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MedWorm: Genital Warts



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Genital Warts category.



Last Build Date: Tue, 29 Mar 2016 16:33:11 +0100

 



Global challenges of implementing human papillomavirus vaccines

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: Every year cervical cancer affects around 528000 women and causes 266000 deaths worldwide with 80% of deaths occurring in less developed countries with a concomitant 18-fold difference in mortality occurring between developed and developing countries. Cervical cancers is caused by the Human Papilloma Virus (HPV) with the oncogenic types 16 and 18 accounting for 70% of invasive disease. Other cancers associated with HPV infection include vaginal, vulvar, penile, oropharyngeal and anal cancers. (Source: International Journal of Infectious Diseases)

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Factors associated with Ano-genital warts occurrence among Human Immunodeficiency Virus (HIV) infected patients in Gauteng, South Africa

Tue, 29 Mar 2016 09:23:38 +0100

Background: The study highlighted factors associated with the occurrence of ano-genital warts (AGWs) among HIV infected individuals in South Africa (SA). Human Papilloma Virus (HPV) infection occurs more frequently among HIV infected individuals because of their compromised immuno-status. (Source: International Journal of Infectious Diseases)



The epidemiological survey of HPV infection in married women referring to Firoozgar Hospital

Tue, 29 Mar 2016 09:23:38 +0100

Background: The human papillomavirus (HPV) is the main cause of cervical cancer in developing countries. HPV is common in all socioeconomic groups and is spread all over the world. There are more than 100 types of HPV which are divided into high risk and low risk groups. Molecular method is one of the rapid and accurate methods to study HPV genotypes. (Source: International Journal of Infectious Diseases)



Identification of human papillomavirus types causing lesions in penile canerous, pre-cancerous and benign lesions using laser microdissection

Tue, 29 Mar 2016 09:23:35 +0100

Background: Almost half of penile cancers and the majority of penile warts are associated with the two HR types (HPV 16 and HPV 18) and two LR HPV types (HPV 6 and HPV 11), respectively. It is therefore important to document the burden HPV associated diseases of the penis and identify the HPV types associated with the diseases. HPV E6 and E7 mRNA detection is the best indicator of HPV status that is clinically relevant as it indicate transcriptionally active HR HPV infection in lesions. In HR HPV infection an increase in E6 and E7 mRNA expression causes an overexpression of p16INK4A and thus used as a cellular correlate of the increased expression of HR HPV E6 and E7 mRNA in cervical samples. (Source: International Journal of Infectious Diseases)



Assessment of Human Papillomavirus (HPV) type 16 and 18 status by nested multiplex PCR in cervical cancer patients and in healthy women from a tertiary care hospital

Tue, 29 Mar 2016 09:23:35 +0100

Background: Cervical cancer is the most common malignancy in Indian women and approximately 130,000 women fall prey to cervical cancer every year. HPV DNA testing can be used as an adjunct to cytological screening of cervical samples of above 30 year old women and can be used as an optional test for follow-up in women who have slightly abnormal Pap test results. The aim of the study was to assess the HPV 16 and 18 status in cervical cancer patients and in healthy women visiting JIPMER, Pondicherry. (Source: International Journal of Infectious Diseases)



Universal HPV Vaccination of Girls Prevents Genital Warts in Young MenUniversal HPV Vaccination of Girls Prevents Genital Warts in Young Men

Mon, 28 Mar 2016 19:39:01 +0100

In Denmark, the human papillomavirus (HPV) vaccination program for girls and women has been followed by a decreased incidence of genital warts in young men. Reuters Health Information (Source: Medscape Medical News Headlines)

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Influence of Gender and Gender-Specific Recommendations on Adolescent Human Papillomavirus Vaccination

Sun, 27 Mar 2016 22:00:00 +0100

Conclusions Changing HPV vaccine recommendations had minimal cross-gender impact. Early adoption and timely completion patterns were mostly similar across genders. (Source: American Journal of Preventive Medicine)



Association of genetic variants with tumor HPV16 status and survival in squamous cell carcinoma of the oropharynx

Sun, 27 Mar 2016 22:00:00 +0100

Squamous cell carcinoma of the oropharynx (SCCOP) is a subtype of squamous cell carcinoma of the head and neck (SCCHN) [1]. In the U.S., approximately 13,510 new cases of SCCOP are diagnosed, and 2330 deaths result from these cancers, annually [2]. Although tobacco smoking and alcohol consumption remain significant risk factors for SCCOP, human papillomavirus (HPV) accounts for a growing proportion of cases, particularly in young adults [1,3]. There are more than 100 different HPV types; about 20 of these have oncogenic potential (i.e., the high-risk types) [4]. (Source: Oral Oncology)



Risk factors associated with incident sexually transmitted infections in HIV‐positive patients in the Australian HIV Observational Database: a prospective cohort study

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsIn this cohort of individualsbeing treated with antiretroviral drugs, those who were MSM, who were 30–39 years old, and who had a prior history of STI, were at highest risk of a further STI diagnosis. (Source: HIV Medicine)



Lifelong widespread warts associated with human papillomavirus type 70/85: a new diagnostic entity?

Sun, 27 Mar 2016 12:33:04 +0100

We present a patient with HPV 70/85-positive widespread cutaneous warts characterized by clinical and histological features atypical for classic generalized verrucosis or epidermodysplasia verruciformis. The cutaneous HPV infection is characterized by verrucous papules or plaques variable in size, number, and distribution depending on the genotype of HPV involved and the immune status of the patient. Human papillomaviruses comprise five genera (alpha, beta, gamma, mu, and nu papillomavirus) with different life-cycle characteristics, epithelial tropisms, and disease associations. Epidermodysplasia verruciformis (EV) is a rare, lifelong, autosomal recessive skin disease characterized by persistent cutaneous human papillomavirus infection not necessarily associated with immune system defects...



mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Coppock JD, Vermeer PD, Vermeer DW, Lee KM, Miskimins WK, Spanos WC, Lee JH Abstract Effective treatments for recurrent/metastatic human papillomavirus-positive (HPV+) head and neck squamous cell cancer (HNSCC) are limited. To aid treatment development, we characterized a novel murine model of recurrent/metastatic HPV+ HNSCC. Further analysis of the parental tumor cell line and its four recurrent/metastatic derivatives led to preclinical testing of an effective treatment option for this otherwise fatal disease. Reverse phase protein arrays identified key signaling cascades in the parental and recurrent/metastatic cell lines. While protein expression profiles differed among the recurrent/metastatic cell lines, activated proteins associated with the mTOR signaling cascade we...

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Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Gu Y, Ma C, Zou J, Zhu Y, Yang R, Xu Y, Zhang Y Abstract A complete understanding of the natural history of infection with high-risk human papillomaviruses (HPVs) in cervical cancer requires data from regional and ethnic studies. The prevalence of high-risk HPVs was evaluated retrospectively in 2040 patients with cervicitis, 239 with cervical intraepithelial neoplasia grade 1 (CIN1), 242 with CIN2/3, and 42 patients with invasive squamous cell carcinoma (SCC) based on data from patients who visited our hospital between May 2013 and May 2015. The rates of high-risk HPV infection in patients with cervicitis, CIN1, CIN2/3, and invasive SCC were 40.8%, 74.9%, 70.2%, and 83.3%, respectively. The three most dominant HPV genotypes were HPV16, 58, and 52. HPV16 and HPV58 positivit...



Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD Abstract Human papillomavirus induced (HPV+) cancer incidence is rapidly rising, comprising 60-80% of oropharyngeal squamous cell carcinomas (OPSCCs); while rare, recurrent/metastatic disease accounts for nearly all related deaths. An in vivo pre-clinical model for these invasive cancers is necessary for testing new therapies. We characterize an immune competent recurrent/metastatic HPV+ murine model of OPSSC which consists of four lung metastatic (MLM) cell lines isolated from an animal with HPV+ OPSCC that failed cisplatin/radiation treatment. These individual metastatic clonal cell lines were tested to verify their origin (parental transgene expression and define their physiologi...



A Common Clinical Dilemma: Management of Abnormal Vaginal Cytology and Human Papillomavirus Test Results

Sat, 26 Mar 2016 08:13:15 +0100

Conclusions: Vaginal cancer is rare, and asymptomatic low-risk women should not be screened. An algorithm based on expert opinion is proposed for managing women with abnormal vaginal test results. (Source: Journal of Lower Genital Tract Disease)



A Cross-Sectional Study of Human Papillomavirus Vaccine Utilization Among University Women: The Role of Ethnicity, Race, and Risk Factors

Sat, 26 Mar 2016 08:13:15 +0100

Conclusions: Human papillomavirus vaccine is highly acceptable among college women, particularly among Hispanic women. Efforts to vaccinate should include time of college enrollment. Such efforts are critical for the large scale prevention of cervical cancer and its precursor lesions and ultimately for preventable cervical cancer mortality. (Source: Journal of Lower Genital Tract Disease)



A Randomized Trial of Human Papillomavirus Self-Sampling as an Intervention to Promote Cervical Cancer Screening Among Women With HIV

Sat, 26 Mar 2016 08:13:15 +0100

Conclusions: The intervention did not improve cytology test attendance, although education about HPV and cervical cancer risk as part of study procedures was associated with testing for 35% of this group of women whose previous cytology occurred an average of 3.6 years before the baseline appointment. Self-sampling for HPV testing was feasible. (Source: Journal of Lower Genital Tract Disease)

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Introducing a High-Risk HPV DNA Test Into a Public Sector Screening Program in El Salvador

Sat, 26 Mar 2016 08:13:15 +0100

Conclusions: Women in the CM arm were less likely to complete care than women in the ST arm. Targeted outreach to underscreened women successfully identified women with higher prevalence of HPV and possibly higher disease burden. (Source: Journal of Lower Genital Tract Disease)



Performance of an Human Papillomavirus Test in Samples From Women With Histolopathologically Confirmed Invasive Cervical Cancer

Sat, 26 Mar 2016 08:13:15 +0100

Conclusions: With a sensitivity of 94% of the first HPV test, 6 of 100 cervical cancers will be missed if this was the only test used in a population screening program. The missed cancers were however all clinically detectable. (Source: Journal of Lower Genital Tract Disease)



Comparison of Colposcopic Impression Based on Live Colposcopy and Evaluation of Static Digital Images

Sat, 26 Mar 2016 08:13:15 +0100

Conclusions: Colposcopic impressions of acetowhitening or worse are highly sensitive for identifying cervical precancers and reproducible on static image-based pattern recognition. (Source: Journal of Lower Genital Tract Disease)



Characterization of cervical cancer stem cell-like cells: phenotyping, stemness, and Human Papilloma Virus co-receptor expression.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Ortiz-Sánchez E, Santiago-López L, Cruz-Domínguez VB, Toledo-Guzmán ME, Hernández-Cueto D, Muñiz-Hernández S, Garrido E, Cantú-De León D, García-Carrancá A Abstract Cancer stem cells (CSC) exhibit high tumorigenic capacity in several tumor models. We have now determined an extended phenotype for cervical cancer stem cells. Our results showed increased CK-17, p63+, AII+, CD49f+ expression in these cells, together with higher Aldehyde dehydrogenase (ALDHbright)activity in Cervical CSC (CCSC) enriched in cervospheres. An increase in stem cell markers, represented by OCT-4, Nanog, and β-catenin proteins, was also observed, indicating that under our culture conditions, CCSC are enriched in cervospheres, as compared to monolayer cultures. In addition, we were able to...



Association between sexually transmitted disease and church membership. A retrospective cohort study of two Danish religious minorities

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions The cohort shows significant lower incidence of STD, most likely including human papillomavirus, which may partly explain the lower incidence of cancers of the cervix, rectum, anus, head and neck. (Source: BMJ Open)

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Committee Opinion No. 661: Integrating Immunizations Into Practice.

Thu, 24 Mar 2016 18:43:02 +0100

Authors: Abstract Immunization against vaccine-preventable diseases is an essential component of women's primary and preventive health care. Despite the importance of vaccination and clear guidance from public health agencies, rates of vaccination lag behind national goals. Obstetrician-gynecologists can play a major role in reducing morbidity and mortality from a range of vaccine-preventable diseases, including pertussis, influenza, human papillomavirus, and hepatitis. Given demonstrated vaccine efficacy and safety, and the large potential for prevention of many infectious diseases that affect adults, pregnant women, and newborns, obstetrician-gynecologists should include immunizations as an integral part of their practice. To do so, they must embrace their role as important sour...



Committee Opinion No. 661 Summary: Integrating Immunizations Into Practice.

Thu, 24 Mar 2016 18:43:02 +0100

Authors: Abstract Immunization against vaccine-preventable diseases is an essential component of women's primary and preventive health care. Despite the importance of vaccination and clear guidance from public health agencies, rates of vaccination lag behind national goals. Obstetrician-gynecologists can play a major role in reducing morbidity and mortality from a range of vaccine-preventable diseases, including pertussis, influenza, human papillomavirus, and hepatitis. Given demonstrated vaccine efficacy and safety, and the large potential for prevention of many infectious diseases that affect adults, pregnant women, and newborns, obstetrician-gynecologists should include immunizations as an integral part of their practice. To do so, they must embrace their role as important sour...



Sex differences in the incidence of skin and skin‐related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide

Thu, 24 Mar 2016 15:22:23 +0100

Abstract Many skin and skin‐related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin‐related diseases affecting males vs. females, we reviewed published population‐based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers. Males had a higher incidence of ...



Primary HPV testing: a proposal for co‐testing in initial rounds of screening to optimise sensitivity of cervical cancer screening

Wed, 23 Mar 2016 23:34:13 +0100

This article proposes a compromise: cytology and HPV co‐testing for the first two screening tests to optimise the sensitivity of the test as a whole. Registrations of invasive and in situ carcinoma of the uterine cervix in England indicate that the prevalence of the disease is highest in young women in the early rounds of screening. Calculations of the likely impact on the workload of this proposal have been based on a service evaluation of 295 cytology tests received at St Thomas’ Hospital, which suggests that the volume of cytology tests would be reduced by approximately 60% compared with 80% for primary HPV testing alone. This proposal should be debated openly before irrevocable changes are made to a skilled workforce. (Source: Cytopathology)



Transforming growth factor-β1 in carcinogenesis, progression, and therapy in cervical cancer

Wed, 23 Mar 2016 23:00:00 +0100

Abstract Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that plays important roles in cervical tumor formation, invasion, progression, and metastasis. TGF-β1 functions as a tumor inhibitor in precancerous lesions and early stage cancers of cervix whereas as a tumor promoter in later stage. This switch from a tumor inhibitor to a tumor promoter might be due to various alterations in TGF-β signaling pathway, such as mutations or loss of expression of TGF-β receptors and SMAD proteins. Additionally, the oncoproteins of human papillomaviruses have been shown to stimulate TGF-β1 expression, which in turn suppresses host immune surveillance. Thus, in addition to driving tumor cell migration and metastasis, TGF-β1 is believed to play a key role in promoting h...

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Lack of detection of human papillomavirus DNA in prostate carcinomas in patients from northeastern Brazil

Wed, 23 Mar 2016 07:43:49 +0100

This study included 104 tissue samples from primary prostate carcinoma cases. HPV DNA was purified and then amplified using MY09/11 and GP5+/GP6+ degenerate primer sets that detect a wide range of HPV types, and with specific PCR primers sets for E6 and E7 HPV regions to detect HPV 16. None of the samples showed amplification products of HPV DNA for primer sets MY09/11 and GP5+/GP6+, or the specific primer set for the E6 and E7 HPV regions. HPV infection, thus, does not seem to be one of the causes of prostate cancer in the population studied. (Source: Genetics and Molecular Biology)



Gardasil is destroying young girls' ovaries and reproductive systems

Wed, 23 Mar 2016 06:00:00 +0100

(NaturalNews) A new study has found that Merck & Co., the maker of the human papillomavirus (HPV) vaccine Gardasil, neglected to examine the drug's effect on the reproductive systems of women.As a result of that neglect, as well as the inherent dangers behind the vaccine, an Australian... (Source: NaturalNews.com)



ACS Releases Long-term Care Guideline for Survivors of Head and Neck Cancer

Wed, 23 Mar 2016 00:17:05 +0100

By Stacy Simon The American Cancer Society has released a new Head and Neck Survivorship Care Guideline to help survivors of head and neck cancer and their primary care providers better manage their long-term care. The guideline addresses cancers of the oral cavity, tongue, lip, pharynx (throat), and larynx (voice box). Recommendations in the guideline may also apply to cancers of the salivary glands, nasal and paranasal sinuses, and nasopharynx. But it does not address cancers of the brain, thyroid, or esophagus because they are very different in terms of symptoms and treatment. RESOURCES: Head and Neck Cancer Survivorship Care GuidelineHead and Neck Cancer Survivorship Guideline Patient PageNutrition and physical activity guidelines for cancer survivorsSurvivorship care plansOnline co...



Human papillomavirus mRNA and DNA testing in women with atypical squamous cells of undetermined significance: A prospective cohort study

Tue, 22 Mar 2016 23:00:00 +0100

In conclusion, the HPV16/18/31/33/45 mRNA test is not optimal for ASC‐US triage due to its low sensitivity and the substantial risk for precancer following a negative test. This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



HPV vaccines are harming and killing victims worldwide in a silent epidemic of medical violence against children

Tue, 22 Mar 2016 06:00:00 +0100

(NaturalNews) One highly controversial Human Papillomavirus (HPV) vaccine, Gardasil, which is administered to young girls ostensibly to defend against an early onset of the only form of contagious cancer, has actually been responsible for more than 30 deaths, according to the site... (Source: NaturalNews.com)

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Characterization of human papillomavirus antibodies in individuals with head and neck cancer

Mon, 21 Mar 2016 23:00:00 +0100

Conclusions HPV16 antibodies were significantly more common in OPC versus non-OPC cases, particularly HPV16 E6 antibodies. (Source: Cancer Epidemiology)



Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma

Mon, 21 Mar 2016 23:00:00 +0100

ConclusionAmong patients with CUP, p16‐positive status is an independent predictor of DFS but not overall survival (OS). © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



Human papillomavirus integration pattern and demographic, clinical, and survival characteristics of patients with oropharyngeal squamous cell carcinoma

Mon, 21 Mar 2016 23:00:00 +0100

ConclusionThe majority of HPV‐positive oropharyngeal SCCs have either integrated or both episomal and integrated HPV with no significant differences in survival among the groups. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



[Is (chemo)radiotherapy really the future standard in the treatment of oropharyngeal carcinoma?]

Mon, 21 Mar 2016 10:54:03 +0100

Authors: Knecht R, Bussmann L, Möckelmann N, Lörincz BB Abstract Treatment of patients with oropharyngeal squamous cell carcinoma (OPSCC) requires interdisciplinary collaboration. Besides oncologic control, organ and function preservation are important priorities. One treatment option is primary concomitant chemoradiotherapy (CRT), particularly for locally advanced head and neck cancer. Another option is sequential CRT, where induction chemotherapy may be followed either by radiation alone or by CRT. An important aspect of these modalities is the development of functional sequelae with regards to swallowing as a direct consequence of radiogenic fibrosis, as well as tissue ctoxicity associated with cisplatin-based chemotherapy. Conventional open surgical approaches are being incr...



Immortalization capacity of HPV types is inversely related to chromosomal instability.

Mon, 21 Mar 2016 05:47:03 +0100

This study determined how the immortalization capacity of ten hrHPV types relates to DNA damage induction and overall genomic instability in HFKs.Twenty five cell cultures obtained by transduction of ten hrHPV types (i.e. HPV16/18/31/33/35/45/51/59/66/70 E6E7) in two or three HFK donors each were studied.All hrHPV-transduced HFKs showed an increased number of double strand DNA breaks compared to controls, without exhibiting significant differences between types. However, immortal descendants of HPV-transduced HFKs that underwent a prior crisis period (HPV45/51/59/66/70-transduced HFKs) showed significantly more chromosomal aberrations compared to those without crisis (HPV16/18/31/33/35-transduced HFKs). Notably, the hTERT locus at 5p was exclusively gained in cells with a history of crisis...

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Genomic analysis of HPV-positive versus HPV-negative oesophageal adenocarcinoma identifies a differential mutational landscape

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions These findings demonstrate distinct genomic differences between HPV-positive and HPV-negative OACs indicating different biological mechanisms of tumour formation. (Source: Journal of Medical Genetics)






Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus

Mon, 21 Mar 2016 00:00:00 +0100

Human papillomavirus (HPV) type 16 (HPV 16) plays an etiologic role in the majority of cases of squamous cell carcinoma of the oropharynx (SCCOP), particularly those occurring in middle-aged patients and patients with no smoking history [1–6]. Chaturvedi et al., in an analysis of US incidence trends for oral cavity and oropharynx cancers stratified by age, demonstrated that the incidence of squamous cell carcinoma of the oral cavity (SCCOC) decreased overall but increased significantly among adults younger than 40years, consistent with an increasing incidence of SCCOP across age groups [6]. (Source: Oral Oncology)



Adjuvant and Novel Treatment of Recurrent Respiratory Papillomatosis

Mon, 21 Mar 2016 00:00:00 +0100

Abstract Recurrent respiratory papillomatosis (RRP) is a rare benign neoplasm of the respiratory tract caused by human papillomavirus types 6 and 11. Surgical removal of the papilloma by microdebridement or laser is the current standard of care, but in most cases the disease recurs and patients require repeated surgical intervention. Over time, repeated procedures can lead to complications such as significant vocal cord scarring and laryngeal stenosis. There is therefore an urgent need for adjuvant treatments or alternative therapies that can control the disease or prevent recurrence, but unfortunately there is currently no known universally effective adjuvant therapy. Challenges for evaluating the effectiveness of adjuvant treatment in RRP include variable success rates in patien...



Genetic analysis of a novel splice‐site mutation in TMC8 reveals the in‐vivo importance of the TMC domain of TMC8

Sun, 20 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Genetic analysis of a novel splice-site mutation in TMC8 reveals the in-vivo importance of the TMC domain of TMC8.

Sat, 19 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. PMID: 26997147 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)



Prostate tumor overexpressed-1 in conjunction with human papillomavirus status, predicts outcome in early-stage human laryngeal squamous cell carcinoma.

Sat, 19 Mar 2016 17:51:03 +0100

Authors: Yang L, Wang H, Wang Y, He Z, Chen H, Liang S, He S, Wu S, Song L, Chen Y Abstract In human cancer, molecular markers combined with clinical characteristics are used increasingly to predict prognosis. Prostate tumor overexpressed-1 (PTOV1), first identified in prostate cancer, is a key factor in tumor progression and correlates with unfavorable clinical outcomes. HPV infection status was tested by HPV E6-targeted multiplex real-time PCR and p16 immunohistochemistry (IHC). Real-time PCR and western blotting analyses were used to examine the mRNA and protein expression levels of PTOV1 in eight paired LSCC samples. IHC was performed to assess PTOV1 protein expression in 196 paraffin-embedded, archived LSCC samples. PTOV1 protein and mRNA expression was increased in LSCC tissu...



Using the Cancer Risk Management Model to evaluate the health and economic impacts of cytology compared with human papillomavirus DNA testing for primary cervical cancer screening in Canada.

Sat, 19 Mar 2016 17:44:02 +0100

CONCLUSIONS: Changing from cytology to hpv dna testing as the primary screening test for cervical cancer would be an acceptable strategy in Canada with respect to incidence, mortality, screening and diagnostic test volumes. PMID: 26985148 [PubMed] (Source: Current Oncology)



Inflammatory microenvironment and human papillomavirus-induced carcinogenesis

Sat, 19 Mar 2016 00:00:00 +0100

The seminal observations linking inflammation and cancers dated back to mid nineteenth century when Virchow noticed that tumors tended to occur at sites of chronic inflammation. The hypothesis of a connection between inflammation and cancer was subsequently challenged by data demonstrating that acute inflammation contributed to cancer regression, even if epidemiologic studies supported that chronic inflammatory diseases are frequently associated with increased risk of cancers [1]. Nowadays, it has been realized that the development of cancers from inflammation might be a process driven by inflammatory cells as well as a variety of mediators, including cytokines, chemokines and enzymes, which altogether establish an inflammatory microenvironment [1]. (Source: Cytokine and Growth Factor Revi...



Detection of human papillomavirus type 124 in a viral wart located on a thigh

Sat, 19 Mar 2016 00:00:00 +0100

(Source: The Journal of Dermatology)

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Low‐ and high‐risk human papillomavirus genotype infections in intra‐anal warts in HIV‐positive men‐who‐have‐sex‐with‐men

Sat, 19 Mar 2016 00:00:00 +0100

ConclusionsLow‐grade AIN lesions can be caused by high‐risk HPV genotypes and vice versa. We therefore recommend for HIV‐positive MSM routine follow‐up and treatment of all dysplastic intra‐anal warts.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)



Rates of Human Papillomavirus Vaccine Uptake amongst Girls Five Years after Introduction of Statewide Mandate in Virginia

Sat, 19 Mar 2016 00:00:00 +0100

This study assesses the impact that it has had on the rates of HPV uptake. (Source: American Journal of Obstetrics and Gynecology)



Human Papillomavirus and Head and Neck Cancer: Psychosocial Impact in Patients and Knowledge of the Link – A Systematic Review

Sat, 19 Mar 2016 00:00:00 +0100

Head and neck cancer (HNC) currently affects approximately 11 200 people in the UK, with an increasing proportion known to be caused by the human papillomavirus (HPV). We undertook a systematic review of studies measuring the psychosocial impact of HPV-related HNC and also studies measuring knowledge about the link between HPV and HNC among different populations. Searches were conducted on MEDLINE, Embase, PsycINFO, CINAHL Plus and Web of Science, with reference and forward citation searches also carried out on included studies. (Source: Clinical Oncology)



Low- and high-risk human papillomavirus genotype infections in intra-anal warts in HIV-positive men-who-have-sex-with-men.

Sat, 19 Mar 2016 00:00:00 +0100

CONCLUSIONS: Low-grade AIN lesions can be caused by high-risk HPV genotypes and vice versa. We therefore recommend for HIV-positive MSM routine follow-up and treatment of all dysplastic intra-anal warts. This article is protected by copyright. All rights reserved. PMID: 26994411 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)



Spontaneous Remission of Recalcitrant Warts in Girls After Human Papillomavirus Vaccination.

Fri, 18 Mar 2016 23:00:00 +0100

Authors: Martín JM, Escandell I, Ayala D, Jordá E PMID: 27006016 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)

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Focal Epithelial Hyperplasia (Heck's Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review.

Fri, 18 Mar 2016 20:38:02 +0100

This article describes a case of FEH in a 57-year-old Brazilian patient presenting since childhood, with multiple lesions in the lips, buccal mucosa and tongue. The solitary tongue lesion underwent excisional biopsy and the histopathological analysis showed parakeratosis, acanthosis, rete pegs with a club-shaped appearance, koilocytosis and the presence of mitosoid cells. These microscopic findings in conjunction with clinical presentation were sufficient to establish the accurate diagnosis of FEH. Polymerase chain reaction (PCR) was performed, but no one human papillomavirus (HPV) subtype could be identified. Clinicians must be aware of this rare oral disease, which can even affect elderly patients, as we described here. Treatment may be indicated in selected cases due to esthetic and/or ...



Impact of HPV sample self-collection for underscreened women in the renewed Cervical Screening Program.

Fri, 18 Mar 2016 17:23:01 +0100

CONCLUSIONS: Offering HPV self-collection has the potential to considerably improve outcomes for unscreened and underscreened women. Nevertheless, these findings underscore the need for concerted strategies to encourage these women to join the mainstream HPV screening program. PMID: 26985849 [PubMed - as supplied by publisher] (Source: Med J Aust)



Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors

Fri, 18 Mar 2016 00:00:00 +0100

Conclusion HPV-positive OPSCCs with a low count of CD3+ TILs or high expression of SERPINB1 have a worse OS, comparable with HPV-negative OPSCCs. This suggests that the immune system plays an important role in the carcinogenesis of the virally induced oropharynx tumors. (Source: Cancer Immunology, Immunotherapy)



Human Papillomavirus‐Related Oropharyngeal Cancer in Women

Fri, 18 Mar 2016 00:00:00 +0100

This article discusses the etiology and clinical presentation of HPV‐positive and HPV‐negative oropharyngeal cancer, noting distinctions between the 2 types. Recommendations for screening and prevention are provided. (Source: Journal of Midwifery and Women's Health)



Cytomegalovirus and Mucoepidermoid carcinoma: A possible causal relationship? A pilot study.

Thu, 17 Mar 2016 17:22:02 +0100

CONCLUSION: The purpose of the study was to explore the role of CMV in the development of MEC, as it might help to exploit this etiological agent as a therapeutic target. Similar to human papillomavirus (HPV), these might identify a subset of neoplasms with a varied biological behavior and alternative therapies. However, this vision is obscured by contradicting evidence in the literature. As of today, surgery remains the only best possible management for these patients unless proven otherwise. PMID: 26980959 [PubMed] (Source: Journal of Oral and Maxillofacial Pathology)

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Hybrid Capture 2 and cobas human papillomavirus assays perform similarly on SurePath samples from women with abnormalities

Thu, 17 Mar 2016 13:07:16 +0100

ConclusionsIn women with the studied well‐defined clinical indications for HPV testing, cobas and HC2 performed similarly in terms of the detection of HPV and ≥CIN2. (Source: Cytopathology)



The budget impact of cervical cancer screening using HPV primary screening.

Thu, 17 Mar 2016 11:50:01 +0100

CONCLUSIONS: Primary HPV screening with genotyping represents a sensible combination of clinical effectiveness and costs, while reducing the risks associated with patient noncompliance. PMID: 26978241 [PubMed - in process] (Source: The American Journal of Managed Care)



Genotyping and follow-up of HR-HPV types detected by self-sampling in women from low socioeconomic groups not participating in regular cervical cancer screening in France

Thu, 17 Mar 2016 00:00:00 +0100

High-risk oncogenic human papillomavirus (HR-HPV) infection is the major cause for the development of cervical cancer and cervical intraepithelial neoplasia (CIN) [1]. Cervical cancer is the second most common cancer among women worldwide whereas in France, 3000 new cases of cervical cancer are detected each year, leading to 1102 deaths per year [2]. In France, cytological screening is not organized systematically at the country-wide level and it is recommended every 3 years in 25–65 years old women following 2 normal cytological exams. (Source: Journal of Clinical Virology)



Human papillomavirus detection in a “Digital” age

Thu, 17 Mar 2016 00:00:00 +0100

It is increasingly important to identify the presence of human papillomavirus (HPV) in patients with oropharyngeal squamous cell carcinoma, because HPV status is now useful for clinical trial stratification, prognostic determination, diagnosis in patients with neck masses, and identification of the primary tumor site. Therefore, it is important that the technique used for identification be feasible, accurate, reproducible, and cost effective. The authors summarize these aspects of HPV detection and the use of newer digital polymerase chain reaction technology for this purpose. See also pages. (Source: Cancer)



Detection of human papillomavirus type 16 in oropharyngeal squamous cell carcinoma using droplet digital polymerase chain reaction

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONSThe ddPCR of HPV E6/E7 is a novel and highly specific method of detecting HPV‐16 in OPSCC. Cancer 2016. © 2016 American Cancer Society. (Source: Cancer)

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Antibody responses following incident anal and penile infection with human papillomavirus in teenage men who have sex with men

Thu, 17 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



Urine testing to monitor the impact of HPV vaccination in Bhutan and Rwanda

Thu, 17 Mar 2016 00:00:00 +0100

In conclusion, our study supports the feasibility of urine surveys to monitor HPV vaccination and quantifies the effectiveness of the quadrivalent vaccine in women vaccinated after pre‐adolescence. Future similar surveys should detect increases in vaccine effectiveness if vaccination of 12 year‐olds continues. This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



Use of swabs for dry collection of self-samples to detect human papillomavirus among Malagasy women

Thu, 17 Mar 2016 00:00:00 +0100

Most women in developing countries have never attended cervical screening programmes and often little information exists on type-specific human papillomavirus (HPV) prevalence among these populations. Self-sam... (Source: Infectious Agents and Cancer)



Cervical cancer stem cells selectively overexpress HPV oncoprotein E6 that controls stemness and self renewal through upregulation of HES1.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: Our findings suggest the possible mechanism by which HPVE6 potentially regulate and maintain stem-like cancer cells through Hes1. PMID: 26988248 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)



Prevention of cervical cancer: journey to develop the first human papillomavirus virus-like particle vaccine and the next generation vaccine.

Thu, 17 Mar 2016 00:00:00 +0100

Authors: Bryan JT, Buckland B, Hammond J, Jansen KU Abstract In 2006, the first human papillomavirus (HPV) virus-like particle (VLP) vaccine was licensed. Gardasil(®), the quadrivalent HPV 6, 11, 16 and 18 recombinant VLP vaccine (4vHPV), developed by Merck demonstrated remarkable efficacy in prevention of important clinical pre-cursors to cervical cancer and genital warts. The vaccine was designed to protect against HPV 16 and 18 that cause ∼70% of cervical cancers and HPV 6 and 11 that cause ∼90% of genital warts. Initially, Gardasil(®) was indicated in the United States for women 9-26 years of age for the prevention of HPV 16 and 18-related cervical, vulvar and vaginal cancer, HPV 6, 11, 16 and 18-related genital intraepithelial neoplasia and the prevention of HPV 6 and 11...

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Large Cell Neuroendocrine Carcinoma of the Head and Neck: A Clinicopathologic Series of 10 Cases With an Emphasis on HPV Status

Wed, 16 Mar 2016 00:34:36 +0100

Large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine neoplasm first described in the lung and subsequently well documented in many other anatomic sites. It has only recently been recognized that LCNEC can also occasionally arise in the head and neck. The role of human papillomavirus (HPV), which is associated with some small cell carcinomas of the head and neck, has not been investigated for LCNEC. We sought to further characterize the histologic, immunophenotypic, and clinical features of LCNEC and also investigate the role of HPV in this newly described group of tumors. The surgical pathology archives of 2 large academic institutions were searched for cases of LCNEC arising in the head and neck. p16 immunohistochemistry and HPV in situ hybridization were performed, ...



Lower Female Genital Tract Tumors With Adenoid Cystic Differentiation: P16 Expression and High-risk HPV Detection

Wed, 16 Mar 2016 00:34:36 +0100

Lower female genital tract tumors with adenoid cystic differentiation are rare, and data on their relationship with high-risk human papillomavirus (HPV) are limited. Here we report the clinicopathologic features from a case series. Tumors with adenoid cystic differentiation, either pure or as part of a carcinoma with mixed differentiation, arising in the lower female genital tract were evaluated by means of immunohistochemical analysis for p16 expression and in situ hybridization using 1 or more probes for high-risk HPV (a high-risk probe covering multiple types, a wide-spectrum probe, and separate type-specific probes for HPV16 and HPV18) and when possible by polymerase chain reaction for high-risk HPV. Six cervical carcinomas with adenoid cystic differentiation admixed with various combi...



Physicians' Communication About Human Papillomavirus Vaccination Is Often Deficient

Wed, 16 Mar 2016 00:00:00 +0100

(Source: Perspectives on Sexual and Reproductive Health)



Cancer-causing HPV plummeted in teens since vaccine, study finds

Tue, 15 Mar 2016 20:02:03 +0100

The human papillomavirus vaccine was first recommended for adolescent girls in the United States in 2006. Since that time, the prevalence of the cancer-causing virus has been dropping among young women, according to a new study. (Source: CNN.com - Health)



Cuba Has Made At Least 3 Major Medical Innovations That We Need

Tue, 15 Mar 2016 18:36:31 +0100

By most measures, the United States' business-friendly environment has proven to be fertile for medical innovation. Compared to other countries, America has filed the most patents in the life sciences, is conducting most of the world's clinical trials and has published the most biomedical research. That's what makes the medical prominence of Cuba all the more surprising to those who view a free market as an essential driver of scientific discovery. Cuba is very poor, and yet the country has some of the healthiest, most long-lived residents in the world -- as well as a medical invention or two that could run circles around U.S. therapies, thanks to government investment in scientific research and a preventive public health approach that views medical care as a birthright. The isla...

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Efficacy of intralesional immunotherapy for the treatment of warts: A review of the literature

Tue, 15 Mar 2016 00:00:00 +0100

ABSTRACT Warts are common epidermal growths caused by human papillomavirus that often cause significant discomfort and embarrassment. Current treatment options include topical therapies, cryotherapy, laser vaporization, and surgical excision. Many of these options are destructive and may result in scarring, while less aggressive approaches can lead to lesion recurrence. Additionally, these local modalities are not practical for patients with a large number of warts. Systemic approaches such as immunotherapy have demonstrated success in treating multiple lesions by combining a targeted approach with upregulation of the host immune system. An extensive literature review was performed to evaluate the various vaccine antigens that have been used intralesionally to treat cutaneous and anogenita...



Origin of cystic squamous cell carcinoma metastases in head and neck lymph nodes: Addition of EBV testing improves diagnostic accuracy

Tue, 15 Mar 2016 00:00:00 +0100

Publication date: Available online 14 March 2016 Source:Pathology - Research and Practice Author(s): Marián Švajdler, Jana Kašpírková, Ladislav Hadravský, Jan Laco, Pavol Dubinský, Ľubomír Straka, Ondrej Ondič, Michal Michal, Alena Skálová Most cases of cystic squamous cell carcinoma (SCC) metastases in the upper neck are associated with an oropharyngeal primary, namely human papillomavirus (HPV)-associated SCC arising in the palatine or lingual tonsil. A retrospective study was performed on 22 patients who presented with cystic head and neck SCC metastases. The purpose of the study was to find out whether histological characteristics, p16 protein expression, HPV and Epstein-Barr virus (EBV) status could be useful in predicting the localization of the primary tumor. ...



Sourcing of the WHO Human Papillomavirus type 18 International Standards for HPV antibody levels

Tue, 15 Mar 2016 00:00:00 +0100

Persistent human papillomavirus (HPV) infection is established as a necessary cause for cervical, anogenital and oropharyngeal cancers [1,2]. Most genital HPV infections are transient and clear within 6–12 months [3]. Therefore, HPV DNA testing cannot measure cumulative HPV exposure. The antibody responses to the HPV capsid are known to be stable over time, providing a useful measure of cumulative HPV exposure [4]. (Source: Journal of Clinical Virology)



Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination

Tue, 15 Mar 2016 00:00:00 +0100

Abstract In the dose-escalation phase of a Phase I clinical trial in which six subjects each were vaccinated with PepCan at the 50, 100, 250, and 500 μg per peptide dose, the 50 μg dose showed the best histological regression rate. Ten additional subjects were vaccinated at this dose in the final dose phase. As with the dose-escalation phase, no dose-limiting toxicities were observed. Overall, the histological regression rates were 50 % at the 50 μg dose (7 of 14) and 100 μg dose (3 of 6), and 45 % overall (14 of 31). Of subjects in whom HPV type 16 (HPV 16) was detected at entry, it became undetectable in three subjects after vaccination, and the viral loads significantly decreased in nine subjects in whom HPV 16 infection was detected at entry and exit (p = 0.008). I...



MGMT Hypermethylation—Missing Piece of the Puzzle in Primary Head and Neck Squamous Cell Carcinoma?

Tue, 15 Mar 2016 00:00:00 +0100

A secific mechanism explaining the higher chemoradiation responsiveness of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) and the modulation of this effect by tobacco exposure remains unidentified. Promoter hypermethylation (HM) of the DNA-repair O6-Methylguanine (O6-MG)-DNA-methyl-transferase (MGMT) gene is an independent predictor of response to chemoradiation and survival in gliomas and lymphomas. We are investigating the role of MGMT in HNSCC in the context of tobacco exposure and HPV status. (Source: International Journal of Radiation Oncology * Biology * Physics)

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CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study.

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Santos EU, Lima GD, Oliveira ML, Heráclio SA, Silva HD, Crovella S, Maia MM, Souza/ PR Abstract Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) and CCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervica...



A Contemporary Review of HPV and Penile Cancer.

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Stratton KL, Culkin DJ Abstract Human papillomavirus (HPV) is a widespread sexually transmitted infection. In both men and women, HPV infection can result in a spectrum of genitourinary manifestations ranging from genital warts to cancer. Cervical cancer is nearly always associated with high-risk HPV infection. For men, penile cancer can develop following or independently of HPV infection. Basaloid and warty subtypes of penile squamous cell carcinoma are most frequently associated with HPV infection. Further research into the molecular alterations caused by HPV infection may provide prognostic markers and future treatment targets. Until an effective treatment for HPV infection is developed, prevention will remain the focus of disease control. For women, vaccination is incr...



HPV vaccination protects high-risk girls from cervical cancer

Mon, 14 Mar 2016 15:00:00 +0100

Full or partial vaccination with the quadrivalent human papillomavirus vaccine reduced the overall risk of abnormal cervical pathology by 36%, based on data from a retrospective cohort study of just... (Source: Pediatric News)



Viruses, Vol. 8, Pages 79: Characterization of Intra-Type Variants of Oncogenic Human Papillomaviruses by Next-Generation Deep Sequencing of the E6/E7 Region

Mon, 14 Mar 2016 00:00:00 +0100

In this study, we designed and validated a new method based on multiplex PCR-deep sequencing of the E6/E7 region of HR-HPV types to characterize HPV intra-type variants in clinical specimens. Validation experiments demonstrated that this method allowed reliable identification of the different lineages of oncogenic HPV types. Advantages of this method over other published methods were represented by its ability to detect variants of all HR-HPV types in a single reaction, to detect variants of HR-HPV types in clinical specimens with multiple infections, and, being based on sequencing of the full E6/E7 region, to detect amino acid changes in these oncogenes potentially associated with increased transforming activity. (Source: Viruses)

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Toll‐like receptor 2 gene polymorphisms in Korean women with human papillomavirus‐related cervical neoplasia

Mon, 14 Mar 2016 00:00:00 +0100

ConclusionsOur study provides the first evidence that TLR2 gene polymorphisms are associated with high‐risk type HPV‐related cervical neoplasia and may play an important role in susceptibility to HPV infection. Further large‐scale and functional studies are needed to confirm the role of TLR2 gene polymorphisms in HPV‐related cervical neoplasia.This article is protected by copyright. All rights reserved. (Source: Acta Obstetricia et Gynecologica Scandinavica)



Human Papillomavirus Vaccination Among Low-Income Minority Females

Mon, 14 Mar 2016 00:00:00 +0100

This cohort study examines the effect of human papillomavirus vaccination on the subsequent risk for abnormal cervical cytology results among urban, low-income minority females. (Source: JAMA Pediatrics)



Transoral Surgery or Radiotherapy for Oropharyngeal Carcinoma – Is It Either Or…?

Mon, 14 Mar 2016 00:00:00 +0100

The management of oropharyngeal carcinoma represents an increasing clinical challenge, because of its rising incidence, particularly in younger patients as a result of human papillomavirus (HPV) infection, and because significant technological advances have occurred in radiotherapy and surgery over the last 10 years that have increased treatment options for patients, with little robust evidence yet of their relative merits. As a result, there is a lack of clinical consensus on the optimum treatment modality, reflected in wide variation in practice between different cancer networks across the UK. (Source: Clinical Oncology)



Human papillomavirus infection and risk of breast cancer: a meta-analysis of case-control studies

Mon, 14 Mar 2016 00:00:00 +0100

Although systematic reviews (SR) report that human papillomavirus (HPV) increases the risk of breast cancer, there are still disputes regarding this association. In particular, it has been argued that the risk... (Source: Infectious Agents and Cancer)



Origin of cystic squamous cell carcinoma metastases in head and neck lymph nodes: Addition of EBV testing improves diagnostic accuracy.

Sun, 13 Mar 2016 23:00:00 +0100

Authors: Švajdler M, Kašpírková J, Hadravský L, Laco J, Dubinský P, Straka Ľ, Ondič O, Michal M, Skálová A Abstract Most cases of cystic squamous cell carcinoma (SCC) metastases in the upper neck are associated with an oropharyngeal primary, namely human papillomavirus (HPV)-associated SCC arising in the palatine or lingual tonsil. A retrospective study was performed on 22 patients who presented with cystic head and neck SCC metastases. The purpose of the study was to find out whether histological characteristics, p16 protein expression, HPV and Epstein-Barr virus (EBV) status could be useful in predicting the localization of the primary tumor. The primary site was identified in 20 of 22 patients and included the oropharynx in 14 patients (63.6%), the nasopharynx in 3 pat...

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Race Is Associated With Sexual Behaviors and Modifies the Effect of Age on Human Papillomavirus Serostatus Among Perimenopausal Women

Sun, 13 Mar 2016 19:07:07 +0100

Conclusions: Racial differences in immune markers of HPV exposure and the epidemiology of HPV-related cancers may be linked to differences in patterns of sexual behaviors. (Source: Sexually Transmitted Diseases)



Significant Reduction in the Incidence of Genital Warts in Young Men 5 Years Into the Danish Human Papillomavirus Vaccination Program for Girls and Women

Sun, 13 Mar 2016 19:07:07 +0100

Conclusions: We found a significantly decreasing incidence of GWs in women up to 35 years of age after the start of the human papillomavirus vaccination program. A similar pattern was observed for men aged 12 to 29 years, indicating substantial herd protection. (Source: Sexually Transmitted Diseases)



Prevalence of Anal High-Risk Human Papillomavirus Infections Among HIV-Positive and HIV-Negative Men Who Have Sex With Men in Nigeria

Sun, 13 Mar 2016 19:07:07 +0100

Conclusions: Anal HR-HPV infection is high for young Nigerian MSM, and rates are amplified in those coinfected with HIV. Providing universal coverage as well as catch-up immunization for young MSM may be an effective anal cancer prevention strategy in Nigeria. (Source: Sexually Transmitted Diseases)



The potential harms of primary human papillomavirus screening in over-screened women: a microsimulation study

Sat, 12 Mar 2016 00:00:00 +0100

Conclusion For over-screened women, the harms associated with a lower test specificity outweigh the life years gained when switching from primary cytology to primary HPV testing. The extent of over-screening should be considered when deciding on inclusion of primary HPV screening in cervical cancer screening guidelines. (Source: Cancer Causes and Control)



Treatment of Imiquimod Resistant Epidermodysplasia Verruciformis With Ingenol Mebutate.

Fri, 11 Mar 2016 11:29:03 +0100

CONCLUSION: Our case provides insight into the potential use of ingenol mebutate for EV patients unresponsive to traditional medical treatments.

J Drugs Dermatol. 2016;15(3):350-352. PMID: 26954321 [PubMed - in process] (Source: Journal of Drugs in Dermatology)

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Predictors of overall survival in human papillomavirus-associated oropharyngeal cancer using the National Cancer Data Base

Fri, 11 Mar 2016 00:00:00 +0100

In the United States, approximately 40–80% of oropharynx squamous cell cancers (OPSCC) are caused by human papillomavirus (HPV) [1]. While the overall incidence of head and neck SCC in the United States is declining, the rate of HPV-associated OPSCC appears to be rising [2]. In fact, the Centers for Disease Control and Prevention (CDC) found that OPSCC were one of only five cancers increasing in incidence from 1975 to 2009 [3]. Clinically, HPV-positive cancers typically arise in the lingual and palatine tonsils, are poorly differentiated, have lower tumor (T) stage with more advanced nodal (N) stage and affect younger, white males [4]. (Source: Oral Oncology)



Epidemiology of Low-Risk Human Papillomavirus

Fri, 11 Mar 2016 00:00:00 +0100

Abstract Infection with low-risk human papillomaviruses (HPVs), mostly type 6 and 11, in the upper respiratory tract causes recurrent respiratory papillomatosis (RRP). Despite a relatively low incidence rate, RRP imposes significant morbidity upon affected patients and an enormous financial burden on the healthcare system. RRP can be further categorized into juvenile-onset RRP and adult-onset RRP, depending on the onset age. They may associate with different risk factors and incidence rates. Here, we review the epidemiology of RRP caused by low-risk HPV infection and discuss the impact of HPV vaccination on the prevalence of low-risk HPVs that cause RRP. (Source: Current Otorhinolaryngology Reports)



Human papillomavirus in tonsillar squamous cell carcinomas from Guatemala and Brazil

Fri, 11 Mar 2016 00:00:00 +0100

Conclusions Cases from Guatemala, which were mostly nonkeratinizing SCC and originated from the crypt/reticular epithelium of the tonsil, had high-risk integrated HPV, whereas in Brazilian cases, which were mostly keratinizing SCC that originated from the surface epithelium, there was no association with HPV. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)



Reproductive Tract infections and Premalignant Lesions of Cervix: Evidence from Women Presenting at the Cancer Detection Centre of the Indian Cancer Society, Delhi, 2000–2012

Fri, 11 Mar 2016 00:00:00 +0100

Conclusions Earlier studies have depicted associations between TV and HPV with possible enhancement of HPV virulence due to TV. Lack of awareness and hygiene, and limited access to gynecologists in LMICs lead to frequent and persistent RTIs which aid and abet HPV infection and CC occurrence. These also need to be addressed to reduce CC and RTIs among women in LMICs. (Source: The Journal of Obstetrics and Gynecology of India)



Hope in the Long Road Toward the Development of a Therapeutic Human Papillomavirus Vaccine.

Fri, 11 Mar 2016 00:00:00 +0100

Authors: Karaki S, Pere H, Badoual C, Tartour E Abstract A pool of long synthetic peptides derived from HPV16 proteins induce objective partial or complete histological regression of lesions in more than 50% of patients with high-grade vulvar (VuVIN3) and vaginal intraepithelial neoplasia (VaIN3). The intensity of T cell response induced by the vaccine was correlated with clinical response. PMID: 26968203 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Multiple Human Papillomavirus Infection Is Associated with High-Risk Infection in Male Genital Warts in Ulsan, Korea.

Thu, 10 Mar 2016 16:16:02 +0100

Authors: Kwon T, Moon KH, Yang SH, Roh MC, Lee SH, Kim JW, Kim IK, Roh KH, Park S Abstract Further understanding of male human papillomavirus (HPV) infection is necessary to prevent infection in men, as well as transmission to women. In our current study, we investigated patterns of HPV infection and genotype distributions in male genital warts using the Anyplex II HPV28 Detection kit. We reviewed the medical records of 80 male patients who presented to 5 neighborhood clinics in Ulsan, Korea, for the treatment of genital warts between April 2014 and January 2015. All patients underwent HPV genotyping. The prevalence and characteristics of HPV infection were analyzed, and the patterns of HPV infection according to age were assessed. Among the study patients, 13 (16.3%) were negative...



Health service utilisation for anogenital warts in Ontario, Canada prior to the human papillomavirus (HPV) vaccine programme introduction: a retrospective longitudinal population-based study

Thu, 10 Mar 2016 00:00:00 +0100

Conclusions To the best of our knowledge, this is the first population-based study of AGW incidence and HSU in Ontario. The sex and age distribution of individuals with incident and prevalent AGWs in Ontario was similar to that of other provinces before HPV vaccine programme implementation in Canada. (Source: BMJ Open)



Detection of Merkel cell polyomavirus and Human papillomavirus DNA in porocarcinoma

Thu, 10 Mar 2016 00:00:00 +0100

Porocarcinoma is a malignant epithelial tumour originating from or differentiating toward the intraepidermal eccrine duct (i.e. acrosyringium). Although considered the most frequent sweat gland carcinoma, the tumour is relatively rare, representing 0,005–0,01% of epithelial cutaneous neoplasms [1]. However, it is possible that the real incidence is underestimated, because of the difficult clinicopathologic distinction from the more acquainted squamous cell carcinoma [2,3]. About 20% of porocarcinomas can recur and metastasize to regional lymph nodes and rarely to distant organs; mortality rate has been estimated as high as 67% of patients with nodal metastases [4]. (Source: Journal of Clinical Virology)



[Teledermatology in a prison setting: A retrospective study of 500 expert opinions].

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSION: This study provides greater knowledge of dermatological diseases in prison and shows teledermatology to be a tool suited to the specific constraints of this universe, while providing inmates with medical care as close as possible to that of the general population, and it thus helps ensure that their fundamental human rights are upheld. PMID: 26971370 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)



Mayo Clinic Minute: HPV Vaccine Prevents Cancer

Thu, 10 Mar 2016 00:00:00 +0100

Earlier this month we reported on the big drop in rates of human papillomavirus (HPV) infection in the United States. A study in the journal Pediatrics shows that since the introduction of the HPV vaccine six years ago, the rate of HPV infection has dropped 64 percent for girls ages 14 to 19. The Centers for [...] (Source: News from Mayo Clinic)

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