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MedWorm: Chlamydia



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Chlamydia category.



Last Build Date: Tue, 22 Mar 2016 08:25:40 +0100

 



Extended semen for artificial insemination in swine as a potential transmission mechanism for infectious Chlamydia suis

Sat, 19 Mar 2016 00:00:00 +0100

Though typically unnoticed, Chlamydia infections in swine have been shown to be both wide-spread and may impact production characteristics and reproductive performance in swine. Serum titers suggest Chlamydia infection within boar studs is common and infected boars are known to shed chlamydia in their ejaculates. While the transmission of viruses in chilled extended semen is well established, the inclusion of antibiotics in commercially available extender is generally believed to limit or preclude the transmission of infectious bacteria. (Source: Theriogenology)

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Prevalence of plasmid-bearing and plasmid-free Chlamydia trachomatis infection among women who visited obstetrics and gynecology clinics in Malaysia

Fri, 18 Mar 2016 00:00:00 +0100

The 7.5 kb cryptic plasmid of Chlamydia trachomatis has been shown to be a virulence factor in animal models, but its significance in humans still remains unknown. The aim of this study was to investigate the pre... (Source: BMC Microbiology)



Chlamydia trachomatis Pgp3 Antibody Persists and Correlates with Self-Reported Infection and Behavioural Risks in a Blinded Cohort Study

Mon, 14 Mar 2016 00:00:00 +0100

Chlamydia trachomatis (Ct) serological studies in populations could help monitor changes in lifetime cumulative risk of infection. We developed a double-antigen sandwich ELISA based on the Ct-specific Pgp3 antigen, then tested blind stored sera from over 800 participants in a New Zealand birth cohort from Dunedin at ages 26, 32 and 38. The double-antigen sandwich ELISA was more sensitive than our previously characterised indirect Pgp3 ELISA. Pgp3 antibody was detected more often in women compared to men and correlated with increasing numbers of sexual partners, self-reported Ct, and younger age at sexual debut in both women and men. At age 26, 24.1% (99/411) of women were Pgp3 seropositive, as were 79.5% (35/44) of those reporting Ct infection; Pgp3 antibody persisted to age 38 in 96.5% (8...



Sensitivity of the Standard Chlamydia trachomatis Culture Method Is Improved After One Additional In Vitro Passage

Mon, 14 Mar 2016 00:00:00 +0100

ConclusionThe results of this study support the use of a three‐passage Chlamydia culture procedure to increase the detection sensitivity of this method. (Source: Journal of Clinical Laboratory Analysis)



In vitro activity of quaternary ammonium surfactants against streptococcal, chlamydial, and gonococcal infective agents.

Mon, 14 Mar 2016 00:00:00 +0100

Authors: Inácio ÂS, Nunes A, Milho C, Mota LJ, Borrego MJ, Gomes JP, Vaz WL, Vieira OV Abstract Quaternary ammonium compounds (QAC) are widely used, cheap, and chemically stable disinfectants and topical antiseptics with wide spectrum antimicrobial activities. Within this group of compounds, we recently showed that there are significant differences between the pharmacodynamics of n-alkyl quaternary ammonium surfactants (QAS) with a short (C12) alkyl chain when in vitro toxicities towards bacterial and mammalian epithelial cells are compared. These differences result in an attractive therapeutic window that justifies studying short-chain QAS as prophylactics for sexually transmitted infections (STI) and perinatal vertically transmitted urogenital infections (UGI). We have evaluate...



Screening for Asymptomatic Gonorrhea and Chlamydia in the Pediatric Emergency Department

Sun, 13 Mar 2016 19:07:07 +0100

Conclusions: There are high proportions of GC and CT among asymptomatic adolescents visiting an academic urban PED. A universal PED STI screening program may be an important component of STI reduction initiatives, especially among adolescents who do not perceive that they are at risk and may not receive testing elsewhere. (Source: Sexually Transmitted Diseases)

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Access to chlamydia testing in remote and rural Scotland.

Sat, 12 Mar 2016 04:43:02 +0100

CONCLUSIONS: These results are similar to previous results in other countries that suggest that Chlamydia positivity is similar in rural and urban settings. A large proportion of people living in more rurally classified areas, and perhaps those with a higher risk, have their test in a central setting, suggesting that they may be bypassing local resources to get a test. The reason for this is not clear. The results also show that men are more likely to have their test in a genitourinary setting as well as have proportionately more positive results. These results support the case for customising sexual health services to the most rural areas and suggest that providing an anonymous testing service in these areas might be beneficial, especially for men. PMID: 26961815 [P...



Pelvic Examination at the 6‐Week Postpartum Visit After Cesarean Birth

Fri, 11 Mar 2016 00:00:00 +0100

The objective of this study was to assess the utility of the pelvic examination at the 6‐week postpartum visit after cesarean birth. MethodsData were collected from retrospective chart review in an obstetric resident clinic in Detroit, Michigan. Women included were those who had a cesarean birth between January 2012 and June 2014. ResultsOf 388 women who had a cesarean birth, 211 (54.4%) presented for the 6‐week postpartum visit and underwent pelvic examination. Of these women, 185 (87.7%) were asymptomatic, and 26 (12.3%) reported vaginal discharge. No other concerns were elicited. Of those with symptoms, 4 (15%) had no finding, 13 (50%) had bacterial vaginosis (BV) alone, 2 (8%) had BV and Candida sp, 2 (8%) had BV and Trichomonas vaginalis, 2 (8%) had T vaginalis alone, and 3 (11%) ...



Screening for asymptomatic urogenital Chlamydia trachomatis infection at a large Dublin maternity hospital: results of a pilot study

Fri, 11 Mar 2016 00:00:00 +0100

Conclusions The prevalence rate of detected C. trachomatis infection was 5.6 % in the study population. Screening of antenatal patients may have a role in preventing vertical transmission of infection to the neonate. (Source: Irish Journal of Medical Science)



Prevalence of Trichomonas vaginalis in Women Visiting 2 Obstetrics and Gynecology Clinics in Daegu, South Korea.

Thu, 10 Mar 2016 18:29:02 +0100

This study explored epidemiological trends in trichomoniasis in Daegu, South Korea. Wet mount microscopy, PCR, and multiplex PCR were used to test for Trichomonas vaginalis in vaginal swab samples obtained from 621 women visiting 2 clinics in Daegu. Of the 621 women tested, microscopy detected T. vaginalis in 4 (0.6%) patients, PCR detected T. vaginalis in 19 (3.0%) patients, and multiplex PCR detected T. vaginalis in 12 (1.9%) patients. Testing via PCR demonstrated high sensitivity and high negative predictive value for T. vaginalis. Among the 19 women who tested positive for T. vaginalis according to PCR, 94.7% (18/19) reported vaginal signs and symptoms. Notably, more than 50% of T. vaginalis infections occurred in females younger than 30 years old, and 58% were unmarried. Multiplex PCR...



ECDC publishes updated evidence-based guidance for chlamydia prevention and control and makes latest chlamydia figures available online through interactive Surveillance Atlas

Thu, 10 Mar 2016 00:00:00 +0100

(Source: Eurosurveillance)

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Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii

Thu, 10 Mar 2016 00:00:00 +0100

This study highlights fundamental differences between human and murine GBPs and underlines the need to study the functions of GBPs at cellular locations away from PVs. (Source: Cellular Microbiology)



ECDC publishes updated evidence-based guidance for chlamydia prevention and control and makes latest chlamydia figures available online through interactive Surveillance Atlas.

Thu, 10 Mar 2016 00:00:00 +0100

Authors: Mardh O, Amato-Gauci AJ PMID: 26987679 [PubMed - in process] (Source: Euro Surveill)



Temporal proteomic profiling of Chlamydia trachomatis–infected HeLa‐229 human cervical epithelial cells

Tue, 08 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Proteomics)



Guinea pig genital tract lipidome reveals in vivo and in vitro regulation of phosphatidylcholine 16:0/18:1 and contribution to Chlamydia trachomatis serovar D infectivity

Tue, 08 Mar 2016 00:00:00 +0100

Conclusion This study demonstrates a role for host metabolite, PC 16:0/18:1 in regulating genital Ct infection in vivo and in vitro. (Source: Metabolomics)



Detection of Chlamydia trachomatis and Neisseria gonorrhoeae based on cross‐priming amplification (CPA)

Mon, 07 Mar 2016 00:00:00 +0100

This study demonstrated that CPA is an affordable and accessible assay for C. trachomatis and N. gonorrhoeae detection, with high sensitivity and specificity. This article is protected by copyright. All rights reserved. (Source: Letters in Applied Microbiology)

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Cost-Effectiveness of Opt-Out Chlamydia Testing for High-Risk Young Women in the U.S.

Sun, 06 Mar 2016 00:00:00 +0100

Conclusions The proposed Opt-Out Testing strategy was cost saving, improving health outcomes at a lower net cost than current testing. However, testing gaps would remain because many women might not have health insurance coverage, or not utilize health care. (Source: American Journal of Preventive Medicine)



Treatment with everolimus for a patient with systemic metastatic breast cancer results in severe pulmonary injury: a case report.

Sat, 05 Mar 2016 12:13:02 +0100

This study reports that treatment with everolimus alone induced severe pulmonary injury in a patient with systemic metastatic breast cancer. A 58-yearold woman with systemic metastatic breast cancer was treated with everolimus alone for 4 weeks and developed severe cough and dyspnea. Computed tomography (CT) scan of the chest showed a progressive lung tumor accompanied by bilateral pulmonary homogeneous ground-glass opacity, especially in the inferior lobe of the left lung. Laboratory examinations revealed a high frequency of monocytes, higher levels of serum alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and C-reactive protein as well as mild hypoxemia and hypocarbia. However, she had no evidence of infection with mycoplasma pneumoniae, chlamydia, pneumocystis, tuberculosis,...



HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from North-East Italy.

Thu, 03 Mar 2016 00:00:00 +0100

Authors: Seraceni S, Campisciano G, Contini C, Comar M Abstract Human papillomavirus (HPV) and Chlamydia trachomatis (CT) are pathogens with oncogenic potential associated with persistent infections. Epidemiological data on CT infection status, CT/HPV co-infection and relationship between HPV genotypes in Italian women are only preliminary.The aim of the present study was to characterize the relationship between HPV genotypes and CT in an extending cohort of asymptomatic immunocompetent women from North-East Italy geographic area. A retrospective study was conducted using Luminex technology, on cervical swabs from asymptomatic immunocompetent women, including 921 attending the prevention centre for Cervical Cancer Program and 6214 who had been referred to the Sexually Transmitted I...



A prospective observational study of vulvovagintis in pregnant women in Argentina, with special reference to candidiasis

Wed, 02 Mar 2016 00:00:00 +0100

In this study, 39.5% of pregnant women had normal microbial biota and symptoms of VV due to non‐infectious causes were observed (6.2%). The occurrence of vulvovaginal candidiasis was 25% and Candida albicans with a prevalence of 80.7% was the dominant species (P = 0.005) while non‐albicans Candida species and other yeast were more common in asymptomatic ones (P = 0.0038). The frequency of bacterial vaginosis, T. vaginalis, C. trachomatis and N. gonorrhoeae were 18.1%, 1.4, 1.4% and 0.5% respectively. (Source: Mycoses)



Chronic Chlamydia pneumoniae lung infection: a neglected explanation for macrolide effects in wheezing and asthma?

Wed, 02 Mar 2016 00:00:00 +0100

Publication date: March 2016 Source:The Lancet Respiratory Medicine, Volume 4, Issue 3 Author(s): David L Hahn, Wilmore Webley (Source: The Lancet Respiratory Medicine)

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Latent Infections as a Risk Factor for Posttrabeculectomy Bleb Failure

Tue, 01 Mar 2016 06:00:00 +0100

Conclusion: Being a contributor to low-grade conjunctival inflammation, latent conjunctival CT, and BF infections in primary open-angle glaucoma patients represent risk factors for posttrabeculectomy bleb failure. (Source: Journal of Glaucoma)



2015 European guideline on the management of Chlamydia trachomatis infections

Tue, 01 Mar 2016 00:00:00 +0100

Chlamydia trachomatis infections, which most frequently are asymptomatic, are major public health concerns globally. The 2015 European C. trachomatis guideline provides: up-to-date guidance regarding broader indications for testing and treatment of C. trachomatis infections; a clearer recommendation of using exclusively-validated nucleic acid amplification tests for diagnosis; advice on (repeated) C. trachomatis testing; the recommendation of increased testing to reduce the incidence of pelvic inflammatory disease and prevent exposure to infection; and recommendations to identify, verify and report C. trachomatis variants. Improvement of access to testing, test performance, diagnostics, antimicrobial treatment and follow-up of C. trachomatis patients are crucial to control its spread. For ...



Identification of unusual Chlamydia pecorum genotypes in Victorian koalas (Phascolarctos cinereus) and clinical variables associated with infection.

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Legione AR, Patterson JL, Whiteley PL, Amery-Gale J, Lynch M, Haynes L, Gilkerson JR, Polkinghorne A, Devlin JM, Sansom FM Abstract Chlamydia pecorum infection is a threat to the health of free-ranging koalas (Phascolarctos cinereus) in Australia. Utilising an extensive sample archive we determined the prevalence of C. pecorum in koalas within six regions of Victoria, Australia. The ompA genotypes of the detected C. pecorum were characterised to better understand the epidemiology of this pathogen in Victorian koalas. Despite many studies in northern Australia (i.e. Queensland and New South Wales), prior Chlamydia studies in Victorian koalas are limited. We detected C. pecorum in 125/820 (15%) urogenital swabs, but in only one ocular swab. Nucleotide sequencing of the molec...



Genotyping and prevalence of Chlamydia trachomatis infection among women in Belém, Pará, northern Brazil

Sun, 28 Feb 2016 08:00:00 +0100

Conclusions: This study emphasizes the relevance of C. trachomatis infection in the young female population of the Brazilian Amazon region. It also demonstrates the diversity of genotypes involved in genital infection in this population. (Source: The Journal of Infection in Developing Countries)



Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics.

Fri, 26 Feb 2016 20:48:02 +0100

Authors: Linnes JC, Rodriguez NM, Liu L, Klapperich CM Abstract Devices based on rapid, paper-based, isothermal nucleic acid amplification techniques have recently emerged with the potential to fill a growing need for highly sensitive point-of-care diagnostics throughout the world. As this field develops, such devices will require optimized materials that promote amplification and sample preparation. Herein, we systematically investigated isothermal nucleic acid amplification in materials currently used in rapid diagnostics (cellulose paper, glass fiber, and nitrocellulose) and two additional porous membranes with upstream sample preparation capabilities (polyethersulfone and polycarbonate). We compared amplification efficiency from four separate DNA and RNA targets (Bordetella per...



Chlamydia bacteria can 'cause tropical disease that leads to loss of vision'

Fri, 26 Feb 2016 04:57:11 +0100

Australian scientists revealed a genetic variation turns the bacteria that causes the STD chlamydia into bacteria (pictured) that causes trachoma, an infectious disease that causes blindness. (Source: the Mail online | Health)



San Francisco officials vote to give condoms to middle schoolers

Fri, 26 Feb 2016 00:26:17 +0100

Health official said in a letter that San Francisco has among the highest rates of chlamydia, gonorrhea and syphilis of any city in the U.S. (Source: Health News: CBSNews.com)



Genomic sequencing reveals link between STIs and leading cause of infectious blindness

Thu, 25 Feb 2016 05:00:00 +0100

(Wellcome Trust Sanger Institute) For the first time, genome sequencing has been carried out on Chlamydia trachomatis, a bacteria responsible for the disease Trachoma -- the world's leading infectious cause of blindness, according to a study in Nature Communications. (Source: EurekAlert! - Infectious and Emerging Diseases)



The "3 in 1" Study: Pooling Self-Taken Pharyngeal, Urethral, and Rectal Samples into a Single Sample for Analysis for Detection of Neisseria gonorrhoeae and Chlamydia trachomatis in Men Who Have Sex with Men [Bacteriology]

Thu, 25 Feb 2016 00:00:00 +0100

Triple-site testing (using pharyngeal, rectal, and urethral/first-void urine samples) for Neisseria gonorrhoeae and Chlamydia trachomatis using nucleic acid amplification tests detects greater numbers of infections among men who have sex with men (MSM). However, triple-site testing represents a cost pressure for services. MSM over 18 years of age were eligible if they requested testing for sexually transmitted infections (STIs), reported recent sexual contact with either C. trachomatis or N. gonorrhoeae, or had symptoms of an STI. Each patient underwent standard-of-care (SOC) triple-site testing, and swabs were taken to form a pooled sample (PS) (pharyngeal, rectal, and urine specimens). The PS was created using two methods during different periods at one clinic, but we analyzed the data i...

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Chlamydia pneumoniae enhances the Th2 profile of stimulated peripheral blood mononuclear cells from asthmatic patients.

Thu, 25 Feb 2016 00:00:00 +0100

Authors: Smith-Norowitz TA, Chotikanatis K, Erstein DP, Perlman J, Norowitz YM, Joks R, Durkin HG, Hammerschlag MR, Kohlhoff S Abstract Chlamydia pneumoniae is a cause of respiratory infection in adults and children. There is evidence for an association between atypical bacterial respiratory pathogens and the pathogenesis of asthma. We compared T helper (Th) responses in C. pneumoniae -infected peripheral blood mononuclear cells (PBMC) in patients with or without asthma. PBMC (1x10(6)/mL) from asthmatic patients (N=11) and non-asthmatic controls (N=12) were infected or mock-infected for 1 hr +/- C. pneumoniae TW-183 at a multiplicity of infection (MOI) =1 and MOI=0.1, or cultured for 24 hr +/- Lactobacillus rhamnosus GG (LGG). Interleukin (IL)-4, IL-10, IL-12, Interferon (IFN)-gamm...



P15: relapsing erosive polyarthritis associated with hidradenitis suppurativa

Thu, 25 Feb 2016 00:00:00 +0100

Conclusions In conclusion, we propose that inflammatory spondyloarthropathy may be a complication of HS. (Source: Journal of Investigative Medicine)



The extended structure of the periplasmic region of CdsD, a structural protein of the Type III Secretion System of Chlamydia trachomatis

Wed, 24 Feb 2016 15:34:21 +0100

This article is protected by copyright. All rights reserved. (Source: Protein Science)



'Vaginal seeding' may put newborns at risk of infection

Wed, 24 Feb 2016 14:00:00 +0100

"'Vaginal seeding' of babies born by C-section could pose infection risk," The Guardian reports.  The practice of exposing babies born by caesarean section to their mother's vaginal fluid in an effort to boost their immunity may actually lead to an infection, experts say. Vaginal seeding involves rubbing vaginal fluid on the baby with the intention of exposing it to the "healthy" bacteria it would be exposed to in a vaginal birth. However, there is no evidence the practice is effective, and it runs the risk of babies developing serious infections from potentially harmful bacteria or viruses mothers may be unaware they are carrying. The most effective and safe way you can improve your baby's immunity is through breastfeeding. Where did the story come from? Doct...



Acceptability of a Home-based Chlamydia Retesting StrategyAcceptability of a Home-based Chlamydia Retesting Strategy

Wed, 24 Feb 2016 06:19:58 +0100

Chlamydia retesting three months after treatment is recommended, but adherence to this is low. Could a home-based test improve compliance and reduce costs? BMC Public Health (Source: Medscape Pathology Headlines)

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A Coming of Age Story: Chlamydia in the Post-Genetic Era [Minireviews]

Wed, 24 Feb 2016 00:00:00 +0100

Chlamydia spp. are ubiquitous, obligate, intracellular Gram-negative bacterial pathogens that undergo a unique biphasic developmental cycle transitioning between the infectious, extracellular elementary body and the replicative, intracellular reticulate body. The primary Chlamydia species associated with human disease are C. trachomatis, which is the leading cause of both reportable bacterial sexually transmitted infections and preventable blindness, and C. pneumoniae, which infects the respiratory tract and is associated with cardiovascular disease. Collectively, these pathogens are a significant source of morbidity and pose a substantial financial burden on the global economy. Past efforts to elucidate virulence mechanisms of these unique and important pathogens were largely hindered by ...



Post-vaccination MDEM associated with MOG antibody in a subclinical Chlamydia infected boy

Wed, 24 Feb 2016 00:00:00 +0100

In this report, we describe the case of a 6-year-old Japanese boy who had multiphasic disseminated encephalomyelitis (MDEM), and was positive for both anti-myelin oligodendrocyte glycoprotein (MOG) antibodies and Chlamydophila pneumoniae antibodies. After vaccinations that were the second one for measles and rubella, and the booster immunization for Japanese encephalitis, the patient presented with fever, headache, vomiting, and a change in personality. (Source: Brain and Development)



Sexually Transmitted Infections: Experience in a Multidisciplinary Clinic in a Tertiary Hospital (2010-2013)

Tue, 23 Feb 2016 00:00:00 +0100

Conclusion This study confirms the increase in the incidence of STIs in recent years and the epidemiological characteristics of the HIV/STI epidemic in Spain. (Source: Actas Dermo-Sifiliograficas)



Thiazolino 2-Pyridone Amide Inhibitors of Chlamydia trachomatis Infectivity

Mon, 22 Feb 2016 21:18:44 +0100

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.5b01759 (Source: Journal of Medicinal Chemistry)



The novel chlamydial adhesin CPn0473 mediates the lipid raft‐dependent uptake of Chlamydia pneumoniae

Sun, 21 Feb 2016 00:00:00 +0100

Summary Chlamydiae are Gram‐negative, obligate intracellular pathogens that pose a serious threat to public health worldwide. Chlamydial surface molecules are essential for host cell invasion. The first interaction with the host cell is thereby accomplished by the Outer membrane complex protein B (OmcB) binding to heparan sulfate moieties on the host cell surface, followed by the interaction of the chlamydial polymorphic membrane proteins (Pmps) with host cell receptors. Specifically, the interaction of the Pmp21 adhesin and invasin with its human interaction partner, the epidermal growth factor receptor, results in receptor activation, down‐stream signalling and finally internalization of the bacteria. Blocking both, the OmcB and Pmp21 adhesion pathways, did not completely abolish inf...

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Ocular manifestations of infectious skin diseases

Sat, 20 Feb 2016 21:35:22 +0100

Ocular complications of infectious skin diseases are a common occurrence. Managing the inflamed or infected eye in the emergency setting presents a diagnostic and therapeutic challenge to the emergency physician. Infectious agents may affect any part of the eye. Ocular findings may be the first sign of many infectious diseases, such as, for example, gonorrhea or chlamydia infection. Understanding the various forms of ocular involvement in these conditions is important, because untreated ophthalmic involvement can lead to severe vision loss. (Source: Clinics in Dermatology)



No Differences Found in Chlamydia Prevalence Rates Between Males and Females in Chilean Adolescents and Youth

Fri, 19 Feb 2016 14:08:31 +0100

Chlamydia trachomatis (CT) is the most frequently notified STD in adolescents and youth worldwide. However, prevalence rates are currently not available in Chile since CT is not a notifiable disease in our country. Moreover, Chilean CT prevalence studies have involved only females to date. Therefore we aim to evaluate prevalence rates in both sexes. (Source: Journal of Pediatric and Adolescent Gynecology)



Chorioamnionitis in Teenage Births: A Retrospective Cohort Study

Fri, 19 Feb 2016 14:08:31 +0100

Our county is one of three counties in Illinois with the highest rates of teen pregnancies and sexually transmitted diseases (STDs). Prior studies have shown that teenage pregnancy, STD and chorioamnionitis lead to preterm birth. Our objective was to determine the relationship between chorioamnionitis and preterm birth as well as STDs (Gonorrhea, Chlamydia, Trichomonas) in the teenage population. (Source: Journal of Pediatric and Adolescent Gynecology)



Improving Chlamydia Screening Rates at an Urban Primary Care Clinic

Fri, 19 Feb 2016 14:08:30 +0100

Our objective was to increase by 10% routine chlamydia (CT) screening rates of sexually active females aged 15-19 by primary care providers at an urban pediatric and adolescent clinic by May 2015. The CDC, ACOG, and AAP recommend routine annual CT screening for sexually active adolescent females. CT screening programs can lead to up to a 60% reduction in the incidence of PID. A prior study demonstrated that only 2.6% of adolescent patients seen for well visits at all 29 pediatric primary care practices affiliated with our children’s hospital had been screened in the prior year. (Source: Journal of Pediatric and Adolescent Gynecology)



Prevalence of microorganisms co-infections in human papillomaviruses infected women in Northern China

Thu, 18 Feb 2016 00:34:29 +0100

Conclusion The study demonstrated a significant association between HPV and HBV, bacterial vaginosis, C. trachomatis and U. urealyticum. The study results suggest that it may be important to screen for the simultaneous presence of different microorganism co-infections with HPV that may have synergistic pathological effects. (Source: Archives of Gynecology and Obstetrics)

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Highlights from this issue

Thu, 18 Feb 2016 00:00:00 +0100

Syphilis, has always been known the "protean" disease, capable of manifesting in many forms and deceiving physicians as to its true nature. It confused Hunter, whose inoculation experiments1 were the forerunner of the Tuskegee and Guatemala experiments2—it is disputed whether he experimented on himself, but not that he inoculated others in support of a unitary theory of gonorrhoea and syphilis. The huge impact of syphilis on pre-penicillin public health together with its place at the centre of moral debate, and the difficulty of diagnosis made it central to paradigm shifts in the philosophy of science as described in Fleck's seminal work "The Genesis and Development of a Scientific Fact",3 first published in German in 1935. Many developed countries have seen a huge resurgence of syph...



Addressing structural challenges for the sexual health and well-being of Indigenous women in Australia

Thu, 18 Feb 2016 00:00:00 +0100

According to the most recent national data in Australia, chlamydia and gonorrhoea were 3 and 18 times more likely to be diagnosed in Aboriginal populations, respectively, compared with the non-Indigenous population, with 16–19 years old Indigenous Australians carrying the greatest burden of these infections.1 Reports confirm that almost half this age group living in remote communities has one or more of gonorrhoea, chlamydia and trichomonas infections.2 In addition, significant increases in the prevalence of chronic hepatitis B and higher rates of hepatitis C acquired through burgeoning injecting drug use, combined with high rates of chronic disease, means there is a significant burden of disease among Aboriginal and Torres Strait Islander people that costs individuals, communit...



Self-perceived risk and prevalent chlamydia infection among adolescents in Norway: a population-based cross-sectional study

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions These sexually experienced adolescents acknowledged their chlamydia infection risk, but wrong beliefs were incorporated in their assessments, and more than half had incorrect risk perception. We suggest that sexually transmitted infection prevention programmes should be directed at closing the gap between perceived and actual risk and focus on how context may bias personal judgement. (Source: Sexually Transmitted Infections)



Meeting sexual partners online: associated sexual behaviour and prevalent chlamydia infection among adolescents in Norway: a cross-sectional study

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions This population-based study suggests that internet-partners are common among adolescents in Norway, and the reason for meeting them was more strongly associated with additionally reporting sexual risk behaviours and prevalent chlamydia infection than the internet itself as a meeting venue. (Source: Sexually Transmitted Infections)



What is the most appropriate treatment for rectal Chlamydia trachomatis infection?

Thu, 18 Feb 2016 00:00:00 +0100

The updated UK national guideline for the management of Chlamydia trachomatis (CT) is due to be published, and will for the first time include specific recommendations for the treatment of rectal infection. Azithromycin and doxycycline were thought to be equally efficacious for the treatment of genital CT, but a recent meta-analysis found a benefit of up to 7% in favour of doxycycline.1 We previously published the findings of a prospective observational study that found a higher treatment failure rate with azithromycin compared with doxycycline therapy for rectal CT infection (26.2% vs 0%, p=0.0025).2 We retrospectively reviewed our data on all patients attending a large, inner city sexual health clinic who were diagnosed with rectal CT from 1 October 2010 to 1 June 2014 following the chan...

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Retesting young STI clinic visitors with urogenital Chlamydia trachomatis infection in the Netherlands; response to a text message reminder and reinfection rates: a prospective study with historical controls

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions A text message reminder appeared to have a clear, positive impact on the resulting retest rate. These results also indicate that retesting is necessary to identify chlamydia reinfections. (Source: Sexually Transmitted Infections)



An estimate of the proportion of symptomatic gonococcal, chlamydial and non-gonococcal non-chlamydial urethritis attributable to oral sex among men who have sex with men: a case-control study

Thu, 18 Feb 2016 00:00:00 +0100

Conclusions The pharynx is an important source of gonococcal transmission, and may be important in the transmission of chlamydia and other, unidentified pathogens that cause urethritis. Efforts to increase pharyngeal gonorrhoea screening among MSM could diminish STI transmission. (Source: Sexually Transmitted Infections)



Duration of gonorrhoea and chlamydia infection at the pharynx and rectum among men who have sex with men: a systematic review

Thu, 18 Feb 2016 00:00:00 +0100

Eric P. F. Chow, Shayne Camilleri, Christopher Ward, Sarah Huffam, Marcus Y. Chen, Catriona S. Bradshaw, Christopher K. Fairley The aim of this study is to estimate the duration of both infections at the extragenital sites from published epidemiological cohort studies. English peer-reviewed articles were searched from 1 January 2000 to 12 March 2015 in three electronic databases (MEDLINE, EMBASE and Cochrane Central). The prevalence-to-incidence ratio from each study was calculated to reflect the duration of each infection. There were 2585 records identified, with 1721 abstracts and 52 full-text articles screened, resulting in four studies fulfilling the inclusion criteria. Pharyngeal gonorrhoea (114–138 days) had a shorter duration of infection than rectal gonorrhoea (346 days). ...



What would be missed if we didn't screen men who have sex with men for oral chlamydia trachomatis? A cross-sectional study

Thu, 18 Feb 2016 00:00:00 +0100

This study determined a very low overall test positivity of 0.6%. (Source: Sexual Health)



The TNF-α-308G/A Polymorphism is Not Associated with Ocular Chlamydia trachomatis Infection in Han Chinese Children.

Wed, 17 Feb 2016 23:36:02 +0100

CONCLUSIONS: The TNF-α-308A polymorphism is unlikely to play a major role in the risk for ocular C. Trachomatis in the Chinese population. PMID: 26771145 [PubMed - as supplied by publisher] (Source: Ophthalmic Genetics)

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Role of pathogens in multiple sclerosis.

Wed, 17 Feb 2016 14:23:02 +0100

Authors: Libbey JE, Cusick MF, Fujinami RS Abstract Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease of the central nervous system (CNS). Although the etiology of MS is unknown, genetic and environmental factors play a role. Infectious pathogens are the likely environmental factors involved in the development of MS. Pathogens associated with the development or exacerbation of MS include bacteria, such as Mycoplasma pneumoniae and Chlamydia pneumoniae, the Staphylococcus aureus-produced enterotoxins that function as superantigens, viruses of the herpes virus (Epstein-Barr virus and human herpesvirus 6) and human endogenous retrovirus (HERV) families and the protozoa Acanthamoeba castellanii. Evidence, from studies with humans and animal models, supporting ...



Intra-ChIP: studying gene regulation in an intracellular pathogen.

Wed, 17 Feb 2016 00:00:00 +0100

Authors: Hanson BR, Tan M Abstract Intracellular bacteria that reside within a host cell use a variety of strategies to exploit this unique niche. While these organisms are technically challenging to study in the context of an infected host cell, recent advances have led to an improved understanding of how the intracellular environment impacts bacterial gene expression. We recently demonstrated that chromatin immunoprecipitation (ChIP) can be used to quantify transcription factor binding in the obligate intracellular pathogen Chlamydia trachomatis within infected cells. Furthermore, we showed it was possible to experimentally modulate transcription factor binding while simultaneously measuring changes in transcription. Here we discuss these findings as well as other recent work tha...



Past chlamydia infection 'makes type 2 diabetes 82% more likely'

Tue, 16 Feb 2016 23:30:16 +0100

UCLA scientists found people who have had chlamydia, as well as those previously diagnosed with chicken pox, shingles and intestinal infections are at greater risk of type 2 diabetes. (Source: the Mail online | Health)



Electronic health records can help catch undiagnosed cases of Type 2 diabetes, UCLA researchers find

Tue, 16 Feb 2016 16:26:55 +0100

In 2012, a group of UCLA researchers set out to mine thousands of electronic health records for a more accurate and less expensive way to identify people who have undiagnosed Type 2 diabetes. The researchers got much more than they bargained for. Not only did they develop an algorithm with the potential to vastly increase the number of correct diagnoses of the disease by refining the pool of candidates who are put forward for screening; they also uncovered several previously unknown risk factors for diabetes, including a history of sexual and gender identity disorders, intestinal infections and a category of illnesses that includes such sexually transmitted diseases as chlamydia. The findings appear February 16 in the Journal of Biomedical Informatics. “With widespread implementation, ...



Electronic health records can help catch undiagnosed cases of Type 2 diabetes

Tue, 16 Feb 2016 14:01:10 +0100

By mining electronic health records, big data experts have develop a screening algorithm with the potential to vastly increase the number of correct diagnoses of the disease by refining the pool of candidates who are put forward for screening. They also uncovered several previously unknown risk factors for diabetes, including a history of sexual and gender identity disorders, intestinal infections and a category of illnesses that includes such sexually transmitted diseases as chlamydia. (Source: ScienceDaily Headlines)

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New test detects chlamydia in 30 minutes

Tue, 16 Feb 2016 05:00:00 +0100

(University of Bath) University of Bath spin-out biotechnology company Atlas Genetics has won approval from the EU to sell a device that detects the sexually transmitted disease chlamydia. (Source: EurekAlert! - Biology)



Longitudinal biobanks-based study on the joint effects of infections, nutrition and hormones on risk of prostate cancer.

Mon, 15 Feb 2016 00:00:00 +0100

Conclusion A large follow-up study combining data from several previously investigated exposures to investigate joint effects found no evidence that exposure to two risk factors would increase the risk of prostate cancer from that expected on basis of exposure to one risk factor. If anything, the results were consistent with antagonistic interactions. PMID: 26878091 [PubMed - as supplied by publisher] (Source: Acta Oncologica)



Socio-demographic and structural barriers to being tested for chlamydia in general practice.

Sat, 13 Feb 2016 16:45:01 +0100

CONCLUSION: One in five young people did not submit a specimen for chlamydia testing despite their GP requesting it. This highlights the need for clinics to establish systems which ensure that men and those aged 16-19 years undertake chlamydia tests requested by a GP. PMID: 26866549 [PubMed - in process] (Source: Medical Journal of Australia)



Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections

Sat, 13 Feb 2016 00:00:00 +0100

Abstract Bacterial vaginosis (BV) is a common vaginal disorder in women of reproductive age. Since the initial work of Leopoldo in 1953 and Gardner and Dukes in 1955, researchers have not been able to identify the causative etiologic agent of BV. There is increasing evidence, however, that BV occurs when Lactobacillus spp., the predominant species in healthy vaginal flora, are replaced by anaerobic bacteria, such as Gardenella vaginalis, Mobiluncus curtisii, M. mulieris, other anaerobic bacteria and/or Mycoplasma hominis. Worldwide, it estimated that 20–30 % of women of reproductive age attending sexually transmitted infection (STI) clinics suffer from BV, and that its prevalence can be as high as 50–60 % in high-risk populations (e.g., those who practice commercial sex wor...



Control of Trachoma from Achham District, Nepal: A Cross-Sectional Study from the Nepal National Trachoma Program

Fri, 12 Feb 2016 00:00:00 +0100

Conclusion/Significance This previously highly endemic district in Nepal has little evidence of recent clinical disease, chlamydia trachomatis infection, or serological evidence of trachoma, suggesting that epidemiological control has been achieved. (Source: PLoS Neglected Tropical Diseases)

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History of Assisted Reproductive Technology and Chlamydia Trachomatis Infection in Pregnancy.

Thu, 11 Feb 2016 08:15:03 +0100

CONCLUSIONS: A history of ART seemed to be a negative risk factor for CT infection in pregnant women. PMID: 26858799 [PubMed] (Source: Clin Med Res)



A Comparison of Two Mathematical Modeling Frameworks for Evaluating Sexually Transmitted Infection Epidemiology

Thu, 11 Feb 2016 03:34:10 +0100

Conclusions: The frequency-dependent assumption is problematic when modeling short-term STIs. Frequency-dependent models tend to underestimate the importance of high-risk groups in sustaining STI epidemics, while overestimating the importance of long-term partnerships and low-risk groups. (Source: Sexually Transmitted Diseases)



Racial Differences in Receipt of Chlamydia Testing Among Medicaid-Insured Women in 2013

Thu, 11 Feb 2016 03:34:10 +0100

Conclusions: Higher chlamydia testing rates among black women can be explained in part by higher rates of previous STD diagnoses. Our finding that black women have the highest chlamydia testing rates is encouraging, as improved access to STD prevention services among racial/ethnic minorities can help to reduce racial/ethnic disparities in STDs. However, chlamydia screening remains an underused preventive health service for young women of all racial and ethnic groups. (Source: Sexually Transmitted Diseases)



Measuring Health and Quality of Life for Women Undergoing Testing and Screening for Chlamydia: A Systematic Review

Thu, 11 Feb 2016 03:34:10 +0100

Conclusions: Although researchers have begun to examine the relationships between QoL and sexual health, there are limitations associated with the evidence available. There is, thus, a need for further research exploring sexual health and QoL for patients undergoing testing and screening for curable STIs, with a focus on analyzing the most appropriate methodological approaches in this context. (Source: Sexually Transmitted Diseases)



Characteristics Associated With Urethral and Rectal Gonorrhea and Chlamydia Diagnoses in a US National Sample of Gay and Bisexual Men: Results From the One Thousand Strong Panel

Thu, 11 Feb 2016 03:34:10 +0100

Background: Gay and bisexual men are at elevated risk for Neisseria gonorrhoeae and Chlamydia trachomatis (GC/CT). Rectal GC/CT symptoms may be less obvious than urethral, increasing opportunities for undiagnosed rectal GC/CT. Methods: A US national sample of 1071 gay and bisexual men completed urethral and rectal GC/CT testing and an online survey. Results: In total, 6.2% were GC/CT positive (5.3% rectal, 1.7% urethral). We calculated adjusted (for education, race, age, relationship status, having health insurance, and income) odds ratios for factors associated with rectal and urethral GC/CT diagnoses. Age was inversely associated with urethral and rectal GC/CT. Compared with white men, Latinos had significantly greater odds of rectal GC/CT. Among men who reported anal sex, those report...

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Prevalence and Correlates of a Diagnosis of Sexually Transmitted Infection Among Young Aboriginal and Torres Strait Islander People: A National Survey

Thu, 11 Feb 2016 03:34:10 +0100

This article reports the prevalence of self-reported STI diagnoses and their correlates among Aboriginal people aged 16 to 29 years. Methods: Results were analyzed from a survey conducted between 2011 and 2013 at regular community events. Univariate and multivariate logistic regression models were used to identify the correlates of a history of STI diagnosis among participants who reported being sexually active and ever having been tested for STIs. All analyses were stratified by sex. Results: Of the 2877 participants in this study, 2320, comprising 60% females, self-reported ever having had vaginal or anal sex, and a further subset of 1589 (68%) reported ever being tested for any of the following STIs: chlamydia, gonorrhea, syphilis, or trichomonas. Within this latter group, the proport...



A Comparison of Two Mathematical Modeling Frameworks for Evaluating Sexually Transmitted Infection Epidemiology.

Thu, 11 Feb 2016 03:13:02 +0100

CONCLUSIONS: The frequency-dependent assumption is problematic when modeling short-term STIs. Frequency-dependent models tend to underestimate the importance of high-risk groups in sustaining STI epidemics, while overestimating the importance of long-term partnerships and low-risk groups. PMID: 26859800 [PubMed - in process] (Source: Herpes)



Continuing reductions in HPV 16/18 in a population with high coverage of bivalent HPV vaccination in England: an ongoing cross-sectional study

Thu, 11 Feb 2016 00:00:00 +0100

Conclusions These data demonstrate a reduction in the HPV vaccine types in the age group with the highest HPV vaccination coverage. (Source: BMJ Open)



2015 UK national guideline for the management of infection with Chlamydia trachomatis

Thu, 11 Feb 2016 00:00:00 +0100

This guideline offers recommendations on the diagnostic tests, treatment regimens and health promotion principles needed for the effective management of Chlamydia trachomatis genital infection. It covers the management of the initial presentation, as well the prevention of transmission and future infection. The guideline is aimed at individuals aged 16 years and older presenting to healthcare professionals working in departments offering Level 3 care in sexually transmitted infections management within the UK. However, the principles of the recommendations should be adopted across all levels, using local care pathways where appropriate. (Source: International Journal of STD and AIDS)



[Prevalence of infections by Chlamydia trachomatis and Neisseria gonorrhoeae among high school students in the Sabana Central area of Cundinamarca, Colombia].

Tue, 09 Feb 2016 02:05:02 +0100

CONCLUSIONS: The prevalence of C. trachomatis detected in this study was lower than the prevalence reported for similar groups; besides, contrary to the general trends, fewer asymptomatic cases were identified in this study. To prioritize preventive strategies in high-risk populations, an epidemiological surveillance system for C. trachomatis and N. gonorrhoeae should be implemented in Colombia, with screening performed using non-invasive molecular techniques. PMID: 26849693 [PubMed - as supplied by publisher] (Source: Biomedica : Revista del Instituto Nacional de Salud)

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A multi-subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFN-γ+ CMI responses protects against a genital infection in minipigs

Tue, 09 Feb 2016 00:00:00 +0100

A multi-subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFN-γ+ CMI responses protects against a genital infection in minipigs Immunology and Cell Biology 94, 185 (February 2016). doi:10.1038/icb.2015.79 Authors: Sarah Bøje, Anja Weinreich Olsen, Karin Erneholm, Jørgen Steen Agerholm, Gregers Jungersen, Peter Andersen & Frank Follmann (Source: Immunology and Cell Biology)



The contribution of Chlamydia-specific CD8+ T cells to upper genital tract pathology

Tue, 09 Feb 2016 00:00:00 +0100

The contribution of Chlamydia-specific CD8+ T cells to upper genital tract pathology Immunology and Cell Biology 94, 208 (February 2016). doi:10.1038/icb.2015.74 Authors: Kelly R Vlcek, Weidang Li, Srikanth Manam, Brian Zanotti, Bruce J Nicholson, Kyle H Ramsey & Ashlesh K Murthy (Source: Immunology and Cell Biology)



Atlas Genetics Gains CE Approval for First Product

Mon, 08 Feb 2016 13:33:18 +0100

Approval of Chlamydia test for marketing and sale in Europe BATH, England, February 8, 2016 -- (Healthcare Sales & Marketing Network) -- Atlas Genetics Ltd ("Atlas Genetics" or the "Company"), the ultra-rapid Point-Of-Care (POC) mol... Diagnostics, RegulatoryAtlas Genetics, Chlamydia, io CT test (Source: HSMN NewsFeed)



Distribution of Chlamydia abortus in Placentas from Naturally and Experimentally Infected Sheep

Sat, 06 Feb 2016 00:00:00 +0100

Publication date: January 2016 Source:Journal of Comparative Pathology, Volume 154, Issue 1 Author(s): V. Smith, J. Finlayson, M. Livingstone, K. Aitchison, A. Flockhart, N. Wheelhouse, S. Wattegedera, M. Rocchi, G. Entrican, D. Longbottom, F. Chianini (Source: Journal of Comparative Pathology)



Flow cytometry as an improved method for the titration of Chlamydiaceae and other intracellular bacteria

Fri, 05 Feb 2016 00:00:00 +0100

In this study we compared the use of flow cytometry with microscopy and Fluorospot for the titration of C. suis as a representative of other intracellular bacteria. Titer determination via Fluorospot was unreliable, while titration via microscopy led to a linear read‐out range of 16 − 64 dilutions and moderate reproducibility with acceptable standard deviations within and between investigators. In contrast, flow cytometry had a vast linear read‐out range of 1,024 dilutions and the lowest standard deviations given a basic training in these methods. In addition, flow cytometry was faster and material costs were lower compared to microscopy. Flow cytometry offers a fast, cheap, precise, and reproducible alternative for the titration of intracellular bacteria like C. suis. © 2016 In...

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Early Detection of Autism (ASD) by a Non-invasive Quick Measurement of Markedly Reduced Acetylcholine & DHEA and Increased β-Amyloid (1-42), Asbestos (Chrysotile), Titanium Dioxide, Al, Hg & often Coexisting Virus Infections (CMV, HPV 16 and 18), Bacterial Infections etc. in the Brain and Corresponding Safe Individualized Effective Treatment.

Thu, 04 Feb 2016 11:42:01 +0100

Authors: Omura Y, Lu D, Jones MK, Nihrane A, Duvvi H, Shimotsuura Y, Ohki M Abstract A brief historical background on Autism & some of the important symptoms associated with Autism are summarized. Using strong Electro Magnetic Field Resonance Phenomenon between 2 identical molecules with identical weight (which received U.S. Patent) non-invasively & rapidly we can detect various molecules including neurotransmitters, bacteria, virus, fungus, metals & abnormal molecules. Simple non- invasive measurement of various molecules through pupils & head of diagnosed or suspected Autism patients indicated that in Autism patients following changes were often found: 1) Acetylcholine is markedly reduced; 2) Alzheimer's disease markers (i.e. β-Amyloid (1-42), Tau Protein, Apolip...



Survey of partner notification practices for sexually transmissible infections in the United States

Thu, 04 Feb 2016 00:00:00 +0100

Fidel A. Desir, Jessica H. Ladd, Charlotte A. Gaydos Partner notification services for chlamydia, gonorrhea, HIV, and syphilis are widely available throughout a convenience sample of testing sites in the United States. Anonymous service availability is relatively low compared to non-anonymous services. (Source: Sexual Health)



Confirmed inguinal lymphogranuloma venereum genovar L2c in a man who had sex with men, Slovenia, 2015

Thu, 04 Feb 2016 00:00:00 +0100

A laboratory-confirmed lymphogranuloma venereum (LGV) case in Slovenia was reported in 2015, in a human immunodeficiency virus (HIV)-negative man presenting with inguinal lymphadenopathy. He reported unprotected insertive anal intercourse with two male partners in Croatia. Variant L2c of Chlamydia trachomatis was detected in clinical samples. Although the patient was eventually cured, the recommended treatment regimen with doxycycline had to be prolonged. (Source: Eurosurveillance)



Home Screening for Bacterial Vaginosis to Prevent Sexually Transmitted Diseases

Thu, 04 Feb 2016 00:00:00 +0100

Conclusions. Young women were very amenable to home screening for BV, gonorrhea, and chlamydia. Treatment of asymptomatic BV with 1 week of oral metronidazole did not decrease the incidence of gonorrhea and/or chlamydia. Clinical Trials Registration. NCT00667368. (Source: Clinical Infectious Diseases)



Young male sex workers are at high risk for sexually transmitted infections, a cross-sectional study from Dutch STI clinics, the Netherlands, 2006–2012

Thu, 04 Feb 2016 00:00:00 +0100

Male sex workers (MSW) are particularly exposed to sexually transmitted infections (STI) including HIV. In the Netherlands, data about STI among MSW are scarce. We estimated chlamydia, gonorrhoea, syphilis and... (Source: BMC Infectious Diseases)

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Confirmed inguinal lymphogranuloma venereum genovar L2c in a man who had sex with men, Slovenia, 2015.

Thu, 04 Feb 2016 00:00:00 +0100

Authors: Matičič M, Klavs I, Videčnik Zorman J, Vidmar Vovko D, Kogoj R, Keše D Abstract A laboratory-confirmed lymphogranuloma venereum (LGV) case in Slovenia was reported in 2015, in a human immunodeficiency virus (HIV)-negative man presenting with inguinal lymphadenopathy. He reported unprotected insertive anal intercourse with two male partners in Croatia. Variant L2c of Chlamydia trachomatis was detected in clinical samples. Although the patient was eventually cured, the recommended treatment regimen with doxycycline had to be prolonged. PMID: 26889644 [PubMed - as supplied by publisher] (Source: Euro Surveill)



Correlates of African American female adolescent offenders 3, 4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") use and sexually transmitted infection morbidity.

Wed, 03 Feb 2016 21:52:02 +0100

Correlates of African American female adolescent offenders 3, 4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") use and sexually transmitted infection morbidity. J Hum Behav Soc Environ. 2016;26(2):194-201 Authors: Stephens T, Holliday RC, Hopkins S, Rose S, Braithwaite R, Smith S Abstract The current study was designed to determine the extent to which self-reported ecstasy use in a population of juvenile adolescent detainees in a southern state is associated with high-risk health behaviors pertaining to sexually transmitted infection (STI) symptomology and past history of STI occurrence. Participants were 764 African American females extracted from an overall sample of 2,260 juvenile offenders housed at selected Youth Development Campuses in the state of Georgia. Si...



Involvement of Lysosome Membrane Permeabilization and Reactive Oxygen Species Production in the Necrosis Induced by Chlamydia Muridarum Infection in L929 cells.

Wed, 03 Feb 2016 00:00:00 +0100

Authors: Chen L, Wang C, Li S, Yu X, Liu X, Ren R, Liu W, Zhou X, Zhang X, Zhou X Abstract Chlamydiae, obligate intracellular bacteria, are associated with a variety of human diseases. Chlamydial life cycle undergoes a bipahsic development: replicative reticulate bodies' phase (RBs) and infectious elementary bodies's phase (EBs). In the end of the chlamydial intracellular life cycle, EBs has to be released to the surrounded cells. Therefore, the interactions between chlamydiae and cell death pathways could greatly influence the outcomes of Chlamydia infection. However, the underlying molecular mechanisms remain elusive. Here, we investigated host cell death after Chlamydia infection in vitro, in L929 cells, and showed that Chlamydia infection induces cell necrosis, as detected by t...



Inverse relationship between microRNA-155 and -184 expression with increasing conjunctival inflammation during ocular Chlamydia trachomatis infection

Wed, 03 Feb 2016 00:00:00 +0100

Trachoma, a preventable blinding eye disease, is initiated by ocular infection with Chlamydia trachomatis (Ct). We previously showed that microRNAs (miR) -147b and miR-1285 were up-regulated in inflammatory trach... (Source: BMC Infectious Diseases)



Association of human papillomavirus and Chlamydia trachomatis with intraepithelial alterations in cervix samples.

Tue, 02 Feb 2016 00:00:00 +0100

This study describes the association between cytological changes in cervical epithelium and the detection of the most relevant aetiological agents of sexually transmitted diseases. Samples collected from 169 patients were evaluated by conventional cytology followed by molecular analysis to detect HPV DNA, Chlamydia trachomatis, herpes simplex virus 1 and 2,Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, andTreponema pallidum, besides genotyping for most common high-risk HPV. An association between cytological lesions and different behavioural habits such as smoking and sedentariness was observed. Intraepithelial lesions were also associated with HPV and C. trachomatis detection. An association was also found between both simple and multiple genotype infection and cytol...

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Male non‐gonococcal urethritis: From microbiological etiologies to demographic and clinical features

Mon, 01 Feb 2016 00:00:00 +0100

ConclusionsPredicting causative microorganisms in men with non‐gonococcal urethritis based on demographic and clinical features is difficult. However, the present study provides useful information to better understand the microbiological diversity in non‐gonococcal urethritis, and to manage patients with non‐gonococcal urethritis appropriately. (Source: International Journal of Urology)



Human GBP1 does not localise to pathogen vacuoles but restricts Toxoplasma gondii

Mon, 01 Feb 2016 00:00:00 +0100

This study highlights fundamental differences between human and murine GBPs and underlines the need to study the functions of GBPs at cellular locations away from PVs. This article is protected by copyright. All rights reserved. (Source: Cellular Microbiology)



Chlamydia psittaci: a relevant cause of community-acquired pneumonia in two Dutch hospitals.

Mon, 01 Feb 2016 00:00:00 +0100

CONCLUSION: In this study, C. psittaci as CAP-causing pathogen was much higher than previously reported. To detect psittacosis, PCR was performed on all CAP patients for whom a sputum sample was available. For clinical use, PCR is a fast method and sputum availability allows genotyping; additional serology can optimise epidemiological investigations. PMID: 26951352 [PubMed - in process] (Source: The Netherlands Journal of Medicine)



Lysine acetylation of major Chlamydia trachomatis antigens

Sat, 30 Jan 2016 00:00:00 +0100

Publication date: Available online 28 January 2016 Source:EuPA Open Proteomics Author(s): Jelena Mihailovic, Aleksandra Inic-Kanada, Katarina Smiljanic, Elisabeth Stein, Talin Barisani-Asenbauer, Tanja Cirkovic Velickovic Chlamydia trachomatis (Ct) is a human pathogen causing trachoma and infertility. We investigated acetylation at lysine residues of chlamydial antigenic proteins: major outer membrane protein (MOMP), 60kDa chaperonin (chlamydial HSP60), elongation factor G (EF–G), enolase and the polymorphic membrane proteins PmpB, PmpE and PmpF. 60kDa chaperonin, EF–G, and PmpB showed the highest degree of acetylation. Our data show that important Ct antigens could be post-translationally modified by acetylation of lysine residues at multiple sites. Further studies are needed ...



Well: Are You at Risk for Sexually Transmitted Infections?

Fri, 29 Jan 2016 21:04:48 +0100

A quick sex quiz from researchers at Johns Hopkins School of Medicine will give you a better idea of your chances of contracting a sexually transmitted infection. (Source: NYT)

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Cell-free Expression of MraY Homologues and Mur Enzymes [Enzymology]

Fri, 29 Jan 2016 00:00:00 +0100

We report the efficient production of MraY homologues from various human pathogens by synthetic cell-free expression approaches and their subsequent characterization. MraY homologues originating from Bordetella pertussis, Helicobacter pylori, Chlamydia pneumoniae, Borrelia burgdorferi, and Escherichia coli as well as Bacillus subtilis were co-translationally solubilized using either detergent micelles or preformed nanodiscs assembled with defined membranes. All MraY enzymes originating from Gram-negative bacteria were sensitive to detergents and required nanodiscs containing negatively charged lipids for obtaining a stable and functionally folded conformation. In contrast, the Gram-positive B. subtilis MraY not only tolerates detergent but is also less specific for its lipid environment. T...



Drop in rates of chlamydia testing attributed to less frequent cervical cancer screening

Fri, 29 Jan 2016 00:00:00 +0100

(Source: Journal of Midwifery and Women's Health)



Risk‐based screening for chlamydia and gonorrhea prior to intrauterine device insertion misses few cases

Fri, 29 Jan 2016 00:00:00 +0100

(Source: Journal of Midwifery and Women's Health)

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The acceptability and cost of a home-based chlamydia retesting strategy: findings from the REACT randomised controlled trial

Thu, 28 Jan 2016 00:00:00 +0100

Chlamydia retesting three months after treatment is recommended to detect reinfections, but retesting rates are typically low. The REACT (retest after Chlamydia trachomatis) randomised trial demonstrated that hom... (Source: BMC Public Health)



Clinical Laboratory Assessment of Mycoplasma genitalium Transcription-Mediated Amplification Using Primary Female Urogenital Specimens [Bacteriology]

Thu, 28 Jan 2016 00:00:00 +0100

Following analysis of primary cervix, vagina, and first-void female urine specimens for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis via commercial transcription-mediated amplification (TMA), residual material was subjected to Mycoplasma genitalium research-use-only TMA. Representation within a 2,478-specimen retrospective study set was established by comparison to a 6-month audit of clinical C. trachomatis TMA (12,999 specimens) on the basis of the C. trachomatis detection rate, specimen source distribution, clinic location, and age. M. genitalium was detected in 282 (11.4%) patients. This rate was higher than those seen with T. vaginalis (9.0%; P = 0.005), C. trachomatis (6.2%), and N. gonorrhoeae (1.4%). Positive M. genitalium results were confirmed by repeat ...