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MedWorm: HIV/AIDS



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the HIV/AIDS category.



Last Build Date: Tue, 29 Mar 2016 16:31:58 +0100

 



The challenge of opportunistic infections: Focus on South America

Tue, 29 Mar 2016 09:23:41 +0100

Abstract: Some opportunistic diseases are either exclusive or more commonly observed in South American AIDS patients than in those from different parts of the world. Interactions between HIV and endemic parasitic and other locally prevalent pathogens occur frequently in South America. However, knowledge about the impact of these interactions has been accumulating only recently. (Source: International Journal of Infectious Diseases)

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Challenges in the management of opportunistic infections: Focus on Southeast Asia

Tue, 29 Mar 2016 09:23:41 +0100

Abstract: Late presenters into HIV care remain common in South East Asia. In an analysis of more than 3700 patients in an Asian observational cohort, more than 72% were late presenters ie presenting into HIV care for the first time with CD4 of < 200 cells/mm3 or with an AIDS defining illness. Consequently physicians in South East Asia continue to manage patients who present with a myriad of opportunistic infections including toxoplasmosis, CMV infection, disseminated fungal infections and tuberculosis. (Source: International Journal of Infectious Diseases)



The long-term impact of antiretroviral therapy in resource-limited settings

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: With the advent of antiretroviral therapy (ART), HIV has shifted to a chronic manageable condition, even in resource-limited settings. Now, the long-term effects of being on ART and living with HIV are emerging. These include the adverse effects of long-term ART and morbidity due to non AIDS complications such as cardiovascular, hepatic, renal, metabolic and neurocognitive disease, cancers and ageing as well as complications due to hepatitis B and C co-infection. Although first and second-line antiretrovirals are available in resource-limited settings, new antiretrovirals are urgently needed in order to sustain HIV as a chronic manageable condition. (Source: International Journal of Infectious Diseases)



Egypt experience in treating HCV

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: Infection with HIV and HCV contributes substantially to the global burden of disease, with an estimated 4-5 million people living with both infections. The natural history of HIV and HCV is significantly impacted by the coexistence of the other virus. Increases in all-cause, AIDS-related, and liver-related morbidity, hospitalization, and mortality are noted, with accelerated liver disease progression and high rates of end-stage liver disease, even in those receiving combination antiretroviral therapy (cART) Given greater access to cART, the number of global deaths related to HIV is falling. (Source: International Journal of Infectious Diseases)



India - National disaster and epidemic preparedness

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: History provides us several illustrations where epidemic outbreaks have led to biological disasters. Accidental or deliberate release of harmful micro-organisms can also lead to biological disasters. With the advent of bio-terrorism, there is a growing realisation that biological agents can also be used as weapons of mass destruction. The spread of Spanish Influenza of 1917-18, the Human Immunodeficiency Virus (HIV) / Acquired Immuno Deficiency Syndrome (AIDS), Severe Acute Respiratory Syndrome (SARS), Swine Flu (H1N1), Avian Influenza (H5N1), Middle East Respiratory Syndrome (MERS), dengue, chikunguniya, Ebola outbreak in West Africa and the recent Zika outbreak in several countries tested the capacities of the public health delivery system in several countries. (Source: Interna...



Attitude toward quoting research evidence in technical guidelines on the Nigeria HIV/AIDS program

Tue, 29 Mar 2016 09:23:39 +0100

Background: In 2013 Nigeria was home to 9% of PLHIV, 10% of new infections and 14% of AIDS related deaths. HIV programs are directed by relevant evidence based National guidelines; providers in Nigeria have however continued to use various guidelines for patient management, stating the availability of evidence based research from various sources in other guidelines. (Source: International Journal of Infectious Diseases)

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Adherence to antiretroviral drug treatment ARV among people living with HIV/AIDS: A study from Eastern Nepal

Tue, 29 Mar 2016 09:23:39 +0100

This study aimed to determine adherence to ART and identify associated factors with adherence among people with HIV/AIDS and receiving ART/ARV therapy. (Source: International Journal of Infectious Diseases)



APAIDSON program evaluation of the largest private public partnership consortium for HIV/AIDS care and treatment in India

Tue, 29 Mar 2016 09:23:38 +0100

Background: In India, private institutions were not involved in the activities of National AIDS Control Program (NACP). Andhra Pradesh AIDS Consortium (APAIDSCON) the largest public health partnership a network of 20 medical colleges established to address HIV AIDS in India was spearheaded by SHARE India and funded in part by United States Centers for Disease Control & Prevention Cooperative agreement # U62/CCU025160-02. 2005 –2010. A program evaluation based on CDC Project Evaluation protocols was undertaken in 2013-14 to evaluate APAIDSCON results. (Source: International Journal of Infectious Diseases)



Cryptococcus meningitis and the genotypes of cryptococcus neoformans prevalent in Western Maharashtra, India

Tue, 29 Mar 2016 09:23:37 +0100

Background: Cryptococcal meningitis is an AIDs defining illness. However the disease is seen in patients without HIV infection also. Attempts have been made to develop a vaccine for the disease, so the prevalent genotypes of Cryptococcal neoformans need to be identified. In the Indian scenario there is a paucity of literature on MLST genotyping. Genotyping of C. neoformans can be performed for epidemiological purpose, to determine whether the cryptococcosis is caused by single genotype or two or more genotypes and to develop vaccine production. (Source: International Journal of Infectious Diseases)



Health related quality of life of HIV/AIDS patients on highly active antiretroviral therapy in Ahmadu Bello University Teaching Hospital

Tue, 29 Mar 2016 09:23:37 +0100

This study aims to determine the health related quality of life of HIV/AIDS patients on HAART at Ahmadu Bello University Teaching Hospital (ABUTH) Zaria. (Source: International Journal of Infectious Diseases)



Effectiveness of AIDS education program on nursing students’ knowledge and attitudes in Sri Lanka

Tue, 29 Mar 2016 09:23:37 +0100

Background: Stigmatization and discrimination of HIV/AIDS patients is an important issue in health care institutions. Nurses, who play a key role in health care of people living with HIV (PLHIV), should be professionally competent in AIDS knowledge and AIDS attitudes. This is necessary to minimise the stigmatization and discrimination towards PLHIV and to protect patients’ dignity. In Sri Lanka, like in many other countries, nurses’ AIDS knowledge and attitudes are not satisfactory. Various interventions used to correct this in many countries had in-consistent results. (Source: International Journal of Infectious Diseases)

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HIV-mediated CD8 encephalitis: An under recognised entity

Tue, 29 Mar 2016 09:23:37 +0100

Background: Combined antiretroviral therapy (cART) has been associated with significant decrease in the mortality and morbidity in patients with HIV/AIDS. However, there has been increased recognition of immune dysregulation syndromes related to recovery of immunity on cART. HIV-mediated CD8 encephalitis is a rare neurological syndrome due to perivascular inflammation caused by infiltration of CD8+ cells. (Source: International Journal of Infectious Diseases)



Caregiver burden among adults caring for people living with HIV/AIDS (PLWHA) in South India

Tue, 29 Mar 2016 09:23:37 +0100

Background: Caregiver burden refers to the physical, emotional and financial hardships associated with caregiving for an ailing individual. Attending to the needs of people living with HIV/AIDS (PLWHA) can place a significant burden on family members. This may adversely affecting their quality of life (QOL). The main aim of our study was to assess the caregiver burden and QOL among family members of PLWHA in South India. We also tried to determine the impact of caregiver burden on QOL. (Source: International Journal of Infectious Diseases)



Retrospective analyses of CD4 count monitoring to detect ART response

Tue, 29 Mar 2016 09:23:37 +0100

Background: National AIDS Control Programme was launched in 1992 by National AIDS Control Organization for prevention and control of HIV/AIDS in India. Viral load testing is a preferred test to monitor treatment response of antiretroviral therapy (ART). However, for more than two decades, CD4 cell count measurements have been used as a major marker in understanding HIV disease progression, making important clinical decisions, and monitoring the response to ART. In India, most of the laboratories have been using CD4 count for monitoring the response of ART. (Source: International Journal of Infectious Diseases)



The characteristics of HIV/AIDS patients with deep vein thrombosis at Dr George Mukhari Academic Hospital

Tue, 29 Mar 2016 09:23:37 +0100

Background: Deep vein thrombosis (DVT) is ten times more prevalent in HIV/AIDS patients than the general population. HIV/AIDS has also been shown to be a hypercoagulable state which is worsened by conditions like malignancies, opportunistic infections, some auto-immune diseases and chemotherapeutic agents. (Source: International Journal of Infectious Diseases)



Knowledge and practice of the prevention of mother-to-child transmission of HIV guidelines among doctors and nurses at Tswane District, South Africa

Tue, 29 Mar 2016 09:23:37 +0100

Background: Since the beginning of the HIV/AIDS epidemic, almost 60 million people have been infected and 25 million people have already died from HIV related causes, (WHO, 2010). Sub Saharan Africa is the region most affected with 67% of all people living with HIV worldwide and 91% of all new infections among children. In South Africa, the mother-to-child HIV transmission (MTCT) rate is under 4% at 4 to 8 weeks after birth since the implementation of the most recent national PMTCT programme. The PMTCT programme in South Africa has gained rapid momentum in training and practice. (Source: International Journal of Infectious Diseases)

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Secondary data analysis of HIV/AIDS control programme data, Enugu State (2010-2013)

Tue, 29 Mar 2016 09:23:37 +0100

Background: As of 2012, 3,400000 million people (all ages) are living with HIV in Nigeria. The estimated new HIV infections is 260,000 and estimated AIDS death is 240,000. The reported number of adults on ART(Anti-retroviral treatment) was 459,465 and the ART coverage based on WHO guideline was 36%. The number of pregnant women living with HIV who received antiretroviral for preventing mother- to-child –transmission was 33,323 and the percentage coverage was 17%1. Enugu State has the highest prevalence(6.5%) of HIV/ AIDS in the South East and the fourth in Nigeria. (Source: International Journal of Infectious Diseases)



HLA-C*07 allele group confers protection against cytomegalovirus retinitis development among Brazilian AIDS patients

Tue, 29 Mar 2016 09:23:37 +0100

Background: Even though antiretroviral therapy has reduced the incidence of cytomegalovirus retinitis (R-CMV), this disorder continues to be a considerable cause of visual impairment among AIDS patients. The incidence of R-CMV is increasing in young patients outside the first world who, despite the control of HIV-1 viremia, are blind, either because retinitis has not been diagnosed or has incorrectly been treated. An insertion/deletion fragment at the 3’untranslated region of the HLA-C gene has been associated with progression to AIDS after HIV infection. (Source: International Journal of Infectious Diseases)



Ecological study of HIV cases with socio-crime factors associated in Indonesia

Tue, 29 Mar 2016 09:23:37 +0100

Background: Previous publication presented in International AIDS Conference in Vienna, 2010, shows that women who experience domestic violence have potential risk of contracting HIV at least two times greater. WTO report in 2013 also support the fact that in some regions, women who are victims of domestic violence are 1.5 times more likely to contract HIV than those who do not have experienced violence with their intimate partner. Corruption is considered factors if there is misappropriation funds that hampering the HIV prevention program in the country. (Source: International Journal of Infectious Diseases)



Development of engineered nanocarrier for controlled delivery of a protease inhibitor

Tue, 29 Mar 2016 09:23:37 +0100

Background: AIDS is a chronic, progressive syndrome, characterized by intense viral replication and profound immunosuppression, resulting in the development of life threatening opportunistic infections. HIV infection leads to deterioration of immune functions. (Source: International Journal of Infectious Diseases)



Insilico analysis of micro RNA based target interaction associated with pharmacogenomics of acquired immune deficiency syndrome

Tue, 29 Mar 2016 09:23:37 +0100

Background: Analysis of micro RNA(miRNAs) based regulatory networks in infectious diseases is a challenging task in the era of post genomics and prediction of the miRNAs associated with pharmacogenomics of acquired Immune Deficiency Syndrome (AIDS) is an initiation towards the miRNA based therapy for AIDS. (Source: International Journal of Infectious Diseases)

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Private public partnership for stigma free HIV service delivery in APAIDSCON network in India

Tue, 29 Mar 2016 09:23:37 +0100

Background: Andhra Pradesh state has the highest HIV burden in India. Andhra Pradesh AIDS Consortium (APAIDSCON) the largest public health partnership a network of 20 medical colleges established to address HIV AIDS in India was spearheaded by SHARE India and funded in part by United States Centers for Disease Control & Prevention Cooperative agreement # U62/CCU025160-02. 2005 –2010 (Source: International Journal of Infectious Diseases)



Isospora belli associated recurrent diarrhea in a patient with AIDS

Tue, 29 Mar 2016 09:23:36 +0100

Background: Recurrent diarrhea is a major complication of Acquired Immunodeficiency Syndrome (AIDS) or Human Immunodeficiency Virus (HIV) infected cases. Isospora belli causes diarrhoea in patients with AIDS. The prevalence of isosporiasis is probably underestimated in developing countries because routinely not all HIV-infected people are examined for the presence of this protozoan infection. (Source: International Journal of Infectious Diseases)



Prevalence and predictors of tuberculosis among adults with newly diagnosed HIV/AIDS

Tue, 29 Mar 2016 09:23:35 +0100

Background: Tuberculosis and HIV co-infection not only presents a challenge in diagnosis and therapy but also constitutes a high burden on healthcare systems. A survey was designed to study the prevalence of and risk factors for tuberculosis among antiretroviral-naive HIV-infected adults. (Source: International Journal of Infectious Diseases)



Angola: Health Authorities Sensitize People Against HIV/Aids

Tue, 29 Mar 2016 08:58:32 +0100

[ANGOP] Kuito -The health authorities of the municipality of Cuemba, 164 kilometers east off Kuito city, central Bie province, continue to sensitize people against HIV / AIDS in schools, parks and other places of the highest population in order to combat the disease within families. (Source: AllAfrica News: HIV-Aids and STDs)



Safety of HIV PrEP in Individuals With Active Hepatitis BSafety of HIV PrEP in Individuals With Active Hepatitis B

Tue, 29 Mar 2016 08:26:22 +0100

Is HIV pre-exposure prophylaxis safe for individuals with HBV infection? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Hiv-Aids Headlines)

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Quantitative ultrasound CAD analyzes multiple conditions

Tue, 29 Mar 2016 07:00:00 +0100

Researchers have created an algorithm for computer-aided detection (CAD) of...Read more on AuntMinnie.comRelated Reading: Ultrasound CAD aids in characterizing breast lesions Interactive US CAD aids in characterizing breast lesions US CAD boosts differentiation of focal liver lesions (Source: AuntMinnie.com Headlines)



Malawi: Saving Children's Lives Through Drones

Tue, 29 Mar 2016 06:45:02 +0100

[IPS] Lilongwe, Malawi -The first successful test-flight of an unmanned aerial vehicle (UAV) or drone was an unhindered 10 km journey from a community health centre to the Kamuzu central hospital laboratory in the capital Lilongwe. Local community members watched with excitement as the drone rose into the sky, after being launched by the United Nations Children's Emergency Fund (UNICEF) and government of Malawi at the area 25 health centre. (Source: AllAfrica News: HIV-Aids and STDs)



A systematic review of decision aids for patients making a decision about treatment for early breast cancer.

Mon, 28 Mar 2016 21:23:02 +0100

Authors: Nicholas Zdenkowski, Butow P, Tesson S, Boyle F Abstract Several complex treatment decisions may be offered to women with early stage breast cancer, about a range of treatments from different modalities including surgery, radiotherapy, and endocrine and chemotherapy. Decision aids can facilitate shared decision-making and improve decision-related outcomes. We aimed to systematically identify, describe and appraise the literature on treatment decision aids for women with early breast cancer, synthesise the data and identify breast cancer decisions that lack a decision aid. A prospectively developed search strategy was applied to MEDLINE, the Cochrane databases, EMBASE, PsycINFO, Web of Science and abstract databases from major conferences. Data were extracted into a pre-pil...



Smart Fit Tips for Entrepreneurs Who Want to Stay Healthy On the Road

Mon, 28 Mar 2016 21:08:59 +0100

Conclusion -- It's Never Ideal If you are an expert in travel, the chances are you have already managed to get yourself into a routine for working out on the road. But what you should understand is that a life of constant travel is never ideal for keeping yourself in perfect shape. The workouts you perform on the road are designed to maintain your current level of fitness. They are not designed for pushing boundaries. Don't get upset if the local gym doesn't have a squat rack. Be prepared to compromise and use what's there. You'll soon get into a rhythm and you'll soon find out what works for you. After all, you only have to survive a few days with fitness on the road before you're back home again. -- This feed and its contents are the property of The Huffington Post, and use is subject to...



Vietnam’s Battle With Tuberculosis

Mon, 28 Mar 2016 20:29:59 +0100

A country’s stunning progress against tuberculosis may be threatened by reduced support for a health care system stretched thin. (Source: NYT Health)

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An Open Letter to the Boston Globe About Lyme Disease

Mon, 28 Mar 2016 19:45:00 +0100

Today, the Boston Globe editorial board spoke out against a bill "that would require insurers in Massachusetts to cover Lyme disease treatments for as long as a doctor says they're needed." The Globe writes: Lawmakers may have good intentions, but they don't possess the expertise to decide whether it's beneficial, cost-efficient, or safe, to keep using strong medicines to treat a condition the medical establishment doubts is real. Such questions should be resolved by a consensus of doctors and researchers -- and buttressed by convincing clinical date [sic] -- not determined by legislative mandate. Who among the Boston Globe editorial board possesses the medical expertise to make this call is not disclosed, but this information would be useful given that the Globe's stance presumes absolute...



Urine-Based Assay Cuts Mortality in African Trial of HIV-TBUrine-Based Assay Cuts Mortality in African Trial of HIV-TB

Mon, 28 Mar 2016 19:39:01 +0100

A commercially available urine-based assay reduced eight-week mortality among inpatients with HIV and suspected tuberculosis (TB) in a randomized clinical trial involving 10 hospitals in Africa. Reuters Health Information (Source: Medscape Hiv-Aids Headlines)



Mp38-20 simplified clinical comorbidity index for patients candidate to radical cystectomy

Mon, 28 Mar 2016 19:24:11 +0100

Several variables used in the definition of the Charlson comorbidity index (CCI) may not be applicable in contemporary patients candidate to radical cystectomy-RC- (i.e. severe liver disease, dementia, hemiplegia or paraplegia, AIDS) and others may have limited discriminant abilities. We attempted to identify the most informative predictors of perioperative mortality, in RC candidates, within the 17 original groupings of comorbid conditions that are used to quantify the Deyo implementation of CCI. (Source: The Journal of Urology)



Mp63-01 a proposal for a novel peri-operative mortality risk assessment tool in contemporary patients treated with radical cystectomy

Mon, 28 Mar 2016 19:24:08 +0100

The Charlson comorbidity index (CCI) is the most widely used index score in retrospective analyses. However, several comorbid conditions included in this index, such as sever liver disease, AIDS, leukemia/lymphoma, are never seen in patients candidate to radical cystectomy (RC). Some other comorbid conditions, such as diabetes, and chronic pulmonary disease, are very frequently seen. Conversely, other conditions that are not accounted within that CCI index may represent better predictors of perioperative mortality. (Source: The Journal of Urology)



Pd17-10 assigning value to the personal patient profile-prostate decision aid: a willingness to pay analysis

Mon, 28 Mar 2016 19:24:07 +0100

The objective of this analysis was to estimate patients' WTP for the Personal Patient Profile-Prostate (P3P), a Web-based decision support system that has been shown to decrease decisional conflict in men newly diagnosed with localized prostate cancer. (Source: The Journal of Urology)

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Mp37-17 clinical use of patient decision-making aids for management decisions in stone patients: a shared decision making approach

Mon, 28 Mar 2016 19:24:05 +0100

The dynamics of the patient-physician relationship has evolved in recent years with an increased emphasis on patient education and involvement in shared decision-making (SDM). Patient decision making aids (PDMAs) have been shown to help patients make more informed decisions regarding their care and improve patient satisfaction. We evaluated the utility and applicability of PDMAs developed at our stone center and used it in the outpatient clinical setting in patients considering treatment options for urolithiasis. (Source: The Journal of Urology)



Mp76-06 use and effectiveness of pharmacologic and non-pharmacologic erectile aids among post-prostatectomy prostate cancer survivors seeking treatment for erectile dysfunction: a prospective, multicenter study

Mon, 28 Mar 2016 19:24:04 +0100

Erectile dysfunction (ED) is the most common health-related quality of life complaint following prostate cancer (CaP) treatment. We assessed use and effectiveness of various pharmacologic and non-pharmacologic erectile function aids following radical prostatectomy (RP). (Source: The Journal of Urology)



Mp82-08 health related quality of life in patients with urolithiasis – qualitative research to aid development of patient reported measures and decision aids

Mon, 28 Mar 2016 19:24:03 +0100

Urolithiasis is a common, recurrent disease and can heterogeneous in nature. Management involves medical and surgical interventions, with significant impact on patients' health-related quality of life (HRQoL). (Source: The Journal of Urology)



Enzyme may reduce risk of cardiovascular disease caused by HIV medications

Mon, 28 Mar 2016 16:02:54 +0100

Approximately 37 million people are living with HIV. Antiviral medications are used to control the disease and prevent its progression to AIDS. Although antivirals improve health and increase survival for people with HIV, their use also has been linked to the development of cardiovascular disease. Now, researchers have identified an enzyme that may reduce the risk of cardiovascular disease caused by HIV medications. (Source: ScienceDaily Headlines)



Liver Fibrosis Marker as a Predictor of Mortality in HIV/HCVLiver Fibrosis Marker as a Predictor of Mortality in HIV/HCV

Mon, 28 Mar 2016 15:39:15 +0100

Do enhanced liver fibrosis measurements accurately predict mortality in HIV/HCV infected women? AIDS (Source: Medscape Today Headlines)

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Malawi: Ta M'bang'ombe Community Requests More HIV/Aids Interventions

Mon, 28 Mar 2016 10:49:20 +0100

[Malawi News Agency] Lilongwe -Communities in the area of Traditional Authority M'bang'ombe in Lilongwe have requested service providers in the district to make available more HIV interventions. (Source: AllAfrica News: HIV-Aids and STDs)



Malawi: Male Unfriendly Health Services Fuelling Spread of HIV - NAC

Mon, 28 Mar 2016 10:46:16 +0100

[Malawi News Agency] Lilongwe -A study by National AIDS Commission (NAC) has revealed that male unfriendly health services are reducing male participation in HIV related activities and fuelling the spread of HIV. (Source: AllAfrica News: HIV-Aids and STDs)



Saving Children’s Lives Through Drones

Mon, 28 Mar 2016 09:59:40 +0100

The drone took 10 minutes to cover 10 km. Photo Credit: UNICEFBy Charity Chimungu PhiriLILONGWE, Malawi, Mar 28 2016 (IPS)The first successful test-flight of an unmanned aerial vehicle (UAV) or drone was an unhindered 10 km journey from a community health centre to the Kamuzu central hospital laboratory in the capital Lilongwe. Local community members watched with excitement as the drone rose into the sky, after being launched by the United Nations Children’s Emergency Fund (UNICEF) and government of Malawi at the area 25 health centre. The first of its kind in southern Africa, the US manufactured machine was on trial till March 18 to determine if it could replace other modes of transporting dried blood samples from rural clinics to the main laboratories for early HIV screening in childr...



Zimbabwe: Door-to-Door HIV Testing Gathers Momentum

Mon, 28 Mar 2016 08:31:21 +0100

[The Herald] THE Biomedical Research and Training Institute says it has tested nearly half of the 30 000 people it targeted for its ground-breaking door-to-door HIV testing. The HIV survey started in October last year. Addressing stakeholders attending the Matabeleland South provincial launch of the Zimbabwe Population based HIV Impact Assessment (Zimphia) in Gwanda last week, Dr Shungu Munyati said 14 050 people have so far been tested from selected households in five districts of the country. Dr Munyati said the majo (Source: AllAfrica News: HIV-Aids and STDs)



Kenya: Study - 500,000 Not Aware They Have HIV

Mon, 28 Mar 2016 07:27:03 +0100

[Nation] For every three Kenyans who test positive for HIV, one new case is diagnosed through their referral, a study has shown. (Source: AllAfrica News: HIV-Aids and STDs)

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Enzyme may reduce risk of cardiovascular disease caused by HIV medications

Mon, 28 Mar 2016 04:00:00 +0100

(University of Missouri-Columbia) According to the World Health Organization, approximately 37 million people are living with HIV. Antiviral medications are used to control the disease and prevent its progression to AIDS. Although antivirals improve health and increase survival for people with HIV, their use also has been linked to the development of cardiovascular disease. Now, researchers at the University of Missouri School of Medicine have identified an enzyme that may reduce the risk of cardiovascular disease caused by HIV medications. (Source: EurekAlert! - Medicine and Health)



Cerebrospinal Biomarkers in Alzheimer Disease

Mon, 28 Mar 2016 00:00:00 +0100

Biomarkers as aids to diagnosis, prognosis, and effective therapies have become holy grails of translational neuroscience. In neurodegenerative disorders, especially Alzheimer disease (AD), imaging and cerebrospinal fluid (CSF) biomarkers for the amyloid-β (Aβ) protein and tau have found their place in research and clinical trials, enabling much more accurate diagnosis. Despite these advances in diagnostic biomarkers, less progress has been made with respect to biomarkers of progression. Alzheimer disease progresses slowly and has a long preclinical stage prior to clinical manifestations; biomarkers of progression could provide invaluable information to assess the efficacy of potential disease-modifying agents in clinical trials. If medicines modify disease progression by slowing neurode...



Analysis of Driving Factors of Willingness to Use and Willingness to Pay for Existing Pharmacological Smoking Cessation Aids Among Young and Middle-Aged Adults in Germany

Sun, 27 Mar 2016 22:00:00 +0100

Conclusion This study indicates different points to be considered for policy development. Promotion information and improving awareness about medication aids might increase WTU, and development of monetary incentives for young smokers could create a better chance for successful smoking cessation. (Source: Applied Health Economics and Health Policy)



Synergistic effect of spices in a decoction regulates the energy metabolism in liver cancer cells

Sun, 27 Mar 2016 22:00:00 +0100

The objective of the study was to determine the synergistic effect of spices in a decoction; Turmeric (Curcuma longa), Pepper (Piper nigrum) and Garlic (Allium sativum) in combination, on the metabolism of Hep G2 liver cancer cells.The biochemical studies of 2 major enzymes involved in cellular metabolism of cells namely; Pyruvate dehydrogenase (PDH) and Lactate dehydrogenase A (LDHA) showed that the decoction down regulated the activity of LDHA and increased the activity of PDH in cancer cells, thereby shifting the metabolic mechanism towards normal functioning in the cancer cells. The expression studies of major molecules involved in regulating metabolic machinery in cells viz., tumour suppressor p53 and oncogene MYC mRNAs; and western blot analysis of Hypoxia inducible factor-1-alpha (H...



Psychosocial impact of visual impairment and coping strategies in female ex-Service personnel

Sun, 27 Mar 2016 22:00:00 +0100

Conclusions Sustaining a visual impairment negatively affects psychosocial well-being in female ex-Service personnel. Over time, participants learnt to cope with the challenges and limitations associated with being visually impaired. (Source: Journal of the Royal Army Medical Corps)

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Acceptability of Couples' Voluntary HIV Testing Among HIV-infected Patients in Care and Their HIV-negative Partners in the United States.

Sun, 27 Mar 2016 06:51:03 +0100

CONCLUSION: These results indicate that CHTC for serodiscordant couples is acceptable and should emphasize aspects most pertinent to these couples, such as discussion of ART/PrEP, STIs, and relationship agreements. PMID: 27014393 [PubMed] (Source: Open AIDS Journal)



Dual language versus English-only support for bilingual children with hearing loss who use cochlear implants and hearing aids.

Sat, 26 Mar 2016 23:00:00 +0100

CONCLUSIONS & IMPLICATIONS: In addition to providing support in English, encouraging home language use and providing treatment support in the first language may help rather than hinder development of both English and the home language in bilingual children with HL who use CIs and HAs. In fact, dual-language support may yield better overall and expressive English language outcomes than English-only support for this population. PMID: 27017913 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)



Orbit Refreshable Braille Reader

Sat, 26 Mar 2016 19:25:02 +0100

The Orbit braille reader is the first ever affordable refreshable braille reader that is also portable (Source: Disabled World)



Psychological correlates of suicidality in HIV/AIDS in semi-urban south-western Uganda - Rukundo GZ, Mishara B, Kinyanda E.

Sat, 26 Mar 2016 11:13:34 +0100

There is a paucity of data on the prevalence of suicidality in HIV/AIDS, and associated psychological factors in sub-Saharan Africa, shown to be high in Uganda. Yet, the region accounts for over 70% of the world HIV burden. Our study used a cross-sectional... (Source: SafetyLit)



Opportunistic Pulmonary Infections in Immunocompromised Hosts

Sat, 26 Mar 2016 07:44:23 +0100

Infections that are typically innocuous in immunocompetent persons may cause significant disease states in immunocompromised hosts. These individuals may be immunosuppressed secondary to many different causes such as drugs, malignancy, solid-organ or hematopoietic stem cell transplantation, HIV/AIDS, or anatomic reasons (asplenia). These immunocompromised hosts are at high risk for developing opportunistic infections. Here, we discuss some of these infections caused by bacteria, fungi, viruses, and parasites. Clinicians should be aware of the risk factors, common clinical presentations, diagnostic modalities, and treatment options for these potentially fatal illnesses. (Source: Critical Care Nursing Quarterly)

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Reduced Levels of Genital Tract Immune Biomarkers in Postmenopausal Women: Implications for HIV Acquisition

Fri, 25 Mar 2016 23:00:00 +0100

Rates of HIV infections are increasing in older adults. Although it is known that the HIV/AIDS epidemics affects women disproportionately, little is known regarding immune functions in the genital tract of postmenopausal women, as relevant to HIV susceptibility. (Source: American Journal of Obstetrics and Gynecology)



What Can The Evolution Of Our Sleep Habits Teach Us?

Fri, 25 Mar 2016 21:20:52 +0100

When Amy Ozski started experiencing insomnia last August, it wasn't due to anything drastic. She recalls a heat wave in the Boston area where she lives, a bit more stress at work, and her schedule being thrown off for a few consecutive days. But the combination was enough to trigger a pattern: Ozski started having trouble falling asleep, and before long the problem snowballed into a chronic issue. Sometimes it would take her hours to fall asleep, or she'd wake up in the middle of the night and struggle to conk out again. Sleep -- and the lack of it -- took over her life. "It was all I thought about during the day," she says. "I was miserable." Ozski tried everything she could think of to fix the problem, from transcendental meditation to acupuncture, but to no avail. Finally, she sought he...



How People of Faith Can Help End TB

Fri, 25 Mar 2016 21:14:08 +0100

(function(){var src_url="https://spshared.5min.com/Scripts/PlayerSeed?playList=519608076&height=&width=100&sid=577&origin=undefined&videoGroupID=155847&relatedNumOfResults=100&responsive=true&ratio=wide&align=center&relatedMode=2&relatedBottomHeight=60&companionPos=&hasCompanion=false&autoStart=false&colorPallet=%23FFEB00&videoControlDisplayColor=%23191919&shuffle=0&isAP=1&pgType=cmsPlugin&pgTypeId=grabCodeLightbox&onVideoDataLoaded=HPTrack.Vid.DL&onTimeUpdate=HPTrack.Vid.TC";if (typeof(commercial_video) == "object") {src_url += "&siteSection="+commercial_video.site_and_category;if (commercial_video.package) {src_url += "&sponsorship="+commercial_video.package;}}var script = document.createElement("script");script.src = src_url;script.async = true;var placeholder = docum...



Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Majewski M, Kozlowska A, Thoene M, Lepiarczyk E, Grzegorzewski WJ Abstract The kynurenine pathway (KP) of L-tryptophan metabolism produces several neuroactive metabolites with an amino acid structure. These metabolites may play an important role in the pathophysiology of irritable bowel syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, schizophrenia, AIDS-dementia complex, depression, epilepsy and the aging process. Modulation of the KP through inhibition or stimulation of enzyme synthesis and activity can be an alternative approach to traditional therapy. Furthermore, it may be responsible for the altered functioning of the enteric nervous system and the central nervous system. There is evidence that the KP is sensitive to changes in the concentrat...



HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample.

Fri, 25 Mar 2016 18:53:03 +0100

Conclusions. The prevalence of HIV-OMH in the study population was 18.5%, the gingiva being the most commonly affected site. It appears that the CD4+ T cell count does not play any role in the biopathology of HIV-OMH. PMID: 27006825 [PubMed] (Source: AIDS Research and Treatment)



HIV/AIDS Community Information Outreach Projects 2016

Fri, 25 Mar 2016 16:52:08 +0100

The National Library of Medicine (NLM) is pleased to announce the solicitation of quotations from organizations and libraries to design and conduct projects for improving HIV/AIDS information access for patients and the affected community as well as their caregivers and the general public. Patients and the affected community need access to the most up-to-date and […] (Source: NN/LM Middle Atlantic Region Blog)



Renal abnormalities in a cohort of HIV-infected children and adolescents

Fri, 25 Mar 2016 16:22:21 +0100

Conclusions The subclinical renal abnormalities found in this study may indicate early manifestations of a broad spectrum of renal dysfunction associated with HIV and involves the decision to initiate or modify ART. (Source: Pediatric Nephrology)

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Home-based rehabilitation interventions for adults living with HIV: a scoping review.

Fri, 25 Mar 2016 15:52:07 +0100

Authors: Cobbing S, Hanass-Hancock J, Myezwa H Abstract Home-based rehabilitation (HBR) has been shown to improve the lives of people living with a wide range of chronic diseases in resource-rich settings. This may also be a particularly effective strategy in resource-poor settings, where access to institution-based rehabilitation is limited. This review aimed to summarise and discuss the evidence related to the effectiveness of home-based rehabilitation (HBR) interventions designed specifically for adults living with HIV. A scoping review methodology was employed, involving systematic search techniques and appraisal of appropriate evidence. English-language journal articles that assessed the quality of life or functional ability outcomes of HBR interventions for adults living with...



New insights into HIV epidemic in South Africa: key findings from the National HIV Prevalence, Incidence and Behaviour Survey, 2012.

Fri, 25 Mar 2016 15:52:07 +0100

This article presents key findings from the 2012 HIV prevalence, incidence and behaviour survey conducted in South Africa and explores trends in the HIV epidemic. A representative household based survey collected behavioural and biomedical data among people of all ages. Chi-squared test for association and formal trend tests (2002, 2005, 2008 and 2012) were used to test for associations and trends in the HIV epidemic across the four surveys. In 2012 a total of 38 431 respondents were interviewed from 11 079 households; 28 997 (67.5%) of 42 950 eligible individuals provided blood specimens. HIV prevalence was 12.2% [95% CI: 11.4-13.1] in 2012 with prevalence higher among females 14.4% than males 9.9%. Adults aged 25-49 years were most affected, 25.2% [95% CI: 23.2-27.3]. HIV prevalence incr...



Gender inequality dynamics in the prevention of a heterosexual HIV epidemic in sub-Saharan Africa.

Fri, 25 Mar 2016 15:52:07 +0100

Authors: Wathuta J Abstract This paper critiques the approach to the elimination of gender inequality as an HIV prevention strategy in the just ended era of the Millennium Development Goals, with the aim of contributing to the formulation of policy guidelines for sub-Saharan Africa in the Sustainable Development Goals. The aim is to underscore the mutual responsibility of women and men in achieving a sustainable HIV response and ending the epidemic. While taking into account the real vulnerability of women, prevention programmes can reflect gender dynamics more accurately so that attention is given to the role of both sexes in propagating - or stemming - a predominantly heterosexual HIV epidemic. More emphasis could be given to the harm caused to both men and women by certain norms...



HIV/AIDS among pastoralists and refugees in north-east Africa: a neglected problem.

Fri, 25 Mar 2016 15:52:07 +0100

This article assesses vulnerability of pastoralists and refugee communities to HIV and interventions targeting these groups in the IGAD countries. Outcomes from this study may serve as a baseline for further research and to improve interventions. Published articles were accessed through web searches using PubMed and Google Scholar engines and unpublished documents were collected manually. The search terms were HIV risk behaviour, vulnerability, HIV prevalence and interventions, under the headings pastoralists, refugees, IGAD and north-east Africa for the period 2001-2014. Of the 214 documents reviewed, 78 met the inclusion criteria and were included. Most HIV/AIDS related studies focusing of pastoral communities in IGAD countries were found to be limited in scope and coverage but reveal pr...



Oral histories of HIV/AIDS support group members, NGO workers and home-based carers in KwaZulu-Natal.

Fri, 25 Mar 2016 15:52:07 +0100

Authors: Denis P Abstract The purpose of this paper is to bring to the attention of the AIDS research community the existence of an oral history project known as the Memories of AIDS Project. The project focused on HIV/AIDS support group members, non-governmental organisation (NGO) workers and home-based carers in the Umgungundlovu (Pietermaritzburg) District Municipality, South Africa. The project was carried out by the Sinomlando Centre for Oral History and Memory Work, a research and community development centre of the University of KwaZulu-Natal, over a period of three years (2011-2013). Sixty-five individual oral history interviews of 1 to 4 hours duration and 11 focus group sessions were recorded, transcribed and translated from isiZulu into English when necessary. The life s...

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The use of cash transfers for HIV prevention - are we there yet?

Fri, 25 Mar 2016 15:52:07 +0100

Authors: Taaffe J, Cheikh N, Wilson D Abstract Poverty and social inequality are significant drivers of the HIV epidemic and are risk factors for acquiring HIV. As such, many individuals worldwide are at risk for new HIV infection, especially young women in East and Southern Africa. By addressing these drivers, social protection programmes may mitigate the impact of poverty and social inequality on HIV risk. There is reason to believe that social protection can be used successfully for HIV prevention; social protection programmes, including cash transfers, have led to positive health outcomes and behaviour in other contexts, and they have been used successfully to promote education and increased income and employment opportunities. Furthermore, cash transfers have influenced sexual...



Involving parents from the start: formative evaluation for a large randomised controlled trial with Botswana Junior Secondary School students.

Fri, 25 Mar 2016 15:52:07 +0100

Authors: Vig J, Miller KS, Chirwa-Motswere C, Winskell K, Stallcup E Abstract While HIV prevention research conducted among adolescent populations may encounter parental resistance, the active engagement of parents from inception to trial completion may alleviate opposition. In preparation for implementing a large randomised controlled trial (RCT) examining the efficacy of a behavioural intervention targeting adolescent sexual risk behaviours, a formative evaluation was undertaken to assess parental reactions to the proposed trial. Six focus groups were conducted with parents of adolescents (aged 13-17) from rural, peri-urban and urban junior secondary schools in Botswana. Focus groups explored comprehension and acceptability among parents of the forthcoming trial including HSV-2 t...



Parental mediation of adolescent media use and demographic factors as predictors of Kenyan high school students' exposure to sexual content in television.

Fri, 25 Mar 2016 15:52:07 +0100

This study investigated the relationship between Kenyan adolescents' level of exposure to sexual television content and their parents' mediation of their television use. A cluster sample of 427 Nairobi public high school students was surveyed regarding parental mediation of their media use and their intake of sexual television content. Co-viewing with opposite sex friends was associated with higher intake of sexual TV content. This relationship was stronger among boarding school students than among day school students. Parental mediation and co-viewing variables predicted three times as much variance among boarding than among day school students. PMID: 27002353 [PubMed - in process] (Source: African Journal of AIDS Research)



Pretty Much Nobody In The U.S. Leads A Healthy Lifestyle

Fri, 25 Mar 2016 12:45:07 +0100

Only 2.7 percent of U.S. adults hit the four key metrics of living a healthy lifestyle -- abstaining from smoking, eating well, exercising and maintaining a healthy body fat percentage -- according to a disheartening new study. The study's lifestyle benchmarks for health weren't particularly high. Being smoke-free, exercising moderately and eating USDA recommended foods don't seem like particularly difficult marks to hit. So why do so many Americans fall short of living healthy lives?  "That is the million dollar question," Ellen Smit, a senior author of the study and an associate professor at the Oregon State University College of Public Health and Human Sciences, told The Huffington Post. "We did not look at why few Americans have healthy lifestyles in this study, but I can spe...



INTESTINAL AND PULMONARY INFECTION BY Cryptosporidium parvum IN TWO PATIENTS WITH HIV/AIDS.

Fri, 25 Mar 2016 12:16:02 +0100

We describe two patients with HIV/AIDS who presented pulmonary and intestinal infection caused by Cryptosporidium parvum, with a fatal outcome. The lack of available description of changes in clinical signs and radiographic characteristics of this disease when it is located in the extra-intestinal region causes low prevalence of early diagnosis and a subsequent lack of treatment. PMID: 27007564 [PubMed - in process] (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)

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Nigeria: Borno State Has Highest Rate of Syphilis - Expert

Fri, 25 Mar 2016 10:07:45 +0100

[This Day] The Head of Prevention, Department of Public Health and HIV/AIDS Division, Ministry of Health, Dr. Chukwuma Anyaike, has disclosed that recent findings from a national survey on serial prevalence of Syphilis in the country indicates that Borno State remains the state with highest cases of Syphilis. (Source: AllAfrica News: HIV-Aids and STDs)



Factors associated with loss to follow-up among women in Option B+ PMTCT programme in northeast Ethiopia: a retrospective cohort study.

Fri, 25 Mar 2016 08:59:02 +0100

CONCLUSIONS: The level of LFU we found in this study is comparable with previous findings from other resource-limited settings. However, high early LFU shortly after ART initiation is still a major problem. LFU was high among younger women, those initiating ART on the day of HIV diagnosis, those missing baseline CD4 count and those attending hospitals. Thus, targeted HIV care and treatment programmes for these patients should be part of future interventions to improve retention in care under the Option B+ PMTCT programme. PMID: 27005750 [PubMed - in process] (Source: Journal of the International AIDS Society)



Social patterns and differentials in the fertility transition in the context of HIV/AIDS: evidence from population surveillance, rural South Africa, 1993 – 2013

Fri, 25 Mar 2016 00:00:00 +0100

Literature is limited on the effects of high prevalence HIV on fertility in the absence of treatment, and the effects of the introduction of sustained access to antiretroviral therapy (ART) on fertility. We su... (Source: Population Health Metrics)



Sensors, Vol. 16, Pages 434: Balance Improvement Effects of Biofeedback Systems with State-of-the-Art Wearable Sensors: A Systematic Review

Thu, 24 Mar 2016 23:00:00 +0100

Falls and fall-induced injuries are major global public health problems. Balance and gait disorders have been the second leading cause of falls. Inertial motion sensors and force sensors have been widely used to monitor both static and dynamic balance performance. Based on the detected performance, instant visual, auditory, electrotactile and vibrotactile biofeedback could be provided to augment the somatosensory input and enhance balance control. This review aims to synthesize the research examining the effect of biofeedback systems, with wearable inertial motion sensors and force sensors, on balance performance. Randomized and non-randomized clinical trials were included in this review. All studies were evaluated based on the methodological quality. Sample characteristics, device design ...



Women of Color Reflect on HIV-Related Stigma through PhotoVoice

Thu, 24 Mar 2016 23:00:00 +0100

HIV-related stigma affects people living with HIV (PLWH), especially in communities of color. In our study, African American and Latina/Hispanic women living with HIV (WLWH) described experiences of stigma through PhotoVoice, a community-based participatory method of documentary photography. 10 WLWH from Los Angeles documented stigma experiences through photographs for up to 5 weeks and discussed their images during a focus group or semi-structured individual interview. Qualitative interpretive phenomenological analysis of participant narratives and photographs revealed lack of education and cultural myths as the main triggers of the stigma our participants faced. (Source: Journal of the Association of Nurses in AIDS Care)

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Tuberculosis Made Me Blind, But We Can Make Sure No One Else Needs to Suffer Like I Did

Thu, 24 Mar 2016 21:09:40 +0100

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CDC Media Statement on World TB Day 2016

Thu, 24 Mar 2016 19:34:29 +0100

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New findings in humans provide encouraging foundation for upcoming AIDS vaccine clinical trial

Thu, 24 Mar 2016 19:00:47 +0100

Some people infected with HIV naturally produce antibodies that effectively neutralize many strains of the rapidly mutating virus, and scientists are working to develop a vaccine capable of inducing such "broadly neutralizing" antibodies that can prevent HIV infection. (Source: ScienceDaily Headlines)



Prom Dresses Made Out Of Condoms Aim To Promote Safe Sex

Thu, 24 Mar 2016 18:36:36 +0100

Here’s one way to dress for succ-sex. As prom season looms, a local effort in Omaha is encouraging teens to practice safe sex by putting condoms front and center of their party prep, WOWT 6 News reported. At two area stores, shoppers will find bold dresses made entirely from condoms among the racks of festive wear. But instead of listing a price, the accompanying tags bear a foreboding message: “Being safe is always in style. Avoid sexually transmitted diseases and unintended pregnancies." The campaign was launched by Adolescent Health Project and the Women's Fund of Omaha in hopes of combating the city’s surging STD rates. In 2012, more than 4,400 STD cases were reported in Douglas County, according to Get Checked Omaha. The area’s instances of gonorrhea and chlamy...



NLM Accepting Proposals for HIV/AIDS Community Information Outreach Projects 2016

Thu, 24 Mar 2016 18:13:32 +0100

The National Library of Medicine (NLM) is pleased to announce the solicitation of quotations from organizations and libraries to design and conduct projects for improving HIV/AIDS information access for patients and the affected community as well as their caregivers and the general public. Patients and the affected community need access to the most up-to-date and accurate health information to effectively manage and make informed decisions about their health.  Health care providers and health educators also need access to the most current information to provide the highest quality of care. NLM is committed to assisting organizations in accessing the spectrum of information resources and services that are currently available.  The NLM is particularly interested in proposals with creative ...

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This Disease Can Still Get You Quarantined For Months -- And It's On The Rise

Thu, 24 Mar 2016 17:08:03 +0100

In August 2014, Kate O’Brien, a 34-year-old media producer from Brooklyn, found out she was expecting her second child. She was ecstatic. But this pregnancy didn't proceed like the first. For the next few months, O'Brien had a cold she couldn't shake. She woke up in the middle of the night drenched in sweat. She wanted to blame it on her pregnancy, yet she kept losing weight. She could barely eat. She coughed up balls of bloody mucus. Her throat burned. None of her doctors could figure out what was wrong. A physician sent her to Mount Sinai West Hospital in Manhattan in January 2015, when, at five months pregnant, she still couldn't gain any weight. "No one likes a skinny pregnant lady," she said. O'Brien expected to stay at the hospital overnight. She didn’t get a chance to sa...



58 Stunning Photos That Show The Bond Between Moms And Doulas

Thu, 24 Mar 2016 15:45:20 +0100

For many parents, birth doulas are beacons of calming encouragement who enhance the labor, delivery and postpartum experience in incomparable ways.  An ancient Greek word for female servant, "doula" today refers to a trained helper who aids laboring mothers by providing expertise and emotional support and advocating for their birth needs and desires.  Doulas are increasingly prevalent in U.S. birth culture, spawning praise-filled blog posts and studies about their positive impact on pregnancy and childbirth. In honor of World Doula Week, here are 58 incredible photos of doulas in action in the U.S. and beyond, along with captions from the photographers who witnessed the magic.  -- This feed and its contents are the property of The Huffington Post, and use is subjec...



HIV/AIDS Strategy Goals for HIV Linkage and Retention in CareHIV/AIDS Strategy Goals for HIV Linkage and Retention in Care

Thu, 24 Mar 2016 15:03:18 +0100

This brief summarizes recommendations derived from a network of HIV/AIDS agencies, highlighting strategies to overcome challenges in designing successful HIV linkage and retention in care programs. American Journal of Public Health (Source: Medscape Hiv-Aids Headlines)



Factors associated with HIV viral load "blips" and the relationship between self-reported adherence and efavirenz blood levels on blip occurrence: a case-control study.

Thu, 24 Mar 2016 14:01:02 +0100

CONCLUSION: Blips are commonly encountered in the clinical management of HIV-infected patients. Although blip occurrence was not associated with SRA or EFV blood levels in our study, blips were associated with HIV-related factors of pre-ART high VL and low CD4 count. Additional studies are needed to determine the etiology of blips in HIV-infected patients. PMID: 27006682 [PubMed] (Source: AIDS Research and Therapy)



Cameroon: HIV/TB Subvention - Reduce Mortality, Scale up Treatment

Thu, 24 Mar 2016 10:04:49 +0100

[Cameroon Tribune] The over FCFA 60 billion from the Global Fund is timely in assisting the government of Cameroon to curb HIV and tuberculosis. (Source: AllAfrica News: HIV-Aids and STDs)

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He Looks At Tuberculosis Death Toll And Wonders Why You're Not Worried

Thu, 24 Mar 2016 10:00:22 +0100

Aaron Motsoaledi is tired of delivering the same spiel over and over again. No matter how many times the charismatic health minister of South Africa speaks out, people don’t seem to grasp the threat presented by tuberculosis, now the No. 1 infectious killer in the world. “People think it’s a curable disease that’s been there for ages, so what’s new? I think that’s the mentality,” Dr. Motsoaledi told The Huffington Post. As chair of the Stop TB Partnership, a group of public and private leaders hosted through the United Nations Office for Project Service, he has seen the eyes of bureaucrats around the world glaze over when he brings up TB. And yet 4,100 people die every day from the disease. His own country is one of the hardest hit. Motsoaledi...



In vitro evaluation of probiotic potential of five lactic acid bacteria and their antimicrobial activity against some enteric and food-borne pathogens

Thu, 24 Mar 2016 07:26:18 +0100

Lactic acid bacteria (LAB) present many important properties in food manufacturing, such as improvement of physical characteristics and the production of lactic acid that aids in the increase of the shelf life of food products. Also, LAB can suppress growth of pathogens, control of serum cholesterol level, modulate immune system, and improve lactose digestion. Five standard (Lactobacillus pa... (Source: African Journal of Microbiology Research)



EGPAF wins award to scale up innovative PMTCT medications in Uganda

Thu, 24 Mar 2016 04:00:00 +0100

(Elizabeth Glaser Pediatric AIDS Foundation) The Elizabeth Glaser Pediatric AIDS Foundation has been selected to receive the prestigious Saving Lives at Birth: A Grand Challenge for Development Award for its model to nationally scale up use of the innovative 'Pratt Pouch' to prevent mother-to-child transmission of HIV in Uganda. EGPAF's model will introduce the easy-to-use pouches during antenatal care, delivery, and postnatal care services in Uganda with the goal of reaching 40,000 infants in three years. (Source: EurekAlert! - Medicine and Health)



Passive immunization with HIV‐1–neutralizing antibodies: Is it effective and safe?

Wed, 23 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Oral Diseases)



The contribution of virtual reality to the diagnosis of spatial navigation disorders and to the study of the role of navigational aids: A systematic literature review

Wed, 23 Mar 2016 23:00:00 +0100

Conclusion Unlike pencil-and-paper tests, virtual reality is useful to assess large-scale navigation strategies in patients with brain injury or schizophrenia, or in the context of ageing and dementia. Better knowledge about both the impact of the different aids and the cognitive processes involved is essential for the use of aids in neurorehabilitation. (Source: Annals of Physical and Rehabilitation Medicine)

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Experimental Systems for Studying Plasmodium‐HIV coinfection

Wed, 23 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: FEBS Letters)



Novel mechanisms of human immunodeficiency virus induced central nervous system dysfunction.

Wed, 23 Mar 2016 23:00:00 +0100

CONCLUSION: In the current manuscript, we have described the mechanisms by which HIV "hijacks" these host cellular communication systems, leading to exacerbation of HIV neuropathogenesis, and to simultaneously promote the survival of HIV infected cells, resulting in the establishment of viral reservoirs. PMID: 27009098 [PubMed - as supplied by publisher] (Source: Current HIV Research)



Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse.

Wed, 23 Mar 2016 23:00:00 +0100

CONCLUSION: In this review, we will provide the latest updates of the molecular mechanisms that regulate HIV transcription and discuss how drugs of abuse, such as cocaine, amphetamine, methamphetamine, heroin and morphine, modulate those mechanisms to upregulate HIV transcription and eventually HIV replication. PMID: 27009097 [PubMed - as supplied by publisher] (Source: Current HIV Research)



Multiple Faceted Roles of Cocaine in Potentiation of HAND.

Wed, 23 Mar 2016 23:00:00 +0100

CONCLUSION: This review highlights previous studies in the field on the role of cocaine in the progression of HAND and gives an overview of the major signaling pathways in the CNS that are involved in this process. PMID: 27009095 [PubMed - as supplied by publisher] (Source: Current HIV Research)



HIV-1 Latency and Eradication: Past, Present and Future.

Wed, 23 Mar 2016 23:00:00 +0100

CONCLUSION: Current efforts to eradicate HIV-1 from this cell population focus primarily on a "shock and kill" approach through cellular reactivation to trigger elimination of virus producing cells by cytolysis or host immune responses. However, studies revealed several limitations to this approach that require more investigation to assess its clinical application. Recent advances in gene editing technology prompted use of this approach for inactivating integrated proviral DNA in the genome of latently infected cells. This technology, which requires a detailed understanding of the viral genetics and robust delivery, may serve as a powerful strategy to eliminate the latent reservoir in the host leading to a sterile cure of AIDS. PMID: 27009094 [PubMed - as supplied by publisher] (Source...

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Lin28 and let-7: Roles and Regulation in Liver Diseases.

Wed, 23 Mar 2016 23:00:00 +0100

Authors: McDaniel K, Hall C, Sato K, Lairmore T, Marzioni M, Glaser S, Meng F, Alpini G Abstract The diagnosis and treatment of liver disease remains a major health concern worldwide due to its diverse etiologies. New therapeutic targets are greatly needed to halt disease progression. Upon initiation of liver injury by viral infection, autoimmune disease or toxin, hepatitis and/or cholangitis may develop which can progress to cirrhosis, hepatocellular carcinoma, cholangiocarcinoma, liver failure or death. Lin28 is a stem cell marker vital for maintaining a stem cell phenotype. Inhibition of Lin28 induces cellular differentiation, whereas overexpression of Lin28 promotes cell transformation to a stem cell phenotype. Lin28 has not been extensively studied in the liver despite its cap...



Brain Stimulation After Stroke Aids RecoveryBrain Stimulation After Stroke Aids Recovery

Wed, 23 Mar 2016 22:19:03 +0100

Combined with rehabilitation, transcranial direct-current brain stimulation improved function compared with a sham procedure, a new study shows. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)