Last Build Date: Tue, 22 Mar 2016 08:28:58 +0100
Mon, 21 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Mon, 21 Mar 2016 00:00:00 +0100ConclusionS‐PEecl is a distinct entity from NS‐PEecl and is mainly associated with the presence of antiβ2GP1 IgG. Antiβ2GP1 domain I correlates with other aPL IgG tests, and aPS/PT may be promising in patients for whom LA tests cannot be interpreted. (Source: Journal of Thrombosis and Haemostasis)
Mon, 21 Mar 2016 00:00:00 +0100(Source: Journal of Thrombosis and Haemostasis)
Sat, 19 Mar 2016 00:00:00 +0100We report a case of a 34year old woman with antiphospholipid antibody syndrome and SLE, who presented with mitral valve regurgitation. The patient underwent a prosthetic mitral valve replacement, with no followup complications. We suggest mechanical valve replacement employment in the management of mitral regurgitation in Libman–Sacks endocarditis, in view of the recent medical literature and our own case report. (Source: Journal of the Saudi Heart Association)
Sat, 19 Mar 2016 00:00:00 +0100Publication date: Available online 19 March 2016 Source:Reumatología Clínica (English Edition) Author(s): Aida Galicia-López, Juan Carlos Anda-Garay, Maximiliano García de la Peña (Source: Reumatologia Clinica)
Fri, 18 Mar 2016 23:15:02 +0100Conclusion Although aPLs is frequently associated with SLE and is a causative factor for thrombosis, the optimal cut-off value for aPL for predicting the occurrence of THEs varies among different underlying diseases. PMID: 26984073 [PubMed - in process] (Source: Internal Medicine)
Fri, 18 Mar 2016 23:15:02 +0100Authors: Yasuda S PMID: 26984068 [PubMed - in process] (Source: Internal Medicine)
Fri, 18 Mar 2016 11:45:28 +0100Pediatric patients with systemic lupus erythematosus may have greater odds for developing thrombosis if they have a history of vasculitis, antiphospholipid antibody positivity (aPL), and/or avascular... (Source: Rheumatology News)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: APL levels decreased marginally during pregnancy, and changes were not associated with pregnancy outcome. Our findings suggest that measurement of aPL early is sufficient to assess risk . Repeat aPL testing through pregnancy is unnecessary. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Thu, 17 Mar 2016 00:00:00 +0100In this report we will review the clinical and laboratory diagnostic criteria and the management of patients with antiphospholipid syndrome. (Source: Journal of Clinical Pathology)
Wed, 16 Mar 2016 00:00:00 +0100ConclusionsCofactor‐independent aPL can induce thrombosis in vivo. This effect is mainly mediated by leukocyte activation, which depends on the previously described signal transduction via endosomal NOX2. Because most APS patients have been shown to harbor aPL with similar activity, our data are of general relevance for the APS. (Source: Journal of Thrombosis and Haemostasis)
Tue, 15 Mar 2016 00:00:00 +0100Although the data from primary antiphospholipid syndrome (APS) suggests a beneficial effect of rituximab usage, its therapeutic role remains to be defined in systemic lupus erythematosus (SLE)-associated APS, a complex clinical situation with thrombotic events and lupus activity. (Source: Seminars in Arthritis and Rheumatism)
Tue, 15 Mar 2016 00:00:00 +0100Authors: Naderi M, Tabibian S, Shamsizadeh M, Dorgalaleh A Abstract Miscarriage and recurrent miscarriage have not been reported in women with congenital factor V (FV) deficiency. Here we describe cases of both miscarriage and recurrent miscarriage in women with congenital FV deficiency (FVD). We investigated six women with FVD from the southeast of Iran who had experienced miscarriage and recurrent miscarriage. Consequent diagnosis was made by routine coagulation tests as well as FV activity and antigen assays. To evaluate the presence of an inhibitor, a mixing study via prothrombin time (PT) assay was performed. All patients were investigated, and found to be negative for antiphospholipid syndrome. Demographic data and clinical presentations were obtained by standard questionnair...
Mon, 14 Mar 2016 00:16:06 +0100Authors: Peiró P, Prieto-González S, de la Red G, Espinosa G PMID: 26961401 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Mon, 14 Mar 2016 00:16:06 +0100Authors: Ardila-Suarez O, Gómez-Puerta JA, Khamashta MA PMID: 26961394 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Mon, 14 Mar 2016 00:00:00 +0100ConclusionsWe demonstrated that A1‐A1, which is a soluble analog of ApoER2 that binds pathological β2GPI/anti‐β2GPI complexes, has a positive impact on hemodynamics in lupus‐prone mice with spontaneous anti‐β2GPI antibodies and hypertension.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Mon, 14 Mar 2016 00:00:00 +0100Abstract We evaluated the importance of anti-annexin A5 antibodies (aanxA5 Abs) for clinical (thrombosis and/or recurrent pregnancy loss) and serologic (presence of antiphospholipid antibodies: lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2 glycoprotein I (aβ2GPI) antibodies) features of patients with primary antiphospholipid syndrome (PAPS). Our study included 70 patients with PAPS according to the international consensus criteria for APS. The mean age of the analyzed patients was 45.97 ± 12.72. The disease duration above 5 years was present in 31/70 of patients. Concentrations of analyzed antibodies were measured by ELISA. Cutoff values were set in accordance to the manufacturers’ recommendations. History of recurrent pregnancy loss was associated with do...
Mon, 14 Mar 2016 00:00:00 +0100CONCLUSION: Our study of pSLE patients suggests that vasculitis, positive APL, and AVN are associated with thrombotic events in this population. PMID: 26980741 [PubMed - as supplied by publisher] (Source: Lupus)
Mon, 14 Mar 2016 00:00:00 +0100CONCLUSIONS: We demonstrated that A1-A1, which is a soluble analog of ApoER2 that binds pathological β2GPI/anti-β2GPI complexes, has a positive impact on hemodynamics in lupus-prone mice with spontaneous anti-β2GPI antibodies and hypertension. This article is protected by copyright. All rights reserved. PMID: 26990752 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Sat, 12 Mar 2016 18:35:07 +0100Abstract To compare the levels of IgG and IgM anti beta-2 glycoprotein I antibodies and IgG and IgM anti prothrombin antibodies among women with unexplained recurrent pregnancy losses and women with at least 2 live issues. To compare the prevalence of newer anti beta-2 glycoprotein I & anti prothrombin antibodies with conventional Lupus anticoagulant & anticardiolipin antibodies. 50 women with recurrent pregnancy losses & 50 matched controls were evaluated for the presence of: Lupus anticoagulant—screened by LA sensitive aPTT& DRVV and confirmatory Staclot Assay. ELISA kits were used for detecting IgG & IgM anticardiolipin, anti beta-2 glycoprotein I & anti prothrombin antibodies. 11/50 (22 %) women in study group and none in control group had circula...
Sat, 12 Mar 2016 00:00:00 +0100Abstract The Japanese Dermatological Association prepared guidelines focused on the treatment of skin ulcers associated with connective tissue disease/vasculitis practical in clinical settings of dermatological care. Skin ulcers associated with connective tissue diseases or vasculitis occur on the background of a wide variety of diseases including, typically, systemic sclerosis but also systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid arthritis (RA), various vasculitides and antiphospholipid antibody syndrome (APS). Therefore, in preparing the present guidelines, we considered diagnostic/therapeutic approaches appropriate for each of these disorders to be necessary and developed algorithms and clinical questions for systemic sclerosis, SLE, dermatomyositis, RA, vasculitis an...
Fri, 11 Mar 2016 21:35:02 +0100CONCLUSION: Systolic longitudinal and diastolic performance impairments are frequent findings in SLE patients without overt cardiovascular disease. Cumulative organ damage, disease duration, APS, and hypertension are major determinants for early heart involvement in SLE patients. PMID: 26962554 [PubMed - in process] (Source: Medical Ultrasonography)
Fri, 11 Mar 2016 00:00:00 +0100Authors: Rutter-Locher Z, Chen Z, Flores L, Basu T, Creamer D, Weeks R, Arya R, Nashef L Abstract A 51-year-old man gave a 2-year history of worsening mobility, cognitive decline and headaches. He had a history of thromboembolic stroke, recurrent transient ischaemic attacks and a spontaneous intraventricular haemorrhage. On examination, he had livedo reticularis and perniosis and a systolic murmur. Catheter cerebral angiography showed peripheral small-vessel and medium-vessel vasculopathy resulting in pruning of the distal cortical vessels and tortuous irregular distal collaterals. Skin biopsy showed subtle vasculopathy with ectasia of capillaries and postcapillary venules but no frank vasculitis or arterial thrombosis. Repeated serum antiphospholipid antibody titres were negative....
Mon, 07 Mar 2016 00:00:00 +0100ConclusionsEndometritis and elevated inflammatory and autoimmune markers are common in women with RPL/RIF, but endometritis cannot be predicted based on either peripheral inflammatory or autoimmune markers. (Source: American Journal of Reproductive Immunology)
Sat, 05 Mar 2016 09:07:21 +0100Conclusion The rare association of severe or catastrophic APS with cryoglobulinemia in patients should be considered by physicians who treat patients with multi-organ ischemia or necrosis. (Source: Revista Brasileira de Reumatologia)
Fri, 04 Mar 2016 00:00:00 +0100CONCLUSIONS: Compared to controls, both aPL+ and SLE patients had elevated cortical activation, primarily in the frontal lobes, during tasks of working memory and executive function. These findings are consistent with cortical over‐activation as a compensatory mechanism for early white matter neuropathology in these disorders. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Thu, 03 Mar 2016 00:00:00 +0100CONCLUSION: A clinically significant aPL profile is associated with an increased risk of organ damage accrual during a 15-year follow-up in SLE patients. PMID: 26945023 [PubMed - as supplied by publisher] (Source: Lupus)
Mon, 29 Feb 2016 00:00:00 +0100Abstract Thrombotic manifestations of antiphospholipid syndrome (APS) are well known, and various non-stroke neuro-psychiatric manifestations (NPMs) have also been consistently described, but their place in APS remains unclear. Some syndromes, such as migraine or cognitive dysfunction, are frequently described in APS, whereas others, like seizure, multiple sclerosis-like symptoms, transverse myelitis, movement disorders, or psychiatric symptoms, are rarely found. Overlap with other autoimmune diseases, in particular with systemic lupus erythematosus, the lack of large sample size prospective studies, and discrepancies in antiphospholipid antibody (aPL) determinations complicate the study of the relationship between those disorders and aPL/APS. This review article aimed to summari...
Sat, 27 Feb 2016 11:19:58 +0100Abstract: Bariatric procedures are an effective option for weight loss and control of comorbidities in obese patients. Obesity is a proinflammatory condition in which some cytokines such as leptin, a proinflammatory protein, is elevated and adiponectin, an anti-inflammatory protein, is decreased. In patients undergoing weight reduction surgeries, these hormone levels behave paradoxically. It is not known whether bariatric surgery protects against development of autoinflammatory or autoimmune conditions; nevertheless, changes occurring in the immune system are incompletely understood. In this case series, we describe 4 patients undergoing bariatric surgery, who subsequently developed systemic autoimmune diseases. Patients in our case series were asymptomatic before surgery and developed an ...
Thu, 25 Feb 2016 14:20:07 +0100No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Wed, 24 Feb 2016 00:00:00 +0100ConclusionApoER2 plays a major role in the attenuation of trophoblast function by aPL, and the receptor mediates aPL‐induced pregnancy complications in vivo in mice. ApoER2‐directed interventions can now potentially be developed to combat the pregnancy complications associated with APS. (Source: Arthritis and Rheumatism)
Tue, 23 Feb 2016 00:00:00 +0100Conclusion The rare association of severe or catastrophic APS with cryoglobulinemia in patients should be considered by physicians who treat patients with multi-organ ischemia or necrosis. (Source: Revista Brasileira de Reumatologia)
Mon, 22 Feb 2016 00:00:00 +0100Conclusion: ASTRO-APS will be the largest prospective study to date comparing a direct oral anticoagulant with warfarin among patients with APS for the secondary prevention of thrombosis. Our inclusion criteria assure that outcomes obtained will be clinically applicable to the routine management of patients with APS receiving indefinite anticoagulation. (Source: Clinical and Applied Thrombosis/Hemostasis)
Sat, 20 Feb 2016 00:00:00 +0100Acute limb ischemia results from sudden deterioration in the arterial supply to the limb, occasionally leading to limb loss or fatality. Antiphospholipid syndrome (APS) is known to induce acute limb ischemia among the various etiologies responsible for arterial obstruction. APS is a systemic autoimmune disorder characterized by a combination of arterial and/or venous thrombosis and limb loss. It is often accompanied by a mild-to-moderate thrombocytopenia and elevated titers of antiphospholipid antibodies, including the lupus anticoagulant and the anticardiolipin antibodies. (Source: Journal of Foot and Ankle Surgery)
Fri, 19 Feb 2016 11:27:02 +0100CONCLUSION: Ischemic parenchymal changes are characterized by hepatocyte K7 immunoexpression, sinusoidal capillarization, HSC activation and lack of cellular proliferation, indicating an early reaction of the major liver parenchyma cellular components creating a more resistant microenvironment. These phenotypic alterations may prove valuable in the discrimination of ischemic liver lesions. PMID: 26887669 [PubMed - as supplied by publisher] (Source: Histology and Histopathology)
Fri, 19 Feb 2016 00:00:00 +0100Publication date: Available online 19 February 2016 Source:The Journal of Foot and Ankle Surgery Author(s): Kiwako Suzuki, Tetsuji Uemura, Mamoru Kikuchi, Yasuhiro Ishihara, Shigeru Ichioka Acute limb ischemia results from sudden deterioration in the arterial supply to the limb, occasionally leading to limb loss or fatality. Antiphospholipid syndrome (APS) is known to induce acute limb ischemia among the various etiologies responsible for arterial obstruction. APS is a systemic autoimmune disorder characterized by a combination of arterial and/or venous thrombosis and limb loss. It is often accompanied by a mild-to-moderate thrombocytopenia and elevated titers of antiphospholipid antibodies, including the lupus anticoagulant and the anticardiolipin antibodies. In the present report,...
Thu, 18 Feb 2016 06:09:02 +0100Authors: Ambrosino P, Lupoli R, Di Minno A, Iervolino S, Peluso R, Di Minno MN Abstract Several studies reported on the association between antiphospholipid syndrome (APS) and venous thrombosis. In contrast, little is known about cardiovascular (CV) risk in APS. We performed a meta-analysis on the impact of APS on major markers of CV risk. Studies on the relationship between APS and common carotid artery intima-media thickness (CCA-IMT), internal carotid artery IMT (ICA-IMT), carotid bifurcation IMT (BIF-IMT), prevalence of carotid plaques, flow-mediated dilation (FMD), nitrate-mediated dilation (NMD), and ankle-brachial index (ABI) were systematically searched in PubMed, Web of Science, Scopus, and EMBASE databases. Twenty case-control studies (668 cases, 678 controls) were includ...
Wed, 17 Feb 2016 14:27:02 +0100Authors: Forastiero R, Martinuzzo M Abstract Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by clinical symptoms of vascular thrombosis and/or pregnancy morbidity in the presence of autoimmune antiphospholipid antibodies (aPL). Current laboratory APS criteria include the presence of at least one of the three relevant aPL: lupus anticoagulant, anticardiolipin antibodies and anti-β2 glycoprotein I antibodies. Therefore, patients could have a single aPL pattern or combinations of aPL. Evidence arising from clinical experience indicates that patients having the highest aPL titer and simultaneous aPL detected by different tests have a worse prognosis and a higher probability of recurrence of the APS clinical features. In recent years, an emerging role of multip...
Wed, 17 Feb 2016 14:22:02 +0100CONCLUSIONS: Our study demonstrates the lack of association between the presence of SADs and mutations in exon 5 of the TMEM173 gene. SADs are complex multifactorial diseases in which not just one but probably many different genetic alterations may coexist. Although we cannot rule out the possibility that other variations may exist in other regions of this gene, we think that studies must be directed towards the analysis of other genes which, as TMEM173, also code for nucleic acid sensors that activate the nucleic-acid induced type I IFN pathway. PMID: 26593864 [PubMed - in process] (Source: Autoimmunity)
Wed, 17 Feb 2016 14:22:02 +0100Authors: McIntyre JA, Ramsey CJ, Gitter BD, Saykin AJ, Wagenknecht DR, Hyslop PA, Alzheimer’s Disease Neuroimaging Initiative Abstract A robust blood biomarker is urgently needed to facilitate early prognosis for those at risk for Alzheimer's disease (AD). Redox reactive autoantibodies (R-RAAs) represent a novel family of antibodies detectable only after exposure of cerebrospinal fluid (CSF), serum, plasma or immunoglobulin fractions to oxidizing agents. We have previously reported that R-RAA antiphospholipid antibodies (aPLs) are significantly decreased in the CSF and serum of AD patients compared to healthy controls (HCs). These studies were extended to measure R-RAA aPL in serum samples obtained from Alzheimer's Disease Neuroimaging Initiative (ADNI). Serum samples from the AD...
Wed, 17 Feb 2016 14:22:02 +0100CONCLUSIONS: In young stroke patients with APS, serum levels of IgM aCL within 48 h are correlated with stroke severity and levels of IgG anti-β2GPI within 48 h are correlated with three-month outcomes. PMID: 25434364 [PubMed - in process] (Source: Autoimmunity)
Wed, 17 Feb 2016 14:22:02 +0100We report that, although high affinity pathological anti-β2GPI antibodies were produced in all groups of animals, the reproductive pathology was recorded only in mice that received both LPS and TTd, implying on the important roles of both infections and molecular mimicry in APS pathogenesis. Moreover, APS-related reproductive pathology was more pronounced in BALB/c (lowered fertility and fecundity) than C57BL/6 mice (lowered fecundity), which correlated well with the disruption in natural antibody network observed in BALB/c mouse strain. PMID: 25430703 [PubMed - indexed for MEDLINE] (Source: Autoimmunity)
Tue, 16 Feb 2016 00:00:00 +0100STUDY QUESTION What is the association between daily preconception-initiated low-dose aspirin (LDA) treatment and very early pregnancy losses or euploid (chromosomally normal) losses among women with one to two prior losses? SUMMARY ANSWER Daily LDA initiated preconception was not associated with the rate or type of pregnancy loss among women with a history of one to two prior pregnancy losses. WHAT IS KNOWN ALREADY LDA is often used to treat recurrent pregnancy loss with reductions in pregnancy loss generally only observed among women with antiphospholipid antibodies, and null associations observed among women without antiphospholipid antibodies. We previously evaluated the association between LDA and pregnancy loss overall among women with one to two prior losses in the Effects of Aspi...
Mon, 15 Feb 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. PMID: 26879261 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Sun, 14 Feb 2016 13:08:47 +0100Maria Gerosa, Barbara Poletti, Francesca Pregnolato, Gabriella Castellino, Annalisa Lafronza, Vincenzo Silani, Piersandro Riboldi, Pier Luigi Meroni, Joan T. Merrill (Source: Frontiers in Immunology)
Sat, 13 Feb 2016 13:31:02 +0100CONCLUSIONS: This paper provides an overview of facts and emergency situations which can be encountered in the care of patients with autoimmune systemic diseases and vasculitides. It is directed at clinicians working in intensive care. It provides a differential diagnostic overview and information which is rare and commonly underestimated. PMID: 26868300 [PubMed - as supplied by publisher] (Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub)
Fri, 12 Feb 2016 18:00:00 +0100(MedPage Today) -- But lack of reversal agents for some complicates the picture (Source: MedPage Today Cardiovascular)
Thu, 11 Feb 2016 00:00:00 +0100This study aimed to investigate the activation of B cells from TLR4-defective (C3H/HeJ) and TLR4-intact (C3H/HeN) mice pre-immunized with human β2GPI. After β2GPI injection, the level of anti-β2GPI antibody in the serum of TLR4-defective and TLR4-intact mice was gradually increased and the number and size of germinal centers in the spleen were also significantly increased. Compared with C3H/HeJ mice, we observed significantly higher anti-β2GPI antibody titer and more germinal centers in C3H/HeN mice. Moreover, the β2GPI-induced expression of CD40L, CD40, CD80, CD86 and MHC II in C3H/HeN mice was significantly higher than that in C3H/HeJ mice. Furthermore, the β2GPI-induced expression of B cell activating factor (BAFF) in the spleen and IL-6 and IL-10 in B cells from C3H/HeN mice was ...
Thu, 11 Feb 2016 00:00:00 +0100In conclusion, plasma DRVVTr and FNG are strong predictors of vascular mortality in PAPS; while FNG lowering agents exist further research should be directed at therapeutic strategies able to dampen aPL production. PMID: 26864875 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Tue, 09 Feb 2016 00:00:00 +0100Conclusions Preconceptual TAC is more successful in preventing repeat spontaneous mid-trimester loss and preterm labour, and is associated with less surgical and pregnancy-related morbidity compared to first trimester TAC insertion. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Fri, 05 Feb 2016 14:37:41 +0100This week's question involves antiphospholipid syndrome. Osmosis (Source: Medscape Today Headlines)
Fri, 05 Feb 2016 00:00:00 +0100CONCLUSIONS: By guidelines, all laboratories are strongly advised to validate/verify the manufacturer's cutoff values. We recommend establishing low-positive, medium-/high-positive, and high-positive CliA IgG aCL and a-β2GpI ranges in order to help clinicians in the diagnosis and treatment of APS. PMID: 26847159 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Thu, 04 Feb 2016 00:00:00 +0100Conclusions. Antiphospholipid antibody syndrome with valvular vegetations in acute Q fever is a new clinical entity. This would suggest the value of systematically testing for C. burnetii in antiphospholipid-associated cardiac valve disease, and performing early echocardiography and antiphospholipid dosages in patients with acute Q fever. (Source: Clinical Infectious Diseases)
Thu, 04 Feb 2016 00:00:00 +0100Nature Reviews Rheumatology 12, 132 (2016). doi:10.1038/nrrheum.2016.13 Author: Caroline Barranco Lupus anticoagulant antiphospholipid antibodies (aPL) are confirmed as a risk factor for adverse pregnancy outcomes (preterm delivery, neonatal or fetal death, and low birth weight). This prior PROMISSE finding has now been validated in an independent group of 44 women recruited subsequently. Lupus anticoagulant was (Source: Nature Reviews Rheumatology)
Mon, 01 Feb 2016 00:00:00 +0100We read with interest the recent paper “A new cytofluorimetric approach to evaluate the circulating microparticles in subjects with antiphospholipid antibodies” on Thrombosis Research by Niccolai et al. about a new approach for the evaluation of microparticles (MPs) by flow cytometry . (Source: Thrombosis Research)
Mon, 01 Feb 2016 00:00:00 +0100ConclusionsBy guidelines, all laboratories are strongly advised to validate/verify the manufacturer's cutoff values. We recommend establishing low‐positive, medium‐/high–positive, and high‐positive CliA IgG aCL and a‐β2GpI ranges in order to help clinicians in the diagnosis and treatment of APS. (Source: Clinical and Laboratory Haematology)
Fri, 29 Jan 2016 00:00:00 +0100Conclusions: We suggest that, in patients with RVO, hyperhomocysteinemia and antiphospholipid syndrome should be ruled out. Moreover, a study of genetic thrombophilia should only be considered in those aged <50 years or without cardiovascular risk factors. Antiplatelet therapy with aspirin is probably the treatment of choice of RVO, to reduce the overall vascular risk. Anticoagulation should only be considered in patients with high-risk thrombophilia. (Source: QJM)
Thu, 28 Jan 2016 13:36:02 +0100CONCLUSIONS These results confirm that triple aPL positivity has strong association with APS, and indicate that the identification of triple antibody positive patients is platform independent. The findings suggest that when aPL antibody profiles are considered, agreement between various methods is improved compared to agreement at the level of individual antibodies. PMID: 26810938 [PubMed - as supplied by publisher] (Source: Polskie Archiwum Medycyny Wewnetrznej)
Thu, 28 Jan 2016 00:00:00 +0100Authors: Terrisse AD, Laurent PA, Garcia C, Gratacap MP, Vanhaesebroeck B, Sié P, Payrastre B Abstract Antiphospholipid syndrome (APS) is an autoimmune disease characterised by the presence of antiphospholipid antibodies (aPL) associated with increased thrombotic risk and pregnancy morbidity. Although aPL are heterogeneous auto-antibodies, the major pathogenic target is the plasma protein β2-glycoprotein 1. The molecular mechanisms of platelet activation by aPL remain poorly understood. Here, we explored the role of the class IA phosphoinositide 3-kinase (PI3K) α and β isoforms in platelet activation by aPL. Compared to control IgG from healthy individuals, the IgG fraction isolated from patients with APS potentiates platelet aggregation induced by low dose of thrombin in vitro...
Wed, 27 Jan 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Tue, 26 Jan 2016 04:20:04 +0100CONCLUSION: aPL auto antibodies are more prevalent in ABD. Any clinical association should be further determined. PMID: 25812700 [PubMed - indexed for MEDLINE] (Source: Human Antibodies)
Tue, 26 Jan 2016 04:20:04 +0100Authors: Roye-Green K, Frederick J, Wharfe G, Choo-Kang E, DaCosta V, Fletcher H, Smikle M Abstract Blood samples from 50~women who had had recurrent spontaneous abortions and 135 healthy multiparous women were investigated for anticardiolipin (aCL) antibodies and anti-β₂ Glycoprotein 1 (anti-β₂ GP1) dependent aCL antibodies by enzyme-linked immunosorbent assays (ELISA), lupus anticoagulant activity was measured by activated partial thromboplastin time, antinuclear antibodies, rheumatoid factors and thyroid antibodies using standard techniques. Serological tests for syphilis were performed on all sera and thyroid function was evaluated. There was no significant difference in the prevalence of autoantibodies in habitual aborters and control subjects (60% and 44%, respectively)...
Tue, 26 Jan 2016 00:00:00 +0100This article provides a comprehensive and critical review of the literature on the epidemiology, pathophysiology, diagnosis, and management of NPSLE. We describe the most common pharmacological treatments used in NPSLE, based on both a literature search and our expert opinion. The extent to which new drugs in the advanced development of SLE, or the blockade of new targets, may impact future treatment of NPSLE will also be discussed. (Source: Drugs)
Sun, 24 Jan 2016 00:00:00 +0100Conclusion Careful monitoring of pregnancy and efficient treatment of SLE can decrease the risks for the mother and the fetus. However, despite improvements in pregnancy outcome of SLE pregnant patients, adverse maternal and fetal outcomes may occur. SLE may flare-up with pregnancy. (Source: Middle East Fertility Society Journal)
Fri, 22 Jan 2016 13:38:27 +0100(MedPage Today) -- Lupus anticoagulant was the only antiphospholipid antibody linked with poor birth outcome (Source: MedPage Today OB/GYN)
Thu, 21 Jan 2016 00:00:00 +0100Publication date: Available online 19 January 2016 Source:Indian Journal of Rheumatology Author(s): Sanjukta Rao, Mary K. George, Vineeta Shobha, G.R.K. Sarma Systemic lupus erythematosus and myasthenia gravis are autoimmune disorders whose association in the same patient has been rarely reported. An account of three cases of SLE and myasthenia coexisting in the same patients is being presented with a review of currently available literature. Case 1 was a 33-year-old female fulfilling 6 SLICC classification criteria for SLE. She developed diplopia, dysphagia, and hoarseness of voice. A CT thorax done for evaluation of pulmonary hypertension showed thymic enlargement and serum anti-acetylcholine receptor antibody was positive. The patient was treated with pyridostigmine for myasthenia...
Thu, 21 Jan 2016 00:00:00 +0100Publication date: Available online 21 January 2016 Source:Autoimmunity Reviews Author(s): Gian Domenico Sebastiani, Annamaria Iuliano, Luca Cantarini, Mauro Galeazzi Studies on the immunogenetic predisposition to antiphospholipid syndrome (APS) and on other non genetic and epigenetic factors are summarised and discussed. Family studies suggest a genetic predisposition to APS. It appears that this genetic predisposition is in part accounted for by the HLA system, the most consistent associations being those with DR4 and DRw53. Furthermore, it appears that lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are both associated with the same HLA antigens. Population studies suggest that HLA genes have a role in conferring susceptibility to develop primary APS, with some differ...
Thu, 21 Jan 2016 00:00:00 +0100(Source: Blood)
Wed, 20 Jan 2016 03:30:09 +0100This report describes one the first cases of antiphospholipid syndrome and Libman-Sacks endocarditis in a bioprosthetic valve. A redo mitral valve replacement was carried out owing to early deterioration of the prior valve. Initially it was considered secondary to rheumatic heart disease; however, pathology analysis and autoimmune workup revealed antiphospholipid syndrome with Libman-Sacks endocarditis. We believe certain populations with mitral valve stenosis may have an underlying antiphospholipid syndrome. As a result, there needs to be a lower threshold for identifying this disease. PMID: 26777966 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Wed, 20 Jan 2016 00:00:00 +0100ConclusionsCofactor independent aPL can induce thrombosis in vivo. This effect is mainly mediated by leukocyte activation which depends on the previously described signal transduction via endosomal NOX2. Since most APS patients have been shown to harbor aPL with similar activity, our data are of general relevance for the APS.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Wed, 20 Jan 2016 00:00:00 +0100CONCLUSIONS: Cofactor independent aPL can induce thrombosis in vivo. This effect is mainly mediated by leukocyte activation which depends on the previously described signal transduction via endosomal NOX2. Since most APS patients have been shown to harbor aPL with similar activity, our data are of general relevance for the APS. This article is protected by copyright. All rights reserved. PMID: 26786324 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Mon, 18 Jan 2016 00:00:00 +0100ConclusionS‐PEecl is a distinct entity from NS‐PEecl and is mainly associated with the presence of antiβ2GP1 IgG. Antiβ2GP1 domain I correlate with other aPL IgG tests, and aPS/PT may be promising in patients in which LA tests cannot be interpreted.This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Mon, 18 Jan 2016 00:00:00 +0100CONCLUSION: S-PEecl is a distinct entity from NS-PEecl and is mainly associated with the presence of antiβ2GP1 IgG. Antiβ2GP1 domain I correlate with other aPL IgG tests, and aPS/PT may be promising in patients in which LA tests cannot be interpreted. This article is protected by copyright. All rights reserved. PMID: 26782635 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Fri, 15 Jan 2016 00:00:00 +0100Abstract Antiphospholipid syndrome (APS) affects young patients in the most productive years of their life, and the consequences of organic or tissue damage involve a decrease in health-related quality of life (HRQoL). While acute disease manifestations of APS are well known, information on the long-term prognosis and damage in affected patients is still very limited. Systemic lupus erythematosus (SLE) patients would be expected to experience long-term complications and even die as a consequence of APS. Organ damage in APS has been evaluated using different methods and definitions, including the SLICC/ACR Damage Index (SDI), which tend to underestimate aPL-related damage. A new damage index in APS has been proposed (DIAPS), and it seems to be more accurate than SDI. Given the imp...
Tue, 12 Jan 2016 00:00:00 +0100Conclusion AXa activity is strongly correlated with ACT, and therefore may be feasible for managing anticoagulation with UFH during ECC.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: The Thoracic and Cardiovascular Surgeon)
Tue, 12 Jan 2016 00:00:00 +0100Conclusion AXa activity is strongly correlated with ACT, and therefore may be feasible for managing anticoagulation with UFH during ECC. PMID: 26757210 [PubMed - as supplied by publisher] (Source: The Thoracic and Cardiovascular Surgeon)
Mon, 11 Jan 2016 00:00:00 +0100This study aims to identify risk factors for thrombosis in patients with systemic lupus erythematosus (SLE) and to validate the efficacy of the partial antiphospholipid (aPL) score for thrombosis prediction and diagnosis of antiphospholipid syndrome (APS). This study included 325 SLE patients, 188 of whom completed a follow-up of 31.01 months (range 23–48 months). Partial aPL score was calculated by adding up the individual scores for activated partial thromboplastin time (APTT), lupus anticoagulant, IgG/IgM anticardiolipin antibodies (aCL), and IgG/IgM anti-β2-glycoprotein I (anti-β2GPI). A simplified aPL score was developed using only APTT, IgG/IgM aCL, and IgG/IgM anti-β2GPI. Partial aPL scores were significantly higher in SLE patients with thrombosis (p < 0.0001). A histo...
Fri, 08 Jan 2016 00:00:00 +0100(Source: Arthritis and Rheumatism)
Fri, 08 Jan 2016 00:00:00 +0100(Source: Arthritis and Rheumatism)
Fri, 08 Jan 2016 00:00:00 +0100(Source: Arthritis and Rheumatism)
Wed, 06 Jan 2016 00:00:00 +0100CONCLUSIONS: Despite not being the standard treatment in APS, we propose DOACs as a rational alternative for the management of patients with this diagnosis. Further interventional clinical studies are necessary for possible standardization of this therapy in APS patients. PMID: 26743321 [PubMed - as supplied by publisher] (Source: Lupus)
Mon, 04 Jan 2016 00:00:00 +0100Neuromyelitis optica (NMO) and its spectrum disorders (NMOSD) are autoimmune water channelopathies that predominantly target astrocytes (resulting in secondary demyelination) and are associated with the highly specific serum biomarker and pathogenic autoantibody, aquaporin-4-IgG (AQP4-IgG) . Longitudinally extensive transverse myelitis (LETM) with MRI lesions spanning ≥3 vertebral segments is a characteristic feature of NMO/NMOSD . (Source: Journal of the Neurological Sciences)
Fri, 01 Jan 2016 06:00:00 +0100In this study, we investigated the levels of coagulation factor VIII (FVIII), FIX and FXI in north Indian patients with VTE. A total of 123 patients with VTE were screened prospectively for FVIII, FIX and FXI levels and the conventional risk factors – deficiencies of protein C, S and antithrombin, positivity for antiphospholipid antibodies and the factor V Leiden mutation. Age-matched and sex-matched controls were included. VTE was secondary to known circumstantial and thrombophilic risk factors in 66 (53.7%) patients. In 46.3% (idiopathic VTE) patients, no cause was identified. The mean FVIII levels in idiopathic (187 IU/dl) and secondary VTE patients (185.4 IU/dl) were significantly higher compared with controls (129.6 IU/dl; P (Source: Blood Coagulation and Fibrinolysis)
Fri, 01 Jan 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: Journal of Thrombosis and Haemostasis)
Fri, 01 Jan 2016 00:00:00 +0100We present the case ofa26-year-old female who presented to the hospital with pneumococcal meningitis. A review of her records showed atrophic spleen, and a hypercoagulable workup was positive for Systemic Lupus Erythematous (SLE)/Antiphospholipid Antibody Syndrome (APS). An autosplenectomy from thrombotic occlusion of the splenic artery made her susceptible to pneumococcal meningitis. Autoimmune conditions, particularly SLE and APS, are important causes of hypercoagulable states in a young population, and earlier detection of these conditions and appropriate treatment helps to decrease morbidity and mortality among these patients. PMID: 26882790 [PubMed - in process] (Source: Connecticut Medicine)
Sat, 26 Dec 2015 00:00:00 +0100Authors: Rao AN, Kazzaz NM, Knight JS Abstract Thrombotic events, both arterial and venous, are a major health concern worldwide. Further, autoimmune diseases, such as systemic lupus erythematosus, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and antiphospholipid syndrome, predispose to thrombosis, and thereby push the risk for these morbid events even higher. In recent years, neutrophils have been identified as important players in both arterial and venous thrombosis. Specifically, chromatin-based structures called neutrophil extracellular traps (NETs) play a key role in activating the coagulation cascade, recruiting platelets, and serving as scaffolding upon which the thrombus can be assembled. At the same time, neutrophils and NETs are emerging as important...
Fri, 25 Dec 2015 06:06:53 +0100This study demonstrates that G‐β2GPI is a target antigen of humoral immune response in patients with APS, suggesting that β2GPI glycation products may contain additional epitopes for anti‐β2GPI reactivity. Searching for these antibodies may be useful for evaluating the risk of clinical manifestations. This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Thu, 24 Dec 2015 00:00:00 +0100This study demonstrates that G-β2 GPI is a target antigen of humoral immune response in patients with APS, suggesting that β2 GPI glycation products may contain additional epitopes for anti-β2 GPI reactivity. Searching for these antibodies may be useful for evaluating the risk of clinical manifestations. This article is protected by copyright. All rights reserved. PMID: 26702877 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
Mon, 21 Dec 2015 00:00:00 +0100Publication date: Available online 27 November 2015 Source:Journal of Microbiology, Immunology and Infection Author(s): Tai-Chin Hsieh, Po-Ren Hsueh, Fang-Lan Yu, Shio-Shin Jean, Fu-Lun Chen, Tsong-Yih Ou, Wen-Sen Lee (Source: Journal of Microbiology, Immunology and Infection)
Mon, 21 Dec 2015 00:00:00 +0100In conclusion, cyclophosphamide was efficacious and led to sustained response of severe NPSLE in a cohort with long follow-up. PMID: 26692040 [PubMed - as supplied by publisher] (Source: Lupus)
Sun, 20 Dec 2015 21:07:04 +0100CONCLUSIONS: Lupus patients with APAs are more prone to develop PH, with a possibility of formation of microthrombi in the pathogenesis of PH. As regards treatment of PH, in addition of PH lowering drugs, place for anticoagulants or antiplatelet agents needs to be studied in PH with APA positive patients. PMID: 26591164 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Sun, 20 Dec 2015 21:07:04 +0100Authors: Chogle AR PMID: 26591163 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Sun, 20 Dec 2015 00:00:00 +0100Conclusion In this population of women with aPLA, who had previously had an early delivery for HD and/or SGA prior to 34 weeks gestation, combined LMWH and aspirin treatment started before 12 weeks gestation in a subsequent pregnancy did not show reduction of onset of recurrent HD either <34 weeks gestation or irrespective of gestational age, compared with aspirin alone. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Sat, 19 Dec 2015 00:00:00 +0100In this study, we also review the therapeutic possibilities in refractory cases, although the likelihood of progressing to other autoimmune diseases is low. We briefly comment on incomplete obstetric antiphospholipid syndrome, also known as antiphospholipid antibody-mediated pregnancy morbidity syndrome. (Source: Revista Clinica Espanola)
Sat, 19 Dec 2015 00:00:00 +0100Publication date: Available online 19 December 2015 Source:Autoimmunity Reviews Author(s): Guillaume Moulis, Alexandra Audemard-Verger, Laurent Arnaud, Cécile Luxembourger, François Montastruc, Amelia Maria Gaman, Elisabet Svenungsson, Marco Ruggeri, Matthieu Mahévas, Mathieu Gerfaud-Valentin, Andres Brainsky, Marc Michel, Bertrand Godeau, Maryse Lapeyre-Mestre, Laurent Sailler Immune thrombocytopenia (ITP) is an autoimmune disorder leading to bleeding . However, a higher risk of thrombosis has been demonstrated in these patients [2–7]. Antiphospholipid antibodies (aPL) are common in ITP, but their role for the occurrence of ITP-related thrombosis is controversial. We performed a systematic review and a meta-analysis to investigate the risk of thrombosis associated...
Sat, 19 Dec 2015 00:00:00 +0100To examine whether combined treatment with low-molecular-weight heparin (LMWH) and aspirin reduces recurrent hypertensive disorders of pregnancy (HD: pre-eclampsia, eclampsia or HELLP syndrome) in women with antiphospholipid antibodies (aPLA) and a previous delivery for HD and/or small-for-gestational-age (SGA) birthweight before 34 weeks gestation. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Fri, 18 Dec 2015 19:59:08 +0100Conclusion: This case report illustrates the rapid sequential venous and arterial ocular thrombosis in a patient with primary antiphospholipid syndrome. (Source: Retinal Cases and Brief Reports)
Thu, 17 Dec 2015 00:00:00 +0100Authors: Amezcua-Guerra LM PMID: 26683092 [PubMed - as supplied by publisher] (Source: Lupus)
Tue, 15 Dec 2015 00:00:00 +0100(Source: Muscle and Nerve)
Mon, 14 Dec 2015 00:00:00 +0100This study was supported in part by grant from FIS-PI11/01560 within the ‘Plan Nacional de I+D+I’ and co-funded by the ‘ISCIII-Subdirección General de Evaluación’ and the ‘Fondo Europeo de Desarrollo Regional (FEDER)’. The authors have no competing interests to disclose. TRIAL REGISTRATION NUMBER Not applicable. (Source: Human Reproduction)