They do not remember her being ill at that time; a test for mononucleosis was reportedly positive, but Epstein-Barr virus titers showed "old disease." She remained fatigued throughout 7th grade but attended school without falling asleep; however, she was too tired to do her work and had to attend summer school. The patient received home instruction in 8th grade and reported that on weekdays she slept from 1 AM to 11 AM with a nap from 4 to 8 PM and on weekends she slept from 3 AM to 1 PM without a nap. ...



Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Fri, 18 Dec 2015 00:00:00 +0100

by Sanjay K. Shukla, Dane Cook, Jacob Meyer, Suzanne D. Vernon, Thao Le, Derek Clevidence, Charles E. Robertson, Steven J. Schrodi, Steven Yale, Daniel N. Frank Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by intense and debilitating fatigue not due to physical activity that has persisted for at least 6 months, post-exertional malaise, unrefreshing sleep, and accompanied by a number of secondary symptoms, including sore throat, memory and concentration impairment, headache, and muscle/joint pain. In patients with post-exertional malaise, significant worsening of symptoms occurs following physical exertion and exercise challenge serves as a useful method for identifying biomarkers for exertion intolerance. Evidence suggests that intestinal dysbiosi...



Abnormal resting state functional connectivity in patients with chronic fatigue syndrome: An arterial spin-labeling fMRI study

Thu, 17 Dec 2015 00:00:00 +0100

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder characterized by severe fatigue and neurocognitive dysfunction. Recent work from our laboratory and others utilizing arterial spin labeling functional magnetic resonance imaging (ASL) indicated that ME/CFS patients have lower resting state regional cerebral blood flow (rCBF) in several brain areas associated with memory, cognitive, affective, and motor function. This hypoperfusion may underlie ME/CFS pathogenesis and may result in alterations of functional relationships between brain regions. (Source: Magnetic Resonance Imaging)



Microbes, molecular mimicry and molecules of mood and motivation

Wed, 16 Dec 2015 00:00:00 +0100

The hypothesis proposed is that functional disorders, such as irritable bowel syndrome, chronic fatigue syndrome and anorexia nervosa are caused by auto-antibodies to neuronal proteins induced by molecular mimicry with microbial antigens. The age incidence of these conditions, the marked female excess, increase with economic and technological advance, precipitation by infection, and the paucity of histological changes are all consistent with the hypothesis. It can be tested directly using human sera to search for cross reaction with brain proteins in model systems such as Drosophila melanogaster. (Source: Medical Hypotheses)



Effectiveness of a group-based self-management program for people with chronic fatigue syndrome: A randomized controlled trial.

Wed, 16 Dec 2015 00:00:00 +0100

CONCLUSIONS: The evaluated self-management program did not have any sustained effect, as compared with receiving usual care. PMID: 26672998 [PubMed - as supplied by publisher] (Source: Clinical Rehabilitation)

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Comprehensively understanding fatigue in patients with myeloproliferative neoplasms

Tue, 15 Dec 2015 00:00:00 +0100

CONCLUSIONSThe management of fatigue should be multifactorial, with a comprehensive assessment and treatment plan to address all modifiable fatigue etiologies. Patients with MPNs likely have a higher prevalence of mood disturbances compared with the general population, suggesting the need to assess and intervene in this domain. Cancer 2015. © 2015 American Cancer Society. (Source: Cancer)



"Lyme": Chronic Fatigue Syndrome by Another Name?

Mon, 14 Dec 2015 00:00:00 +0100

(Source: Clinical Infectious Diseases)



The many neuroprogressive actions of tryptophan catabolites (TRYCATs) that may be associated with the pathophysiology of neuro-immune disorders.

Mon, 14 Dec 2015 00:00:00 +0100

Authors: Morris G, Carvalho A, Anderson G, Galecki P, Maes M Abstract Many if not all chronic medical, neurodegenerative and neuroprogressive illnesses are characterised by chronic immune activation, oxidative and nitrosative stress (O&NS) and systemic inflammation. These environmental factors notably elevated pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase (IDO) leading to an upregulated tryptophan catabolite (TRYCAT) pathway of tryptophan degradation in the periphery and in the brain. In such conditions the TRYCAT pathway becomes the predominant system for tryptophan degradation in all body compartments. In this paper we review the pathways whereby TRYCATs may play a role in neuro-inflammatory and neuroprogressive disease. Thus chronic activation of the TRYCAT...



Kawasaki-like disease (KLD) in an adult with congenital HIV infection

Sun, 13 Dec 2015 00:00:00 +0100

Conclusion It is a challenging task to diagnose Kawasaki-like disease in HIV infected adults due to a high likelihood of opportunistic infections or possible hypersensitivity to any one of the plethora of prescribed medications. A high suspicion of KLD is advised in HIV infected adults with severe immunosuppression and unexplained fever lasting>5 days to ensure timely diagnosis and treatment. (Source: HIV and AIDS Review)



[The prevalence of low back pain in hospital staff and its relationship with chronic fatigue syndrome and occupational factors].

Sat, 12 Dec 2015 11:28:38 +0100

CONCLUSION: To the best of our knowledge, this is the first to show the relationship between low back pain and chronic fatigue syndrome in hospital employees. Shift work and length of time in occupation are risk factors for chronic fatigue syndrome. PMID: 26356104 [PubMed - in process] (Source: Agri Dergisi)

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Genetic and Environmental Influences on Disability Pension Due To Mental Diagnoses: Limited Importance of Major Depression, Generalized Anxiety, and Chronic Fatigue.

Wed, 09 Dec 2015 00:00:00 +0100

CONCLUSIONS: Large proportions of genetic and non-shared environmental influences in DP due to mood and neurotic diagnoses were not explained by the contributions from MD/GAD or CF. The results suggest that the process leading to DP is complex and influenced by factors other than those related to the disorder underlying DP. PMID: 26648005 [PubMed - as supplied by publisher] (Source: Twin Research and Human Genetics)



Extended B‐cell phenotype in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A cross‐sectional study

Tue, 08 Dec 2015 00:00:00 +0100

In conclusion, we identified possible changes in B‐cell phenotype in patients with ME/CFS. These may reflect altered B‐cell function and if confirmed in other patient cohorts, could provide a platform for studies based on clinical course or responsiveness to rituximab‐therapy. This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)



Extended B-cell phenotype in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A cross-sectional study.

Tue, 08 Dec 2015 00:00:00 +0100

In conclusion, we identified possible changes in B-cell phenotype in patients with ME/CFS. These may reflect altered B-cell function and if confirmed in other patient cohorts, could provide a platform for studies based on clinical course or responsiveness to rituximab-therapy. This article is protected by copyright. All rights reserved. PMID: 26646713 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)



It's time for doctors to apologise to their ME patients

Mon, 07 Dec 2015 09:35:58 +0100

For too long the medical community has dismissed 'Chronic Fatigue Syndrome' as a mental illness which can be cured with therapy and exercise (Source: Telegraph Health)



New acoustic wave therapy improves quality of life in patients with multiple sclerosis and chronic cerebrospinal venous insufficiency.

Wed, 02 Dec 2015 11:28:08 +0100

Authors: d'Alessandro A, Niglio T, Desogus A, d'Alessandro A, Mandolesi D Abstract UNLABELLED: A Multiple Sclerosis patient with chronic cerebrospinal venous insufficiency (CCSVI) treated by acoustic waves, modulated in frequency and power of the Dreno-MAM® device, showed a progressive improvement in motor coordination, resistance to work, muscular power and rigidity, and distal microcirculation. Life quality, chronic fatigue, and clinical severity questionnaires EDSS show marked improvements with a follow-up of two years. We suggest that the method could be also used in the chronic fatigue syndrome and other neurological diseases such as Parkinson or Meniere syndrome. Analyses on statistically robust samples are in progress to validate such impressive result obtained by this nonp...

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What Doctors Are Finally Starting To Understand About Chronic Fatigue

Tue, 01 Dec 2015 15:35:30 +0100

Eight years ago, Ann Cavanagh Kramer was promoted to director of commercial sales at Visa. She transferred across the country to work at the company's San Francisco Bay Area office and spent the next six months traveling to attend conferences and meet potential clients. She was, in her own words, "at the top of my game." But after running a half marathon in October 2007, she suffered back-to-back viral infections. Then she began experiencing dizzy spells and fatigue so intense, she'd sleep for 15 to 16 hours a day. "When I wasn't working, I was sleeping," says Cavanagh Kramer, 38. She thought she might have a sinus infection, bronchitis, or the flu. Or maybe pneumonia. "No one could figure out what was wrong with me." When her fatigue hadn't ebbed by the following year, Cavanagh Kramer was...



Kudos and Concerns About Chronic Fatigue

Tue, 01 Dec 2015 06:00:00 +0100

No abstract available (Source: Neurology Now)



The Editor Responds: Kudos and Concerns About Chronic Fatigue

Tue, 01 Dec 2015 06:00:00 +0100

No abstract available (Source: Neurology Now)

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Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Tue, 01 Dec 2015 00:00:00 +0100

Authors: Smith ME, Haney E, Nelson HD PMID: 26618296 [PubMed - in process] (Source: Annals of Internal Medicine)



Chronic fatigue syndrome/myalgic encephalo-myelitis - pathophysiology, diagnosis and treatment.

Tue, 01 Dec 2015 00:00:00 +0100

Authors: Wyller VB, Reme SE, Mollnes TE PMID: 26674040 [PubMed - as supplied by publisher] (Source: Tidsskrift for den Norske Laegeforening)



Effect of Lixujieyu recipe in combination with Five Elements music therapy on chronic fatigue syndrome.

Tue, 01 Dec 2015 00:00:00 +0100

CONCLUSION: Lixujieyu recipe combined with Gong-Tune or Jiao-Tune significantly relieved the symptoms of CFS. PMID: 26742307 [PubMed - in process] (Source: Journal of Traditional Chinese Medicine)



The Gluten-Free Frenzy: Fad or Fitting?

Mon, 30 Nov 2015 21:50:02 +0100

Authors: Johanson L Abstract Although the gluten-free diet has been recognized as therapeutic for individuals suffering from celiac disease, it has been promoted recently for other indications, such as autism, chronic fatigue syn- drome, and irritable bowel syndrome, or simply as a healthy dietary choice for anyone. The basics of the gluten-free diet are explored, with evidence-based indications and nursing implications when patients choose gluten-free. PMID: 26434032 [PubMed - indexed for MEDLINE] (Source: Medsurg Nursing : Official Journal of the Academy of Medical-Surgical Nurses)

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My Open Letter to Lyme Disease

Mon, 30 Nov 2015 00:22:31 +0100

Dear Lyme disease, I'm not angry. But I admit you made me miserable. You sneakily rushed through my veins. Anonymous, without a name, you tortured me for months. I didn't know who you were or where you came from. I would stare bleakly out my freshman dorm window, my eyes dull and my head throbbing. I blamed my school. During my first quarter at Northwestern University, my boyfriend and I broke up, my grandfather died, and I couldn't get out of bed for my morning classes. I reluctantly dropped a course after meeting with an adviser who thought I was struggling to acclimate to college. I was 850 miles from home and started to believe that I never should have left the East Coast. But Northwestern was the pennant on my corkboard at home; it was the sweatshirt my dad wore proudly to our local ...



Reported Pain and Fatigue Behaviors Mediate the Relationship Between Catastrophizing and Perceptions of Solicitousness in Patients with Chronic Fatigue

Sun, 29 Nov 2015 00:00:00 +0100

Catastrophizing is associated with negative outcomes in chronic pain and illness. The Communal Coping Model (CCM) and cognitive-behavioral (CB) formulations provide differing accounts of the function of catastrophizing in these contexts. The present study examined predictions from CCM and CB theoretical models in a sample of 116 patients with chronic fatigue to test: (1) whether patient-reported solicitous responses from significant others mediate the relationship of catastrophizing with patient-reported pain and fatigue behaviors, as predicted by the CCM, and (2) whether pain and fatigue behaviors mediate the relationship of catastrophizing with solicitous responses, consistent with a CB model. (Source: The Journal of Pain)