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MedWorm: Internal Medicine



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Internal Medicine



Last Build Date: Mon, 28 Mar 2016 03:13:50 +0100

 



Saphenous Vein Graft Disease and Serum Erythropoietin Level

Mon, 28 Mar 2016 01:13:11 +0100

Conclusion:Saphenous Vein Graft Disease and Serum Erythropoietin Level Saphenous Vein Graft Disease and Serum Erythropoietin Level Saphenous Vein Graft Disease and Serum Erythropoietin Level Saphenous Vein Graft Disease and Serum Erythropoietin Level Saphenous Vein Graft Disease and Serum Erythropoietin Level Saphenous Vein Graft Disease and Serum Erythropoietin Level (Source: Medical Principles and Practice)

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[Thigh cutaneous lesions].

Sun, 27 Mar 2016 15:12:02 +0100

Authors: Langlois V, Nassarmadji K, Célestin S, Tuech JJ, Bernet J, Lévesque H, Grémain V, Marie I PMID: 27016278 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)



[Adrenal insufficiency of the adult].

Sun, 27 Mar 2016 15:12:02 +0100

Authors: Jublanc C, Bruckert E Abstract Adrenal insufficiency is a rare but life-threatening disorder. Clinical manifestations include fatigue, weight loss, gastrointestinal manifestations and skin hyperpigmentation, the latter being specific of primary adrenal failure. Because of non-specific clinical features of this rare disorder, diagnosis can be delayed and adrenal failure be revealed by an acute crisis. Adrenal insufficiency can be primary (Addison disease), most frequently autoimmune, or secondary, resulting from long term administration of exogenous glucocorticoids or more rarely from pituitary disorders. Monitoring of substitutive treatment is now well codified. Patient education is very important in this chronic disease that remains associated with a persistent high risk ...



Often seen, rarely recognized: mast cell activation disease - a guide to diagnosis and therapeutic options.

Sun, 27 Mar 2016 10:13:01 +0100

Authors: Afrin LB, H Butterfield J, Raithel M, J Molderings G Abstract Mast cell (MC) disease has long been thought to be just the rare disease of mastocytosis (in various forms, principally cutaneous and systemic), with aberrant MC mediator release at symptomatic levels due to neoplastic MC proliferation. Recent discoveries now show a new view is in order, with mastocytosis capping a metaphorical iceberg now called "MC activation disease" (MCAD, i.e. disease principally manifesting inappropriate MC activation), with the bulk of the iceberg being the recently recognized "MC activation syndrome" (MCAS), featuring inappropriate MC activation to symptomatic levels with little to no inappropriate MC proliferation. Given increasing appreciation of a great menagerie of mutations in MC re...



Simeprevir or telaprevir with peginterferon and ribavirin for recurrent hepatitis C after living‐donor liver transplantation: A Japanese multicenter experience

Sat, 26 Mar 2016 23:00:00 +0100

ConclusionSimeprevir‐based triple therapy for recurrent hepatitis C after living‐donor liver transplantation resulted in a high SVR rate and good tolerability, especially in treatment‐naïve patients. (Source: Hepatology Research)



MicroRNA‐122 Regulates Polyploidization in the Murine Liver

Sat, 26 Mar 2016 11:43:44 +0100

Conclusion: Our data demonstrate that miR‐122 is both necessary and sufficient in liver polyploidization. Among the different signals that have been associated with hepatic polyploidy, miR‐122 is the first liver‐specific signal identified. These studies will serve as the foundation for future work investigating miR‐122 in liver maturation, homeostasis and disease. This article is protected by copyright. All rights reserved. (Source: Hepatology)

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Vagus nerve ultrasound in a patient with amyotrophic lateral sclerosis

Sat, 26 Mar 2016 11:43:41 +0100

(Source: Muscle and Nerve)



Reply

Fri, 25 Mar 2016 23:00:00 +0100

(Source: Hepatology)






Pain Prevalence, Socio-Demographic and Clinical Features in Patients With Chronic Ulcers

Fri, 25 Mar 2016 23:00:00 +0100

Chronic wounds are considered a worldwide epidemic and pain is the most frequently symptom referred by the patients who have this type of wound. The aim was to assess the prevalence of pain in chronic wounds and relate socio-demographic and clinical variables to pain. This is an analytical cross-sectional study, carried out in Basic Health Units (BHU), Family Health Strategy (ESF) and in a university hospital in two cities of Minas Gerais. 200 individuals who had chronic ulcers of different etiologies participated. (Source: Journal of Tissue Viability)



A Qualitative Study Of Factors Impacting Upon The Recruitment Of Participants To Research Studies In Wound Care- The Community Nurses’ Perspective

Fri, 25 Mar 2016 23:00:00 +0100

The focus of this study was to identify the factors that impact upon the recruitment of participants to research studies in wound care from the community nurses’ perspective. (Source: Journal of Tissue Viability)

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Physician Discipline Rates Vary Fourfold Between StatesPhysician Discipline Rates Vary Fourfold Between States

Fri, 25 Mar 2016 22:12:10 +0100

Discrepancies highlight the need for standardization of the disciplinary process. Medscape Medical News (Source: Medscape Medical News Headlines)



CDC updates advice on preventing sexual transmission of Zika virus

Fri, 25 Mar 2016 21:37:15 +0100

Men potentially exposed to Zika virus should use a condom during all sex or abstain from sex for at least 8 weeks, according to new recommendations from the Centers for Disease Control and Prevention... (Source: Internal Medicine News)



Gut microbiota plays undefined role in liver disease

Fri, 25 Mar 2016 18:19:42 +0100

The development and progression of fatty liver, and alcoholic and nonalcoholic diseases appear to be influenced by gut microbiota but it is too early to say whether microbial therapy could be used to... (Source: Internal Medicine News)



Terlipressin does not reverse hepatorenal syndrome but improves survival

Fri, 25 Mar 2016 18:04:26 +0100

Treating patients with hepatorenal syndrome type 1 (HRS-1) with the synthetic vasopressin analogue terlipressin (Lucassin) and albumin does not improve the chances of reversal of hepatorenal syndrome... (Source: Internal Medicine News)



Sertraline improves Cryptococcus clearance in HIV meningitis

Fri, 25 Mar 2016 16:59:22 +0100

An open-label pilot study has found adjunct treatment with the SSRI antidepressant sertraline is associated with accelerated clearance of Cryptococcus from the cerebrospinal fluid in... (Source: Internal Medicine News)



FDG‐PET detects non‐uniform muscle activity in the lower body during human gait

Fri, 25 Mar 2016 16:34:15 +0100

This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)

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A twist on the genetic link between Alzheimer’s and heart disease

Fri, 25 Mar 2016 13:30:03 +0100

Alzheimer’s disease often strikes fear in people’s hearts because it gradually erodes a person’s ability to remember, think, and learn. There is no cure, and available treatments alleviate symptoms only temporarily. An estimated 5.3 million Americans currently have Alzheimer’s disease, yet this brain disorder is far less common than heart disease. More than 85 million people in the United States are living with some form of cardiovascular disease or the after-effects of stroke, which also affects brain function. Many people don’t realize that Alzheimer’s and heart disease share a genetic link: the apolipoprotein E gene, also known as ApoE. Genetic testing for ApoE — which is done mainly in research settings and isn’t yet widely available — cannot predict whether a per...



Influence of osteoclasts and osteoprotegerin on the mode of calcific degeneration of aortic valves.

Fri, 25 Mar 2016 13:02:02 +0100

CONCLUSIONS    The presence of osteoclasts in stenotic valves associated with low circulating OPG levels and an enhanced proportion of M2 macrophages can represent a variant of calcific aortic valve disease with a specifically regulated calcification process. PMID: 27003233 [PubMed - as supplied by publisher] (Source: Polskie Archiwum Medycyny Wewnetrznej)



Difficult-to-treat asthma and dysphagia in an adult patient with aberrant right subclavian artery.

Fri, 25 Mar 2016 13:02:02 +0100

Authors: Przybyszowski M, Bochenek G, Pawlak S, Śliwka J, Pawlik W, Sładek K PMID: 27000793 [PubMed - as supplied by publisher] (Source: Polskie Archiwum Medycyny Wewnetrznej)



Polish and European management strategies in patients with atrial fibrillation. Data from the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot).

Fri, 25 Mar 2016 13:02:02 +0100

CONCLUSIONS    A rhythm control-oriented strategy in patients with AF with the use of ablation in cardiology wards is more frequent in Poland than in other EU countries. Similar to other EU countries, compliance with the ESC guidelines regarding anticoagulation in AF patients is suboptimal in Poland. Undertreatment was observed in a significant proportion of patients at high risk of stroke, while a large group of low-risk patients are overtreated. Differences between the types of recruiting centers in Poland and other EU countries might have influenced the results. PMID: 27000745 [PubMed - as supplied by publisher] (Source: Polskie Archiwum Medycyny Wewnetrznej)



Comparison of Peripapillary Choroidal Thickness Measurements via Spectral Domain Optical Coherence Tomography with and without Enhanced Depth Imaging.

Fri, 25 Mar 2016 13:00:02 +0100

CONCLUSIONS: The PP-CT measurements via SD-OCT without EDI were consistent with the measurements via SD-OCT with EDI. Ophthalmologists who do not have access to EDI technology can use images of SD-OCT without EDI to measure the peripapillary choroid for research purposes. However, thicker peripapillary choroids cannot be measured using this technique and require further modifications or newer technologies, such as SD-OCT with EDI. PMID: 27011108 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)

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Evaluation of Retinal Nerve Fiber Layer Thickness and Choroidal Thickness in Pseudoexfoliative Glaucoma and Pseudoexfoliative Syndrome.

Fri, 25 Mar 2016 13:00:02 +0100

CONCLUSIONS: Thinning of the RNFL in association with unchanged ChT may mean that the presence of PEX material is a much more significant risk factor than choroidal changes in the progression of PEX syndrome to PEX glaucoma. PMID: 27007173 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)



mHealth intervention to improve medication management in chronically ill patients: analysis of the recruitment process.

Fri, 25 Mar 2016 13:00:02 +0100

CONCLUSION: We found age to be an important barrier to smartphone use in healthcare. Among smartphone users, good adherence and sufficient routine healthcare were the most common reasons for refusal to participate. Thus, this type of intervention could enhance participation for poor adherers or caregivers. Implementing educational initiatives could play a key role in improving patient perceptions of technology. PMID: 27007065 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)



Effects of canagliflozin on body weight and body composition in patients with type 2 diabetes over 104 weeks.

Fri, 25 Mar 2016 13:00:02 +0100

CONCLUSIONS: Canagliflozin 100 and 300mg provided sustained reductions in body weight, BMI, and waist circumference in a greater proportion of patients with T2DM versus glimepiride or placebo over 104 weeks. TRIAL REGISTRATION: ClinicalTrials.gov NCT00968812, NCT01106651. PMID: 27002421 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)



The Potential Trajectory of Carbapenem-Resistant EnterobacteriaceaeThe Potential Trajectory of Carbapenem-Resistant Enterobacteriaceae

Fri, 25 Mar 2016 12:34:28 +0100

How much of a public health threat is carbapenem-resistant enterobacteriaceae, and what types of infection control practices should be put in place to help prevent it? American Journal of Epidemiology (Source: Medscape Today Headlines)



Twenty-Four Hours of Activity With Nine Wearable DevicesTwenty-Four Hours of Activity With Nine Wearable Devices

Fri, 25 Mar 2016 12:34:28 +0100

The authors assess the accuracy of various wearable devices for measuring daily activity levels. How do they compare? Medicine and Science in Sports and Exercise (Source: Medscape Today Headlines)

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Lupus patients’ transition to adult care leaves gaps, delays in care

Fri, 25 Mar 2016 11:40:19 +0100

Patients with childhood-onset systemic lupus erythematosus (SLE) who transitioned to adult care without a formal transitioning process had long periods without care despite having moderate disease... (Source: Internal Medicine News)



Oral epigallocatechin-3-gallate for treatment of dystrophic epidermolysis bullosa: a multicentre, randomized, crossover, double-blind, placebo-controlled clinical trial

Fri, 25 Mar 2016 00:00:00 +0100

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genodermatosis with severe blistering. No curative treatment is available. Scientific data indicated that epigallocatechin-3-gallate (EGCG), a green ... (Source: Orphanet Journal of Rare Diseases)



Atorvastatin and fluvastatin are associated with dose‐dependent reductions in cirrhosis and hepatocellular carcinoma, among patients with hepatitis C virus: Results from ERCHIVES

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion: In patients with chronic HCV, statin use was associated with a dose‐dependent reduction in incident cirrhosis and HCC. Atorvastatin and fluvastatin were associated with the most significant antifibrotic effects, compared with other statins. (Hepatology 2016) (Source: Hepatology)



Expression of Apoptosis‐regulating Proteins Bcl‐2 and Bax in Lymph Node Aspirates from Dogs with Lymphoma

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions and clinical importanceHigher intrinsic resistance to apoptosis following cytotoxic treatment might contribute to the less favorable prognosis associated with multicentric TCL in dogs. Whether Bcl‐2/Bax will be helpful to identify canine BCL and TCL with more aggressive and more indolent behavior, respectively, should be evaluated in larger prospective clinical studies. (Source: Journal of Veterinary Internal Medicine)

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Evaluation of Four Diagnostic Tests for Insulin Dysregulation in Adult Light‐Breed Horses

Thu, 24 Mar 2016 23:00:00 +0100

ConclusionsCurrent criteria for diagnosis of insulin resistance using BIC and the OST are highly specific but lack sensitivity. The CGIT displayed better sensitivity and specificity, but modifications may be necessary to improve agreement with minimal model analysis. (Source: Journal of Veterinary Internal Medicine)



Reply

Thu, 24 Mar 2016 23:00:00 +0100

(Source: Muscle and Nerve)



Camptocormia may be myopathic or dystonic

Thu, 24 Mar 2016 23:00:00 +0100

(Source: Muscle and Nerve)



Plasma neurofilament heavy chain is not a useful biomarker in Charcot‐Marie‐Tooth Disease

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions: Plasma NfH levels are not altered in patients with CMT and are not a suitable biomarker of disease activity. This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)



Six‐Minute Walk Test is Reliable and Valid in Spinal Muscular Atrophy

Thu, 24 Mar 2016 23:00:00 +0100

This study documents measurement properties of reproducibility, positive criterion validity, and convergent validity with established clinical assessments and reaffirms the value of the 6MWT as a pivotal outcome measure in SMA clinical trials. This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)

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Recovery of Strength is Dependent on mTORC1 Signaling after Eccentric Muscle Injury

Thu, 24 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)






Novel genetic and neuropathological insights in NARP

Thu, 24 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)



Reply

Thu, 24 Mar 2016 23:00:00 +0100

(Source: Muscle and Nerve)



Pax3+ skeletal muscle satellite cells retain long‐term self‐renewal and proliferation

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions: Pax3+/Pax7‐ SCs exhibited the ability of long‐term self‐renewal and proliferation, whereas Pax3‐/Pax7+ SCs demonstrated faster differentiation. This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)

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Hepatitis C Disease Burden in the United States in the Era of Oral Direct‐Acting Antivirals

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions: HCV‐associated disease burden will still remain substantial in the era of oral DAAs. Increasing HCV screening and treatment capacity is essential to further decreasing HCV burden in the United States. This article is protected by copyright. All rights reserved. (Source: Hepatology)



Evidence that the ABCG5/G8‐independent pathway plays a determinant role in cholesterol gallstone formation in mice

Thu, 24 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Hepatology)



Metallothionein‐1G Facilitates Sorafenib Resistance through Inhibition of Ferroptosis

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion: These findings demonstrate a novel molecular mechanism of sorafenib resistance and also suggest that MT‐1G is a new regulator of ferroptosis in HCC cells. This article is protected by copyright. All rights reserved. (Source: Hepatology)



IgG4+ B‐Cell Receptor Clones Distinguish IgG4‐Related Disease from Primary Sclerosing Cholangitis and Biliary/Pancreatic Malignancies

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion: IgG4+ BCR clones and IgG4/IgG RNA‐ratio markedly improve delineation, early diagnosis and monitoring of IgG4‐related disease of the biliary tree and pancreas. This article is protected by copyright. All rights reserved. (Source: Hepatology)



Statins and portal hypertension: A tale of two models

Thu, 24 Mar 2016 23:00:00 +0100

(Source: Hepatology)

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Assessing the Therapeutic Potential of Lab‐Made Hepatocytes

Thu, 24 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Hepatology)



Imaging in chest disease

Thu, 24 Mar 2016 23:00:00 +0100

Chest radiography (CXR) and computed tomography (CT) are among the more commonly needed imaging investigations in patients with lung disease. The CXR is often the first test requested and has the advantage of a low radiation dose. However, the utility of CXR is limited – particularly for diffuse lung diseases – and CT is then generally required. Modern CT scanners can acquire images of the thorax in a single breath-hold and provide exquisite morphological detail, but the added radiation burden should be a major consideration for physicians and radiologists alike. (Source: Medicine)



Flexible bronchoscopy

Thu, 24 Mar 2016 23:00:00 +0100

There have been dramatic advances in the field of bronchoscopy over recent years, with a multitude of standard and specialized techniques being used by bronchoscopists in the diagnosis and management of respiratory disease, particularly in lung cancer. Standard techniques universally used in respiratory departments include endobronchial and transbronchial biopsy, bronchial washing and brushing, and bronchoalveolar lavage. Specialized techniques used in the diagnosis and staging of lung cancer include endobronchial ultrasound-guided transbronchial needle aspiration and autofluorescence bronchoscopy. (Source: Medicine)



Respiratory symptoms and signs

Thu, 24 Mar 2016 23:00:00 +0100

The year 2016 marks the 200th anniversary of Laënnec's invention of the stethoscope, with the subsequent publication of auscultatory sounds for clinical diagnosis in 1819. Today, history and examination remain pivotal to accurate diagnosis. The hypotheticodeductive method of diagnosis based on Bayes' theorem requires a detailed history and examination skills to elicit symptoms and signs. The key symptoms of respiratory disease are breathlessness, chest pain, wheeze, cough and associated sputum production. (Source: Medicine)



64-Year-Old-Woman With Chest Pressure and Shortness of Breath

Thu, 24 Mar 2016 23:00:00 +0100

A 64-year-old woman presented to the emergency department with progressive dyspnea and intermittent chest pressure of a few months' duration. The patient described orthopnea, paroxysmal nocturnal dyspnea, and a 4.5-kg weight gain. She did not have fevers, chills, sore throat, productive cough, palpitations, or syncope. (Source: Mayo Clinic Proceedings)

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Menstrual Disturbances in Premenopausal Women with End-Stage Renal Disease: A Cross-Sectional Study

Thu, 24 Mar 2016 21:34:14 +0100

Conclusions: In this study, successful transplantation and NHD partially improved the symptoms of menstrual disturbances. Therefore, we recommend that further studies are necessary to confirm our finding in ESRD patients.Med Princ Pract (Source: Medical Principles and Practice)



Arterial calcium findings on mammograms can predict heart disease risk

Thu, 24 Mar 2016 21:00:00 +0100

Findings that are easily visible on mammograms – but never shared with patients – could be employed as a powerful new tool for cardiovascular risk assessment, a study showed. In this prospective... (Source: Internal Medicine News)



Brain imaging suggests link between stress and cardiovascular events

Thu, 24 Mar 2016 21:00:00 +0100

Stress seems to be a strong driver of cardiovascular events, including heart attack, stroke, and even death. For the first time, brain imaging has confirmed a link that has long been suspected:... (Source: Internal Medicine News)



Heart attack patients getting younger, fatter, and less healthy

Thu, 24 Mar 2016 21:00:00 +0100

Despite advances in the prevention and early detection of cardiovascular disease, heart attack patients are getting younger, fatter, and less health conscious. A look at 10 years’ worth of patient... (Source: Internal Medicine News)



Randomized corporate clinical trials

Thu, 24 Mar 2016 19:10:07 +0100

The randomized clinical trial (RCT) has been the bulwark of the development of effective and safe medical and surgical therapy. Developed over the last half-century, they have proved the benefit and... (Source: Internal Medicine News)



Prevent back pain like a pro athlete

Thu, 24 Mar 2016 16:03:14 +0100

Whether you're a corporate desk jockey or a major league baseball player, chances are you've experienced back pain that impacted job performance. It's one of the most common reasons for missing work, and according to a report recently published in JAMA Internal Medicine, more than 80% of us will experience at least one bout of acute low back pain in our lifetimes. Many will face a recurrence within the first year. (Source: CNN.com - Health)

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A 47-year-old Man with Peripheral Edema

Thu, 24 Mar 2016 15:15:15 +0100

VIDEO: Note marked tumescence in patient’s hands, pitting edema in lower extremities. Does PMH contribute? Dx? (Source: ConsultantLive)



TEDMED Talk: Why Doctors Kill Themselves

Thu, 24 Mar 2016 12:51:21 +0100

At TEDMED, medicine's version of TEDTalks, Dr Pam Wible talks in earnest about physician suicide--and how to stop it. (Source: ConsultantLive)



Corrigendum to 'A rare case of fibrostenotic endobronchial tuberculosis of trachea' [Ann. Med. Surg. 4 (2015) 479-482].

Thu, 24 Mar 2016 10:23:02 +0100

Authors: Cary C, Jhajj M, Cinicola J, Evans R, Cheriyath P, Gorrepati VS Abstract [This corrects the article DOI: 10.1016/j.amsu.2015.10.007.]. PMID: 27006765 [PubMed - as supplied by publisher] (Source: Annals of Medicine)



Long‐term effects of very low‐carbohydrate and high‐carbohydrate weight‐loss diets on psychological health in obese adults with type 2 diabetes: randomized controlled trial

Thu, 24 Mar 2016 02:43:08 +0100

ConclusionIn obese adults with T2DM, both diets achieved substantial weight loss and comparable improvements in QoL, mood state and affect. These results suggest that either an LC or HC diet within a lifestyle modification programme that includes exercise training improves psychological well‐being. (Source: Journal of Internal Medicine)



TIME Impact – a new user-friendly tuberculosis (TB) model to inform TB policy decisions

Thu, 24 Mar 2016 00:00:00 +0100

Tuberculosis (TB) is the leading cause of death from infectious disease worldwide, predominantly affecting low- and middle-income countries (LMICs), where resources are limited. As such, countries need to be a... (Source: BMC Medicine)



Survey of healthcare experiences of Australian adults living with rare diseases

Thu, 24 Mar 2016 00:00:00 +0100

This study explores the experiences of Australian adults living with rare diseases in relation to diagn... (Source: Orphanet Journal of Rare Diseases)



Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes

Thu, 24 Mar 2016 00:00:00 +0100

Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte medi... (Source: Orphanet Journal of Rare Diseases)



Ten years of specialized adult care for phenylketonuria – a single-centre experience

Thu, 24 Mar 2016 00:00:00 +0100

Specialized adult care of phenylketonuria (PKU) patients is of increasing importance. Adult outpatient clinics for inherited errors of metabolism can help to achieve this task, but experience is limited. Ten y... (Source: Orphanet Journal of Rare Diseases)



Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients

Thu, 24 Mar 2016 00:00:00 +0100

We retrospectively compared biochemical responses in type 1 Gaucher disease patients to treatment with glycosphingolipid synthesis inhibitors miglustat and eliglustat and ERT. (Source: Orphanet Journal of Rare Diseases)

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Global Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982–2012: A Systematic Analysis

Wed, 23 Mar 2016 23:00:00 +0100

by Kathryn E. Lafond, Harish Nair, Mohammad Hafiz Rasooly, Fátima Valente, Robert Booy, Mahmudur Rahman, Paul Kitsutani, Hongjie Yu, Guiselle Guzman, Daouda Coulibaly, Julio Armero, Daddi Jima, Stephen R. C. Howie, William Ampofo, Ricardo Mena, Mandeep Chadha, Ondri Dwi Sampurno, Gideon O. Emukule, Zuridin Nurmatov, Andrew Corwin, Jean Michel Heraud, Daniel E. Noyola, Radu Cojocaru, Pagbajabyn Nymadawa, Amal Barakat, Adebayo Adedeji, Marta von Horoch, Remigio Olveda, Thierry Nyatanyi, Marietjie Venter, Vida Mmbaga, Malinee Chittaganpitch, Tran Hien Nguyen, Andros Theo, Melissa Whaley, Eduardo Azziz-Baumgartner, Joseph Bresee, Harry Campbell, Marc-Alain Widdowson, Global Respiratory Hospitalizations—Influenza Proportion Positive (GRIPP) Working Group Background The global burden of pedi...



MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1α expression

Wed, 23 Mar 2016 23:00:00 +0100

MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1α expression Cell Death and Disease 7, e2159 (March 2016). doi:10.1038/cddis.2016.27 Authors: C Lou, M Xiao, S Cheng, X Lu, S Jia, Y Ren & Z Li (Source: Cell death and disease)



Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation

Wed, 23 Mar 2016 23:00:00 +0100

Authors: H J Lee, J M Ryu, Y H Jung, K H Lee, D I Kim & H J Han (Source: Cell death and disease)



ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells

Wed, 23 Mar 2016 23:00:00 +0100

Authors: N Luo, J Guo, L Chen, W Yang, X Qu & Z Cheng (Source: Cell death and disease)



miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma

Wed, 23 Mar 2016 23:00:00 +0100

miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma Cell Death and Disease 7, e2156 (March 2016). doi:10.1038/cddis.2016.64 Authors: Y Liu, R Zhao, H Wang, Y Luo, X Wang, W Niu, Y Zhou, Q Wen, S Fan, X Li, W Xiong, J Ma, X Li, M Tan, G Li & M Zhou (Source: Cell death and disease)

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Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy

Wed, 23 Mar 2016 23:00:00 +0100

Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy Cell Death and Disease 7, e2155 (March 2016). doi:10.1038/cddis.2016.62 Authors: D W L Wong, W H Yiu, H J Wu, R X Li, Y Liu, K W Chan, J C K Leung, L Y Y Chan, K N Lai & S C W Tang (Source: Cell death and disease)



GW627368X inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signaling

Wed, 23 Mar 2016 23:00:00 +0100

GW627368X inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signaling Cell Death and Disease 7, e2154 (March 2016). doi:10.1038/cddis.2016.61 Authors: S Parida, I Pal, A Parekh, B Thakur, R Bharti, S Das & M Mandal (Source: Cell death and disease)



Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation

Wed, 23 Mar 2016 23:00:00 +0100

Authors: C Wang, C Qu, Y Alippe, S L Bonar, R Civitelli, Y Abu-Amer, M O Hottiger & G Mbalaviele (Source: Cell death and disease)



Sodium–hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility

Wed, 23 Mar 2016 23:00:00 +0100

Sodium–hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility Cell Death and Disease 7, e2152 (March 2016). doi:10.1038/cddis.2016.65 Authors: Su-Ren Chen, M Chen, S-L Deng, X-X Hao, X-X Wang & Y-X Liu (Source: Cell death and disease)



Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α

Wed, 23 Mar 2016 23:00:00 +0100

Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α Cell Death and Disease 7, e2151 (March 2016). doi:10.1038/cddis.2016.56 Authors: F Ren, L Zhang, X Zhang, H Shi, T Wen, L Bai, S Zheng, Y Chen, D Chen, L Li & Z Duan (Source: Cell death and disease)

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Hospital air: A potential route for transmission of infections caused by β-lactam–resistant bacteria

Wed, 23 Mar 2016 23:00:00 +0100

Conclusions The results revealed that hospital air is a potential route of transmission of BLRB, such as Acinetobacter and Staphylococcus, 2 important causative agents of nosocomial infections. Therefore, improvement of control measures against the spreading of airborne bacteria in hospital environments is warranted. (Source: American Journal of Infection Control)



Higher levels of function before hip fracture tied to greater fears of falling at 1 year

Wed, 23 Mar 2016 21:28:23 +0100

WASHINGTON – Fear of falling at 12 weeks was associated with poorer functional recovery up to 1 year after hip fracture, particularly if the person had a high level of function before the fracture, a... (Source: Internal Medicine News)



Incretin-based diabetes drugs don’t raise heart failure risk

Wed, 23 Mar 2016 21:00:00 +0100

Incretin-based antidiabetic drugs didn’t raise the risk of hospitalization for heart failure in an international observational study involving 1.5 million patients reported online March 24 in the New... (Source: Internal Medicine News)



Voluntary self-disclosure: Pros and cons of using the protocol

Wed, 23 Mar 2016 20:58:42 +0100

AUSTIN, TEX. – Using the federal government’s voluntary self-disclosure protocol to report potential program violations offers advantages and disadvantages. On one hand, the protocol allows health... (Source: Internal Medicine News)



FDA approves reslizumab as add-on drug for adults with severe asthma

Wed, 23 Mar 2016 20:44:23 +0100

The U.S. Food and Drug Administration has approved the use of reslizumab with other asthma medication for maintenance treatment in adult patients with a history of severe asthma attacks. The drug is... (Source: Internal Medicine News)



Cardiac Rehab Goes Better With Added Stress ManagementCardiac Rehab Goes Better With Added Stress Management

Wed, 23 Mar 2016 19:31:22 +0100

Patients in cardiac rehabilitation programs may have fewer complications when the training includes stress management, a recent study suggests. Reuters Health Information (Source: Medscape Medical News Headlines)

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Observation might be best in advanced-stage, low-grade ovarian CA

Wed, 23 Mar 2016 17:58:07 +0100

SAN DIEGO – Surgery, chemotherapy, and radiation do not prolong survival in advanced-stage but low-grade papillary serous ovarian cancer, according to a review of 1,159 low-grade cases in the... (Source: Internal Medicine News)



Does sharing genetic risk change behavior?

Wed, 23 Mar 2016 17:07:16 +0100

In the era of individualized (or precision) medicine, we are presented with a unique opportunity to peer into the genetic “maps” of our patients. Through this window, we can envision the self-evident... (Source: Internal Medicine News)



VIDEO: Medication reconciliation can improve patient outcomes

Wed, 23 Mar 2016 16:46:17 +0100

SAN DIEGO – Prescription medications are a major contributor to unnecessary health care spending. According to data from the Centers for Medicare & Medicaid Services, retail spending on... (Source: Internal Medicine News)

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Idarucizumab may reverse dabigatran anticoagulation in intracranial hemorrhage

Wed, 23 Mar 2016 16:28:31 +0100

LOS ANGELES – It only took a few minutes for idarucizumab to normalize blood-clotting parameters in 18 patients with dabigatran-associated intracranial hemorrhages, according to interim results from... (Source: Internal Medicine News)



Expert shares recipe for being a great ward attending

Wed, 23 Mar 2016 16:20:46 +0100

SAN DIEGO – According to Dr. Jeffrey Wiese, one intangible trait to being an effective ward attending involves establishing and maintaining expectations for your team. “As much as my life has been... (Source: Internal Medicine News)



Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.

Wed, 23 Mar 2016 13:39:28 +0100

This systematic review and meta-analysis of 19 trials included 44,989 participants,  with 2496 major cardiovascular events were recorded during a mean 3·8 years of follow-up.  Patients in the more intensive blood pressure-lowering treatment group had mean blood pressure levels of 133/76 mm Hg, compared with 140/81 mm Hg in the less intensive treatment group. Intensive blood pressure-lowering treatment achieved RR reductions for major cardiovascular events (14% [95% CI 4-22]), myocardial infarction (13% [0-24]), stroke (22% [10-32]), albuminuria (10% [3-16]), and retinopathy progression (19% [0-34]). However, more intensive treatment had no clear effects on heart failure (15% [95% CI -11 to 34]), cardiovascular death (9% [-11 to 26]), total mortality (9% [-3 to 19])...



Lifetime HIV infection risk declines, but some still at high risk

Wed, 23 Mar 2016 12:02:47 +0100

BOSTON – The risk that a person living in the United States will become infected with HIV in his or her lifetime is declining compared with a decade ago, but the risk remains quite high among blacks... (Source: Internal Medicine News)



Femoral Pseudoaneurysm as a Complication of Infective Endocarditis

Wed, 23 Mar 2016 07:34:28 +0100

(Source: Journal of General Internal Medicine)






“Doctor, My Chest is on Fire”

Wed, 23 Mar 2016 07:34:28 +0100

(Source: Journal of General Internal Medicine)



The Modified, Multi-patient Observed Simulated Handoff Experience (M-OSHE): Assessment and Feedback for Entering Residents on Handoff Performance

Wed, 23 Mar 2016 07:34:28 +0100

CONCLUSIONS The M-OSHE is a promising strategy for teaching and evaluating entering residents’ ability to give verbal handoffs of multiple patients. Prior training and more handoff experience was associated with higher performance, which suggests that additional handoff training in medical school may be of benefit. (Source: Journal of General Internal Medicine)

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Cotton Fever: Does the Patient Know Best?

Wed, 23 Mar 2016 07:34:28 +0100

We present a case of a 22-year-old woman with fever and leukocytosis that were presumed secondary to cotton fever, a rarely recognized complication of injection drug use, after an extensive workup. Cotton fever is a benign, self-limited febrile syndrome characterized by fevers, leukocytosis, myalgias, nausea and vomiting, occurring in injection drug users who filter their drug suspensions through cotton balls. While this syndrome is commonly recognized amongst the injection drug user population, there is a paucity of data in the medical literature. We review the case presentation and available literature related to cotton fever. (Source: Journal of General Internal Medicine)



Defining Appropriate Use of Proton-Pump Inhibitors Among Medical Inpatients

Wed, 23 Mar 2016 07:34:28 +0100

CONCLUSIONS For the majority of medical inpatients outside the ICU, use of PPIs likely leads to a net increase in hospital mortality. Even in patients at particularly high risk of UGIB, only those at the very lowest risk of HCAP and CDI should be considered for prophylactic PPI use. Continuation of outpatient PPIs may also increase expected hospital mortality. Apart from patients with active UGIB, use of PPIs in hospitalized patients should be discouraged. (Source: Journal of General Internal Medicine)



[Headaches of unusual cause].

Wed, 23 Mar 2016 03:27:02 +0100

Authors: El Aoud S, Mnif F, Cheikhrouhou N, Mnif Feki M, Rekik N, Hajkacem F, Charfi N, Abid M PMID: 26997160 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)



[Comprehensive geriatric assessment (CGA) in elderly with cancer: For whom?]

Wed, 23 Mar 2016 03:27:02 +0100

Authors: Liuu E, Caillet P, Curé H, Anfasi N, De Decker L, Pamoukdjian F, Canouï-Poitrine F, Soubeyran P, Paillaud E, sous l’égide de la Société francophone d’oncogériatrie (SoFOG) Abstract Scientific societies recommend the implementation of a comprehensive geriatric assessment (CGA) in cancer patients aged 70 and older. The EGA is an interdisciplinary multidimensional diagnostic process seeking to assess the frail older person in order to develop a coordinated plan of treatment and long-term follow-up. Identification of comorbidities and age-induced physiological changes that may increase the risk of anticancer treatment toxicities is essential to better assess the risk-benefit ratio in elderly cancer patients. The systematic implementation of a CGA for each patient is ...



Rationing tests for drug-resistant tuberculosis – who are we prepared to miss?

Wed, 23 Mar 2016 00:00:00 +0100

Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission. Resource-constrained settings use risk profiling to ration t... (Source: BMC Medicine)



Clinical use of whole genome sequencing for Mycobacterium tuberculosis

Wed, 23 Mar 2016 00:00:00 +0100

Drug-resistant tuberculosis (TB) remains a major challenge to global health and to healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of which 1.4 % were multidrug-resistant ... (Source: BMC Medicine)



World TB Day 2016: an interview with leading experts in tuberculosis research

Wed, 23 Mar 2016 00:00:00 +0100

In this interview, we talk to leading tuberculosis (TB) experts from University College London and the London School of Hygiene and Tropical Medicine about the current challenges in TB research. The video of t... (Source: BMC Medicine)

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