Last Build Date: Tue, 29 Mar 2016 16:31:14 +0100
Sun, 20 Mar 2016 01:46:01 +0100Authors: Alam MS, Shrirao N Abstract A three-year-old boy presented to our oculoplastic clinic with complaints of painless gradually increasing right upper lid mass for the last 6 months. On examination a firm mass measuring roughly 1x1 cm was present on the upper lid. The mass was non tender with fine superficial vessels running over it. A differential diagnosis of epidermoid cyst, vascular malformation, pilomatrixoma, and juvenile xanthogranuloma was considered. The patient underwent excisional biopsy of the mass. On gross examination the mass had a brain like appearance. Histopathological examination confirmed the diagnosis of molluscum contagiosum. It is rare for molluscum contagiosum to present as a solitary lid tumor. A brain like appearance of the excised mass can provide a ...
Fri, 18 Mar 2016 00:00:00 +0100ConclusionGiven the poor quality of study design, wide array of outcome variables, and lack of objective evidence, no specific recommendation can be made for the treatment of MC in people infected with HIV, other than the initiation of ART. Despite the good impact ART has made on prevalence of dermatologic disease, MC remains an important cause of morbidity in HIV positive populations. (Source: International Journal of Dermatology)
Thu, 17 Mar 2016 00:00:00 +0100No need to treat molluscum contagiosum We often encounter the unmistakable molluscum contagiosum (MC) rash incidentally in our clinics, and parents may ask about treatment. It is caused by its own unique poxvirus and is highly contagious, but harmless. In the UK the advice is usually to leave well alone and await spontaneous resolution, but elsewhere treatment is often recommended. Researchers at Johns Hopkins in Baltimore, USA, reviewed 170 cases retrospectively (Basdag H, et al. Pediatric dermatology 2015. doi: 10.1111/pde.12504). Mean age at diagnosis was 5 years (range 1–15). 27% received some form of treatment, including various topical antivirals or locally destructive procedures such as cryotherapy. MC appeared to be more common in atopic children, particularly those with atop...
Sat, 12 Mar 2016 23:19:41 +0100Purpose of review: Pediatric skin and soft tissue infections (SSTIs) constitute a significant number of office-based pediatric visits. With SSTIs on the rise, it is not only important to effectively treat the individual, but to do so appropriately and cost-consciously. In this article, we highlight new research related to the treatment of bacterial skin infections, molluscum contagiosum, and cutaneous warts, with the goal of guiding pediatricians in their practice against these common skin conditions. Recent findings: Recent data supports the use of topical antibiotics for noncomplicated impetigo. Systemic antibiotics covering gram-positive cocci are recommended for complicated cases of impetigo and deeper nonpurulent SSTIs. Localized purulent bacterial SSTIs can be treated with incision ...
Sat, 12 Mar 2016 19:07:26 +0100Conclusions: In this cohort of HIV-infected international adoptees, severe immunosuppression was uncommon. Most medical issues were mild. Stunting was common at baseline but largely resolved. Mental health issues, behavioral problems, and educational delays were common. Most children were on ART at adoption and most of these showed suppressed VL. Non-nucleoside reverse transcriptase inhibitor mutations were present in most viremic children. (Source: The Pediatric Infectious Disease Journal)
Tue, 01 Mar 2016 00:00:00 +0100Conclusion: The pattern of dermatoses seen among the Nicobarese is quite similar with respect to the prevalence of infections in other regions of India, especially humid regions such as Assam, coastal Karnataka, and Kolkata and much higher than arid regions such as the deserts of Rajasthan. (Source: Indian Journal of Dermatology)
Wed, 24 Feb 2016 00:00:00 +0100Conclusion Both 10% KOH solution and 25% podophyllin solution are effective local therapies for the treatment of MC with comparable success rates (64% and 70% respectively). (Source: Journal of Dermatology and Dermatologic Surgery)
Wed, 10 Feb 2016 00:00:00 +0100Authors: Mira-Perceval Juan G, Alcalá Minagorre PJ, Betlloch Más I, Sánchez Bautista A PMID: 26874589 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Tue, 26 Jan 2016 00:00:00 +0100(Source: Dermatologic Therapy)
Thu, 21 Jan 2016 05:35:10 +0100A 45-year-old immunocompetent man presented with a 2-year history of a 0.5-mm smooth, white dome-shaped lesion on his bulbar conjunctiva (Fig 1, arrow). Following surgical excision of the lesion, histopathology (H&E and PAS) revealed lobular hyperplasia of epidermis resulting in a cup-shaped lesion (Fig 3, black arrow). Numerous, large homogeneous basophilic intracytoplasmic inclusion bodies (Henderson-Patterson corpuscles; Fig 2 arrows) were seen within the stratum granulosum and stratum corneum. (Source: Ophthalmology)
Fri, 15 Jan 2016 12:00:00 +0100A three-year-old boy presented to our oculoplastic clinic with complaints of painless gradually increasing right upper lid mass for the last 6 months. On examination a firm mass measuring roughly 1x1 cm was present on the upper lid. The mass was non tender with fine superficial vessels running over it. A differential diagnosis of epidermoid cyst, vascular malformation, pilomatrixoma, and juvenile xanthogranuloma was considered. The patient underwent excisional biopsy of the mass. On gross examination the mass had a brain like appearance. Histopathological examination confirmed the diagnosis of molluscum contagiosum. It is rare for molluscum contagiosum to present as a solitary lid tumor. A brain like appearance of the excised mass can provide a clue towards the diagnosis (Source: Dermatolo...
Wed, 13 Jan 2016 00:00:00 +0100Authors: Harrison ML, Desaulniers MA, Noyce RS, Evans DH Abstract The vaccinia virus I3L gene encodes a single-stranded DNA binding protein (SSB) that is essential for virus DNA replication and is conserved in all Chordopoxviruses. The I3 protein contains a negatively charged C-terminal tail that is a common feature of SSBs. Such acidic tails are critical for SSB-dependent replication, recombination and repair. We cloned and purified variants of the I3 protein, along with a homolog from molluscum contagiosum virus, and tested how the acidic tail affected DNA-protein interactions. Deleting the C terminus of I3 enhanced the affinity for single-stranded DNA cellulose and gel shift analyses showed that it also altered the migration of I3-DNA complexes in agarose gels. Microinjecting an...
Fri, 01 Jan 2016 12:00:00 +0100We describe the clinical and pathologic findings of a man who developed molluscum contagiosum of the eyelid while receiving methotrexate. We also review the characteristics of other patients with molluscum contagiosum acquired either during treatment with methotrexate or associated with human immunodeficiency virus (HIV) infection and summarize the unusual sites of presentation for the viral lesions in... (Source: Dermatology Online Journal)
Mon, 21 Dec 2015 08:21:55 +0100CONCLUSIONS: A single treatment of MC lesions with the pulsed dye laser successfully cured even recalcitrant lesions with no recurrence on follow up, and was well tolerated by the young subjects. PMID: 24155550 [PubMed] (Source: Laser Therapy)
Mon, 21 Dec 2015 00:00:00 +0100Conclusion The topical povidone-iodine/dimethylsulfoxide system is very effective in eradicating molluscum contagiosum. This novel combination warrants further investigation in randomized, controlled trials to further elucidate its clinical utility. (Source: Dermatology and Therapy)
Mon, 21 Dec 2015 00:00:00 +0100CONCLUSIONS: Most skin conditions in children have a "small" mean effect on quality of life. However, the range is large and a significant proportion of children with many common skin conditions will experience a very large effect on quality of life. This article is protected by copyright. All rights reserved. PMID: 26686685 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Fri, 11 Dec 2015 18:30:03 +0100CONCLUSIONS: Cryosurgery is still a valuable treatment of choice in various benign, premalignant, and malignant skin diseases but seems to be underused for indications other than viral warts. PMID: 26015777 [PubMed] (Source: Advances in Dermatology and Allergology)
Sun, 06 Dec 2015 00:00:00 +0100CONCLUSION: Consultations for MC in primary care are common, especially in 1-9-year-olds, but they declined significantly during the decade under study. A primary care diagnosis of AE is associated with an increased risk of a subsequent primary care diagnosis of MC. PMID: 26639950 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)
Mon, 30 Nov 2015 02:50:19 +0100Authors: Ramdass P, Mullick S, Farber HF Abstract In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human papilloma virus, hand, foot, and mouth disease, molluscum contagiosum, and Gianotti-Crosti syndrome. PMID: 26612372 [PubMed - in process...
Thu, 26 Nov 2015 00:00:00 +0100(Source: Pediatric Dermatology)
Wed, 25 Nov 2015 03:18:43 +0100In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human papilloma virus, hand, foot, and mouth disease, molluscum contagiosum, and Gianotti-Crosti syndrome. (Source: Primary Care: Clinics in Office Practice)
Fri, 20 Nov 2015 00:00:00 +0100With the now‐universal access to web‐based information, there is a need to provide clear, concise, and accurate medical information to patients and their families informing them about their medical conditions. Most practioners rely on electronic health records, and the ability to share information with patients in the form of “patients handouts” is easier than ever. Pediatric dermatologists, dermatologists, pediatricians, family practitioners, and internists diagnose a number of conditions in common and the SPD has initiated work on a patient handout database (found at http://pedsderm.net), aimed at disseminating reliable information to be used by these provider communities. The SPD will be publishing a new handout in each issue of Pediatric Dermatology. (Source: Pediatric Dermatol...
Wed, 18 Nov 2015 20:16:05 +0100Authors: Diaconu R, Oprea B, Vasilescu MM, Niculescu EC, Ciobanu MO, Diaconu C, Gheonea C, Stănescu GL Abstract The precise prevalence of molluscum contagiosum (MC) is still unknown. The pediatric studies showed a cumulative incidence of 17% in children less than 15 years, but there are no studies available for Romania. The papular skin lesions are generally less than 5 mm, but the immunocompromised patients may develop large uncommon lesions. The pediatric cases are located mostly on the limbs, trunk or the face. The lab investigations are not usually required because the clinical features are typical. A biopsy followed by a light microscopy may help in some cases. We are presenting the case of a 6-year-old boy suffering from MC since almost a year. When examined in our clinic, t...
Tue, 17 Nov 2015 00:00:00 +0100The objective of the current study was to examine the range of diagnoses among consultations at the Red Cross Children's Hospital in Cape Town, South Africa, to help develop a strategy for targeted education of primary health care personnel. This was a retrospective review of data for children seen at a pediatric dermatology clinic from 2005 to 2010, recorded according to International Classification of Diseases coding and compared with published data from similar clinical settings. There were 13,253 clinic visits, with 4,789 patients seen (median age 4.8 yrs, range 2 days to 18.6 yrs). The top 10 diagnoses accounted for 88.5% of consultations (59.5% atopic eczema [AE], 7.1% seborrheic dermatitis [SD], 4.2% superficial mycoses, 3.1% molluscum contagiosum, 2.8% vitiligo, 2.7% viral warts, 2...
Thu, 05 Nov 2015 00:00:00 +0100Conclusion: There is a need to emphasize on training the management of common pediatric dermatoses to dermatologists, general practitioners and pediatricians for early treatment. (Source: Indian Journal of Dermatology)
Wed, 04 Nov 2015 00:00:00 +0100(Source: The Breast Journal)
Sun, 01 Nov 2015 00:00:00 +0100ConclusionsMost skin conditions in children have a “small” mean effect on quality of life. However, the range is large and a significant proportion of children with many common skin conditions will experience a very large effect on quality of life.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Mon, 12 Oct 2015 00:00:00 +0100Conclusion: Viral STIs such as molluscum contagiosum, herpes genitalis, and condylomata acuminata are on the rise among STI/RTI clinic attendees. (Source: Indian Journal of Sexually Transmitted Diseases)
Wed, 07 Oct 2015 17:39:09 +0100This report suggests that some MF patients may experience Koebner phenomenon-induced MF lesions and that MF should be added to the long list of skin diseases potentially exhibiting the Koebner phenomenon.Case Rep Dermatol 2015;7:287-291 (Source: Case Reports in Dermatology)
Wed, 16 Sep 2015 00:00:00 +0100By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Clinical Practice Center: Image … (Source: Physician's First Watch current issue)
Wed, 26 Aug 2015 00:00:00 +0100Authors: Arroyo Mühr LS, Bzhalava D, Lagheden C, Eklund C, Johansson H, Forslund O, Dillner J, Hultin E Abstract Condylomata acuminata is caused by human papillomavirus (HPV). PCR with consensus primers will typically detect HPV in >96% of condylomata. Metagenomic sequencing has found that some "HPV-negative" condylomata do indeed contain HPV. We wished to perform a renewed evaluation of the "HPV-negative" condylomata using deeper metagenomics sequencing. Sequencing of whole genome amplified DNA from 40 apparently "HPV-negative" condylomata detected HPV in 37/40 specimens. We found 75 different HPV types, out of which 43 represented novel putative HPV types. Three types were cloned and established as HPV types 200, 201 and 202. Molluscum contagiosum virus was detected in 24 of ...
Fri, 14 Aug 2015 00:00:00 +0100CONCLUSION: In long-standing keratoconjunctivitis refractory to treatment, special attention should be paid to the possible presence of molluscum contagiosum, particularly in children and the lesions should be promptly removed. PMID: 26271738 [PubMed - as supplied by publisher] (Source: Der Ophthalmologe)
Wed, 12 Aug 2015 00:00:00 +0100ConclusionsBerEP4 and PHLDA1 were consistently expressed in the areas of primitive follicular induction surrounding lesions of MC. CK 20 stained the Merkel cells present in the basaloid buds. All these findings support the reactive origin of this phenomenon, which we believe is most probably viral‐induced. (Source: Journal of Cutaneous Pathology)
Sat, 08 Aug 2015 00:00:00 +0100Authors: Kumar P, Savant SS PMID: 26388647 [PubMed - in process] (Source: Indian Pediatrics)
Thu, 06 Aug 2015 00:00:00 +0100Molluscum Contagiosum (MC) is a skin infection caused by a double-stranded DNA virus of the family Poxviridae1 that replicates in the human epidermis enhancing cell mitosis and disrupting epidermal cell differentiation by the upregulation of the expression of epidermal growth factor receptor.2 There are two different strains of the virus MCV-1 and MCV-2, both universally distributed.3 Common affected areas are the trunk, armpit and genital area,4 rarely affecting the palms of the hands and soles of the feet or mucous membranes;2 it has two peaks of incidence, one during the first years of life (1 to 5 years of age) and the other one in sexually active young adults3 with no difference between sexes; vertical transmission has also been reported as congenital disease. (Source: International J...
Thu, 06 Aug 2015 00:00:00 +0100(Source: International Journal of Infectious Diseases)
Wed, 05 Aug 2015 00:00:00 +0100This case report illustrates how erythema annulare centrifugum may manifest as a reaction pattern induced by molluscum contagiosum. (Source: JAMA Dermatology)
Sat, 01 Aug 2015 00:00:00 +0100Authors: Allmon A, Deane K, Martin KL Abstract Because childhood rashes may be difficult to differentiate by appearance alone, it is important to consider the entire clinical presentation to help make the appropriate diagnosis. Considerations include the appearance and location of the rash; the clinical course; and associated symptoms, such as pruritus or fever. A fever is likely to occur with roseola, erythema infectiosum (fifth disease), and scarlet fever. Pruritus sometimes occurs with atopic dermatitis, pityriasis rosea, erythema infectiosum, molluscum contagiosum, and tinea infection. The key feature of roseola is a rash presenting after resolution of a high fever, whereas the distinguishing features in pityriasis rosea are a herald patch and a bilateral and symmetric rash in ...
Thu, 30 Jul 2015 00:00:00 +0100A 5-year-old boy presented with a 2-week history of a left, painful red eye despite treatment with chloramphenicol drops. Examination revealed conjunctival ulceration associated with localized injection but no follicular reaction (Figure, A). No eyelid or facial cutaneous lesions were present. Conjunctival swabs were negative. (Source: The Journal of Pediatrics)
Tue, 21 Jul 2015 15:13:33 +0100Abstract: Langerhans cell histiocytosis (LCH) carries a prognosis, which ranges from benign to potentially fatal. There is currently little framework to decipher metrics, which predict the benign versus aggressive nature of LCH. We wanted to determine whether molluscum contagiosum virus (MCV) DNA could be isolated from a cutaneous lesion, demonstrating Langerhans cell hyperplasia resembling LCH in a patient with both. Polymerase chain reaction on biopsy-proven MCV and the hyperplastic lesion has been performed. Two specific regions within the MCV genome were detected from both biopsies. The authors report our findings and suggest that some MCV can produce histological lesions resembling LCH, similar to the literature on scabies mimicking LCH. Efforts to find a reactive “driver” in LCH ...
Sat, 27 Jun 2015 00:47:20 +0100We report a molluscum contagiosum around the vulva and anus of 9-year-old girl, which has atypical presentations and was finally confirmed by histopathological and electron microscopy findings. (Source: Anais Brasileiros de Dermatologia)
Wed, 24 Jun 2015 00:00:00 +0100We describe here two siblings with a novel STK4 mutation identified during the evaluation of a group of patients with features highly overlapping with those of DOCK-8 deficiency, a form of AR hyperimmunoglobulin E syndrome. The patients` clinical features include autoimmune cytopenias, viral skin infections (molluscum contagiosum and perioral herpetic infection), mild fungal nail infections, mild atopic dermatitis, seborrheic dermatitis, lymphopenia (particularly CD4 lymphopenia), and intermittent mild neutropenia. Determination of the underlying defect and reporting the patients are required for the description of the phenotypic spectrum of each immunodeficiencies. PMID: 26117625 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Thu, 04 Jun 2015 00:00:00 +0100ConclusionsPerilesional fibroedematous to fibromyxoid stroma and keratinocyte changes, including prominent nucleoli and amphophilic cytoplasm with clear vacuolization, are common in MC. Recognizing these features may prove helpful in reaching the diagnosis of MC in cases lacking classic histopathological features on initial sections. (Source: Histopathology)
Wed, 29 Apr 2015 00:00:00 +0100A literature review and clinical commentary on diagnosis and treatment of common childhood bacterial, fungal and viral skin infections is presented including impetigo, folliculitis, staphylococcal scalded skin syndrome, tinea capitis, warts and molluscum contagiosum. (Source: Journal of Infection)
Wed, 29 Apr 2015 00:00:00 +0100A literature review and clinical commentary on diagnosis and treatment of common childhood bacterial, fungal and viral skin infections is presented including impetigo, folliculitis, staphylococcal scalded skin syndrome, tinea capitis, warts and molluscum contagiosum. (Source: Journal of Infection)
Mon, 27 Apr 2015 00:25:13 +0100Discussion The differential diagnosis of diaper dermatitis is usually fairly easy with irritant, fungal and bacterial causes being the most common. These are usually easily treated with resolution. When it is not improving then the differential must be expanded and other disease processes must be considered. These again usually include problems that are relatively easily treated such as scabies, lice or tinea. Other much less likely conditions in this age group would be syphilis or granuloma inguinale. Other signs or symptoms need to also be considered as Crohn’s disease, histocytosis or acrodermatitis enteropathica can present as a diaper rash also. A review of rashes by distribution and pattern can be seen here. Learning Point Jacquet erosive diaper dermatitis (JED) is a severe i...
Fri, 17 Apr 2015 00:00:00 +0100ConclusionPerilesional fibroedematous to fibromyxoid stroma and keratinocyte changes including prominent nucleoli and amphophilic cytoplasm with clear vacuolization are common in MC. Recognizing these features may prove helpful in reaching the diagnosis of molluscum in cases lacking classic histopathologic features on initial sections.This article is protected by copyright. All rights reserved. (Source: Histopathology)
Fri, 20 Mar 2015 00:00:00 +0100A 3-year-old boy presented to our dermatology department in July, 2013, with a history of moderate atopic dermatitis, food allergy to cow's milk protein and hen's egg, and a 4 week history of very extensive molluscum contagiosum. Initial treatment with topical cantharidin and imiquimod had been unsuccessful. The family had no history of immunodeficiency. Investigations showed lymphopenia with abnormal T-cell subsets (CD4 lymphocyte count of 0·384 × 109 cells per L [normal range 0·5–2·4 × 109 cells per L], CD3 lymphocyte count of 0·462 × 109 cells per L [0·9–4·5 × 109 cells per L], and CD8 lymphocyte count of 0·074 × 109 cells per L [0·3–1·6 × 109 cells per L]), increased IgE (2567 kIU/L [ (Source: LANCET)
Thu, 05 Mar 2015 13:59:56 +0100CONCLUSIONS: LEF has previously been reported to be a useful immune modulator for the treatment of severe atopic dermatitis. The spectrum of anti-viral effects previously seen with leflunomide did appear beneficial in these patients in clearing verrucae and MC, which had been resistant to conventional therapies while the patients were on azathioprine.
Sun, 01 Mar 2015 00:00:00 +0100We present a brief observational report of clearance of significant molluscum contagiosum infection in a child taking methotrexate after one dose of intramuscular zoster immunoglobulin‐VF (human) and suggest that this may indicate a potential new treatment option. (Source: Pediatric Dermatology)
Wed, 18 Feb 2015 00:00:00 +0100Publication date: 2015 Source:Advances in Virus Research, Volume 92 Author(s): Joanna L. Shisler Molluscum contagiosum virus (MCV) is the causative agent of molluscum contagiosum (MC), the third most common viral skin infection in children, and one of the five most prevalent skin diseases worldwide. No FDA-approved treatments, vaccines, or commercially available rapid diagnostics for MCV are available. This review discusses several aspects of this medically important virus including: physical properties of MCV, MCV pathogenesis, MCV replication, and immune responses to MCV infection. Sequencing of the MCV genome revealed novel immune evasion molecules which are highlighted here. Special attention is given to the MCV MC159 and MC160 proteins. These proteins are FLIPs with homologs in gamm...
Wed, 18 Feb 2015 00:00:00 +0100(Source: Pediatric Dermatology)
Fri, 30 Jan 2015 00:00:00 +0100In this report we review our experience with the demographic characteristics, clinical characteristics, management, and time to resolution of MC in 170 children. A retrospective medical chart review and telephone survey were conducted on children younger than 16 years of age evaluated for MC in the Division of Pediatric Dermatology at the Johns Hopkins Children's Center, Baltimore, Maryland, from January 1, 2008, to December 31, 2011. Of 170 children with MC, 51.8% were female and 77.1% were Caucasian. The median age at diagnosis was 5 years and 46.5% had a history of atopic dermatitis (AD). Children with AD had significantly more MC lesions than those without (p < 0.05); 72.9% of children did not receive any treatment. MC lesions completely cleared within 12 months in 45.6% of trea...
Sat, 24 Jan 2015 01:01:21 +0100CONCLUSIONS: PDL offers a novel and effective treatment for MC. However, the articles reviewed herein suggest PDL is a safe, effective, quick and well-tolerated treatment for clearing MC lesions that does not cause scarring or permanent pigment change.
Sun, 18 Jan 2015 00:00:00 +0100We report a widely disseminated, disfiguring facial molluscum contagiosum (MC) as a presenting complaint in an 11-year-old girl secondary to human immune-deficiency virus infection. A biopsy specimen demonstrated lobulated epidermal growth consisting of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies. The patient was treated with highly active anti-retroviral therapy (HAART). The extent of MC in our patient was remarkable and subsequently improved dramatically after starting HAART. Normally MC does not similarly respond in patients with AIDS. PMID: 25601890 [PubMed - as supplied by publisher] (Source: Tropical Doctor)
Wed, 14 Jan 2015 00:00:00 +0100“Half of what we’re teaching you is wrong,” one of my medical school deans would often say. “The problem,” he would continue, “is that we don’t know which half.” (Source: JAMA Dermatology)
Wed, 14 Jan 2015 00:00:00 +0100Publication date: Available online 13 January 2015 Source:Advances in Virus Research Author(s): Joanna L. Shisler Molluscum contagiosum virus (MCV) is the causative agent of molluscum contagiosum (MC), the third most common viral skin infection in children, and one of the five most prevalent skin diseases worldwide. No FDA-approved treatments, vaccines, or commercially available rapid diagnostics for MCV are available. This review discusses several aspects of this medically important virus including: physical properties of MCV, MCV pathogenesis, MCV replication, and immune responses to MCV infection. Sequencing of the MCV genome revealed novel immune evasion molecules which are highlighted here. Special attention is given to the MCV MC159 and MC160 proteins. These proteins are FLIPs with...
Mon, 29 Dec 2014 00:00:00 +0100We report the occurrence of Staphylococcus lugdunensis abscesses in two girls with molluscum contagiosum who both required surgical intervention under general anaesthesia. S. lugdunensis is a coagulase‐negative Staphylococcus recently recognized as an emerging human pathogen. Because of its ubiquitous nature and the high prevalence of molluscum contagiosum in children, it is likely that this as yet unreported association may be underestimated, thus raising the question as to whether bacterial culture of superinfected mollusca should be obtained more often. (Source: Pediatric Dermatology)
Fri, 26 Dec 2014 00:00:00 +0100Conclusions: ATL manifest in myriad presentations and skin lesions are often the earliest manifestation. Cutaneous manifestations of ATL vary from subtle hypopigmented macules to florid nodular lesions, and HTLV-1 screening need to be carried out in all doubtful cases. (Source: Indian Journal of Dermatology)
Tue, 23 Dec 2014 00:00:00 +0100Molluscum contagiosum, a common viral cutaneous infection in children, is caused by a poxvirus of the molluscipox genus. The infection accounts for roughly 1% of all diagnosed skin disorders.1 Despite its common occurrence, little has been published on the natural history of molluscum contagiosum.2–4 The natural history can be deduced from the time the lesions initially appear until the time of documented spontaneous resolution of the lesions. (Source: The Lancet Infectious Diseases)
Tue, 23 Dec 2014 00:00:00 +0100One in ten children with molluscum contagiosum is likely to have a substantial effect on their quality of life and therefore treatment should be considered for some children, especially those with many lesions or who have been identified as having a severe effect on quality of life. Patients with molluscum contagiosum and their parents need to be given accurate information about the expected natural history of the disorder. Our data provide the most reliable estimates of the expected time to resolution so far and can be used to help set realistic expectations. (Source: The Lancet Infectious Diseases)
Tue, 02 Dec 2014 05:17:28 +0100This article reviewed the literature regarding risk of systemic toxicity associated with use of EMLA in the pediatric and adult population. All 12 clinical trials evaluating the safety of EMLA in either the pediatric or adult population generally followed dosing and administration guidelines set by the manufacturer and reported clinically insignificant plasma levels of methemoglobin, lidocaine, prilocaine, and their respective metabolites. To date, nine pediatric cases and three adult cases of systemic toxicity associated with EMLA have been published. Possible factors that contributed to the development of systemic toxicity include excessive amount of EMLA, large application area, prolonged application time, diseased and/or inflamed skin (eg, vascular malformations, molluscum contagiosum,...
Mon, 01 Dec 2014 00:00:00 +0100In conclusion, molluscum bodies are protected from host immune responses and apoptotic signals by being surrounded by LC‐depleted epidermal walls and viral immunosuppressive molecules, but could be eradicated by reagents inducing p53‐dependent apoptosis. (Source: The Journal of Dermatology)
Mon, 01 Dec 2014 00:00:00 +0100(Source: Journal of Paediatrics and Child Health)
Thu, 13 Nov 2014 00:00:00 +0100Publication date: October 2014 Source:Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Volume 26, Issue 4 Author(s): Gautam Bir Singh , Sunil Garg , Rubeena Arora , Deepak Kumar , Anita Nangia , Geetika Sharma Intraoral molluscum contagiosum is an extremely rare clinical entity with only seven cases reported till date in the world medical literature. This clinical record documents the first case of the said lesion in tongue in an immunocompetent female of 35 years old, who was treated surgically. In addition this case report also reviews the scant medical literature on the cited subject. With this case, we illustrate a rare entity that present in an extremely rare manner. (Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology)
Tue, 11 Nov 2014 00:00:00 +0100Abstract Inflammation in atopic dermatitis is mediated in part by the chemokine CCL1 and its receptor, CCR8. Recombinant Molluscum contagiosum viral protein (rMC148p), a cc-chemokine homolog, inhibits CCL1-induced chemotaxis of cells expressing CCR8. rMC148p was prepared using the baculovirus/Sf9 insect cell expression system. The recombinant MC148 fusion protein (rMC148fp), rMC148-TAT-6xHis, was similarly prepared by adding base sequences onto the PCR primers to fuse TAT and 6xHis to rMC148p at the carboxyl terminus. rMC148fp retains the capacity of rMC148p to inhibit CCL1-induced chemotaxis. Furthermore, unlike rMC148p, topically applied rMC148fp penetrates stratum corneum of human neonatal foreskins and concentrates along the basal and lower spinous cell layers of the epidermis...
Wed, 15 Oct 2014 07:00:00 +0100Title: Molluscum ContagiosumCategory: Diseases and ConditionsCreated: 3/14/2014 12:00:00 AMLast Editorial Review: 10/15/2014 12:00:00 AM (Source: MedicineNet Hepatitis C General)
Sun, 12 Oct 2014 00:00:00 +0100A 2-year-old girl presented with a 3-month history of several small painless papules, growing on the surface of an abdominal congenital melanocytic naevus (MN). Her mother noted that the lesions were significantly increasing in number and size. There was no history of trauma and her medical and family histories were unremarkable. Physical examination revealed multiple skin-coloured, translucent, glossy, dome-shaped papules, ranging from 1 to 3 mm, localised exclusively on the surface of a macular, smooth, light to dark brown, non-hypertrichotic congenital intermediate MN (2x4 cm) (see figure 1). The dermoscopic examination of the papules suggested the diagnosis of molluscum contagiosum (MC), which was histologically confirmed. MC is a common viral skin infection, which is seldom ...
Sun, 12 Oct 2014 00:00:00 +0100Conclusion The efficiency of the 532nm laser is comparable with the dye laser, but the 532nm laser is lower in price and more commonly available than the dye laser. We recommend further prospective studies about the 532nm laser in the treatment of molluscum contagiosum. (Source: Medical Laser Application)
Tue, 07 Oct 2014 00:38:24 +0100Aisha Saim (pictured left), 4, has molluscum contagiosum — a very common childhood skin condition caused by a virus. It is common in pre-school and early primary school years. (Source: the Mail online | Health)
Wed, 01 Oct 2014 00:00:00 +0100Authors: Foissac M, Goehringer F, Ranaivo IM, May T, Cuny JF, Schmutz JL, Lekaditi M PMID: 25288067 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)
Tue, 30 Sep 2014 11:44:31 +0100Conclusion We reveal the third CORO1A-mutated kindred, with the immune phenotype of abnormal naïve CD4 and DN T-cells and newfound characteristics of a late/hypomorphic-like SCID of an EV-HPV mucocutaneous syndrome with also B and NK defects and shortened telomeres. Our findings contribute to the elucidation of the CORO1A-SCID-CID spectrum. (Source: Journal of Clinical Immunology)
Mon, 08 Sep 2014 00:01:37 +0100Discussion Infectious exanthams are usually considered when rashes are bilateral, symmetric and relatively widespread. They usually involve the trunk too and have associated systemic symptoms. Gianotti-Crosti syndrome (GCS) or acropapular dermatitis of childhood is often misdiagnosed because it doesn’t follow these rules. A discussion of common viral exanthams can be reviewed here and a differential diagnosis of rashes by pattern and distributions can be reviewed here. Dr. Ferdinando Gianotti came from a poor family, underwent several personal tragedies, but entered medicine and created the first department of pediatric dermatology in Italy (possibly in Europe). He became interested in a child with papular eruption that he could not classify and after seeing several other cases over...
Wed, 03 Sep 2014 00:00:00 +0100ConclusionWe report the original observation of a patient with stage IV Sezary syndrome, who presented multiple molluscum contagiosum, spread and surrounded by a pale halo, without inflammation, eczema or disappearance of melanocytes. This halo could be due to the secretion of a protein by molluscum contagiosum inhibiting inflammation around this MC. To our knowledge, this phenomenon reported in a patient with severe atopic dermatitis associated with Sezary syndrome has not previously been described. (Source: Journal of the European Academy of Dermatology and Venereology)
Wed, 06 Aug 2014 00:00:00 +0100We read with interest the article by Demaria et al1 as pubic hair removal has gained more popularity in recent years. Various methods of hair removal may also be associated with sexually transmitted diseases. Primary genital herpes from contamination from a waxing salon has been described in the literature.2 Cases of molluscum contagiosum outbreak and septic shock due to staphylococcal infection are yet other complications of pubic waxing.3 Contamination of waxing tools such as a spatula from a previously infected patient or the individual performing it rather than the waxing tub are more likely causes of transmission of herpetic infection, or even a shingles outbreak in a patient under significant stress. (Source: American Journal of Obstetrics and Gynecology)
Fri, 01 Aug 2014 00:00:00 +0100CONCLUSION: The MCDTP performed well compared with GP diagnosis and is suitable for clinical use by parents and in population-based studies. PMID: 25071059 [PubMed - in process] (Source: The British Journal of General Practice)
Fri, 01 Aug 2014 00:00:00 +0100Authors: Piaserico S, Sandini E, Peserico A, Alaibac M Abstract Cutaneous infections might occur in up to 80% of organ transplant recipients (OTR) and viral infections are the most common them. The risk of different skin infection is among related to the intensity of immunosuppression. During the first post-transplant period, herpes viruses are most common. After some months following transplantation, human papilloma viruses represent the most significant infections among OTR. Reactivation of herpes simplex virus in OTR can become more invasive, takes longer to heal, and shows greater potential for dissemination to visceral organs compared to the general population. Specific immunosuppressive drugs (namely muromonab and mycophenolate mofetil) have been associated with an increased ...
Tue, 22 Jul 2014 00:00:00 +0100Abstract Molluscum contagiosum (MC) is a common viral infection of the skin and mucous membrane that often affects young children. Generally, physical removal by surgical curettage is commonly used for the treatment of MC, but the pain during the treatment is a major problem. Thus immunotherapy using various antigens has been introduced recently. Here we present two cases of MC that improved with measles, mumps, and rubella (MMR) vaccine intralesional injection. On the ground of our knowledge, they were the first cases of successful MMR intralesional injection in this disease entity. (Source: Dermatologic Therapy)
Mon, 07 Jul 2014 14:25:07 +0100Summer is the prime time for molluscum contagiosum, a highly contagious viral skin condition that is on the rise and infects over a million children in the USA each year according to...(PRWeb July 07, 2014)Read the full story at http://www.prweb.com/releases/2014/07/prweb11994688.htm (Source: PRWeb: Medical Pharmaceuticals)
Tue, 01 Jul 2014 00:00:00 +0100We describe a 12-year-old boy with autism who was thought to have widespread molluscum contagiosum for a year before dermatologic consultation was obtained. Recognition of eruptive xanthomas led to the discovery of massive hypertriglyceridemia (serum triglycerides 6853 mg/dL) and diabetes mellitus. Through medical intervention, including insulin and fenofibrate therapy, and dietary modification with weight loss, the xanthomas cleared during the subsequent months, and his serum triglyceride levels nearly normalized. (Source: PEDIATRICS)
Wed, 25 Jun 2014 00:00:00 +0100(Source: International Journal of Dermatology)
Sun, 22 Jun 2014 15:45:03 +0100We report a case of a high school wrestler who presented with molluscum lesions on his neck. PMID: 24945653 [PubMed - in process] (Source: Dermatol Online J)
Sun, 22 Jun 2014 15:45:03 +0100Conclusion: Topical cantharidin is a safe and effective treatment for warts, molluscum contagiosum, and callus removal, with promising uses in perforating dermatoses and leishmaniasis. PMID: 24945640 [PubMed - in process] (Source: Dermatol Online J)
Tue, 20 May 2014 00:00:00 +0100We report a case of stage IV proximal‐type ES that mimicked molluscum contagiosum clinically and was histopathologically reminiscent of invasive squamous cell carcinoma because of attachment and colonization of the overlying epidermis. The case represents an unusual pathologic presentation of ES and highlights potential pitfalls in establishing the diagnosis. (Source: Journal of Cutaneous Pathology)
Tue, 13 May 2014 00:00:00 +0100(Source: Clinical And Experimental Dermatology)
Mon, 12 May 2014 00:00:00 +0100Yeliz Karakoca Basaran, Enver Turan, Baris Keklik, Emine Zeynep TariniIndian Journal of Dermatology, Venereology, and Leprology 2014 80(3):278-278 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Thu, 01 May 2014 11:25:06 +0100Zymaderm™, the most widely used painless and inexpensive natural topical treatment for molluscum contagiosum In the United States, has filed for a CE Mark to market and sell throughout the European...(PRWeb April 30, 2014)Read the full story at http://www.prweb.com/releases/2014/05/prweb11808474.htm (Source: PRWeb: Medical Pharmaceuticals)
Thu, 01 May 2014 00:00:00 +0100(Source: Journal of the American Academy of Dermatology)
Sun, 27 Apr 2014 21:40:02 +0100We present a case of a perforating pilomatricoma presenting as a cutaneous horn in an 11 year old girl. PMID: 24746308 [PubMed - in process] (Source: Dermatol Online J)
Fri, 25 Apr 2014 16:22:52 +0100CONCLUSION: Topical 5% potassium hydroxide presents an effective, safe, and low-cost treatment modality for genital warts in men and should be included in the spectrum of therapies for genital warts. (Source: Anais Brasileiros de Dermatologia)
Mon, 21 Apr 2014 03:46:52 +0100In a Review of treatment options for molluscum contagiosum infection, Xiaoying Chen and colleagues include imiquimod, citing three small randomised controlled trials and observational data as evidence of its effectiveness. They do not note that findings from two large, well designed, randomised trials (1494-IMIQ and 1495-IMIQ), completed in 2006 but to date unpublished, definitively showed that imiquimod does not effectively treat molluscum contagiosum in children. The two trials together enrolled 702 participants aged 2–12 years, of whom 470 were randomly assigned to imiquimod 5% cream. (Source: The Lancet Infectious Diseases)
Thu, 17 Apr 2014 21:12:26 +0100Molluscum contagiosum (MC) is a common and benign contagious viral skin condition of childhood that accounts for approximately 1% of all diagnoses of skin disorders and up to 10% of skin disorder diagnoses in the pediatric population (Source: Journal of the American Academy of Dermatology)
Tue, 08 Apr 2014 17:15:06 +0100CVS, the largest health care provider in the U.S., has selected ZymaDerm™, the most widely used painless topical treatment for molluscum contagiosum, for sale at its local drugstores. Now it's...(PRWeb April 08, 2014)Read the full story at http://www.prweb.com/releases/2014/04/prweb11739712.htm (Source: PRWeb: Medical Pharmaceuticals)
Tue, 01 Apr 2014 00:00:00 +0100Authors: Nguyen HP, Tyring SK Abstract Molluscum contagiosum is a poxvirus infection of the skin that is commonly observed in children. The molluscum contagiosum virus (MCV) expresses several gene-products that are involved in its pathogenesis and evasion of the host immune system. MCV can be transmitted both to other sites of the body and to other individuals through direct physical contact as well as fomites. While diagnosis is generally straightforward clinically, management of molluscum contagiosum is controversial. Several treatment options are available for the destruction of individual lesions, but there is insufficient evidence for therapeutic intervention being any more effective than natural, spontaneous resolution. Complex cases, such as infection occurring in immunocomp...
Wed, 26 Mar 2014 00:00:00 +0100Shivani Bansal, Vineet Relhan, Esha Roy, Vijay Kumar Garg, Nita KhuranaIndian Journal of Dermatology, Venereology, and Leprology 2014 80(2):179-180 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Fri, 21 Mar 2014 00:00:00 +0100Conclusions. MC is a common condition, with the greatest incidence being in those aged 1–4 years. Swimming and eczema are associated with the presence of MC, but the causal relationships are unclear. There is a lack of data regarding the natural history of MC and published data are insufficient to determine temporal or geographic patterns in incidence, risk factors, duration of symptoms or transmission between family members. (Source: Family Practice)
Sat, 01 Mar 2014 00:00:00 +0100We report a case of stage IV proximal‐type ES that mimicked molluscum contagiosum clinically and was histopathologically reminiscent of invasive squamous cell carcinoma because of attachment and colonization of the overlying epidermis. The case represents an unusual pathologic presentation of ES and highlights potential pitfalls in establishing the diagnosis. (Source: Journal of Cutaneous Pathology)
Tue, 25 Feb 2014 00:01:00 +0100EACH week family GP Dr Rosemary Leonard addresses your medical questions. Here she addresses whether the virus molluscum contagiosum can strike twice and how to handle forgetfulness after experiencing a fall (Source: Daily Express - Health)
Tue, 25 Feb 2014 00:01:00 +0100EACH week family GP Dr Rosemary Leonard addresses your medical questions. Here she answers questions about pink bumps from molluscum contagiosum and memory loss after experiencing a fall. (Source: Daily Express - Health)
Fri, 21 Feb 2014 20:59:46 +0100Abstract: Dermatoscopy as a non-invasive technique has become an integrative part in the evaluation of pigmented and non-pigmented skin lesions, particularly for the early detections of melanoma. Although dermatoscopy improves diagnosis of pigmented and nonpigmented lesions of the skin, it is unknown if dermatoscopy improves the diagnostic accuracy of pigmented mucosal lesions. The “entodermatoscopy” is used for the dermatoscopy of skin infections and infestations and revised as entomodermatoscopy, as it connects the research fields of dermatology and entomology, with its roots being found in these two words. In genital dermatology along with the clinical examination, dermatoscopy is also used for the diagnosis and treatment follow-up of pediculosis pubis, genital warts, molluscum cont...