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Preview: MedWorm: Glandular Fever (infectious mononucleosis)

MedWorm: Glandular Fever (infectious mononucleosis)



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Glandular Fever (infectious mononucleosis) category.



Last Build Date: Tue, 29 Mar 2016 16:33:05 +0100

 



Splenic infarction, a rare complication of infectious mononucleosis in a patient with no significant comorbidity: Case report and review of the literature

Tue, 29 Mar 2016 09:23:35 +0100

We report a case of a 32-y-old male diagnosed with infectious mononucleosis with splenomegaly complicated by splenic infarct in second week of illness documented by abdominal CT scan. (Source: International Journal of Infectious Diseases)

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Methylation of Epstein–Barr virus Rta promoter in EBV primary infection, reactivation and lymphoproliferation

Sun, 27 Mar 2016 22:00:00 +0100

During Epstein–Barr virus (EBV) latency, the EBV genome is largely silenced by methylation. This silencing is overturned during the switch to the lytic cycle. A key event is the production of the viral protein Zta which binds to three Zta‐response elements (ZRE) from the Rta promoter (Rp), two of which (ZRE2 and ZRE3) include three CpG motifs methylated in the latent genome. The bisulphite pyrosequencing reaction was used to quantify the methylation of ZRE2, ZRE3a, and ZRE3b in EBV‐positive cell lines and in ex vivo samples of EBV‐related diseases, in order to assess whether the level of methylation in these ZREs could provide additional information to viral DNA load and serology in the characterization of EBV‐associated diseases. In PBMC from two patients with infectious mononuc...



Population attributable fractions and joint effects of key risk factors for multiple sclerosis

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions: A high proportion of FCD onset can be explained by the currently known risk factors, with HLA-DR15, ever smoking and low cumulative sun exposure explaining most. We identified a significant interaction between HLA-DR15 and history of IM in predicting an FCD of CNS demyelination, which together with previous observations suggests that this is a true interaction. (Source: Multiple Sclerosis)



Methylation of Epstein Barr virus Rta promoter in EBV primary infection, reactivation and lymphoproliferation

Thu, 17 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)



Analysis of The Variability of Epstein-Barr Virus Genes in Infectious Mononucleosis: Investigation of the Potential Correlation with Biochemical Parameters of Hepatic Involvement / Analiza Genetičke Varijabilnosti Epštajn-Bar Virusa Kod Infektivne Mononukleoze: Ispitivanje Potencijalne Korelacije sa Biohemijskim Parametrima Infekcije Jetre

Thu, 10 Mar 2016 00:00:00 +0100

Authors: Banko, Ana / Lazarevic, Ivana / Stevanovic, Goran / Cirkovic, Andja / Karalic, Danijela / Cupic, Maja / Banko, Bojan / Milovanovic, Jovica / Jovanovic, Tanja (Source: Journal of Medical Biochemistry)



Red cell agglutination in infectious mononucleosis

Thu, 03 Mar 2016 00:00:00 +0100

(Source: Blood)

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Viruses, Vol. 8, Pages 60: From Conventional to Next Generation Sequencing of Epstein-Barr Virus Genomes

Wed, 24 Feb 2016 00:00:00 +0100

Genomic sequences of Epstein–Barr virus (EBV) have been of interest because the virus is associated with cancers, such as nasopharyngeal carcinoma, and conditions such as infectious mononucleosis. The progress of whole-genome EBV sequencing has been limited by the inefficiency and cost of the first-generation sequencing technology. With the advancement of next-generation sequencing (NGS) and target enrichment strategies, increasing number of EBV genomes has been published. These genomes were sequenced using different approaches, either with or without EBV DNA enrichment. This review provides an overview of the EBV genomes published to date, and a description of the sequencing technology and bioinformatic analyses employed in generating these sequences. We further explored ways through wh...



Cytomegalovirus Appendicitis in an Immunocompetent Host

Sat, 20 Feb 2016 00:00:00 +0100

Cytomegalovirus (CMV) is a common viral pathogen. Asymptomatic infection or a mononucleosis syndrome are the most common manifestations in otherwise healthy individuals. End-organ disease is rare in immunocompetent individuals. Here, we describe a case of CMV appendicitis in a patient without an immune-compromising condition. (Source: Journal of Clinical Virology)



Post Allo-Transplant Epstein-Bar Virus (EBV) Infection of Donor Engrafted Cells May Mimic Relapse of the Primary Disease (Leukemia/Lymphoma)

Fri, 19 Feb 2016 10:35:21 +0100

We report two cases wherein pediatric patients, presented with benign lymphoproliferative disease concerning for relapse more than one year after umbilical cord blood stem cell transplantation(UCBSCT) while on no immunosuppression. (Source: Biology of Blood and Marrow Transplantation)



IgG Subclasses and Isotypes of VH4-34 Encoded Antibodies.

Wed, 17 Feb 2016 14:24:02 +0100

Authors: Bhat NM, Kshirsagar MA, Bieber MM, Teng NN Abstract VH4-34 gene encoded autoantibodies are elevated in systemic lupus erythematosus (SLE) and in other diseases associated with B-cell hyperproliferation/dysfunction. One of the autoantigens recognized by VH4-34-encoded antibodies are branched/linear poly N-acetyl lactosamine chains. Since the anti-carbohydrate response in humans is dominated by the IgG2 subclass, here we tested whether VH4-34 encoded IgG showed similar subclass segregation. Serum samples from SLE, infectious mononucleosis, nasopharyngeal carcinoma and hepatitis-C were analyzed. Levels of VH4-34-encoded IgM and IgA isotypes were also tested. VH4-34-IgM and IgA were elevated in all four clinical conditions. VH4-34-IgG was detected in the IgG1 and IgG3 subclass...



Kinetics of Epstein-Barr Virus (EBV) Neutralizing and Virus-Specific Antibodies after Primary Infection with EBV.

Wed, 17 Feb 2016 00:00:00 +0100

Authors: Bu W, Hayes GM, Liu H, Gemmell L, Schmeling DO, Radecki P, Aguilar F, Burbelo PD, Woo J, Balfour HH, Cohen JI Abstract Prospective studies of antibodies to multiple Epstein-Barr virus (EBV) proteins and EBV neutralizing antibodies in the same individuals before, during, and after primary EBV infection have not been reported. We studied antibody responses to EBV in college students who acquired primary EBV infection during prospective surveillance and correlated kinetics of antibody response with severity of disease. Neutralizing antibodies and ELISA antibodies to gp350, the major target of neutralizing antibody, reached peak levels a median of 179 and 333 days after onset of symptoms of infectious mononucleosis, respectively. No clear correlation was found between severity...

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Clinical practice guideline: tonsillitis II. Surgical management

Tue, 16 Feb 2016 00:00:00 +0100

Conclusions concerning the efficacy of TE on the number of sore throat episodes per year are limited to 12 postoperative months in children and 5–6 months in adults. The impact of TE on the number of sore throat episodes per year in children is modest. Due to the heterogeneity of data, no firm conclusions on the effectiveness of TE in adults can be drawn. There is still an urgent need for further research to reliably estimate the value of TE compared to non-surgical therapy of tonsillitis/tonsillo-pharyngitis. The impact of TE on quality of life is considered as being positive, but further research is mandatory to establish appropriate inventories and standardized evaluation procedures, especially in children. In contrast to TE, TT or comparable procedures are characterized by a substan...



Viruses, Vol. 8, Pages 51: Infectious Mononucleosis Triggers Generation of IgG Auto-Antibodies against Native Myelin Oligodendrocyte Glycoprotein

Fri, 12 Feb 2016 00:00:00 +0100

A history of infectious mononucleosis (IM), symptomatic primary infection with the Epstein Barr virus, is associated with the development of autoimmune diseases and increases the risk to develop multiple sclerosis. Here, we hypothesized that immune activation during IM triggers autoreactive immune responses. Antibody responses towards cellular antigens using a HEp-2 based indirect immunofluorescence assay and native myelin oligodendrocyte glycoprotein (MOG) using a flow cytometry-based assay were determined in 35 patients with IM and in 23 control subjects. We detected frequent immunoglobulin M (IgM) reactivity to vimentin, a major constituent of the intermediate filament family of proteins, in IM patients (27/35; 77%) but rarely in control subjects (2/23; 9%). IgG autoantibodies binding t...



Transient seizure‐related MRI abnormalities in a child with primary Epstein–Barr virus infection

Thu, 04 Feb 2016 00:00:00 +0100

We describe the case of a 6‐year‐old girl with typical infectious mononucleosis syndrome complicated by clustered right hemiconvulsions and disturbed consciousness. Diffusion‐weighted magnetic resonance imaging on admission demonstrated reduced diffusion in the left temporo‐posterior cortex and pulvinar of the ipsilateral thalamus. Her neurological symptoms resolved completely by the next day, with complete disappearance of abnormal signal intensities on magnetic resonance imaging (MRI). Elevated cerebrospinal fluid interleukin (IL)‐6 with normal IL‐10 might indicate a neuroprotective role of IL‐6 rather than injury. We concluded that the MRI abnormalities could have been due to the seizure activity itself rather than Epstein–Barr virus‐associated encephalitis. The recogn...



[A Case of Severe Chronic Active Epstein-Barr Virus Infection with Aplastic Anemia and Hepatitis].

Mon, 25 Jan 2016 00:00:00 +0100

Authors: Lee JI, Lee SW, Han NI, Ro SM, Noh YS, Jang JW, Bae SH, Choi JY, Yoon SK Abstract Epstein-Barr virus (EBV) causes various acute and chronic diseases. Chronic active EBV infection (CAEBV) is characterized by infectious mononucleosis-like symptoms that persist for more than 6 months with high viral loads in peripheral blood and/or an unusual pattern of anti-EBV antibodies. Severe CAEBV is associated with poor prognosis with severe symptoms, an extremely high EBV-related antibody titer, and hematologic complications that often include hemophagocytic lymphohistiocytosis. However, CAEBV which led to the development of aplastic anemia (AA) has not been reported yet. A 73-year-old woman was admitted to our hospital with intermittent fever, general weakness and elevated liver enzy...



Infectious mononucleosis, other infections and prostate‐specific antigen concentration as a marker of prostate involvement during infection

Thu, 21 Jan 2016 00:00:00 +0100

Although Epstein‐Barr virus has been detected in prostate tissue, no associations have been observed with prostate cancer in the few studies conducted to date. One possible reason for these null findings may be use of cumulative exposure measures that do not inform the timing of infection, i.e., childhood versus adolescence/early adulthood when infection is more likely to manifest as infectious mononucleosis (IM). We sought to determine the influence of young adult‐onset IM on the prostate by measuring prostate‐specific antigen (PSA) as a marker of prostate inflammation/damage among U.S. military members. We defined IM cases as men diagnosed with IM from 1998 to 2003 (n = 55) and controls as men without an IM diagnosis (n = 255). We selected two archived serum specimens for e...

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Epstein-Barr virus encephalitis with substantia nigra involvement

Wed, 20 Jan 2016 00:00:00 +0100

Tamer Celik, Umit Celik, Orkun Tolunay, Mustafa Komur, Huseyin Baspinar, Cengiz Yilmaz, Gulen Mert, Dincer YildizdasJournal of Pediatric Neurosciences 2015 10(4):401-403Infectious mononucleosis due to Epstein–Barr virus (EBV) is a usually benign systemic viral illness common in children. Many studies described nervous system manifestations of infectious mononucleosis with a wide spectrum of neurologic deficits. Neurologic complications of EBV are seen in both acute and reactivate infection. Herein, we describe a patient diagnosed by acute EBV encephalitis with substantia nigra involvement and excellent clinical recovery. (Source: Journal of Pediatric Neurosciences)



Atypical manifestations of Epstein-Barr virus in children: a diagnostic challenge.

Wed, 20 Jan 2016 00:00:00 +0100

CONCLUSIONS: Physicians should be cautious about uncommon presentations of the viral infection and consider EBV as a causative agent when they encounter similar clinical pictures. PMID: 26802473 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)



Horner syndrome in glandular fever: a case report.

Fri, 15 Jan 2016 09:35:04 +0100

CONCLUSION: This is the first report in the worldwide literature of Horner syndrome arising as a result of compression from enlarged lymph nodes in glandular fever. PMID: 26732343 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)



Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism.

Tue, 12 Jan 2016 06:45:02 +0100

Authors: Poh SS, Chua ML, Wee JT Abstract Current proposed mechanisms implicate both early and latent Epstein-Barr virus (EBV) infection in the carcinogenic cascade, whereas epidemiological studies have always associated nasopharyngeal carcinoma (NPC) with early childhood EBV infection and with chronic ear, nose, and sinus conditions. Moreover, most patients with NPC present with IgA antibody titers to EBV capsid antigen (VCA-IgA), which can precede actual tumor presentation by several years. If early childhood EBV infection indeed constitutes a key event in NPC carcinogenesis, one would have to explain the inability to detect the virus in normal nasopharyngeal epithelium of patients at a high risk for EBV infection. It is perhaps possible that EBV resides within the salivary gland...



Syncope in an Athlete: a Case of Infectious Mononucleosis-Induced Postural Tachycardia Syndrome

Fri, 01 Jan 2016 06:00:00 +0100

No abstract available (Source: Current Sports Medicine Reports)

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Syncope in an Athlete: a Case of Infectious Mononucleosis-Induced Postural Tachycardia Syndrome.

Fri, 01 Jan 2016 00:00:00 +0100

Authors: Pohlgeers KM, Stumbo JR PMID: 26745170 [PubMed - in process] (Source: Current Sports Medicine Reports)



Researchers at Howard Hughes Medical Institute Develop Blood Test That Reveals a Patient’s Viral History; Could Reduce Unnecessary Clinical Laboratory Testing

Wed, 30 Dec 2015 11:03:06 +0100

The VirScan test gives doctors insight into a patient’s lifetime exposure to viruses and thus may be developed into a useful medical laboratory test Scientists and pathologists are learning that blood is like a time capsule, holding precious information about exposure to viruses over the years—chickenpox at five, mononucleosis at 18, flu at 40. You […] (Source: Dark Daily)



Ulcus vulvae acutum — A case of genital ulcers in adolescent girl

Tue, 29 Dec 2015 00:00:00 +0100

We describe a case of adolescent female with an episode of ulcus vulvae acutum associated with infectious mononucleosis. The diagnosis was supported by the clinical symptoms, elevated circulating levels of liver enzymes, positive EBV serology, cervical and inguinal lymphadenomegaly, and hepatosplenomegaly. The patient presented a history of aphthous stomatitis. Negative Pathergy test and the absence of any other related symptoms allowed us to exclude the Behçhet syndrome. Lesions healed with no sequelae or recurrences. (Source: Case Reports in Womens Health)



An adolescent evaluated for chronic fatigue: does she have a sleep disorder?

Sun, 20 Dec 2015 23:44:52 +0100

Authors: Gonzalez M, Fisher M Abstract A 13-year-old girl presented to our Division of Adolescent Medicine for evaluation of ongoing fatigue. She and her mother reported that 15 months earlier, when the patient was in the 7th grade, she started to be tired and "sleep all the time." They do not remember her being ill at that time; a test for mononucleosis was reportedly positive, but Epstein-Barr virus titers showed "old disease." She remained fatigued throughout 7th grade but attended school without falling asleep; however, she was too tired to do her work and had to attend summer school. The patient received home instruction in 8th grade and reported that on weekdays she slept from 1 AM to 11 AM with a nap from 4 to 8 PM and on weekends she slept from 3 AM to 1 PM without a nap. ...



When to consider acute HIV infection in the differential diagnosis

Fri, 18 Dec 2015 19:05:46 +0100

This article describes when to order HIV testing and discusses the importance of early intervention for acute HIV infection. (Source: The Nurse Practitioner)

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Infectious Mononucleosis, Other Infections, and Prostate‐Specific Antigen Concentration as a Marker of Prostate Involvement During Infection

Fri, 18 Dec 2015 12:57:12 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



Level of education and multiple sclerosis risk after adjustment for known risk factors: The EnvIMS study

Fri, 18 Dec 2015 00:00:00 +0100

Conclusion: These findings suggest that factors related to lower socioeconomic status other than established risk factors are associated with MS risk. (Source: Multiple Sclerosis)



Infectious Mononucleosis Complicated with Acute Cerebral Infarction: A Case Report.

Sat, 12 Dec 2015 20:53:12 +0100

CONCLUSION: Although IM is known to be self-limited, it could contribute to acute cerebral infarction, which is a rare IM neurological complication. PMID: 26179687 [PubMed - in process] (Source: Acta Neurologica Taiwanica)



Ulcus vulvae acutum – a case of genital ulcers in adolescent girl

Sat, 12 Dec 2015 00:00:00 +0100

We describe a case of adolescent female with an episode of ulcus vulvae acutum associated with infectious mononucleosis. The diagnosis was supported by the clinical symptoms, elevated circulating levels of liver enzymes, positive EBV serology, cervical and inguinal lymphadenomegaly, hepatosplenomegaly. The patient presented a history of aphthous stomatitis. Negative Pathergy test and the absence of any other related symptoms allowed us to exclude the Behçhet syndrome. Lesions healed with no sequelae or recurrences. (Source: Case Reports in Womens Health)



Fever, Dry Cough and Exertional Dyspnea: Pulmonary Lymphomatoid Granulomatosis Masquerading as Pneumonia, Granulomatosis with Polyangiitis and Infectious Mononucleosis.

Sun, 06 Dec 2015 14:48:03 +0100

We report the case of a 39-year-old man with pulmonary LYG who presented to a hospital after experiencing three months of fever, weight loss, dry cough and exertional dyspnea. He was initially misdiagnosed with pneumonia, granulomatosis with polyangiitis and infectious mononucleosis due to the non-specific manifestations of the disease. We herein present the clinical and radiological characteristics of this case and discuss the procedure for pathological diagnosis, which will likely help clinicians in making a timely definitive diagnosis of this disease. PMID: 26631890 [PubMed - in process] (Source: Internal Medicine)

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Mononucleosis: Can it recur?

Wed, 02 Dec 2015 00:00:00 +0100

(Source: MayoClinic.com - Ask a Specialist)



My Open Letter to Lyme Disease

Mon, 30 Nov 2015 00:22:31 +0100

Dear Lyme disease, I'm not angry. But I admit you made me miserable. You sneakily rushed through my veins. Anonymous, without a name, you tortured me for months. I didn't know who you were or where you came from. I would stare bleakly out my freshman dorm window, my eyes dull and my head throbbing. I blamed my school. During my first quarter at Northwestern University, my boyfriend and I broke up, my grandfather died, and I couldn't get out of bed for my morning classes. I reluctantly dropped a course after meeting with an adviser who thought I was struggling to acclimate to college. I was 850 miles from home and started to believe that I never should have left the East Coast. But Northwestern was the pennant on my corkboard at home; it was the sweatshirt my dad wore proudly to our local ...



[Acute dacryocystitis and infectious mononucleosis: An association not to be missed].

Sat, 28 Nov 2015 12:51:34 +0100

Authors: Martin G, Pon A, Robert M, Aymard PA, Reynaud C, Michel S, Roche O PMID: 26563841 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)

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NOWDx Focuses on On-Site Diagnosis

Mon, 23 Nov 2015 06:00:00 +0100

Just inside the front door of NOWDiagnostics is a dog bed with a chew toy that is roughly the size of an elephant femur. The owner of the chew toy bounds up to visitors: Annie, an overtly cheerful 7-month-old Irish wolfhound who belongs to NOWDiagnostics CEO Kevin Clark. Annie, after being petted partially in self-defense, soon lopes off through the office complex to make her rounds at the Springdale facility. Don’t mistake the casualness of the greeting for a lack of seriousness at NOWDiagnostics. Clark and his staff of mostly Ph.D.-credentialed researchers are doing serious and potentially lifesaving work. “I personally think this can save the health care industry billions of dollars,” Clark said. “It empowers people to make the right decision sooner, getting resu...



Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus-Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation

Mon, 23 Nov 2015 00:00:00 +0100

Acute infectious mononucleosis (IM) is associated with altered expression of inflammatory cytokines and disturbed T-cell homeostasis, however, the precise mechanism of this immune dysregulation remains unresolved. In the current study we demonstrated a significant loss of circulating myeloid and plasmacytoid dendritic cells (DCs) during acute IM, a loss correlated with the severity of clinical symptoms. In vitro exposure of blood DCs to acute IM plasma resulted in loss of plasmacytoid DCs, and further studies with individual cytokines showed that exposure to interleukin 10 could replicate this effect. Our data provide important mechanistic insight into dysregulated immune homeostasis during acute IM. (Source: The Journal of Infectious Diseases)



Steroids for symptom control in infectious mononucleosis.

Sun, 08 Nov 2015 00:00:00 +0100

CONCLUSIONS: There is insufficient evidence to the efficacy of steroids for symptom control in infectious mononucleosis. There is a lack of research on the side effects and long-term complications. PMID: 26558642 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)



Hodgkins in U.S. Servicemen

Mon, 02 Nov 2015 00:00:00 +0100

Conclusions: Protection from the environment in childhood, but not in adulthood, increases the likelihood of young adult Hodgkin lymphoma, which may result from nonspecific isolation from early infections and/or exposure to late infection by a specific but unidentified ubiquitous childhood virus. Impact: Events in childhood protect against later Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev; 24(11); 1707–15. ©2015 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)



Higher Frequency of CD4+CXCR5+ICOS+PD1+ T Follicular Helper Cells in Patients With Infectious Mononucleosis

Sun, 01 Nov 2015 05:00:00 +0100

In this study, we found that the CD4+CXCR5+ Tfh cells were not significantly changed, but the CD4+CXCR5+ICOS+ and CD4+CXCR5+ICOS+PD1+ Tfh subsets were significantly increased in the IM patients, and all these cells were significantly changed after antiviral therapy. Second, only the numbers of CD4+CXCR5+ICOS+PD1+ Tfh cells correlated with the Epstein-Barr virus (EBV) DNA load, negatively correlated with the numbers of naive B cells and amount of IL-21, and positively correlated with the numbers of plasma cells, memory B cells, and atypical lymphocytes. Third, the frequency of CD4+CXCR5+ICOS+PD1+ Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase (ALT). All together, our findings discovered this C...

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Splenic rupture in infectious mononucleosis: A systematic review of published case reports

Sat, 31 Oct 2015 00:00:00 +0100

:Infectious mononucleosis (IM) is a common viral illness that predominantly causes sore throat, fever and cervical lymphadenopathy in adolescents and young adults. Although usually a benign, self-limiting disease, it is associated with a small risk of splenic rupture, which can be life-threatening. It is common practice therefore to advise avoiding vigorous physical activity for at least 4-6 weeks, however this is not based on controlled trials or national guidelines. We reviewed published case reports of splenic rupture occurring in the context of IM in an attempt to ascertain common factors that may predict who is at risk. (Source: Injury)



A hospital based pilot study on Epstein-Barr virus in suspected infectious mononucleosis pediatric patients in India

Thu, 29 Oct 2015 07:00:00 +0100

Conclusions: VCA PCR is sensitive for the detection of EBV DNA in the early or primary stage of infection and can be considered a reliable method to rule out the cross-reactivity and differential diagnosis of EBV-induced IM from IM-like syndrome. (Source: The Journal of Infection in Developing Countries)



Splenic Infarction in Acute Infectious Mononucleosis

Thu, 22 Oct 2015 00:00:00 +0100

The evaluation of a febrile patient with acute abdominal pain represents a frequent yet possibly challenging situation in the emergency department (ED). Splenic infarction is an uncommon complication of infectious mononucleosis, and may have a wide range of clinical presentations, from dramatic to more subtle. Its pathogenesis is still incompletely understood, yet it may be associated with the occurrence of transient prothrombotic factors. (Source: The Journal of Emergency Medicine)



Does low socioeconomic status in early life protect against multiple sclerosis? A multinational, case–control study

Sun, 18 Oct 2015 05:24:38 +0100

ConclusionThere is no consistent association between parental SES and MS risk in Norway, Canada and Italy, with a protective effect of low SES only found in Canada. (Source: European Journal of Neurology)

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Identification of the critical attribute(s) of EBV gp350 antigen required for elicitation of a neutralizing antibody response in vivo.

Sat, 17 Oct 2015 00:00:00 +0100

Authors: Servat E, Ro BW, Cayatte C, Gemmell L, Barton C, Rao E, Lin R, Zuo F, Woo JC, Hayes GM Abstract Vaccine prophylaxis with EBV glycoprotein 350 (gp350) subunit plus adjuvant has been demonstrated clinically to protect individuals against infectious mononucleosis (IM), but the specifications of the antigen required to elicit this protection has remained largely theoretical. Previous studies have shown that antibodies to gp350 comprise the principle component of EBV-neutralizing sera. Further, a murine monoclonal antibody against gp350 (clone 72A1) is able to prevent infection by the virus both in vitro and in vivo. In the present study, we identify the 72A1 epitope on recombinant gp350 antigen as the site required for binding to CD21 on human B cells. We also identify the nee...



Season of glandular fever as a risk factor for multiple sclerosis

Wed, 14 Oct 2015 00:00:00 +0100

Conclusions Glandular fever in winter as opposed to summer does not appear to be associated with a greater risk of developing MS. (Source: Journal of Neurology, Neurosurgery and Psychiatry)



Real‐time polymerase chain reaction for diagnosing infectious mononucleosis in pediatric patients: A systematic review and meta‐analysis

Mon, 12 Oct 2015 15:35:24 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)



Immune response induced by Epstein–Barr virus and Mycobacterium avium subsp. paratuberculosis peptides in current and past infectious mononucleosis: a risk for multiple sclerosis?

Sat, 10 Oct 2015 22:41:27 +0100

ConclusionOur results highlight that EBV and MAP may be involved independently in the same causal process leading to MS in subjects with a history of IM. (Source: European Journal of Neurology)



Coeliac disease and Hodgkin lymphoma: Casual or cause–effect relationship?

Thu, 08 Oct 2015 00:00:00 +0100

We report a case of a 16 year old female patient, premature, natural childbirth. Neonatal period and weaning were normal. The patient's past medical history was unremarkable except for an infectious mononucleosis at 15 year One year before the medical examination in our clinic, the girl complained about persistent high fever, diffused arthralgia, cutaneous rash, night sweating and systemic lymphadenitis. Hodgkin lymphoma was diagnosed at pediatric hematology and chemotherapy and radiotherapy were administered. (Source: Digestive and Liver Disease)

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Case report: a diagnostically challenging conjunctival mass caused by the Epstein-Barr virus

Wed, 07 Oct 2015 00:00:00 +0100

We present a paediatric case of infectious mononucleosis in a 13-year old, manifesting with follicular conjunctivitis and a conjunctival mass in one eye with no evidence of leucocytosis on the blood count. The diagnosis was confirmed following surgical excision and biopsy. The case represented a diagnostic challenge due to its atypism and given the steady increase in the prevalence of EBV-related ocular diseases in the last years, this report can serve as an example to prompt earlier serological tests to identify the aetiology in similar cases. This is important because EBV can be treated with acyclovir early in the active viral phase. (Source: BMC Ophthalmology)



Smoking an MS Risk Factor Among MS Patients' Relatives (CME/CE)

Sun, 04 Oct 2015 16:35:01 +0100

(MedPage Today) -- But no link found to history of infectious mononucleosis (Source: MedPage Today Meeting Coverage)



Primary Immunodeficiencies Associated with EBV Disease.

Sat, 03 Oct 2015 10:06:03 +0100

Authors: Cohen JI Abstract Epstein-Barr virus (EBV) infects nearly all humans and usually is asymptomatic, or in the case of adolescents and young adults, it can result in infectious mononucleosis. EBV-infected B cells are controlled primarily by NK cells, iNKT cells, CD4 T cells, and CD8 T cells. While mutations in proteins important for B cell function can affect EBV infection of these cells, these mutations do not result in severe EBV infection. Some genetic disorders affecting T and NK cell function result in failure to control EBV infection, but do not result in increased susceptibility to other virus infections. These include mutations in SH2D1A, BIRC4, ITK, CD27, MAGT1, CORO1A, and LRBA. Since EBV is the only virus that induces proliferation of B cells, the study of these d...



Infectious Mononucleosis.

Sat, 03 Oct 2015 10:06:03 +0100

Authors: Dunmire SK, Hogquist KA, Balfour HH Abstract Infectious mononucleosis is a clinical entity characterized by sore throat, cervical lymph node enlargement, fatigue, and fever most often seen in adolescents and young adults and lasting several weeks. It can be caused by a number of pathogens, but this chapter only discusses infectious mononucleosis due to primary Epstein-Barr virus (EBV) infection. EBV is a γ-herpesvirus that infects at least 90 % of the population worldwide. The virus is spread by intimate oral contact among teenagers and young adults. How preadolescents acquire the virus is not known. A typical clinical picture with a positive heterophile test is usually sufficient to make the diagnosis, but heterophile antibodies are not specific and do not develop in so...



The Biology and Clinical Utility of EBV Monitoring in Blood.

Sat, 03 Oct 2015 10:06:03 +0100

Authors: Kanakry J, Ambinder R Abstract Epstein-Barr virus (EBV) DNA in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (CCF) DNA specimens, or in whole blood. CCF viral DNA may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. In infectious mononucleosis, viral DNA is detected in each of these kinds of specimens, although it is only transiently detected in CCF specimens. In nasopharyngeal carcinoma, CCF EBV DNA is an established tumor marker. In EBV-associated Hodgkin lymphoma and in EBV-associated extranodal NK-/T-cell lymphoma, there is growing evidence for the utility of CCF DNA as a tumor marker. PMID: 26428386 [PubMed - in process] (Source: Curren...

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EBV-Specific Immune Response: Early Research and Personal Reminiscences.

Sat, 03 Oct 2015 10:06:03 +0100

Authors: Moss DJ, Lutzky VP Abstract Early research on Epstein-Barr virus (EBV) developed from serological observations that were made soon after the discovery of the virus. Indeed, the definition of the humoral response to a variety of EBV proteins dominated the early literature and was instrumental in providing the key evidence for the association of the virus with infectious mononucleosis (IM), Burkitt's lymphoma (BL), and nasopharyngeal carcinoma (NPC). Each of these disease associations involved a distinct pattern of serological reactivity to the EBV membrane antigens (MA), early antigens (EA), and the EBV nuclear antigen (EBNA). When it became generally accepted that the marked lymphocytosis , which is a hallmark of acute IM, was dominated by T cells, considerable effort was ...



The Development of Prophylactic and Therapeutic EBV Vaccines.

Sat, 03 Oct 2015 10:06:03 +0100

Authors: Smith C, Khanna R Abstract Over the last century, the development of effective vaccine approaches to treat a number of viral infections has provided the impetus for the continual development of vaccine platforms for other viral infections, including Epstein-Barr virus (EBV). The clinical manifestations associated with EBV infection occur either following primary infection, such as infectious mononucleosis, or following an extended period of latency, primarily the EBV-associated malignancies and potentially including a number of autoimmune disorders, such as multiple sclerosis. As a consequence, two independent vaccine approaches are under development to prevent or control EBV-associated diseases. The first approach, which has been widely successful against other viral infe...



Profiling of EBV-Encoded microRNAs in EBV-Associated Hemophagocytic Lymphohistiocytosis.

Fri, 02 Oct 2015 12:08:05 +0100

Authors: Zhou C, Xie Z, Gao L, Liu C, Ai J, Zhang L, Shen K Abstract Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening complication of EBV infection. MicroRNAs (miRNAs) were small non-coding RNA, and EBV could encode miRNAs that are involved in the progression of infection. However, the profiles of EBV-miRNAs in EBV-HLH were unknown. Here, we aimed to profile the expression of EBV-miRNAs in children with EBV-HLH by analyzing 44 known EBV-miRNAs, encoded within the BamHI fragment H rightward open reading frame 1 (BHRF1) and the BamHI-A region rightward transcript (BART), in plasma and cellular targets by real-time quantitative PCR. The study included 15 children with EBV-HLH, 15 children with infectious mononucleosis (IM), and 15 health...






Primary immunodeficiencies and the control of Epstein–Barr virus infection

Mon, 28 Sep 2015 00:00:00 +0100

Human primary immunodeficiency (PID) states, where mutations in single immune system genes predispose individuals to certain infectious agents and not others, are experiments of nature that hold important lessons for the immunologist. The number of genetically defined PIDs is rising rapidly, as is the opportunity to learn from them. Epstein–Barr virus (EBV), a human herpesvirus, has long been of interest because of its complex interaction with the immune system. Thus, it causes both infectious mononucleosis (IM), an immunopathologic disease associated with exaggerated host responses, and at least one malignancy, EBV‐positive lymphoproliferative disease, when those responses are impaired. Here, we describe the full range of PIDs currently linked with an increased risk of EBV‐associate...

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Cholestatic Hepatitis Induced by Epstein-Barr Virus in a Pediatric Population

Wed, 09 Sep 2015 00:00:00 +0100

Conclusion. EBV infection should be included in the differential diagnosis of CH in all age groups. In the vast majority, full recovery is expected. (Source: Clinical Pediatrics)



Hepatosplenic T-Cell Lymphoma: A Clinicopathologic Review With an Emphasis on Diagnostic Differentiation From Other T-Cell/Natural Killer-Cell Neoplasms.

Tue, 01 Sep 2015 00:00:00 +0100

Authors: Shi Y, Wang E Abstract Hepatosplenic T-cell lymphoma is a rare, aggressive T-cell lymphoma, characterized by hepatosplenic sinusoidal infiltration of monotonous, medium-sized, nonactivated cytotoxic T cells, usually of γ/δ T-cell receptor type. Hepatosplenic T-cell lymphoma occurs more frequently in immunocompromised patients, especially in those receiving long-term immunosuppressive therapy. Patients usually manifest hepatosplenomegaly without lymphadenopathy. The bone marrow is also involved in two-thirds of cases and is often accompanied by circulating lymphoma cells, which, along with anemia and thrombocytopenia, may raise suspicion for acute leukemia. The differential diagnosis includes aggressive natural killer-cell leukemia, T-large granular lymphocytic leukemia, ...



Early virological and immunological events in Epstein–Barr virus infection

Tue, 01 Sep 2015 00:00:00 +0100

Publication date: December 2015 Source:Current Opinion in Virology, Volume 15 Author(s): Andrew D Hislop Epstein–Barr virus (EBV) is a γ-herpesvirus which establishes a chronic yet asymptomatic infection in humans. This saliva transmitted virus has a tropism for B lymphocytes, in which it establishes a latent infection, and epithelial cells where the virus replicates to produce infectious particles. Although the majority of infections are apparently benign, primary EBV infection can be associated with an acute febrile syndrome, infectious mononucleosis, while infection is also associated with the development of malignancies of B lymphocyte and epithelial origin. A better understanding how the virus replicates initially in the host and its control at this stage will lead to the develo...



Common Immune-Related Exposures/Conditions and Risk of Non-Hodgkin Lymphoma: A Case-Control Study of Disease-Discordant Twin Pairs

Fri, 28 Aug 2015 00:00:00 +0100

We evaluated the association between common immune system–altering experiences and non-Hodgkin lymphoma (NHL) risk using a case-control study of 162 like-sex twin pairs discordant for NHL, identified from the International Twin Study. Information on medical history and evidence of childhood exposure to microbes was obtained by questionnaire from 1998 to 2002. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals. Intra-twin-pair agreement between twins on individual exposures was high (76%–97%). A negative association between NHL and seasonal hay fever (odds ratio (OR) = 0.28, 95% confidence interval (CI): 0.10, 0.75) and certain allergies (OR = 0.29, 95% CI: 0.13, 0.68) was observed. The number of atopic diseases was negatively associate...



Post-Transplant Lymphoproliferative Disorder (PTLD) Manifesting in the Oral Cavity of a 13-Year-Old Liver Transplant Recipient (LTx).

Fri, 21 Aug 2015 21:10:03 +0100

CONCLUSIONS All oral pathological lesions in organ transplant recipients need to be surgically removed and histopathologically examined because they present an increased risk of neoplastic transformations such as PTLD. PMID: 26285106 [PubMed - in process] (Source: Annals of Transplantation)

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Invasive Fusobacterium necrophorum infections and Lemièrre’s syndrome: the role of thrombophilia and EBV

Thu, 13 Aug 2015 23:04:55 +0100

This study confirms earlier studies of the clinical spectrum caused by F. necrophorum. For Lemièrre’s syndrome, the study adds to the knowledge on thromboembolic outcome, demonstrating that jugular vein thrombosis may cause severe complications. The time to treatment seems to be important for the risk of severe disease. In this study, concomitant EBV infection or underlying thrombophilia was uncommon. (Source: European Journal of Clinical Microbiology and Infectious Diseases)



New Hope for Vaccine Against Germ That Causes 'Mono'

Thu, 13 Aug 2015 20:00:00 +0100

Shot seems to work against Epstein-Barr virus in mice and monkeys, but human trials are still to come Source: HealthDay Related MedlinePlus Pages: Immunization, Infectious Mononucleosis (Source: MedlinePlus Health News)



Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection

Wed, 05 Aug 2015 00:00:00 +0100

Publication date: 4 August 2015 Source:Cell Reports, Volume 12, Issue 5 Author(s): Obinna Chijioke, Anne Müller, Regina Feederle, Mario Henrique M. Barros, Carsten Krieg, Vanessa Emmel, Emanuela Marcenaro, Carol S. Leung, Olga Antsiferova, Vanessa Landtwing, Walter Bossart, Alessandro Moretta, Rocio Hassan, Onur Boyman, Gerald Niedobitek, Henri-Jacques Delecluse, Riccarda Capaul, Christian Münz (Source: Cell Reports)



IL-10-592 A/C polymorphisms is associated with EBV-HLH in Chinese children.

Fri, 31 Jul 2015 12:22:38 +0100

Conclusion IL-10-592 locus gene polymorphism is associated with the development of EBV-HLH in Chinese children. PMID: 26222684 [PubMed - as supplied by publisher] (Source: Hematology)

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False positivity of monospot test in an immunocompetent elderly woman with acute cytomegalovirus infection

Tue, 21 Jul 2015 00:00:00 +0100

A 75-year-old woman presented with altered mental status, septic picture and influenza-like symptoms. Initial investigations revealed atypical lymphocytosis, thrombocytopenia, elevated liver enzymes and positive monospot test. Further investigation showed the EBV viral capsid antibody IgM/IgG and EBV DNA by PCR to be negative, however, interestingly her cytomegalovirus IgM and IgG were positive suggesting her mononucleosis like syndrome was due to acute CMV infection. Herein, we report the first case of a heterophile positive mononucleosis syndrome caused by acute CMV infection in an elderly immunocompetent woman. (Source: The American Journal of Emergency Medicine)



An unusual cause of sore throat and neck swelling

Mon, 20 Jul 2015 00:00:00 +0100

From the question on page 625 Clinical introduction A 61-year-old man presented with swelling of the neck. He had experienced coughing, fever and sore throat for the previous few days and had been started on antibiotic treatment by his general practitioner. He presented to the emergency department because the symptoms failed to subside and he developed swelling of his neck. On examination, he was afebrile, and a hard, 9x4 cm in size, mobile mass with no redness was observed on the right side of his neck (figure 1). Question What is your diagnosis?Pneumonia Tuberculosis Q fever Lemierre's syndrome Mononucleosis For the answer see page 646 Answer: D Lemierre's syndrome (LS). LS is also known as anaerobic postanginal septicaemia. The primary site of infection is the palatine tonsils and ...



Diagnosis of infectious mononucleosis

Sat, 18 Jul 2015 16:26:52 +0100

No abstract available (Source: The Nurse Practitioner)



A rare case of acute pancreatitis and life-threatening hemolytic anemia associated with Epstein–Barr virus infection in a young healthy adult

Thu, 16 Jul 2015 00:00:00 +0100

Epstein–Barr virus (EBV) is a common infection that affects 95% of adults worldwide at some point during life. It is usually asymptomatic or causes a self-limiting clinical syndrome known as infectious mononucleosis. It rarely causes complications. Here, we present a case of a healthy 21-year-old female college student who suffered from severe pancreatitis and life-threatening autoimmune hemolytic anemia in association with EBV infection, and we also discuss the common presentation of EBV infection and the diagnosis and treatment of simple and complicated EBV infection. (Source: Journal of Infection and Public Health)



Atypical lymphocytes and eosinophilia in primary cytomegalovirus mononucleosis

Tue, 07 Jul 2015 00:00:00 +0100

(Source: British Journal of Haematology)

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Chronic active EBV infection with mainly cutaneous manifestation in a Caucasian woman with long-term follow-up.

Sat, 04 Jul 2015 00:00:00 +0100

This article is protected by copyright. All rights reserved. PMID: 26148205 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)



Lymphoma-Like Syndrome: 4 Case Reports About Atypical Presentation of Primary Cytomegalovirus Infection in Immunocompetent Children

Wed, 01 Jul 2015 05:00:00 +0100

We report 4 cases of lymphoma-like syndrome. The median duration of fever was 21.5 days (range 15–27). Tonsillitis and hepatitis are most of the time missing. A probable malignant diagnosis was raised in 3 cases. Clinical outcome was protracted (15–35 days) but favorable. To our knowledge, our study is the first pediatric case series of lymphoma-like syndrome. This clinical presentation is a source of delayed diagnosis due to diagnosis pitfall. (Source: Medicine)



Prolonged hepatitis and jaundice: a rare complication of paediatric Epstein-Barr virus infection.

Wed, 01 Jul 2015 00:00:00 +0100

Authors: Tan ZH, Phua KB, Ong C, Kader A Abstract We herein report the case of a 14-year-old girl with Epstein-Barr virus (EBV) infectious mononucleosis who developed prolonged hepatitis and jaundice. At presentation, she had tender hepatomegaly with a markedly deranged liver function test. Abdominal ultrasonography showed hepatomegaly and a thickened gallbladder wall. During the subsequent 11 weeks, her transaminases showed two further peaks, which corresponded with clinical deterioration. Her highest alanine transaminase level was 1,795 µ/L and total bilirubin level was 154 µmol/L. She recovered fully with conservative management. EBV-related liver involvement is typically mild and self-limiting. We believe that tender hepatomegaly and gallbladder thickening may be important pr...



Problem diagnostyczny: gorączkujący nastolatek z rzadkim zespołem chorobowym

Fri, 26 Jun 2015 00:00:00 +0100

Publication date: Available online 15 May 2015 Source:Pediatria Polska Author(s): Paweł Małecki , Agnieszka Gałek , Jadwiga Małdyk , Ludomiła Machowska , Katarzyna Jończyk-Potoczna , Katarzyna Derwich Haemophagocytic syndrome (hemophagocytic lymphohistiocytosis, HLH) is a rare hematologic disorder which manifests itself by inflammatory reaction caused by incorrect activation of immune cells. A 16-year-old boy was admitted to the hospital with a high fever, respiratory distress, dyspnea, rash and hepatosplenomegaly. The differential diagnosis initially considered infectious mononucleosis and Kawasaki disease. Eventually the boy was transferred to the Department of Pediatric Oncology, Hematology and Transplantology in Poznań in which, in the course of extensive diagnosis, HLH trigge...



Novel Association of Killer Cell Immunoglobulin-like Receptor Genes with EBV-infectious Diseases in Children

Fri, 19 Jun 2015 00:00:00 +0100

Publication date: April 2015 Source:Biomedical and Environmental Sciences, Volume 28, Issue 4 Author(s): Li HUO , Ming Yan JIANG , Qiang LI , Yi Ping ZHU Killer cell immunoglobulin-like receptors (KIRs) which are mainly expressed on natural killer (NK) cells are implicated in many virus infections. However, it is unclear whether or not KIRs are associated with susceptibility to Epstein-Barr virus (EBV) infection related diseases. Therefore, the purpose of our study was to investigate possible correlation between polymorphisms of KIR genes and infectious mononucleosis (IM)/EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). The polymorphisms of KIR genes were detected by polymerase chain reaction with sequence-specific primers (PCR-SSP). The results would contribute to clarify th...

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Successful Immunosuppressive Therapy for Severe Infectious Mononucleosis in a Patient with Clonal Proliferation of EBV-infected CD8-positive Cells.

Tue, 16 Jun 2015 20:31:26 +0100

Authors: Hosoi H, Sonoki T, Murata S, Mushino T, Kuriyama K, Nishikawa A, Hanaoka N, Ohshima K, Imadome K, Nakakuma H Abstract A 30-year-old woman was diagnosed with severe infectious mononucleosis (IM). The Epstein-Barr virus (EBV) had infected both CD19- and CD8-positive cells, and clonal proliferation of EBV-infected cells and T-cells was detected. Although we suspected malignant lymphoma, her condition improved following immunosuppressive therapy. A similar case was recently reported; therefore, this case is the second case of IM with EBV-infected CD8-positive cells and clonal proliferation of EBV-infected cells. Our results demonstrate that the clonal proliferation of EBV-infected cells is not always an indication for chemotherapy in the primary infection phase and that monito...



Infectious mononucleosis skin rash without previous antibiotic use

Tue, 09 Jun 2015 00:00:00 +0100

Publication date: Available online 9 June 2015 Source:The Brazilian Journal of Infectious Diseases Author(s): Theocharis Koufakis , Ioannis Gabranis (Source: The Brazilian Journal of Infectious Diseases)



Infectious mononucleosis skin rash without previous antibiotic use.

Tue, 09 Jun 2015 00:00:00 +0100

Authors: Koufakis T, Gabranis I PMID: 26070538 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)



The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children.

Thu, 04 Jun 2015 05:22:06 +0100

CONCLUSIONS: The incidence of IM peaks among preschool children and youth patients in Beijing, China. The levels of liver enzymes and atypical lymphocytes increase with age. PMID: 24459643 [PubMed - indexed for MEDLINE] (Source: Clinical and molecular hepatology)



Anaplastic large-cell lymphoma presenting as a nasopharyngeal mass and cervical lymphadenopathy.

Mon, 01 Jun 2015 00:00:00 +0100

Authors: Dion GR, Packer MD Abstract Cervical lymphadenopathy in adults has a broad differential diagnosis, including bacterial and viral infections, Kikuchi-Fujimoto disease, systemic lupus erythematosus, and various neoplasms. Many of its etiologies share similar symptomatology and presentations, which complicates the diagnosis. A thorough history and a comprehensive physical examination, to include nasopharyngoscopy and imaging as indicated by the specific case, are key to determining the origin of the lymphadenopathy and to avoid a missed or delayed diagnosis. Based on our review of the literature, we present the second reported case of anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma presenting in an adult with an obstructing adenoid/nasopharyngeal mass and l...

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323 Cytomegalovirus (CMV) primoinfection caused serious deterioration in 2 young CF fathers

Mon, 01 Jun 2015 00:00:00 +0100

CMV is a highly prevalent virus in the adult population (60–100%) and in healthy adults is usually asymptomatic or causes only a mild mononucleosis-like syndrome. We, here, report on 2 CF patients, who contracted a CMV primoinfection, which caused significant morbidity.Patient 1 was a 41 year-old CMV-negative man who suffered from severe, but only slowly progressive, CF lung disease and ABPA. In 08/2013, he presented with an acute pulmonary exacerbation and fever, which was unusual, as well as asthenia. (Source: Journal of Cystic Fibrosis)



A Rare Case of Primary EBV Infection causing Acute Acalculous Cholecystitis

Mon, 25 May 2015 00:00:00 +0100

Publication date: Available online 14 May 2015 Source:Journal of Pediatric Surgery Case Reports Author(s): Sonia Shah , Sangeeta Schroeder Primary Epstein-Barr Virus (EBV) infection in children is common and frequently asymptomatic. While symptomatic patients typically present with features of infectious mononucleosis, a rare complication of primary EBV is acute acalculous cholecystitis. A 6 year old previously healthy boy presented with 6 days of low-grade fevers, non-bloody non-bilious vomiting, and periumbilical pain. Based on clinical, laboratory, and radiographic evidence, the patient was diagnosed with acute acalculous cholecystitis due to a primary EBV infection. The patient improved with supportive therapy and remained asymptomatic at follow-up. Overall, clinicians should conside...



Study of SH2D1A gene mutation in paediatric patients with B-cell lymphoma.

Wed, 13 May 2015 00:00:00 +0100

CONCLUSIONS: This is the first study to analyse the SH2D1A gene mutations in Iranian paediatric patients diagnosed with lymphoma. Although we could not demonstrate such an association in our cohort of patients, larger, multi-centre studies are required to extend and confirm our early findings. PMID: 25982576 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)



Risk factors for multiple sclerosis, neuromyelitis optica and transverse myelitis

Thu, 07 May 2015 00:00:00 +0100

Conclusions: Established MS risk factors do not appear to be associated with susceptibility to TM or NMO and, among MS patients, these risk factors appear to act independently. (Source: Multiple Sclerosis)



Microbial interaction of periodontopathic bacteria and Epstein-Barr virus and their implication of periodontal diseases

Fri, 24 Apr 2015 00:00:00 +0100

Publication date: August 2012 Source:Journal of Oral Biosciences, Volume 54, Issue 3 Author(s): Kenichi Imai , Yorimasa Ogata , Kuniyasu Ochiai Epstein-Barr virus (EBV) is a ubiquitous human gamma herpesvirus that infects more than 90% of the world's population. EBV infection causes several human diseases, including infectious mononucleosis, autoimmune disorders, and a number of malignancies. Interestingly, evidence accumulated over the past 10 years supports the role for EBV as a pathogenic agent of periodontal disease because bacterial activities alone do not explain several of its clinical characteristics. Despite this, it remains unclear how EBV is reactivated in the oral cavity and how activated EBV leads to the progression of periodontal diseases. We focused on the microbial intera...

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Researchers shed light on link between diet, Epstein-Barr

Wed, 08 Apr 2015 15:33:03 +0100

A new study is shedding light on the connection between diet and a common childhood disease. Using national health data, the researchers determined children who ate certain types of food or dealt with food insecurity may be more likely to contract the Epstein-Barr virus (EBV). EBV is a common virus that often causes no symptoms on its own; it’s better known as a cause of infectious mononucleosis and having a connection to some cancers. (Source: ScienceDaily Headlines)



Alice in Wonderland Syndrome:A History (P6.337)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: AIWS has multiple etiologies, generation of hallucinations reflect abnormal cerebral perfusion and its symptoms were not first described by Lippman, but probably by William Gowers. Study Supported by: Faculty Practice SalariesDisclosure: Dr. Fine has received personal compensation in an editorial capacity for Encyclopedia of Neurological Sciences. Dr. Fine holds stock and/or stock options in Bristol Myers-Squibb, Merck, Eli Lilly & Company, Pzifer, and Johnson & Johnson Dr. Sofat has nothing to disclose. Dr. Mahfooz has nothing to disclose. Dr. Fiddler has nothing to disclose. Dr. Farooq has nothing to disclose. (Source: Neurology)



Hypovitaminosis D and the Risk of Multiple Sclerosis in Blacks and Hispanics (P2.207)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: Hypovitaminosis D does not appear to be a risk factor for MS in Hispanics and blacks. These findings highlight the complexity of unraveling the relationship between vitamin D and MS and the importance of including multiple racial/ethnic groups in MS susceptibility studies. Study Supported by: NINDS-NIH-R01NS075308Disclosure: Dr. Langer-Gould has received research support from Biogen Idec and Roche Diagnostics Corporation. Dr. Chen has nothing to disclose. Dr. Lucas has nothing to disclose. Dr. Xiang has nothing to disclose. Dr. Barcellos has nothing to disclose. (Source: Neurology)



Genes and Environment in Multiple Sclerosis (GEMS) Study: Leveraging electronic communication to enable a prospective study of individuals at risk of multiple sclerosis (S38.007)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: The GEMS study highlights the role of electronic communication in rapid and large-scale subject recruitment of first-degree relatives, and provides a first estimate of the incidence of MS among this high-risk population, critically informing the design of a prospective study of high-risk family members.Disclosure: Dr. Xia has nothing to disclose. Dr. Chibnik has nothing to disclose. Dr. De Jager has received personal compensation for activities with Teva Neuroscience and Biogen Idec. Dr. De Jager has received research support from Biogen Idec and Sanofi/Genzyme. (Source: Neurology)



Clinical and Etiopathological Evaluation of the Patients with OCB IgG Pattern-IV and V Positivity (P5.220)

Wed, 08 Apr 2015 00:00:00 +0100

CONCLUSIONS: In our study group, MS had consisted the major part of OCB pattern-IV positive patients. Although, pattern-V was not found frequently as expected in monoclonal gammapathies, peripheral inflammatory polyneuropathies and vasculitis were involved in the first line.Disclosure: reports receiving honoraria from Merck-Serono and Teva.; S, Dr. Akkas-Yazici has nothing to disclose. Dr. Uygunoglu has nothing to disclose. Dr. Saruhan-Direskeneli has nothing to disclose. Dr. P. Yentur has nothing to disclose. Dr. Saip has nothing to disclose. (Source: Neurology)

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Diet and EBV infection

Tue, 07 Apr 2015 23:00:00 +0100

American research has found that people with a bad diet or who ate beans, red meat and fruit juice daily had a higher risk of being infected by the virus that can cause glandular fever. Newswise Epstein Barr virus (EBV) - A to Z of MS (Source: Multiple Sclerosis Trust)



Novel Association of Killer Cell Immunoglobulin-like Receptor Genes with EBV-infectious Diseases in Children.

Wed, 01 Apr 2015 00:00:00 +0100

Authors: Huo L, Jiang MY, Li Q, Zhu YP Abstract Killer cell immunoglobulin-like receptors (KIRs) which are mainly expressed on natural killer (NK) cells are implicated in many virus infections. However, it is unclear whether or not KIRs are associated with susceptibility to Epstein-Barr virus (EBV) infection related diseases. Therefore, the purpose of our study was to investigate possible correlation between polymorphisms of KIR genes and infectious mononucleosis (IM)/EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). The polymorphisms of KIR genes were detected by polymerase chain reaction with sequence-specific primers (PCR-SSP). The results would contribute to clarify the association of KIRs with EBV induced diseases, and provide new insights into the role of NK cells ...



Infectious Mononucleosis

Tue, 17 Mar 2015 00:00:00 +0100

Infectious mononucleosis, also known as “mono,” is an illness that usually affects adolescents and young adults. (Source: JAMA)



Common questions about infectious mononucleosis.

Sun, 15 Mar 2015 00:00:00 +0100

Authors: Womack J, Jimenez M Abstract Epstein-Barr is a ubiquitous virus that infects 95% of the world population at some point in life. Although Epstein-Barr virus (EBV) infections are often asymptomatic, some patients present with the clinical syndrome of infectious mononucleosis (IM). The syndrome most commonly occurs between 15 and 24 years of age. It should be suspected in patients presenting with sore throat, fever, tonsillar enlargement, fatigue, lymphadenopathy, pharyngeal inflammation, and palatal petechiae. A heterophile antibody test is the best initial test for diagnosis of EBV infection, with 71% to 90% accuracy for diagnosing IM. However, the test has a 25% false-negative rate in the first week of illness. IM is unlikely if the lymphocyte count is less than 4,000 mm3....



Isolated oculomotor nerve palsy revealing infectious mononucleosis

Mon, 09 Mar 2015 00:00:00 +0100

(Source: Acta Ophthalmologica)

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Return to play or riding the pachyderm: a call for standards based on Swiss values

Tue, 03 Mar 2015 00:00:00 +0100

Return to play (RTP) is an important issue in sports medicine; it is the other ‘bookend’ to effective prevention strategies for sports injury. Both share common goals and challenges and are critical to the multiple stakeholders in elite sports. RTP decisions are made in classical injuries such as sports concussion or ACL reconstruction, and are also made in infectious disease such as mononucleosis (splenic involvement) or frequently underdiagnosed myocarditis, and in less well-defined conditions such as disordered eating. Overuse injuries also present a challenge for RTP, whether in adolescents (apophyseal injuries) or adults (tendinopathies). While some of these conditions have clear diagnostic criteria, others do not and pose a greater problem with regard to readiness to play...



Epstein-Barr Virus Infectious Mononucleosis Presenting With Persistent Cough Mimicking Pertussis and Supraclavicular Adenopathy Mimicking Lymphoma

Sun, 01 Mar 2015 06:00:00 +0100

Abstract: This case has important clinical implications of Epstein-Barr virus (EBV) infectious mononucleosis (IM) that mimic with unusual manifestations. This is the first such case in an adult with a prolonged pertussoid cough and unilateral supraclavicular adenopathy. The patient was a 21-year-old white woman who presented with fever, fatigue, and protracted dry cough. The clue to the diagnosis on physical examination was a Hoagland sign, that is, bilateral upper eyelid edema. There are many lessons from this case. First, EBV IM may present without bilateral posterior cervical/generalized adenopathy. Although her fatigue and unilateral supraclavicular adenopathy, elevated ferritin level, and elevated alkaline phosphatase suggested possible lymphoma, Hoagland sign pointed to the diagnosis...



Necrotizing tonsillitis caused by group C beta-hemolytic streptococci.

Sun, 01 Mar 2015 00:00:00 +0100

Authors: Bastaki JM Abstract Tonsillitis and pharyngitis are among the most common infections in the head and neck. Viral tonsillitis is usually caused by enterovirus, influenza, parainfluenza, adenovirus, rhinovirus and Epstein-Barr virus (causing infectious mononucleosis). Acute bacterial tonsillitis is most commonly caused by group A beta-hemolytic streptococci. On the other hand, pseudomembranous and necrotizing tonsillitis are usually caused by fusiform bacilli and spirochetes. Here we report what is, to our knowledge, the first case of necrotizing tonsillitis caused by group C beta-hemolytic streptococci. PMID: 25738719 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)