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MedWorm: Whooping Cough



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Whooping Cough category.



Last Build Date: Tue, 29 Mar 2016 14:20:06 +0100

 



Pertussis Vax Wanes, Even With TDaP Booster (CME/CE)

Tue, 29 Mar 2016 02:35:02 +0100

(MedPage Today) -- Protecting against Bordetella pertussis infection remains challenging (Source: MedPage Today Infectious Disease)

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Studies underscore limits of Tdap vaccine

Mon, 28 Mar 2016 15:00:00 +0100

Replacing the first dose of acellular pertussis vaccine with its whole-cell predecessor could cut the rate of whooping cough by about 95% – including in neonates at greatest risk of severe outcomes,... (Source: Family Practice News)



Priming With the Whole-Cell Bordetella pertussis Vaccine

Mon, 28 Mar 2016 00:00:00 +0100

This simulation study using a mathematical model of pertussis transmission assesses whether a priming dose of whole-cell pertussis vaccine is cost-effective at reducing pertussis infection in infants. (Source: JAMA Pediatrics)



Andrew Wakefield, Disgraced Anti-Vax Doctor, Returns With A Documentary At Tribeca Film Fest

Fri, 25 Mar 2016 18:04:09 +0100

Andrew Wakefield is back in the news, thanks to a new, controversial documentary set to premiere at the upcoming Tribeca Film Festival in New York. The film, directed by Wakefield himself, claims that the U.S. Centers for Disease Control and Prevention orchestrated a conspiracy to cover up the "true" reason for America's rising autism diagnosis rates: vaccines.  This is a widely and soundly discredited assertion. Studies from the independent, non-profit Institute of Medicine, the World Health Organization and the CDC have all found that there is no link between receiving vaccines and developing autism spectrum disorder. Instead, what these studies demonstrate is that vaccines are overwhelmingly safe, with very rare cases of side effects, and that they protect children f...

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Anti-Vaxxers Are Officially To Blame For The Rise In 2 Preventable Diseases

Wed, 23 Mar 2016 19:48:40 +0100

The recent rise in the U.S. of vaccine-preventable diseases has been largely blamed on those who refuse to vaccinate their children. Previous analyses have linked anti-vaxxers to certain outbreaks -- like last year's Disneyland measles outbreak -- but there was still some controversy over the connection.  Now a new review funded by the National Institutes of Health has found a correlation between vaccine refusal and the rise of measles and whooping cough (also known as pertussis), two common vaccine-preventable conditions.  Researchers at Emory University and Johns Hopkins Bloomberg School of Health reviewed reported case data in conjunction with previously published studies to better understand the relationship between vaccine refusal, delay or exemption and the f...



[Newsdesk] Infectious disease surveillance update

Tue, 22 Mar 2016 08:07:51 +0100

The Hunter region in New South Wales, Australia, has been experiencing an increase in cases of whooping cough (pertussis) due to booster vaccine shortages. So far in 2016 as of March 3, 271 cases have been reported. For the same period in 2015, 112 cases of whooping cough had been reported. Supplies of the vaccine booster required for those having close contact with babies ran out in February, 2016, during what continues to be the worst outbreak of whooping cough in the region in 5 years. (Source: The Lancet Infectious Diseases)



A Novel IgM‐capture ELISA Using Recombinant Vag8 Fusion Protein for the Accurate and Early Diagnosis of Bordetella pertussis Infection

Mon, 21 Mar 2016 00:00:00 +0100

Abstract An enzyme‐linked immunosorbent assay (ELISA) that measures anti‐pertussis toxin (PT) IgG antibody has been used widely for the serodiagnosis of pertussis; however, the IgG‐based ELISA is inadequate for patients during the acute phase of the disease due to the slow response of anti‐PT IgG antibodies. To solve this problem, we developed a novel IgM‐capture ELISA that measures serum anti‐Bordetella pertussis Vag8 IgM levels for the accurate and early diagnosis of pertussis. First, we confirmed that Vag8 was highly expressed in all B. pertussis isolates tested (n = 30), but little or none in other Bordetella species, and that diphtheria‐tetanus‐acellular pertussis (DTaP) vaccines did not induce anti‐Vag8 IgG antibodies in mice, i.e., the antibody level could be u...



Vaccination aversion has fueled measles and whooping cough outbreaks, study finds

Wed, 16 Mar 2016 01:16:00 +0100

A comprehensive new study of measles and pertussis outbreaks in the United States suggests that adults’ reluctance or refusal to vaccinate themselves and their children has played a key role in the resurgence of diseases that had been largely eradicated in this country. In an analysis published... (Source: Los Angeles Times - Science)

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Vaccine Refusal a Driving Force Behind Measles Outbreaks, Study Finds

Wed, 16 Mar 2016 00:00:00 +0100

As trend continues, researcher fears more outbreaks of whooping cough, too (Source: Pulmonary Medicine News - Doctors Lounge)



New Study Shows Just How Dangerous It Is To NOT Vaccinate

Tue, 15 Mar 2016 19:38:09 +0100

Measles -- a disease that was completely eliminated in the United States 15 years ago -- has captured national attention recently, thanks to outbreaks among unvaccinated travelers who have contracted the disease abroad. At the same time, anti-vaccination sentiments have found footing among some parents worried over unfounded safety concerns.  Now, a new study shows just how closely the two phenomena are intertwined. More than half of reported measles cases in recent outbreaks in the U.S. were among unvaccinated individuals -- most of whom were intentionally unvaccinated for philosophical, rather than medical, reasons. In a third of the cases, researchers did not have enough information about the person's vaccination history to tell if they'd been immunized.  A similar patter...



Vaccine Refusal Drives Measles Outbreaks: Study

Tue, 15 Mar 2016 18:21:32 +0100

As trend continues, researcher fears more outbreaks of whooping cough, too (Source: WebMD Health)



Vaccine Refusal a Driving Force Behind Measles Outbreaks, Study Finds

Tue, 15 Mar 2016 16:00:00 +0100

As trend continues, researcher fears more outbreaks of whooping cough, too (Source: U.S. News - Health)



Kenya: Protect Babies From the Whooping Cough

Fri, 11 Mar 2016 07:33:02 +0100

[Nation] Last month, I asked the obstetrician if she could vaccinate my wife against pertussis, or whooping cough. Her answer was: "It is not recommended." (Source: AllAfrica News: Pregnancy and Childbirth)



Effect of different detoxification procedures on the residual pertussis toxin activities in vaccines.

Thu, 10 Mar 2016 00:00:00 +0100

Authors: Yuen CT, Asokanathan C, Cook S, Lin N, Xing D Abstract Pertussis toxin (PTx) is a major virulence factor produced by Bordetella pertussis and its detoxified form is one of the major protective antigens in vaccines against whooping cough. Ideally, PTx in the vaccine should be completely detoxified while still preserving immunogenicity. However, this may not always be the case. Due to multilevel reaction mechanisms of chemical detoxification that act on different molecular sites and with different production processes, it is difficult to define a molecular characteristic of a pertussis toxoid. PTx has two functional distinctive domains: the ADP-ribosyltransferase enzymatic subunit S1 (A-protomer) and the host cell binding carbohydrate-binding subunits S2-5 (B-oligomer); and ...



Ask Well: Ask Well: Booster Shots for Grown-Ups

Tue, 08 Mar 2016 14:11:04 +0100

By your early 20s, there’s a good chance you are due for some booster vaccinations. (Source: NYT)



FDA Researchers Advance Science for Vaccines to Prevent Mumps and Whooping Cough

Tue, 08 Mar 2016 12:21:00 +0100

Reported cases of mumps and pertussis have risen in the United States in recent years even though many people are vaccinated. As part of the FDA's commitment to protect the public health, FDA scientists are working to learn why more cases are occurring, and how vaccines which are already safe and effective can be made even better. Here's what you should know. (Source: FDA Consumer Health Information Updates)



Parental Vaccine Hesitancy in Quebec (Canada)

Mon, 07 Mar 2016 16:00:05 +0100

This study aims to contribute to the ongoing reflections on tools and indicators of vaccine hesitancy by providing results of a survey on knowledge, attitudes and beliefs (KAB) of parents in Quebec (Canada). We have compared KAB of parents according to: 1) self-reported vaccination status of their child and 2) hesitation during the vaccination decision. Methods Data were collected through the 2014 Quebec study on vaccination against seasonal influenza and pneumococcal infections, a biennial repeated cross-sectional study in the province of Quebec, Canada. This paper presents the results pertaining to parents’ KAB about vaccination; the full report can be found elsewhere.15 Data were collected through a computer-assisted telephone interview survey conducted between March 18 and April 2...



Type III secretion system regulation in Bordetella [Microbiology]

Tue, 01 Mar 2016 00:00:00 +0100

The BvgAS phosphorelay regulates ∼10% of the annotated genomes of Bordetella pertussis and Bordetella bronchiseptica and controls their infectious cycles. The hierarchical organization of the regulatory network allows the integration of contextual signals to control all or specific subsets of BvgAS-regulated genes. Here, we characterize a regulatory node involving a... (Source: Proceedings of the National Academy of Sciences)



When Zika Turns Deadlier: How Anti-Vaccination Misinformation Could Exacerbate an International Health Emergency

Mon, 29 Feb 2016 21:47:04 +0100

The world is in a frenzy over the Zika virus. Researchers established a link between its rise in Brazil and cases of congenital microcephaly in babies of infected pregnant women, with infants born with smaller than expected heads and improper brain development. As of November last year, Brazil's northeastern state of Pernambuco recorded 646 babies born with microcephaly. On February 1, the World Health Organization (WHO) declared the virus and its suspected link to birth defects an international public health emergency. Though we don't yet understand the exact relationship between Zika and microcephaly, there is clear cause for concern. But even more troubling is a virus brewing beneath the surface: rumors circulating online that this birth abnormality is actually caused by the Tdap vacci...

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Single motherhood and neonatal and infant mortality in Sierra Leone, Burkina Faso and Burundi

Mon, 29 Feb 2016 00:00:00 +0100

Childhood mortality is a stubborn problem and remains highest in Sub-Saharan Africa (SSA). Existing research on childhood mortality in SSA indicate that most of the childhood deaths are from preventable causes such as diarrhoea, pneumonia, measles, malaria, HIV and underlying malnutrition, acute respiratory infections, whooping cough, tuberculosis, bronchopneumonia, dirty feeding bottles and utensils, inadequate disposal of household refuse and poor storage of drinking water. However, insufficient attention has been given to maternal marital status and childhood mortality relationships. (Source: Public Health)



Bordetella pertussis epidemiology and evolution in the light of pertussis resurgence.

Sat, 27 Feb 2016 00:00:00 +0100

Authors: Sealey KL, Belcher T, Preston A Abstract Whooping cough, or pertussis, is resurgent in many countries world-wide. This is linked to switching from the use of whole cell vaccines to acellular vaccines in developed countries. Current evidence suggests that this has resulted in the earlier waning of vaccine-induced immunity, an increase in asymptomatic infection with concomitant increases in transmission and increased selection pressure for B. pertussis variants that are better able to evade vaccine-mediated immunity than older isolates. This review discusses recent findings in B. pertussis epidemiology and evolution in the light of pertussis resurgence, and highlights the important role for genomics-based studies in monitoring B. pertussis adaptation. PMID: 26932577 [Pub...



Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics.

Fri, 26 Feb 2016 20:48:02 +0100

Authors: Linnes JC, Rodriguez NM, Liu L, Klapperich CM Abstract Devices based on rapid, paper-based, isothermal nucleic acid amplification techniques have recently emerged with the potential to fill a growing need for highly sensitive point-of-care diagnostics throughout the world. As this field develops, such devices will require optimized materials that promote amplification and sample preparation. Herein, we systematically investigated isothermal nucleic acid amplification in materials currently used in rapid diagnostics (cellulose paper, glass fiber, and nitrocellulose) and two additional porous membranes with upstream sample preparation capabilities (polyethersulfone and polycarbonate). We compared amplification efficiency from four separate DNA and RNA targets (Bordetella per...



Zambia: Zambia Vaccinates 86 Percent Children

Fri, 26 Feb 2016 10:37:01 +0100

[Times of Zambia] Addis Ababa -Zambia has immunised 86 per cent of children countrywide against three infectious diseases namely, diphtheria, pertussis (whooping cough) and tetanus, also known as DPT3. (Source: AllAfrica News: Pregnancy and Childbirth)



Channel formation by RTX-toxins of pathogenic bacteria: Basis of their biological activity

Thu, 25 Feb 2016 00:00:00 +0100

This article is part of a Special Issue entitled: Pore-Forming Toxins edited by Mauro Dalla Serra and Franco Gambale. (Source: Biochimica et Biophysica Acta (BBA) Biomembranes)

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Comparison of the immunogenicity and safety of pentavalent vaccine Quinvaxem in a compact prefilled auto-disabled (cPAD) injection system versus single-dose vials in healthy infants: a phase 3, open-label, randomized, parallel-group, non-inferiority study

Thu, 25 Feb 2016 00:00:00 +0100

Immunization is a cost-effective and life-saving intervention that prevents an estimated two to three million deaths every year from vaccine-preventable diseases.1,2 The aim of the World Health Organization (WHO) Expanded Programme on Immunization (EPI) is to protect children against life-threatening diseases like tuberculosis, diphtheria, neonatal tetanus, whooping cough, poliomyelitis, and measles, as well as hepatitis B3 and Haemophilus influenzae type b (Hib).4 According to the WHO, approximately 22.6 million children worldwide did not receive the full three doses of diphtheria–tetanus–pertussis (DTP3) vaccine in 2012. (Source: International Journal of Infectious Diseases)



Well: Why Pertussis is Making a Comeback

Mon, 22 Feb 2016 21:39:28 +0100

Cases of whooping cough in the U.S. have spiked in recent years. The newer vaccine is not as effective as the old one, but it has fewer side effects. (Source: NYT)



Mayo Clinic Minute: What About Whooping Cough?

Mon, 22 Feb 2016 00:00:00 +0100

Whooping cough (pertussis) is a highly contagious respiratory tract infection marked by a cough so severe it chokes away the ability to breath. It's especially important for mothers-to-be and parents of young children to be aware of the cough and understand how to prevent it.  In this Mayo Clinic Minute, Jeff Olsen speaks with pediatrician Dr. Bob Jacobson [...] (Source: News from Mayo Clinic)



Changes in Predominance of Pulsed-Field Gel Electrophoresis Profiles of Bordetella pertussis Isolates, United States, 2000-2012.

Thu, 18 Feb 2016 11:04:02 +0100

Authors: Cassiday PK, Skoff TH, Jawahir S, Tondella ML Abstract To clarify the characteristics of circulating Bordetella pertussis isolates, we used pulsed-field gel electrophoresis (PFGE) to analyze 5,262 isolates collected in the United States during 2000-2012. We found 199 PFGE profiles; 5 profiles accounted for 72% of isolates. The most common profile, CDC013, accounted for 35%-46% of isolates tested from 2000-2009; however, the proportion of isolates of this profile rapidly decreased in 2010. Profile CDC237, first seen in 2009, increased rapidly and accounted for 29% of 2012 isolates. No location bias was observed among profiles during 2000-2010, but differences were observed among isolates from different states during 2012. Predominant profiles match those observed in recent ...



Monitoring of an antigen manufacturing process.

Tue, 16 Feb 2016 00:00:00 +0100

Authors: Zavatti V, Budman H, Legge R, Tamer M Abstract Fluorescence spectroscopy in combination with multivariate statistical methods was employed as a tool for monitoring the manufacturing process of pertactin (PRN), one of the virulence factors of Bordetella pertussis utilized in whopping cough vaccines. Fluorophores such as amino acids and co-enzymes were detected throughout the process. The fluorescence data collected at different stages of the fermentation and purification process were treated employing principal component analysis (PCA). Through PCA, it was feasible to identify sources of variability in PRN production. Then, partial least square (PLS) was employed to correlate the fluorescence spectra obtained from pure PRN samples and the final protein content measured by a...



Bordetella holmesii infection: current knowledge and a vision for future research.

Sun, 14 Feb 2016 16:32:09 +0100

Authors: Pittet LF, Posfay-Barbe KM Abstract Bordetella holmesii is a recently recognized Gram-negative bacterium causing both pertussis-like respiratory symptoms and invasive infections, such as bacteremia, pneumonia, meningitis, arthritis, pericarditis and endocarditis. Few data are available on its epidemiological characteristics, mostly related to respiratory infections. However, these are frequently misdiagnosed as a Bordetella pertussis infection as most diagnostic tests routinely used are not species-specific, thus biasing the epidemiological studies of both strains, as well as the efficacy studies on pertussis vaccination. There is no accepted agreement on treatment and it remains unknown if antimicrobial prophylaxis is indicated in certain clinical settings. We review here...



CDC advises pregnant women to get aluminum- and formaldehyde-filled Tdap vaccine despite lack of safety

Wed, 10 Feb 2016 06:00:00 +0100

(NaturalNews) The official vaccination schedule issued by the U.S. Centers for Disease Control and Prevention (CDC) advises all pregnant women to get the Tdap vaccine for tetanus, diphtheria and pertussis (whooping cough), warning them that, if they don't, their children could get... (Source: NaturalNews.com)

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Protection from the TdaP vaccine doesn’t last very long

Tue, 09 Feb 2016 14:13:40 +0100

Follow me at @drClaire When my patients come in for their 11-year check-up, I give them the TdaP vaccine. I explain to them that a big part of the reason we give it is to protect them against pertussis, or whooping cough. I talk about outbreaks that are happening all the time, how it can be especially dangerous for little babies, and how this vaccine can help stop them from catching pertussis and spreading it to others. It turns out that’s only true for about 2 to 3 years after getting the vaccine, according to a study just published in the journal Pediatrics. Before the early 1990s, we used a different kind of pertussis vaccine, a “whole-cell” vaccine. It worked quite well, and rates of pertussis were quite low among vaccinated people. But the vaccine had side effects. Fever, swelli...



Proteome analysis of Bordetella pertussis isolated from human macrophages.

Tue, 09 Feb 2016 00:00:00 +0100

Authors: Lamberti Y, Cafiero JH, Surmann K, Valdez H, Holubova J, Branislav V, Sebo P, Schmidt F, Völker U, Rodriguez ME PMID: 26873878 [PubMed - as supplied by publisher] (Source: Journal of Proteomics)



Whooping cough makes a comeback as vaccine wanes

Mon, 08 Feb 2016 21:10:32 +0100

New study finds booster shot protection wears off in older kids; "Basically, we traded effectiveness for safety" (Source: Health News: CBSNews.com)



Whooping cough protection fades fast after booster shot

Mon, 08 Feb 2016 17:22:01 +0100

Stephen FellerOAKLAND, Calif., Feb. 8 (UPI) -- A vaccine booster shot meant to increase protection against pertussis fades over time, researchers at Kaiser Permanente found in a recent study. (Source: Health News - UPI.com)



Effectiveness of routine Tdap booster wanes in adolescents

Fri, 05 Feb 2016 15:53:28 +0100

A new study found that the Tdap booster vaccine provides moderate protection against whooping cough during the first year after vaccination, but its effectiveness wanes to less than 9 percent after four years among teenagers who have received only a newer form of the whooping cough vaccine (acellular pertussis vaccine) as infants and children. (Source: ScienceDaily Headlines)

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Waning Whooping Cough Immunity Blamed in Outbreaks

Fri, 05 Feb 2016 14:16:33 +0100

Teens have very little protection just a few years after vaccination, study finds (Source: WebMD Health)



Whooping cough protection fades fast after Tdap booster, study finds

Fri, 05 Feb 2016 12:55:44 +0100

A booster vaccine for whooping cough, which many states require for middle school-aged children, does not provide long-lasting protection, a study finds. (Source: CNN.com - Health)



Waning Whooping Cough Immunity Blamed in Outbreaks

Fri, 05 Feb 2016 07:00:00 +0100

Title: Waning Whooping Cough Immunity Blamed in OutbreaksCategory: Health NewsCreated: 2/5/2016 12:00:00 AMLast Editorial Review: 2/5/2016 12:00:00 AM (Source: MedicineNet Kids Health General)



Well: Whooping Cough Booster Shot May Offer Only Short-Term Protection

Fri, 05 Feb 2016 05:04:49 +0100

The rapidly fading effectiveness of the pertussis booster vaccine may help explain recent widespread outbreaks of whooping cough. (Source: NYT)

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Why did so many California kids get whooping cough despite being vaccinated?

Fri, 05 Feb 2016 05:00:00 +0100

When California had its biggest pertussis outbreak in more than half a century in 2010, the kids who fell sick most were 10- and 11-year-olds. That struck public health experts as odd. Children receive five doses of the vaccine that protects against the illness — also known as whooping cough —... (Source: Los Angeles Times - Science)



Waning Whooping Cough Immunity Blamed in Outbreaks

Fri, 05 Feb 2016 00:00:00 +0100

Teens have very little protection just a few years after vaccination, study finds (Source: Pulmonary Medicine News - Doctors Lounge)

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Whooping cough booster vouchers don't boost immunization rates of caregivers

Wed, 03 Feb 2016 05:00:00 +0100

(University of Pennsylvania School of Nursing) A team of researchers evaluated the feasibility and impact of different interventions aimed at increasing the number of Tdap vaccinated caregivers. (Source: EurekAlert! - Infectious and Emerging Diseases)



Latent class analysis of diagnostic tests for adenovirus, Bordetella pertussis and influenza virus infections in German adults with longer lasting coughs

Tue, 02 Feb 2016 21:34:34 +0100

Research Articles C. SOBOTZKI, M. RIFFELMANN, N. KENNERKNECHT, C. HÜLSSE, M. LITTMANN, A. WHITE, R. VON KRIES, C. H. WIRSING VON KÖNIG, Epidemiology & Infection, Volume 144 Issue 04, pp 840-846Abstract (Source: Epidemiology and Infection)



Differences in DNA load according to clinical and epidemiological characteristics of patients with whooping cough

Tue, 02 Feb 2016 00:00:00 +0100

To identify associations between nasopharyngeal Bordetella pertussis DNA load and clinical and epidemiological characteristics and evaluate DNA load prognostic value in pertussis severity. (Source: Journal of Infection)



Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3

Tue, 02 Feb 2016 00:00:00 +0100

Integrins are heterodimeric cell surface adhesion and signaling receptors that are essential for metazoan existence. Some integrins contain an I-domain that is a major ligand binding site. The ligands preferentially engage the active forms of the integrins and trigger signaling cascades that alter numerous cell functions. Here we found that the adenylate cyclase toxin (CyaA), a key virulence factor of the whooping cough agent Bordetella pertussis, preferentially binds an inactive form of the integrin complement receptor 3 (CR3), using a site outside of its I-domain. CyaA binding did not trigger downstream signaling of CR3 in human monocytes and CyaA-catalyzed elevation of cAMP effectively blocked CR3 signaling initiated by a natural ligand. This unprecedented type of integrin-ligand intera...



Differences in Bordetella pertussis DNA load according to clinical and epidemiological characteristics of patients with whooping cough

Tue, 02 Feb 2016 00:00:00 +0100

To identify associations between nasopharyngeal Bordetella pertussis DNA load and clinical and epidemiological characteristics and evaluate DNA load prognostic value in pertussis severity. (Source: Journal of Infection)

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Cell-free Expression of MraY Homologues and Mur Enzymes [Enzymology]

Fri, 29 Jan 2016 00:00:00 +0100

We report the efficient production of MraY homologues from various human pathogens by synthetic cell-free expression approaches and their subsequent characterization. MraY homologues originating from Bordetella pertussis, Helicobacter pylori, Chlamydia pneumoniae, Borrelia burgdorferi, and Escherichia coli as well as Bacillus subtilis were co-translationally solubilized using either detergent micelles or preformed nanodiscs assembled with defined membranes. All MraY enzymes originating from Gram-negative bacteria were sensitive to detergents and required nanodiscs containing negatively charged lipids for obtaining a stable and functionally folded conformation. In contrast, the Gram-positive B. subtilis MraY not only tolerates detergent but is also less specific for its lipid environment. T...



CDC channels Natural News, now says whooping cough vaccine doesn't work... but recommends more vaccines anyway

Thu, 28 Jan 2016 06:00:00 +0100

(NaturalNews) It seems that the CDC's only mission is to acquire immunity against its own errors. Even though the Centers for Disease Control and Prevention is known to promote vaccines that incur over 20 possible side effects, including deafness, coma and permanent brain damage,... (Source: NaturalNews.com)



Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin.

Wed, 27 Jan 2016 16:34:03 +0100

Authors: Williams MM, Sen K, Weigand MR, Skoff TH, Cunningham VA, Halse TA, Tondella ML, CDC Pertussis Working Group Abstract A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an unvaccinated infant in New York State in 2013. Comparison with a French strain that was pertussis toxin-deficient, pertactin wild-type showed that the strains carry the same 28-kb deletion in similar genomes. PMID: 26812174 [PubMed - as supplied by publisher] (Source: Emerging Infectious Diseases)



Genomic dissection of Australian isolates from the 2008-2012 epidemic

Wed, 27 Jan 2016 00:00:00 +0100

Despite high pertussis vaccination coverage, Australia experienced a prolonged epidemic in 2008-2012. The predominant Bordetella pertussis genotype harboured pertussis toxin promoter allele, ptxP3, and pertactin gene allele, prn2. The emergence and expansion of non-expressing prn isolates (Prn negative), was also observed. We aimed to investigate the microevolution and genomic diversity of epidemic B. pertussis isolates. (Source: Journal of Infection)



Genomic dissection of Australian isolates from the 2008–2012 epidemic

Wed, 27 Jan 2016 00:00:00 +0100

Despite high pertussis vaccination coverage, Australia experienced a prolonged epidemic in 2008–2012. The predominant Bordetella pertussis genotype harboured pertussis toxin promoter allele, ptxP3, and pertactin gene allele, prn2. The emergence and expansion of non-expressing prn isolates (Prn negative), were also observed. We aimed to investigate the microevolution and genomic diversity of epidemic B. pertussis isolates. (Source: Journal of Infection)

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Understanding the true burden and infection dynamics of Bordetella pertussis using molecular diagnostics

Wed, 27 Jan 2016 00:00:00 +0100

We read with interest the article by Guiso et al. regarding the continued circulation of Bordetella pertussis despite numerous health interventions.1 Key to controlling the circulation of any pathogen is the ability to provide rapid and reliable standardised diagnostic methods that also allow accurate surveillance of the disease. Clinical diagnosis of pertussis can be made upon presence of a characteristic whoop; however neonates and previously vaccinated adolescents and adults often present atypically without the characteristic paroxysms. (Source: Journal of Infection)



Genomic dissection of Australian Bordetella pertussis isolates from the 2008–2012 epidemic

Wed, 27 Jan 2016 00:00:00 +0100

Despite high pertussis vaccination coverage, Australia experienced a prolonged epidemic in 2008–2012. The predominant Bordetella pertussis genotype harboured pertussis toxin promoter allele, ptxP3, and pertactin gene allele, prn2. The emergence and expansion of prn non-expressing isolates (Prn negative), were also observed. We aimed to investigate the microevolution and genomic diversity of epidemic B. pertussis isolates. (Source: Journal of Infection)



Changes in Predominance of Pulsed-Field Gel Electrophoresis Profiles of Bordetella pertussis Isolates, United States, 2000–2012

Mon, 25 Jan 2016 05:00:00 +0100

P. K. Cassiday et al. (Source: Emerging Infectious Diseases Journal)



Whooping cough in a renal transplant recipient

Mon, 25 Jan 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Transplant Infectious Disease)



Researchers study motivations of parents who refuse to vaccinate children

Sun, 24 Jan 2016 03:26:57 +0100

Pilot study investigates why parents choose not to vaccinate and why many do not to disclose that their children aren’t immunised, potentially putting others at riskThe health of pregnant women and their babies is at risk from parents who refuse to disclose that their children have not been vaccinated, according to researchers in Western Australia who have launched a pilot study to investigate the motivations of anti-vaccinators.Dr Bronwyn Harman, a families researcher with Edith Cowan University’s school of psychology and social science in Western Australia, said unvaccinated children could be carrying diseases such as rubella and whooping cough that are dangerous to pregnant women and newborns. Continue reading... (Source: Guardian Unlimited Science)

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Florida Pertussis Outbreak Shows Vaccine Works -- But Not Well Enough

Tue, 19 Jan 2016 11:30:00 +0100

A pertussis outbreak sickening one in five mostly vaccinated students at a Florida daycare in 2013 reiterates two important messages when it comes to the whooping cough vaccine, say experts: getting vaccinated on time is more important than ever, and we need a better vaccine as soon as possible. The outbreak, described in a study in the CDC’s Emerging Infectious Disease journal, reports the first known outbreak of pertussis in a mostly vaccinated group of children in the U.S. (Source: Forbes.com Healthcare News)



Whooping Cough Outbreak: How Effective Is the Vaccine?

Thu, 14 Jan 2016 15:35:00 +0100

Widespread pertussis vaccine use at a Florida preschool failed to keep the disease away from about three dozen students, staff and family members -- Read more on ScientificAmerican.com (Source: Scientific American)



Reciprocal interference of maternal and infant immunization in protection against pertussis.

Thu, 14 Jan 2016 00:00:00 +0100

CONCLUSION: It may be important to determine the functionality of antibodies to evaluate potential interference of maternal and infant vaccination in protection against pertussis. PMID: 26776471 [PubMed - as supplied by publisher] (Source: Vaccine)



Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin

Wed, 13 Jan 2016 05:00:00 +0100

M. M. Williams et al. (Source: Emerging Infectious Diseases Journal)



Absence of Bordetella pertussis Among Infants Hospitalized for Bronchiolitis in Finland, 2008–2010

Tue, 12 Jan 2016 20:15:40 +0100

In 169 Finnish infants hospitalized for bronchiolitis at age (Source: The Pediatric Infectious Disease Journal)

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Trends and socioeconomic disparities in preadolescent's health in the UK: evidence from two birth cohorts 32 years apart

Mon, 11 Jan 2016 00:00:00 +0100

Conclusions There have been reductions in infectious diseases and tobacco exposure among British preadolescents, but overweight and allergic conditions have risen dramatically. Children from deprived families have benefitted least from improvements in health status, and have experienced the largest increases in health risks. (Source: Journal of Epidemiology and Community Health)



Validation of a loop-mediated isothermal amplification assay for rapid diagnosis of pertussis infection in nasopharyngeal samples.

Wed, 23 Dec 2015 11:54:04 +0100

CONCLUSION: The new test was shown to be 2.5-fold faster than real-time PCR while maintaining similar levels of analytical and clinical performance. Therefore it could become a useful diagnostic tool for molecular point-of-care testing. PMID: 26565672 [PubMed - as supplied by publisher] (Source: Expert Review of Molecular Diagnostics)



Postepy Hig Med Dosw 2015; 69:1013-1030 "Bordetella pertussis lipooligosaccharide-derived neoglycoconjugates – new components of pertussis vaccine"

Tue, 22 Dec 2015 00:23:54 +0100

Pertussis is a contagious respiratory tract disease caused by the Gram-negative bacterium Bordetella pertussis. Despite widespread vaccination, in recent years the pertussis incidence has increased. The whole-cell pertussis vaccine has been very effective but reactogenic. Therefore the improved vaccines contain only a few isolated and inactivated antigens of B. pertussis. However, a waning of the acellular vaccine-induced immunity indicates that these vaccines lack some important protective B. pertussis antigens. The vaccine containing an inactivated pertussis toxin induces the production of toxin-neutralizing antibodies, but it does not lead to destruction of bacteria. Since many virulence factors are involved in the pathogenesis of pertussis, beside the toxin-neutralizing activity, the d...



Expert alert: Pertussis — What to look for and when to be treated

Mon, 21 Dec 2015 00:00:00 +0100

ROCHESTER, Minn. — Pertussis, also known as whooping cough, has been found in the Rochester community. Many Rochester schools, sports teams and day care providers are affected by this outbreak. Pertussis is a contagious bacterial illness spread when a person coughs or sneezes. Those at greatest risk of medical complications include infants less than 1 [...] (Source: Mayo Clinic Rochester News)



The potential role of subclinical Bordetella Pertussis colonization in the etiology of multiple sclerosis.

Fri, 18 Dec 2015 00:00:00 +0100

Authors: Rubin K, Glazer S Abstract It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, when co-administered with neural antigens, induces neuropathology in experimental autoimmune encephalomyelitis, the principle animal model of multiple sclerosis. Building on these observations with supporting epidemiologic and biologic evidence, we propose that, contrary to conventional wisdom that subclinical pertussis infections are innocuous to hosts, B. pertussis colonization is an important cause of multiple sclerosis. PMID: 26724970 [PubMed - as supplied by publisher] (Source: Immunobiology)

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Multiplex real-time PCR assay for detection and differentiation of Bordetella pertussis and Bordetella parapertussis.

Sat, 12 Dec 2015 04:15:31 +0100

CONCLUSIONS: Developed multiplex real-time PCR offers a fast tool with high sensitivity and specificity for the diagnosis of B. pertussis and B. parapertussis infections which is suitable for implementation in a routine laboratory diagnostics. PMID: 25870746 [PubMed] (Source: Iranian Journal of Microbiology)



Why ‘Tolerating’ Anti-Vaxxers Is a Losing Strategy

Thu, 10 Dec 2015 18:50:18 +0100

Now and then, in just the right situations, there’s a lot to be said for intolerance—especially when it comes to the safety of kids. We don’t tolerate bullying in schools on the false belief that a few scuffles can build character. We don’t tolerate smoking on playgrounds because parents should have the right to determine the tobacco habits of their second-graders. And we shouldn’t—but too often still do—tolerate parents who deny established science and refuse to vaccinate their school-age children, potentially endangering every other child in the school and the community beyond as well. That’s a lesson the families at Brunswick North West Primary School in Melbourne, Australia are learning in the worst way possible after as many as 80 of 320...



The relationship between genotype and clinical severity in Australian children with pertussis

Mon, 07 Dec 2015 00:00:00 +0100

Changes in circulating Bordetella pertussis genotypes, including a novel pertussis toxin promoter ptxP3 allele and absence of pertactin (Prn) antigen, have been reported from several countries but limited data on relative severity are available. We compared markers of disease severity in children with B. pertussis infection due to strains of differing genotype. (Source: Journal of Infection)



Scientists develop potential treatment for whooping cough

Thu, 03 Dec 2015 16:37:03 +0100

Stephen FellerAUSTIN, Texas, Dec. 3 (UPI) -- Scientists at the University of Texas have developed two antibodies that could reduce the occurrence and threat of whooping cough in unvaccinated children. (Source: Health News - UPI.com)



Engineers develop potential treatment for whooping cough

Thu, 03 Dec 2015 13:19:18 +0100

Engineers are making progress on a potential Whooping Cough treatment for vulnerable infants. In preclinical testing conducted on animals, the team demonstrated that their antibodies work as a prophylaxis to provide short-term immunity and as a treatment to accelerate recovery. (Source: ScienceDaily Headlines)

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[Research Articles] A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough

Wed, 02 Dec 2015 00:00:00 +0100

Despite widespread vaccination, pertussis rates are rising in industrialized countries and remain high worldwide. With no specific therapeutics to treat disease, pertussis continues to cause considerable infant morbidity and mortality. The pertussis toxin is a major contributor to disease, responsible for local and systemic effects including leukocytosis and immunosuppression. We humanized two murine monoclonal antibodies that neutralize pertussis toxin and expressed them as human immunoglobulin G1 molecules with no loss of affinity or in vitro neutralization activity. When administered prophylactically to mice as a binary cocktail, antibody treatment completely mitigated the Bordetella pertussis–induced rise in white blood cell counts and decreased bacterial colonization. When admin...



Bordetella pertussis diagnosis in children under five years of age in the Regional Hospital of Cajamarca, Northern Peru

Mon, 30 Nov 2015 21:57:27 +0100

Conclusions: B. pertussis is responsible for an important proportion of whooping cough in hospitalized children in Cajamarca. Epidemiologic surveillance programs for B. pertussis are essential in Peru, especially in children who could most benefit from the vaccine. (Source: The Journal of Infection in Developing Countries)



The estimated incidence of pertussis in people aged 50 years old in the United States, 2006–2010

Thu, 19 Nov 2015 00:00:00 +0100

Conclusions: These findings indicate that the B. pertussis disease incidence in adults aged ≥50 years is significantly higher than generally estimated. Additional research regarding pertussis reporting and diagnosis in the adult populations is needed to validate these findings. (Source: BMC Infectious Diseases)



Baby's mom posts whooping cough Facebook plea

Wed, 18 Nov 2015 01:23:32 +0100

"For those of you sitting on the fence on whether to vaccinate ... maybe this video will convince you" (Source: Health News: CBSNews.com)

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Well: Whooping Cough in Infants Tied to Epilepsy Risk

Tue, 17 Nov 2015 21:01:18 +0100

Whooping cough is associated with an increased risk for childhood epilepsy, a new study has found. The findings underscore the importance of pertussis vaccination in infants. (Source: NYT)



Heartbreaking Video Of Baby With Whooping Cough Has Strong Message About Vaccinations

Tue, 17 Nov 2015 15:44:57 +0100

An Australian mom has issued a powerful statement about vaccinations with a heartbreaking video of her baby. Mom Rebecca Harreman posted a video on Facebook that shows her 4-month-old son Austin suffering from pertussis, aka whooping cough.  (function(d, s, id) { var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk#xfbml=1&version=v2.3"; fjs.parentNode.insertBefore(js, fjs);}(document, 'script', 'facebook-jssdk'));Okay so I know I said I'd let the hate go. But I'm tired. Damn tired. I've been on duty for over 3 weeks having to wake...Posted by Rebecca Harreman on Friday, November 13, 2015 "I've been on duty for over three weeks having to wake every single tim...



[Correspondence] Mission Indradhanush and the counterfeit drug trade in India

Mon, 16 Nov 2015 05:14:21 +0100

In Lancet Infectious Diseases, Sanjeet Bagcchi's report on Mission Indradhanush summarises India's initiative to provide children protection against diphtheria, whooping cough, tetanus, poliomyelitis, tuberculosis, measles, and hepatitis B.1 However, one of the key questions that hasn't been addressed either in the report or in the published views of India's health minister and health officials2 is what measures are being undertaken by the Indian Health Ministry to guarantee the availability of genuine vaccines at centres associated with Mission Indradhanush? (Source: The Lancet Infectious Diseases)

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Comparison of Three Whole-cell Pertussis Vaccines in the Baboon Model of Pertussis.

Wed, 11 Nov 2015 00:00:00 +0100

Authors: Warfel JM, Zimmerman LI, Merkel TJ Abstract Pertussis is a highly contagious respiratory illness caused by the bacterial pathogen Bordetella pertussis. Pertussis rates in the US have escalated since the 1990s and reached a 50-year high of 48,000 cases in 2012. While this pertussis resurgence is not completely understood, we previously showed that the current acellular pertussis vaccines do not prevent colonization or transmission following challenge. In contrast, a whole-cell pertussis vaccine accelerated the rate of clearance compared to unvaccinated and acellular vaccinated animals. In order to understand if these results are generalizable, we used our baboon model to compare immunity from whole-cell vaccines from three different manufacturers that are approved outside t...



Interspecies Variations in Bordetella Catecholamine Receptor Gene Regulation and Function [Molecular Pathogenesis]

Tue, 10 Nov 2015 00:00:00 +0100

In this study, the bfrD and bfrE genes of B. pertussis were shown to be functional in B. bronchiseptica, but neither B. bronchiseptica bfrD nor bfrE imparted catecholamine utilization to B. pertussis. Gene fusion analyses found that expression of B. bronchiseptica bfrA was increased during iron starvation, as is common for iron receptor genes, but that expression of the bfrD and bfrE genes of both species was decreased during iron limitation. As shown previously for B. pertussis, bfrD expression in B. bronchiseptica was also dependent on the BvgAS virulence regulatory system; however, in contrast to the case in B. pertussis, the known modulators nicotinic acid and sulfate, which silence Bvg-activated genes, did not silence expression of bfrD in B. bronchiseptica. Further studies using a B....



Pertussis vaccines: WHO position paper, August 2015-Recommendations.

Mon, 09 Nov 2015 00:00:00 +0100

This article presents the World Health Organization's (WHO) recommendations for the use of vaccines against Bordetella pertussis from the WHO position paper on Pertussis vaccines: WHO position paper-August 2015, recently published in the Weekly Epidemiological Record (Pertussis vaccines: WHO position paper, August 2015. Wkly Epidemiol Rec 2015;90(35):433-60). This position paper summarizes the most recent developments in the field of pertussis disease and its prevention by vaccination. It includes the WHO position on the choice of Pertussis vaccine as well as on the use of additional strategies, particularly vaccination during pregnancy, for prevention of early infant mortality. This document replaces the first WHO position paper on vaccines against disease caused by Pertussis published in...



Protecting Newborns Against Pertussis: Treatment and Prevention Strategies

Thu, 05 Nov 2015 00:00:00 +0100

Abstract Pertussis is a potentially severe respiratory disease, which affects all age groups from young infants to older adults and is responsible for an estimated 195,000 deaths occurred globally in 2008. Active research is ongoing to better understand the pathogenesis, immunology, and diagnosis of pertussis. For diagnosis, molecular assays (e.g., polymerase chain reaction) for detection of Bordetella pertussis have become more widely available and support improved outbreak detection. In children, pertussis vaccines have been incorporated into routine immunization schedules and deployed for pertussis outbreak control. Lower levels of vaccine coverage are now being observed in communities where vaccine hesitancy is rising. Additionally, recognition that newborn babies are at risk ...

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Protecting Newborns Against Pertussis: Treatment and Prevention Strategies.

Thu, 05 Nov 2015 00:00:00 +0100

Authors: Salim AM, Liang Y, Kilgore PE Abstract Pertussis is a potentially severe respiratory disease, which affects all age groups from young infants to older adults and is responsible for an estimated 195,000 deaths occurred globally in 2008. Active research is ongoing to better understand the pathogenesis, immunology, and diagnosis of pertussis. For diagnosis, molecular assays (e.g., polymerase chain reaction) for detection of Bordetella pertussis have become more widely available and support improved outbreak detection. In children, pertussis vaccines have been incorporated into routine immunization schedules and deployed for pertussis outbreak control. Lower levels of vaccine coverage are now being observed in communities where vaccine hesitancy is rising. Additionally, recogn...



PHA: Remind pregnant women to get whooping cough vaccine

Wed, 04 Nov 2015 16:18:31 +0100

Nurses and health visitors should encourage women who are 28 weeks pregnant or more to get a whooping cough vaccine, the Public Health Agency (PHA) has advised Hide related content:  Show related content read more (Source: Nursing in Practice)



Childhood Whooping Cough Tied to Small Rise in Epilepsy Risk

Wed, 04 Nov 2015 00:00:00 +0100

But chances of any one child getting the seizure illness remain low, one expert says (Source: Pulmonary Medicine News - Doctors Lounge)



Kids' Whooping Cough and Risk of Epilepsy

Tue, 03 Nov 2015 22:15:50 +0100

But chances of any one child getting the seizure illness remain low, one expert says (Source: WebMD Health)



Childhood Whooping Cough Tied to Small Rise in Epilepsy Risk

Tue, 03 Nov 2015 21:00:00 +0100

But chances of any one child getting the seizure illness remain low, one expert says Source: HealthDay Related MedlinePlus Pages: Epilepsy, Whooping Cough (Source: MedlinePlus Health News)

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Infant whooping cough infection tied to later epilepsy risk

Tue, 03 Nov 2015 18:57:39 +0100

(Reuters Health) – Children in Denmark who were diagnosed with pertussis, or “whooping cough,” in early childhood appear to have an increased risk of epilepsy later in childhood, according to a new study. (Source: Reuters: Health)



Surprise Link Between Epilepsy And Whooping Cough: What's The Connection?

Tue, 03 Nov 2015 16:00:00 +0100

One of the more common concerns parents have about vaccines is the fear their child will suffer seizures following vaccination. The fear is grounded in reality: febrile, or fever-induced seizures, can occur after vaccinations. Their risk even increases when the MMR vaccine is delayed, an ironic fact for parents who delay this vaccine out of misguided safety concerns. (Source: Forbes.com Healthcare News)



Detection of using PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian Hospitals.

Fri, 30 Oct 2015 00:00:00 +0100

(Source: International Journal of Infectious Diseases)



Channel formation by RTX-toxins of pathogenic bacteria: Basis of their biological activity.

Fri, 30 Oct 2015 00:00:00 +0100

This article is part of a Special Issue entitled: Pore-Forming Toxins. Guest Editors: Mauro Dalla Serra and Franco Gambale. PMID: 26523409 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)



Detection of using a PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian hospitals

Fri, 30 Oct 2015 00:00:00 +0100

Pertussis is a highly contagious disease of the human respiratory tract caused by the fastidious Gram-negative coccobacillus Bordetella pertussis. B. pertussis is the primary causative agent of ‘whooping cough’. It is transmitted person to person and is characterized by uncontrollable coughing fits, accompanied by inspiratory stridor.1,2 This classical presentation is well-known, but has been observed less often since the implementation of immunization.3 (Source: International Journal of Infectious Diseases)

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Community awareness and predictors of uptake of pertussis booster vaccine in South Australian adults.

Mon, 26 Oct 2015 00:00:00 +0100

CONCLUSIONS: Whilst knowledge regarding transmission and severity of Bordetella pertussis was high, uptake of pertussis vaccination for adults is remarkably low amongst the South Australian community. Improved awareness regarding the availability of a booster pertussis vaccine through Family Physicians and/or provision of funded pertussis vaccination for adults has the potential to improve pertussis vaccine coverage. PMID: 26514422 [PubMed - as supplied by publisher] (Source: Australian Family Physician)



Pertussis Booster In Every Pregnacy Safe For Mother And Child, Study Finds

Tue, 20 Oct 2015 15:01:00 +0100

The resurgence of pertussis, or whooping cough, in recent years has left doctors, researchers and public health officials scrambling to find ways to protect those most likely to die from the disease: infants under 2-3 months old who are too young to be vaccinated. The most promising strategy — giving mom a dose of the pertussis vaccine toward the end of her pregnancy — means getting a booster in every pregnancy. The booster, called Tdap, actually protects against tetanus, diphtheria and pertussis. (Source: Forbes.com Healthcare News)



Pertussis Booster In Every Pregnancy Safe For Mother And Child, Study Finds

Tue, 20 Oct 2015 15:01:00 +0100

The resurgence of pertussis, or whooping cough, in recent years has left doctors, researchers and public health officials scrambling to find ways to protect those most likely to die from the disease: infants under 2-3 months old who are too young to be vaccinated. The most promising strategy — giving mom a dose of the pertussis vaccine toward the end of her pregnancy — means getting a booster in every pregnancy. The booster, called Tdap, actually protects against tetanus, diphtheria and pertussis. (Source: Forbes.com Healthcare News)






Direct Detection of Erythromycin-Resistant Bordetella pertussis in Clinical Specimens by PCR [Bacteriology]

Fri, 16 Oct 2015 00:00:00 +0100

Resistance of Bordetella pertussis to erythromycin has been increasingly reported. We developed an allele-specific PCR method for rapid detection of erythromycin-resistant B. pertussis directly from nasopharyngeal (NP) swab samples submitted for diagnostic PCR. Based on the proven association of erythromycin resistance with the A2047G mutation in the 23S rRNA of B. pertussis, four primers, two of which were designed to be specific for either the wild-type or the mutant allele, were used in two different versions of the allele-specific PCR assay. The methods were verified with results obtained by PCR-based sequencing of 16 recent B. pertussis isolates and 100 NP swab samples submitted for diagnostic PCR. The detection limits of the two PCR assays ranged from 10 to 100 fg per reaction for bo...

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Viral and atypical bacterial aetiologies of infection in hospitalised patients admitted with clinical suspicion of influenza in Thailand, Vietnam and Indonesia

Tue, 13 Oct 2015 00:00:00 +0100

ConclusionRespiratory viruses were the most commonly detected pathogens in patients hospitalised with a clinical suspicion of influenza. Rhinovirus was the most frequently detected virus, and M. pneumoniae, the most common atypical bacterium. The low number of detected influenza viruses demonstrates a low benefit for empirical oseltamivir therapy, unless during an influenza outbreak. (Source: Influenza and Other Respiratory Viruses)