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Tue, 29 Mar 2016 09:23:37 +0100Background: Chickenpox vaccination in Singapore is not mandatory. At the National University Hospital (NUH), nosocomial transmission has led to a sentinel event and secondary cases. To prevent future transmissions, we studied the impact of Institutional Chickenpox Prevention Program at NUH. (Source: International Journal of Infectious Diseases)
Tue, 22 Mar 2016 13:30:07 +0100Follow me at @drClaire When I talk to parents who are hesitant about vaccines, what they most want to talk to me about are possible side effects of the vaccine. They worry about everything from fevers and soreness to additives to possible links to autism. They rarely worry about the diseases that vaccines prevent—and that’s what worries me most of all. It is the inconvenient truth of vaccine refusal: when you don’t get vaccinated against an illness, you are more likely to catch it. A study just released in the Journal of the American Medical Association (JAMA) makes this very clear. Researchers looked at information about recent measles and pertussis outbreaks. They found that unvaccinated people made up the majority of those who caught measles and a large proportion of those who cau...
Mon, 21 Mar 2016 18:36:04 +0100Vaccine helps prevent shingles in older adults for up to three years The varicella zoster virus causes chickenpox and can remain dormant inside nerve cells. After many years, it can reactivate and travel through the nerve to the skin, causing itching, numbness, tingling or local pain, and then blisters along the nerve path. These blisters are often accompanied with inflammation of the nerves and severe pain, which can affect quality of life. This is called herpes zoster or shingles. It affects people with low immunity such as older people. There are about 5.22 episodes of shingles for every 1000 older people. This is increasing, in part because people are living longer.A team of Cochrane authors based in Brazil worked with the Cochrane Acute Respiratory Infections Group to investigate...
Mon, 14 Mar 2016 14:20:45 +0100Adding second shot at ages 4 to 6 is almost 100 percent effective (Source: WebMD Health)
Mon, 14 Mar 2016 13:00:00 +0100Adding second shot at ages 4 to 6 is almost 100 percent effectiveSource: HealthDay Related MedlinePlus Pages: Chickenpox, Childhood Immunization (Source: MedlinePlus Health News)
Fri, 04 Mar 2016 10:33:00 +0100DOCTORS are trialling a new vaccine to protect children against chickenpox. But where can you buy it and how much is it? (Source: Daily Express - Health)
Fri, 04 Mar 2016 02:21:04 +0100The Varilrix vaccine, which has been available in the UK since 2013 but only given to those vulnerable to complications, will be given to all children between 12 and 23 months in some hospitals (file photo) (Source: the Mail online | Health)
Thu, 03 Mar 2016 00:00:00 +0100CONCLUSIONS: Herpes zoster vaccine is effective in preventing herpes zoster disease and this protection can last three years. In general, zoster vaccine is well tolerated; it produces few systemic adverse events and injection site adverse events of mild to moderate intensity.There are studies of a new vaccine (with a VZV glycoproteic fraction plus adjuvant), which is currently not yet available for clinical use. PMID: 26937872 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Sat, 27 Feb 2016 00:00:00 +0100This study reports the results of a 2012 Lexington-Fayette County, Kentucky, community health assessment's results asking about eight adult vaccinations among 218 lesbian, gay, bisexual, and transgendered (LGBT) respondents. Researchers collected data using an online survey distributed through LGBT social media, posters, and LGBT print media. The LGBT sample largely matches the demographics of the county as a whole except this group reports higher level of education and fewer uninsured individuals. Among LGBT respondents, immunization prevalence reaches 68.0% (annual Influenza), 65.7% (Hepatitis B), 58.8% (Chickenpox/Varicella), 55.9% (Hepatitis A), 41.2% (Smallpox), and 25.8% (Pneumonia). Among respondents who are currently within the recommended 19-26 years age range for the Human Papill...
Thu, 18 Feb 2016 14:00:44 +0100If you had chickenpox as a kid, there is a good chance you may develop shingles later in life. “In fact, one in three is predicted to get shingles during their lifetime,” says Dr. Anne Louise Oaklander, director of the Nerve Unit at Harvard-affiliated Massachusetts General Hospital. The same varicella-zoster virus that causes chickenpox also causes shingles. After the telltale spots of chickenpox vanish, the virus lies dormant in your nerve cells near the spinal cord and brain. When your immunity weakens from normal aging or from illnesses or medications, the virus can re-emerge. It then travels along a nerve to trigger a rash in the skin connected to that nerve. The rash often appears on only one side of your body. The most common locations are the chest, back, or stomach, or above on...
Wed, 10 Feb 2016 00:00:00 +0100Chickenpox is caused by varicella zoster virus (VZV/HHV-3), which is one of the eight human herpes viruses. Although chickenpox has a good prognosis, neurologic complications including encephalitis, acute cerebellar ataxia, myelitis and meningitis may seldom be associated with the disease. Peripheral facial palsy (PFP) is an extremely rare complication in patients with chickenpox. Herein, we report a 12-year-old boy with chickenpox and unilateral peripheral facial palsy, who was successfully treated with short-term steroids and physical rehabilitation. (Source: International Journal of Pediatric Otorhinolaryngology Extra)
Fri, 05 Feb 2016 11:00:20 +0100Called ‘ViroCap,’ this new diagnostic technology is able to discover more viruses in patient samples, as compared to PCR genome sequencing tests It could be the ultimate multi-analysis medical laboratory test ever. Researchers at Washington University School of Medicine in St. Louis have developed a diagnostic test that they claim tests for any virus infecting […] (Source: Dark Daily)
Fri, 05 Feb 2016 07:00:00 +0100Title: Health Tip: Chickenpox Can Be DangerousCategory: Health NewsCreated: 2/5/2016 12:00:00 AMLast Editorial Review: 2/5/2016 12:00:00 AM (Source: MedicineNet Kids Health General)
Mon, 01 Feb 2016 00:00:00 +0100Abstract Varicella zoster virus (VZV) is a neurotropic α‐herpesvirus that causes chickenpox and establishes life‐long latency in the cranial nerve and dorsal root ganglia of the host. To date, VZV is the only virus consistently reported to have an inverse association with glioma. The Glioma International Case‐Control Study (GICC) is a large, multisite consortium with data on 4533 cases and 4171 controls collected across five countries. Here, we utilized the GICC data to confirm the previously reported associations between history of chickenpox and glioma risk in one of the largest studies to date on this topic. Using two‐stage random‐effects restricted maximum likelihood modeling, we found that a positive history of chickenpox was associated with a 21% lower glioma risk, adjusti...
Tue, 26 Jan 2016 07:00:00 +0100Title: Chickenpox, Shingles Vaccines Linked to Rare Eye InflammationCategory: Health NewsCreated: 1/25/2016 12:00:00 AMLast Editorial Review: 1/26/2016 12:00:00 AM (Source: MedicineNet Eyesight General)
Mon, 25 Jan 2016 18:16:34 +0100But study doesn't prove cause-and-effect (Source: WebMD Health)
Wed, 20 Jan 2016 19:29:59 +0100In use for more than 20 years, the varicella zoster virus vaccine for chickenpox and shingles is considered an essential medicine by the World Health Organization (WHO). However, researchers have found, in rare instances, a link between the vaccine and corneal inflammation. It is a finding the researchers say should be discussed by primary care physicians and patients with a history of eye inflammation before getting vaccinated. (Source: ScienceDaily Headlines)
Thu, 07 Jan 2016 00:00:00 +0100Varicella (chickenpox) is a highly infectious, usually self-limited disease caused by the varicella-zoster virus (VZV). In the past the complication-rate of chickenpox in children with a malignancy was approximately 30% [1–3]. With antiviral therapy the outcome improved, the overall mortality currently is 0.05–1% [4–7]. 25% of pediatric oncology patients encounter chickenpox during treatment and 16-20% of these patients will experience morbidity due to complications of this infection [4,8]. Approval of live-attenuated varicella vaccine in the USA was in 1995 for routine use in healthy persons older than one year of age who are susceptible to VZV. (Source: Journal of Clinical Virology)
Wed, 06 Jan 2016 00:00:00 +0100Conclusions: Most of the information assessed in this study was considered by qualified medical doctors and nonmedically qualified respondents to be of reasonably good quality. Although a small amount of information was assessed as poor, not all respondents agreed that the original questioner would have been led to act inappropriately based on the information presented. This suggests that discussion forum websites may be a useful platform through which people can ask health-related questions and receive answers of acceptable quality. (Source: Journal of Medical Internet Research)
Tue, 05 Jan 2016 00:00:00 +0100(Source: Lung)
Wed, 30 Dec 2015 11:03:06 +0100The VirScan test gives doctors insight into a patient’s lifetime exposure to viruses and thus may be developed into a useful medical laboratory test Scientists and pathologists are learning that blood is like a time capsule, holding precious information about exposure to viruses over the years—chickenpox at five, mononucleosis at 18, flu at 40. You […] (Source: Dark Daily)
Fri, 25 Dec 2015 03:52:04 +0100Conclusions. Atypical HFMD has seasonal prevalence. The manifestations of neurologic involvement in atypical HFMD are mild and usually have a good prognosis. CV-A6 is a major pathogen causing atypical HFMD, but not a major pathogen in Chongqing, China. PMID: 26693489 [PubMed - in process] (Source: Biomed Res)
Tue, 15 Dec 2015 17:00:00 +0100The herpes zoster virus causes chickenpox and shingles; following shingles, there appears to be a higher risk of acute cardiovascular events such as stroke or myocardial infarction (Source: Health News from Medical News Today)
Mon, 14 Dec 2015 00:00:00 +0100Primary varicella infection (chickenpox) is common in the UK with over three-quarters of parents reporting a history of chickenpox in their children by 5 years of age.1 Following primary infection, the varicella zoster virus (VZV) remains dormant in the dorsal root ganglia and reactivates in later life following a decline in cell-mediated immunity to cause herpes zoster or shingles (HZ). Although chickenpox is generally mild and self-limiting in healthy children, secondary bacterial infections, pneumonia and neurological complications can occur. The risk of severe chickenpox is higher in immunocompromised individuals, pregnant women and neonates, although most hospitalisations for severe complications are in previously healthy children.2 Shingles is a potentially debilitating conditio...
Sat, 12 Dec 2015 20:00:22 +0100CONCLUSION: We have shown that varicella-zoster virus infection of the appendix is associated with acute appendicitis and possibly also with severity of the disease. PMID: 23297526 [PubMed - indexed for MEDLINE] (Source: Acta Medica: Hradec Kralove)
Sat, 12 Dec 2015 04:15:31 +0100CONCLUSION: Serologic screening for VZV in pregnant women seems crucial. We suggest considering the pregnant women as the target group for future immunization programs in Iran. PMID: 25954490 [PubMed] (Source: Iranian Journal of Microbiology)
Fri, 11 Dec 2015 13:40:38 +0100Varicella (chickenpox) caused by varicella zoster virus (VZV) is an acute and extremely contagious disease.1 According to a WHO position paper,2 global annual disease burden of varicella is estimated to be 140 million cases, 4·2 million severe complications, and 4200 deaths. In developed countries, incidence of chickenpox is 16 cases per 1000 people annually. Of these cases, 3% have complications and 5% need to be admitted to hospital, with a case fatality rate of three per 100 000 cases annually. (Source: LANCET)
Thu, 10 Dec 2015 11:03:34 +0100At least 25 per cent of pupils have been hit by the illness in the past fortnight (Source: Telegraph Health)
Wed, 09 Dec 2015 00:00:00 +0100Sarit Sharma, Shruti Sharma, Deepinder Chhina, RS ChhinaIndian Journal of Critical Care Medicine 2015 19(12):723-725Varicella-zoster virus (VZV) causes 2 clinically and epidemiologically distinct forms of diseases. Chickenpox (varicella) is the disease that results from primary infection with the VZV. Herpes zoster (HZ) results from the reactivation of VZV latently infecting the dorsal root ganglia. We are reporting an outbreak of varicella infection among the health care workers (HCWs) in the Intensive Care Unit (ICU) of a tertiary care hospital. We found transmission of varicella among eight HCWs of pulmonary ICU. They had a history of contact with a patient having HZ infection. Investigation of the outbreak was conducted as per guidelines. Better dissemination of information on disease ...
Tue, 10 Nov 2015 12:26:46 +0100
Fri, 06 Nov 2015 00:00:00 +0100We report the case of a 7-year-old boy with a papulovesicular eruption lasting for 4weeks, secondarily associated with ulcers and necrotic crusts, fever, and systemic signs. After exploring infectious causes such as chickenpox, we discussed and confirmed PLEVA with histological analysis. Systemic steroids and methotrexate improved the symptoms. It is necessary to mention PLEVA in case of prolonged papulovesicular eruption. Prompt diagnosis allows appropriate treatment, although there is no consensus on therapeutic guidelines. PMID: 26552626 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Fri, 16 Oct 2015 00:00:00 +0100Conclusion: The introduction of varicella vaccine in the universal immunisation programme of India may help to prevent these outbreaks; however, the cost-benefit analysis needs to be carried out before making such policies. (Source: Indian Journal of Medical Microbiology)
Sat, 10 Oct 2015 00:00:00 +0100(Source: MayoClinic.com - Ask a Specialist)
Sun, 04 Oct 2015 00:00:00 +0100ConclusionsThese findings suggest that lower rates of chickenpox infection secondary to widespread vaccination against varicella zoster virus are not contributing to higher rates of childhood eczema in the U.S. (Source: British Journal of Dermatology)
Fri, 02 Oct 2015 00:00:00 +0100While herpes zoster infection has been recognized since antiquity, chickenpox (varicella) was confused with smallpox until the 1800s, when both illnesses became better understood. In the 20th century, varicella zoster virus (VZV) was shown to cause varicella upon primary (first-time) infection and herpes zoster (shingles) after reactivation of latent VZV. Scientific progress over the past 50 years has rapidly advanced the understanding and prevention of disease produced by VZV. Combined imaging and virological studies continue to reveal the protean neurological, ocular and visceral disorders produced by VZV. (Source: Journal of the Neurological Sciences)
Thu, 01 Oct 2015 00:00:00 +0100We describe the case of an eight-year-old boy with X-linked agammaglobulinemia who developed mild varicella despite regular intravenous immunoglobulin (IVIG) therapy. He maintained protective antibody levels against varicella and the previous batches of IVIG that he received had adequate varicella-specific IgG levels. The case illustrates that IVIG may not prevent VZV infection. PMID: 26603238 [PubMed - in process] (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Sun, 13 Sep 2015 00:00:00 +0100Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): Randall. J. Cohrs, J. Rovnak Varicella zoster virus (VZV) is a ubiquitous neurotropic alphaherpesvirus that typically causes childhood varicella (chickenpox) on primary infection and zoster (shingles) after reactivation. During latency most of the ~70 virus genes are transcriptionally silent; however, analysis of latent VZV gene transcription in its natural setting requires analysis of human ganglia removed at autopsy. Recognizing the problems associated with such samples, we have observed that as the post-mortem time interval increases, so do the number of VZV genes transcribed. Based on our data and recent similar findings concerning reactivation of HSV-1, we propose an ...
Sun, 13 Sep 2015 00:00:00 +0100Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): A Miller, V Traina-Dorge, A Blackmon, M Wellish, E Deharo, D Gilden, R Mahalingam Varicella zoster virus (VZV) causes varicella (chickenpox), establishes latency in ganglia and reactivates decades later to produce zoster in the elderly. Clinical, pathological, immunological and virological features of simian varicella virus (SVV) infection of primates parallel human VZV infection. Primary SVV infection of primates, cause varicella, after which virus becomes latent in ganglionic neurons and reactivates upon social and environmental stress. Five rhesus macaques were infected intrabronchially with 4.0x105 pfu of SVV. Two weeks later, the monkeys developed varicella rash....
Wed, 02 Sep 2015 13:47:28 +0100KANSAS CITY, Mo. -- First the good news for the Kansas City Royals: Alex Gordon came off the disabled list and started in left field, and outfielder Jonny Gomes joined the club Tuesday after being acquired in a trade with the Atlanta Braves... (Source: WDSU.com - Health)
Tue, 01 Sep 2015 05:00:00 +0100This study investigates parental attitudes and factors associated with varicella vaccination among preschool and schoolchildren prior to introduction of the vaccine into Hong Kong's universal Childhood Immunization Program. Fourteen kindergartens and 5 primary schools in Hong Kong were randomly selected in 2013. Parents of the students were invited to answer the self-administered questionnaires. Acquired information included demographic characteristics and socioeconomic statuses of families, children's history of chickenpox infection and vaccination, and reasons for getting children vaccinated. Logistic regression was applied to examine the factors associated with vaccination. From the 3484 completed questionnaires, the calculated rates of varicella infection and vaccination were 20.7% and...
Tue, 01 Sep 2015 00:00:00 +0100Authors: Drighil A, Hammiri AE, Belmourida F PMID: 26431235 [PubMed - in process] (Source: Pediatric Annals)
Mon, 17 Aug 2015 10:21:23 +0100International Journal of Neuroscience, Ahead of Print. (Source: International Journal of Neuroscience)
Fri, 14 Aug 2015 10:13:26 +0100Varicella has continued to decline in the United States as vaccination coverage with the two-dose program has increased, in part because of herd immunity protecting those who were not vaccinated. Medscape Medical News (Source: Medscape Medical News Headlines)
Thu, 13 Aug 2015 14:15:16 +0100Recommendation for second dose reduced number of infections even more, CDC finds (Source: WebMD Health)
Thu, 13 Aug 2015 14:00:00 +0100A new study has revealed cases of chickenpox have been drastically reduced since the introduction of the Varicella vaccine in 1995. (Source: Health News from Medical News Today)
Thu, 13 Aug 2015 13:00:00 +0100Recommendation for second dose reduced number of infections even more, CDC finds Source: HealthDay Related MedlinePlus Pages: Chickenpox, Childhood Immunization (Source: MedlinePlus Health News)
Thu, 13 Aug 2015 04:00:00 +0100(Pediatric Infectious Diseases Society) According to national health care claims data from 1994-2012, CDC researchers Jessica Leung, M.P.H., and Rafael Harpaz, M.D., M.P.H. found that there were 93 percent fewer hospitalizations for chickenpox in 2012 compared to before the vaccine was introduced. During the two-dose varicella vaccination period (2006-2012), hospitalizations declined 38 percent. Outpatient visits also dropped significantly. There were 84 percent fewer outpatient visits in 2012 versus the pre-vaccination period. During the two-dose varicella vaccination period (2006-2012), outpatient visits declined 60 percent. (Source: EurekAlert! - Infectious and Emerging Diseases)
Tue, 11 Aug 2015 18:09:04 +0100BOSTON (AP) -- The furor on Capitol Hill over Planned Parenthood has stoked a debate about the use of tissue from aborted fetuses in medical research, but U.S. scientists have been using such cells for decades to develop vaccines and seek treatments for a host of ailments, from vision loss to cancer and AIDS. Anti-abortion activists triggered the uproar by releasing undercover videos of Planned Parenthood officials that raised questions of whether the organization was profiting from the sale of fetal tissue. Planned Parenthood has denied making any profit and said it charges fees solely to cover its costs. University laboratories that buy such cells strongly defend their research, saying tissue that would otherwise be thrown out has played a vital role in lifesaving medical advances and ho...
Tue, 11 Aug 2015 14:35:55 +0100Re-exposure to chickenpox virus boosts immunity to shingles for a tenth of the time previously thought. So although vaccination increases shingles cases in 31-40 year olds, in the longer term the benefits outweigh the risks, scientists conclude. (Source: ScienceDaily Headlines)
Tue, 11 Aug 2015 10:48:14 +0100BOSTON (AP) — The furor on Capitol Hill over Planned Parenthood has stoked a debate about the use of tissue from aborted fetuses in medical research, but U.S. scientists have been using such cells for decades to develop vaccines and seek treatments for a host of ailments, from vision loss and neurological disorders to cancer and AIDS. Anti-abortion activists set off the uproar by releasing undercover videos of Planned Parenthood officials that raised questions of whether the organization was profiting from the sale of fetal tissue. Planned Parenthood has denied making any profit and said it charges fees solely to cover its costs. University laboratories that buy such cells strongly defend their research, saying tissue that would otherwise be thrown out has played a vital role in lifesavi...
Tue, 11 Aug 2015 04:00:00 +0100(eLife ) Re-exposure to chickenpox virus boosts immunity to shingles for a tenth of the time previously thought. So although vaccination increases shingles cases in 31-40 year olds, in the longer term the benefits outweigh the risks. (Source: EurekAlert! - Infectious and Emerging Diseases)
Tue, 11 Aug 2015 00:00:00 +0100We present the first individual-based model that integrates within-host data on VZV-CMI and between-host transmission data to simulate HZ incidence. This model allows estimating currently unknown pivotal biomedical parameters, including the duration of exogenous boosting at 2 years, with a peak threefold to fourfold increase of VZV-CMI; the VZV weekly reactivation probability at 5% and VZV subclinical reactivation having no effect on VZV-CMI. A 100% effective chickenpox vaccine given to 1 year olds would cause a 1.75 times peak increase in HZ 31 years after implementation. This increase is predicted to occur mainly in younger age groups than is currently assumed. DOI: http://dx.doi.org/10.7554/eLife.07116.001 (Source: eLife)
Sun, 02 Aug 2015 00:00:00 +0100Conclusions: This is the first study of its kind to provide evidence that receiving childhood immunizations may be protective against RMS risk. Although the effect estimates suggested a possible protective role of childhood infections against RMS risk, these findings were not statistically significant. Future studies will be needed to further evaluate the role of immunizations and childhood infections in the development of this tumor.Citation Format: Hari Sankaran, Heather Danysh, Michael E. Scheurer, M. Fatih Okcu, Philip J. Lupo. The role of childhood immunizations and infections on the risk of pediatric rhabdomyosarcoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Canc...
Fri, 31 Jul 2015 21:33:53 +0100Research Articles K. HARIGANE, A. SUMI, K. MISE, N. KOBAYASHI, Epidemiology & Infection, Volume 143 Issue 12, pp 2666-2678Abstract (Source: Epidemiology and Infection)
Sat, 25 Jul 2015 00:00:00 +0100DEAR MAYO CLINIC: I am a healthy 78-year-old man and have never had shingles or the shingles vaccine. I did have chickenpox when I was a child. Is the shingles vaccine something you would recommend for someone like me? What are the side effects of the vaccine? ANSWER: Once you have had chickenpox, the virus [...] (Source: News from Mayo Clinic)
Fri, 24 Jul 2015 00:00:00 +0100In France, the “Sentinelles” network set up by the National Institute for Medical Research has, since the late 1990s, collected and analyzed epidemiological data on chickenpox, also known as varicella . In temperate countries, 90% of cases of varicella-zoster virus (VZV) infection occur before the age of 15 years, with a peak between 1 and 8 years old, and 95% of the population over 30 years old is immunized  . These proportions are lower in tropical areas [3,4]. (Source: Journal of Clinical Virology)
Thu, 23 Jul 2015 00:00:00 +0100ConclusionsThis is the first prospective study to examine a biological measure of exposure to VZV prior to diagnosis of stroke and although we identified no significant association, in this small pilot, with limited characterisation of cases, we cannot exclude the possibility that the virus is causal for a subset. The impact of HIV on risk of stroke has not been well characterised and warrants further study. (Source: Tropical Medicine and International Health)
Wed, 22 Jul 2015 13:03:43 +0100This article reviews the evidence and characteristics of some of the accepted (tuberculosis, measles, chickenpox, whooping cough) and some of the more opportunistic (influenza, Clostridium difficile, norovirus) aerosol-transmitted infectious agents and outlines methods of detecting and quantifying transmission. (Source: Current Treatment Options in Infectious Diseases)
Tue, 21 Jul 2015 05:22:15 +0100Maria Lally's daughter Rosie, 2, from Surrey (pictured in pink) contracted chickenpox and hospitalised after developing an infection. Her sister Sophia, 5, breezed through it. (Source: the Mail online | Health)
Fri, 17 Jul 2015 08:15:54 +0100Herpes zoster, clinically referred to as shingles, is an acute, cutaneous viral infection caused by reactivation of the varicella zoster virus, the same virus that causes chickenpox. The incidence of herpes zoster and its complications increase with decline in cell-mediated immunity, including age-associated decline. The most effective management strategy for herpes zoster is prevention of the disease through vaccination in those who are most vulnerable. Despite the demonstrated efficacy in reducing the incidence and severity of herpes zoster, the uptake of vaccine remains low. Here, we will discuss the controversies that surround the live herpes zoster vaccine and address the common clinical questions that arise. We will also discuss the new adjuvanted herpes zoster vaccine currently unde...
Fri, 17 Jul 2015 00:00:00 +0100We report the case of an immunocompetent patient admitted to the intensive care unit with dyspnea and an exanthematous vesicular rash. We diagnosed varicella pneumonia based on the presence of a typical skin rash, pulmonary symptoms and contact with a child with chickenpox, confirmed by positive serology of varicella zoster virus (VZV). The patient made a full recovery with mechanical ventilation and anti-viral therapy. (Source: Trends in Anaesthesia and Critical Care)
Tue, 14 Jul 2015 00:00:00 +0100CONCLUSIONS: These findings suggest that lower rates of chickenpox infection secondary to widespread vaccination against varicella zoster virus are not contributing to higher rates of childhood eczema in the US. This article is protected by copyright. All rights reserved. PMID: 26179593 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Tue, 14 Jul 2015 00:00:00 +0100ConclusionsThese findings suggest that lower rates of chickenpox infection secondary to widespread vaccination against varicella zoster virus are not contributing to higher rates of childhood eczema in the US.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Wed, 17 Jun 2015 00:00:00 +0100Publication date: August 2015 Source:Journal of Functional Foods, Volume 17 Author(s): Eun-Jin Choi , Chan-Hee Lee , Youn-Chul Kim , Ok Sarah Shin Wogonin is a natural plant-derived flavonoid isolated from the roots of Scutellaria baicalensis. Varicella-zoster virus (VZV) is an α-herpesvirus, which causes chickenpox and shingles. Antiviral activities of natural plant-derived compounds against VZV have not been fully described. Here, we identify the significant inhibitory activity of wogonin against VZV replication. Transcription levels of the VZV genes such as open reading frame 4, 14, and 63 and infectious progeny virus were reduced with wogonin treatment in VZV-infected primary human fibroblast cells. Consistent to our polymerase chain reaction (PCR) array data, our qRT-PCR and ELISA ...
Wed, 17 Jun 2015 00:00:00 +0100ConclusionsThis is the first prospective study to examine a biological measure of exposure to VZV prior to diagnosis of stroke and although we identified no significant association, in this small pilot, with limited characterisation of cases, we cannot exclude the possibility that the virus is causal for a subset. The impact of HIV on risk of stroke has not been well characterised and warrants further study.This article is protected by copyright. All rights reserved. (Source: Tropical Medicine and International Health)
Sat, 13 Jun 2015 10:18:25 +0100CONCLUSION: Prospective studies regarding the interaction between environmental and genetic factors are warranted. PMID: 26062824 [PubMed - as supplied by publisher] (Source: Revista de Neurologia)
Fri, 12 Jun 2015 13:18:26 +0100New results have shown that the chickenpox vaccine can be effective and safe even in children with pediatric rheumatic disease receiving immunosuppression treatment. By using a checklist to pre-screen children, the investigators were able to identify diverse patient groups suitable for vaccination, protecting them from a potentially life-threatening infection. (Source: ScienceDaily Headlines)
Fri, 12 Jun 2015 00:00:00 +0100In conclusion, our data suggest that VZV infection induces SOCS3 expression, resulting in modulation of type I IFN signaling and viral replication. This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Mon, 01 Jun 2015 00:00:00 +0100Authors: Tamir B, Peleg R Abstract A 27-year-old woman in the 21st week of her first pregnancy came to our clinic complaining of a constant burning pain that spread around her left chest wall to her back. She graded the pain as a 10 on a 0 to 10 visual analog scale. The pain, which began 3 months earlier, became worse when she took a deep breath, ate, or walked, but was alleviated by applying warm compresses. Our patient hadn't slept well since the pain began. Her medical history was noteworthy for chickenpox at age 5. PMID: 26172634 [PubMed - as supplied by publisher] (Source: The Journal of Family Practice)
Fri, 29 May 2015 00:00:00 +0100Authors: Vauloup-Fellous C, Bouthry E Abstract Prevention is an essential aspect of management of infections that can be transmitted from mother to fetus during pregnancy: The prescription and interpretation of serologic markers differ according to clinical context: screening, counts, clinical signs, or ultrasound signs. Testing for rubella IgG antibodies is recommended at the beginning of pregnancy, in the absence of written results proving either immunity or previous vaccination with two doses. Monthly serologic monitoring (IgG and IgM) is recommended for woman lacking immunity to toxoplasmosis. Diagnosis of a primary infection requires the concomitant detection of IgG and IgM. Nonetheless, the presence of specific IgM is not necessarily a marker of recent infection. IgG avidity ...
Thu, 07 May 2015 00:00:00 +0100(Source: Clinical and Experimental Ophthalmology)
Mon, 04 May 2015 18:45:39 +0100If you had chickenpox as a child, the virus that caused it can re-emerge later in life — out of the blue — to cause shingles. This condition, also known as herpes zoster, consists of a rash on one side of the body, often accompanied by excruciating pain. The rash typically goes away in about a month, but in some people, the pain lingers for weeks, months, or even years. This chronic pain is called post-herpetic neuralgia. The virus that causes chickenpox, known as varicella-zoster, doesn’t necessarily disappear from the body after the chickenpox rash fades away. Instead, the virus can go into hiding, taking up residence in the nerve roots coming off the spinal cord. As the immune system becomes weaker with age, varicella-zoster may “wake up,” start to grow in a nerve ...
Mon, 04 May 2015 12:21:49 +0100Varicella-zoster virus causes chickenpox in children and shingles in older adults. The virus typically remains dormant in patients with healthy immune systems, but can reactivate if the immune system is compromised. Patients infected with human immunodeficiency virus (HIV) can, in rare cases, experience bleeding on the brain that causes a type of stroke called intracerebral hemorrhage. (Source: ScienceDaily Headlines)
Fri, 01 May 2015 20:10:29 +0100Armagan Denli, three, died in North Middlesex Hospital, London, on April 19 from meningitis. His parents claim if doctors had not mistaken the infection for chickenpox he would still be alive. (Source: the Mail online | Health)
Thu, 30 Apr 2015 12:28:50 +0100WARNING: GRAPHIC CONTENT. A 32-year-old man from London uploaded a video showing a horrific case of adult chicken pox in which his entire body is covered in angry fluid-filled pustules. (Source: the Mail online | Health)
Wed, 01 Apr 2015 00:00:00 +0100Shingles (herpes zoster) is a common condition in which the virus that causes chickenpox (varicella-zoster virus) reactivates after years of lying dormant in your body. As the virus reactivates, it causes pain and tingling and eventually a rash of short-lived blisters. "Shingles normally isn't a serious condition, but in some people the rash can cause [...] (Source: News from Mayo Clinic)
Mon, 30 Mar 2015 00:00:00 +0100Varicella-zoster virus (VZV) causes chickenpox and shingles, and is found in human populations worldwide. The lack of temporal signal in the diversity of VZV makes substitution rate estimates unreliable, which is a barrier to understanding the context of its global spread. Here, we estimate rates of evolution by studying live attenuated vaccines, which evolved in 22 vaccinated patients for known periods of time, sometimes, but not always undergoing latency. We show that the attenuated virus evolves rapidly (~10–6 substitutions/site/day), but that rates decrease dramatically when the virus undergoes latency. These data are best explained by a model in which viral populations evolve for around 13 days before becoming latent, but then undergo no replication during latency. This implies ...
Wed, 11 Mar 2015 00:00:00 +0100(Source: Journal of Paediatrics and Child Health)
Tue, 10 Mar 2015 15:01:00 +0100Layton Boys-Hope, one, of Sunderland, woke up from a nap with a high temperature and trouble breathing after being ill with chickenpox. He died of a cardiac arrest in hospital the next day. (Source: the Mail online | Health)
Sun, 01 Mar 2015 00:00:00 +0100Orofacial acute herpes zoster or shingles affects the trigeminal nerve and represents the reactivation of the varicella zoster virus (VZV) that has lain dormant in the trigeminal nerve root ganglion after exposure to or the clinical manifestation of chickenpox. The presentation, evaluation and diagnosis, and treatment of orofacial acute herpes zoster were discussed, along with the role of the dental professional in managing these patients. (Source: Dental Abstracts)
Thu, 26 Feb 2015 19:18:09 +0100Authors: Nagel MA, Gilden D Abstract Varicella zoster virus (VZV) infects >95 % of the world population. Typically, varicella (chickenpox) results from primary infection. The virus then becomes latent in ganglionic neurons along the entire neuraxis. In immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles), pain, and rash in 1-2 dermatomes. Multiple case reports showed a link between stroke and zoster, and recent studies have emerged which reveal that VZV infection of the cerebral arteries directly causes pathological vascular remodeling and stroke (VZV vasculopathy). In the past few years, several large epidemiological studies in Taiwan, Denmark, and the U.K. demonstrated that zoster is a risk factor for stroke and that antiviral therapy may reduce ...
Wed, 25 Feb 2015 00:00:00 +0100Abstract Varicella zoster virus (VZV) infects >95 % of the world population. Typically, varicella (chickenpox) results from primary infection. The virus then becomes latent in ganglionic neurons along the entire neuraxis. In immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles), pain, and rash in 1–2 dermatomes. Multiple case reports showed a link between stroke and zoster, and recent studies have emerged which reveal that VZV infection of the cerebral arteries directly causes pathological vascular remodeling and stroke (VZV vasculopathy). In the past few years, several large epidemiological studies in Taiwan, Denmark, and the U.K. demonstrated that zoster is a risk factor for stroke and that antiviral therapy may reduce this risk. Herein, the h...
Thu, 19 Feb 2015 03:31:54 +0100The virus that causes chickenpox and shingles may be related to a serious blood vessel problem later in life (Source: Health News: CBSNews.com)
Wed, 11 Feb 2015 18:09:26 +0100Seated in an exam room on the sixth floor of Boston Children’s Hospital, Sung-Yun Pai, MD, speaks mother-to-mother—not doctor to patient’s mother—with Marcela Caceres, who has just asked whether she should take extra precautions if her 4-year-old son Agustin is exposed to chickenpox. The answer is no. “I’m a mother too, and a good mother also knows when to back off,” Pai tells her. “It’s important for him to have a normal life.” “It’s hard for me to really accept that that’s the case,” Caceres says, “but I’m working on it.” If Caceres has trouble shedding her instinct to over-protect, it’s for good reason. Agustin was born with X-linked severe combined immune deficiency (SCID-X1)—“bubble boy” disease—and it can be difficult for Caceres to believe...
Mon, 09 Feb 2015 22:29:57 +0100By: Tia Ghose, Rachael Rettner and Tanya Lewis Published: 02/06/2015 10:17 AM EST on LiveScience The U.S. measles outbreak now includes at least 102 infected people in 14 states. Most of the cases have been tied to Disneyland in Southern California. The outbreak has many people wondering why a disease that was eradicated from the United States in the year 2000 is now infecting so many people, and what role vaccination requirements may have had in the outbreak. We asked experts to explain how the vaccine works and why the outbreak is happening now. Why is the outbreak happening now? Most of the cases of measles reported so far in 2015 are part of a large, ongoing outbreak linked to Disneyland in Anaheim, California, according to the California Department of Public Health(CDPH). The theme...
Sun, 08 Feb 2015 00:00:00 +0100Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Randall J. Cohrs Varicella zoster virus (VZV) is a ubiquitous human herpesvirus typically causing childhood varicella (chickenpox) at which time a life-long latent infection is established in ganglionic neurons throughout the neuraxis. Reactivation of latent virus, typically in the elderly and immunocompetent usually causes zoster (shingles) but can also result in serious neurologic disease. In cases of vasculopathy, meningoencephalitis and myelitis where VZV is suspected, diagnosis requires detection of virus DNA or antibody in CSF. In collaboration with NASA, VZV DNA was found in saliva of health astronauts suggesting asymptomatic virus reaction due to the stress of spaceflight. T...
Sat, 07 Feb 2015 00:24:38 +0100LOS ANGELES (AP) — Students entering the University of California system in 2017 will have to be vaccinated against measles and other diseases under new immunization rules announced Friday. The change, which had been in the works before the latest measles outbreak, has taken on new urgency after infections that originated at Disneyland in December spread to communities in half a dozen states and Mexico. Most who fell ill were not vaccinated. UC currently requires students to be inoculated only against hepatitis B, although some individual campuses have stricter immunization rules. The new plan will require students to be screened for tuberculosis and vaccinated for measles, chickenpox, whooping cough, meningitis and tetanus. "The University of California is committed to protecting the ...
Fri, 06 Feb 2015 02:09:12 +0100Half of U.S. states don't require home-school students to be vaccinated against diseases that include measles, chickenpox and hepatitis B, according to an organization that advocates greater oversight of home schooling. While public schools require students to get a number of vaccinations before entering kindergarten, there's no mandate for home-schooled children in 25 states, according to the Coalition for Responsible Home Education. About 3 percent of the U.S. school-age population was home-schooled in 2011-2012, according to the U.S. Education Department. Amid a recent measles outbreak that has infected more than 100 people in 15 states, politicians, public health officials and researchers have called on parents to vaccinate their children. Forty-eight states require public school ...
Wed, 28 Jan 2015 00:00:00 +0100We describe a polyclonal CD8+ T cell response with elevated pro-inflammatory cytokines and a fivefold upregulation of the high-affinity Fc receptor type I (CD64) on granulocytes. Early consideration of FUMHD in the differential diagnosis of a systemic inflammatory disease combined with a generalized necrotizing rash is important for early and adequate management of children with this rare and challenging disease. (Source: Infection)
Wed, 21 Jan 2015 12:00:39 +0100Healthcare staff should warn pregnant women who have not had chicken pox not to expose themselves to the condition. You must sign in to continue reading this article Hide related content: Show related content read more (Source: Nursing in Practice)
Wed, 21 Jan 2015 08:08:38 +0100Pregnant women who have not had chicken pox should be advised to avoid people who have the virus and be referred to a specialist if they develop the rash, the Royal College of Obstetricians and Gynaeocologists (RCOG) has said. (Source: The Independent - Science)
Wed, 21 Jan 2015 08:08:38 +0100Pregnant women who have not had chicken pox should be advised to avoid people who have the virus and be referred to a specialist if they develop the rash, the Royal College of Obstetricians and Gynaeocologists (RCOG) has said. (Source: The Independent - Science)
Tue, 20 Jan 2015 18:54:57 +0100Descreveu-se aqui o caso de um homem de 30 anos de idade com quadro de varicela grave, hipoxemia refratária, vasculite do sistema nervoso central e insuficiência renal anúrica. Foi necessário transporte por ambulância com suporte respiratório extracorpóreo veno-venoso, sendo este utilizado até a recuperação do paciente. Discute-se o potencial uso de oxigenação por membrana extracorpórea em países em desenvolvimento para o controle de doenças comuns nestas áreas.A case of a 30 year-old man presenting with severe systemic chickenpox with refractory hypoxemia, central nervous system vasculitis and anuric renal failure is described. Ambulance transportation and support using veno-venous extracorporeal membrane oxygenation ...
Fri, 16 Jan 2015 19:10:24 +0100When the nation turned our eyes to watch the ball drop in Times Square on New Year's Eve, we saw actress and former Playboy Playmate Jenny McCarthy urging viewers to kiss her on our TV screens. Thousands of people did, and sent her pictures to prove it. That's the nature of being a celebrity, possessing the ability to influence other people's behavior, and therein lies its potential for abuse. The idea that vaccines cause autism has been found to be totally false by doctors and scientists, in the same way almost all sane observers agree global warming is manmade. But thanks to anti-vaccine misinformation spread by some celebrities like McCarthy, Miyam Bialik, and Donald Trump, doctors say preventable diseases like measles are making a comeback across America, and children are dying fro...
Thu, 15 Jan 2015 12:37:24 +0100Postherpetic neuralgia (PHN) is the same virus that causes chickenpox. During the initial infection of chickenpox, the virus remains in the person's body, lying dormant inside nerve cells. Years later, illness, age, stress, medications, or decreased immune system function may reactivate the virus and cause a shingles outbreak. At times, there is no apparent reason for the outbreak. (Source: Disabled World)
Mon, 12 Jan 2015 06:00:00 +0100(NaturalNews) Once again, the completely illogical debacle concerning the world of vaccinations has surfaced.By now, you know they've come under fire by those who are adamant that they do more harm than good. Countless people have developed irreversible health problems and even... (Source: NaturalNews.com)
Wed, 17 Dec 2014 03:55:47 +0100Chickenpox, mumps and whooping cough seem to keep striking where they're least expected (Source: Health News: CBSNews.com)
Mon, 15 Dec 2014 18:03:39 +0100Actress Angelina Jolie is missing the premiere of her own film Unbroken because she says she has been diagnosed with chickenpox. (Source: WDSU.com - Health)
Mon, 15 Dec 2014 16:54:23 +0100Angelina Jolie delivered a special message to fans in a video posted to YouTube: She's got chickenpox. (Source: CNN.com - Health)
Mon, 15 Dec 2014 12:23:33 +0100Angelina Jolie delivered a special message to fans in a video posted to YouTube: She's got chickenpox. (Source: CNN.com - Health)