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MedWorm: Ankylosing Spondylitis



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Ankylosing Spondylitis category.



Last Build Date: Tue, 22 Mar 2016 08:29:07 +0100

 



Degradation of isomerized type II collagen – A highly specific marker for joint destruction that can distinguish between different rheumatic pathologies

Sun, 20 Mar 2016 18:07:32 +0100

Purpose: Collagen isomerization is a non-enzymatical process associated with tissue aging, and changes in levels of isomerized peptide fragments may reflect unique changes during pathological conditions. The D-G sequence in the collagen type II neoepitope C2M is likely to undergo beta-isomerization over time, and may be altered in tissue turnover in diseases affecting the joint. We therefore hypothesize that pathological conditions, such as osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS), in which the anabolic/catabolic balance of cartilage is challenged, may result in altered levels between isomerized and normal collagen type II. (Source: Osteoarthritis and Cartilage)

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Health-related quality of life in patients undergoing cervicothoracic osteotomies for fixed cervicothoracic kyphosis in patients with ankylosing spondylitis

Sat, 19 Mar 2016 01:34:48 +0100

BACKGROUND CONTEXT: Ankylosing spondylitis (AS) can result in severe cervicothoracic kyphotic deformity (CTKD). Few studies have addressed the relationship between cervical osteotomy and health-related quality of life (HRQOL) scores. (Source: The Spine Journal)



Secukinumab in ankylosing spondylitis or psoriatic arthritis: Added benefit not proven

Fri, 18 Mar 2016 04:00:00 +0100

(Institute for Quality and Efficiency in Health Care) Drug manufacturer presented no relevant data and claimed no added benefit. Notable was the non-publication of literature searches and analyses. (Source: EurekAlert! - Medicine and Health)



Risk of Herpes Zoster in Auto‐immune and Inflammatory diseases: Implications for Vaccination

Fri, 18 Mar 2016 00:00:00 +0100

Conclusions: SLE, IBD and RA are associated with higher risks of HZ compared to older adults recommended for vaccination, suggesting that individuals with these conditions as young as age 40 could potentially benefit from vaccination. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)






Comment on the Recommendations by Ward et al for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis

Fri, 18 Mar 2016 00:00:00 +0100

(Source: Arthritis Care and Research)

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Assessment of Response to Treatment, Remission, and Minimal Disease Activity in Axial Psoriatic Arthritis Treated with Tumor Necrosis Factor Inhibitors.

Thu, 17 Mar 2016 23:37:01 +0100

CONCLUSION: This longitudinal observational study, based on a clinical practice setting, showed that remission and MDA are achievable targets in axPsA treated with anti-TNF. Predictors of remission and MDA were also identified. PMID: 26980581 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)



Ankylosing spondylitis: A cause of death after minor trauma

Thu, 17 Mar 2016 00:00:00 +0100

Publication date: Available online 15 March 2016 Source:Joint Bone Spine Author(s): Mehmet Gazi Boyaci, Kamil Tunay, Usame Rakip, Mustafa Karademir, Ergun Karavelioglu (Source: Joint Bone Spine)



Impact of tobacco smoking on response to tumour necrosis factor-alpha inhibitor treatment in patients with ankylosing spondylitis: results from the Danish nationwide DANBIO registry

Thu, 17 Mar 2016 00:00:00 +0100

Conclusion. In this study of TNFi-treated AS patients in clinical practice, current and previous smokers had significantly poorer patient-reported outcomes at baseline, shorter treatment adherence and poorer treatment response compared with never smokers. (Source: Rheumatology)



Patient-Reported Outcomes in Psoriatic Arthritis

Wed, 16 Mar 2016 00:00:00 +0100

Patient-reported outcome (PRO) measures are an important component to assessing disease impact and therapy response in patients with psoriatic arthritis (PsA). Overall, there are few PsA-specific PROs. Most PROs used in PsA are borrowed from other diseases (eg, rheumatoid arthritis and ankylosing spondylitis) or general population PROs. PROs are used in PsA clinical trials and in the clinical management of PsA. In this review, we discuss the most commonly used PRO in PsA, including their inclusion in composite measures. Future studies may be helpful to determine the best performing PROs in patients with PsA. (Source: Rheumatic Disease Clinics of North America)



Evaluation of the effectiveness of home based or hospital based calisthenic exercises in patients with ankylosing spondylitis.

Sun, 13 Mar 2016 07:23:02 +0100

CONCLUSION: Calisthenic exercises can be easily performed both at home and in hospital setting. In patients with AS, calisthenic exercises performed at the hospital may improve the mobility, and psychological status (anxiety). PMID: 26966823 [PubMed - as supplied by publisher] (Source: Journal of Back and Musculoskeletal Rehabilitation)

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Ultrasonographic evaluation of femoral cartilage thickness in patients with psoriatic arthritis.

Sun, 13 Mar 2016 07:23:02 +0100

CONCLUSION: Femoral cartilage thickness is similar between PsA patients and healthy controls. The femoral cartilage thickness in PsA patients is associated with disease activity, functional inadequacy, and enthesopathy scores. PMID: 26966818 [PubMed - as supplied by publisher] (Source: Journal of Back and Musculoskeletal Rehabilitation)



Expert examines secukinumab’s role in ankylosing spondylitis treatment strategies

Sat, 12 Mar 2016 16:23:26 +0100

MAUI, HAWAII – The most important development within the past year in the treatment of ankylosing spondylitis was the Food and Drug Administration approval of secukinumab (Cosentyx) as the first... (Source: Rheumatology News)



Is there a common pathogenesis in Aggressive Periodontitis & Ankylosing Spondylitis in HLA-B27 patient ?

Sat, 12 Mar 2016 00:00:00 +0100

HLA-B27 is having strong association to ankylosing spondylitis (AS) and other inflammatory diseases collectively known as seronegative spondyloarthropathy. In literature, although the evidence for association between AS and periodontitis as well as AS and HLA-B27 are there but the association of aggressive periodontitis in HLA-B27 positive patient with AS are not there. We hypothesize that there may be a common pathogenesis in aggressive periodontitis and ankylosing spondylitis in HLA-B27 patient. (Source: Medical Hypotheses)



A Retrospective Cohort Study Comparing Utilization and Costs of Biologic Therapies and JAK Inhibitor Therapy Across Four Common Inflammatory Indications in Adult US Managed Care Patients

Sat, 12 Mar 2016 00:00:00 +0100

Conclusion One-year treatment costs varied considerably between medications and indications. Some newly approved agents had lower costs but further research is needed to confirm these estimates as more patients are treated. Funding Immunex (a wholly owned subsidiary of Amgen Inc.) and Wyeth (acquired by Pfizer). (Source: Advances in Therapy)



Backfill is a specific sign of axial spondyloarthritis seen on MRI

Fri, 11 Mar 2016 00:00:00 +0100

Conclusions We summarized the characteristics of backfill and found that backfill is a specific sign of axial SpA seen on T1SE MRI. (Source: Joint Bone Spine)

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Assessment of clinical efficacy and safety in a randomized double-blind study of etanercept and sulfasalazine in patients with ankylosing spondylitis from Eastern/Central Europe, Latin America, and Asia

Fri, 11 Mar 2016 00:00:00 +0100

The objective of this subset analysis of the ASCEND trial was to compare the efficacy of etanercept and sulfasalazine in treating patients with AS from Asia, Eastern/Central Europe, and Latin America. A total of 287 patients, 190 receiving etanercept 50 mg once weekly and 97 receiving sulfasalazine 3 g daily, from eight countries were included in this subset analysis. Differences in disease activity and patient-reported outcomes assessing health-related quality-of-life (HRQoL) parameters in response to treatment were analyzed using the Cochran–Mantel–Haenszel test for categorical efficacy endpoints and analysis of covariance model for continuous variables. At week 16, a significantly greater proportion of patients receiving etanercept achieved ASAS20 (79.0 %) compared with patients ...



Private rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis

Thu, 10 Mar 2016 00:00:00 +0100

Conclusions The results suggest that it is the presence of rare syntenic SEC16A and MAMDC4 deletions that increases susceptibility to AxSpA in family members who carry the HLA-B*27 allele. (Source: Annals of the Rheumatic Diseases)



Novartis’ Cosentyx® superior to Stelara in delivering lasting skin clearance for psoriasis patients

Wed, 09 Mar 2016 10:49:51 +0100

Cosentyx launched as first-line systemic indication for psoriasis in UK in 2015 and recently approved for psoriatic arthritis and ankylosing spondylitis in Europe (Source: Pharmacy Europe)



Utility of DXA scanning and Risk Factors for Osteoporosis in Ankylosing Spondylitis; A Prospective Study

Wed, 09 Mar 2016 00:00:00 +0100

Conventional DXA imaging of spine and hip to measure bone mineral density (BMD) has limitations in patients with ankylosing spondylitis (AS). We investigated the correlation of hip and spine BMD measurements in patients with AS to determine if hip DXA will prove clinically useful while avoiding the confounding effect of spinal disease. Also, we studied risk factors for osteoporosis (OP) and osteopenia in AS. (Source: Seminars in Arthritis and Rheumatism)



Characterization of ankylosing spondylitis and rheumatoid arthritis using 1 H NMR-based metabolomics of human fecal extracts

Tue, 08 Mar 2016 00:00:00 +0100

Conclusion The metabolome variations in feces indicated AS and RA were two homologous diseases that could not be distinguished by 1H NMR metabolomics. (Source: Metabolomics)

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Compensatory modulation for severe global sagittal imbalance: significance of cervical compensation on quality of life in thoracolumbar kyphosis secondary to ankylosing spondylitis

Tue, 08 Mar 2016 00:00:00 +0100

Conclusion Notable cervical compensation exists in AS patients with thoracolumbar kyphosis. The cervical compensation responsive to global imbalance was mediated by T1 slope. AS patients with hyperlordotic cervical spine present with better QOL than patients with kyphotic cervical spine. (Source: European Spine Journal)



Biologics for the treatment of autoimmune renal diseases

Mon, 07 Mar 2016 00:00:00 +0100

Nature Reviews Nephrology 12, 217 (2016). doi:10.1038/nrneph.2016.18 Authors: Stephen R. Holdsworth, Poh-Yi Gan & A. Richard Kitching Biological therapeutics (biologics) that target autoimmune responses and inflammatory injury pathways have a marked beneficial impact on the management of many chronic diseases, including rheumatoid arthritis, psoriasis, inflammatory bowel disease, and ankylosing spondylitis. Accumulating data suggest that a growing number of renal diseases result from (Source: Nature Reviews Nephrology)



Genetic Markers in a Medieval Case of Ankylosing Spondylitis.

Sun, 06 Mar 2016 00:17:05 +0100

Authors: Laza IM, Hervella M, DE-LA-Rúa C PMID: 26932994 [PubMed - in process] (Source: Journal of Rheumatology)



Assessment of Serum Uric Acid in Young Male Patients with Ankylosing Spondylitis.

Sun, 06 Mar 2016 00:17:05 +0100

Authors: Dogan T, Agilli M PMID: 26932992 [PubMed - in process] (Source: Journal of Rheumatology)



Serum Vascular Endothelial Growth Factor Levels Lack Predictive Value in Patients with Active Ankylosing Spondylitis Treated with Golimumab.

Sun, 06 Mar 2016 00:17:05 +0100

CONCLUSION: Serum VEGF did not predict radiographic progression/spinal inflammation in patients receiving antitumor necrosis factor. PMID: 26932345 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)

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Quality of life in spondyloarthritis: analysis of a large Brazilian cohort

Sat, 05 Mar 2016 09:07:21 +0100

Conclusion: In this large series of patients with SpA, female gender and African-Brazilian ethnicity, as well as predominant axial symptoms, were associated with impaired quality of life. (Source: Revista Brasileira de Reumatologia)



Ankylosing Spondylitis: Data Support 6-Month Trial of TNFisAnkylosing Spondylitis: Data Support 6-Month Trial of TNFis

Thu, 03 Mar 2016 12:00:16 +0100

The effect of TNF inhibitors on ankylosing spondylitis reached maximum efficacy and stabilized only after 6 months of treatment, twice the time recommended in widely followed guidelines. Medscape Medical News (Source: Medscape Medical News Headlines)



Radiographic progression in patients with ankylosing spondylitis according to tumor necrosis factor blocker exposure: Observation Study of Korean Spondyloarthropathy Registry (OSKAR) data

Thu, 03 Mar 2016 00:00:00 +0100

Conclusion Our registry data showed that TNF blocker failed to affect the radiographic progression over 5 years in AS patients. (Source: Joint Bone Spine)



Comparative Effectiveness of Biologic Therapy Regimens for Ankylosing Spondylitis: A Systematic Review and a Network Meta-Analysis

Tue, 01 Mar 2016 06:00:00 +0100

We reported relative risks and 95% confidence intervals from direct meta-analysis and 95% credible intervals from Bayesian network meta-analysis, and ranked the treatment for outcomes. We also used Grading of Recommendations Assessment, Development and Evaluation criteria to appraise quality of evidence. Fourteen RCTs comprising 2672 active AS patients were included in the network meta-analysis. Most biologic therapy regimens were more effective than placebo regarding all the outcomes assessed, except for secukinumab and tocilizumab. No differences between biologic therapies in the treatment of AS could be found, except for the finding that infliximab 5 mg was superior to tocilizumab. Infliximab 5 mg/kg had the highest probability of being ranked the best for achieving ASAS20, whereas...



Total hip arthroplasty-related osteogenic osteosarcoma: case report and review of the literature

Tue, 01 Mar 2016 00:00:00 +0100

Conclusions The neoplastic process may be considered as an extraordinary complication of THA and might just be coincidental or the result of some derangement of the healing process in host tissue with no definitely proven hypothesis that the implants or their by-products are carcinogenic. The soluble chemical substances from the implanted prosthetic material are, at least in animals, suspected to play a vital role in the pathogenesis of the neoplastic transformation of the bone tissue. The presented case shall alert orthopedic surgeons to clinical, radiologic, and macroscopic similarities between a malignant tumor and benign lesions caused by wear debris at THA sites. At the examination of plane X-rays of patients with THA loosening, the differential diagnosis should always incl...

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If three of my brothers have ankylosing spondylitis, why does the doctor say it is not necessarily hereditary? The meaning of risk in multiplex case families with ankylosing spondylitis

Mon, 29 Feb 2016 00:00:00 +0100

Conclusions Patient's and their relatives interpretation of familial aggregation, HLAB27, heredity, and risk perception in relation with ankylosing spondylitis involves four broad interpretive units spanning from clinical symptoms to heredity and decisions made accordingly. Their thoughts and consequent decisions are often in contradiction with the medical knowledge on the role of genetic factors in ankylosing spondylitis. (Source: Chronic lllness)



Effectiveness of ultrasound treatment applied with exercise therapy on patients with ankylosing spondylitis: a double-blind, randomized, placebo-controlled trial

Mon, 29 Feb 2016 00:00:00 +0100

Abstract The aim of our study was to evaluate effectiveness of ultrasound treatment applied with exercise therapy in patients with ankylosing spondylitis. Fifty-two patients, who were diagnosed according to modified New York criteria, were aged 25–60, and have spine pain, were randomly assigned to two groups. Ultrasound (US) and exercise therapy were applied to treatment group (27); placebo US treatment and exercise therapy were applied to control group (25). Patients were evaluated before treatment, at the end of treatment, and 4 weeks after the treatment. Daily and night pain, morning stiffness, patient global assessment (PGA), doctor global assessment (DGA), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ba...



HLA-B27 allotype-specific binding and candidate arthritogenic peptides revealed through heuristic clustering of DIA-MS data.

Mon, 29 Feb 2016 00:00:00 +0100

Authors: Schittenhelm RB, Sivaneswaran S, Lim Kam Sian TC, Croft NP, Purcell AW Abstract Expression of HLA-B27 is strongly associated with ankylosing spondylitis (AS) and other spondyloarthropathies. While this is true for the majority of HLA-B27 allotypes, HLA-B*27:06 and HLA-B*27:09 are not associated with AS. These two subtypes contain polymorphisms that are ideally positioned to influence the bound peptide repertoire. The existence of disease inducing peptides (so-called arthritogenic peptides) has therefore been proposed that are exclusively presented by disease-associated HLA-B27 allotypes. However, we have recently demonstrated that this segregation of allotype-bound peptides is not the case and that many peptides that display sequence features predicted to favor binding to ...



Complete Remission of Nephrotic Syndrome Without Resolution of Amyloid Deposit After Anti–Tumor Necrosis Factor α Therapy in a Patient With Ankylosing Spondylitis

Sat, 27 Feb 2016 11:19:58 +0100

We report the histological change after tumor necrosis factor α blocker therapy in patient with amyloid A amyloidosis and nephrotic syndrome secondary to underlying ankylosing spondylitis. The patient achieved complete remission of nephrotic syndrome after 17 months of etanercept treatment. We performed the second kidney biopsy after 40 months, and there was little change in the degree of amyloid deposition in the mesangial area and capillary loops compared with the first biopsy. The interstitial inflammation and foot process effacement, however, were fully recovered. (Source: JCR: Journal of Clinical Rheumatology)



PASS Syndrome: An IL-1-Driven Autoinflammatory Disease

Sat, 27 Feb 2016 01:35:05 +0100

PASS syndrome is a rare inflammatory disease characterized by a chronic-relapsing course of pyoderma gangrenosum, acne vulgaris, hidradenitis suppurativa and ankylosing spondylitis. Here, we describe a case of a patient with spontaneously recurrent purulent skin lesions along with seronegative spondylarthritis consistent with the PASS syndrome. During his disease exacerbation, the patient displayed episodes of fever along with elevated serum levels of interleukin (IL)-1β. Skin lesions were characterized by sterile neutrophilic infiltrates and showed a rapid response to the IL-1 receptor antagonist anakinra (Kineret®) consistent with the autoinflammatory nature of this disease. However, unlike other autoinflammatory diseases such as PAPA and PAPASH, we did not find mutations in the gene P...

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Living in Pain with Ankylosing Spondylitis: A Qualitative Study.

Thu, 25 Feb 2016 05:50:02 +0100

CONCLUSIONS: Added to being asked about the quantity of pain, patients with AS should be questioned about how pain affects their lives. Such an approach can guide health care workers in planning and applying health care approaches specific to each patient. PMID: 26902427 [PubMed - as supplied by publisher] (Source: Contemporary Nurse)



Comparison of blood loss after total hip arthroplasty between ankylosing spondylitis and osteoarthritis

Thu, 25 Feb 2016 00:00:00 +0100

To compare the blood loss during primary total hip arthroplasty (THA) between ankylosing spondylitis (AS) and hip osteoarthritis (OA). (Source: The Journal of Arthroplasty)



Non-Radiographic Axial Spondyloarthritis.

Wed, 24 Feb 2016 22:20:02 +0100

Authors: Slobodin G, Eshed I Abstract The term non-radiographic axial spondyloarthritis (nrAxSpA) was coined for patients who have a clinical picture of ankylosing spondylitis (AS) but do not exhibit radiographic sacroiliitis. The ASAS classification criteria for nrAxSpA, ensuring the recruitment of homogenous study cohorts, were accepted in 2009, although the respective diagnostic criteria for daily clinical practice have not yet been developed. The clinical diagnosis should be based on the composite of clinical symptoms and signs of the disease, HLA B27 status, and magnetic resonance imaging (MRI) of sacroiliac joints. Notably, a negative MRI or HLA B27 does not exclude the diagnosis in patients with a high clinical suspicion for nrAxSpA. The prevalence of nrAxSpA is similar to t...



Comparison of continuation rates with three TNFα antagonists (adalimumab, infliximab, etanercept) in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: Retrospective 10-year study

Wed, 24 Feb 2016 00:00:00 +0100

Publication date: Available online 23 February 2016 Source:Joint Bone Spine Author(s): Benjamin Batteux, Agathe Devauchelle, Pauline Lasselin Boyard, Alice Sejourné, Patrice Fardellone, Vincent Goëb (Source: Joint Bone Spine)



Brief Report: Six‐Week Treatment of Axial Spondyloarthritis Patients With an Optimal Dose of Nonsteroidal Antiinflammatory Drugs: Early Response to Treatment in Signal Intensity on Magnetic Resonance Imaging of the Sacroiliac Joints

Wed, 24 Feb 2016 00:00:00 +0100

ConclusionOur findings indicate a high level of dropout among patients receiving full‐dose NSAID therapy in daily practice. In those who tolerated NSAID therapy, there was no clinically relevant decrease in SPARCC scores and low BASDAI50 response. However, we found a decrease in signal intensity of bone marrow edema of the SI joints as an early response to 6 weeks of optimal NSAID therapy in patients newly presenting with axial SpA. (Source: Arthritis and Rheumatism)

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IL-23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients

Wed, 24 Feb 2016 00:00:00 +0100

Advances in pathophysiology and treatment of ankylosing spondylitis (AS) was recently demonstrated. However, the effect of anti-TNF in the newly described inflammatory pathways involved pathogenesis of this di... (Source: Arthritis Research and Therapy)



Crohn’s Disease: Evolution, Epigenetics, and the Emerging Role of Microbiome-Targeted Therapies

Tue, 23 Feb 2016 00:00:00 +0100

Abstract Crohn’s disease (CD) is a chronic, systemic, immune-mediated inflammation of the gastrointestinal tract. Originally described in 1932 as non-caseating granulomatous inflammation limited to the terminal ileum, it is now recognized as an expanding group of heterogeneous diseases defined by intestinal location, extent, behavior, and systemic extraintestinal manifestations. Joint diseases, including inflammatory spondyloarthritis and ankylosing spondylitis, are the most common extraintestinal manifestations of CD and share more genetic susceptibility loci than any other inflammatory bowel disease (IBD) trait. The high frequency and overlap with genes associated with infectious diseases, specifically Mendelian susceptibility to mycobacterial diseases (MSMD), suggest that CD...



Combined Fascia Iliaca and Sciatic Nerve Block for Hip Surgery in the Presence of Severe Ankylosing Spondylitis: A Case-Based Literature Review

Sat, 20 Feb 2016 19:20:02 +0100

Conclusions: According to the literature review, general anesthesia is the most commonly performed anesthetic technique for patients with ankylosing spondylitis undergoing hip surgeries. Special intubation techniques and cautious airway management were very important for these patients. Although both general anesthesia and central neuraxial blockade pose considerable risks to the patients, this case report suggests that combined fascia iliaca block and sciatic nerve block might be a promising option. (Source: Regional Anesthesia and Pain Medicine)



Radiographic vertebral fractures develop in patients with ankylosing spondylitis during 4 years of TNF-α blocking therapy.

Fri, 19 Feb 2016 06:58:02 +0100

CONCLUSIONS: The prevalence of radiographic vertebral fractures was high in AS patients with active disease. Although clinical assessments and BMD improved significantly, new vertebral fractures still developed during 4 years of TNF-α blocking therapy. PMID: 26886385 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)



IL‐9 over‐expression and Th9 polarization characterize the inflamed gut, the synovial tissue and the peripheral blood of patients with psoriatic arthritis

Fri, 19 Feb 2016 00:00:00 +0100

Conclusions: A strong IL‐9/Th9 polarization seems to be the predominant immunological signature of patients with PsA. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)

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Surgical interventions for nephrolithiasis in ankylosing spondylitis and the general population.

Thu, 18 Feb 2016 05:22:02 +0100

CONCLUSIONS: Patients with AS have an almost three-fold increased risk of surgical intervention for kidney stones, with similar management, compared to the general population. PMID: 26389795 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Urology)



Association study of copy number variants in FCGR3A and FCGR3B gene with risk of ankylosing spondylitis in a Chinese population

Thu, 18 Feb 2016 05:07:22 +0100

Abstract Ankylosing spondylitis (AS) is a common inherited autoimmune disease. Copy number variation (CNV) of DNA segments has been found to be an important part of genetic variation, and the FCGR3A and FCGR3B gene CNVs have been associated with various autoimmune disorders. The aim of the study was to determine whether CNVs of FCGR3A and FCGR3B were also associated with the susceptibility of AS. A total of 801 individuals including 402 AS patients and 399 healthy controls were enrolled in this study. The copy numbers of FCGR3 gene (two fragments, included FCGR3A and FCGR3B) were measured by AccuCopy™ methods. Chi-square test and logistic regression model were used to evaluate association between FCGR3 gene CNVs and AS susceptibility. P values, odds ratio, and 95 % confidence ...



Determination of IL1 R2 , ANTXR2 , CARD9 , and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis

Thu, 18 Feb 2016 05:07:22 +0100

Abstract Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown origin, while both genetic and environmental factors have been demonstrated to be etiologically involved. Recent genome-wide association and replication studies have suggested that anthrax toxin receptor 2 (ANTXR2), interleukin-1 receptor 2 (IL1R2), caspase recruitment domain-containing protein 9 (CARD9), and small nuclear RNA-activating complex polypeptide 4 (SNAPC4) seem to be associated with AS pathogenesis. This case–control study was performed on 349 unrelated AS patients and 469 age- and gender-matched healthy controls, to investigate whether these non-MHC genes (IL1R2 rs2310173, ANTXR2 rs4333130, CARD9 rs4077515, and SNAPC4 rs3812571) influence the AS risk in Iranian population. ANTXR2 rs4...



Downregulation of dickkopf-1 enhances the proliferation and osteogenic potential of fibroblasts isolated from ankylosing spondylitis patients via the Wnt/β-catenin signaling pathway in vitro.

Thu, 18 Feb 2016 02:38:02 +0100

Conclusions AS fibroblasts are characterized by an imbalance between proliferation and apoptosis. DKK-1 may play a role in switching to new bone formation in AS progression. PMID: 26837533 [PubMed - as supplied by publisher] (Source: Connective Tissue Research)



Assessment of Corneal Parameters with Scheimpflug Imaging in Patients with Ankylosing Spondylitis.

Wed, 17 Feb 2016 23:34:06 +0100

CONCLUSION: The AS patients have thinner corneas compared to control subjects, which may be affected by tear disfunction and inflammatory processes. PMID: 26337454 [PubMed - as supplied by publisher] (Source: Seminars in Ophthalmology)

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Emerging drugs for the treatment of axial and peripheral spondyloarthritis.

Wed, 17 Feb 2016 17:44:02 +0100

Authors: Braun J, Kiltz U, Heldmann F, Baraliakos X Abstract INTRODUCTION: The topic under discussion is of strong relevance to the field of spondyloarthritis (SpA) because, in addition to established biological, there are new promising compounds. The reason for the review is to put all available data together to allow for an overview on recent developments and to especially inform readers about emerging drugs, biologics and small molecules in the field of SpA. AREAS COVERED: This review on new therapies in axial and peripheral SpA comprising psoriatic arthritis (PsA) shows, that, in addition to the established anti-TNF agents infliximab, etanercept, adalimumab, golimumab, certolizumab and the first biosimilar approved in the EU, there are at least two emerging biologics in the...



Immunogenicity of infliximab and adalimumab: what is its role in hypersensitivity and modulation of therapeutic efficacy and safety?

Wed, 17 Feb 2016 17:43:02 +0100

Authors: Murdaca G, Spanò F, Contatore M, Guastalla A, Penza E, Magnani O, Puppo F Abstract INTRODUCTION: TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying antirheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated diseases such as rheumatoid arthritis, Crohn's disease, ankylosing spondylitis, psoriasis and/or psoriatic arthritis, and may be administered off-label to treat disseminated granuloma annulare systemic lupus erythematosus and systemic sclerosis. There are several TNF-α inhibitors available for clinical use including infliximab, adalimumab, golimumab, certolizumab pegol and etanercept. AREAS COVERED: infliximab and adalimumab can induce the development of anti-infliximab (anti-IFX) a...



Etanercept for the treatment of non-radiographic axial spondyloarthritis.

Wed, 17 Feb 2016 14:27:02 +0100

This article reviews recent data on the efficacy and safety of etanercept and is focused on the treatment of non-radiographic axial spondyloarthritis. This article will also discuss the role of etanercept in the context of current and developing treatment options. PMID: 26788837 [PubMed - as supplied by publisher] (Source: Expert Review of Clinical Immunology)



Golimumab for the treatment of axial spondyloarthritis.

Wed, 17 Feb 2016 14:27:02 +0100

Authors: Gelfer G, Perry L, Deodhar A Abstract Axial spondyloarthritis (axSpA) is a chronic, immune-mediated inflammatory disease of the axial skeleton that includes ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). Patients with AS experience chronic pain due to sacroiliac joint and spinal inflammation, and may develop spinal ankylosing with syndesmophyte formation. Tumor necrosis factor α inhibitors (TNFi) have shown promise in the management of AS and axSpA by targeting the underlying inflammatory process, and providing symptomatic relief. Whether they alter the progression of the disease is uncertain. Golimumab is a fully human IgG1 monoclonal antibody that targets and downregulates the pro-inflammatory cytokine TNF-α. The use of golimumab h...



Analysis of clinical trials of biosimilar infliximab (CT-P13) and comparison against historical clinical studies with the infliximab reference medicinal product.

Wed, 17 Feb 2016 14:27:02 +0100

CONCLUSION: Efficacy, safety and PK data are highly comparable between CT-P13 and RMP, both in head-to-head clinical studies, and indirect comparisons with historical clinical data for RMP. PMID: 26395833 [PubMed - in process] (Source: Expert Review of Clinical Immunology)

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Effect of Systemically Used Anti-Tumor Necrosis Factor-α Medication on the Corneal Epithelium and Stroma of Patients with Ankylosing Spondylitis.

Wed, 17 Feb 2016 14:25:02 +0100

CONCLUSIONS: Anti-TNF-α medication and/or avoidance of nonsteroidal anti-inflammatory drugs could improve the thickness of both the corneal epithelium and stroma in AS patients. PMID: 26731089 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Visual Prognosis and Ocular Complications in Herpetic versus HLA-B27- or Ankylosing Spondylitis-associated Anterior Uveitis.

Wed, 17 Feb 2016 14:25:02 +0100

CONCLUSIONS: The most prominent finding was a worse visual prognosis in herpetic AU, which is probably related to higher prevalence of corneal scarring and glaucoma. In addition, herpetic AU patients have more ocular complications overall. PMID: 26133756 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layers Thickness in Ankylosing Spondylitis.

Wed, 17 Feb 2016 14:25:02 +0100

Authors: Tas A, Yolcu U, Ilhan A, Gundogan FC PMID: 26110632 [PubMed - in process] (Source: Ocular Immunology and Inflammation)



Regarding Comments by Yolcu et al. on "Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography".

Wed, 17 Feb 2016 14:25:02 +0100

Regarding Comments by Yolcu et al. on "Evaluation of Choroidal Thickness in Ankylosing Spondylitis Using Optical Coherence Tomography". Ocul Immunol Inflamm. 2015 Dec;23(6):464-5 Authors: Kola M, Kalkisim A, Karkucak M, Turk A, Capkin E, Can I, Serdar OF, Mollamehmetoglu S, Ayar A PMID: 25760919 [PubMed - in process] (Source: Ocular Immunology and Inflammation)



Interleukin-17 in systemic lupus erythematosus: A comprehensive review.

Wed, 17 Feb 2016 14:22:02 +0100

Authors: Li D, Guo B, Wu H, Tan L, Chang C, Lu Q Abstract Systemic lupus erythematosus (SLE) is a complicated autoimmune disease of multifactorial pathoaetiology. One of the most serious manifestations is lupus nephritis. The pathogenesis of SLE has not been well elucidated, but it has been reported that interleukin-17 (IL-17) and Th17 cells play important roles in the pathogenesis of SLE. IL-17A, a member of IL-17 family, amplifies the immune response by inducing the local production of chemokines and cytokines, recruiting neutrophils and monocytes, augmenting the production of autoantibodies, and aggravating the inflammation and damage of target organs such as the kidney in SLE. In recent years, several IL-17A pathway inhibitors have advanced into clinical trials, including the a...

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Biological relevance of citrullinations: diagnostic, prognostic and therapeutic options.

Wed, 17 Feb 2016 14:22:02 +0100

CONCLUSION: Current literature suggests that increased levels of citrullinated proteins are found in several if not all inflammatory diseases. In RA measurement of anti-citrullinated protein antibodies (ACPA) against citrullinated protein fragments are widely used as a prognostic biomarker. More recently, it has been indicated that levels of selected citrullinated proteins carries additional potential as biomarkers. This includes citrullinated vimentin which provide prognostic information in diseases as fibrosis and ankylosing spondylitis. In addition, recent studies suggest that inhibition of PAD is a target for treatment of diseases such as RA and cancer where proteins that are citrullinated are believed to influence the disease activity. PMID: 25520183 [PubMed - indexed for MEDLINE]...



Missed diagnosis of oesophageal perforation in ankylosing spondylitis cervical fracture: Two case reports and literature review

Wed, 17 Feb 2016 00:00:00 +0100

We present two cases of patients with AS who sustained cervical fracture dislocation and spinal cord injury. The ossified sharp fragments caused oesophageal perforation, and the delayed diagnoses had serious consequences. Oesophageal perforation should be suspected in patients with AS and cervical fracture if bone fragments are pressing against the oesophagus and a gas shadow is visible around the fracture site on computed tomography imaging. (Source: Journal of International Medical Research)



Continuous improvement of physical functioning in Ankylosing Spondylitis patients by TNF inhibitors: 3‐year follow‐up and predictors

Tue, 16 Feb 2016 00:00:00 +0100

Conclusions: Physical functioning in routinely TNFi treated AS patients improved up to 6 months and stabilized thereafter. Therefore, it would be better to extend the period of evaluation of TNFi treatment to 6 months rather than the 3 months currently used. The risk factors of long‐term physical functioning found in this study might help to identify patients‐at‐risk at an earlier stage and improve treatment strategy. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)



Clinical research activity in periodontal medicine: a systematic mapping of trial registers.

Tue, 16 Feb 2016 00:00:00 +0100

CONCLUSIONS: Periodontal medicine now constitutes an important part of clinical periodontal research. Research activity in periodontal medicine has grown continuously since the early 2000's, and exploration of registers gives a useful up-to-date snapshot of this constantly evolving field of research. This article is protected by copyright. All rights reserved. PMID: 26881700 [PubMed - as supplied by publisher] (Source: Journal of Clinical Periodontology)



Why Do Patients with Chronic Inflammatory Rheumatic Diseases Discontinue Their Biologics? An Assessment of Patients' Adherence Using a Self-report Questionnaire.

Mon, 15 Feb 2016 00:00:00 +0100

CONCLUSION: Five predictive factors of this SD were identified, which should be assessed in routine with patients with CIRD receiving biologic treatment: pain, treatment history, self-administration of injections, negative beliefs about treatment, and a lack of perceived medical and social support. PMID: 26879361 [PubMed - as supplied by publisher] (Source: J Rheumatol)

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Assessment of Fatigue in Spondyloarthritis and Its Association with Disease Activity.

Mon, 15 Feb 2016 00:00:00 +0100

CONCLUSION: Fatigue is associated with disease-related factors and mostly with SpA activity. However, the emotional component and sex may contribute to the onset of fatigue. PMID: 26879350 [PubMed - as supplied by publisher] (Source: J Rheumatol)



Etanercept Increases Bone Mineral Density in Ankylosing Spondylitis, but Does Not Prevent Vertebral Fractures: Results of a Prospective Observational Cohort Study.

Mon, 15 Feb 2016 00:00:00 +0100

CONCLUSION: This prospective longitudinal observational cohort study showed that after 2 years of ETN, BMD of the hip and spine increased significantly, but the number of patients with VFx and the severity of VFx increased as well. Besides that, radiological progression, including the thoracic spine, increased significantly. Thus, the favorable bone-preserving effect is accompanied by unfavorable outcomes on VFx and radiological damage. PMID: 26879348 [PubMed - as supplied by publisher] (Source: J Rheumatol)



New drugs recommended for ankylosing spondylitis and nr-axSpA treatment in the NHS

Mon, 15 Feb 2016 00:00:00 +0100

The National Institute for Health and Care Excellence (NICE) is a government body that decides which drugs and treatments are available on the NHS in England and Wales. A number of anti-TNF therapies have now been recommended for use within the NHS as treatments for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis (nr-axSpA). Non-radiographic axial spondyloarthritis differs from ankylosing spondylitis, as there is no X-ray evidence of structural damage, meaning it can often go unrecognised for years. New guidance issued by NICE has endorsed the therapies as options for patients who have failed to respond to other forms of treatment, opening up new avenues for those affected by the most severe forms of the disease. New recommendations The guidance recommend...



The immunogenicity of biosimilar infliximab: can we extrapolate the data across indications?

Sun, 14 Feb 2016 15:29:02 +0100

Authors: Ben-Horin S, Heap GA, Ahmad T, Kim H, Kwon T, Chowers Y Abstract Biopharmaceuticals or 'biologics' have revolutionized the treatment of many diseases. However, some patients generate an immune response to such drugs, potentially limiting clinical efficacy and safety. Infliximab (Remicade(®)) is a monoclonal antibody used to treat several immune-mediated inflammatory disorders. A biosimilar of infliximab, CT-P13 (Remsima(®), Inflectra(®)), has recently been approved in Europe for all indications in which infliximab is approved. Approval of CT-P13 was based in part on extrapolation of clinical trial data from two indications (rheumatoid arthritis and ankylosing spondylitis) to all other indications, including inflammatory bowel disease. This review discusses the validity ...



An overview of investigational new drugs for treating ankylosing spondylitis.

Sun, 14 Feb 2016 14:09:02 +0100

Authors: Wendling D Abstract INTRODUCTION: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic condition. Pharmacological treatment relies on nonsteroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs (in case of peripheral involvement) and anti-TNF agents in case of inadequate response. To date, there are no alternate options, and about 30% of the patients do not adequately respond to anti-TNF therapy. AREAS COVERED: This overview is based on recent publications and programmed studies. The author provides the reader with an overview of AS, its current management and provide details of novel insights into the disorder. From there, the authors highlight novel treatments under investigation before providing their expert opinion on the field. EXPE...

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The use of adalimumab, etanercept, golimumab and infliximab in rheumatic pathologies: variation between label dosage and real-world use.

Sat, 13 Feb 2016 13:54:02 +0100

The objective of this study is to evaluate, under the actual conditions of use, dosing patterns of adalimumab, etanercept, golimumab and infliximab in these pathologies, and compare them with the label regimens recommended, as well as evaluating the financial implications of these regimen modifications. The study population included all adult patients diagnosed with RA, PSA or AS who had been treated with adalimumab, etanercept, golimumab and infliximab for at least 6 months between 1 January 2011 and 31 December 2013. The main variable of this study was to assess the dose dispensed for drugs administered subcutaneously and the dose prepared/administered for drugs administered intravenously, and the annual costs of the treatment. A total of 5,428 episodes were included. The mean weekly dos...



Treatment patterns and annual biologic costs in US veterans with rheumatic conditions or psoriasis.

Sat, 13 Feb 2016 13:53:03 +0100

CONCLUSIONS: Infliximab has higher cost to the VHA than adalimumab or etanercept. PMID: 26337538 [PubMed - in process] (Source: Journal of Medical Economics)



Impaired response to treatment with tumour necrosis factor {alpha} inhibitors in smokers with axial spondyloarthritis

Wed, 10 Feb 2016 00:00:00 +0100

Conclusions Current smoking is associated with an impaired response to TNFi in axSpA. (Source: Annals of the Rheumatic Diseases)



Results of closing wedge osteotomy in the treatment of sagittal imbalance due to ankylosing spondylitis.

Tue, 09 Feb 2016 20:15:02 +0100

CONCLUSION: In patients with rigid sagittal spinal deformities due to ankylosing spondylitis, lumbar lordosis and sagittal balance can be obtained using PSO. PMID: 26854051 [PubMed - in process] (Source: Acta Orthopaedica et Traumatologica Turcica)



Tumour necrosis factor- inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis: a systematic review and economic evaluation, Health Technology Assessment, Vol:20, Iss:9

Tue, 09 Feb 2016 01:00:33 +0100

Authors: Corbett M, Soares M, Jhuti G, Rice S, Spackman E, Sideris E, Moe-Byrne T, Fox D, Marzo-Ortega H, Kay L, Woolacott N, Palmer S. (Source: NIHR Journals Library)

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Cross-cultural adaptation and validation of the Portuguese version of “The assessment of knowledge in ankylosing spondylitis patients by a self-administered questionnaire”

Mon, 08 Feb 2016 00:00:00 +0100

Abstract Knowledge is an important factor in patients with ankylosing spondylitis regarding the adoption of appropriate behaviours and education. The aim of this study was to culturally adapt and validate “The assessment of knowledge in ankylosing spondylitis patients by a self-administered questionnaire” for the Portuguese population with ankylosing spondylitis. The Portuguese version of “The assessment of knowledge in ankylosing spondylitis patients by a self-administered questionnaire” was administered to a sample of 180 subjects, from which 63 individuals responded. The adaptation process involved translation, back-translation and submission to a committee of experts in the area, culminating with a Portuguese version of the instrument. Next, the scale reliability a...



Gender-attributable differences in outcome of ankylosing spondylitis: long-term results from the Outcome in Ankylosing Spondylitis International Study

Mon, 08 Feb 2016 00:00:00 +0100

Conclusion. In this prospective cohort study, no gender-attributable differences in disease activity or physical function over time were found. However, radiographic damage was more severe in males. Furthermore, males had a better QoL over time. (Source: Rheumatology)



Do extra-articular manifestations influence outcome in ankylosing spondylitis? 12-year results from OASIS.

Sat, 06 Feb 2016 03:51:02 +0100

CONCLUSIONS: In this longstanding AS cohort, the presence of EAMs was not associated with functional disability, QoL or radiographic damage over time, except for IBD, which was associated with a better EuroQoL. PMID: 26843505 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)



Efficacy of cyclosporine A as monotherapy in patients with psoriatic arthritis: a subgroup analysis of the synergy study.

Fri, 05 Feb 2016 16:09:02 +0100

CONCLUSION: Cyclosporine in monotherapy confirmed its efficacy in cutaneous psoriasis and suggested to be effective also on PsA, reducing spinal and peripheral joints' signs and symptoms. PMID: 26837484 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)



Relationship of serum osteoprotegerin with arterial stiffness, preclinical atherosclerosis, and disease activity in patients with ankylosing spondylitis

Thu, 04 Feb 2016 00:00:00 +0100

We examined 60 AS patients without CV disease or risk factors and 50 healthy controls. Disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Ankylosing Spondylitis Disease Activity Score (ASDAS), whereas functional capacity was evaluated using the Bath Ankylosing Spondylitis Functional Index (BASFI). Serum OPG levels were measured with the enzyme-linked immunosorbent assay. Carotid-femoral pulse wave velocity (PWV) was used as an indicator of arterial stiffness, whereas CIMT (examined via carotid ultrasonography) was used to evaluate preclinical atherosclerosis. The mean serum OPG level, PWV, and CIMT were significantly higher in AS patients than in controls (106.7 ± 50.9 vs. 58.1 ± 12.7 pg/mL; 7.4 ± 1.8 vs. 6.2 ± ...

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Ankylosing spondylitis associated with primary aldosteronism in a middle-aged woman.

Wed, 03 Feb 2016 00:00:00 +0100

Authors: Suh YS, Kim HO, Cheon YH, Jo W, Hong J, Lee SI PMID: 26842104 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)



Spinal Fracture in Patients With Ankylosing Spondylitis: Cohort Definition, Distribution of Injuries, and Hospital Outcomes

Mon, 01 Feb 2016 06:00:00 +0100

Conclusion. More than 10% of patients had fractures in more than 1 region of the spine. There is a high risk of adverse events in this population, and 6.6% of patients died during their inpatient stay. These results provide clinicians with a better understanding of the distribution and the high morbidity and mortality of fractures in the ankylosed spine. Level of Evidence: 3 (Source: Spine)



Risk of Psychiatric Disorders following Ankylosing Spondylitis: A Nationwide Population-based Retrospective Cohort Study.

Mon, 01 Feb 2016 00:00:00 +0100

CONCLUSION: AS might increase the risk of a subsequent newly diagnosed depressive disorder, anxiety disorder, or sleep disorder, but not schizophrenia or bipolar disorder. These observations highlight the need for psychiatric evaluation and intervention for patients with AS. PMID: 26834219 [PubMed - as supplied by publisher] (Source: J Rheumatol)



Nonsteroidal Antiinflammatory Drugs for Axial Spondyloarthritis: A Cochrane Review.

Mon, 01 Feb 2016 00:00:00 +0100

CONCLUSION: High-quality evidence indicates that both traditional and COX-2 NSAID are efficacious for treating axSpA, and harms are not different from placebo in the short term. Various NSAID are equally effective. PMID: 26834216 [PubMed - as supplied by publisher] (Source: J Rheumatol)



Distinct expression of chemokine-like factor 1 in synovium of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis

Mon, 01 Feb 2016 00:00:00 +0100

This study confirms an increased but different level of CKLF1 in RA, OA and AS patients, all significantly higher than that in controls. Additionally, the significant positive correlations between CKLF1 levels and CRP/ESR in RA and between CKLF1 and ESR suggest that CKLF1 might contribute to the inflammation state and clinical symptoms in these rheumatic diseases. Further studies are required to investigate the utility of targeting specific CKLF1 for symptom control or disease modification in RA and AS. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)

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Mind body therapies in rehabilitation of patients with rheumatic diseases.

Mon, 01 Feb 2016 00:00:00 +0100

Authors: Del Rosso A, Maddali-Bongi S Abstract Mind body therapies (MBT) share a global approach involving both mental and physical dimensions, and focus on relationship between brain, mind, body and behavior and their effects on health and disease. MBT include concentration based therapies and movement based therapies, comprising traditional Oriental practices and somatic techniques. The greatest part of rheumatic diseases have a chronic course, leading to progressive damages at musculoskeletal system and causing physical problems, psychological and social concerns. Thus, rheumatic patients need to be treated with a multidisciplinary approach integrating pharmacological therapies and rehabilitation techniques, that not should only aim to reduce the progression of damages at muscul...



Investigating the effects of a multidimensional exercise program on symptoms and antiinflammatory status in female patients with ankylosing spondylitis.

Mon, 01 Feb 2016 00:00:00 +0100

CONCLUSION: We concluded that multidimensional exercise program should be taken into consideration for AS patients due to its positive effects on symptoms and antiinflammatory effects. PMID: 26850804 [PubMed - in process] (Source: Complementary Therapies in Clinical Practice)



New guidelines for treatment of ankylosing spondylitis

Mon, 01 Feb 2016 00:00:00 +0100

(Source: PharmacoEconomics and Outcomes News)



Spinal Fracture in Patients With Ankylosing Spondylitis: Cohort Definition, Distribution of Injuries, and Hospital Outcomes

Sat, 30 Jan 2016 12:04:25 +0100

Conclusion. More than 10% of patients had fractures in more than 1 region of the spine. There is a high risk of adverse events in this population, and 6.6% of patients died during their inpatient stay. These results provide clinicians with a better understanding of the distribution and the high morbidity and mortality of fractures in the ankylosed spine. Level of Evidence: 3 (Source: Spine)



IL-17 in Chronic Inflammation: From Discovery to Targeting.

Sat, 30 Jan 2016 00:00:00 +0100

Authors: Beringer A, Noack M, Miossec P Abstract Interleukin-17 (IL-17) is a cytokine which elicits protection against extracellular bacterial and fungal infections and which plays important roles in inflammation. However, when produced in excess, it contributes to chronic inflammation associated with many inflammatory and autoimmune disorders. This has made IL-17 an attractive therapeutic target. The present review describes the structure of the IL-17 family, the IL-17 receptor complex, and the cells producing IL-17. The contributions of IL-17 to disease as well as new IL-17-based treatment options are discussed. Finally, the results of IL-17 or IL-17 receptor inhibitors in clinical trials are detailed. With a fruitful outlook, drug registration has been granted for psoriasis, and...

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Real Life Experience of First Course of Anti-TNF Treatment in Ankylosing Spondylitis Patients in Brazil

Fri, 29 Jan 2016 00:00:00 +0100

Conclusion Treatment with the anti-TNF drugs adalimumab, etanercept and infliximab is effective and well tolerated in patients with AS. The improvement in disease activity, functional parameters and quality of life was sustained for 12 months. (Source: Rheumatology and Therapy)



Study shows long-term benefits of golimumab therapy for psoriatic arthritis

Fri, 29 Jan 2016 00:00:00 +0100

New research has demonstrated the potentially significant long-term benefits that golimumab therapy can provide for people with psoriatic arthritis.The international study, led by the University of California, San Diego, aimed to evaluate long-term outcomes in psoriatic arthritis patients who achieved or did not achieve minimal disease activity over five years of golimumab treatment.This placebo-controlled trial lasted 24 weeks and was followed by an open-label extension period of up to five years. Results from the study were published in the medical journal Arthritis Care and Research.It was shown that treatment with golimumab yielded significantly higher response rates in terms of achieving minimal disease activity levels compared to those on placebo at weeks 14, 24 and 52, with minimal ...



Etoricoxib in ankylosing spondylitis: is there a role for active patients refractory to traditional NSAIDs?

Thu, 28 Jan 2016 11:49:02 +0100

CONCLUSIONS: Etoricoxib provided a clear clinical improvement in around a third of patients with axial AS refractory to traditional NSAIDs. Special care should be required when deciding to start anti-TNF-α therapy; it seems reasonable to keep in mind these results of etoricoxib treatment. PMID: 26812050 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)



Suppressors of cytokine signalling in ankylosing spondylitis and their associations with disease severity, acute-phase reactants and serum cytokines.

Thu, 28 Jan 2016 11:49:02 +0100

CONCLUSIONS: The decreased SOCS1 and increased SOCS3 expression in AS PBMCs and T cells, and their correlation with patient's functional ability, acute-phase reactants and serum pro-inflammatory cytokines suggested that SOCS may participate in the pathogenesis of AS. PMID: 26812031 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)



Circulating levels of Th1 and Th2 chemokines in patients with ankylosing spondylitis.

Thu, 28 Jan 2016 00:00:00 +0100

CONCLUSION: Our results suggest that both a Th1 chemoattractant IP-10 and Th2 chemoattractants, TARC and MDC, cooperatively play a role in the development of AS. PMID: 26827189 [PubMed - as supplied by publisher] (Source: Cytokine)

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Biosimilar of Remicade Works in Ankylosing Spondylitis (CME/CE)

Wed, 27 Jan 2016 13:30:00 +0100

(MedPage Today) -- No differences in immunogenicity were observed, authors say (Source: MedPage Today Geriatrics)



Frequency of axial spondyloarthritis diagnosis among patients seen by United States rheumatologists for evaluation of chronic back pain

Wed, 27 Jan 2016 00:00:00 +0100

Conclusion Among patients with chronic back pain for ≥3 months beginning at age <45 years, the presence of ≥1 of 3 SpA features is an effective way to identify patients with possible axSpA. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)



Observed Incidence of Uveitis Following Certolizumab Pegol Treatment in Patients with Axial Spondyloarthritis

Wed, 27 Jan 2016 00:00:00 +0100

Conclusion: The rate of uveitis flares was lower for axSpA patients treated with CZP than PBO during the randomized controlled phase. Incidence of uveitis flares remained low to Wk96 and was comparable to rates reported for AS patients receiving other anti‐TNF antibodies. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)



Associations between vitamin D receptor gene polymorphisms and ankylosing spondylitis in Chinese Han population: a case–control study

Wed, 27 Jan 2016 00:00:00 +0100

Conclusions The VDR gene TaqI polymorphism G allele may be a risk factor in AS susceptibility. (Source: Osteoporosis International)