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MedWorm: Herpes provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Herpes category.

Last Build Date: Tue, 29 Mar 2016 16:32:09 +0100


Herpes Zoster Ophthalmicus: Declining Age at PresentationHerpes Zoster Ophthalmicus: Declining Age at Presentation

Tue, 29 Mar 2016 10:23:34 +0100

Patients presenting with herpes zoster involving the eye are younger than in previous years, and the incidence is increasing. What accounts for the change? The British Journal of Ophthalmology (Source: Medscape Today Headlines)

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Prevalence of genital herpes in HIV positive patients attending STI clinic at a tertiary care hospital and its correlation with CD4 counts

Tue, 29 Mar 2016 09:23:37 +0100

Background: HIV infection is emerging as one of the major health problems faced by the clinicians across the world, more so because of co-existence of many sexually transmitted infections (STIs) among HIV infected patients. The presence of untreated STIs (both ulcerative and non-ulcerative) increases the risk of both acquisition and transmission of HIV by a factor of upto 10 times. Recurrent and persistent ulcerative HSV2 lesions are among the common infections in HIV patients. Prevalence of genital herpes has increased markedly between the 1970's and 1990's. (Source: International Journal of Infectious Diseases)

HSV positivity in bronco-alveolar lavage fluid and clinical outcome in hospitalized patients

Tue, 29 Mar 2016 09:23:36 +0100

Background: Herpes Simplex virus (HSV) is highly prevalent and ubiquitously distributed worldwide. It is responsible for a wide variety of clinical manifestations with a generally benign course in immunocompetent individuals and a worse prognosis in the immunocompromised. (Source: International Journal of Infectious Diseases)

Real time PCR for the diagnosis of Rubella Virus, Herpes Simplex virus-1 and Toxoplasma gondii in patients with congenital cataract

Tue, 29 Mar 2016 09:23:35 +0100

Background: Congenital cataract is most serious type of cataract and has the potential for inhibiting early visual development. Intrauterine infections with Rubella virus (RV), Herpes simplex virus-1 (HSV) and Toxoplasma gondii play an important role in the development of congenital cataract. The aim of present study was to know the contribution of RV, HSV-1 and T.gondii towards congenital cataract in children attending a tertiary care hospital in North India. (Source: International Journal of Infectious Diseases)

Viral etiology of anterior uveitis in immunocompetent patients in North India

Tue, 29 Mar 2016 09:23:35 +0100

Background: Uveitis is the leading cause of blindness worldwide. Among various forms, the anterior uveitis is most common. Herpes simplex virus (HSV) and varicella zoster virus (VZV) are known to cause anterior uveitis. However, recent studies have also reported the role of human cytomegalovirus (HCMV) in the causation of anterior uveitis in immunocompetent individuals. The present study aimed to study the prevalence of HSV-1, VZV and HCMV in patients presenting with anterior uveitis in a tertiary care hospital in North India. (Source: International Journal of Infectious Diseases)

Eosinophilic Drug Allergy

Tue, 29 Mar 2016 06:27:36 +0100

Abstract While peripheral or tissue eosinophilia may certainly characterize drug eruptions, this feature is hardly pathognomonic for a medication-induced etiology. While delayed drug hypersensitivity reactions with prominent eosinophilic recruitment have been typically classified as type IVb reactions, their pathophysiology is now known to be more complex. Eosinophilic drug reactions have a diversity of presentations and may be benign and self-limited to severe and life-threatening. The extent of clinical involvement is also heterogeneous, ranging from isolated peripheral eosinophilia or single organ involvement (most often the skin and lung) to systemic disease affecting multiple organs, classically exemplified by drug-reaction with eosinophilia and systemic symptoms (DRESS). Th...

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Pd28-12 a phase 1 study of a third-generation oncolytic hsv-1 g47Δ in patients with castration resistant prostate cancer

Mon, 28 Mar 2016 19:24:10 +0100

Oncolytic herpes simplex viruses type 1 (HSV-1) is an attractive therapeutic agent for treating cancer due to its capacity to selectively replicate in cancer cells, kill them, and spread their progeny to surrounding cancer cells. Recently, FDA approved IMLYGIC™ (Talimogene laherparepvec) as the first oncolytic virus drug in developed countries. IMLYGIC is a second-generation oncolytic HSV-1 that showed a higher durable response rate and a better overall survival in the group of advanced malignant melanoma patients than the control group. (Source: The Journal of Urology)

Mp30-04 herpes simplex virus (hsv) vector-mediated gene delivery of poreless trpv1 channels or protein phosphate 1α (pp1α) reduces bladder overactivity and nociception in rat model of cystitis induced by hydrogen peroxide

Mon, 28 Mar 2016 19:24:06 +0100

It has been reported that increased afferent excitability is an important pathophysiological basis of interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB) and that transient receptor potential vanilloid-1 (TRPV1) receptors greatly contribute to afferent sensitization. Animals with hydrogen peroxide (HP)-induced cystitis have recently been introduced as a model that mimics pathologic features of chronic inflammatory bladder condition. Therefore, we investigated the effect of gene therapy with HSV vectors encoding poreless TRPV1 or PP1α (negative TRPV1 modulator) in rats with HP-induced cystitis. (Source: The Journal of Urology)

Plasma Therapy: No New Knees Needed

Mon, 28 Mar 2016 05:00:00 +0100

SALT LAKE CITY. (Ivanhoe Newswire) -- The FDA says about 74,000 Americans were diagnosed with melanoma, a type of skin cancer. Last year, nearly 10,000 of them died of it. Now, researchers have a new weapon in their arsenal; one that comes from a genetically-altered herpes virus. Here’s more about the first cancer-killing viral therapy ever approved in the U.S. (Source: Medical Headlines From

Herpes zoster in an infant without postnatal varicella infection

Sun, 27 Mar 2016 22:00:00 +0100

(Source: JDDG)

Perianal Herpes Simplex Virus Infection Misdiagnosed With Pyoderma Gangrenosum: Case of the Month from the Case Consultation Committee of the International Society for the Study of Vulvovaginal Disease

Sat, 26 Mar 2016 08:13:16 +0100

No abstract available (Source: Journal of Lower Genital Tract Disease)

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Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo.

Fri, 25 Mar 2016 17:35:02 +0100

This study provides further experimental data to confirm the potential of VP22-based intercellular delivery strategies for enhancing the efficacy of gene therapy for cancer treatment. PMID: 27004535 [PubMed - as supplied by publisher] (Source: Oncology Reports)

Protein Phosphatase, Mg2+/Mn2+-dependent 1A controls the innate antiviral and antibacterial response of macrophages during HIV-1 and Mycobacterium tuberculosis infection.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Sun J, Schaaf K, Duverger A, Wolschendorf F, Speer A, Wagner F, Niederweis M, Kutsch O Abstract Co-infection with HIV-1 and Mycobacterium tuberculosis (Mtb) is a major public health issue. While some research has described how each pathogen accelerates the course of infection of the other pathogen by compromising the immune system, very little is known about the molecular biology of HIV-1/Mtb co-infection at the host cell level. This is somewhat surprising, as both pathogens are known to replicate and persist in macrophages. We here identify Protein Phosphatase, Mg2+/Mn2+-dependent 1A (PPM1A) as a molecular link between Mtb infection and increased HIV-1 susceptibility of macrophages. We demonstrate that both Mtb and HIV-1 infection induce the expression of PPM1A in primary...

Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports‏.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes. PMID: 27003735 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

Clinical monitoring: infliximab biosimilar CT-P13 in the treatment of Crohn's disease and ulcerative colitis.

Fri, 25 Mar 2016 06:03:02 +0100

Conclusions This prospective observational study provides evidence of the effectiveness of CT-P13 in IBD. PMID: 27002981 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)

Letter to the Editor regarding the paper by Sun G et al: Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy. J Neuro Sci 2015;349:190–195

Thu, 24 Mar 2016 23:00:00 +0100

We read with great interest the discussion of possible therapeutic potential of anti-elastase agents against influenza virus-associated encephalopathy (IE) in the clinical research paper by Sun et al. [1]. Recently, we had an opportunity to examine the kinetics of serum neutrophil elastase (NE) in the acute clinical course of three patients, aged 12 to 14months, who were diagnosed with human herpes virus 6 (HHV6)-associated acute encephalopathy with febrile convulsive status epilepticus (AEFCSE), one of whom had moderate neurological sequelae with secondary epilepsy and developmental retardation. (Source: Journal of the Neurological Sciences)

Sex differences in the incidence of skin and skin‐related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide

Thu, 24 Mar 2016 15:22:23 +0100

Abstract Many skin and skin‐related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin‐related diseases affecting males vs. females, we reviewed published population‐based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers. Males had a higher incidence of ...

A case report of immunosuppression-related Kaposi’s sarcoma after autologous stem cell transplantation

Thu, 24 Mar 2016 00:00:00 +0100

Kaposi’s sarcoma (KS) is a tumor formed by angioproliferations driven by Human herpes virus 8 also known as Kaposi’s sarcoma-associated herpes virus (KSHV). It is best known as an acquired immune deficiency sy... (Source: BMC Research Notes)

Herpes simplex uveitis as a cause of persistent high intraocular pressure after cataract surgery

Wed, 23 Mar 2016 23:00:00 +0100

(Source: Clinical and Experimental Ophthalmology)

Id: 51: chemotherapeutic potential of lipoxins in kaposi's sarcoma and primary effusion lymphoma

Mon, 21 Mar 2016 23:00:00 +0100

In conclusion, our study suggests that Lipoxins have therapeutic potential for PEL and should be explored in KS and other PEL cell types. (Source: Journal of Investigative Medicine)

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A trapping ligand antagonist peptide H22-LP inhibition of human cytomegalovirus infection

Mon, 21 Mar 2016 23:00:00 +0100

Conclusion These results demonstrated that H22-LP could inhibit HCMV by direct interaction with the viral particle. (Source: Journal of Microbiology, Immunology and Infection)

First HSV-1 Non Primary Genital Herpes in two patients

Mon, 21 Mar 2016 23:00:00 +0100

Although HSV-1 has become a common cause of primary genital herpes, the two cases we report are, to our knowledge, the first documented first episodes of HSV-1 genital herpes in patients in whom there is evidence of prior HSV-2 infection. Beyond proving that this situation is possible, they call forth the following questions: why had such cases not been documented before, are they indeed rare? if so why? are prior encounters with one herpes simplex genotype protective against the other? (Source: Journal of Clinical Virology)

Controversial New Push to Tie Microbes to Alzheimer's Disease

Mon, 21 Mar 2016 20:00:00 +0100

A journal article says herpes virus and Lyme disease bacteria are behind the mind-robbing illness, but not all researchers are convinced -- Read more on (Source: Scientific American)

Featured Review: Vaccines for preventing herpes zoster in older adults

Mon, 21 Mar 2016 18:36:04 +0100

Vaccine helps prevent shingles in older adults for up to three years The varicella zoster virus causes chickenpox and can remain dormant inside nerve cells. After many years, it can reactivate and travel through the nerve to the skin, causing itching, numbness, tingling or local pain, and then blisters along the nerve path. These blisters are often accompanied with inflammation of the nerves and severe pain, which can affect quality of life. This is called herpes zoster or shingles. It affects people with low immunity such as older people. There are about 5.22 episodes of shingles for every 1000 older people. This is increasing, in part because people are living longer.A team of Cochrane authors based in Brazil worked with the Cochrane Acute Respiratory Infections Group to investigate...

Herpes Virus Fights Cancer?

Mon, 21 Mar 2016 05:00:00 +0100

SALT LAKE CITY. (Ivanhoe Newswire) -- The FDA says about 74,000 Americans were diagnosed with melanoma, a type of skin cancer. Last year, nearly 10,000 of them died of it. Now, researchers have a new weapon in their arsenal; one that comes from a genetically-altered herpes virus. Here’s more about the first cancer-killing viral therapy ever approved in the U.S. (Source: Medical Headlines From

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The Natural History of Human Polyomaviruses and Herpesviruses in Early Life--The Rhea Birth Cohort in Greece

Mon, 21 Mar 2016 00:00:00 +0100

Sparse data exist on the patterns and determinants of acquisition of polyomaviruses and herpesviruses in childhood. We measured immunoglobulin G seroreactivity against 10 polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, HPyV10) and 5 herpesviruses (Epstein Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus types 1 and 2, human herpesvirus 8) using multiplex serology on blood samples collected at birth (cord blood, n = 626) and at follow-up at 3 years (n = 81) and 4 years (n = 690) of age among the Rhea birth cohort recruited in Greece from pregnant women in 2007–2008. We used Poisson regression with robust variance to identify determinants of seropositivity at age 4. Seroprevalence of polyomaviruses ranged from 38.5% to 99.8% in cord blood and...

Arterial Spin-labeling in Central Nervous System Infection.

Sun, 20 Mar 2016 23:00:00 +0100

CONCLUSIONS: The characteristics of ASL-MRI in CNS infections were clearly delineated. ASL-MRI could be helpful for monitoring the brain function in CNS infections noninvasively. PMID: 27001393 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medical Sciences : MRMS)

[Sexually transmitted infections in male prison inmates: risk of development of new diseases].

Sat, 19 Mar 2016 12:06:02 +0100

CONCLUSION: The most important risk factors in prison are behaviours related to STIs and previous history of STIs. Other factors are being a repeat offender, injecting drug use, or being in a methadone programme. Health personnel and peer education can facilitate prevention and control. PMID: 26987281 [PubMed - as supplied by publisher] (Source: Gaceta Sanitaria)

Molecules, Vol. 21, Pages 383: A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc

Sat, 19 Mar 2016 00:00:00 +0100

Zanthoxylum schinifolium Sieb. et Zucc. (Rutaceae), a dioecious shrub with hooked prickly branches, has been used as folk medicine for the treatment of the common cold, stomach ache, diarrhea, and jaundice in China, Korea, and Japan. In our phytochemical investigations on this genus, a new megastigmane sesquiterpenoid, which is referred to as schinifolenol A (1), was isolated from Z. schinifolium. The stereochemistry was characterized via the analyses of extensive spectra. The absolute configuration was established by the application of a modified Mosher’s experiment and assisted by a time-dependent density functional theory (TD-DFT) on calculated electronic circular dichroism (ECD). Bioactivity screenings showed that compound 1 exhibited a safe hypotoxicity and a better selectivity on a...

Chapter Two Alphaherpesvirus Latency

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: 2016 Source:Advances in Virus Research, Volume 94 Author(s): David C. Bloom Alphaherpesviruses infect a variety of species from sea turtles to man and can cause significant disease in mammals including humans and livestock. These viruses are characterized by a lytic and latent state in nerve ganglia, with the ability to establish a lifelong latent infection that is interrupted by periodic reactivation. Previously, it was accepted that latency was a dominant state and that only during relatively infrequent reactivation episodes did latent genomes within ganglia become transcriptionally active. Here, we review recent data, focusing mainly on Herpes Simplex Virus type 1 which indicate that the latent state is more dynamic than recently appreciated. (Source: Advances in Vi...

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KIR2DL2 inhibitory pathway enhances Th17 cytokine secretion by NK cells in response to herpesvirus infection in multiple sclerosis patients

Sat, 19 Mar 2016 00:00:00 +0100

We have previously demonstrated that Multiple Sclerosis (MS) patients with KIR2DL2 expression on Natural killer (NK) cells are more susceptible to herpes simplex virus 1 (HSV-1) infection. We explored cytokine expression by NK cells during HSV-1 infection in association with KIR2DL2 expression. MS KIR2DL2+ NK cells failed to control HSV-1 infection and secreted high levels of Th17 cytokines, while MS KIR2DL2− NK cells released Th1 cytokines, mainly IFN-gamma. Our data showed, for the first time, a peculiar Th17 cytokine secretion by MS KIR2DL2+ NK cells in the presence of HSV-1 infection, that could be implicated in MS pathogenesis. (Source: Journal of Neuroimmunology)

Systemic Immunosuppression in High-Risk Penetrating Keratoplasty: A Systematic Review.

Fri, 18 Mar 2016 20:38:02 +0100

Authors: Bali S, Filek R, Si F, Hodge W Abstract Cornea transplantation has a high success rate and typically only requires topical immunomodulation. However, in high-risk cases, systemic immunosuppression can be used. We conducted a systematic review on the efficacy and side effects of systemic immunosuppression for high-risk cornea transplantation. The study population was 18 years old or older with a high-risk transplant (two or more clock hours of cornea vascularization or a previous failed graft or a graft needed because of herpes simplex keratitis). A comprehensive search strategy was performed with the help of an information specialist and content experts from ophthalmology. All study designs were accepted for assessment. Level 1 and level 2 screening was performed by two re...

Accumulation of a soluble form of human nectin-2 is required for exerting the resistance against herpes simplex virus type 2 infection in transfected cells.

Fri, 18 Mar 2016 15:12:02 +0100

Authors: Fujimoto Y, Ozaki K, Iwamori N, Takakuwa H, Ono E Abstract Cell entry of herpes simplex virus type 2 (HSV-2) requires the interaction of viral glycoprotein D (gD) with the receptor nectin-1 and herpesvirus entry mediator (HVEM). In addition, it is known that nectin-2 is also functional as a receptor for HSV-2, although the binding to the gD is weak. To examine an antiviral potential of a soluble form of human nectin-2 (hNectin-2Ig), transfected Vero cells expressing the entire ectodomain of nectin-2 fused to the Fc portion of human IgG were established. Specific binding of hNectin-2Ig to HSV-2 gD was confirmed by ELISA. Competitive ELISA demonstrated that accumulation of hNectin-2Ig in transfected cells increased significantly in a cell culture time dependent manner. Vi...

Immunogenic cell death by oncolytic herpes simplex virus type 1 in squamous cell carcinoma cells

Fri, 18 Mar 2016 00:00:00 +0100

Authors: A Takasu, A Masui, M Hamada, T Imai, S Iwai & Y Yura (Source: Cancer Gene Therapy)

Risk of Herpes Zoster in Auto‐immune and Inflammatory diseases: Implications for Vaccination

Fri, 18 Mar 2016 00:00:00 +0100

Conclusions: SLE, IBD and RA are associated with higher risks of HZ compared to older adults recommended for vaccination, suggesting that individuals with these conditions as young as age 40 could potentially benefit from vaccination. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)

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The Epidemiology of Herpes Zoster After Varicella Immunization Under Different Biological Hypotheses: Perspectives From Mathematical Modeling.

Fri, 18 Mar 2016 00:00:00 +0100

Authors: Guzzetta G, Poletti P, Merler S, Manfredi P Abstract The impact of varicella vaccination on the epidemiology of herpes zoster (HZ) critically depends on the mechanism of immunological boosting, through which reexposures to varicella-zoster virus are thought to reduce the individual risk of HZ development. However, the qualitative and quantitative dynamics of this process are largely unknown. Consequently, mathematical models evaluating immunization strategies need to rely on theoretical assumptions. Available varicella-zoster virus models can be classified in 3 main families according to the postulated effect of exogenous boosting: 1) progressive accumulation of immunity following repeated reexposures; 2) partial protection that wanes over time; or 3) full but temporary im...

Are herpes virus associated to aggressive periodontitis? A review of literature.

Thu, 17 Mar 2016 17:22:02 +0100

Authors: Rodrigues PM, Teixeira AL, Kustner EC, Medeiros R Abstract Periodontal Disease includes a wide variety of infectious entities with various clinical manifestations in the oral cavity and responses to treatment. The determinants of clinical manifestations of periodontal disease include the type of infectious agent, the host immune response and environmental factors. Aggressive periodontitis (AP) is defined as a type of inflammation with specific clinical and laboratory features, which distinguish it from other types of periodontitis, with high incidence rates in a sub-group of individuals. Bacteria have been frequently mentioned as the agent inciting gingival inflammation and tissue destruction that underlies the pathogenesis of periodontitis. However, recent studies, with s...

Viruses, Vol. 8, Pages 83: Subcellular Trafficking and Functional Relationship of the HSV-1 Glycoproteins N and M

Thu, 17 Mar 2016 00:00:00 +0100

The herpes simplex virus type 1 (HSV-1) glycoprotein N (gN/UL49.5) is a type I transmembrane protein conserved throughout the herpesvirus family. gN is a resident of the endoplasmic reticulum that in the presence of gM is translocated to the trans Golgi network. gM and gN are covalently linked by a single disulphide bond formed between cysteine 46 of gN and cysteine 59 of gM. Exit of gN from the endoplasmic reticulum requires the N-terminal core of gM composed of eight transmembrane domains but is independent of the C-terminal extension of gM. Co-transport of gN and gM to the trans Golgi network also occurs upon replacement of conserved cysteines in gM and gN, suggesting that their physical interaction is mediated by covalent and non-covalent forces. Deletion of gN/UL49.5 using bacterial a...

Herpes simplex virus-1 encephalitis induced by chemoradiotherapy and steroids in an esophageal cancer patient: a case report

Thu, 17 Mar 2016 00:00:00 +0100

Systemic chemotherapy combined with steroids used as prophylactic antiemetics have been reported to induce immunosuppression. Further, herpes simplex virus-1 (HSV-1) infection has been reported to occur in pat... (Source: BMC Cancer)

Elaboration of a clinical and paraclinical score to estimate the probability of herpes simplex virus encephalitis in patients with febrile, acute neurologic impairment

Wed, 16 Mar 2016 23:00:00 +0100

Abstract Herpes simplex virus (HSV) encephalitis is associated with a high risk of mortality and sequelae, and early diagnosis and treatment in the emergency department are necessary. However, most patients present with non-specific febrile, acute neurologic impairment; this may lead clinicians to overlook the diagnosis of HSV encephalitis. We aimed to identify which data collected in the first hours in a medical setting were associated with the diagnosis of HSV encephalitis. We conducted a multicenter retrospective case–control study in four French public hospitals from 2007 to 2013. The cases were the adult patients who received a confirmed diagnosis of HSV encephalitis. The controls were all the patients who attended the emergency department of Grenoble hospital with a febril...

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Varicella and zoster optimal control

Wed, 16 Mar 2016 00:00:00 +0100

Herpes zoster arises from reactivation of the varicella–zoster virus (VZV), causing varicella in children. As reactivation occurs when cell-mediated immunity (CMI) declines, and there is evidence that re-exposure to VZV boosts CMI, mass varicella immunization might increase the zoster burden, at least for some decades. Fear of this natural zoster boom is the main reason for the paralysis of varicella immunization in Europe. We apply optimal control to a realistically parametrized age-structured model for VZV transmission and reactivation to investigate whether feasible varicella immunization paths that are optimal in controlling both varicella and zoster exist. We analyse the optimality system numerically focusing on the role of the cost functional, of the relative zoster–varic...

Medical News Today: Herpes virus and EBV could be tackled by heart drug

Tue, 15 Mar 2016 07:00:00 +0100

An existing drug for heart disease has proved effective in blocking herpes infection, potentially offering an alternative that could help in cases of drug-resistant infection. (Source: Health News from Medical News Today)

Systemic versus local responses in melanoma patients treated with talimogene laherparepvec from a multi-institutional phase II study

Tue, 15 Mar 2016 00:00:00 +0100

Conclusions These results support a regional and systemic effect of talimogene laherparepvec immunotherapy in patients with advanced melanoma. (Source: Journal for Immunotherapy of Cancer)

3-D cell placenta model mimics development, microbial resistance

Tue, 15 Mar 2016 00:00:00 +0100

Researchers developed a 3-D cell culture system that may aid in understanding how pathogens that cause diseases such as herpes, HIV, and Zika can pass from mother to fetus. (Source: NIH Research Matters from the National Institutes of Health (NIH))

Seroprevalence and risk factors of herpes simplex virus-2 among pregnant women attending antenatal care at health facilities in Wolaita zone, Ethiopia

Tue, 15 Mar 2016 00:00:00 +0100

Herpes simplex virus type-2 is the common cause of genital ulcer disease worldwide. Genital herpes infection is a major concern in pregnancy due to the risk of neonatal transmission. (Source: Virology Journal)

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Viruses, Vol. 8, Pages 81: Alphaherpesvirus Subversion of Stress-Induced Translational Arrest

Tue, 15 Mar 2016 00:00:00 +0100

In this article, we provide an overview of translational arrest in eukaryotic cells in response to stress and the tactics used specifically by alphaherpesviruses to overcome translational arrest. One consequence of translational arrest is the formation of cytoplasmic compartments called stress granules (SGs). Many viruses target SGs for disruption and/or modification, including the alphaherpesvirus herpes simplex virus type 2 (HSV-2). Recently, it was discovered that HSV-2 disrupts SG formation early after infection via virion host shutoff protein (vhs), an endoribonuclease that is packaged within the HSV-2 virion. We review this discovery and discuss the insights it has provided into SG biology as well as its potential significance in HSV-2 infection. A model for vhs-mediated disruption o...

Hidden in plain sight: Well-known drug could yield new treatment for herpes viruses

Mon, 14 Mar 2016 04:00:00 +0100

(University of Utah Health Sciences) In a search for new antiviral drugs, University of Utah scientists found that a common heart failure medicine, spironolactone, has an unexpected ability to block Epstein Barr virus (EBV). The drug blocks a key step in viral infection common to all herpesviruses, revealing that it could be developed into a new class of drug to treat infections caused by herpesviruses including herpes, shingles, and mono. The research was published in PNAS. (Source: EurekAlert! - Infectious and Emerging Diseases)

Field testing primary stabbing headache criteria according to the 3rd beta edition of International Classification of Headache Disorders: a clinic-based study.

Mon, 14 Mar 2016 03:46:02 +0100

CONCLUSIONS: All patients with headache with stabbing pain without cranial autonomic symptoms fulfilled the diagnostic criteria for PSH according to ICHD-3 beta at the initial visit. Secondary causes for headache with stabbing pain were revealed in a small proportion (3.7 %) of patients after 2 weeks of follow-up. PMID: 26969185 [PubMed - as supplied by publisher] (Source: Herpes)

Connections between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis.

Mon, 14 Mar 2016 00:00:00 +0100

Authors: McNamara J, Murray TA Abstract Alzheimer's disease (AD) is currently one of the most studied neurodegenerative disorders in humans. First reported in 1907, the disease has a familial form which represents approximately 5% of cases, while the remaining, sporadic cases are of multifactorial etiology. The disease progression of the latter form has specific pathological and functional characteristics, which have unknown etiology. Several authors have proposed a viral etiology for AD, while others implicate many neurotropic infectious agents. This review compares research findings regarding pathways and effects of neuropathological viruses with the pathways and effects involved in the progression of AD. The similarities are striking and provide a compelling argument for a patho...

Metabotropic glutamate receptor type 1 autoimmunity: Clinical features and treatment outcomes

Mon, 14 Mar 2016 00:00:00 +0100

Conclusions: mGluR1 autoimmunity represents a treatable form of cerebellar ataxia. Dysgeusia may be a diagnostic clue. Paraneoplastic, parainfectious, or idiopathic causes may occur. (Source: Neurology)

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Congenital varicella syndrome: A systematic review.

Sun, 13 Mar 2016 15:47:02 +0100

Authors: Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ Abstract Varicella-zoster virus (VZV) is a teratogen that can cross the placenta and cause the congenital varicella syndrome (CVS), which is characterised by multi-system anomalies. There have been 130 reported cases of CVS from 1947 to 2013. The estimated incidence of CVS was 0.59% and 0.84% for women infected with VZV during the entire pregnancy and for those infected the first 20 weeks of pregnancy, respectively. Nine cases were reported at 21-27 weeks of gestation and one case was identified at 36 weeks. Herpes zoster caused CVS in two cases. Regarding treatment, varicella zoster immunoglobulin treatment, irrespective of gestational age, should be considered in addition to antiviral drugs for women who have been e...

Positive Predictive Value of ICD-9 Code for Herpes Zoster Among Children During the Varicella Vaccine Era

Sat, 12 Mar 2016 19:07:26 +0100

We examined the positive predictive value of the herpes zoster ICD-9 diagnosis code 053 in the Kaiser Permanente Northwest integrated health plan. Among children 0–17 years old, the positive predictive value was 87.1% (95% confidence interval: 84.2–89.6) and 96.8% (95% confidence interval: 95.0–98.1) during the years 1997–2002 and 2005–2009, respectively, using chart review of the medical record as the diagnostic standard. (Source: The Pediatric Infectious Disease Journal)

Relationship between prior knowledge about herpes zoster and the period from onset of the eruption to consultation in patients with herpes zoster

Sat, 12 Mar 2016 00:00:00 +0100

Abstract Herpes zoster (HZ) is a common internal infection caused by latent varicella zoster virus. Emergence of antiviral chemotherapy has changed the treatment of HZ dramatically, but the effects of such therapy are documented only in patients who started treatment within 72 h of HZ onset of the eruption. There have been few studies addressing the question of factors that determine early attendance of patients at a clinic. We questioned 256 patients with acute HZ about: (i) date from onset of the eruption to first clinic visit; and (ii) their prior knowledge of HZ. We found a tendency that patients who already knew about HZ had consulted dermatology clinics earlier (P < 0.05). People most commonly obtained information about the disease from friends and family members who had previousl...

Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015.

Fri, 11 Mar 2016 14:54:02 +0100

Authors: Talley P, Holzbauer S, Smith K, Pomputius W Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. A rapid influenza assay was negative, and erythrocyte sedimentation rate and total white blood cell count were normal. She improved with symptomatic care at home, but returned to her pediatrician's office on April 28, reporting recurrence of her headache and photophobia and new onset of a stiff neck. She was admitted to the hospital, where she was febrile to 102.9°F (39.4°C) and had meningismus. Computed tomography scan of her head was normal, and a cerebrospinal fluid (CSF) analysis showed a markedly elevated white blood cell count with 68% lymphocytes, low glucose...

Field testing primary stabbing headache criteria according to the 3rd beta edition of International Classification of Headache Disorders: a clinic-based study

Fri, 11 Mar 2016 00:00:00 +0100

Conclusions All patients with headache with stabbing pain without cranial autonomic symptoms fulfilled the diagnostic criteria for PSH according to ICHD-3 beta at the initial visit. Secondary causes for headache with stabbing pain were revealed in a small proportion (3.7 %) of patients after 2 weeks of follow-up. (Source: The Journal of Headache and Pain)

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Novel therapeutic investigational strategies to treat severe and disseminated HSV infections suggested by a deeper understanding of in vitro virus entry processes.

Fri, 11 Mar 2016 00:00:00 +0100

Authors: Clementi N, Criscuolo E, Cappelletti F, Burioni R, Clementi M, Mancini N Abstract The global burden of herpes simplex virus (HSV) legitimates the critical need to develop new prevention strategies, such as drugs and vaccines that are able to fight either primary HSV infections or reactivations. Moreover, the ever-growing number of patients receiving transplants increases the number of severe HSV infections that are unresponsive to current therapies. Finally, the high global incidence of genital HSV-2 infection increases the risk of perinatal transmission to newborns, in which disseminated infection or central nervous system (CNS) involvement is frequent, with associated high morbidity and mortality rates. There are several key features shared by novel anti-HSV drugs, from ...

Physician Attitudes Toward Adult Vaccines and Other Preventive Practices, United States, 2012.

Thu, 10 Mar 2016 12:26:01 +0100

CONCLUSIONS: Despite lack of prioritization of vaccines by ACIP, physicians are prioritizing some vaccines over others and ranking some vaccines below other preventive services. These attitudes and confusion about the immunization schedule may result in missed opportunities for vaccination. Medicare preventive visits are not being used widely despite offering a venue for delivery of preventive services, including vaccinations. PMID: 26957667 [PubMed - in process] (Source: Public Health Reports)

Clinacanthus nutans: a review of the medicinal uses, pharmacology and phytochemistry

Thu, 10 Mar 2016 00:00:00 +0100

Publication date: Available online 10 March 2016 Source:Asian Pacific Journal of Tropical Medicine Author(s): Md. Ariful Alam, Sahena Ferdosh, Kashif Ghafoor, Md. Abdul Hakim, Abdul Shukor Juraimi, Alfi Khatib, Md. Zaidul I. Sarker Clinacanthus nutans Lindau is known as snake grass belonging to the Acanthaceae family. This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes, insects and snake bites, lesions caused by herpes simplex virus, diabetes, and gout in Malaysia, Indonesia, Thailand and China. Phytochemical investigations documented the varied contents of bioactive compounds from this plant namely flavonoids, glycosides, glycoglycerolipids, cerebrosides and monoacylmonogalatosylglycerol. The pharmacological experiment prove...

Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models

Thu, 10 Mar 2016 00:00:00 +0100

Authors: H Yang, T Peng, J Li, Y Wang, W Zhang, P Zhang, S Peng, T Du, Y Li, Q Yan & B Liu (Source: Gene Therapy)

A case of relapsing–remitting facial palsy and ipsilateral brachial plexopathy caused by HSV-1

Thu, 10 Mar 2016 00:00:00 +0100

Over the years, several explanations for Bell’s palsy (BP) have been given, but the etiology remains uncertain. The reason may be that there is no common etiological factor [1], but a common etiological pathogenesis. Both viral and autoimmune mechanisms have been suggested [2]. Herpes simplex virus type 1 (HSV-1) was postulated as the causative agent over 40 years ago [3], but direct evidence for HSV-1 infection in patients with BP is still lacking. Likewise, brachial plexus neuritis (BPN) is predominantly considered an autoimmune condition, but as with BP it rarely recurs [4]. (Source: Journal of Clinical Virology)

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Status of vaccine research and development of vaccines for herpes simplex virus prepared for WHO PD-VAC.

Thu, 10 Mar 2016 00:00:00 +0100

Authors: Johnston C, Gottlieb SL, Wald A Abstract Herpes simplex virus type-1 (HSV-1) and -2 (HSV-2) are highly prevalent global pathogens which commonly cause recurrent oral and genital ulcerations. Less common but more serious complications include meningitis, encephalitis, neonatal infection, and keratitis. HSV-2 infection is a significant driver of the HIV epidemic, increasing the risk of HIV acquisition 3 fold. As current control strategies for genital HSV-2 infection, including antiviral therapy and condom use, are only partially effective, vaccines will be required to reduce infection. Both preventive and therapeutic vaccines for HSV-2 are being pursued and are in various stages of development. We will provide an overview of efforts to develop HSV-2 vaccines, including a dis...

Novel analogs of alloferon: Synthesis, conformational studies, pro-apoptotic and antiviral activity.

Thu, 10 Mar 2016 00:00:00 +0100

In this study, we report the structure-activity relationships of novel derivatives of the insect peptide alloferon (H-His-Gly-Val-Ser-Gly-His-Gly-Gln-His-Gly-Val-His-Gly-OH). The peptide structure was modified by exchanging His at position 9 or 12 for natural or non-natural amino acids. Biological properties of these peptides were determined in antiviral in vitro test against Human Herpes Virus 1 McIntrie strain (HHV-1MC) using a Vero cell line. The peptides were also evaluated for the pro-apoptotic action in vivo on hemocytes of the Tenebrio molitor beetle. Additionally, the structural properties of alloferon analogs were examined by the circular dichroism in water and methanol. It was found that most of the evaluated peptides can reduce the HHV-1 titer in Vero cells. [Ala(9)]-alloferon e...

Herpes Vaccine Cuts Viral Shedding

Tue, 08 Mar 2016 21:53:51 +0100

(MedPage Today) -- Shedding down by as much as 55%, lesion count by 69% (Source: MedPage Today Public Health)

Randomized Trial Comparing Amniotic Membrane Transplantation with Lamellar Corneal Graft for the Treatment of Corneal Thinning

Tue, 08 Mar 2016 07:21:26 +0100

Conclusions: LCT proved to be the best option for treating corneal thinning. AMT represents an alternative that allows good visual recovery but does not restore corneal thickness as efficiently as LCT. (Source: Cornea)

Microbial Keratitis and Endophthalmitis After the Boston Type 1 Keratoprosthesis

Tue, 08 Mar 2016 07:21:26 +0100

Conclusions: Postoperative infections are a serious issue that compromises device retention and visual outcomes after keratoprosthesis implantation. (Source: Cornea)

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Evasion of host antiviral innate immunity by HSV-1, an update

Tue, 08 Mar 2016 00:00:00 +0100

Herpes simplex virus type 1 (HSV-1) infection triggers a rapid induction of host innate immune responses. The type I interferon (IFN) signal pathway is a central aspect of host defense which induces a wide ran... (Source: Virology Journal)

TLR9 stability and signaling are regulated by phosphorylation and cell stress.

Tue, 08 Mar 2016 00:00:00 +0100

Authors: Hasan M, Gruber E, Cameron J, Leifer CA Abstract Innate sensing of pathogens elicits protective immune responses through pattern recognition receptors, including Toll-like receptors. Although signaling by Toll-like receptors is regulated at multiple steps, including localization, trafficking, proteolytic cleavage, and phosphorylation, the significance of post-translational modifications and cellular stress response on Toll-like receptor stability and signaling is still largely unknown. In the present study, we investigated the role of cytoplasmic tyrosine motifs in Toll-like receptor-9 stability, proteolytic cleavage, and signaling. We demonstrated that tyrosine phosphorylation is essential for mouse Toll-like receptor-9 protein stability and signaling. Upon inhibition of ...

Effectiveness of hydrogen peroxide and electron-beam irradiation treatment for removal and inactivation of viruses in equine-derived xenografts.

Tue, 08 Mar 2016 00:00:00 +0100

This study assessed the efficacy of two steps applied in manufacturing some equine-derived xenografts: hydrogen-peroxide and e-beam sterilization treatments for inactivation and removal of viruses in equine bone granules (cortical and cancellous) and collagen and pericardium membranes. Viruses belonging to three different human viral species (Herpes simplex virus type 1, Coxsackievirus B1, and Influenzavirus type A H1N1) were selected and used to spike semi-processed biomaterials. For each viral species, the tissue culture infective dose (TCID50) on cell lines and the number of genome copies through qPCR were assessed. Both treatments were found to be effective at virus inactivation. Considering the model viruses studied, the application of hydrogen peroxide and e-beam irradiation could al...

Varicella zoster virus related deaths and hospitalizations in Brazil before the introduction of universal vaccination with the tetraviral vaccine.

Tue, 08 Mar 2016 00:00:00 +0100

CONCLUSIONS: Varicella is associated, in the pre-vaccine period, to significant morbidity and mortality in Brazil. The universal vaccination program is expected to decrease the disease burden from varicella. PMID: 26969400 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)

Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination

Mon, 07 Mar 2016 00:00:00 +0100

Epstein–Barr virus (EBV) infection is associated with increased multiple sclerosis (MS) risk. Recently, cytomegalovirus (CMV) infection has been proposed as a protective factor against MS development. We determined EBV, herpes simplex virus, varicella-zoster virus and CMV seroprevalence in 247 prospectively followed children with acquired demyelinating syndromes (ADS). Remote EBV infection was more common in children with MS than those with monophasic ADS while CMV infection was more common in children with monophasic ADS. Children displaying evidence of remote EBV without CMV infection were at highest risk of subsequent MS diagnosis. Viral infection repertoire detected at ADS provides important prognostic information. (Source: Multiple Sclerosis)

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Vaccine for treating genital herpes reduced viral shedding at 6 months

Sun, 06 Mar 2016 15:08:56 +0100

WASHINGTON – Research is honing in on the best dose for a therapeutic vaccine shown to reduce shedding of herpes simplex virus 2 in subjects with genital herpes infections, based on results presented... (Source: Internal Medicine News)

Investigational Therapeutic Genetic Herpes Vaccine PromisingInvestigational Therapeutic Genetic Herpes Vaccine Promising

Sun, 06 Mar 2016 09:07:57 +0100

Phase 2 data for a novel immunotherapy for genital herpes showed a significant reduction in viral shedding and lesions, although the reduction in lesions was also seen with placebo. Medscape Medical News (Source: Medscape Medical News Headlines)

Connexin32‑mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In vitro and in vivo anticancer activity.

Sun, 06 Mar 2016 05:15:02 +0100

Authors: Wu L, Zhou WB, Shen F, Liu W, Wu HW, Zhou SJ, Li SW Abstract Normal hepatocytes express connexin32 (Cx32), which forms gap junctions at cell‑cell contact areas. The aim of the present study was to investigate whether Cx32 mediates the cell death‑inducing effects of ultrasound microbubbles carrying the herpes simplex virus thymidine kinase (HSV‑TK) suicide gene against hepatocellular carcinoma cells in vitro and in vivo. HepG2 cells were exposed to different concentrations of trans‑retinoic acid (ATRA) in culture, to evaluate the intrinsic antitumor effect of ATRA. Detailed in‑vitro and in‑vivo investigations on the antitumor effects of ATRA via Cx32 mediation were performed, and the possible underlying mechanisms of action of the compound were then examined. ...

Lychee flower extract inhibits proliferation and viral replication of HSV-1-infected corneal epithelial cells.

Sun, 06 Mar 2016 02:52:01 +0100

CONCLUSIONS: These results showed the antiviral capabilities and the protective effects of LFE. Taken together, our data indicate that LFE has potential as an anti-HSK (herpes simplex keratitis) for HSV-1 infection. PMID: 26937165 [PubMed - in process] (Source: Molecular Vision)

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Investigational Therapeutic Genital Herpes Vaccine PromisingInvestigational Therapeutic Genital Herpes Vaccine Promising

Sun, 06 Mar 2016 02:43:49 +0100

Phase 2 data for a novel immunotherapy for genital herpes showed a significant reduction in viral shedding and lesions, although the reduction in lesions was also seen with placebo. Medscape Medical News (Source: Medscape Dermatology Headlines)

Initial Presentation of Neonatal Herpes Simplex Virus Infection

Sat, 05 Mar 2016 00:00:00 +0100

To inform the decision to test and empirically treat for herpes simplex virus (HSV) by describing the initial clinical presentation and laboratory findings of infants with a confirmed diagnosis of neonatal HSV. (Source: The Journal of Pediatrics)

Expert advises how to use shingles vaccine in rheumatology patients

Fri, 04 Mar 2016 12:50:44 +0100

MAUI, HAWAII – The herpes zoster vaccine is particularly important in patients with rheumatic diseases because their risks of shingles and postherpetic neuralgia are substantially higher than in the... (Source: Rheumatology News)

Wrestler with "mat herpes" virus wants state tournament postponed

Fri, 04 Mar 2016 01:26:55 +0100

High school wrestler believes he contracted highly contagious virus during a recent tournament in Northern California (Source: Health News:

Immunosuppressive medication use and risk of herpes zoster (HZ) in patients with systemic lupus erythematosus (SLE): A nationwide case-control study

Fri, 04 Mar 2016 00:00:00 +0100

The association between immunosuppressive medication use and herpes zoster (HZ) in patients with systemic lupus erythematosus (SLE) has not been clearly defined. (Source: Journal of the American Academy of Dermatology)

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Pathogenesis and life cycle of herpes simplex virus infection-stages of primary, latency and recurrence

Fri, 04 Mar 2016 00:00:00 +0100

Publication date: Available online 3 March 2016 Source:Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Sreeja P. Kumar, Marina Lazar Chandy, Muhammad Shanavas, Saba Khan, K.V. Suresh Aims and objectives (1) To understand the molecular level mechanism involved in immune evasion leading to primary HSV infection. (2) To explain the neuronal latency of herpes simplex virus. (3) To explain the reason for the specificity in the sites of primary and recurrent HSV lesions. Methods A systematic review was done to understand the molecular level mechanism involved in primary, latency and recurrent herpes simplex infections. We prepared this article by compiling the data from various textbooks, literatures and PubMed, Embase, and EBSCOhost databases. Results and ...

Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79.

Fri, 04 Mar 2016 00:00:00 +0100

Authors: Bowen CD, Renner DW, Shreve JT, Tafuri Y, Payne KM, Dix RD, Kinchington PR, Gatherer D, Szpara ML Abstract Herpes simplex virus 1 (HSV-1) is a widespread global pathogen, of which the strain KOS is one of the most extensively studied. Previous sequence studies revealed that KOS does not cluster with other strains of North American geographic origin, but instead clustered with Asian strains. We sequenced a historical isolate of the original KOS strain, called KOS63, along with a separately isolated strain attributed to the same source individual, termed KOS79. Genomic analyses revealed that KOS63 closely resembled other recently sequenced isolates of KOS and was of Asian origin, but that KOS79 was a genetically unrelated strain that clustered in genetic distance analyses wi...

Thymoma with immunodeficiency with multiple recurrent oral herpetic infections

Thu, 03 Mar 2016 00:00:00 +0100

Publication date: March 2016 Source:Journal of Dental Sciences, Volume 11, Issue 1 Author(s): Yavuz Sinan Aydintug, Gurkan Rasit Bayar, Aydin Ozkan, Omer Gunhan, Ugur Musabak Thymomas with immunodeficiency (formerly Good's syndrome) are a rare acquired disease of combined T- and B-cell immunodeficiency accompanying a thymoma. Recurrent opportunistic infections associated with disorders of both humoral and cell-mediated immunity frequently accompany this rare primary, adult-onset immunodeficiency. This is a report of a case of a thymoma with immunodeficiency in a 65-year-old male patient who developed recurrent oral herpetic infections. He consulted us about recurrent vesiculo-ulcerative lesions on his tongue, lower lip, and buccal mucosa. Results of laboratory examinations indicated...

Management of Ramsay Hunt syndrome among HIV patients: Our experience in a tertiary care hospital of eastern India

Thu, 03 Mar 2016 00:00:00 +0100

Conclusions Adequate awareness regarding early detection and management of RHS patients particularly among HIV positive cases is paramount among primary physicians. (Source: Polish Annals of Medicine)

Kyrieleis plaques associated with Herpes Simplex Virus type 1 acute retinal necrosis

Thu, 03 Mar 2016 00:00:00 +0100

We report the case of a 55 year old immunocompetent male who presented with features typical of acute retinal necrosis (ARN). Polymerase chain reaction of the aqueous tap was positive for Herpes Simplex Virus (HSV) -1. Following therapy with intravenous Acyclovir, followed by oral Acyclovir and steroids, there was marked improvement in the visual acuity and clinical picture. At one week after initiation of treatment, Kyrieleis plaques were observed in the retinal arteries. They became more prominent despite resolution of the vitritis, retinal necrosis and vasculitis and persisted till six weeks of follow up, when fluorescein angiography was performed. The appearance of this segmental retinal periarteritis also known as Kyrieleis plaques has not been described in ARN due to HSV-1 earlier. (...

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KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects. Case report and review of the literature

Thu, 03 Mar 2016 00:00:00 +0100

We report an asymptomatic HIV-negative female patient with incidentally found splenomegaly and extensive PET FDG-avid retroperitoneal, pelvic, and mediastinal lymphadenopathy. A core biopsy of her right pelvic lymph node showed aggregates of atypical cells with anaplastic features. Immunohistochemistry revealed that the neoplastic cells were positive for CD45, CD20, CD30, MUM1, CD138, EMA, CD3, HHV-8 and EBER. The diagnosis of ExPEL was established. Against medical advice and given the absence of significant symptoms, the patient refused to start treatment. Four months after the diagnosis, the patient remains asymptomatic, and follow-up CT scan demonstrates stability of her lymphadenopathy. We present here a case of ExPEL in which the patient's presentation defies the clinical norms, illus...

Vaccines for preventing herpes zoster in older adults.

Thu, 03 Mar 2016 00:00:00 +0100

CONCLUSIONS: Herpes zoster vaccine is effective in preventing herpes zoster disease and this protection can last three years. In general, zoster vaccine is well tolerated; it produces few systemic adverse events and injection site adverse events of mild to moderate intensity.There are studies of a new vaccine (with a VZV glycoproteic fraction plus adjuvant), which is currently not yet available for clinical use. PMID: 26937872 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)

Autophagy interaction with herpes simplex virus type-1 infection.

Wed, 02 Mar 2016 00:00:00 +0100

Authors: O'Connell D, Liang C Abstract More than 50% of the U.S. population is infected with herpes simplex virus type-I (HSV-1) and global infectious estimates are nearly 90%. HSV-1 is normally seen as a harmless virus but debilitating diseases can arise, including encephalitis and ocular diseases. HSV-1 is unique in that it can undermine host defenses and establish lifelong infection in neurons. Viral reactivation from latency may allow HSV-1 to lay siege to the brain (Herpes encephalitis). Recent advances maintain that HSV-1 proteins act to suppress and/or control the lysosome-dependent degradation pathway of macroautophagy (hereafter autophagy) and consequently, in neurons, may be coupled with the advancement of HSV-1-associated pathogenesis. Furthermore, increasing evidence su...

Monoclonals and Herpes Vaccine to Top Dermatology MeetingMonoclonals and Herpes Vaccine to Top Dermatology Meeting

Tue, 01 Mar 2016 20:24:07 +0100

New data on monoclonal antibodies for atopic dermatitis and phase 2 findings for a genital herpes vaccine will be among the most watched results from the American Academy of Dermatology meeting. Medscape Medical News (Source: Medscape Medical News Headlines)

The Incidence and Risk of Herpes Zoster in Patients With Sleep Disorders: A Population-Based Cohort Study

Tue, 01 Mar 2016 06:00:00 +0100

Abstract: Lack of sleep can compromise the immune system, which may reactivate latent varicella-zoster virus. Studies on sleep disorders and the risk of herpes zoster (HZ) are scant. We conducted a population-based cohort study to evaluate the risk of HZ in patients with sleep disorders and potential risk factors for HZ development. We identified patients with sleep disorders without apnea from 2002 to 2005 by using the Taiwan Longitudinal Health Insurance Database. The patients without sleep disorders were randomly selected and frequency matched with patients with sleep disorders according to age, sex, and index year. We estimated the follow-up time in person-years for the patients from the entry date until HZ diagnosis, loss to follow-up, or the end of 2010. We used Cox proportional ha...

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Risk of herpes zoster and family history: A Meta-analysis of case–control studies

Tue, 01 Mar 2016 00:00:00 +0100

Conclusions: This meta-analysis demonstrated that family history is a significant risk factor for HZ infection. This risk has a dose-response relationship with the number of relatives with a history of HZ. (Source: Indian Journal of Dermatology)

Pattern of dermatoses among nicobarese in a community health camp at Nancowry, Andaman and Nicobar Islands

Tue, 01 Mar 2016 00:00:00 +0100

Conclusion: The pattern of dermatoses seen among the Nicobarese is quite similar with respect to the prevalence of infections in other regions of India, especially humid regions such as Assam, coastal Karnataka, and Kolkata and much higher than arid regions such as the deserts of Rajasthan. (Source: Indian Journal of Dermatology)

The Cost-Effectiveness of Pregabalin Versus Gabapentin for Peripheral Neuropathic Pain (pNeP) and Postherpetic Neuralgia (PHN) in China

Tue, 01 Mar 2016 00:00:00 +0100

Conclusion Pregabalin is an effective treatment for PHN and even for pNeP extensively, but at increased cost. It leads to improved outcomes including lower pain scores and more days with no or mild pain. Funding Pfizer, China. (Source: Pain and Therapy)

Hospital-based herpes zoster diagnoses in Denmark: rate, patient characteristics, and all-cause mortality

Tue, 01 Mar 2016 00:00:00 +0100

Herpes zoster (HZ) may result in severe complications requiring hospital treatment, particularly in patients with comorbidity. Nevertheless, data on HZ from nationwide population-based hospital registries are ... (Source: BMC Infectious Diseases)

Universal varicella vaccine immunization in Japan.

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Yoshikawa T, Kawamura Y, Ohashi M Abstract In 1974, Japanese scientists developed a live attenuated varicella vaccine based on the Oka strain. The efficacy of the vaccine for the prevention of varicella has been primarily demonstrated in studies conducted in the United States following the adoption of universal immunization using the Oka strain varicella vaccine in 1996. Although the vaccine was developed by Japanese scientists, until recently, the vaccine has been administered on a voluntary basis in Japan resulting in a vaccine coverage rate of approximately 40%. Therefore, Japan initiated universal immunization using the Oka strain varicella vaccine in November 2014. Given the transition from voluntary to universal immunization in Japan, it will also be important to mon...

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Plasma IgG antibody against cytomegalovirus but not herpes simplex virus is associated with recurrence of atrial fibrillation after catheter ablation

Mon, 29 Feb 2016 00:00:00 +0100

This study sought to determine the role of viral pathogens, herpes simplex virus (HSV)-1, HSV-2, and cytomegalovirus (CMV), in AF recurrence after radiofrequency catheter ablation in a strictly selected patient population. A total of 4148 patients undergoing AF catheter ablation were screened for structural heart diseases and known risk factors for AF, and the resultant 103 patients (74 paroxysmal and 29 persistent) were recruited. Pre-ablation clinical and laboratory data and viral-specific IgG antibody levels were compared with those in 72 healthy control subjects. Plasma concentrations of the antibodies were all significantly elevated in AF patients (P < 0.001 vs. control). During a mean follow-up of 12.8 ± 7.0 months, 29 (28.2%) patients had AF recurrence. Patients who experi...

Topical cidofovir-induced acute kidney injury in two severely immunocompromised patients with refractory multidrug-resistant herpes simplex virus infections

Sat, 27 Feb 2016 00:00:00 +0100

We present two cases of multidrug-resistant herpes simplex virus infections that responded to topical cidofovir therapy yet resulted in irreversible acute kidney injury. (Source: Journal of Oncology Pharmacy Practice)

LGBT health and vaccinations: Findings from a community health survey of Lexington-Fayette County, Kentucky, USA.

Sat, 27 Feb 2016 00:00:00 +0100

This study reports the results of a 2012 Lexington-Fayette County, Kentucky, community health assessment's results asking about eight adult vaccinations among 218 lesbian, gay, bisexual, and transgendered (LGBT) respondents. Researchers collected data using an online survey distributed through LGBT social media, posters, and LGBT print media. The LGBT sample largely matches the demographics of the county as a whole except this group reports higher level of education and fewer uninsured individuals. Among LGBT respondents, immunization prevalence reaches 68.0% (annual Influenza), 65.7% (Hepatitis B), 58.8% (Chickenpox/Varicella), 55.9% (Hepatitis A), 41.2% (Smallpox), and 25.8% (Pneumonia). Among respondents who are currently within the recommended 19-26 years age range for the Human Papill...

VIDEO: Herpes gladiatorum may be misdiagnosed as impetigo

Fri, 26 Feb 2016 22:49:51 +0100

WAIKOLOA, HAWAII – Athletes who wrestle, play rugby, or engage in any sport “where there’s a grinding of skin on skin” are at risk for herpes simplex gladiatorum, according to Dr. Andrew Krakowski.... (Source: Pediatric News)

Federal judge approves consent decree with Florida dietary supplement distributor, Viruxo

Fri, 26 Feb 2016 20:48:00 +0100

A Florida dietary supplement distributor has been ordered by a federal court to stop selling its product, which it claimed could treat herpes. (Source: Food and Drug Administration)