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MedWorm: Syphilis



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Syphilis category.



Last Build Date: Tue, 29 Mar 2016 16:30:17 +0100

 



HIV and syphilis

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: HIV-infected people are at increased risk for syphilis, partially because of their immunodeficiency, but particularly because of ease of transmission of syphilis in sexually active people. Unlike HIV, syphilis can readily be transmitted through insertive or receptive oral sex. HIV-infected individuals, particularly men who have sex with men with multiple partners and male or female sex workers tend to have higher rates of HIV, syphilis and co-infection than the general population in their respective communities worldwide. (Source: International Journal of Infectious Diseases)

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Rapid diagnostic point of care tests in resource limited settings

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: One of the definitions of diagnostic point of care testing is provision of laboratory testing at or near the site of patient care. It has the potential to minimise the time to obtain the result of the test, which expedites the diagnosis and initiation of the treatment especially in resource-limited settings where health care infrastructure is weak and access to quality and timely medical care represents a challenge. It is estimated, that introduction of rapid, laboratory-independent diagnostic tests for four diseases (syphilis, malaria, tuberculosis and bacterial pneumonia) in developing countries could prevent more than 1.2 million deaths annually. (Source: International Journal of Infectious Diseases)



Secondary syphilis manifesting as annular lichenoid plaques

Tue, 29 Mar 2016 09:23:38 +0100

We present the case of a 24-year-old man presenting with annular lichenoid lesions over face (Source: International Journal of Infectious Diseases)



Congenital Syphilis: Complicating an already complex adoption process

Tue, 29 Mar 2016 09:23:36 +0100

We present the story of an apparently asymptomatic orphan whose VDRL returned positive on a routine adoption screen. (Source: International Journal of Infectious Diseases)



An Open Letter to the Boston Globe About Lyme Disease

Mon, 28 Mar 2016 19:45:00 +0100

Today, the Boston Globe editorial board spoke out against a bill "that would require insurers in Massachusetts to cover Lyme disease treatments for as long as a doctor says they're needed." The Globe writes: Lawmakers may have good intentions, but they don't possess the expertise to decide whether it's beneficial, cost-efficient, or safe, to keep using strong medicines to treat a condition the medical establishment doubts is real. Such questions should be resolved by a consensus of doctors and researchers -- and buttressed by convincing clinical date [sic] -- not determined by legislative mandate. Who among the Boston Globe editorial board possesses the medical expertise to make this call is not disclosed, but this information would be useful given that the Globe's stance presumes absolute...



Risk factors associated with incident sexually transmitted infections in HIV‐positive patients in the Australian HIV Observational Database: a prospective cohort study

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsIn this cohort of individualsbeing treated with antiretroviral drugs, those who were MSM, who were 30–39 years old, and who had a prior history of STI, were at highest risk of a further STI diagnosis. (Source: HIV Medicine)

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Tertiary syphilis: tubero-serpiginous and tubero-ulcerous syphilids

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:The Brazilian Journal of Infectious Diseases Author(s): Lívia Montelo Araújo Jorge, José Augusto da Costa Nery, Fred Bernardes Filho (Source: The Brazilian Journal of Infectious Diseases)



Nigeria: Borno State Has Highest Rate of Syphilis - Expert

Fri, 25 Mar 2016 10:07:45 +0100

[This Day] The Head of Prevention, Department of Public Health and HIV/AIDS Division, Ministry of Health, Dr. Chukwuma Anyaike, has disclosed that recent findings from a national survey on serial prevalence of Syphilis in the country indicates that Borno State remains the state with highest cases of Syphilis. (Source: AllAfrica News: HIV-Aids and STDs)



Association between sexually transmitted disease and church membership. A retrospective cohort study of two Danish religious minorities

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions The cohort shows significant lower incidence of STD, most likely including human papillomavirus, which may partly explain the lower incidence of cancers of the cervix, rectum, anus, head and neck. (Source: BMJ Open)



Diagnostic Accuracy of Rapid Tests for STIs in WomenDiagnostic Accuracy of Rapid Tests for STIs in Women

Wed, 23 Mar 2016 04:41:49 +0100

How accurate are rapid diagnostic tests for chlamydia, gonorrhea, and syphilis in women having symptoms of lower urinary tract infection? Sexually Transmitted Infections (Source: Medscape Pathology Headlines)



Vintage public health posters show attitudes towards disease prevention

Tue, 22 Mar 2016 16:30:17 +0100

The prints were created to halt the spread of syphilis and tuberculosis, and to encourage people to eat a good diet and exercise. They are stored at the Library of Congress, Washington DC. (Source: the Mail online | Health)

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Factors associated with syphilis infection: a comprehensive analysis based on a case-control study

Tue, 22 Mar 2016 13:34:21 +0100

Research Articles Y. XIAO, S.-L. LI, H.-L. LIN, Z.-F. LIN, X.-Z. ZHU, J.-Y. FAN, K. GAO, H.-L. ZHANG, L.-R. LIN, L.-L. LIU, M.-L. TONG, J.-J. NIU, T.-C. YANG, Epidemiology & Infection, Volume 144 Issue 06, pp 1165-1174Abstract (Source: Epidemiology and Infection)



Atypical Cutaneous Manifestations in Syphilis

Mon, 21 Mar 2016 23:00:00 +0100

Publication date: Available online 21 March 2016 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): M. Ivars Lleó, P. Clavo Escribano, B. Menéndez Prieto Although the diversity of the clinical manifestations of syphilis is well-known, atypical presentations can also occur. Such atypical presentations are associated with a high risk of transmission as a result of diagnostic confusion and treatment delays owing to the disease's ability to mimic other common skin diseases, deviate from classic clinical presentations, and adopt unique forms. Cases of atypical syphilis have been described most frequently in patients with concomitant human immunodeficiency virus (HIV) infection. Because the incidence of syphilis has been growing over recent years —particularly in patients ...



Acquired Syphilis With Anemia and Leukoerythroblastic Reaction: A Case Report.

Mon, 21 Mar 2016 23:00:00 +0100

Authors: Mantripragada KC, Fircanis Rizk S, Reagan JL, LeGolvan M PMID: 26999776 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)



Reduced Treponema pallidum-Specific Opsonic Antibody Activity in HIV-Infected Patients With Syphilis

Sat, 19 Mar 2016 00:00:00 +0100

Conclusions. Serum T. pallidum–specific opsonic activity is significantly lower in HIV-infected individuals. Impaired T. pallidum–specific immune responses could contribute to differences in the course of disease or treatment response. (Source: The Journal of Infectious Diseases)



Syphilis Among U.S.-Bound Refugees, 2009–2013

Fri, 18 Mar 2016 00:00:00 +0100

Abstract U.S. immigration regulations require clinical and serologic screening for syphilis for all U.S.-bound refugees 15 years of age and older. We reviewed syphilis screening results for all U.S.-bound refugees from January 1, 2009 through December 31, 2013. We calculated age-adjusted prevalence by region and nationality and assessed factors associated with syphilis seropositivity using multivariable log binomial regression models. Among 233,446 refugees, we identified 874 syphilis cases (373 cases per 100,000 refugees). The highest overall age-adjusted prevalence rates of syphilis seropositivity were observed among refugees from Africa (1340 cases per 100,000), followed by East Asia and the Pacific (397 cases per 100,000). In most regions, male sex, increasing age, and living...

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Investigating HIV Infection and HIV Incidence Among Chinese Men Who Have Sex with Men with Recent Sexual Debut, Chongqing, China, 2011

Wed, 16 Mar 2016 00:00:00 +0100

Abstract HIV among men who have sex with men (MSM) with recent male–male sexual debut, such as within the past 5 years, may be a proxy for recent HIV infection. Using this definition, we explored factors associated with HIV infection in this group to understand the evolving HIV epidemic among MSM in Chongqing. We conducted a cross-sectional respondent-driven sampling survey among Chongqing MSM in 2011. Computer-assisted, self-administered questionnaires were used and blood specimens were collected for HIV and syphilis testing. Three hundred and ninety-one unique MSM were recruited of which 65.7 % (257) had their sexual debut with another man in the past 5 years. HIV prevalence among men with recent sexual debut was 18.7 % suggesting a possible HIV incidence of 3.7 %. Mu...



Cerebrospinal fluid examination may be useful in diagnosing neurosyphilis in asymptomatic HIV+ patients with syphilis

Tue, 15 Mar 2016 22:22:28 +0100

ABSTRACT Lumbar puncture in neurologically asymptomatic HIV+ patients is still under debate. There are different criteria for detecting neurosyphilis through cerebrospinal fluid (CSF), especially in cases that are negative through the Venereal Disease Research Laboratory (VDRL), regarding cellularity and protein content. However, a diagnosis of neurosyphilis can still exist despite negative VDRL. Treponema pallidum hemagglutination assay (TPHA) titers and application of the TPHA index in albumin and IgG improve the sensitivity, with a high degree of specificity. Thirty-two patients were selected for this study. VDRL was positive in five of them. The number of diagnoses reached 14 when the other techniques were added. It was not determined whether cellularity and increased protein levels we...



Synergistic cytotoxic effects of combined δ-tocotrienol and jerantinine B on human brain and colon cancers

Tue, 15 Mar 2016 00:00:00 +0100

Conclusion The present study demonstrated the mechanism for cytotoxic potency of δ-tocotrienol and jerantinine B against U87MG and HT-29 cells. Furthermore, combined low-dose treatments induced concurrent synergistic inhibition of cancer cell growth with concomitant dose reduction thus minimizing toxicity to normal cells and improving potency of δ-tocotrienol and jerantinine B. Graphical abstract (Source: Journal of Ethnopharmacology)



Influence of Detection Method and Study Area Scale on Syphilis Cluster Identification in North Carolina

Sun, 13 Mar 2016 19:07:07 +0100

Conclusions: Our results underscore the importance of selecting the correct scale for analysis to more precisely identify areas with high disease burden. A more complete understanding of high-burden cluster location can inform resource allocation for geographically targeted sexually transmitted infection interventions. (Source: Sexually Transmitted Diseases)



HIV Incidence Among Men Who Have Sex With Men After Diagnosis With Sexually Transmitted Infections

Sun, 13 Mar 2016 19:07:07 +0100

Conclusions: Men who have sex with men diagnosed as having rectal gonorrhea and early syphilis were at the greatest risk for being diagnosed as having HIV infection after STI diagnosis. These men should be prioritized for more intensive prevention interventions, including PrEP. (Source: Sexually Transmitted Diseases)

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The Prevalence of Syphilis From the Early HIV Period Is Correlated With Peak HIV Prevalence at a Country Level

Sun, 13 Mar 2016 19:07:07 +0100

Conclusions: Syphilis prevalence in the 1990s predicted approximately 53% of the variation in peak HIV prevalence. Populations with generalized HIV epidemics had a higher prevalence of syphilis in the pre-HIV period. This finding provides additional rationale to carefully monitor sexual behavior, sexual networks, and sexually transmitted infection incidence in these populations. (Source: Sexually Transmitted Diseases)



The etiology of congenital nephrotic syndrome: current status and challenges.

Sat, 12 Mar 2016 19:04:02 +0100

CONCLUSION: At present, the main challenge in CNS is to identify the cause of disease for individual patients. To make a definitive diagnosis, with the exclusion of infection-related CNS and maternal-associated disorders, pathology, family history, inheritance mode, and other accompanying congenital malformations are sometimes, but not always, useful indicators for diagnosing genetic CNS. Next-generation sequencing would be a more effective method for diagnosing genetic CNS in some patients, however, there are still some challenges with next-generation sequencing that need to be resolved in the future. PMID: 26961288 [PubMed - in process] (Source: World Journal of Pediatrics : WJP)



Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015.

Fri, 11 Mar 2016 14:54:02 +0100

Authors: Talley P, Holzbauer S, Smith K, Pomputius W Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. A rapid influenza assay was negative, and erythrocyte sedimentation rate and total white blood cell count were normal. She improved with symptomatic care at home, but returned to her pediatrician's office on April 28, reporting recurrence of her headache and photophobia and new onset of a stiff neck. She was admitted to the hospital, where she was febrile to 102.9°F (39.4°C) and had meningismus. Computed tomography scan of her head was normal, and a cerebrospinal fluid (CSF) analysis showed a markedly elevated white blood cell count with 68% lymphocytes, low glucose...



Molecules, Vol. 21, Pages 331: Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology

Thu, 10 Mar 2016 00:00:00 +0100

Eurycoma longifolia Jack (known as tongkat ali), a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria) in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever. Mostly, the roots extract of E. longifolia are used as folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recove...



Early Postnatal Diagnosis of Congenital Syphilis: Contribution of a Comparative Western Blot Method.

Wed, 09 Mar 2016 00:00:00 +0100

Authors: Marangoni A, Foschi C, Capretti MG, Nardini P, Compri M, Corvaglia LT, Faldella G, Cevenini R Abstract Serology has a pivotal role in the diagnosis of congenital syphilis (CS), but problems arise because of the passive transfer of IgG antibodies across the placenta.The aim of this study was to assess the diagnostic value of a comparative Western Blot (WB) method finalized to match IgG immunological profiles of mothers and their own babies at birth, in order to differentiate between passively transmitted maternal antibodies and antibodies synthesized by the infants against Treponema pallidum.Thirty infants born to mothers with unknown or inadequate treatment for syphilis entered in a retrospective study, conducted at St. Orsola-Malpighi Hospital, Bologna, Italy.All the infa...

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Co‐infection assessment in HBV, HCV, and HIV patients in Western Saudi Arabia

Tue, 08 Mar 2016 00:00:00 +0100

To estimate the prevalence of diagnosed and undiagnosed coinfections among HIV, HBV, and HCV infected patients. Retrospective analysis of laboratory records for HIV, HBV, and HCV patients presenting at the HIV outpatient clinic. Serological data including hepatitis B surface antigen (HBsAg), hepatitis B e‐antigen (HBeAg), hepatitis B e‐antibody (anti‐HBe), antibodies to HIV and HCV, anti‐toxoplasmosis IgG and IgM antibodies, and anti‐syphilis antibodies (VDRL) were collected. We obtained data for 628 (218 HCV, 268 HBV, and 142 HIV) patients. Male‐to‐female ratios were 1:1 for HCV, 3:4 for HBV, and 5:3 for HIV. Age means (SD) were 54.24 (16.40), 44.53 (18.83), and 40.39 (15.92) years for HCV, HBV, and HIV, respectively. In HIV group, the prevalence of HBV and HCV coinfections ...



The continuing threat of syphilis in pregnancy

Sun, 06 Mar 2016 18:07:17 +0100

Purpose of review: Syphilis in pregnancy continues to be a worldwide threat to mothers and their fetuses, and in recent years has been increasing in prevalence. The purpose of this short review is to address current issues in the diagnosis and management of syphilis complicating pregnancies. Recent findings: Maternal syphilis infections and congenital syphilis appear to be increasing in both high and low resource settings. Treponema pallidum ssp. pallidum, the causative spirochete of syphilis, remains one of the few human infectious pathogens that has not been successfully cultured, making identification difficult and research in targeted antimicrobial therapies challenging. Fortunately, syphilis remains sensitive to penicillin, which remains the foundational therapy for this infection. P...



Erythema multiforme caused by sildenafil in an HIV(+) subject.

Sun, 06 Mar 2016 11:42:02 +0100

Authors: Pitsios C Abstract Erythema multiforme is mainly caused by drug allergy and infections. This is the case of a HIV-positive, 49-year-old male, recently cured for syphilis, that presented erythema multiforme minor, five days after taking sildenafil. He had a fast recovery, only with the use of antihistamines. Cell-mediated allergy to sildenafil was confirmed six months later, with the use of patch-tests. PMID: 26934741 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)



The Presentation, Diagnosis, and Treatment of Sexually Transmitted Infections.

Sat, 05 Mar 2016 15:32:02 +0100

CONCLUSION: Sexually transmitted infections are common around the world, and any such infection increases the patient's risk of contracting other types of sexually transmitted infection. Molecular genetic diagnostic techniques should be made widely available. PMID: 26931526 [PubMed - in process] (Source: Deutsches Arzteblatt International)



[Syphilis: Prevalence in a Hospital in Lisbon].

Thu, 03 Mar 2016 16:03:02 +0100

CONCLUSION: Syphilis remains an important public health problem. It is necessary to establish education programs, screening and follow-up strategies to reduce their prevalence and to perform more efficient screening of the partners. PMID: 26926899 [PubMed - in process] (Source: Acta Medica Portuguesa)

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The role of PET/CT in diagnosing generalized lymphadenopathy in asymptomatic secondary syphilis.

Thu, 03 Mar 2016 09:07:02 +0100

CONCLUSION: We report a case of a secondary syphilis in a patient with generalized lymphadenopathy detected by fluorine-18-fluorodeoxy glucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) images without any clinical symptom. Clinical examination found an ulcer on his penis and serologic tests set the diagnosis of an early stage of secondary syphilis. PMID: 26929943 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)



Do you have Syphilis? Shock rise in STIs among over 45s...and ONLINE DATING is to blame

Thu, 03 Mar 2016 04:28:00 +0100

NEW FIGURES have revealed there’s been a rise in the number of sexually transmitted infections in older adults between 45-65 year olds. (Source: Daily Express - Health)



The incidence of congenital syphilis in the United Kingdom: February 2010 to January 2015

Wed, 02 Mar 2016 00:00:00 +0100

ConclusionThe incidence of congenital syphilis is controlled and monitored by healthcare services and related surveillance systems, and is now below the WHO elimination threshold. However, reducing the public health impact of this preventable disease in the UK is highly dependent on the successful implementation of WHO elimination standards across Europe. Tweetable abstractCongenital syphilis incidence in the UK is at a very low level and well below the WHO elimination threshold. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)



The incidence of congenital syphilis in the United Kingdom: February 2010 to January 2015.

Wed, 02 Mar 2016 00:00:00 +0100

CONCLUSION: The incidence of congenital syphilis is controlled and monitored by healthcare services and related surveillance systems, and is now below the WHO elimination threshold. However, reducing the public health impact of this preventable disease in the UK is highly dependent on the successful implementation of WHO elimination standards across Europe. TWEETABLE ABSTRACT: Congenital syphilis incidence in the UK is at a very low level and well below the WHO elimination threshold. PMID: 26931054 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)



Syphilis sparks concern in popular vacation city

Tue, 01 Mar 2016 19:15:52 +0100

Spike in cases is tied to social media related hook-ups, less condom use and other factors (Source: Health News: CBSNews.com)

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Is Active SETI Really Dangerous?

Tue, 01 Mar 2016 18:14:09 +0100

In general, when we think about scientific inquiry, much of its power rests in the idea that everything is open to question. Turning a scientific gaze upon the world enlightens us and opens our potential to understand more deeply, while often challenging us to reconsider previously held beliefs and ideas. But science is not an unambiguously moral good. Einstein questioned the ethics of building the atomic bomb. We know that research like the Tuskegee study of syphilis in African Americans has deep moral problems related to racism and informed consent. More recently, Stephen Hawking and others have raised ethical questions about whether or not we should engage in sending messages to the stars -- the risks of letting ET know we're here may outweigh the benefits of making contact if ET happe...



Trends of Venereal Infections among Healthy Blood Donors at Karachi.

Tue, 01 Mar 2016 00:00:00 +0100

CONCLUSION: The prevalence of venereal infection was higher in replacement donors as compared with voluntary donors. The prevalence of syphilis in our series was high compared with earlier studies. It emerges that syphilis positivity rate appears to escalate; however, HIV infection remains static over a decade. Higher prevalence in younger donors is alarming and adversely affects the prospective blood donation pool. Stringent donor selection, emphasis on voluntary donation, and vigilant donors screening are highly recommended to ensure the maximum safety of blood recipient. PMID: 26923891 [PubMed - as supplied by publisher] (Source: Archives of Iranian Medicine)



Rare case of asymptomatic spontaneous coronary artery dissection

Sun, 28 Feb 2016 00:00:00 +0100

We present a case of a 46-year-old woman who presented to the emergency room after a syncopal episode. Most of her initial workup did not lead to any diagnosis. However, the transthoracic echocardiogram showed new onset left ventricular dysfunction. Further, cardiac evaluation showed a chronic coronary artery dissection in the proximal left anterior descending artery. Syncope was related to vasovagal event but rapid plasma reagin being positive led to the question of whether the coronary artery dissection was secondary to vasculitic manifestation of prior syphilis infection. More research is needed to answer this question and to find such an association.



Fulminant proliferative vitreoretinopathy in syphilitic uveitis

Sat, 27 Feb 2016 00:00:00 +0100

Conclusions Syphilitic uveitis may be complicated by complex RD/fulminant fibroglial proliferation, occurring during/after treatment. Predisposing factors are currently unknown but may include prior use of corticosteroid, necrotizing retinitis and/or high spirochaetal load. A significant inflammatory component may underlie this fulminant fibroglial proliferation, being possibly amenable to modulation by aggressive anti-inflammatory therapy delivered concurrently with parenteral antibiotics. (Source: Journal of Ophthalmic Inflammation and Infection)



Uveitis in São Paulo, Brazil: 1053 New Patients in 15 Months.

Fri, 26 Feb 2016 14:09:01 +0100

CONCLUSIONS: The current results can help determine the present epidemiology of uveitis and its changes over time in Brazil and increases essential information about the disease. Many uveitic entities are curable and visual damage can be prevented or limited if treated early and appropriately. PMID: 26914347 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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San Francisco officials vote to give condoms to middle schoolers

Fri, 26 Feb 2016 00:26:17 +0100

Health official said in a letter that San Francisco has among the highest rates of chlamydia, gonorrhea and syphilis of any city in the U.S. (Source: Health News: CBSNews.com)



Application of the Extended Health Control Belief Model to Predict Hepatitis A and B Vaccinations

Fri, 26 Feb 2016 00:00:00 +0100

ConclusionDespite free vaccinations offered in an easily accessible community setting, the majority of participants failed to complete the hepatitis vaccine series. More effort is needed to get adult men to participate in hepatitis vaccination clinics. Additional research is necessary to understand barriers other than cost to adults receiving vaccination. (Source: Public Health Nursing)



Lower HIV Risk Among Circumcised Men Who Have Sex With Men in China: Interaction With Anal Sex Role in a Cross-Sectional Study

Thu, 25 Feb 2016 15:19:42 +0100

Conclusions: Circumcised MSM were less likely to have acquired HIV, most pronounced among men predominantly practicing insertive anal intercourse. A clinical trial is needed. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)



[Media Watch] Mind the microbes

Wed, 24 Feb 2016 02:20:41 +0100

In 1822, French physician Antoine Laurent Bayle described a disease that is now called general paresis. Accompanied by delusions, mania, and dementia, the disease was common in the 19th century. At the time, doctors believed general paresis to be like any other mental illness—a punishment for depravity. But in 1857, on the basis of a statistical analysis of patients with paresis, German doctors Johannes Friedrich Esmark and W Jessen suggested syphilis as the cause. In the following years, evidence accrued that syphilis might cause paresis, such as when Treponema pallidum, the bacteria that causes syphilis, was isolated from the brains of patients with paresis. (Source: The Lancet Infectious Diseases)



Diagnostic value of color-coded duplex sonography in patients with ischemic stroke and congenital changes in the circle of Willis

Tue, 23 Feb 2016 00:00:00 +0100

Publication date: Available online 11 February 2016 Source:Cor et Vasa Author(s): I. Staikov, I. Stoyanov, M. Staneva, N. Neykov, G. Kirova, P. Polomski, I. Petrov The circle of Willis (CoW) forms the main circulatory system in the human brain. A large number of variations of the CoW is known, and also their association with ischemic stroke. Three cases of young patients with combination of ischemic stroke and anomalies in the CoW are presented, and the value of the color-coded duplex sonography (CCDS) is compared to other imaging diagnostics such as magnetic resonance angiography (MRA) and digital subtraction angiography (DSA). In these patients we found multiple risk factors such as stenosis or thrombosis of intracranial brain vessels, mechanical compression of vessels, a geneti...

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Co‐infection assessment in HBV, HCV and HIV patients in western Saudi Arabia

Sat, 20 Feb 2016 08:19:07 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)



Dental Stigmata of Congenital Syphilis: A Historic Review With Present Day Relevance

Sat, 20 Feb 2016 00:00:00 +0100

Abstract Syphilis was the first sexually transmitted disease to be diagnosed in childhood. Most developed countries controlled syphilis effectively after the 1950s and congenital syphilis became rare. Since the late 1990s there has been a resurgence of syphilis in developed and developing countries and the WHO estimates that at least half a million infants die of congenital syphilis every year. The earliest reference to the dental manifestations of congenital syphilis was by Sir Jonathan Hutchinson, Assistant Surgeon at The London Hospital in 1861. Three main dental defects are described in congenital syphilis; Hutchinson’s incisors, Moon’s molars or bud molars, and Fournier’s molars or mulberry molars. Although many physicians, dentists, and pathologists in developed countr...



Lyme: The Infectious Disease Equivalent of Cancer, Says Top Duke Oncologist

Fri, 19 Feb 2016 16:50:57 +0100

Last week, I mentioned the case of Dr. Neil Spector, whose long-undiagnosed Lyme Disease resulted in irreversible heart failure and ultimately, a heart transplant. Dr. Spector, author of Gone in a Heartbeat: A Physician's Search for True Healing, is the Sandra Coates Associate Professor of Medicine and Associate Professor of Pharmacology and Cancer Biology at Duke University School of Medicine. As the Director of Developmental Therapeutics at the Duke Cancer Institute, he's a leader in applying translational research to the clinical development of molecularly targeted personalized cancer therapies. Here, Dr. Spector shares his story, explains what Lyme and cancer have in common (hint: a LOT), and encourages us with his vision for the future. Like so many of us, your Lyme was missed by mu...



Abnormal Presentation of Early Syphilis as Dyspareunia in Adolescent Female

Fri, 19 Feb 2016 14:08:29 +0100

Syphilis (SP) is a sexually transmitted infection caused by the spirochete Treponema pallidum and has 4 distinguishable stages once acquired (primary, secondary, latent and tertiary). Primary SP normally presents with a painless, indurated genital ulcer at site of inoculation, 9-90 days after exposure to the disease. It is usually accompanied by non-tender inguinal nodes. There have been few case reports on atypical presentation of primary SP, including an erythematous nodule on the nipple and tonsillar chancres. (Source: Journal of Pediatric and Adolescent Gynecology)



Highlights from this issue

Thu, 18 Feb 2016 00:00:00 +0100

Syphilis, has always been known the "protean" disease, capable of manifesting in many forms and deceiving physicians as to its true nature. It confused Hunter, whose inoculation experiments1 were the forerunner of the Tuskegee and Guatemala experiments2—it is disputed whether he experimented on himself, but not that he inoculated others in support of a unitary theory of gonorrhoea and syphilis. The huge impact of syphilis on pre-penicillin public health together with its place at the centre of moral debate, and the difficulty of diagnosis made it central to paradigm shifts in the philosophy of science as described in Fleck's seminal work "The Genesis and Development of a Scientific Fact",3 first published in German in 1935. Many developed countries have seen a huge resurgence of syph...

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Secondary syphilis presenting with aortitis and coronary ostial occlusion

Thu, 18 Feb 2016 00:00:00 +0100

We report a rare case of aortitis with ostial occlusion and left ventricular failure in secondary syphilis. Her management required a true multidisciplinary approach from multiple specialities due to complications of concomitant psychosis and a history of anaphylaxis to penicillin. This case illustrates the complexities of diagnosing and managing a rare presentation of this increasingly prevalent infection. (Source: Sexually Transmitted Infections)



Painful and multiple anogenital lesions are common in men with Treponema pallidum PCR-positive primary syphilis without herpes simplex virus coinfection: a cross-sectional clinic-based study

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions Primary syphilis lesions are often painful and/or multiple in the absence of herpes coinfection, and may be clinically misdiagnosed. (Source: Sexually Transmitted Infections)



Detection of Treponema pallidum Sp. Pallidum DNA in Cerebrospinal Fluid (CSF) by Two PCR Techniques

Thu, 18 Feb 2016 00:00:00 +0100

ConclusionBeyond some limitations of the study, which are discussed here, both PCR techniques seem to be useful for the diagnosis of neurosyphilis, although 47‐PCR presents a higher sensitivity and polA‐PCR a higher specificity. (Source: Journal of Clinical Laboratory Analysis)



Make the Diagnosis: Infant's Mystery Eruptions

Wed, 17 Feb 2016 19:33:32 +0100

(MedPage Today) -- Case Findings: A 22-hour-old infant presented to a hospital in Haiti with pustules on the face and scalp. The infant showed no signs of distress, and was nursing. The mother has a history of syphilis. A nurse posted the image online, and more than 16,000 members of an online medical community responded to help. What is your diagnosis? (Source: MedPage Today Pediatrics)



Male Clients of Male Sex Workers in China: An Ignored High-Risk Population

Sun, 14 Feb 2016 18:34:58 +0100

Conclusions: The greater frequency of risk behaviors and high prevalence of HIV and syphilis indicated that HIV/syphilis prevention programs in China need to pay special attention to MCM as a distinct subgroup, which was completely ignored until date. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)

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Optic neuropathy secondary to syphilis in an HIV negative patient.

Sun, 14 Feb 2016 15:26:02 +0100

Authors: Berrozpe-Villabona C, Santos-Bueso E, Bañeros-Rojas P, Aguilar Munoa S, Saenz-Francés F, Díaz-Valle D, Martínez-de-la-Casa JM, García-Feijoo J Abstract Ocular syphilis is a resurgent clinical condition due to unsafe sexual practices. It has been reported in both immunocompromised and immunocompetent patients, but in HIV positive patients, it is more likely to exhibit a more aggressive course and adopt atypical clinical patterns such as optic nerve involvement. Herein we report an atypical case of optic neuritis secondary to syphilis in an HIV negative patient. This case highlights the importance of considering syphilis in the differential diagnosis of ocular inflammation and of obtaining HIV serology, since both diseases share common risk factors. PMID: 26868532 [...



Characteristics and factors influencing unprotected anal intercourse among men who have sex with men in fuyang, china.

Sat, 13 Feb 2016 16:55:02 +0100

The objective of this study was to explore the characteristics and factors influencing unprotected anal intercourse (UAI) among MSM in Fuyang, China in order to develop an intervention program to prevent the spread of HIV infection among MSM. We conducted this cross sectional study among 413 MSM in 2013. Participants completed an interviewer- administered questionnaire and were tested for HIV and syphilis infections. Three hundred fifty of 413 subjects reported sexual activity with a male partner during the previous 6 months; of these 27(7.7%) had unprotected sex. Forty-four subjects had sex with a female partner during the previous 6 months; of these 25 (58.1%) had unprotected sex. The frequency of having unprotected sex with a female was significantly greater than with a male (χ2 = 84.5...



Spatial modelling of perinatal mortality in Mchinji, Malawi

Sat, 13 Feb 2016 00:00:00 +0100

Conclusion: Targeting health interventions to higher risk areas and ensuring universal coverage are promising approaches for promoting equity and reducing perinatal mortality. Graphical abstract (Source: Spatial and Spatio-temporal Epidemiology)



A Comparison of Two Mathematical Modeling Frameworks for Evaluating Sexually Transmitted Infection Epidemiology

Thu, 11 Feb 2016 03:34:10 +0100

Conclusions: The frequency-dependent assumption is problematic when modeling short-term STIs. Frequency-dependent models tend to underestimate the importance of high-risk groups in sustaining STI epidemics, while overestimating the importance of long-term partnerships and low-risk groups. (Source: Sexually Transmitted Diseases)



Prevalence and Correlates of a Diagnosis of Sexually Transmitted Infection Among Young Aboriginal and Torres Strait Islander People: A National Survey

Thu, 11 Feb 2016 03:34:10 +0100

This article reports the prevalence of self-reported STI diagnoses and their correlates among Aboriginal people aged 16 to 29 years. Methods: Results were analyzed from a survey conducted between 2011 and 2013 at regular community events. Univariate and multivariate logistic regression models were used to identify the correlates of a history of STI diagnosis among participants who reported being sexually active and ever having been tested for STIs. All analyses were stratified by sex. Results: Of the 2877 participants in this study, 2320, comprising 60% females, self-reported ever having had vaginal or anal sex, and a further subset of 1589 (68%) reported ever being tested for any of the following STIs: chlamydia, gonorrhea, syphilis, or trichomonas. Within this latter group, the proport...

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Probable Syphilitic Aortitis Documented by Positron Emission Tomography

Thu, 11 Feb 2016 03:34:10 +0100

We describe the case of a patient with early latent syphilis with increased metabolic activity along the aorta detected via PET, suggesting probable aortitis. Three months after treatment, the PET showed apparent resolution of the aortitis. (Source: Sexually Transmitted Diseases)



What Is the Use of Rapid Syphilis Tests in the United States?

Thu, 11 Feb 2016 03:34:10 +0100

No abstract available (Source: Sexually Transmitted Diseases)



A Comparison of Two Mathematical Modeling Frameworks for Evaluating Sexually Transmitted Infection Epidemiology.

Thu, 11 Feb 2016 03:13:02 +0100

CONCLUSIONS: The frequency-dependent assumption is problematic when modeling short-term STIs. Frequency-dependent models tend to underestimate the importance of high-risk groups in sustaining STI epidemics, while overestimating the importance of long-term partnerships and low-risk groups. PMID: 26859800 [PubMed - in process] (Source: Herpes)



Prevalence and associated factors of HIV infection among men who have sex with men in Hefei, China, 2013-2014: a cross-sectional study

Thu, 11 Feb 2016 00:00:00 +0100

The objective of this study was to investigate the prevalence and influencing factors of HIV infection among men who have sex with men (MSM) in Hefei, China. A total of 578 MSM were recruited, with a mean age of 28.13 ± 6.91; 70.7% were under 30. The awareness rate was 95.4% (560/587) in the cross-sectional study. Of all the respondents, 73 (12.44%) were seropositive for HIV and 56 (9.54%) for syphilis. Multivariate analysis showed that self-reported sexually transmitted infections (STIs) (AOR = 8.02, 95% CI: 2.58–24.98, P < 0.001), received HIV testing in the past year (AOR = 0.33, 95% CI: 0.19–0.60, P < 0.001) and syphilis (AOR = 3.40, 95% CI: 1.69– 6.85, P = 0.001) were independently associated with HIV infection. It is necessary for post-test counselling ...



Seropositivity of TTIs among blood donors in Hail, Saudi Arabia, from 2014 to 2015

Wed, 10 Feb 2016 00:00:00 +0100

Conclusions The obtained data revealed that the seropositivity of hepatitis B virus, HCV, syphilis, HTLV-I/II, and HIV in Hail Region during the period under study were 8.6%, 7.2%, 4.7%, 2.2% and 0.8%, respectively. It is recommended to continue screening blood donors with highly specific and sensitive tests, to counsel donors who are positive to transfusion transmitted infections. (Source: Asian Pacific Journal of Tropical Disease)

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Clinicopathologic features, microvessel density, and immunohistochemical expression of ICAM-1 and VEGF in 15 cases of secondary syphilis with oral manifestations

Tue, 09 Feb 2016 00:00:00 +0100

Conclusions Expression of immunoinflammatory and vascular proteins was intense, suggesting their participation on the pathogenesis of oral secondary syphilis. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)



Barriers and enablers to integrating maternal and child health services to antenatal care in low and middle income countries

Tue, 09 Feb 2016 00:00:00 +0100

Antenatal care (ANC) represents a delivery platform for a broad range of health services; however, these opportunities are insufficiently utilised. This review explores key barriers and enablers for successful integration of health s"ervices with ANC in different contexts. Data from peer‐reviewed and grey literature were organised using the SURE checklist. We identified 46 reports focusing on integration of HIV, tuberculosis, malaria, syphilis or nutrition services with ANC from Asia, Africa and the Pacific. Perspectives of service users and providers, social and political factors, and health system characteristics (such as resource availability and organisational structures) affected ease of integration. Tweetable abstractHealth system factors, context and stakeholders must be considere...



Barriers and enablers to integrating maternal and child health services to antenatal care in low and middle income countries.

Tue, 09 Feb 2016 00:00:00 +0100

Authors: de Jongh TE, Gurol-Urganci I, Allen E, Jiayue Zhu N, Atun R Abstract Antenatal care (ANC) represents a delivery platform for a broad range of health services; however, these opportunities are insufficiently utilised. This review explores key barriers and enablers for successful integration of health s"ervices with ANC in different contexts. Data from peer-reviewed and grey literature were organised using the SURE checklist. We identified 46 reports focusing on integration of HIV, tuberculosis, malaria, syphilis or nutrition services with ANC from Asia, Africa and the Pacific. Perspectives of service users and providers, social and political factors, and health system characteristics (such as resource availability and organisational structures) affected ease of integration....



Keep an Eye Out For Ocular SyphilisKeep an Eye Out For Ocular Syphilis

Mon, 08 Feb 2016 16:36:19 +0100

This devastating manifestation of syphilis infection can result in blindness if not detected and treated early. CDC Expert Commentary (Source: Medscape Today Headlines)



Diagnostic Value of Recombinant Tp0821 Protein in Serodiagnosis for Syphilis

Mon, 08 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Letters in Applied Microbiology)

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Stria vascularis and cochlear hair cell changes in syphilis: A human temporal bone study

Sat, 06 Feb 2016 00:00:00 +0100

To observe any changes in stria vascularis and cochlear hair cells in patients with syphilis. (Source: Auris, Nasus, Larynx)



Prevalence of positive HIV, HBV, HCV and treponemal tests in blood donors in a rural hospital in southern Ethiopia

Sat, 06 Feb 2016 00:00:00 +0100

Blood transfusion is common practice in tropical countries to treat endemic diseases such as malaria or chronic anemia from multiple causes. Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis represent major public health problems throughout the world. Ethiopia is among the countries where HIV and HBV infections are particularly prevalent. Screening of these blood-borne infections is crucial to prevent their transmission, and to diagnose and treat infected individuals [1]. (Source: Journal of Clinical Virology)



Comparison of serological responses to single-dose azithromycin (2 g) versus benzathine penicillin G in the treatment of early syphilis in HIV-infected patients in an area of low prevalence of macrolide-resistant Treponema pallidum infection

Fri, 05 Feb 2016 00:00:00 +0100

Conclusions In the setting of a low prevalence of macrolide-resistant T. pallidum, 2 g single-dose azithromycin achieved a similar serological response to benzathine penicillin G in HIV-infected patients with early syphilis. Major adverse effects of azithromycin were gastrointestinal symptoms and lassitude/somnolence. (Source: Journal of Antimicrobial Chemotherapy)



Survey of partner notification practices for sexually transmissible infections in the United States

Thu, 04 Feb 2016 00:00:00 +0100

Fidel A. Desir, Jessica H. Ladd, Charlotte A. Gaydos Partner notification services for chlamydia, gonorrhea, HIV, and syphilis are widely available throughout a convenience sample of testing sites in the United States. Anonymous service availability is relatively low compared to non-anonymous services. (Source: Sexual Health)



Young male sex workers are at high risk for sexually transmitted infections, a cross-sectional study from Dutch STI clinics, the Netherlands, 2006–2012

Thu, 04 Feb 2016 00:00:00 +0100

Male sex workers (MSW) are particularly exposed to sexually transmitted infections (STI) including HIV. In the Netherlands, data about STI among MSW are scarce. We estimated chlamydia, gonorrhoea, syphilis and... (Source: BMC Infectious Diseases)

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Pulmonary Consolidations Due to Secondary Syphilis with Positive Bronchial Washing Immunohistochemistry.

Wed, 03 Feb 2016 00:00:00 +0100

Authors: Jeny F, Fargelat A, Laurent-Roussel S, Nault JC, Dupin N, Grange P, Nunes H, Valeyre D PMID: 26840562 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)



Brazil Wages War against Zika Virus on Several Fronts

Tue, 02 Feb 2016 14:08:52 +0100

In the country’s capital, Brazilian President Dilma Rousseff oversees one of the military operations against the Aedes Aegypti mosquito carried out at a national level in the last few days to curb the spread of the Zika virus. Credit: Roberto Stuckert Filho/PRBy Mario OsavaRIO DE JANEIRO, Feb 2 2016 (IPS)Brazil is deploying 220,000 troops to wage war against the Zika virus, in response to the alarm caused by the birth of thousands of children with abnormally small heads. But eradicating the Aedes aegypti mosquito requires battles on many fronts, including science and the pharmaceutical industry.The Zika virus, transmitted by the Aedes aegypti mosquito, like dengue and Chikungunya fever, is blamed for the current epidemic of microcephaly, which has frightened people in Brazil and could hu...



Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection

Tue, 02 Feb 2016 13:36:02 +0100

Conclusions: Patients presented normal anterior segment and important macular and optic nerve abnormalities. Further studies will assess the visual significance of these alterations.RESUMO Introdução: No ano de 2015, foi identificado no Brasil um aumento da prevalência de microcefalia em vinte vezes. Esta malformação foi associada pelo Ministério da Saúde à transmissão vertical do Zika vírus (ZIKV). Método: Investigamos dez lactentes com diagnóstico clínico presumido de microcefalia relacionada à ZIKV, que apresentavam anormalidades oculares, nascidos entre maio e dezembro de 2015. Resultados: Sete mães (70,0%) relataram sintomas (mal-estar, rash e artralgia) durante a gestação, sendo seis (85,7%) no primeiro trimestre. No dia da avaliação nenhuma alteração ocular foi ...



A novel strategy for screening blood donors for syphilis at Komfo Anokye Teaching Hospital, Ghana

Tue, 02 Feb 2016 00:00:00 +0100

ConclusionIn other LMIC, this novel strategy can contribute to improving blood safety without jeopardising blood supply. (Source: Transfusion Medicine)



Effects of In-country and Cross-Border Mobility on Condom Use Among Transgender Women (hijras) in Bangladesh: A Cross-Sectional Study

Tue, 02 Feb 2016 00:00:00 +0100

This study concludes that in Bangladesh hijras are highly mobile and cross-border mobility negatively affects condom use. (Source: AIDS and Behavior)

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Recurrent Jarisch–Herxheimer reaction in late latent syphilis

Tue, 02 Feb 2016 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)



Cerebral Syphilitic Gumma Mimicking Glioblastoma: A Case Report

Mon, 01 Feb 2016 06:00:00 +0100

A case of suspected glioblastoma accompanied by systemic syphilis was referred to our institute for surgery. She was a 47-year-old woman presenting with headache and vomiting. A frontal mass with ring enhancement and surrounding edema was revealed by MRI. Although neurosyphilis was considered a differential diagnosis, surgery was performed and cerebral syphilitic gumma was confirmed by histology. To reduce misdiagnosis, we reviewed the related literature and summarized pathogenesis, radiologic features, and treatment strategy of cerebral syphilitic gumma. (Source: Neurosurgery Quarterly)



Efforts in blood safety: Integrated approach for serological diagnosis of syphilis

Mon, 01 Feb 2016 00:00:00 +0100

Linda Sommese, Maria Rosaria De Pascale, Maria Capuano, Claudio NapoliAsian Journal of Transfusion Science 2016 10(1):22-30Recent efforts in transfusion medicine are focused on improving blood safety as well as establishing effective and efficient diagnostic algorithms for donor screening. To date, syphilis is a transfusion-transmitted infection re-emerged in many countries as a public health threat especially among populations at specific risk. This task requires new diagnostic tools and hemovigilance programs. The current diagnostic methodologies are debated, since presenting limitations and unresolved issues with special regard to the clinical interpretation of serological patterns, especially in asymptomatic patients and in blood donors. Furthermore, the switch from the traditional to ...



Implementation of fast tests for syphilis and HIV in prenatal care in Fortaleza - Ceará.

Mon, 01 Feb 2016 00:00:00 +0100

CONCLUSION: the primary units have difficulties in implementing FT in syphilis and HIV in the prenatal routine. This activity is seen as an effective strategy to reduce vertical transmission of these infections. PMID: 26871216 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Enfermagem)



A review on ethnobotany, pharmacology and phytochemistry of Tabernaemontana corymbosa

Mon, 01 Feb 2016 00:00:00 +0100

The objective of this study is to critically evaluate the ethnobotany, medicinal uses, pharmacology and phytochemistry of the species, Tabernaemontana corymbosa (Roxb. ex Wall.) and provide information on the potential future application of alkaloids isolated from different parts of the plant. Key findingsT. corymbosa (Roxb. ex Wall.) parts are used as poultice, boiled juice, decoctions and infusions for treatment against ulceration, fracture, post‐natal recovery, syphilis, fever, tumours and orchitis in Malaysia, China, Thailand and Bangladesh. Studies recorded alkaloids as the predominant phytochemicals in addition to phenols, saponins and sterols with vast bioactivities such as antimicrobial, analgesic, anthelmintic, vasorelaxation, antiviral and cytotoxicity. SummaryAn evaluation of ...

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British Association for Sexual Health and HIV: framework for guideline development and assessment

Sun, 31 Jan 2016 00:00:00 +0100

The Clinical Effectiveness Group of the British Association for Sexual Health has updated their methodology for the production of national guidelines for the management of sexually transmitted infections and related conditions. The main changes are the adoption of the GRADE system for assessing evidence and making recommendations and the introduction of a specific Conflict of Interests policy for Clinical Effectiveness Group members and guideline authors. This new methodology has been piloted during the production of the 2015 British Association for Sexual Health & HIV guideline on the management of syphilis. (Source: International Journal of STD and AIDS)



Syphilis serology in pregnancy: an eight-year study (2005-2012) in a large teaching maternity hospital in Dublin, Ireland

Sun, 31 Jan 2016 00:00:00 +0100

All cases of positive syphilis serology detected in antenatal and peripartum screening in a large teaching maternity hospital in inner city Dublin, Ireland over an eight-year period (2005–2012 inclusive) were reviewed and included in our study. Demographic, antenatal registration, laboratory (including co-infections), partner serology, treatment and delivery data were recorded in our database. Infant follow-up, treatment and outcome data were also collected. During this period, 194 women had positive syphilis serology, of which 182 completed their pregnancies at the institution. This accounts for 0.28% of the total number of women completing their pregnancies during this time (N = 66038); 79 had no previous diagnosis of infection. There was one case of re-infection during pregnancy. ...



Well: Are You at Risk for Sexually Transmitted Infections?

Fri, 29 Jan 2016 21:04:48 +0100

A quick sex quiz from researchers at Johns Hopkins School of Medicine will give you a better idea of your chances of contracting a sexually transmitted infection. (Source: NYT)



Leeches for infections, mercury for syphilis and honey smeared on wounds: How doctors treated patients before antibiotics (and why superbugs could mean we need them again)

Fri, 29 Jan 2016 18:07:40 +0100

An expert from Texas A&M College of Medicine explained people are at risk of becoming resistant to antibiotics - and revealed pre-antimicrobial treatments society may one day have to revive. (Source: the Mail online | Health)



Laboratory Evaluation of a Dual-Path Platform Assay for Rapid Point-of-Care HIV and Syphilis Testing [Immunoassays]

Thu, 28 Jan 2016 00:00:00 +0100

We assessed the laboratory performance of the Chembio dual-path platform HIV-syphilis rapid immunodiagnostic test and electronic reader for detection of HIV and Treponema pallidum antibodies in 450 previously characterized serum specimens. For visual or electronic reader HIV antibody detection, the sensitivity was 100% and the specificity was 98.7%. For visual T. pallidum antibody detection, the test sensitivity was 94.7% and the specificity was 100.0%; with the electronic reader, the sensitivity was 94.7% and the specificity was 99.7%. (Source: Journal of Clinical Microbiology)



Primary and Secondary Syphilis

Wed, 27 Jan 2016 22:01:09 +0100

New England Journal of Medicine, Volume 374, Issue 4, Page 372-372, January 2016. (Source: New England Journal of Medicine)



Isolated anti-HBc-IgM antibody among blood donors in the semi-arid region of Nigeria.

Tue, 26 Jan 2016 04:20:04 +0100

Authors: Jeremiah ZA, Idris H, Ajayi BB, Ezimah AC, Malah MB, Baba MM Abstract Laboratory screening for the diagnosis of hepatitis B virus (HBV) infection in blood donors currently consists of testing for hepatitis B surface (HBsAg) antigen alone. The prevalence of isolated anti-HBc-IgM is not yet known in the semi arid region of Nigeria. The major objective of this study was to determine the sero-prevalence of antibody to hepatitis B core antigen (anti-HBc-IgM) and other infectious agent markers; HBsAg, HCV, HIV and Syphilis among blood donors in the North Eastern region of Nigeria. In a cross sectional study from October 2010 to January 2011, 266 blood donors were tested for the infectious disease markers using standard ELISA procedures as contained in the manufacturer's standard...



Antiphospholipid and other autoantibodies in a cohort of habitual aborters and healthy multiparous women in Jamaica.

Tue, 26 Jan 2016 04:20:04 +0100

Authors: Roye-Green K, Frederick J, Wharfe G, Choo-Kang E, DaCosta V, Fletcher H, Smikle M Abstract Blood samples from 50~women who had had recurrent spontaneous abortions and 135 healthy multiparous women were investigated for anticardiolipin (aCL) antibodies and anti-β₂ Glycoprotein 1 (anti-β₂ GP1) dependent aCL antibodies by enzyme-linked immunosorbent assays (ELISA), lupus anticoagulant activity was measured by activated partial thromboplastin time, antinuclear antibodies, rheumatoid factors and thyroid antibodies using standard techniques. Serological tests for syphilis were performed on all sera and thyroid function was evaluated. There was no significant difference in the prevalence of autoantibodies in habitual aborters and control subjects (60% and 44%, respectively)...

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Anti-inflammatory and analgesic activities of Jateorhiza macrantha (Menispermaceae)

Mon, 25 Jan 2016 00:00:00 +0100

This study was performed to evaluate the analgesic and anti-inflammatory activities of its extract.The analgesic activity of the methanolic extract of Jateorhiza macrantha was investigated using the acetic acid (chemical) and tail-clip (mechanical) models of nociception in mice and the anti-inflammatory activity was investigated using the carrageenan-induced paw oedema in rats.  In acetic acid-induced writhing test, the extract at doses 100, 200 and 400 mg/kg significantly (P < 0.05, 0.01) reduced the writhing reflex in a dose dependent manner. In the application of the metal artery clip unto the tail of animals, the extract caused a significant (P < 0.05) dose dependent increase in reaction latency with peak effect (7.0%) inhibition produced at the highest dose of 400 mg/kg. In the...



Sexually transmitted infections and pre-exposure prophylaxis: challenges and opportunities among men who have sex with men in the US.

Sun, 24 Jan 2016 17:52:02 +0100

Authors: Scott HM, Klausner JD Abstract Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in "real world" reports of clinical implementation and a PrEP demonstration project. Those studies also demonstrated high bacterial sexually transmitted infection (STI) incidence and raised the discussion of how PrEP may impact STI control efforts, especially in the setting of increasing Neisseria gonorrhoeae antimicrobial resistance and the increase in syphilis cases among MSM. Here, we discuss STIs as a driver of HIV transmission risk among MSM, and the potential opportunities and challenges for STI control afforded by expanded PrEP implem...



Stillbirths: rates, risk factors, and acceleration towards 2030

Sat, 23 Jan 2016 00:00:00 +0100

Publication date: Available online 19 January 2016 Source:The Lancet Author(s): Joy E Lawn, Hannah Blencowe, Peter Waiswa, Agbessi Amouzou, Colin Mathers, Dan Hogan, Vicki Flenady, J Frederik Frøen, Zeshan U Qureshi, Claire Calderwood, Suhail Shiekh, Fiorella Bianchi Jassir, Danzhen You, Elizabeth M McClure, Matthews Mathai, Simon Cousens An estimated 2·6 million third trimester stillbirths occurred in 2015 (uncertainty range 2·4–3·0 million). The number of stillbirths has reduced more slowly than has maternal mortality or mortality in children younger than 5 years, which were explicitly targeted in the Millennium Development Goals. The Every Newborn Action Plan has the target of 12 or fewer stillbirths per 1000 births in every country by 2030. 94 mainly high-income...



A case of syphilitic aortic aneurysm with sternal erosion and impending rupture

Thu, 21 Jan 2016 00:00:00 +0100

We report a case of syphilitic aortic aneurysm eroding through the sternum in a 52-year-old man who underwent successful surgical repair. (Source: Asian Cardiovascular and Thoracic Annals)



A new enhanced antibiotic treatment for early and late syphilis

Thu, 21 Jan 2016 00:00:00 +0100

In conclusion, the enhanced treatment is more effective than standard treatment and results in a higher and faster cure rate. Moreover, it provides treponemicidal antibiotic levels in the cerebrospinal fluid, thereby preventing possible late complications. (Source: Journal of Global Antimicrobial Resistance)

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Real-time PCR using the 529 bp repeat element for the diagnosis of atypical ocular toxoplasmosis

Thu, 21 Jan 2016 00:00:00 +0100

Conclusions The novel real-time PCR assay described is more sensitive than those targeting the Toxoplasma B1 gene owing to the higher number of repeats and highly conserved sequence level. This technique can be applied in clinical practice and provides a valuable tool for the rapid diagnosis of ocular toxoplasmosis. (Source: British Journal of Ophthalmology)