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MedWorm: Behcet's Disease



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Behcet's Disease category.



Last Build Date: Mon, 21 Mar 2016 20:00:53 +0100

 



Long-Term Efficacy of Adalimumab in Patients With Intestinal Behcet's Disease: Eight Consecutive Cases.

Fri, 18 Mar 2016 20:38:02 +0100

In conclusion, ADA offers an effective, well-tolerated treatment for intestinal BD in patients who are refractory to conventional therapy. PMID: 26985255 [PubMed] (Source: Clin Med Res)

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Higher Expression of NOD1 and NOD2 is Associated with Vogt-Koyanagi-Harada (VKH) Syndrome But Not Behcet's Disease (BD).

Wed, 16 Mar 2016 00:00:00 +0100

In conclusion, activation of NOD1 or NOD2 increased the production of pro-inflammatory cytokines in PBMCs and promoted the maturation and activation of human DCs in association with stimulation of Th1 and Th17 cells. Our results suggest that over-expression of NOD1 and NOD2 may be involved in the pathogenesis of VKH syndrome. PMID: 26980698 [PubMed - as supplied by publisher] (Source: Current Molecular Medicine)



Autoimmunity Including Intestinal Behcet Disease Bearing the KRAS Mutation in Lymphocytes: A Case Report

Tue, 01 Mar 2016 00:00:00 +0100

We experienced the case of a 3-year-old male with a very rare combination of autoimmunity, including immune thrombocytopenia, recurrent Henoch-Schönlein purpura and intestinal Behcet disease. Exome sequencing of the patient’s peripheral blood mononuclear cells identified a KRAS G13C mutation. Interestingly, the KRAS G13C mutation was observed in T and B lymphocytes, as well as natural killer cells, but not granulocytes. Our case was completely phenotypically different from RASopathies and did not meet the criteria for Ras-associated lymphoproliferative disease or juvenile myelomonocytic leukemia. This is the first reported case in which the KRAS mutation existed only in the lymphoid lineage. Based on the findings of our case and the current literature, it is clear that the RA...



Endovascular Treatment of A Ruptured Innominate Artery Aneurysm in Behcet Disease

Sun, 21 Feb 2016 00:00:00 +0100

We report a ruptured innominate artery aneurysm in a 70 year-old man with Behcet disease, which was successfully treated by innominate artery stent grafting through the right common carotid artery, axillo-axillary artery bypass grafting, and right subclavian artery coil embolization. (Source: Annals of Vascular Surgery)



Biotherapies in large vessel vasculitis

Thu, 18 Feb 2016 00:00:00 +0100

Publication date: Available online 12 February 2016 Source:Autoimmunity Reviews Author(s): Y. Ferfar, T. Mirault, A.C. Desbois, C. Comarmond, E. Messas, L. Savey, F. Domont, P. Cacoub, D. Saadoun Giant cell arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) and aortic involvement is not uncommon in Behcet's disease (BD) and relapsing polychondritis (RP). Glucocorticosteroids are the mainstay of therapy in LVV. However, a significant proportion of patients have glucocorticoid dependance, serious side effects or refractory disease to steroids and other immunosuppressive treatments such as cyclophosphamide, azathioprine, mycophenolate mofetil and methotrexate. Recent advances in the understanding of the pathogenesis have resulted in the use of biologica...



Meta-Analysis of Associations Between Interleukin-10 Polymorphisms and Susceptibility to Vasculitis.

Wed, 17 Feb 2016 14:24:02 +0100

CONCLUSIONS: This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD. PMID: 26213801 [PubMed - in process] (Source: Immunological Investigations)

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The role of statins in inflammatory vasculitides.

Wed, 17 Feb 2016 14:22:02 +0100

Authors: Tremoulet AH Abstract While the statins are best known for their cholesterol lowering capabilities, they also appear to have anti-inflammatory, anti-oxidant and endothelial-repairing properties that have raised the question as to whether this class of drugs can be of benefit in non-atherosclerotic, acute and chronic vasculitides. These effects, independent of the lipid-lowering effects, make the statins a class of drugs that are primed for repurposing and being used in disease states where innate and adaptive immunity and endothelial damage play a key role. Thus far, statins have been used in Behcet's, rheumatoid arthritis and Kawasaki disease with some promising results. Further study is needed to better understand the innate and adaptive immunological response to statins...



The Neutrophil-Lymphocyte Ratio and Behcet Disease

Tue, 16 Feb 2016 00:00:00 +0100

(Source: Angiology)



Biotherapies in large vessels vasculitis

Fri, 12 Feb 2016 00:00:00 +0100

Publication date: Available online 12 February 2016 Source:Autoimmunity Reviews Author(s): Y. Ferfar, T. Mirault, A.C. Desbois, C. Comarmond, E. Messas, L. Savey, F. Domont, P. Cacoub, D. Saadoun Giant cell arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LVV) and aortic involvement is not uncommon in Behcet's disease (BD) and relapsing polychondritis (RP). Glucorticosteroids are the mainstay of therapy in LVV. However, a significant proportion of patients have glucocorticoids dependance, serious side effects or refractory disease to steroids and other immunosuppressive treatments such as cyclophosphamide, azathioprine, mycophenolate mofetil and methotrexate. Recent advances in the understanding of the pathogenesis have resulted in the use of biological...






Comparison of Intravenous Morphine vs Paracetamol in Sciatica: A Randomized Placebo Controlled Trial

Mon, 01 Feb 2016 00:00:00 +0100

ConclusionMorphine and acetaminophen are both effective for treating sciatica at 30 minutes. However, morphine is superior to acetaminophen.This article is protected by copyright. All rights reserved. (Source: Academic Emergency Medicine)

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Inhibitory Effects of the Active Components Isolated from Satureja Boissieri Hausskn. Ex Boiss. On Human Cervical Cancer Cell Line

Tue, 26 Jan 2016 00:00:00 +0100

Abstract The aim of this study was to isolate the active components from the essential oil (EO) of Satureja boissieri and to investigate the cytotoxic effects of these components on human cervical epithelioid carcinoma (HeLa) cell line. The major components of EO were found to be p‐cymene (23.15%), γ‐terpinene (22.84%), thymol (18.96%) and carvacrol (21.25%) using GC‐MS. The components were separated by column chromatography and p‐cymene, thymol and spathulenol were isolated as pure terpenoids. The cytotoxic activity of the components was investigated using the xCELLigence system (Real Time Cell Analyzer). The pure compounds, p‐cymene and thymol exhibited excellent cytotoxic effects against HeLa cell line. Practical ApplicationsSatureja boissieri Hausskn. ex Boiss.(Lamiaceae) is...



Behcet's Disease: Is There Geographical Variation? A Review Far from the Silk Road.

Sun, 24 Jan 2016 11:33:02 +0100

Authors: Leonardo NM, McNeil J Abstract Behcet's Disease (BD) is a systemic vasculitis characterized by the triad of recurrent mouth and genital ulcers with eye involvement. To date there are no laboratory tests specific for the disease and diagnosis continues to remain on clinical grounds. Multiple criteria have been created as guides for diagnosis; however, given the wide spectrum of organ involvement, some cases remain undiagnosed. The diagnosis of Behcet's Disease may only be made over time as the clinical manifestations emerge sometimes separated by months and even years. With an increased recognition of this disease it has become apparent that there is geographical variation in clinical manifestations. In particular cardiac manifestations are not seen commonly in Caucasians c...



Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet's disease : A meta-analysis.

Fri, 22 Jan 2016 00:00:00 +0100

CONCLUSION: In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. PMID: 26800664 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)



Missed diagnosis of Behcet disease causing aortic regurgitation

Thu, 21 Jan 2016 00:00:00 +0100

Aortic regurgitation is a rare and serious presentation of Behcet’s disease. Here we describe a case of missed diagnosis of Behcet’s disease in a 37-year-old man, causing symptomatic aortic regurgitation. Perioperative diagnosis of Behcet’s aortitis is crucial because surgical intervention carries high reoperative morbidity and mortality. (Source: Asian Cardiovascular and Thoracic Annals)



Immunometabolic biomarkers of inflammation in Behçet's disease: Relationship with epidemiological profile, disease activity and therapeutic regimes.

Tue, 12 Jan 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. PMID: 26756979 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)

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Fatigue in patients with Behcet's syndrome: relationship with quality of life, depression, anxiety, disability and disease activity

Fri, 01 Jan 2016 00:00:00 +0100

ConclusionsFatigue is common in clinically active BS patients compared with healthy controls and inactive BS patients. Depression, anxiety and physical dysfunction were significantly associated with fatigue. (Source: APLAR Journal of Rheumatology)



Immunometabolic biomarkers of inflammation in Behçet's disease: Relationship with epidemiological profile, disease activity and therapeutic regimes

Fri, 01 Jan 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)



Cytomegalovirus infection inducing flare of Behcet's disease with possible recurrence of glomerulonephritis after renal transplantation

Wed, 30 Dec 2015 00:00:00 +0100

We present a case of young male with end-stage renal disease due to type III membranoproliferative glomerulonephritis (GN) and clinical features consistent with Behcet's disease (BD). He developed flare of BD 3 months after deceased donor renal transplantation following cytomegalovirus infection, in the form of oral and genital ulcers. He also had GN characterized by mild mesangial proliferation, neutrophilic infiltration and subepithelial, mesangial and intramembranous electron dense deposits, which could possibly be attributed to recurrence of renal disease due to BD. The clinical flare of BD was treated with colchicine with good response. (Source: Indian Journal of Nephrology)



Left ventricular mechanics in Behcet's disease: a speckle tracking echocardiographic study.

Sun, 20 Dec 2015 21:12:11 +0100

Authors: Demirelli S, Degirmenci H, Bilen H, Ermis E, Duman H, Arisoy A, Bakirci EM, Ipek E, Askin L Abstract Although cardiac involvement is rarely seen in Behcet's disease (BD), it is essential to detect subclinical left ventricular (LV) dysfunction for prognostic purposes. Herein we aimed to show the role of two dimensional (2D) speckle tracking echocardiography (STE) in determination of subclinical LV dysfunction in patients with BD. 30 patients diagnosed as BD due to International Study Group Behcet's diagnostic criteria and 25 control subjects underwent Doppler echocardiography including pulsed tissue Doppler of the mitral annulus and speckle-tracking echocardiography. LV peak longitudinal strain and strain rate (SR) was calculated in four-chamber (4C), apical long-axis (LAX)...



Emergency Quadrido-Bentall Procedure for Aortic Rupture in a Patient with Behcet's Disease.

Sat, 12 Dec 2015 06:21:42 +0100

We report the case of a patient with Behcet's disease presenting with contained aortic rupture around the aortic root. The patient had previously undergone aortic valve surgery three times due to recurrent prosthetic valve detachment. An emergency operation was performed, consisting of aortic root replacement (ARR) using a composite valved conduit and the replacement of the hemiarch. ARR may be an appropriate surgical option for patients with Behcet's disease in order to prevent recurrence of the disease. PMID: 26509132 [PubMed] (Source: Korean Journal of Thoracic and Cardiovascular Surgery)

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Behcet's disease in Acquired Immune Deficiency Syndrome

Fri, 11 Dec 2015 00:00:00 +0100

We present a case of an HIV/AIDS patient with recurrent orogenital aphthosis that was confirmed to have concomitant diagnosis of Behcet's disease. Proper awareness of the causes of these ulcers is essential for prompt and effective treatment. While rare causes may be at the bottom of a differential list in an immunocompetent host, when HIV/AIDS is involved these rare causes often percolate to the top. (Source: IDCases)



Association between red blood cell distribution width and disease activity in patients with Behcets disease

Wed, 09 Dec 2015 00:00:00 +0100

Conclusions RDW was increased in active disease compared with inactive disease. No relationships were found between organ involvement and RDW. RDW may be a cost-effective, novel potential parameter to evaluate disease activity in Behcet’s disease. (Source: Journal of International Medical Research)



Non-dipping blood pressure patterns and arterial stiffness parameters in patients with Behcet’s disease

Mon, 07 Dec 2015 00:00:00 +0100

Non-dipping blood pressure patterns and arterial stiffness parameters in patients with Behcet’s disease Hypertension Research 38, 856 (December 2015). doi:10.1038/hr.2015.86 Authors: Gulperi Celik, Sema Yilmaz & Serpil Ergulu Esmen (Source: Hypertension Research)



Tocilizumab in Severe and Refractory Behcet’s Disease: Four Cases and Literature Review

Tue, 01 Dec 2015 00:00:00 +0100

In Behcet's disease (BD), interleukin (IL)-6 drive the immune-mediated inflammatory process. The IL-6 receptor can be targeted using tocilizumab. As an off-label treatment we tested its efficacy in patients with BD. (Source: Seminars in Arthritis and Rheumatism)



Epidemiology of rheumatic diseases in Iran from analysis of four COPCORD studies

Tue, 01 Dec 2015 00:00:00 +0100

ConclusionCompared to other COPCORD reports (17 countries), Iran gets the following rank: musculoskeletal complaints second, low back pain fourth, osteoarthritis second, knee osteoarthritis third, soft tissue rheumatism sixth, rheumatoid arthritis tenth, seronegative spondyloarthropathies fifth, gout eleventh and fibromyalgia fifth. (Source: APLAR Journal of Rheumatology)

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Characteristics and long-term outcome of patients with noninfectious retinal vasculitis

Mon, 23 Nov 2015 19:49:47 +0100

Conclusion: A new systemic or ocular disease associated with retinal vasculitis was found in more than half of the patients. Behcet disease was the most common newly diagnosed disease. Specific diagnosis leading to proper management is important to maintain favorable long-term visual outcome. (Source: RETINA)



An unusual complication of Behcet disease: spontaneous bilateral pneumothorax

Thu, 19 Nov 2015 00:00:00 +0100

Behcet disease is a multisystem vasculitis of unknown etiology, and pulmonary involvement is unusual. Concurrent bilateral pneumothorax is also seen rarely. To the authors' knowledge, this is the first reported case of Behcet disease with concurrent bilateral pneumothorax in the literature. (Source: The American Journal of Emergency Medicine)



An unusual complication of Behcet's disease: Spontaneous bilateral pneumothorax

Thu, 19 Nov 2015 00:00:00 +0100

Behcet's Disease is a multisystem vasculitis of unknown etiology and pulmonary involvement is unusual. Concurrent bilateral pneumothorax is also seen rarely. To the authors' knowledge, this is the first reported case of Behcet's disease with concurrent bilateral pneumothorax in the literature. (Source: The American Journal of Emergency Medicine)



Anti-cardiolipin and anti-Neutrophil Cytoplasmic Antibodies in Iranian patients with Behcet's disease.

Wed, 18 Nov 2015 13:16:25 +0100

CONCLUSION: While anti-CL, anti-PR3 and anti-MPO IgG autoantibodies do not play a major role in susceptibility to BD or pathogenesis of vascular involvement in our patients, anti-CL Ab might be involved in skin lesion development in Iranian male BD patients. However, the results should be confirmed in other studies. PMID: 23268290 [PubMed - indexed for MEDLINE] (Source: Iranian Journal of Immunology)



High mobility group box 1 serum levels are increased in Behcet's disease, but not associated with disease activity or disease manifestations

Fri, 13 Nov 2015 00:00:00 +0100

Conclusion. Serum HMGB1 levels are increased in patients with BD as compared with healthy controls. However, no association was found with disease activity, specific organ involvement or therapy in BD. (Source: Rheumatology)

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Spontaneous Intra-Abdominal Hemorrhage Due to Rupture of Jejunal Artery Aneurysm in Behcet Disease: Case Report and Literature Review

Sun, 01 Nov 2015 05:00:00 +0100

We report a case of ruptured jejunal artery aneurysm in a 35-year-old patient with BD. The patient had a 1-year history of intermittent abdominal pain caused by superior mesenteric artery aneurysm with thrombosis. Anticoagulation treatment showed a good response. Past surgical history included stenting for aortic pseudoaneurysm. On admission, the patient underwent an urgent operation due to sudden hemorrhagic shock. Resection was performed for jejunal artery aneurysm and partial ischemia of intestine. The patient was diagnosed with BD, based on a history of recurrent oral and skin lesions over the past 6 years. Treatment with anti-inflammatory medications showed a good response during the 8-month follow-up. An increased awareness of BD and its vascular complications is essential. Aneurysms...



Clinical and Ultrasonographic Evaluation of Lower-extremity Vein Thrombosis in Behcet Syndrome: An Observational Study

Sun, 01 Nov 2015 05:00:00 +0100

Abstract: Vascular involvement can be seen in up to 40% of patients with Behcet syndrome (BS), the lower-extremity vein thrombosis (LEVT) being the most common type. The aim of the current study was to compare venous Doppler findings and clinical features between BS patients with LEVT and control patients diagnosed as having LEVT due to other causes. All consecutive 78 patients (71 men, 7 women; mean age 38.6 ± 10.3 years) with LEVT due to BS and 50 control patients (29 men, 21 women; mean age 42.0 ± 12.5 years) who had LEVT due to other causes, or idiopathic, were studied with the help of a Doppler ultrasonography after a detailed clinical examination. Patterns of venous disease were identified by cluster analyses. Clinical features of chronic venous disease were assessed using ...



Hughes-Stovin syndrome: A case report

Fri, 30 Oct 2015 00:00:00 +0100

Conclusion: HSS is a rare type of vasculitis. Less than 50 cases has been published in the literature, with most of the patients being young males aged from 20 to 40 years. Our patient is an example that HSS can be diagnosed in the elderly, although the symptoms had started much earlierThe management of HSS includes both medical (immunosuppressives) and surgical (resection, embolization) options. However, massive pulmonary bleeding remains the most common cause of the death in those patients. (Source: European Respiratory Journal)



Tuberculosis in patients receiving treatment of TNF-alpha inhibitors

Fri, 30 Oct 2015 00:00:00 +0100

Conclusion: The TB risk is increased in patients who use TNF alpha inhibitor therapy, and majority of them are extrapulmonary tuberculosis. The clinicians must be careful in terms of extrapulmonary tuberculosis in these patients. (Source: European Respiratory Journal)



Restarting biologic agents in rheumatology patients who developed tuberculosis under TNF{alpha}-inhibitor treatment

Fri, 30 Oct 2015 00:00:00 +0100

Conclusion: Biologic agents including TNF-αI,can be restarted in patients who had previously developed Tb under anti-TNF treatment.Careful follow-up for TB relapse is required. (Source: European Respiratory Journal)

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Durability of aneurysm treatments in patients with active Behcet's disease.

Thu, 29 Oct 2015 00:00:00 +0100

CONCLUSION: Although early results were good, intermediate ones were not satisfactory because of progressive graft thrombosis and formation of new aneurysms. Awareness of these rare cases help for early identification and proper immunosuppressive before emergency vascular intervention is warranted. PMID: 26519256 [PubMed - as supplied by publisher] (Source: Vascular)






Putative Role of Serum Amyloid-A and Proinflammatory Cytokines as Biomarkers for Behcet's Disease

Thu, 01 Oct 2015 05:00:00 +0100

Abstract: Behcet's disease (BD) is a multisystemic disorder of unknown etiology characterized by relapsing oral–genital ulcers, uveitis, and involvement of vascular, gastrointestinal, neurological, and musculoskeletal system. Although disease pathogenesis is still unclear, both innate and adaptive immunity have shown to play a pivotal role, and multiple proinflammatory cytokines seem to be involved in different pathogenic pathways that eventually lead to tissue damage. The aims of our study were to evaluate serum cytokines levels of IL-8, IL-18, IFN-α2a, IL-6, IFN-γ, CXCL10, CXCL11, CXCL9, and SAA levels in patients with BD, in comparison to healthy controls (HC), and to correlate their levels to disease activity. We included 78 serum samples obtained from 58 BD patients and analyzed a...



Outcomes for Women with Rare Autoimmune Diseases

Thu, 01 Oct 2015 00:00:00 +0100

Conclusions: While the majority of women with rare autoimmune diseases delivered healthy infants, they were at increased risk of having both maternal complications and adverse neonatal outcomes suggesting their pregnancies should be closely monitored. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)



Spontaneous reports of vasculitis as an adverse event following immunization: A descriptive analysis across three international databases.

Fri, 18 Sep 2015 00:00:00 +0100

CONCLUSION: Similar reporting patterns of vasculitides were observed in different databases. Implementation of standardized case definitions for specific vasculitides could improve overall data quality and comparability of reports. PMID: 26392009 [PubMed - as supplied by publisher] (Source: Vaccine)

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'Behcet's disease can now be treated with homeopathy'

Mon, 14 Sep 2015 13:03:48 +0100

Behcet's disease, one of the rarest immunological disorders where a patient suffers serious ulcerations in mouth and genitals, can now be treated with homeopathy. (Source: The Economic Times)



TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.

Sat, 12 Sep 2015 00:00:00 +0100

In this study, to elucidate the function of TRIM39 in inflammatory signaling, we performed yeast two-hybrid screening using TRIM39 as a bait and identified Cactin, which has been reported to inhibit NFκB- and TLR-mediated transcriptions. We show that TRIM39 stabilizes Cactin protein and that Cactin is upregulated after TNFα stimulation. TRIM39 knockdown also causes activation of the NFκB signal. These findings suggest that TRIM39 negatively regulates the NFκB signal in collaboration with Cactin induced by inflammatory stimulants such as TNFα. PMID: 26363554 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Life Sciences : CMLS)



Pulmonary manifestations in a group of patients with Behcet's disease

Wed, 09 Sep 2015 00:00:00 +0100

ConclusionThe higher frequency of pulmonary manifestations in our patients (73.3%) and the higher frequency of PAA (33.3%) could be related to the fact that this study was conducted on a group of patients who were admitted to the hospital with more severe illnesses. (Source: APLAR Journal of Rheumatology)



Cross-cultural adaptation and validation of the Behcet's Disease Current Activity Form in Korea.

Tue, 01 Sep 2015 00:00:00 +0100

CONCLUSIONS: The Korean version of the BDCAF is a reliable and valid instrument for measuring current disease activity in Korean BD patients. PMID: 26354066 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)



P.1.f.008 In vivo, in vitro and behavioural effects of intracerebral injection of neuro-Behcet's disease immunoglobulin and sera to brain parenchyma

Tue, 01 Sep 2015 00:00:00 +0100

(Source: European Neuropsychopharmacology)

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The Effect of Colchicine on Mean Platelet Volume in Behcet's Disease.

Tue, 01 Sep 2015 00:00:00 +0100

CONCLUSIONS: Given the proposed relationship between MPV and platelet activity, MPV may serve as a surrogate essay for Behcet's response to colchicine. Colchicine might suppress platelet function and be used in vascular involvement together with immunosuppressant agents in Behcet's Disease. Further studies in large population are needed to evaluate the role of colchicine in platelet function and the effect of colchicine on thrombosis in BD. PMID: 26586706 [PubMed - in process] (Source: Annals of Clinical and Laboratory Science)



Behcet Disease Presenting With Cardiac and Pulmonary Masses

Sat, 29 Aug 2015 00:00:00 +0100

We present a case of Behcet disease, presenting with enhancing cardiac and pulmonary inflammatory masses that mimicked the imaging appearance of metastatic cardiac angiosarcoma. Subsequent magnetic resonance imaging examination showed the mass reduced in size with immunosuppressive therapy. This case highlights the importance of considering Behcet disease in the differential diagnosis for an enhancing cardiac mass. (Source: Canadian Journal of Cardiology)



Aortic thrombosis in a patient with a late diagnosis of Behcet's disease

Wed, 26 Aug 2015 13:56:04 +0100

We describe the case of a patient with Thromboangiitis Obliterans who was treated with lumbar sympathectomy and an aortobiiliac bypass. Around 1 year later he was diagnosed with Behcet's disease after presenting with oral ulcers, genital ulcers and scaling lesions on the hands.A Doença de Behçet é uma vasculite sistêmica de etiologia desconhecida. O inusitado é que o acometimento arterial nesta doença é menos comum que o venoso, correspondendo a 1 a 7% dos pacientes. Já os sintomas vasculares precedem o diagnóstico clínico de Behçet em 7 a 30%. Relatamos o caso de um paciente portador de Tromboangeíte Obliterante que foi submetido a simpatectomia lombar e derivação aorto-bi-ilíaca. Após cerca de um ano, diagnosticou-se Doença de Behçet, devido a quadro clínico de úlcera...



Mucocutaneous pyoderma gangraenosum due to trisomy 8 neutrophilic infiltrates in a patient with myelodysplastic syndrome

Mon, 24 Aug 2015 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)



Mucocutaneous pyoderma gangraenosum due to trisomy 8 neutrophilic infiltrates in a patient with myelodysplastic syndrome.

Mon, 24 Aug 2015 00:00:00 +0100

This article is protected by copyright. All rights reserved. PMID: 26301955 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

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Zoledronic acid-induced hepatotoxicity relieved after subsequent infusions in a Chinese woman with glucocorticoid-induced osteoporosis

Sat, 22 Aug 2015 00:00:00 +0100

Conclusions Hepatotoxicity due to ZOL therapy is a rare, but possible adverse effect which may be relieved after subsequent infusions. (Source: European Journal of Medical Research)



Do altitude and climate affect paranasal sinus volume?

Tue, 18 Aug 2015 00:00:00 +0100

Conclusion There have been many studies of nasal cavity changes due to climatic conditions but this is the first study to measure the difference of paranasal sinus volumes. No difference was determined in the anatomic variations and volumes of the maxillary, frontal, sphenoid sinuses on PNSCT of patients from different climates and altitudes. (Source: Journal of Cranio Maxillofacial Surgery)



Ovarian reserve alterations in premenopausal women with chronic inflammatory rheumatic diseases: impact of rheumatoid arthritis, Behcet's disease and spondyloarthritis on anti-Mullerian hormone levels

Fri, 14 Aug 2015 00:00:00 +0100

Conclusion. This is the first study to show a reduced ovarian reserve in patients with RA, SpA or BD. Together with our findings in SLE, we conclude a negative influence of chronic rheumatic diseases on ovarian reserve. (Source: Rheumatology)



Adult Behcet's disease in Iran: analysis of 6075 patients

Mon, 10 Aug 2015 00:00:00 +0100

ConclusionResults are near the nationwide surveys from Japan, China, Korea and Germany. (Source: APLAR Journal of Rheumatology)



Venous thromboembolism in systemic autoimmune diseases: A narrative review with emphasis on primary systemic vasculitides

Fri, 07 Aug 2015 00:00:00 +0100

Venous thromboembolism (VTE) is a prevalent multifactorial health condition associated with significant morbidity and mortality. Population-based epidemiological studies have revealed an association between systemic autoimmune diseases and deep venous thrombosis (DVT)/VTE. The etiopathogenesis of increased risk of VTE in systemic autoimmune diseases is not entirely clear but multiple contributors have been explored, especially in the context of systemic inflammation and disordered thrombogenesis. Epidemiologic data on increased risk of VTE in patients with primary systemic vasculitides (PSV) have accumulated in recent years and some of these studies suggest the increased risk while patients have active diseases. This could lead us to hypothesize that venous vascular inflammation has a role...

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Behcet's disease without oral ulcers presenting with erythema nodosum and deep venous thrombosis.

Mon, 27 Jul 2015 00:00:00 +0100

We present a young male with recurrent erythema nodosum and recent deep vein thrombosis with scrotal ulcers but no oral ulcers. He was diagnosed as having Behcet's disease (BD) and subsequently responded to immunosuppressants and anticoagulation. This case highlights that up to 2% patients with BD may not have oral ulcers. Timely institution of therapy in our patient resulted in a favorable outcome. PMID: 26220926 [PubMed - as supplied by publisher] (Source: Tropical Doctor)



Already with $1 billion in losses, Xoma plummets with late-stage drug failure

Fri, 24 Jul 2015 20:27:47 +0100

Xoma Corp. continued tumbling Friday after its headline drug failed a late-stage clinical trial in patients with a blinding eye disease. Berkeley-based Xoma's (NASDAQ: XOMA) stock closed at 94 cents per share Friday, down nearly 9 cents from the previous close. From a Tuesday close of $4.39, the stock had fallen as low as 85 cents on Wednesday's news of the drug's failure in a study of patients with Behcet's uveitis, a potentially blinding chronic inflammation of blood vessels in the eye. The drug,… (Source: bizjournals.com Health Care:Hospitals headlines)



Anti-IL-1 Drugs Safe, Effective in Behcet's Disease (CME/CE)

Fri, 24 Jul 2015 17:00:00 +0100

(MedPage Today) -- The rare inflammatory condition responds to anti-interleukin agents, researchers concluded. (Source: MedPage Today Rheumatology)



Neutrophil-Lymphocyte Ratio in Behcet Disease

Fri, 24 Jul 2015 00:00:00 +0100

(Source: Angiology)

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No association between Bach2 gene polymorphisms with Vogt-Koyanagi-Harada syndrome (VKH) and Behcet's disease (BD) in a Chinese Han population

Tue, 21 Jul 2015 00:00:00 +0100

Conclusions The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either VKH or BD in our investigated Chinese Han population. Clinical trial registry This project was registered in the Chinese Clinical Trial Registry (registration number: ChiCTR-CCC-12002184). (Source: British Journal of Ophthalmology)



Associations between major histocompatibility complex class I chain-related gene A polymorphisms and susceptibility to Behcet's disease : A meta-analysis.

Sat, 18 Jul 2015 00:00:00 +0100

CONCLUSION: This meta-analysis shows that the MICA-TM A6 allele and the MICA*009 allele are associated with BD susceptibility in various ethnic populations, and that MICA alleles are in strong linkage disequilibrium with HLA-B51 in BD. PMID: 26184953 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Rheumatologie)



CRDC: a Chinese rheumatology research platform

Sat, 11 Jul 2015 00:00:00 +0100

Abstract This review introduces the history of development, organizational structure, funding resources, data collection, and quality control of the Chinese Rheumatism Data Center (CRDC) and summarizes the collection of data. In 2009, Peking Union Medical College Hospital (PUMCH), together with several rheumatism centers, established the Chinese Systemic Lupus Erythematosus (SLE) Treatment and Research Group (CSTAR) to collect data on Chinese patients for the study of SLE disease characteristics. In 2011, CSTAR was extended with the formation of the CRDC at PUMCH with direction from the National Health and Family Planning Commission of the PRC. The CRDC currently includes 300 registration sites and 50 regional sites that have successively begun to collect data on 12 rheumatic dise...



Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

Fri, 03 Jul 2015 00:00:00 +0100

To evaluate subclinical atherosclerosis in Behcet disease (BD), we performed a systematic review and meta-analysis of studies where atherosclerosis was determined by flow-mediated dilatation (FMD) and endothelial-mediated dilatation (EMD) and by measurement of intima media thickness (IMT) of carotid arteries. (Source: Seminars in Arthritis and Rheumatism)






[Multiple small bowel perforations due to Behcet's disease].

Wed, 01 Jul 2015 00:00:00 +0100

This study aimed to report multiple ileum perforations as an unusual complication of Behcet's disease at the time of presentation and review of the current literature of reported cases. PMID: 26374419 [PubMed - in process] (Source: Turkish Journal of Trauma and Emergency Surgery : TJTES)



Anakinra treatment in drug-resistant Behcet’s disease: a case series

Mon, 22 Jun 2015 16:31:50 +0100

Abstract The study objective was to report treatment with an interleukin (IL)-1 receptor antagonist, anakinra, in patients with multiorgan Behcet's disease (BD). Comparison of clinical manifestations, previous treatments, markers of inflammation, concomitant medications, treatment regimen modifications, relapses, and adverse events before and during anakinra administration among patients with BD were evaluated. Nine BD patients (mean age 34.55 ± 16.30 years) refractory to tumor necrosis factor blockers and standardized therapies are reported in our survey. Their mean age at disease onset was 25 ± 13.88 years and their overall disease duration was 9.55 ± 5.33 years. All patients were positive for the HLA-B51 allele. Within 1 or 2 weeks following the initiation o...






Aortoiliac Thrombosis in Behcet's Disease: A Case Report

Sat, 13 Jun 2015 17:06:48 +0100

We describe a case of Behcet's disease in a 33 year-old woman who presented with rest pain in the foot and toe ulceration. Arterial imaging demonstrated multilevel occlusive lesions involving the infrarenal aorta, common iliac artery, and tibial and peroneal arteries. (Source: Annals of Vascular Surgery)



Ocular Inflammation in the Setting of Concomitant Systemic Autoimmune Conditions in an Older Male Population

Wed, 10 Jun 2015 14:31:54 +0100

Conclusions: In this population, ocular manifestations were rarely the presenting feature of systemic disease, but autoimmune disorders are an important underlying cause of inflammatory eye disease that should be considered on first evaluation, even in this “nontraditional,” predominantly male, autoimmune disease population. (Source: Cornea)

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Chicken or the egg: the dilemma of allergic rhinitis versus adenoid hypertrophy.

Thu, 04 Jun 2015 04:54:04 +0100

CONCLUSION: In this study, AH and AR were inversely related. The characteristics of the nasal secretions, itching, sneezing, were predictors of AR in children. PMID: 26030038 [PubMed - in process] (Source: Rhinology)



Prospective study of articular manifestations in Behçet's disease: five‐year report

Mon, 01 Jun 2015 00:00:00 +0100

ConclusionMusculoskeletal involvement is a common manifestation of BD seen in more than half of patients. Acute knee monoarthritis was the most common pattern of articular involvement in BD. (Source: APLAR Journal of Rheumatology)



Th22 Cells Contribution in Immunopathogenesis of Rheumatic Diseases.

Mon, 01 Jun 2015 00:00:00 +0100

Authors: Azizi G, Simhag A, M-M-El Rouby N, Mirshafiey A Abstract Newly identified T helper cell 22 (Th22) is a subset of CD4+T cells with specific properties apart from other known CD4+ T cell subsets with distinguished gene expression and function. Th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (IL)-22, IL-13, and tumor necrosis factor-α (TNF-α). The levels of Th22 and related cytokine IL-22 are increased in various autoimmune diseases and positively associated with some rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, behcet's disease, ankylosing spondylitis and psoriatic arthritis. In summary, IL-22 and Th22 cells play a significant and complicated role in inflammatory and autoi...



Hippocrates’ Contributions to Dermatology

Mon, 01 Jun 2015 00:00:00 +0100

Although dermatology did not become a medical subspecialty until the end of the 18th century, many concepts regarding dermatological diseases remain as fresh today as when they were first described over 2000 years ago. In the third century bc, the Hippocratic Collection, also known as the Corpus Hippocraticum, gave information about the anatomy and physiology of the skin (eg, the role of perspiration in maintaining homeostasis) and described skin conditions throughout the collection because they were regarded as cutaneous manifestations of systemic diseases. For example, Hippocrates noted that clubbed fingernails are associated with underlying pulmonary disease, and that urticaria associated with swollen joints and diarrhea may indicate a worm infestation. Hippocrates also described an ass...



Do altitude and climate affect paranasal sinus volume?

Mon, 01 Jun 2015 00:00:00 +0100

The aim of this study was to evaluate the effect of climate and altitude differences on the volume of paranasal sinuses and on the frequency of anatomic variations by comparing the paranasal sinus tomograms (PNSCT) of patients who were born and living in a cold, dry climate at high altitude with those of patients who were born and living on the coast at sea level in a temperate climate. We also aimed to determine differences relating to gender. (Source: Journal of Cranio-Maxillofacial Surgery)

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Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population.

Sun, 31 May 2015 01:10:04 +0100

CONCLUSIONS: The findings showed that IL-10 is a risk gene for BD but not for VKH syndrome. PMID: 26015771 [PubMed - in process] (Source: Molecular Vision)



Ruptured Carotid Aneurysm Revealing a Behcet's Disease

Sat, 30 May 2015 00:00:00 +0100

We report the case of a 20-year-old male who was operated for a large ruptured aneurysm of the right common carotid artery, revealing a Behcet's disease. The aneurysm was excised and the right common carotid artery was repaired with a polytetrafluoroethylene prosthesis. None of the criteria of the International Study Group for Behcet's disease was present at the time of the diagnosis. (Source: Annals of Vascular Surgery)



Behcet's disease and refractory thrombosis

Thu, 28 May 2015 00:00:00 +0100

(Source: QJM)



Behcet Colitis

Mon, 25 May 2015 00:00:00 +0100

Clinics in Colon and Rectal Surgery 2015; 28: 099-102DOI: 10.1055/s-0035-1547336Behcet disease (BD) is a chronic, multisystem, inflammatory disease characterized by variable clinical manifestations involving systemic vasculitis of both the small and large blood vessels. The majority of BD patients present with recurrent oral ulcers in combination with other manifestations of the disease, including genital ulcers, skin lesions, arthritis, uveitis, thrombophlebitis, gastrointestinal or central nervous system involvement. Gastrointestinal BD occurs in 3 to 25% of the BD patients and shares many clinical characteristics with inflammatory bowel disease (IBD). Consequently, the differentiation between IBD and gastrointestinal manifestation of BD is very difficult. Intestinal BD should be conside...



Epidemiology of vasculitis – Lessons learnt from the differences in different geographical areas

Thu, 21 May 2015 00:00:00 +0100

Publication date: Available online 21 May 2015 Source:Indian Journal of Rheumatology Author(s): Richard A. Watts The epidemiology of the vasculitides has been increasingly investigated over the past 30 years and we have now gathered significant knowledge about the occurrence of vasculitis in many populations. There is however still a lack of reliable data from the Indian subcontinent. For most types of vasculitis it is not known if differences in occurrence represent variation in genes, environment, or ascertainment. Giant cell arteritis is most common in populations of Northern Europe or Scandinavian origin and is rarer in the far East, whilst Takayasu arteritis is apparently commoner in Asia. The ANCA vasculitides have an overall occurrence that is similar in most populations, but in C...

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An isolated left ventricular septal aneurysm in Behcet's disease

Wed, 20 May 2015 00:00:00 +0100

(Source: European Journal of Echocardiography)



Pegylated interferon-{alpha}-2b reduces corticosteroid requirement in patients with Behcet's disease with upregulation of circulating regulatory T cells and reduction of Th17

Fri, 08 May 2015 00:00:00 +0100

Conclusions The addition of peginterferon-α-2b to the drug regime of BD patients did not significantly reduce their corticosteroid dose required at 1 year. However, in those on corticosteroids at baseline post hoc analysis demonstrated that the addition of peginterferon-α-2b did result in a significant reduction in corticosteroid dose with a significantly improved quality of life and trend to reduce other required immunosuppressive agents. This effect was seen at 1 year and associated with a rise in Tregs suggesting a possible mode for interferon action. Trial registration number ISRCTN 36354474; EudraCT 2004-004301-18. (Source: Annals of the Rheumatic Diseases)



Homonymous hemianopia in a patient with Behcet's disease.

Fri, 01 May 2015 00:00:00 +0100

Authors: Lee WS, Kang MH, Jung WS, Cheon YH, Yoo WH PMID: 25995676 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)



Heterogeneous Nuclear Ribonucleoprotein A2/B1 as a Target Antigen in Han Chinese for BD Patients.

Tue, 28 Apr 2015 00:00:00 +0100

In this study, the target 35 kDa recombinant human hnRNP A2/B1 were over-expressed and purified, then sequenced with MALDI-TOF-TOF mass spectrometry. Western blotting and ELISA were applied to detect serum reactivity against hnRNP A2/B1 respectively. The results demonstrate that hnRNP A2/B1 is an autoantigen of BD in Han Chinese population. PMID: 25925770 [PubMed - as supplied by publisher] (Source: Protein and Peptide Letters)

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ERAP1 polymorphism relevant to inflammatory disease shapes the peptidome of the birdshot chorioretinopathy-associated HLA-A*29:02 antigen.

Sun, 19 Apr 2015 00:00:00 +0100

In this study, comparative immunopeptidomics was used to characterize >5000 A*29:02 ligands and quantify the effects of ERAP1 polymorphism and expression on the A*29:02 peptidome in human cells. The peptides predominant in an active ERAP1 context showed a higher frequency of nonamers, and bulkier amino acid side chains at multiple positions, compared to the peptides predominant in a less active ERAP1 background. Thus, ERAP1 polymorphism has a large influence, shaping the A*29:02 peptidome through length-dependent and length-independent effects. These changes resulted in increased affinity and hydrophobicity of A*29:02 ligands in an active ERAP1 context. The results reveal the nature of the functional interaction between A*29:02 and ERAP1 and suggest that this enzyme may affect the susce...



Association analysis of TGFBR3 gene with Behcet's disease and idiopathic intermediate uveitis in a Caucasian population

Fri, 17 Apr 2015 00:00:00 +0100

Conclusions RS1805110 is not associated with BD or IIU in Caucasian patients. The T allele frequency is consistent with that presented for Caucasian populations in the HapMap database (p>0.05). Our results differ from the previous analysis in Han Chinese patients (p<0.0001), however, the possibility of having a much smaller effect due to the low minority frequency cannot be excluded. (Source: British Journal of Ophthalmology)



The saga of diagnostic/classification criteria in Behcet's disease

Thu, 16 Apr 2015 00:00:00 +0100

Abstract There are 17 sets of diagnosis/classification criteria for Behcet's disease: Curth (1946), Hewitt (1969), Mason (1971), Japan (1972), Hubault (1974), O'Duffy (1974), Cheng (1980), Dilsen (1986), Japan revised criteria (1988), International Study Group on Behcet's disease (ISG criteria, 1990), Iran traditional criteria (1993), Iran Classification Tree (1993), Dilsen revised criteria (2000), Korea Criteria (2003), International Criteria for Behcet's Disease (ICBD, 2006) and the revised ICBD (2010). This review is intended to show how to use them and show their performance in patients from different parts of the world. The major sets of patients (patient numbers, control numbers, year) on which the criteria were tested are: ISG set (886/97/1990), Iran (2069/1540/1993), Asia and Pacif...



No association between Bach2 gene polymorphisms with Vogt-Koyanagi-Harada syndrome (VKH) and Behcet's disease (BD) in a Chinese Han population.

Tue, 14 Apr 2015 00:00:00 +0100

CONCLUSIONS: The investigated Bach2 gene polymorphisms (rs11755527, rs3757247, rs12212193 and rs2474619) are not related to the susceptibility to either VKH or BD in our investigated Chinese Han population. CLINICAL TRIAL REGISTRY: This project was registered in the Chinese Clinical Trial Registry (registration number: ChiCTR-CCC-12002184). PMID: 25873652 [PubMed - as supplied by publisher] (Source: The British Journal of Ophthalmology)



Behcet's disease diagnosed after acute HIV infection: viral replication activating underlying autoimmunity?

Mon, 13 Apr 2015 00:00:00 +0100

We describe a patient who presented with systemic vasculitis with skin and mucous membrane ulcerations in the setting of acute HIV infection, who was eventually diagnosed with Behçet’s disease, demonstrating a possible link between acute HIV infection, immune activation and development of autoimmunity. (Source: International Journal of STD and AIDS)

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Levels of F2 isoprostane in Behcet's disease: Correlation with cardiometabolic risk factors.

Mon, 13 Apr 2015 00:00:00 +0100

Conclusion High levels of F2 isoprostane in patients with BD indicate oxidative stress. Antioxidant therapeutic approaches could potentially affect the course of this disease. PMID: 25867971 [PubMed - as supplied by publisher] (Source: Redox Report : communications in free radical research)



Neuro-Behcet's Syndrome:Case Reports Emphasizing Challenges of Early Diagnosis (P2.075)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: In both cases, NBS was ultimately diagnosed based on characteristic MRI findings, particularly fluctuating brain stem-diencephalic involvement, superimposed on supportive clinical and CSF profiles. Challenges to early diagnosis are highlighted by our cases and by the literature. The differential diagnosis is often broad at onset. Mucocutaenous symptoms can be a clue but may not be present. Awareness of NBS and its neuroimaging correlates is critical to enable timely diagnosis, particularly given that this condition can favorably respond to steroids and steroid-sparing agents.Disclosure: Dr. Feldman has nothing to disclose. (Source: Neurology)



A Case of Neuro-Behcet's Disease Presenting With Central Neurogenic Hyperventilation (P2.076)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: This case is remarkable for several reasons: (1) Our patient had an oral ulceration but this came late in the course and only after her other neurological symptoms; (2) She did not have genital ulcerations, skin lesions, or skin pathergy; (3) Uveitis is the most frequent ocular manifestation of Behcet’s disease. Retinal detachment has been well described but it is uncommon; (4) Neuro-Behcet’s disease is rare occurring in 10-20[percnt] of patients with Behcet’s disease. Typically this develops many years after the diagnosis of Behcet’s; (5) The most common presentation of Neuro-Behcet’s disease is a meningoencephalitis followed by venous thrombosis. While venulitis is typical for Behcet’s disease, still this is uncommon; (6) To our knowledge,...



Intracranial Germinoma Associated Rubral Tremor Mimicking Neuro-Behcet Disease: Importance of a tissue diagnosis (P3.012)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: Delayed-onset rubral tremor should prompt a lesional evaluation. If diagnostic uncertainty remains following non-invasive testing, intracranial biopsy can be safely pursued. Steroid responsiveness can be seen in non-inflammatory pathology including neoplasms (i.e. lymphoma, germinoma). Prompt evaluation and appropriate treatment are important as Holmes tremor responds poorly to symptomatic therapies and response to RT is favorable for germinomas.Disclosure: Dr. Strowd has nothing to disclose. Dr. Burger has nothing to disclose. Dr. Holdhoff has nothing to disclose. Dr. Kleinberg has nothing to disclose. Dr. Olivi has nothing to disclose. Dr. Pardo-Villamizar has nothing to disclose. Dr. Okun has received royalty payments from Demos, Humana, Amazon, Smashwords, Books4Patients, ...



Serum antibodies isolated from neuro-Behcet's disease patients mediate neuronal death and cognitive impairment (P4.060)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: Although NBD lesions are generally located in the brainstem, most NBD patients develop cognitive dysfunction. Our findings indicate that NBD IgG is capable of inducing proinflammatory changes, neuronal death and cognitive impairment, suggesting that parenchymal NBD is not caused exclusively by the cytotoxic effects of infiltrating immune cells and anti-neuronal antibodies might have a negative impact on disease course.Disclosure: Dr. Tuzun has nothing to disclose. Dr. Erdag has nothing to disclose. Dr. Sahin has nothing to disclose. Dr. Kucukali has nothing to disclose. Dr. Kaya has nothing to disclose. Dr. Kurtuncu has nothing to disclose. Dr. Turkoglu has nothing to disclose. Dr. Aricioglu has nothing to disclose. (Source: Neurology)

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A Rare Presentation of Neuro-Behcet's Disease (NBD) (P4.062)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: We present a rare manifestation of BD in which our patient had rapidly progressive spinal cord lesions. High dose steroids are the initial choice in management, but the optimal management for chronic NBD has yet to be determined. Immunosuppresion is thought to be the best treatment guided by the severity of systemic symptoms. Spinal involvement has a less favorable response to therapy, highlighting the importance of early recognition and aggressive treatment.Disclosure: Dr. Harris has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Urtecho has nothing to disclose. Dr. Bell has nothing to disclose. (Source: Neurology)



Magnetic Resonance Neurography in the Diagnosis of Noncompressive Lumbosacral Radiculoplexus Neuropathies (P5.078)

Wed, 08 Apr 2015 00:00:00 +0100

Conclusion: MRN is an important tool that can help localize and diagnose LSRP caused by a variety of conditions. Clinicians and neuroradiologists should be aware of the differential diagnosis for noncompressive LSRP and the spectrum of radiographic findings. Future studies should determine the optimized operating characteristics and psychometrics of MRN in the diagnosis of LSRP.Disclosure: Dr. Robbins has nothing to disclose. Dr. Benedetti has nothing to disclose. Dr. Scott has nothing to disclose. Dr. Chin has nothing to disclose. Dr. Douglas has received personal compensation for activities with Grifols as a speaker. (Source: Neurology)



Evaluation of Correlations between Cerebral MRI Volumes, Retinal Thickness, Cognitive Involvement and Clinical Features in Parenchymal Neuro-Behcet Patients (P7.020)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS; Cognitive performance of PNB group was worse than the other groups in spite of mild disability scores; mainly memory processes were affected; VEP latency and amplitude values were strongly correlated with hemispheric white matter volume loss. Despite mild disability in PNB group, brainstem and diencephalon atrophy was detected. However, probably due to low number of patients there was no correlation between cognitive findings and MRI, VEP and OCT parameters.Disclosure: Dr. Gündüz has nothing to disclose. Dr. Kurtuncu has nothing to disclose. Dr. Matur has nothing to disclose. Dr. Topcular has nothing to disclose. Dr. Bilgic has nothing to disclose. Dr. Limon has nothing to disclose. Dr. Tanyildiz has nothing to disclose. Dr. Izgi has nothing to disclose. Dr. Erdogan ...



Bilateral pulmonary artery aneurysm in Behcet's disease

Wed, 18 Mar 2015 00:00:00 +0100

Publication date: Available online 18 March 2015 Source:Indian Journal of Rheumatology Author(s): Yathish G.C. , Canchi Balakrishnan , Taral Parikh , Neha Sawant (Source: Indian Journal of Rheumatology)



Dr. Hulusi Behcet

Thu, 05 Mar 2015 00:00:00 +0100

Publication date: March 2015 Source:Indian Journal of Rheumatology, Volume 10, Issue 1 Author(s): V.R. Joshi , V.B. Poojary (Source: Indian Journal of Rheumatology)

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