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MedWorm: Acromegaly News



MedWorm.com provides a medical RSS filtering service. Thousands of medical RSS feeds are combined and output via different filters. This feed contains the latest news in Acromegaly



Last Build Date: Mon, 19 Feb 2018 06:26:31 +0100

 



FDA Grants Orphan Drug Designation to Dauntless Pharmaceuticals' DP1038 for the Treatment of Acromegaly

Tue, 30 Jan 2018 15:51:29 +0100

SAN DIEGO, Jan. 30, 2018 -- (Healthcare Sales & Marketing Network) -- Dauntless Pharmaceuticals, Inc., a privately held biopharmaceutical company focused on the development of specialty therapeutics announces that the U.S. Food and Drug Administration (FD... Biopharmaceuticals, FDA Dauntless Pharmaceuticals, acromegaly (Source: HSMN NewsFeed)

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Premenopausal women have poorer outcomes after adenomectomy

Mon, 08 Jan 2018 12:00:00 +0100

According to a study, published in theJournal of Clinical Endocrinology& Metabolism, premenopausal women with acromegaly have worse outcomes after transsphenoidal adenomectomy.Healio (Source: Society for Endocrinology)



Acromegaly patients in remission still at increased risk of diabetes

Tue, 05 Dec 2017 12:00:00 +0100

According to a French study, published in theJournal of the Endocrine Society,even acromegaly patients in remission have an increased risk of developing diabetes and related metabolic disorders.Healio (Source: Society for Endocrinology)



EndoBreak: T1D and Vitamin D; VA's T2D Guideline; Oral Acromegaly Drug

Fri, 27 Oct 2017 17:30:00 +0100

(MedPage Today) -- News and commentary from the endocrinology world (Source: MedPage Today Cardiovascular)



World ’s tallest 12-year-old towers above at 7ft 5ins

Tue, 17 Oct 2017 08:17:31 +0100

Gabriel Gomes, from Brazil, suffers from gigantism, caused by a tumour of the pituitary gland. A documentary called Body Bizarre, airing on Thursday, follows the boy's journey. (Source: the Mail online | Health)



Chiasma begins enrolment in Phase III trial for acromegaly

Thu, 28 Sep 2017 23:00:00 +0100

Chiasma has started patient enrolment in Phase III CHIASMA OPTIMAL clinical trial of its product candidate Mycapssa (octreotide capsules) as a maintenance therapy to treat adults with acromegaly. (Source: Drug Development Technology)

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Midatech files CTA for MTD201 ’s carcinoid cancer and acromegaly trial

Mon, 04 Sep 2017 23:00:00 +0100

UK-based specialist pharmaceutical firm Midatech Pharma has submitted a clinical trial application (CTA) for its drug candidate MTD201 to treat carcinoid cancer and acromegaly. (Source: Drug Development Technology)



Chiasma and FDA agree on new Phase III trial design for acromegaly drug

Sun, 13 Aug 2017 23:00:00 +0100

The US Food and Drug Administration (FDA) has agreed on biopharmaceutical firm Chiasma ’s new Phase III clinical trial (OPTIMAL) design to evaluate its octreotide capsules product candidate Mycapssa as a maintenance therapy to treat adults with acrome… (Source: Drug Development Technology)



Kent hairdresser with acromegaly could not stop growing

Tue, 18 Jul 2017 14:56:42 +0100

Lauren Bates, 26, from New Romney, Kent, was diagnosed with acromegaly. The rare condition was made famous by Richard Kiel, who played Jaws in The Spy Who Loved Me. (Source: the Mail online | Health)



Kent hairdresser reveals her feet wouldn't stop growing

Tue, 18 Jul 2017 09:12:09 +0100

Lauren Bates, 26, from New Romney, Kent, was diagnosed with acromegaly. The rare condition was made famous by Richard Kiel, who played Jaws in The Spy Who Loved Me. (Source: the Mail online | Health)



Celebrating 10 years of success for Infusion

Tue, 11 Jul 2017 14:39:20 +0100

As the business took off, more space was needed, and the company moved in 2009 to “real” office space just up the road in Haddam, CT, across the street from the Connecticut River, eventually employing a staff of 10 that year. A year later, in 2010, Infusion had doubled in size and became part of the UDG/Ashfield family. Infusion continued to grow at a steady pace into new therapeutic areas with more clients and employees, and in October 2016, Infusion left its country setting and moved into larger corporate offices in downtown Middletown, CT. Our staff now comprises 45 people and includes account executives, medical writers, scientific directors, medical editors, and graphic designers. Three of the four original employees still work at Infusion (Matt, Angela, and Rick Kemmerer), and ma...

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Ipsen wins approval for gastroenteropancreatic neuroendocrine tumor drug

Mon, 03 Jul 2017 17:22:15 +0100

Ipsen (EPA:IPN) said today that Teijin Pharma Ltd. won approval from the Japanese Ministry of Health, Labor and Welfare for Ipsen’s Somatuline as a therapy for gastroenteropancreatic neuroendocrine tumors. The subcutaneous drug was approved in Japan in 2012 for the treatment of acromegaly and pituitary gigantism. Get the full story at our sister site, Drug Delivery Business News. The post Ipsen wins approval for gastroenteropancreatic neuroendocrine tumor drug appeared first on MassDevice. (Source: Mass Device)



Impaired QoL in Patients With Treated Acromegaly Impaired QoL in Patients With Treated Acromegaly

Fri, 30 Jun 2017 05:14:58 +0100

Find out which factors may negatively impact quality of life among patients with treated and controlled acromegaly.Clinical Endocrinology (Source: Medscape Today Headlines)



Karachi father unable to get a job due to his giant hands

Wed, 31 May 2017 14:13:51 +0100

Ashraf-ud-din, 70, from Karachi, has suffered with the rare macrodactyly all of his life - a congenital form of gigantism. It has left him unable to get a job and has stopped him from gaining any skills. (Source: the Mail online | Health)



Radiation Tx for Persistent Acromegaly Safe, Effective

Thu, 04 May 2017 21:37:52 +0100

(MedPage Today) -- Helped normalize IGF-1 levels after surgery failed (Source: MedPage Today Surgery)



Medical management for acromegaly offers hope for patients

Fri, 07 Apr 2017 12:00:00 +0100

In this video, Maria Fleseriu, MD, FACE, professor of medicine and neurological surgery at Oregon Health& Science University in Portland, discusses updates in the management of acromegaly.Healio (Source: Society for Endocrinology)

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Society partner Pfizer introduces 2017 ASPIRE Young Investigator Research Awards in Endocrinology

Mon, 20 Mar 2017 12:00:00 +0100

The mission of the 2017 Global ASPIRE Young Investigator Research Awards in Endocrinology is to advance the medical knowledge of the fundamental mechanisms of disease, mechanisms of action of current and potential future treatments, and to improve the care of patients with endocrine disorders.Pfizer invites junior investigators to apply for the 2017 Global ASPIRE Young Investigator Research Awards in Endocrinology from6 March 2017. Funding will be provided to research proposals that seek to explore translational or clinical research in the area of endocrine disease in children and young adults to address:Morbidity and mortality in Adult Growth Hormone Deficiency or AcromegalyImpact and/or needs of the patient with Growth Disorders during the pediatric and transitional years/young ...



Predictors of Quality of Life in Patients With Acromegaly Predictors of Quality of Life in Patients With Acromegaly

Wed, 15 Mar 2017 04:34:05 +0100

Certain factors may predict the impact of acromegaly on patient quality of life. What are they?Endocrine Practice (Source: Medscape Orthopaedics Headlines)



Pachydermoperiostosis Masquerading as Acromegaly Pachydermoperiostosis Masquerading as Acromegaly

Fri, 10 Mar 2017 07:20:29 +0100

This case of pachydermoperiostosis highlights the differential diagnoses that should also be considered when acromegaly is suspected.Journal of the Endocrine Society (Source: Medscape Today Headlines)



Make the Diagnosis: Unusual Adenoma

Mon, 06 Mar 2017 15:10:11 +0100

(MedPage Today) -- Case Findings: A 42-year-old male presents with a long history of headaches, impaired vision, and fatigue. He mentions that his wedding ring no longer fits, and he reports joint pain. On physical exam, he has swollen hands and feet, coarse facial features, and partial blindness (bitemporal hemianopsia). After diagnosis with acromegaly secondary to a pituitary macroadenoma, the patient is referred for surgery. However, the patient's IGF-1 concentrations remain elevated following a debulking procedure (the tumor location prevented full resection). What is the best next step for this patient? (Source: MedPage Today Cardiovascular)



Acromegaly tied to worsening heart structure and function

Mon, 13 Feb 2017 12:00:00 +0100

Adults with acromegaly are more likely to have subclinical atherosclerosis with structural and functional damage to the heart, according to findings published inEndocrine Practice.Healio (Source: Society for Endocrinology)

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Writer whose jaw expanded because of rare condition reveals how he could die at any minute

Mon, 09 Jan 2017 18:36:59 +0100

Up to 8,300 people in the UK, including Mike Scalise, have acromegaly - where the body produces too much growth hormone - but it often isn't diagnosed until patients are in their 40s. (Source: the Mail online | Health)



Writer, 38, whose jaw expanded in size because of a rare condition made famous by a James Bond villain reveals how he could die at any minute from stress

Mon, 09 Jan 2017 17:11:32 +0100

Up to 8,300 people in the UK, including Mike Scalise, have acromegaly - where the body produces too much growth hormone - but it often isn't diagnosed until patients are in their 40s. (Source: the Mail online | Health)



What are Potential Health Problems Associated with Polycystic Ovary Syndrome?

Mon, 05 Dec 2016 00:36:48 +0100

DiscussionPolycystic ovary syndrome (PCOS) affects 6-8% of reproductive-age women making it the most common endocrinopathy in this age group. There is no consensus on the specific diagnostic criteria for PCOS in adolescents as many of the characteristics overlap with normal adolescent physiology. However, patients should have evidence of hyperandrogenism, oligo- or amenorrhea, and potentially polycystic ovaries. PCOS has a genetic component although a specific gene has not been identified. Incidence of PCOS is 20-40% for a woman with a family history. Hyperandrogenism Androgen levels change during puberty therefore actual measurement and interpretation can make the diagnosis more difficult. Obesity increases androgens. Puberty is associated with a 25-50% decrease in insulin sensitivity. Th...



This Teen Is Almost 8 Feet Tall -- And Still Growing

Thu, 22 Sep 2016 23:53:49 +0100

At 7 feet 8 inches, Broc Brown definitely sticks out in a crowd, and he’s only going to get bigger. Brown’s family knew something was up at a young age: He was 5-foot-2 in kindergarten, according to his mother, Darci Elliot. “When he got into middle school he was around 6 feet tall, and by high school he was 7 feet tall,” Elliot told Barcroft TV. “It’s a genetic disorder and there’s nothing that can stop him from growing – I don’t know if he will ever stop.” Brown, 19, grows an astounding six inches a year because of a rare genetic disorder called Sotos syndrome, or cerebral gigantism. The condition reportedly affects 1 in 14,000 newborns, but the National Institutes of Health says the number may be closer to 1...



What Causes Hyperphosphatemia?

Mon, 12 Sep 2016 00:49:32 +0100

Discussion Constipation is a common problem in general pediatrics and its causes are numerous. It can cause acute and recurrent abdominal pain and is a cause of abdominal distention. Patients who are young, whose presentations are other than routine or who had complications should be invested for underlying causes of their constipation. This patient had undergone some evaluations in the past for constipation but because of the presentation of sepsis a more rigorous evaluation was undertaken. The differential diagnoses of the following can be found here: constipation, acute abdominal pain, recurrent abdominal pain, and abdominal distention. Hyperphosphatemia caused by retention of oral phosphate containing medications and hypertonic sodium phosphate enemas are known causes of hyperphosphat...

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Acromegaly FAQs

Fri, 15 Jul 2016 07:00:00 +0100

(Source: eMedicineHealth.com)



Understanding Acromegaly Medications

Fri, 15 Jul 2016 07:00:00 +0100

Acromegaly Medications (Source: eMedicineHealth.com)



Camurus concludes Phase II trial of CAM2029 to treat NETs

Wed, 13 Jul 2016 23:00:00 +0100

Swedish-based pharmaceutical company Camurus has concluded the Phase II study of CAM2029 to treat acromegaly or neuroendocrine tumours (NETs). (Source: Drug Development Technology)



Indian man with enormous 20kg arm is forced to leave his home

Wed, 25 May 2016 22:41:18 +0100

Bablu, who was forced to flee to Mumbai, suffers from local gigantism, which is the result of an over-productive growth hormone. His condition means he even struggles to hold a cup of water. (Source: the Mail online | Health)



Radiosurgery in Patients With Acromegaly or Cushing DiseaseRadiosurgery in Patients With Acromegaly or Cushing Disease

Tue, 10 May 2016 04:24:35 +0100

A new study reports on the incidence of hypopituitarism after gamma knife radiosurgery in patients with acromegaly or Cushing's disease. Clinical Endocrinology (Source: Medscape Today Headlines)

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FDA rejects Chiasma's drug to treat growth disorder

Thu, 21 Apr 2016 12:00:00 +0100

The U.S. Food and Drug Administration has rejected Chiasma Inc's experimental drug to treat adults with acromegaly, the company said on Friday. Reuters (Source: Society for Endocrinology)



ACROSCORE: A New and Simple Tool for Diagnosing AcromegalyACROSCORE: A New and Simple Tool for Diagnosing Acromegaly

Tue, 19 Apr 2016 16:00:00 +0100

A novel scoring tool has been developed that may play an important role in the diagnosis of this rare disease. Clinical Endocrinology (Source: Medscape Today Headlines)



Your Dentist Is More Important to Your General Health Than You May Realize

Tue, 29 Mar 2016 18:30:51 +0100

Most people view their twice-yearly visits to the dentist as little more than a cleaning and a check-up. But in reality, those visits are much more important than you probably realize. That's because your dentist is looking inside your mouth for a lot more than cavities. Plenty of medical conditions -- including some alarming ones! -- manifest in the mouth, which is the part of your body your dentist knows the most about. In fact, it's possible that your dentist is able to alert you of a potentially serious condition long before you even think about going to a primary care doctor. Here's a list of some of the medical conditions that your dentist may detect. Acromegaly When a pituitary adenoma (cancer) occurs, it causes the gland to secrete excess growth hormone. While this hormone is esse...



Greeks Gone West: The Geneticist Helping To Treat 'Gigantism'

Fri, 16 Oct 2015 20:12:58 +0100

Constantine A. Stratakis - Greeks Gone West by HuffPost_Greece In the third episode of HuffPost Greece's video series 'Greeks Gone West,' we introduce Constantine A. Stratakis, M.D. D.Sc., a tenured investigator in the NICHD, who has been the head of the Section on Genetics and Endocrinology (SEGEN) since its inception in 1999. His work is focused on treating the rare condition of 'gigantism.' The research began with a family who came to the the U.S. National Institutes of Health for treatment for gigantism in the mid-1990s. In that family, the mother and two of her sons all had the condition. This is his story. Watch the first and second episodes of 'Greeks Gone West' here and here. -- This feed and its contents are the property of The Huffington Post, a...

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How Big Could a World Record Pumpkin Get?

Fri, 02 Oct 2015 19:18:15 +0100

This article originally appeared on Inverse. By Ben Guarino Thanks to the efforts of Illinois farmer Gene McMullen, the North American record for the heaviest pumpkin now sits at 2,145 pounds. McMullen's Cucurbita Maxima Brobdingnag is the second greatest pumpkin the world has ever known, trailing only Beni Meier of Switzerland's monster fruit, which tipped the scales at 2,378 pounds in 2014. The most remarkable thing about these overachieving gourds is that their size is not singular: The weight of the massive pumpkin growth has been linear over the past few decades according to an analysis by University of Wisconsin-Madison horticulturalists. So, when does it hit critical mass? How high peak pumpkin can go is unclear. Purdue University botanist Dan Egel flatly refused to speculate on a ...



Indian boy with giant hands from local gigantism gets life changing operation

Mon, 10 Aug 2015 16:50:47 +0100

Mohammad Kaleem, eight, from Jharkhand State, eastern India, was born with a form of giantism which has seen his hands and arms grow until they weighed a colossal two stone between them. (Source: the Mail online | Health)



Why Were Dinosaurs So Big?

Tue, 07 Jul 2015 19:14:02 +0100

Why were dinosaurs so big?: originally appeared on Quora: The best answer to any question. Ask a question, get a great answer. Learn from experts and access insider knowledge. You can follow Quora on Twitter, Facebook, and Google+. Answer by Marc Srour, Invertebrate Paleontologist Image by MathKnight There is actually no uncontroversial explanation for the as-of-yet unparalleled size of dinosaurs. If you look at the distribution of large sizes in dinosaurs, one distinction becomes clear: the only dinos that were small (less than 1m) were carnivorous theropods. Except for the 70 cm Fruitadens Haagarorum, no herbivorous ornithischians were small. The evolution of teeth in ornithischian lineages proceeded along very similar lines independently, and each innovation was accompanied by a bump ...



Research Goal: 'No More Giants'Research Goal: 'No More Giants'

Sat, 25 Apr 2015 12:19:13 +0100

A gene linked to 'gigantism' may hold the key to identifying and treating babies who otherwise would grow extremely tall and have shortened life spans. Medscape Diabetes & Endocrinology (Source: Medscape Diabetes Headlines)



Funding for nurses wishing to attend ECE 2015

Thu, 26 Mar 2015 12:00:00 +0100

An educational programme for endocrine nurses has been arranged at ECE 2015 in Dublin. It includes a half-day pre-congress course on Acromegaly on Saturday 16 May and 3 dedicated nurse sessions as part of the ECE Programme on 17 and 18 May. There will also be opportunities for networking during catering breaks and poster presentations. An unrestricted educational grant which can fund up to 55 nurses with a €500 travel grant to attend the Acromegaly course and ECE meeting has been provided by pharmaceutical sponsors; these will be awarded on a first-come-first-serve basis. Please visit the ECE 2015 website for further details. (Source: Society for Endocrinology)

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Chiasma Announces Completion of $70 Million Series E Financing

Fri, 27 Feb 2015 14:49:58 +0100

NEWTON, Mass. and JERUSALEM, Feb. 27, 2015 -- (Healthcare Sales & Marketing Network) -- Chiasma, Inc., a U.S. privately-held biopharma company developing octreotide capsules, its lead product for the orphan condition acromegaly, today announced the closin... Biopharmaceuticals, Venture CapitalChiasma, octreotide capsules, acromegaly (Source: HSMN NewsFeed)



Acromegaly Responds to Oral Drug in Trial (CME/CE)

Tue, 10 Feb 2015 00:35:00 +0100

(MedPage Today) -- Tradeoff between convenience and lower response rate versus injectable treatments. (Source: MedPage Today Endocrinology)



New Indications for Somatostatin Analogs

Fri, 19 Dec 2014 13:00:00 +0100

(MedPage Today) -- FDA okayed pasireotide for acromegaly and lanreotide for gastroenteropancreatic neuroendocrine tumors. (Source: MedPage Today Endocrinology)



FDA Okays Pasireotide (Signifor LAR) for AcromegalyFDA Okays Pasireotide (Signifor LAR) for Acromegaly

Wed, 17 Dec 2014 15:11:52 +0100

The long-acting somatostatin analog pasireotide has been approved for the additional indication of treatment of acromegaly in the US, for patients who don't respond well to surgery or first-line agents. FDA Approvals (Source: Medscape Diabetes Headlines)



Novartis receives FDA approval for Signifor LAR to treat acromegaly

Wed, 17 Dec 2014 00:00:00 +0100

Swiss drugmaker Novartis has received approval from US Food and Drug Administration (FDA) for its Signifor long-acting release LAR (pasireotide) for injectable suspension and intramuscular use to treat patients with acromegaly. (Source: Pharmaceutical Technology)

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Gene Discovery in Giants Could Shed Light on Human GrowthGene Discovery in Giants Could Shed Light on Human Growth

Tue, 09 Dec 2014 19:23:23 +0100

A duplication in a gene on the X chromosome is associated with an early-onset form of gigantism; the discovery is likely to shed light on how growth hormone is regulated, the researchers say. Medscape Medical News (Source: Medscape Medical News Headlines)



Genetic basis for gigantism identified

Tue, 09 Dec 2014 12:00:00 +0100

Researchers at the National Institutes of Health have found a duplication of a short stretch of the X chromosome in some people with a rare disorder that causes excessive childhood growth; their study was published this week in The New England Journal of Medicine. Medical Xpress (Source: Society for Endocrinology)



This Week: CDC Says Severe Flu Season Possible

Fri, 05 Dec 2014 22:33:26 +0100

(MedPage Today) -- The CDC warns about the coming flu season, and researchers report on a possible cause of gigantism in children. (Source: MedPage Today Public Health)



Duplication of gene on X chromosome causes gigantism

Thu, 04 Dec 2014 22:32:59 +0100

Brooks HaysBETHESDA, Md., Dec. 4 (UPI) -- Researchers now believe gene duplication in a specific chromosome region, key in growth regulation, is responsible for the rare disorder known as gigantism. (Source: Health News - UPI.com)



Duplication Error May Make Giants

Thu, 04 Dec 2014 17:30:26 +0100

(MedPage Today) -- Novel mutation may underlie some cases of gigantism. (Source: MedPage Today Pediatrics)

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NIH researchers link chromosome region to gigantism

Thu, 04 Dec 2014 13:38:00 +0100

Duplication of gene on X chromosome appears to cause excessive growth (Source: National Institutes of Health (NIH) News Releases)



Scientists May Have Spotted Genetic Cause of 'Gigantism'

Thu, 04 Dec 2014 07:00:00 +0100

Title: Scientists May Have Spotted Genetic Cause of 'Gigantism'Category: Health NewsCreated: 12/3/2014 12:00:00 AMLast Editorial Review: 12/4/2014 12:00:00 AM (Source: MedicineNet Kids Health General)



Novartis received EU approval for drug that treats rare hormonal disorder

Tue, 25 Nov 2014 12:00:00 +0100

Novartis International has announced that it has received approval from the European Commission for its drug called Signifor to treat the rare hormonal disorder acromegaly. HNGN (Source: Society for Endocrinology)



European Commission grants approval for Novartis's Signifor to treat acromegaly

Tue, 25 Nov 2014 03:30:00 +0100

Swiss drug-maker Novartis has received approval from European Commission for its Signifor (pasireotide) intramuscular injection to treat adult patients suffering from acromegaly. (Source: Pharmaceutical Technology)



New guidelines for acromegaly include advice on pregnancy

Tue, 11 Nov 2014 10:36:59 +0100

The European Society of Endocrinology and the Endocrine Society have cosponsored a clinical practice guideline for the diagnosis and treatment of acromegaly. This is now available online in the Journal of Clinical Endocrinology & Metabolism. JCEM (Source: Society for Endocrinology)

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New Guidelines for Acromegaly Include Advice on PregnancyNew Guidelines for Acromegaly Include Advice on Pregnancy

Mon, 10 Nov 2014 15:22:18 +0100

The US Endocrine Society issues first-ever guidance on management of acromegaly, cosponsored by the European Society of Endocrinology. Medscape Medical News (Source: Medscape Medical News Headlines)



Acromegaly diagnosis and treatment guideline issued by The Endocrine Society

Thu, 06 Nov 2014 12:00:00 +0100

A new clinical practice guideline developed by The Endocrine Society and published in the Journal of Clinical Endocrinology & Metabolism addresses evaluation and management of acromegaly. Healio (Source: Society for Endocrinology)



Experts recommend tumour removal as first-line treatment for acromegaly

Fri, 31 Oct 2014 12:00:00 +0100

The Endocrine Society has today issued a Clinical Practice Guideline for the diagnosis and treatment of acromegaly, recommending that surgery to remove tumours from the pituitary gland should be the primary treatment for most patients. EurekAlert (Source: Society for Endocrinology)



Experts recommend tumor removal as first-line treatment for acromegaly

Thu, 30 Oct 2014 04:00:00 +0100

(The Endocrine Society) The Endocrine Society today issued a Clinical Practice Guideline for the diagnosis and treatment of acromegaly, a rare condition caused by excess growth hormone in the blood. (Source: EurekAlert! - Medicine and Health)



Teenager Keiran Halliday grows 8 inches in a YEAR after brain tumour

Wed, 15 Oct 2014 15:32:20 +0100

Keiran Halliday, 19, from Bridgend, South Wales, has shot up eight inches in the last year after he was diagnosed with acromegaly, where the body produces too much growth hormone. (Source: the Mail online | Health)

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Ghrelin paralleled adiposity increase after acromegaly surgery

Mon, 15 Sep 2014 09:02:29 +0100

The rise in total ghrelin found to accompany some remaining cardiovascular risk markers and adiposity increase in patients with acromegaly remission after surgery could be interrelated, according to research published in The Journal of Clinical Endocrinology & Metabolism.  Healio (Source: Society for Endocrinology)



Understanding Acromegaly Medications

Mon, 15 Sep 2014 07:00:00 +0100

Acromegaly Medications (Source: eMedicineHealth.com)



Acromegaly FAQs

Thu, 28 Aug 2014 07:00:00 +0100

(Source: eMedicineHealth.com)



Hustle and bustle at ICE/ENDO 2014

Wed, 02 Jul 2014 12:00:00 +0100

I arrived at McCormick Place to find all the usual hustle and bustle associated with ENDO. I queued, picked up my chic (!) backpack and rushed off to hang my poster. I also had a chance to take a peak at the history of endocrinology timeline as the Endocrine Society approaches it's centenary.  ENDO2014 was officially kicked off yesterday by Robert Lefkowitz who gave us an insightful tour through his lifetime's research on seven transmembrane receptors. His more recent discoveries on B-arrestins were fascinating. I bumped into Sam Mirczuk, Chair of the YE committee in this session :) John Newell-Price displayed the quality of clinical Endocrinology in the UK during the 'Acromegaly: An Endocrine Society Clinical Practice Guideline' session, with an ...



'I'm the real life Jaws': Student, 36, has condition which means his jaw bone won't stop growing

Fri, 20 Jun 2014 18:45:50 +0100

Richard Moore, from Wigan, has acromegaly - meaning some of his bones continue to increase in size after the skeleton and other organs have finished growing. (Source: the Mail online | Health)

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2014 ASPIRE Young Investigator Research Awards in Endocrinology

Wed, 21 May 2014 12:00:00 +0100

The mission of the 2014 ASPIRE Young Investigator Research Awards in Endocrinology is to advance the medical knowledge of the fundamental mechanisms of disease, mechanisms of action of current and potential future treatments, and to improve the care of patients with endocrine disorders. Funding will be provided to research proposals that seek to explore basic, translational, or clinical research in the area of endocrine disease in adults and children: Clinical and Translational Research in the GH and IGF-I Axis Morbidity and Mortality in Patients with Acromegaly Novel measures of growth hormone treatment benefits Supported by Pfizer, there are two awards available of US$50,000 for one year. For more information about the award and details of how to apply please see the link below....



Pasireotide LAR for Acromegaly but Hyperglycemia a DrawbackPasireotide LAR for Acromegaly but Hyperglycemia a Drawback

Thu, 15 May 2014 22:26:23 +0100

Pasireotide LAR improves response in acromegaly patients poorly controlled on first-generation somatostatins, but hyperglycemia remains an issue as the agent awaits regulatory approval for this indication. Medscape Medical News (Source: Medscape Diabetes Headlines)



New Funding for Clinical Endocrinology Quality Improvement Projects available from the Clinical Endocrinology Trust

Fri, 25 Apr 2014 12:00:00 +0100

The Clinical Endocrinology Trust has long supported Endocrine Audit projects within the UK.  Recent examples include the UK Acromegaly Database, the CaHASE audit of adults with CAH, and a BTA study of teenage iodine status across the UK. The Trustees now invite further applications from Societies or Endocrine Centres within the UK.  Preference will be given to projects involving multicentre collaborations.  We are particularly interested in receiving applications related to areas of endocrinology the Trust has not supported previously.  A total sum of £50,000 is available during 2014-2015 for a number of projects judged by the Trustees to be worthy of support. Their decision will be final.  The trustees require that projects ...



Acromegaly, IGF1 bioactivity, and S-Klotho

Fri, 25 Apr 2014 12:00:00 +0100

The value of measuring IGF1 bioactivity in active acromegaly is unknown. Soluble Klotho (S-Klotho) level is elevated in active acromegaly and it has been suggested that S-Klotho can inhibit activation of the IGF1 receptor (IGF1R). A cross-sectional study was carried out in 15 patients with active acromegaly, finding that IGF1 bioactivity was within the reference range in a considerable number of subjects with active acromegaly and that elevated S-Klotho levels may have reduced IGF1 bioactivity. Moreover, IGF1 bioactivity was more strongly related to physical measures of QoL than total IGF1, suggesting that IGF1 bioactivity may better reflect physical limitations perceived in active acromegaly. Read the full article at Varewijck et al. (2014) Endocrine Connections 3 85–92 http://...



Sharing your patient record can help researchers save and improve lives

Tue, 14 Jan 2014 12:00:00 +0100

The Society for Endocrinology is supporting a new campaign to raise awareness about the importance of sharing data from patient records with researchers. By allowing researchers access to the information contained within our records, we can contribute towards understanding the causes of disease and develop new and better medicines. Access to health data has played a major role in the Society's own project, such as the UK Acromegaly Register. This project, initially set up in 1997, collects prospective and retrospective data on patients with acromegaly to assess outcomes of surgery, radiotherapy and medical therapy. The data is disseminated in peer-reviewed journals, at conferences and fed back to patient support groups. The campaign, run by NHS England, is supported by m...

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New research on sauropod gigantism summarized in publicly available collection

Tue, 14 Jan 2014 05:00:00 +0100

(Johannes Gutenberg Universitaet Mainz) Dr. Eva Maria Griebeler of Johannes Gutenberg University Mainz has now shown that the hypothesis is inaccurate that their body size was limited only because the associated rise in body temperature could have resulted in potential overheating. (Source: EurekAlert! - Biology)



Growth Disorder Tx Has Room for Improvement (CME/CE)

Fri, 11 Oct 2013 20:26:43 +0100

(MedPage Today) -- Although control of the disease has improved over the past few decades, about a quarter of patients with acromegaly aren't hitting treatment targets, British researchers found. (Source: MedPage Today Pediatrics)



UK Acromegaly Register: drugs fail to meet hormone targets in control of rare growth disorder

Thu, 10 Oct 2013 12:00:00 +0100

A study by the Society for Endocrinology UK Acromegaly Register published in Clinical Endocrinology assesses medical treatment of acromegaly in routine clinical practice over 30 years. Full article Clinical Endocrinology is the Society for Endocrinology's official clinical journal. (Source: Society for Endocrinology)



A bigger fish for palaeontogists to fry…

Sat, 24 Aug 2013 23:06:21 +0100

A chance find in a quarry led to the discovery that Leedsichthys problematicus grew up to 50ft long – double previous estimatesAn international team of scientists has uncovered the remains of the world's largest fish. The 50ft Leedsichthys problematicus swam the oceans of the Jurassic era more than 160m years ago, sweeping up shoals of plankton through giant, mesh-covered gills. Leedsichthys was eventually wiped out by the same catastrophe that killed the dinosaurs 66m years ago.The discovery by the team – led by Professor Jeff Liston of the National Museums of Scotland – is intriguing because it reveals that just as dinosaurs on land were going through major changes which saw the appearance of animals of vast dimensions – creatures that included Diplodocus, Apatosaurus and Brachio...



Discuss quality of life with acromegaly patients

Wed, 24 Jul 2013 00:00:00 +0100

Read the full story on MD Consult: Discuss quality of life with acromegaly patients (Source: MD Consult: News: Top Stories)

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What Causes Hypercalcemia?

Mon, 25 Mar 2013 00:57:01 +0100

Discussion Calcium homeostasis is regulated by mechanisms involving the absorption from the gastrointestinal tract, bone deposition and resorption, and renal excretion. To review Vitamin D homeostasis click here. Serum calcium is found in three forms: free (47%), protein bound (43%) and diffusable calcium complexes (10%). The protein binding proteins are albumin (80%) and globulin (20%). The free calcium is the most important biologically. Acidosis also increases free calcium and alkalosis decreases free calcium. Problems associated with hypercalcemia include nausea, emesis, abdominal pain, constipation, polyuria, dehydration, mental status changes and coma. Learning Point The differential diagnosis of hypercalcemia includes: Hyperparathyroidism Primary Familial isolated Familial hyperc...



Roche and Chiasma announce collaboration to develop and commercialize Chiasma's Octreolin for acromegaly and neuroendocrine tumors

Tue, 19 Feb 2013 14:45:17 +0100

Basel, 18 February 2013-Roche (SIX: RO, ROG; OTCQX: RHHBY) and Chiasma (pronounced key-azma) Inc., a privately held biopharma company, announced today that they have entered into an agreement to develop and commercialize Chiasma’s proprietary... (Source: Drugs.com - Pharma News)



Roche, Chiasma ink deal on hormone disorder treatment (Reuters, 18 February 2013)

Tue, 19 Feb 2013 12:00:00 +0100

Drugmakers Roche and Chiasma have announced plans to work together to develop and market an oral formulation of octreotide for patients with acromegaly. Full article (Source: Society for Endocrinology)



Roche, Chiasma partner to develop, commercialise Octreolin

Tue, 19 Feb 2013 00:00:00 +0100

Roche and Chiasma have partnered to develop and commercialise Octreolin, an investigational oral regimen for acromegaly and neuroendocrine tumours. (Source: Drug Development Technology)



Roche and Chiasma announce collaboration to develop and commercialize Chiasma's Octreolin(R) for acromegaly and neuroendocrine tumors

Mon, 18 Feb 2013 12:59:21 +0100

BASEL, Switzerland, NEW YORK and JERUSALEM, Feb. 18, 2013 -- (Healthcare Sales & Marketing Network) -- Roche (SIX: RO, ROG; OTCQX: RHHBY) and Chiasma (pronounced key-az-ma) Inc., a privately held biopharma company, announced today that they have entered i... Biopharmaceuticals, Endocrinology, LicensingChiasma, Roche Group, Octreolin, acromegaly (Source: HSMN NewsFeed)

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Roche and Chiasma announce collaboration to develop and commercialize Chiasma's Octreolin for acromegaly and neuroendocrine tumors

Mon, 18 Feb 2013 06:00:00 +0100

Roche and Chiasma (pronounced key-azma) Inc., a privately held biopharma company, announced today that they have entered into an agreement to develop and commercialize Chiasma’s proprietary product Octreolin, initially for acromegaly and subsequently for neuroendocrine tumors. Octreolin is an investigational oral form of the peptide octreotide, a somatostatin analog that is commercially available only by injection. Octreolin is currently in a pivotal phase 3 clinical trial for acromegaly. Under the terms of the agreement, Roche received a worldwide exclusive license to Octreolin, and will assume responsibility for the commercialization of Octreolin. Genentech will market the product in the United States after US FDA approval. (Source: Roche Investor Update)



UK Acromegaly Register Annual General Meeting

Mon, 11 Feb 2013 12:00:00 +0100

We would like to invite you to the UK Acromegaly Register AGM that will take place during the SfE BES 2013 conference. The AGM will take place in Queens Suite A, Harrogate International Centre, 12:00noon-13:00 on Tuesday 19 March 2013, and will be followed by an Ipsen sponsored symposium on acromegaly from 13:00-14:00. (Source: Society for Endocrinology)



Former model with rare growth disease dies

Thu, 17 Jan 2013 19:14:31 +0100

Acromegaly is a disorder in which there is too much growth hormone in the body (Source: Health News: CBSNews.com)



Teijin Pharma to Launch Ipsen?s Somatuline Subcutaneous Injection in the Treatment of Acromegaly and Pituitary Gigantism in Japan

Thu, 17 Jan 2013 13:18:23 +0100

Tokyo, Japan / Paris, France, January 17, 2013 --- Teijin Pharma Limited, the core company of the Teijin Group’s healthcare business, and Ipsen (Euronext: IPN; ADR: IPSEY), today announced the launch of Somatuline® 60/90/120 mg for... (Source: Drugs.com - Pharma News)



Tanya Angus, woman who couldn't stop growing, dies at 34

Wed, 16 Jan 2013 13:31:25 +0100

Tanya Argus became an advocate for acromegaly, a disorder that causes too much growth hormone in body (Source: Health News: CBSNews.com)

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