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MedWorm: Asbestosis



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Asbestosis category.



Last Build Date: Tue, 22 Mar 2016 08:28:07 +0100

 



MiR-595 targeting regulation of SOX7 expression promoted cell proliferation of human glioblastoma

Mon, 21 Mar 2016 00:00:00 +0100

Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): Yu Hao, Shubao Zhang, Shaojun Sun, Jianxin Zhu, Yilei Xiao Increasing evidence indicated that dysregulation of microRNAs (miRNAs) were involved with human disease including cancer. Recently, miR-595 was reported as a tumor promoter in malignant mesothelioma. However, the underlying mechanism of miR-595 in human glioblastoma (GBM) cells have not been well elucidated. Therefore, in this study, we investigated the biological functions and molecular mechanisms of miR-595 in human GBM. MiR-595 expression was significantly upregulated in GBM tissues and cells. We modified miR-595 levels in GBM cells and investigated their effects on the cell proliferation by MTT, colony formation and anchorage-in...

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Histopathology of removed indwelling pleural catheters from patients with malignant pleural diseases

Sat, 19 Mar 2016 00:00:00 +0100

ConclusionOur study provides reassuring evidence that the IPC material does not support direct tumour growth or invasion even in the setting of high mesothelioma prevalence. (Source: Respirology)



Garlock, EnPro Reach $480M Settlement for Asbestos Claims

Fri, 18 Mar 2016 20:12:35 +0100

EnPro Industries has agreed to establish a $480 million trust fund to settle all current and future asbestos claims against subsidiary Garlock Sealing Technologies, which filed for bankruptcy in 2010. The asbestos trust fund would begin with a $400 million cash contribution from EnPro within a year of the deal’s conclusion and an additional $80 million by the first anniversary. The settlement was reached with the court-appointed committee representing current claimants and legal representatives for future claimants, according to the announcement earlier this week. The deal still must be approved by the U.S. Bankruptcy Court, the U.S. District Court, and by 75 percent of the current claimants spread across the U.S. The bankruptcy court previously rejected the first reorganiza...



British Researchers Hopeful About Gene-Targeting Mesothelioma...

Thu, 17 Mar 2016 13:34:01 +0100

A new study highlights the potential of a drug designed to slow the growth of mesothelioma tumors from the inside out.(PRWeb March 17, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13271496.htm (Source: PRWeb: Medical Pharmaceuticals)



Mesothelioma in iron ore (taconite) miners

Wed, 16 Mar 2016 00:00:00 +0100

Lambert et al1 report on the relationship between exposure to elongate mineral particles (EMPs) and the incidence of mesothelioma among Minnesota iron ore miners. In a previous study, mesothelioma mortality was found to be increased among workers employed in the Minnesota mining industry.2 Based on 30 observed deaths, a standardised mortality ratio (SMR) of 2.77 with a 95% CI of 1.87 to 3.96 was found among the 31 067 workers most likely engaged in taconite mining and refining, as opposed to haematite mining. Taconite, but not haematite, mining and processing is known to entail exposure to non-asbestiform amphibole and non-amphibole EMPs (predominantly). These results appear to be in contrast to the view that non-asbestiform EMPs are associated with little or no carcinogenic risk.3 Ho...



Welding, a risk factor of lung cancer: the ICARE study

Wed, 16 Mar 2016 00:00:00 +0100

Conclusions Although these results should be confirmed, we showed that type of welding and mode of workpiece preparation are important determinants of the lung cancer risk in regular welders. (Source: Occupational and Environmental Medicine)

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[BRCA1 associated protein 1 (BAP1) expression in pleural diffuse malignant mesothelioma: A comparative cytological and histological analyses on 50 patients].

Wed, 16 Mar 2016 00:00:00 +0100

CONCLUSION: Loss of BAP1 expression is an indicator of MMD in a context of mesothelial proliferation. This immunohistochemistry could be integrated in the panel of immunostaining used for MMD diagnosis, either on histological or cytological samples. Furthermore, loss of BAP1 expression guides the patient to an oncology genetic counseling in order to eliminate a MMD developed as part of a constitutional genetic defect. PMID: 26995100 [PubMed - as supplied by publisher] (Source: Annales de Pathologie)



Medical News Today: Mesothelioma gene-targeting drug looks hopeful

Tue, 15 Mar 2016 10:00:00 +0100

A new study shows that HOX genes are significantly disrupted in malignant mesothelioma, and targeting them with a drug called HXR9 stopped tumors of the cancer growing in mice. (Source: Health News from Medical News Today)



Influence of AQP1 on cell adhesion, migration, and tumor sphere formation in malignant pleural mesothelioma is substratum- and histological-type dependent

Tue, 15 Mar 2016 00:00:00 +0100

In this study we aimed at evaluating the role of AQP1 in cell adhesion, migration, and tumor sphere formation in nonmalignant mesothelial cells (MeT-5A) and in epithelioid (M14K) and sarcomatoid (ZL34) MPM cell lines. We used fibronectin (FN) or homologous cell-derived extracellular martrix (ECM) substratum to investigate the role of AQP1 in these experimental phenotypes, inhibiting AQP1 by 10–5 M mercury chloride (MC). Deposited ECM during cell culture exhibited significant concentration differences among cell types. ZL34 cell adhesion was significantly higher than MeT-5A or M14K cells on FN and ECM. MeT-5A and M14K cell adhesion on FN was sensitive to AQP1 inhibition, whereas AQP1 inhibition on ECM was limited to M14K cells. Wound healing in ZL34 cells was significantly higher than...



[Metastasis revealing malignant peritoneum mesothelioma: About the difficulty to identify the primary tumors].

Tue, 15 Mar 2016 00:00:00 +0100

We report two cases of metastatic malignant peritoneal mesothelioma. In one case, malignant metastatic cells were identified in cervical lymph nodes while in the other case, the cells were found in the liver. In both cases, metastases were identified before discovering the primary tumor. This led to the misdiagnosis of carcinoma of unknown origin. Nevertheless, the histological and immuno-histochemical patterns were typical of malignant mesothelioma. Regarding metastasis of unknown origin, a differentiation of epithelioid peritoneal malignant mesothelioma and adenocarcinoma proved to be difficult. Therefore, we discuss the diagnostic usefulness of immuno-histochemical mesothelioma markers. PMID: 26993587 [PubMed - as supplied by publisher] (Source: Annales de Pathologie)



Mesothelioma Cancer - New Drug HXR9 Provides Hope

Mon, 14 Mar 2016 16:26:49 +0100

New drug HRX9 showing promise for mesothelioma, a cancer of the lining of the lung, treatment (Source: Disabled World)

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New drug hope for mesothelioma

Mon, 14 Mar 2016 04:00:00 +0100

(University of Bradford) A new drug is showing promise as a treatment for mesothelioma -- one of the most lethal cancers of all. The drug, known as HRX9, works by preventing the cancer cells from avoiding apoptosis -- the natural process by which unhealthy and damaged cells close themselves down and die. (Source: EurekAlert! - Medicine and Health)



MesobanK UK: an international mesothelioma bioresource

Mon, 14 Mar 2016 00:00:00 +0100

Malignant pleural mesothelioma causes the greatest societal burden of all the asbestos-related diseases. Progress in better understanding tumour biology will be facilitated by the availability of quality-assured annotated tissue. MesobanK has been created to establish a bioresource of pleural mesothelioma tissue linked to detailed anonymised clinical data. When complete, the bioresource will comprise a 750-patient tissue microarray and prospectively collected tissue, blood and pleural fluid from 300 patients with mesothelioma. Twenty-six new cell lines have also been developed. MesobanK meets all appropriate ethical and regulatory procedures and has recently opened to requests for tissue and data. (Source: Thorax)



DDR1 Inhibition Enhances Immunotoxin Therapy

Mon, 14 Mar 2016 00:00:00 +0100

Recombinant immunotoxins (RIT) have been highly successful in cancer therapy due, in part, to the high cancer-specific expression of cell surface antigens such as mesothelin, which is overexpressed in mesothelioma, ovarian, lung, breast, and pancreatic cancers, but is limited in normal cells. RG7787 is a clinically optimized RIT consisting of a humanized anti-mesothelin Fab fused to domain III of Pseudomonas exotoxin A, in which immunogenic B-cell epitopes are silenced. To enhance the therapeutic efficacy of RITs, we conducted a kinome RNAi sensitization screen, which identified discoidin domain receptor 1 (DDR1), a collagen-activated tyrosine kinase, as a potential target. The collagen/DDR1 axis is implicated in tumor–stromal interactions and potentially affects tumor response to therap...



Occupational exposure in the removal and disposal of asbestos-containing materials in Italy

Sat, 12 Mar 2016 00:00:00 +0100

Conclusions Starting from the analysis of the Italian database of occupational exposure registries, this study outlines the current levels of asbestos exposure in abatement-related sectors, discussing their possible implications for public health policies and surveillance programs. (Source: International Archives of Occupational and Environmental Health)



Exposure‐response estimate for lung cancer and asbestosis in a predominantly chrysotile‐exposed Chinese factory cohort

Fri, 11 Mar 2016 00:00:00 +0100

ConclusionEvidence using quantitative exposure estimates was provided for increased risks of lung cancer mortality and development of asbestosis in a predominantly chrysotile‐exposed cohort. Am. J. Ind. Med. © 2016 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)

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Pilot and feasibility trial of immuno-gene therapy of malignant mesothelioma using intrapleural delivery of adenovirus- interferon-alpha combined with chemotherapy.

Fri, 11 Mar 2016 00:00:00 +0100

CONCLUSIONS: The combination of intrapleural Ad.IFN, celecoxib, and chemotherapy proved safe in patients with MPM. Overall survival rate was significantly higher than historical controls in the second-line group. Results of this study support proceeding with a multi-center randomized clinical trial of chemo-immunogene therapy versus standard chemotherapy alone. PMID: 26968202 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)



Icmt inhibition exerts anti-angiogenic and anti-hyperpermeability activities impeding malignant pleural effusion.

Thu, 10 Mar 2016 18:18:02 +0100

Authors: Magkouta S, Pappas A, Moschos C, Vazakidou ME, Psarra K, Kalomenidis I Abstract Small GTPases are pivotal regulators of several aspects of tumor progression. Their implication in angiogenesis, vascular permeability and tumor-associated inflammatory responses is relevant to the pathobiology of Malignant Pleural Effusion (MPE). Inhibition of isoprenylcysteine carboxylmethyltransferase (Icmt) abrogates small GTPase activation. We therefore hypothesized that cysmethynil, an Icmt inhibitor would limit pleural fluid accumulation in two models, a lung-adenocarcinoma and a mesothelioma-induced MPE. Cysmethynil significantly reduced MPE volume in both models and tumor burden in the adenocarcinoma model. It inhibited pleural vascular permeability and tumor angiogenesis in vivo and r...



Improving Mesothelioma Survival by Targeting New Genetic Mutations

Thu, 10 Mar 2016 14:21:38 +0100

Research from Brigham and Women’s Cancer Center in Boston recently identified a distinct spectrum of genetic mutations in pleural mesothelioma tumors, a blockbuster finding that should significantly improve future treatment of the disease. It was the breakthrough the mesothelioma community was anticipating. “This is probably the most significant advancement in the treatment of mesothelioma since the advent of cytoreductive surgery,” thoracic surgeon Dr. David Sugarbaker, director of the Lung Institute at Baylor College of Medicine and America’s foremost authority on pleural mesothelioma, told Asbestos.com. “This is very exciting. It could mean long-term survival is a reality for a large number of patients.” Sugarbaker co-authored the research study published this month...



Research Supports Innovative Prevention Strategy for Malignant...

Wed, 09 Mar 2016 21:34:02 +0100

Scientists say attacking the underlying cause of inflammation at the cellular level may offer a way to stop mesothelioma before it starts.(PRWeb March 09, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13254891.htm (Source: PRWeb: Medical Pharmaceuticals)



Risk of Lung Cancer in Workers Exposed to Benzidine and/or Beta-Naphthylamine: A Systematic Review and Meta-Analysis.

Wed, 09 Mar 2016 01:42:02 +0100

Authors: Tomioka K, Saeki K, Obayashi K, Kurumatani N Abstract Benzidine (BZ) and beta-naphthylamine (BNA) have been classified as definite human carcinogens for bladder cancer by the International Agency for Research on Cancer. However, the epidemiological evidence for an association between exposure to BZ and/or BNA and lung cancer has been inconclusive. We conducted a systematic review and meta-analysis to determine the risk for lung cancer among workers exposed to BZ/BNA. A systematic literature search was conducted to identify studies that had reported occupational BZ/BNA exposure and the outcome of interest (lung cancer death and/or incidence). Meta-analyses were performed using random effects models to combine standardized mortality ratios (SMRs) or standardized incidence ra...

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A pilot study of volumetric-modulated arc therapy for malignant pleural mesothelioma

Tue, 08 Mar 2016 08:00:00 +0100

Malignant pleural mesothelioma (MPM) is an extremely difficult disease to treat. This pilot study investigates the feasibility of using volumetric-modulated arc ther­apy (VMAT) for malignant pleural mesothelioma (MPM), and compares VMAT to static field intensity-modulated radiotherapy (IMRT) for five patients. To identify the best treatment technique for MPM, in five patients, we made a representative comparative analysis of two kinds of techniques for radiation therapy planning: IMRT and VMAT. The plans were created for an Elekta Synergy linear accelerator with 6 MV photons using Oncentra version 4.3 treatment planning system. Dose prescription was 50 Gy to the average of the planning target volume (PTV). PTV coverage and homogeneity, dose of organs at risk, numbers of segments, MUs, and...



MWCNTs Induce ROS Generation, ERK Phosphorylation, and SOD-2 Expression in Human Mesothelial Cells

Tue, 08 Mar 2016 00:00:00 +0100

This study was conducted to investigate the alteration of SOD-2 expression in the human mesothelial cell lines Met-5A after exposure to nontoxic doses of MWCNTs and the potential signaling pathway. The parameters measured included the viability, morphological change, superoxide formation, extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation, and messenger RNA (mRNA)/protein levels of SOD-2. Our results showed that MWCNTs upregulated SOD-2 expression at both mRNA and protein level. Coincidently, both superoxide formation and ERK1/2 phosphorylation were observed in Met-5A cells exposed to MWCNTs and were diminished by pretreatment with the reactive oxidative species (ROS) scavenger, N-acetyl-l-(+)-cysteine (NAC). To further investigate the role of ROS/ERK1/2 in MWCNTs-induced S...



Risk of occupational exposure to asbestos, silicon and arsenic on pulmonary disorders: Understanding the genetic-epigenetic interplay and future prospects.

Tue, 08 Mar 2016 00:00:00 +0100

CONCLUSION: The link between genotype and phenotype and its association with disease susceptibility is very complex in nature due to several factors like person's environment, lifestyle and nutritional status. The epigenome is dynamic as well as reversible and can be reshaped further by certain dietary components throughout its life. In the present review, we have addressed the role of molecular pathogenesis of occupational lung diseases based on the genetic variability and epigenetic alterations and also attempted to highlight the promising aspect of dietary interventions to counter toxic outcomes upon occupational exposure to asbestos, silicon or arsenic. PMID: 26966890 [PubMed - as supplied by publisher] (Source: Environmental Research)



Canada Admits Using Asbestos in New Public Buildings

Mon, 07 Mar 2016 14:13:01 +0100

The argument to ban asbestos in Canada is growing stronger after government officials admitted using the carcinogen in the renovation and construction of federal buildings. Members of the nation’s trade union association also say the importation of asbestos-containing materials, specifically asbestos cement pipes installed in government buildings, is on the rise. "That they're continuing to use a known carcinogen in the workplace is just unbelievable," said Laura Lozanski, occupational health and safety officer at the Canadian Association of University Teachers. Government officials with Public Services and Procurement and the Canada Review Agency acknowledged the use of asbestos in federal buildings — even as the government is undergoing asbestos abatement projects — after ...

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Researchers Find Mesothelioma Survival Advantage in Adding Amatuximab...

Sun, 06 Mar 2016 19:34:02 +0100

Scientists say patients with unresectable pleural mesothelioma who are going through chemotherapy may live longer if treated with the monoclonal antibody amatuximab.(PRWeb March 05, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13249708.htm (Source: PRWeb: Medical Pharmaceuticals)



Biomonitoring of genotoxic effects for human exposure to nanomaterials: The challenge ahead

Sun, 06 Mar 2016 00:00:00 +0100

Publication date: Available online 4 March 2016 Source:Mutation Research/Reviews in Mutation Research Author(s): Laetitia Gonzalez, Micheline Kirsch-Volders Exposures to nanomaterials (NMs), with their specific physico-chemical characteristics, are likely to increase over the next years, as their production for industrial, consumer and medical applications is steadily rising. Therefore, there is an urgent need for the implementation of human biomonitoring studies of genotoxic effects after NM exposures in order to monitor and assure safety for workers and the general population. In this review, most commonly used biomarkers of early genetic effects were analyzed for their adequacy after NM exposures. A more in depth analysis of the ex vivo/in vitro lymphocyte MN assay was performed, al...



A catalogue of treatment and technologies for malignant pleural mesothelioma.

Sat, 05 Mar 2016 20:48:02 +0100

Authors: Schunselaar LM, Quispel-Janssen JM, Neefjes JJ, Baas P Abstract Malignant pleural mesothelioma is an aggressive fatal malignancy with a prognosis that has not significantly improved in the last decades. This review summarizes the current state of treatment and the various attempts that made to improve overall survival for patients with malignant pleural mesothelioma. It also discusses technologies and protocols to test new and hopefully more effective compounds in a more individualized manner. These developments are expected to improve the prognosis for this group of patients. PMID: 26943000 [PubMed - as supplied by publisher] (Source: Expert Review of Anticancer Therapy)



Mesothelioma of the tunica vaginalis in a patient with giant hydrocele

Sat, 05 Mar 2016 07:35:05 +0100

Abstract The present report describes a case where typical findings of traumatic glenohumeral interposition of rotator cuff stumps were surgically confirmed. This condition is a rare complication of shoulder trauma. Generally, it occurs in high-energy trauma, frequently in association with glenohumeral joint dislocation. Radiography demonstrated increased joint space, internal rotation of the humerus and coracoid process fracture. In addition to the mentioned findings, magnetic resonance imaging showed massive rotator cuff tear with interposition of the supraspinatus, infraspinatus and subscapularis stumps within the glenohumeral joint. Surgical treatment was performed confirming the injury and the rotator cuff stumps interposition. It is important that radiologists and orthopedic surgeons...



Researchers Identify Genetic Mutations Behind Malignant Mesothelioma,...

Thu, 03 Mar 2016 17:19:01 +0100

The discovery of several previously unidentified gene alterations may open the door to new mesothelioma treatment options.(PRWeb March 03, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13244593.htm (Source: PRWeb: Medical Pharmaceuticals)

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Moffitt Launches New Mesothelioma Clinical Trials in Tampa

Thu, 03 Mar 2016 12:30:36 +0100

The mesothelioma program at the Moffitt Cancer Center in Tampa opened two new clinical trials recently, expanding efforts to provide patients throughout the state with more treatment options. Both mesothelioma-specific, phase II trials are designed as second-line therapies involving options that have shown success with other types of cancer. “If a patient is willing and able, we would encourage them to look at these opportunities,” said Dr. Tawee Tanvetyanon, Moffitt medical oncologist and mesothelioma specialist. “People look to trials today because they can find the newest, and sometimes the best, treatment before it is available everywhere.” The two new clinical trials at Moffitt, involving unresectable pleural mesothelioma, are exploring the effectiveness of: T...



Evaluation of Machine Learning Algorithm Utilization for Lung Cancer Classification Based on Gene Expression Levels.

Thu, 03 Mar 2016 10:52:05 +0100

CONCLUSIONS: Machine learning algorithms can be used for lung cancer morphology classification and similar tasks based on gene expression level evaluation. PMID: 26925688 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)



Drug Company Says Failed Trial May Not Be the End for Potential...

Wed, 02 Mar 2016 02:07:03 +0100

An immunotherapy drug that failed to improve mesothelioma survival in a recent clinical trial may still be used as part of a mesothelioma treatment combination.(PRWeb March 01, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13239495.htm (Source: PRWeb: Medical Pharmaceuticals)



Fiber analysis vignettes: Electron microscopy to the rescue!

Wed, 02 Mar 2016 00:00:00 +0100

Authors: Roggli VL Abstract There has been considerable interest in the exposure doses that contribute to the various asbestos-associated diseases. Epidemiological studies have shown important differences in the contributions of the various fiber types to asbestos-related diseases, with the amphiboles showing a greater degree of potency as compared to chrysotile. However, epidemiological studies have occasionally provided misleading results. Over the past several decades, there have been several examples where fiber analysis using electron microscopy produced unexpected results which were important to our understanding of disease-exposure relationships. It is the purpose of this article to summarize these fiber analysis vignettes. PMID: 26934117 [PubMed - as supplied by publish...



Tremelimumab Failed to Extend Mesothelioma Survival Rates

Tue, 01 Mar 2016 16:35:16 +0100

The highly touted immunotherapy drug tremelimumab failed to extend the lives of malignant mesothelioma patients, according to the London-based manufacturer after it ended its multicenter clinical trial Monday. Researchers were testing tremelimumab — with considerable fanfare — as a second- and third-line treatment for unresectable mesothelioma in a phase IIb trial. The immunotherapy drug already had shown success with other cancers. “We are disappointed that tremelimumab monotherapy did not demonstrate a survival benefit in this patient population,” Robert Iannone, head of immuno-oncology at AstraZeneca said in a statement released Monday. “We remain confident in tremelimumab’s clinical activity in combination.” The announcement came less than a month after a report ...

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Medical News Today: Gene study uncovers 'spectrum of mutations' in mesothelioma

Tue, 01 Mar 2016 15:00:00 +0100

A genomic analysis of over 200 mesothelioma tumors uncovers previously unknown mutations - some of which arise in other cancers and may be treatable with existing drugs. (Source: Health News from Medical News Today)



Identifying Thoracic Malignancies Through Pleural Fluid Biomarkers: A Predictive Multivariate Model

Tue, 01 Mar 2016 06:00:00 +0100

In conclusion, panels of 4 (i.e., MMP-9, cathepsin-B, C-reactive protein, chondroitin sulfate), or 3 (i.e., CA19-9, CA15-3, kallikrein-12) different protein biomarkers on pleural fluid samples are highly discriminative for signaling a malignant versus tuberculous effusion, or lung adenocarcinoma versus mesothelioma, respectively. Cathepsin-B could also be helpful in establishing the presence of a lymphomatous effusion versus that of TB, if the patient's age is simultaneously taken into consideration. (Source: Medicine)



Talcum Powder: Just How Much Risk Does It Pose?

Tue, 01 Mar 2016 02:38:12 +0100

Johnson & Johnson is a trusted name whose baby powder has long been a staple of many homes. The powder absorbs excess moisture and protects skin from chafing and irritating rashes. Women in particular use it as a part of feminine hygiene. Now we are being told that this household item could be linked to cancer. Johnson & Johnson just lost a huge lawsuit brought by the family of a woman who died of ovarian cancer after years of using the product. The decision wasn't actually based on hard evidence of a known link between talc and ovarian cancer, leading to a lot of confusion for consumers. Baby powder's main ingredient is talc -- a natural product made of magnesium, silicon, hydrogen and oxygen. In addition to baby powder, talc is found in a lot of cosmetic products. Talc baby powder wa...



Integrated Analysis of Dysregulated ncRNA and mRNA Expression Profiles in Humans Exposed to Carbon Nanotubes

Tue, 01 Mar 2016 00:00:00 +0100

Conclusion This study is the first to investigate aberrant changes in mRNA and ncRNA expression profiles in the blood of humans exposed to MWCNT. The significant changes in several miRNAs and mRNAs expression as well as their regulatory networks are important for getting molecular insights into the MWCNT-induced toxicity and pathogenesis in humans. Further large-scale prospective studies are necessary to validate the potential applicability of such changes in mRNAs and miRNAs as prognostic markers of MWCNT exposures in humans. (Source: PLoS One)



A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Steven C Kao, Michaela B Kirschner, Wendy A Cooper, Thang Tran, Sjaak Burgers, Casey Wright, Tiny Korse, Daan van den Broek, James Edelman, Michael Vallely, Brian McCaughan, Nick Pavlakis, Stephen Clarke, Mark P Molloy, Nico van Zandwijk & Glen Reid (Source: British Journal of Cancer)

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The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy

Tue, 01 Mar 2016 00:00:00 +0100

Helmut Sies established the concept of oxidative stress in 1985. However, it took some time to introduce this concept into pathology, where investigators count on formalin‐fixed paraffin‐embedded tissue sections. I sought out antigens for this purpose based on an oxidative stress‐induced rat renal carcinogenesis model, which revealed that 8‐hydroxy‐2′‐deoxyguanosine and 4‐hydroxy‐2‐nonenal‐modified proteins are ideal. These two monoclonal antibodies successfully revealed the involvement of oxidative stress in numerous human diseases, including carcinogenesis and atherosclerosis. Shigeru Okada established the aforementioned ferric nitrilotriacetate (Fe‐NTA)‐induced rat renal carcinogenesis model, which thus far has answered many questions regarding the presence of ...



Small cell mesothelioma: A rare entity and diagnostic pitfall mimicking small cell lung carcinoma on fine‐needle aspiration

Tue, 01 Mar 2016 00:00:00 +0100

This report demonstrates the difficulties in cytologic evaluation of lung FNAs in differentiating SCM from SCLC or other small round blue cell tumors. As therapy differs for SCM, early recognition of the cytologic features is essential in making the correct diagnosis needed for appropriate clinical management. Diagn. Cytopathol. 2016. © 2016 Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)



Pemetrexed‐induced scleroderma‐like conditions in the lower legs of a patient with non‐small cell lung carcinoma

Tue, 01 Mar 2016 00:00:00 +0100

We describe a case of pemetrexed‐induced scleroderma‐like conditions in the lower legs of a patient whose pulmonary carcinoma has been relatively well controlled, with prolongation of the dose interval, in spite of the discomfort in both his legs. Skin biopsy revealed dermal fibrosis and dilated lymph vessels in the dermis, but lymphocytic infiltration around the lymph vessels, in contrast to the blood vessels, was minimal. Immunohistochemical staining revealed that the major subsets of T cells that had infiltrated around blood vessels were CD3 and CD45Ro, but no B cells were detected. High serum levels of interleukin (IL)‐4 and IL‐6 suggested that T cells, which secrete these cytokines, may be involved in the pathogenesis of this condition. Magnetic resonance imaging of the lower ...



Mesothelioma Gene Study ID's Possible Treatment Targets (CME/CE)

Mon, 29 Feb 2016 16:00:00 +0100

(MedPage Today) -- "Mesothelioma patients should be sequenced" (Source: MedPage Today Public Health)



New genetic insights into mesothelioma

Mon, 29 Feb 2016 05:00:00 +0100

(Brigham and Women's Hospital) In a comprehensive genomic analysis using more than 200 mesothelioma tumors, investigators from Brigham and Women's Hospital have found previously unknown genetic alterations, including some that may be clinically actionable, as well as others that may improve diagnostics, screening and predictions about outcomes for patients. The team's results are published this week in Nature Genetics. (Source: EurekAlert! - Cancer)

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New Genetic Insights into Mesothelioma

Mon, 29 Feb 2016 00:00:00 +0100

By sequencing samples from more than 200 tumors, researchers have uncovered rare but actionable mutations and a broader understanding of the disease’s mutation patterns. (Source: BWH News)



New Genetic Insights into Mesothelioma (Brigham and Women’s Hospital)

Mon, 29 Feb 2016 00:00:00 +0100

Mesothelioma is a rare but deadly form of cancer: the five-year survival rate for patients diagnosed with the disease is between five and ten percent. Although aggressive surgery can help some patients with early-stage mesothelioma, current treatments for patients with more advanced mesothelioma are not effective. Physician-researchers from the International Mesothelioma Program at Brigham and Women's Hospital (BWH) have been caring for patients with mesothelioma for the past 25 years and, in pa... (Source: National Comprehensive Cancer Network)



Single-dose dexamethasone for the prevention of pemetrexed associated cutaneous adverse reactions

Sat, 27 Feb 2016 00:00:00 +0100

We report 14 cases of metastatic non-small-cell-lung-cancer patients who were premedicated with a single dose of dexamethasone 20 mg prior to pemetrexed or pemetrexed-based chemotherapy. None of these patients reported a grade 3 or above skin reactions over the course of their treatments. These findings suggest that a single dose of dexamethasone 20 mg may be an alternative premedication regimen in patients with metastatic non small cell lung cancer receiving pemetrexed or pemetrexed-based chemotherapy. (Source: Journal of Oncology Pharmacy Practice)



Benign multicystic mesothelioma of peritoneum complicating acute appendicitis in a man: a case report

Sat, 27 Feb 2016 00:00:00 +0100

Conclusions We showed that an acute presentation of a benign neoplasm represents a diagnostic and therapeutic challenge for the surgeon, because of the difficult differential diagnosis that acute presentation can sometimes pose and the trouble that an emergence treatment can imply. (Source: Journal of Medical Case Reports)

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Mesotheliomas show higher hyaluronan positivity around tumor cells than metastatic pulmonary adenocarcinomas.

Fri, 26 Feb 2016 23:19:02 +0100

Authors: Kari T, Ylermi S, Paavo P, Jyrki P, Reijo S, Kirsi R Abstract Hyaluronan is a unique glycosaminoglycan of the extracellular matrix, abundant in normal connective tissues but highly increased in many pathological conditions like cancer. Mesothelioma, one of the most malignant cancer types, is associated with high content of hyaluronan, with elevated levels of hyaluronan in pleural effusions and serum of the patients. Metastatic lung adenocarcinomas are typically less aggressive and have a better prognosis as compared to mesotheliomas, a reason why it is highly important to find reliable tools to differentiate these cancer types. The main purpose of this study was to evaluate the amount of hyaluronan, hyaluronan producing synthases (HAS's) and hyaluronan receptor CD44, in me...



Johnny Lattner: Heisman Winner and Steeler Dies of Mesothelioma

Fri, 26 Feb 2016 19:35:39 +0100

Heisman Trophy winner and two-time college football All-American Johnny Lattner died of mesothelioma earlier this month, joining a growing list of famous people stricken by this rare and aggressive cancer. Another hero lost to the horror of asbestos. Lattner, who died at 83, won the Heisman in 1953 as a senior at the University of Notre Dame. He was featured that year on the cover of Time Magazine, which hailed him as a shining star. He played only one year in the National Football League with the Pittsburgh Steelers, was selected to the Pro Bowl, but then enlisted in the U.S. Air Force, where he suffered a career-ending knee injury. The Notre Dame campus observed a moment of silence in his honor recently before a basketball game against the Louisville Cardinals. Lattner was...



Incidence of malignant mesothelioma in New Zealand and Australia: a global snapshot.

Fri, 26 Feb 2016 12:44:02 +0100

Authors: Soberg MJ, van Zandwijk N PMID: 26914008 [PubMed - as supplied by publisher] (Source: New Zealand Medical Journal)



Erratum to clinical role of a new prognostic score using platelet-to-lymphocyte ratio in patients with malignant pleural mesothelioma undergoing extrapleural pneumonectomy.

Thu, 25 Feb 2016 05:57:02 +0100

Authors: Abstract [This corrects the article on p. 1898 in vol. 7, PMID: 26716028.]. PMID: 26904249 [PubMed] (Source: Journal of Thoracic Disease)



Asymptomatic localized pleural amyloidosis mimicking malignant pleural mesothelioma: report of a case.

Thu, 25 Feb 2016 05:57:02 +0100

Authors: Nakano T, Endo S, Tetsuka K, Fukushima N Abstract We herein report an asymptomatic 65-year-old male with localized pleural amyloidosis mimicking malignant pleural mesothelioma. He had a history of exposure to asbestos and was admitted for investigation of an abnormal pleural thickness detected by chest radiography. Positron emission tomography showed elevation of standardized uptake value corresponding to the pleural thickness. Partial pleurectomy including the tumor was performed for the purpose of diagnosis and local disease control. The pathological examination showed that the tumor was pleural amyloidosis. The tumor was diagnosed as localized primary amyloidosis, because serum monoclonal protein concentration did not increase. Pleural amyloidosis should be considered a...

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Ganglioneuroblastoma: Unusual presentation as a pleural mass mimicking mesothelioma

Thu, 25 Feb 2016 00:00:00 +0100

We present a case of GNB occurring as pleural mass in a 2-year-old boy, which led to diagnostic confusion. On fine-needle aspiration cytology (FNAC), it was misinterpreted as mesothelioma. He underwent thoracotomy with excision of the mass. Histopathological findings showed features of a biphasic tumor suggestive of mesothelioma. Immunohistochemistry (IHC) performed for mesothelioma markers were inconclusive. On review of the histology slides, GNB was considered, which was subsequently proven by IHC. The rarity of this tumor, along with its nearly restricted occurrence at a young age, necessitates a strong suspicion in patients presenting with a symptomatic intrathoracic mass. (Source: Lung India)



The comparison of high‐resolution computed tomography findings in asbestosis and idiopathic pulmonary fibrosis

Mon, 22 Feb 2016 22:34:13 +0100

ConclusionsThere are significant differences between IPF and asbestosis in the parenchymal and pleural abnormalities on CT. Am. J. Ind. Med. © 2016 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)



Fine needle aspiration biopsy of metastatic malignant mesothelioma with myxoid change and signet ring cells: A case report and review of the literature

Mon, 22 Feb 2016 00:00:00 +0100

Manisha M Mishra, Carol F Farver, Deborah J ChuteCytoJournal 2016 13(1):4-4Malignant mesothelioma (MM) is a rare neoplasm, which is most commonly encountered in cytology through effusion specimens. Fine needle aspiration biopsy of MM, particularly the epithelioid subtype, can be a source of diagnostic difficulty and may mimic sampling of an adenocarcinoma. This is the first case report to demonstrate abundant extracellular myxoid material and numerous intracellular vacuoles, including signet ring cells, in a fine needle aspirate of metastatic MM. A review of the literature for myxoid change and vacuoles in fine needle aspiration biopsies of MM discloses that vacuoles are found in up to 35% of aspirates of MM, but myxoid change is very rare, reported in <5% of the cases. Cy...



Population pharmacokinetics and exposure–response relationship of amatuximab, an anti-mesothelin monoclonal antibody, in patients with malignant pleural mesothelioma and its application in dose selection

Mon, 22 Feb 2016 00:00:00 +0100

Conclusions In patients with MPM, higher amatuximab exposure in combination with chemotherapy was shown to be associated with longer OS, supporting evaluation of more frequent dosing in future trials to achieve higher exposure and subsequently longer OS. (Source: Cancer Chemotherapy and Pharmacology)



Erratum to: ENOX2-based early detection (ONCOblot) of asbestos-induced malignant mesothelioma 4–10 years in advance of clinical symptoms

Mon, 22 Feb 2016 00:00:00 +0100

(Source: Clinical Proteomics)

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Clinical and pathologic predictors of clinical outcome of malignant pleural mesothelioma.

Sun, 21 Feb 2016 08:07:02 +0100

CONCLUSIONS: Our results showed that anemia and increased Ca125 might be considered negative prognostic parameters in MPM patients and confirmed the prognostic role of histotype, performance status, and response to first-line chemotherapy. PMID: 26893272 [PubMed - as supplied by publisher] (Source: Tumori)



Cutaneous Metastases From Malignant Mesothelioma of the Tunica Vaginalis Testis

Sun, 21 Feb 2016 04:19:55 +0100

We report an additional case with fatal outcome. A 93-year-old man presented with multiple polypoid nodules on the left scrotum. Ulceration was also present, and a firm 5-cm palpable testicular mass was also found. The patient had been exposed to asbestos for 40 years. Histologic examination of a skin biopsy from one of the nodules showed diffuse dermal infiltration of markedly atypical cuboidal cells, with polymorphous and hyperchromatic nuclei. Mitotic figures were common. These cuboidal cells lined clefts, forming a tubular and micropapillary pattern throughout papillary and reticular dermis. Immunohistochemical study showed strong nuclear and cytoplasmic positivity for calretinin, epithelial membrane antigen (cytoplasmic), and cytokeratin-7 (cytoplasmic) and nuclear positivity for Wilm...



On the sensitivity of TG-119 and IROC credentialing to TPS commissioning errors.

Sat, 20 Feb 2016 14:19:02 +0100

Authors: McVicker D, Yin FF, Adamson JD Abstract We investigate the sensitivity of IMRT commissioning using the TG-119 C-shape phantom and credentialing with the IROC head and neck phantom to treatment planning system commissioning errors. We introduced errors into the various aspects of the commissioning process for a 6X photon energy modeled using the analytical anisotropic algorithm within a commercial treatment planning system. Errors were implemented into the various components of the dose calculation algorithm including primary photons, secondary photons, electron contamination, and MLC parameters. For each error we evaluated the probability that it could be committed unknowingly during the dose algorithm commissioning stage, and the probability of it being identified during ...



Fluoro-edenite and carbon nanotubes: The health impact of 'asbestos-like' fibres.

Sat, 20 Feb 2016 10:15:03 +0100

Authors: Miozzi E, Rapisarda V, Marconi A, Costa C, Polito I, Spandidos DA, Libra M, Fenga C Abstract Several decades have passed since Wagner et al demonstrated a causal link between asbestos fibre inhalation and the development of pleural mesothelioma in 1960. It was later suggested that pleural plaques are a benign consequence of exposure to these fibres. Most recently, a significant association between exposure to asbestos and cancer diagnosed at various sites, such as the peritoneum, stomach, pharynx, colon and ovaries has been demonstrated. The great concerns about public health that arose from the scientific evidence presented above have led to the banning of asbestos in several countries. Over the years, the suspicion that particles with a high aspect ratio may have asbesto...



The Next 10 Years As a Mesothelioma Cancer Survivor

Fri, 19 Feb 2016 22:44:31 +0100

February 2016 is here, which means I'm a 10-year survivor of cancer. More than that, I have survived shock -- the shock of a mesothelioma diagnosis, of being told I had a few months to live. I have survived loss -- the loss of my health, the loss of a lung, the loss of an expected kind of life. I have survived the pursuit of justice, a pursuit that can never truly return what was taken. Above all, I have survived fear -- fear of losing my family, fear for my family's future, fear of dying. If you've been reading my 10 Years In 10 Months series, you've witnessed all the moments of survival I just mentioned as each one was given its own chapter; you witnessed them alongside me as I remembered them. You also saw how, without my healing and treatment journey, and without the love and support f...

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EPA Is Close to Finishing Libby Asbestos Cleanup

Fri, 19 Feb 2016 17:25:42 +0100

The U.S. Environmental Protection Agency (EPA) this month announced its final remedial plans for the Libby Asbestos Superfund Site, bringing closure to the largest, longest-running asbestos cleanup project in American history. The EPA project began almost 17 years ago in Montana, stemming from seven decades of vermiculite mining that led to toxic asbestos contamination throughout Libby and nearby Troy. Health officials believe the mines killed more than 400 Libby residents and sickened an estimated 3,000. Exposure to asbestos can lead to several serious illnesses, including asbestosis, lung cancer and mesothelioma. The latency period between exposure and diagnosis of mesothelioma is 20-50 years. The cleanup price has exceeded $540 million and is expected to cost another $64 millio...



Cancer Experts Pinpoint Key Prognostic Factors for Mesothelioma...

Fri, 19 Feb 2016 15:34:06 +0100

Researchers at one of the country’s top cancer centers say the old prognostic scoring systems don’t work for many of today’s mesothelioma patients.(PRWeb February 19, 2016)Read the full story at http://www.prweb.com/releases/2016/02/prweb13223566.htm (Source: PRWeb: Medical Pharmaceuticals)



SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells.

Fri, 19 Feb 2016 13:16:02 +0100

In this report, we show that malignant pleural mesothelioma (MPM) patients whose tumors express high levels of AKT1 exhibit a significantly worse prognosis, whereas no significant correlation with AKT3 expression is observed. We provide data that establish a phosphorylation independent role of AKT1 in affecting MPM cell shape and anchorage independent cell growth in vitro and highlight the AKT1 isoform-specific nature of these effects.We describe that AKT1 activity is inhibited by the loss of SIRT1-mediated deacetylation and identify, by mass spectrometry, 11 unique proteins that interact with acetylated AKT1.Our data demonstrate a role of the AKT1/SIRT1/FOXM1 axis in the expression of the tumor suppressor ERβ. We further demonstrate an inhibitory feedback loop by ERβ, activated by the s...



Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma.

Fri, 19 Feb 2016 13:16:02 +0100

Authors: D'Amato-Brito C, Cipriano D, Colin DJ, Germain S, Seimbille Y, Robert JH, Triponez F, Serre-Beinier V Abstract Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine implicated in acute and chronic inflammatory diseases. MIF is overexpressed in various tumors. It displays a number of functions that provide a direct link between the process of inflammation and tumor growth. Our group recently identified the MIF-receptor CD74 as an independent prognostic factor for overall survival in patients with malignant pleural mesothelioma. In the present study, we compared the levels of expression of MIF and CD74 in different human mesothelioma cell lines and investigated their physiopathological functions in vitro and in vivo. Human mesothelioma cells expressed m...



Long-term toxicity of naturally occurring asbestos in male Fischer 344 rats

Fri, 19 Feb 2016 00:00:00 +0100

(Source: Journal of Toxicology and Environmental Health Part A)

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Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease

Fri, 19 Feb 2016 00:00:00 +0100

Authors: T Chernova, X M Sun, I R Powley, S Galavotti, S Grosso, F A Murphy, G J Miles, L Cresswell, A V Antonov, J Bennett, A Nakas, D Dinsdale, K Cain, M Bushell, A E Willis & M MacFarlane (Source: Cell Death and Differentiation)



The levels of HDAC1 and thioredoxin1 are related to the death of mesothelioma cells by suberoylanilide hydroxamic acid.

Fri, 19 Feb 2016 00:00:00 +0100

In conclusion, SAHA selectively inhibited the growth of Phi and ROB mesothelioma cells, which showed the higher basal level of HDAC1. SAHA-induced Phi cell death was related to oxidative stress and Trx1 levels. PMID: 26936390 [PubMed - as supplied by publisher] (Source: International Journal of Oncology)



Treating peritoneal mesothelioma with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. A case series and review of the literature.

Thu, 18 Feb 2016 06:10:02 +0100

CONCLUSION: Cytoreductive surgery with HIPEC has proved the most effective treatment even when taking account of the cost of significant morbidity. PMID: 26382910 [PubMed - in process] (Source: International Journal of Hyperthermia)



Measured removal rates of chrysotile asbestos fibers from air and comparison with theoretical estimates based on gravitational settling and dilution ventilation.

Thu, 18 Feb 2016 03:00:02 +0100

CONCLUSION: Overall, the scientific weight of evidence indicates that the time necessary for removal of 99% of fibers greater than 5 μm in length (with aspect ratios greater than 3:1) is approximately 20-80 min. PMID: 26671197 [PubMed - in process] (Source: Inhalation Toxicology)



Historical ambient airborne asbestos concentrations in the United States - an analysis of published and unpublished literature (1960s-2000s).

Thu, 18 Feb 2016 03:00:02 +0100

Authors: Abelmann A, Glynn ME, Pierce JS, Scott PK, Serrano S, Paustenbach DJ Abstract Outdoor concentrations of airborne asbestos have been measured throughout the US over time. However, a thorough review and analysis of these data has not been conducted. The purpose of this study is to characterize asbestos concentrations in ambient air by environment type (urban, rural) and by decade, using measurements collected in the absence of known asbestos emission sources. A total of 17 published and unpublished studies and datasets were identified that reported the results of 2058 samples collected from the 1960s through the 2000s across the US. Most studies did not report asbestos fiber type, and data based on different analytical methods (e.g. Phase Contrast Microscopy, Transmission El...

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Are pleural plaques an appropriate endpoint for risk analyses?

Thu, 18 Feb 2016 03:00:02 +0100

Authors: Maxim LD, Niebo R, Utell MJ Abstract This review summarizes the literature on the relation between the development of pleural plaques and non-malignant and malignant disease in cohorts exposed to asbestos and other fibers. The available evidence indicates that, absent any other pleural disease, the presence of pleural plaques does not result in respiratory symptoms or clinically significant impacts on lung function. For certain types of asbestos, the development of pleural plaques is statistically correlated with malignant disease, but the evidence is consistent with the hypothesis that pleural plaques without other pleural disease are a marker of exposure, rather than an independent risk factor. Pleural plaques have also developed in cohorts exposed to other fibers that h...



Systematic review of pleural plaques and lung function.

Thu, 18 Feb 2016 03:00:02 +0100

CONCLUSION: The weight of evidence indicates that pleural plaques do not impact lung function. Observed associations are most likely due to unidentified abnormalities or other factors. PMID: 25518994 [PubMed - indexed for MEDLINE] (Source: Inhalation Toxicology)



Analytical tools for the analysis of β-carotene and its degradation products.

Thu, 18 Feb 2016 02:39:02 +0100

Authors: Stutz H, Bresgen N, Eckl PM Abstract β-Carotene, the precursor of vitamin A, possesses pronounced radical scavenging properties. This has centered the attention on β-carotene dietary supplementation in healthcare as well as in the therapy of degenerative disorders and several cancer types. However, two intervention trials with β-carotene have revealed adverse effects on two proband groups, that is, cigarette smokers and asbestos-exposed workers. Beside other causative reasons, the detrimental effects observed have been related to the oxidation products of β-carotene. Their generation originates in the polyene structure of β-carotene that is beneficial for radical scavenging, but is also prone to oxidation. Depending on the dominant degradation mechanism, bond cleavage...



Re: Bias in the proportionate mortality ratio analysis of small study populations: A case on analyses of radiation and mesothelioma.

Thu, 18 Feb 2016 01:49:02 +0100

Authors: Hein MJ, Schubauer-Berigan MK PMID: 26189732 [PubMed - in process] (Source: International Journal of Radiation Biology)



Feasibility Study on Production of Fiber Cement Board Using Waste Kraft Pulp in Corporation with Polypropylene and Acrylic Fibers

Thu, 18 Feb 2016 00:00:00 +0100

Publication date: 2016 Source:Materials Today: Proceedings, Volume 3, Issue 2 Author(s): Morteza Khorami, Eshmaeil Ganjian, Anupam Srivastav This research attempts to find the cheap and accessible fibers as an asbestos replacement in the production of fiber cement board. In this research, waste Kraft pulp which gained from waste cardboard in corporation with two polymeric fibers; acrylic and polypropylene fibers which are normally used in fabric industry, were used. In both groups, nano silica was used as an additive. Mechanical characteristics of the specimens were tested and analyzed according to relevant standards. The results showed that the specimens made out of waste cardboard and acrylic fibers could meet the standard's requirements and have adequate potential to be used as an ...

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Intensive Care Management of Patient After Cytoreductive Surgery and HIPEC - A Concise Review

Thu, 18 Feb 2016 00:00:00 +0100

Abstract Hyperthermic intraperitoneal chemotherapy (HIPEC) in combination with cytoreductive surgery is a targeted treatment approach in which tumors that have spread through the lining of the abdomen are removed and then heated chemotherapy is perfused throughout the abdomen, with the intent of killing any remaining cancer cells that may be present after all the visible disease has been removed surgically. The chemotherapy is administered in high dosages to the targeted area and washed out, thereby limiting the systemic toxicity. The procedure usually takes 8 to 18 h and is most commonly used to treat appendiceal, colorectal or mesothelioma tumors including those that have failed standard chemotherapy and/or prior surgeries. Patients face major and life threatening derangements ...



Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases

Thu, 18 Feb 2016 00:00:00 +0100

Malignant mesothelioma (DMM) is a tumor of mesothelial origin that is associated with asbestos exposure [1]. Asbestos exposure is likewise associated with lung cancer (LC) and has a synergistic relationship with smoking in terms of increasing the risk of developing LC [2]. Selikoff et al. described a multiplicative model in insulators, showing that cigarette smokers exposed to asbestos have a 55-fold increased risk of developing lung cancer over those not exposed to either agent [3]. Individuals with concurrent DMM and LC have been rarely reported. (Source: Lung Cancer)



Analysis of BAP1 Germline Gene Mutation in Young Uveal Melanoma Patients.

Wed, 17 Feb 2016 23:36:02 +0100

CONCLUSIONS: This study suggests that a small subset of patients with early onset UM has germline mutation in BAP1. While young patients with UM should be screened for germline BAP1 mutations, our results suggest that there is a need to identify other candidate genes which are responsible for UM in young patients. PMID: 25687217 [PubMed - in process] (Source: Ophthalmic Genetics)



UK asbestos imports and mortality due to idiopathic pulmonary fibrosis

Wed, 17 Feb 2016 00:00:00 +0100

Conclusions The strength of the association between IPF mortality and historic asbestos imports was similar to that seen in an established asbestos-related disease, i.e. mesothelioma. This finding could in part be explained by diagnostic difficulties in separating asbestosis from IPF and highlights the need for a more accurate method of assessing lifetime occupational asbestos exposure. (Source: Occupational Medicine)

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Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma.

Wed, 17 Feb 2016 00:00:00 +0100

Authors: Togo Y, Yoshikawa Y, Suzuki T, Nakano Y, Kanematsu A, Zozumi M, Nojima M, Hirota S, Yamamoto S, Hashimoto-Tamaoki T Abstract Somatic mutations of the BRCA1 associated protein-1 (BAP1) gene, which maps to 3p21, have been found in several tumors including malignant mesothelioma, uveal melanoma, and renal cell carcinoma (RCC). The role of BAP1 inactivation in tumor development remains unclear. It has been reported that Vhl knock-out mice did not develop RCC, but Vhl knock-out mice with single allele loss of Bap1 in nephron progenitor cells developed RCC, indicating that Bap1 inactivation may be essential in murine renal tumorigenesis. To clarify the role of BAP1 in human RCC development, we performed mutation analyses, including copy number detection of BAP1 and assessment of...



Mesothelioma Tissue Bank Will Get $5.5M Funding Grant

Tue, 16 Feb 2016 15:00:43 +0100

The National Institute for Occupational Safety and Health (NIOSH) plans to award a five-year, $5.5 million grant to continue funding the much-needed National Mesothelioma Virtual Bank (NMVB) through 2021. The NMVB is a biospecimen registry designed to facilitate scientific research of mesothelioma, the rare and aggressive cancer caused by exposure to asbestos. It is the only federally funded program designed exclusively for mesothelioma research. "It's often difficult to pull enough material together for [researching] a disease like this," Dr. Ainsley Weston, associate director for science at NIOSH, told Asbestos.com. "This project provides access to the tools that researchers need to make progress." The NMVB has been based at the University of Pittsburgh Medical Center since its ...



Para-occupational exposures to asbestos: lessons learned from Casale Monferrato, Italy

Tue, 16 Feb 2016 00:00:00 +0100

This study provides strong evidence of an association between pleural mesothelioma and non-occupational exposures to asbestos. An approximately twofold increase in risk was observed for having lived with a family member who worked in the Eternit asbestos cement plant (OR=2.4, 95% CI 1.3 to 4.4), or having been exposed from domestic or environmental sources (OR=2.0, 95% CI 1.2 to 3.2). This is unfortunately not a new story. In the seminal report by Wagner in 19605 of a series of mesothelioma cases with exposure to crocidolite asbestos exposure in South Africa, 18 of the 32 cases were born in the... (Source: Occupational and Environmental Medicine)



Pleural mesothelioma and occupational and non-occupational asbestos exposure: a case-control study with quantitative risk assessment

Tue, 16 Feb 2016 00:00:00 +0100

Conclusions Risk of PMM increased with cumulative asbestos exposure and also in analyses limited to subjects non-occupationally exposed. Our results also provide indication of risk associated with common sources of environmental exposure and are highly relevant for the evaluation of residual risk after the cessation of asbestos industrial use. (Source: Occupational and Environmental Medicine)



Incidence and survival trends for malignant pleural and peritoneal mesothelioma, Australia, 1982-2009

Tue, 16 Feb 2016 00:00:00 +0100

Conclusions Australia's malignant mesothelioma incidence rates appear to have reached maximum levels but with differences over time by age, gender and tumour location. Improvements over time in survival provide a glimpse of hope for this almost invariably fatal disease. (Source: Occupational and Environmental Medicine)

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A Call to Start School Later

Mon, 15 Feb 2016 15:48:26 +0100

My school system wants to change their 7:17 a.m. high school start time to 8:30 a.m. You'd think the sky was falling. I've been watching my district try to make this change since we moved here 16 years ago. Back then my oldest child was 12. As a medical writer, I was concerned her future high school would start at just after 7 a.m., a time doctors were already saying was incompatible with healthy teen sleep. I was relieved when I read that school leaders knew this research and were planning to pilot a 9 a.m. start time. But that pilot never got off the ground. My daughter and my younger kids all started high school at 7:17, and to this day high schools here still start that early, with some kids at bus stops before 5:30 a.m. Meanwhile, that 12-year-old is 28 and just had a baby of her own....



Mesothelioma with superior vena cava obstruction in young female following short latency of asbestos exposure

Mon, 15 Feb 2016 00:00:00 +0100

Anupam Patra, Susmita Kundu, Amitava Pal, Sayantan SahaJournal of Cancer Research and Therapeutics 2015 11(4):940-942An 18 years female was admitted with right-sided chest pain, dry cough, and low-grade fever and weight loss for last 1 month. On examination, patient had features of superior vena cava (SVC) syndrome with right-sided pleural effusion. Chest X-ray showed mediastinal widening with nonhomogenous opacity mainly in the periphery of right upper and mid zone with right-sided pleural effusion. Ultrasonography thorax confirmed mild pleural effusion. Pleural fluid analysis showed lymphocytic, exudative, low adenosine deaminase with negative for Pap smear. Contrast-enhanced computed tomography (CT) thorax revealed large extensive nodular soft tissue lesion along right mediastinum as we...



Cystic adenomatoid tumor of the uterus

Mon, 15 Feb 2016 00:00:00 +0100

We present a case of a cystic adenomatoid tumor in a 40-year-old woman. The tumor was an intramural multicystic mass, histologically similar to a multicystic mesothelioma. Cystic adenomatoid tumors of the uterus are extremely rare. They present with a wide differential diagnosis in radiology. The tumors are known to be benign and awareness of this rare entity is the key to its diagnosis for a pathologist. (Source: Journal of Cancer Research and Therapeutics)



Complications of indwelling pleural catheter use and their management.

Sun, 14 Feb 2016 06:52:02 +0100

Authors: Lui MM, Thomas R, Lee YC Abstract The growing utilisation of indwelling pleural catheters (IPCs) has put forward a new era in the management of recurrent symptomatic pleural effusions. IPC use is safe compared to talc pleurodesis, though complications can occur. Pleural infection affects <5% of patients, and is usually responsive to antibiotic treatment without requiring catheter removal or surgery. Pleural loculations develop over time, limiting drainage in 10% of patients, which can be improved with intrapleural fibrinolytic therapy. Catheter tract metastasis can occur with most tumours but is more common in mesothelioma. The metastases usually respond to analgaesics and/or external radiotherapy. Long-term intermittent drainage of exudative effusions or chylothorax ca...



Japanese Study Focuses on Role of RNA in Mesothelioma Chemotherapy...

Sat, 13 Feb 2016 10:19:02 +0100

Scientists say manipulating the genetic material inside mesothelioma cells could make them more susceptible to treatment.(PRWeb February 12, 2016)Read the full story at http://www.prweb.com/releases/2016/02/prweb13210641.htm (Source: PRWeb: Medical Pharmaceuticals)

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Orlando Firefighters Exposed to Asbestos Were Not Warned

Fri, 12 Feb 2016 13:04:17 +0100

More than a dozen Orlando firefighters were exposed to asbestos earlier this month because their supervisors failed to warn them of the known dangers. The families of many of those firefighters worry secondhand exposure to the deadly mineral could place them at risk of developing mesothelioma or other asbestos-related diseases. “It’s everywhere, you know?” said Andrea Donohoe, wife of one of the Orlando Fire Department firefighters exposed to asbestos. “Our baby is riding in his car. I was riding in his car. We’re all now exposed to asbestos.” Her husband, Anthony Donohoe, and more than a dozen other firefighters were exposed to the carcinogen while removing flooring from an abandoned apartment building the fire department had planned to use for training. “We were...



Usual interstitial pneumonia in asbestos exposed cohorts – concurrent idiopathic pulmonary fibrosis or atypical asbestosis?

Thu, 11 Feb 2016 20:34:19 +0100

ConclusionsUsual interstitial pneumonia pattern fibrosis is rarely observed in asbestos exposed subjects, shows no dose‐response correlation with asbestos fibres on mineral analysis and this points to the alternate disease such as idiopathic pulmonary fibrosis. The results indicate that usual interstitial pneumonia pattern fibrosis should not be regarded as bonafide asbestosis, irrespective of the status of asbestos biomarkers and this impacts upon the post mortem handling of asbestos related deaths.This article is protected by copyright. All rights reserved. (Source: Histopathology)



Assessment of asbestos exposure during a simulated agricultural activity in the proximity of the former asbestos mine of Balangero, Italy

Thu, 11 Feb 2016 00:00:00 +0100

Publication date: 5 May 2016 Source:Journal of Hazardous Materials, Volume 308 Author(s): Francesco Turci, Sergio Enrico Favero-Longo, Claudia Gazzano, Maura Tomatis, Laura Gentile, Massimo Bergamini The natural occurrence of asbestos (NOA) in rural areas is a serious concern for human health and the dispersion route of asbestos in the proximity of natural asbestos-rich settings has been marginally evaluated so far. NOA may affect air, but also water and soil quality. In rural areas population may be exposed to asbestos with a largely unknown impact on human health. This work investigates the potential exposure of a farmer cultivating a field nearby the largest former asbestos mine of Western Europe (Balangero, Italy). The concentration of waterborne asbestos in the stream used to ...



Imaging of mesothelioma of tunica vaginalis testis

Wed, 10 Feb 2016 09:19:42 +0100

Conclusions A preoperative diagnosis of mesotheliomas presenting as solid paratesticular masses seems very difficult with imaging. On the contrary, the diagnosis must be considered in patients in whom a hydrocele with parietal vegetations is detected, especially if these show high vascularity. Key Points • Mesotheliomas of the tunica vaginalis are rare, often challenging to diagnose preoperatively. • Most common finding is a complex hydrocele with hypervascular parietal vegetations. • Septated hydrocele, nodules without hydrocele, a thick-walled paratesticular cyst are less common. • Preoperative diagnosis may allow aggressive surgical approach and, possibly, a better pr...



Radiation‐induced mesothelioma among long‐term solid cancer survivors: a longitudinal analysis of SEER database

Wed, 10 Feb 2016 00:00:00 +0100

Abstract We investigated the association between external beam radiotherapy (EBRT) and pleural and peritoneal mesothelioma among long‐term (>5 years) solid cancer survivors. We analyzed data from the US Surveillance, Epidemiology, and End Results (SEER) program (1973–2012). We fitted survival models adjusted by age, gender, race, year, surgery, and relative risk of primary mesothelioma in the county of residence (proxy for individual asbestos exposure). We estimated hazard ratios [HR] with reference to nonirradiated patients. We distinguished between scattered and direct irradiation to study the dose–response. We observed 301 mesotheliomas (265 pleural; 32 peritoneal; 4 others) among 935,637 patients. EBRT increased the risk of mesothelioma (any site; HR 1.34, 95% CI 1.04–1.77)...

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