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MedWorm: Erythema Infectiosum



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Erythema Infectiosum category.



Last Build Date: Tue, 29 Mar 2016 16:33:42 +0100

 



Zmiany rodzaju koncentratu czynnika krzepnięcia u chorego na hemofilię – korzyść czy ryzyko?

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: Available online 19 March 2016 Source:Acta Haematologica Polonica Author(s): Anna Klukowska Patients with haemophilia are treated with a variety of coagulation factor concentrates. They usually change concentrate types many times during their lifetime for different, often independent, reasons. Since recombinant coagulation factor concentrates VIII and IX became available, some patients in well-developed countries have started using these products instead of previously applied plasma-derived concentrates. At the moment, there are different types of concentrates available, including first, second and third generation recombinant concentrates, and factor VIII concentrates with full length or B deleted domain molecule. The drug's efficacy and safety are both taken into con...

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Autoimmune Hemolytic Anemia Triggered by Infection with Human Parvovirus B19 after Total Abdominal Colectomy for Ulcerative Colitis.

Fri, 18 Mar 2016 23:15:02 +0100

Authors: Iida T, Satoh S, Nakagaki S, Shimizu H, Kaneto H Abstract A 50-year-old man was admitted to our hospital for an adhesive ileus 14 years after total abdominal colectomy for ulcerative colitis (UC). The ileus decreased with conservative treatment, however, autoimmune hemolytic anemia (AIHA) was diagnosed due to worsening anemia, a positive direct Coombs test, low haptoglobin, high lactase dehydrogenase, reticulocytosis, and an increase in the erythroblastic series in a bone-marrow examination. Human parvovirus B19 (PV-B19) IgM and PV-B19 DNA were present, indicating the development of AIHA triggered by an infection with PV-B19. The patient is currently being monitored after spontaneous remission. This is the first report of UC after total abdominal colectomy complicated by A...



The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease

Thu, 17 Mar 2016 00:00:00 +0100

Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been sho...



Toxoplasmosis, Parvovirus, and Cytomegalovirus in Pregnancy

Tue, 08 Mar 2016 00:00:00 +0100

This article reviews the modes of transmission as well as maternal and neonatal effects of each of these infections. In addition, the article outlines recommended testing, fetal surveillance, and treatment where indicated. (Source: Clinics in Laboratory Medicine)



Viruses, Vol. 8, Pages 61: The Receptor-Binding Domain in the VP1u Region of Parvovirus B19

Wed, 24 Feb 2016 00:00:00 +0100

Parvovirus B19 (B19V) is known as the human pathogen causing the mild childhood disease erythema infectiosum. B19V shows an extraordinary narrow tissue tropism for erythroid progenitor cells in the bone marrow, which is determined by a highly restricted uptake. We have previously shown that the specific internalization is mediated by the interaction of the viral protein 1 unique region (VP1u) with a yet unknown cellular receptor. To locate the receptor-binding domain (RBD) within the VP1u, we analyzed the effect of truncations and mutations on the internalization capacity of the recombinant protein into UT7/Epo cells. Here we report that the N-terminal amino acids 5–80 of the VP1u are necessary and sufficient for cellular binding and internalization; thus, this N-terminal region represen...



Possible involvement of miRNAs in tropism of Parvovirus B19.

Fri, 19 Feb 2016 01:11:02 +0100

Authors: Anbarlou A, AkhavanRahnama M, Atashi A, Soleimani M, Arefian E, Gallinella G Abstract Human Parvovirus B19 (PVB19) is one of the most important pathogens that targets erythroid lineage. Many factors were mentioned for restriction to erythroid progenitor cells (EPCs). Previous studies showed that in non-permissive cells VP1 and VP2 (structural proteins) mRNAs were detected but could not translate to proteins. A bioinformatics study showed that this inhibition might be due to specific microRNAs (miRNAs) present in non-permissive cells but not in permissive EPCs. To confirm the hypothesis, we evaluated the effect of miRNAs on VP expression. CD34(+) HSCs were separated from cord blood. Then, CD34(+) cells were treated with differentiation medium to obtain CD36(+) EPCs. To eval...

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[Bicytopenia due to parvovirus b19 infection in octogenarian: a case report].

Tue, 16 Feb 2016 00:00:00 +0100

Authors: Jiménez-Rodríguez T, Romero-Pérez D, Andreu M, Ramos-Rincón JM PMID: 26888340 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)



Novel COL4A1 mutation in an infant with severe dysmorphic syndrome with schizencephaly, periventricular calcifications, and cataract resembling congenital infection

Tue, 16 Feb 2016 00:00:00 +0100

ConclusionWe suggest that COL4A1 testing should be considered in patients with schizencephaly as well as with phenotype suggesting TORCH infection without any proven etiological factors. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)



No evidence of persistent parvovirus B19 viremia among Iranian patients with HIV after a 1-year follow-up

Wed, 10 Feb 2016 00:00:00 +0100

In this study, we investigated virological and hematological findings, and also the clinical outcome, of seven cases of HIV/B19 coinfection (confirmed by PCR) after one year. These cases were provided from a previous study on patients with HIV infection that found B19 DNA in 13 cases. Seven of these 13 patients were available after 1 year, and we retested them for B19 viremia and B19-specific antibodies. B19 IgG was tested by ELISA, and B19 DNA was assessed by nested PCR. Anemia was not observed in these cases. All subjects had cleared viremia, but B19 IgG seroconversion occurred in two cases. No significant changes in CD4 and hemoglobin occurred. The results of this study indicate that B19 infection in HIV patients is a subtle infection and that B19 viremia is not a long-term event. (Sour...



Clinical Significance of Viral Genome Persistence in the Myocardium of Patients with Dilated Cardiomyopathy

Thu, 04 Feb 2016 21:04:03 +0100

Conclusions: High prevalence of a viral genome in the myocardium of patients with DCM did not have an influence on their long-term clinical outcome.Intervirology 2015;58:350-356 (Source: Intervirology)



Postinfectious glomerulonephritis secondary to Erythrovirus B19 (Parvovirus B19): case report and review of the literature.

Tue, 02 Feb 2016 00:00:00 +0100

Authors: Marco H, Guermah I, Matas L, Hernández A, Navarro M, Lopez D, Bonet J Abstract A previously healthy 32-yearold woman developed arterial hypertension, proteinuria, and hematuria (nephritic syndrome) with normal renal function and was diagnosed with post-infectious glomerulonephritis secondary to parvovirus B19 infection. The renal biopsy showed endocapillary glomerulonephritis, with positive IgG, C3, and C1q immunoreactivity in the capillary walls and ultrastructural evidence of subendothelial deposits. The diagnosis of parvovirus B19 infection was confirmed by IgG/IgM serological positivity and parvovirus DNA demonstration in both peripheral blood and kidney tissue. Glomerular involvement improved spontaneously. To be noted are the atypical signs and symptoms of our patie...

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Mutational characteristics of ANK1 and SPTB genes in hereditary spherocytosis.

Mon, 01 Feb 2016 00:00:00 +0100

Authors: Park J, Jeong DC, Yoo J, Jang W, Chae H, Kim J, Kwon A, Choi H, Lee JW, Chung NG, Kim M, Kim Y Abstract The aim of the present study was to describe the mutational characteristics in Korean hereditary spherocytosis(HS) patients. Relevant literatures including genetically confirmed cases with well-documented clinical summaries and relevant information was also reviewed to investigate the mutational gene- or domain-specific laboratory and clinical association. Twenty-five HS patients carried one heterozygous mutation of ANK1(n=13) or SPTB(n=12) but not in SPTA1, SLC4A1, or EPB42. Deleterious mutations including frameshift, nonsense, and splice site mutations were identified in 91%(21/23) and non-hotspot mutations were dispersed across multiple exons. Genotype-phenotype corre...



Outbreak of parvovirus B19 infection among anesthesiology and surgical fellows

Sun, 31 Jan 2016 00:00:00 +0100

Publication date: Available online 29 January 2016 Source:American Journal of Infection Control Author(s): Reynaldo Lara-Medrano, Michel Fernando Martínez-Reséndez, Elvira Garza-González, Ana Gabriela Medina-Torres, Adrián Camacho-Ortiz A human parvovirus B19 outbreak was detected in personnel assigned to a surgical area (anesthesiology fellows and an otorhinolaryngology fellow) in a university hospital. The attack rate between susceptible members was higher than previous reports. Diagnosis was determined by polymerase chain reaction for human parvovirus B19 in serum of 1 subject and immunoglobulin M/immunoglobulin G antibody titer in the remaining subjects. Medical personnel were put on leave of absence until resolution of symptoms and laboratory confirmation of health. No case...



Insights into epidemiology of human parvovirus B19 and detection of an unusual genotype 2 variant, Bulgaria, 2004 to 2013

Thu, 28 Jan 2016 00:00:00 +0100

The present study aimed to determine the role of human parvovirus ?19 (B19V) as an aetiological agent in measles and rubella negative fever/rash patients from Bulgaria between 2004 and 2013. A total of 1,266 sera from all over the country were tested for B19V IgM antibodies and all positives were further investigated by polymerase chain reaction (PCR). Overall, 280 sera (22%) were B19V IgM positive and 227 of these (81%) were also PCR positive. The highest number of IgM positives was found among five to nine year-old children (27%). Eight infected women gave birth to healthy children; one fetus was aborted with hydrops fetalis. Of the 55 genetic sequences obtained, 54 belonged to genotype 1a and one grouped as a genotype 2 outlier. Phylogenetic analysis of all available genotype 2 sequence...



Insights into epidemiology of human parvovirus B19 and detection of an unusual genotype 2 variant, Bulgaria, 2004 to 2013.

Thu, 28 Jan 2016 00:00:00 +0100

Authors: Ivanova SK, Mihneva ZG, Toshev AK, Kovaleva VP, Andonova LG, Muller CP, Hübschen JM Abstract The present study aimed to determine the role of human parvovirus В19 (B19V) as an aetiological agent in measles and rubella negative fever/rash patients from Bulgaria between 2004 and 2013. A total of 1,266 sera from all over the country were tested for B19V IgM antibodies and all positives were further investigated by polymerase chain reaction (PCR). Overall, 280 sera (22%) were B19V IgM positive and 227 of these (81%) were also PCR positive. The highest number of IgM positives was found among five to nine year-old children (27%). Eight infected women gave birth to healthy children; one fetus was aborted with hydrops fetalis. Of the 55 genetic sequences obtained, 54 belonged to...



Pseudo-erysipelas: A new atypical cutaneous manifestation of parvovirus B19 primary infection.

Sat, 23 Jan 2016 18:57:02 +0100

Authors: Kechaou I, Cherif E, Boukhris I, Azzabi S, Kaouech Z PMID: 26791960 [PubMed - as supplied by publisher] (Source: Medecine et Maladies Infectieuses)

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The prevalence of infectious agents in patients with systemic sclerosis.

Wed, 20 Jan 2016 05:26:03 +0100

CONCLUSION: SSc is associated with a higher rate of certain infections, which deserves further investigation in order to assess the role of infections in disease etiology/pathogenesis. PMID: 26775370 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)



Parvovirus B19 myocarditis in children: an observational study

Wed, 20 Jan 2016 00:00:00 +0100

Conclusions PVB19 can cause a devastating myocarditis in children. Children with fulminant myocarditis, ST segment changes or a short prodrome have the worst outcome. Transplantation may be considered, but is rarely required in the acute period if mechanical circulatory support is utilised. If the initial presentation is survived, recovery of the myocardium can occur even in those who had fulminant myocarditis. (Source: Archives of Disease in Childhood)



Identification of recombination in the NS1 and VPs genes of parvovirus B19

Wed, 13 Jan 2016 12:15:09 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)



Microfluidic cartridge with integrated array of amorphous silicon photosensors for chemiluminescence detection of viral DNA

Wed, 13 Jan 2016 00:00:00 +0100

Publication date: Available online 12 January 2016 Source:Sensing and Bio-Sensing Research Author(s): M. Zangheri, M. Mirasoli, A. Nascetti, D. Caputo, F. Bonvicini, G. Gallinella, G. de Cesare, A. Roda Portable and simple analytical devices based on microfluidics with chemiluminescence detection are particularly attractive for point-of-care applications, offering high detectability and specificity in a simple and miniaturized analytical format. Particularly relevant for infectious disease diagnosis is the ability to sensitively and specifically detect target nucleic acid sequences in biological fluids. To reach the goal of real-life applications for such devices, however, several technological challenges related to full device integration are still to be solved, one key aspect r...



Femoral Agminated Petechiae Associated with Acute Parvovirus B19 Infection

Tue, 12 Jan 2016 20:15:40 +0100

No abstract available (Source: The Pediatric Infectious Disease Journal)

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Steroid-responsive Status Epilepticus Caused by Human Parvovirus B19 Encephalitis

Tue, 12 Jan 2016 20:15:40 +0100

No abstract available (Source: The Pediatric Infectious Disease Journal)



Epidemiologic study of human parvovirus B19 infection in East China

Wed, 06 Jan 2016 00:00:00 +0100

Human parvovirus B19 (B19V) infection causes a number of diseases in humans, and, in some circumstances, can be life threatening. To understand the epidemiology of B19V infection in the greater metropolitan area of Hangzhou, East China, we performed surveys of IgM and IgG antibodies against B19V and quantification of B19V DNA, by using enzyme‐linked immunosorbent assay and quantitative PCR, respectively, in plasma samples from diverse groups. These groups included anemia patients, Mycoplasma pneumonia‐ and Treponema pallidum‐infected patients, HIV‐positive individuals, and healthy blood donor volunteers. Our results demonstrated a low level of B19V IgG antibody presence, ranging from 21.9% to 41.8% in all the groups tested, suggesting a low prevalence of B19V infection in the area....



Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios

Wed, 06 Jan 2016 00:00:00 +0100

ConclusionsInfectious disease screening does not seem beneficial in pregnancies with isolated polyhydramnios (Source: Prenatal Diagnosis)



Update of the human parvovirus B19 biology.

Tue, 05 Jan 2016 00:00:00 +0100

Authors: Servant-Delmas A, Morinet F Abstract Since its discovery, the human parvovirus B19 (B19V) has been associated with many clinical situations in addition to the prototype clinical manifestations, i.e. erythema infectiosum and erythroblastopenia crisis. The clinical significance of the viral B19V DNA persistence in sera after acute infection remains largely unknown. Such data may constitute a new clinical entity and is discussed in this manuscript. In 2002, despite the genetic diversity among B19V viruses has been reported to be very low, the description of markedly distinct sequences showed a new organization into three genotypes. The most recent common ancestor for B19V genotypes was estimated at early 1800s. B19V replication is enhanced by hypoxia and this might to explain...



Aplastic Crisis Secondary to Parvovirus B19 Infection as the First Manifestation of an Undiagnosed Hereditary Spherocytosis: Report of a Pediatric Series of Spanish Patients

Fri, 01 Jan 2016 06:00:00 +0100

No abstract available (Source: Journal of Pediatric Hematology Oncology)

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Severe anemia due to parvovirus B19 in a silver haired boy.

Fri, 01 Jan 2016 00:00:00 +0100

We report a 17-month-old boy with GS type 2 who presented with severe anemia. Bone marrow examination of the child suggested parvovirus B19 as the cause of severe anemia, which was later confirmed by DNA polymerase chain reaction. PMID: 26960654 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)



Neuroimaging in Aicardi-Goutieres syndrome: Biomarkers for a progressive encephalopathy

Mon, 28 Dec 2015 00:00:00 +0100

In 1984, 2 pediatric neurologists, Jean Aicardi and Françoise Goutières, published their seminal case report of 8 patients (from 5 families) with a devastating neonatal encephalopathy characterized by striking cerebral calcifications, white matter hypodensities, visualized on CT, accompanied by a persistent CSF lymphocytosis.1 Notably, the neuroradiologic findings suggested a perinatal toxoplasmosis, other (syphilis, varicella-zoster, parvovirus b19), rubella, cytomegalovirus, and herpes (TORCH) infection, and these patients often have an elevation of interferon-α in the CSF.2,3 Three decades of highly productive clinical and scientific investigation of Aicardi-Goutières syndrome (AGS) has led to the discovery of 7 causative genes and the realization that mutatio...



An epidemiologic study of human parvovirus B19 infection in East China

Thu, 24 Dec 2015 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)



[Collapsing variant of focal segmental glomerulosclerosis by parvovirus B19: case report].

Mon, 21 Dec 2015 03:45:46 +0100

CONCLUSION: There is demonstrated the temporal association of PVB19 viremia and collapsing FSGS, due primary infection or viral reactivation. The association of collapsing FSGS and PVB19 is described in the literature, demonstrating virus presence in kidney tissue, but the real relationship of virus in the pathogenesis of this glomerulopathy remains unclear. PMID: 25923759 [PubMed - in process] (Source: Jornal Brasileiro de Nefrologia)



Focal seizure associated with human parvovirus B19 infection in a non-encephalopathic child.

Fri, 18 Dec 2015 00:00:00 +0100

CONCLUSIONS: We report an extremely rare presentation of non-febrile seizure from acute parvovirus infection in a child without encephalopathy who had an excellent recovery. Timely diagnosis can provide counselling regarding future seizure recurrence risk, curtail expenditure from expensive diagnostic work up and provide additional recommendations about potential risks to a pregnant caregiver. PMID: 26684306 [PubMed - as supplied by publisher] (Source: World Journal of Pediatrics : WJP)

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Clinical features of 10 fetuses with prenatally diagnosed parvovirus b19 infection and fetal hydrops.

Tue, 15 Dec 2015 18:12:02 +0100

CONCLUSIONS: The survival rate for parvovirus infection associated with fetal hydrops was 60%. MCA-PSV and IUT are useful for the management and treatment of fetal anemia due to parvovirus infection. PMID: 25313841 [PubMed - indexed for MEDLINE] (Source: Fetal and Pediatric Pathology)



Petechial rash associated with Parvovirus B19 in children: case report and literature review.

Sat, 12 Dec 2015 19:19:29 +0100

We describe an unusual paediatric case of B19V associated with generalized petechial eruption, and a review of the recent literature. PMID: 25269970 [PubMed - in process] (Source: Infezioni in Medicina)



Atypical exanthems associated with parvovirus B19 infection: similarities and differences between adults and children.

Sat, 12 Dec 2015 19:19:29 +0100

Authors: Drago F, Ciccarese G, Javor S, Cozzani E, Parodi A Abstract No abstract available. PMID: 26397302 [PubMed - as supplied by publisher] (Source: Infezioni in Medicina)



Evaluation of a standardised real-time PCR based DNA-detection method (Realstar®) in whole blood for the diagnosis of primary human cytomegalovirus (CMV) infections in immunocompetent patients

Thu, 10 Dec 2015 00:00:00 +0100

In this study we evaluated the performance of a commercially available and standardised CMV PCR assay in whole blood for the diagnosis of a primary infection in immunocompetent adults. Moreover, the kinetics of viral DNA was evaluated in order to provide a time frame in which viral DNA could be detected during an acute primary infection. Whole blood samples were collected from 66 patients with an acute CMV infection, 65 patients with an acute Epstein-Barr virus infection, 27 patients with various other acute infections (parvovirus B19, HIV, Toxoplasma gondii), 20 patients with past CMV infections (>1 year) and 20 apparently healthy persons. For CMV DNA detection and quantification a commercially available real-time PCR was applied (RealStar®, altona Diagnostics). The clinical sensitiv...



Complexity in interpreting partial viral sequence data as supportive evidence for possible transfusion transmitted Parvovirus B19 infection

Tue, 08 Dec 2015 00:00:00 +0100

(Source: Vox Sanguinis)

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BK virus-related thrombotic microangiopathy in a kidney transplant recipient

Wed, 02 Dec 2015 00:00:00 +0100

In this report, we present our experiences of successful treatment of a renal transplant case of TMA due to BK virus, not a frequent cause of TMA. The clinical picture of TMA caused by endothelial damage through cytopathic effects of viral antigens was evaluated in the light of the relevant literature. (Source: Indian Journal of Transplantation)



Viral Skin Diseases.

Mon, 30 Nov 2015 02:50:19 +0100

Authors: Ramdass P, Mullick S, Farber HF Abstract In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human papilloma virus, hand, foot, and mouth disease, molluscum contagiosum, and Gianotti-Crosti syndrome. PMID: 26612372 [PubMed - in process...



The role of infection in miscarriage

Mon, 30 Nov 2015 00:00:00 +0100

CONCLUSIONS Further research is required to clarify whether certain infections do increase miscarriage risk and whether screening of newly pregnant women for treatable infections would improve reproductive outcomes. (Source: Human Reproduction Update)



Viral Skin Diseases

Wed, 25 Nov 2015 03:18:43 +0100

In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human papilloma virus, hand, foot, and mouth disease, molluscum contagiosum, and Gianotti-Crosti syndrome. (Source: Primary Care: Clinics in Office Practice)



Human parvovirus B19 and low hemoglobin levels in pregnant Sudanese women

Tue, 24 Nov 2015 00:00:00 +0100

Conclusion B19V IgG seropositivity was 49.7% among the study group. These patients exhibited lower hemoglobin levels and a significant association was found between B19V IgG seropositivity and hemoglobin level. (Source: International Journal of Gynecology and Obstetrics)

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[Parvovirus B19 seroprevalence in a group of schizophrenic patients.]

Fri, 20 Nov 2015 15:28:39 +0100

CONCLUSIONS: In our study, prevalence of IgG antibodies to PB19 was significantly higher in schizophrenic patients than in controls. This finding supports the hypothesis of the involvement of PB19 in schizophrenia. Further studies including both virological and immunological aspects are needed to better clarify the etiopathogenic mechanisms of schizophrenia which would challenge the management of this disease. PMID: 25529557 [PubMed - as supplied by publisher] (Source: L Encephale)



Time-series analysis comparing the prevalence of antibodies against nine viral species found in umbilical cord blood in Japan.

Fri, 13 Nov 2015 00:00:00 +0100

In this study, we investigated the prevalence of antibodies against nine viral species found in umbilical cord blood obtained from 561 neonates in 2013. Serum IgG antibodies against the following viruses were measured: herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), measles virus (MV), rubella virus (RV), mumps virus (MuV), and human parvovirus B19 (HPV B19). A survey questionnaire for past history and maternal immunization status was simultaneously administered for the vaccine-preventable diseases of varicella, measles, rubella, and mumps. The results were compared with previous data collected in 2001-2002 from 378 umbilical cord blood samples. Virus seroprevalence data were as follows: HSV, 54%; VZV, ...



Prevalence and genotypic characterization of Human Parvovirus B19 in children with measles‐ and rubella‐like illness in Iran

Fri, 13 Nov 2015 00:00:00 +0100

Human Parvovirus B19 (B19V) is a prototype of the Erythroparvovirus genus in Parvoviridae family. B19V infections are often associated with fever and rash, and can be mistakenly reported as measles or rubella. Differential diagnosis of B19V illness is necessary for case management and also for public health control activities, particularly in outbreak situations in which measles or rubella is suspected. To investigate the causative role of B19V infection in children with measles‐ and rubella‐like illness, a total of 583 sera from children with exanthema were tested for presence of B19V by determining anti‐B19V IgG and IgM antibodies by ELISA as well as B19V DNA detection by nested PCR. DNA positive samples were assessed further for determination of viral load and sequence analysis by...



Prevalence and genotype characterization of Human Parvovirus B19 in children with measles‐ and rubella‐like illness in Iran

Thu, 05 Nov 2015 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)

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Confirmation of etiology in fetal hydrops by sonographic evaluation of fluid allocation patterns

Thu, 05 Nov 2015 00:00:00 +0100

Conclusion Due to the allocation patterns of fluid filled sites in fetuses with hydrops fetalis the spectrum of possible etiologies may be narrowed already during initial ultrasound scan. It can contribute substantially to diagnostic accuracy as well as to parental counseling. This knowledge may also help to omit delay in diagnostic routines. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)



High Frequency of Detection by PCR of Viral Nucleic Acid in The Blood of Infants Presenting with Clinical Myocarditis

Mon, 26 Oct 2015 00:00:00 +0100

Abstract Specific viruses are associated with pediatric myocarditis, but the prevalence of viral DNAemia detected by blood polymerase chain reaction (PCR) is unknown. We evaluated the prevalence of known cardiotropic viruses (enterovirus, adenovirus, human herpesvirus 6, and parvovirus B19) in children with clinical myocarditis (n = 21). Results were compared to pediatric controls with similar viral PCR testing. The majority of positive PCR (89 %) was noted in children ≤12 months of age at diagnosis compared to older children. Infant myocarditis patients (8/10) had increased the prevalence of PCR positivity compared to infant pediatric controls (4/114) (p < 0.0001). Other than age, patient characteristics at diagnosis were similar between PCR-positive and PCR-negative ...



Prevalence and Viral Load of Human Parvovirus B19 (B19V) Among Blood Donors in South-East Brazil

Mon, 19 Oct 2015 00:00:00 +0100

The objective of this study was to examine the B19V DNA prevalence and viral load in first-time volunteer blood donors. Blood samples were collected from 91 primary blood donors at the Regional Blood Center of Ribeirão Preto, Southeast Brazil. Viral detection and quantitation was performed by an in-house TaqMan® real-time PCR with high sensitivity. B19V DNA was detected in one male blood donor (1.0 %) and was characterized by a very low viral load (537.36 copies/mL). Our studies demonstrate that B19V DNA at low titer may be present in apparently healthy individuals. Sensitive molecular diagnostic tools can be applied for the screening of fresh blood derived products in order to prevent transfusion-transmitted B19V infection. (Source: Indian Journal of Hematology and Blood Transfusion)



Recurrent pure red cell aplasia in a hepatorenal transplant recipient with chronic parvovirus B19 infection

Mon, 12 Oct 2015 00:00:00 +0100

(Source: British Journal of Haematology)



Giant cell hepatitis with Coombs-positive hemolytic anemia: Possible association with Kabuki syndrome?

Thu, 08 Oct 2015 00:00:00 +0100

A 7-month-old infant presented with acute hemolytic anemia characterized by severe pallor, hepatosplenomegaly, hemoglobin 4.6g/dl, total bilirubin 4.02mg/dl (unconjugated 2.29), positive direct Coombs’ test. The child received erythrocytes transfusion and therapy with high-dose of steroids, first intravenously and then orally. Laboratory showed also: AST 1088 U/l, ALT 1176 U/l, GGT 155 U/l, conjugated bilirubin 1.83mg/dl, LDH 2429 U/l, INR 1. Serological tests for HAV, HBV, HCV, EBV, CMV, HSV, Parvovirus B19, HIV were negative. (Source: Digestive and Liver Disease)

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Parvovirus B19–Associated Microvesicular Eruption

Thu, 08 Oct 2015 00:00:00 +0100

We report on a 3‐year‐old girl with a microvesicular generalized rash in whom primary infection by parvovirus B19 was demonstrated by seroconversion. To our knowledge, this is the first instance of an eruption arising from parvovirus B19 with this peculiar clinical pattern. (Source: Pediatric Dermatology)



Prevalence of human parvovirus B19 in Chinese plasma pools for manufacturing plasma derivatives

Tue, 06 Oct 2015 00:00:00 +0100

Conclusions: The high level of B19V in plasma pools could present a great risk in plasma derivatives. Therefore, the implementation of B19V NAT (Nucleic Acid Testing) assays capable of detecting all B19V genotypes and discard donations with high titer B19V DNA for Chinese blood products manufacturers seems to be necessary. (Source: Virology Journal)



Parvovirus B19-induced acute bilateral carpal tunnel syndrome in twin girls.

Fri, 02 Oct 2015 05:46:02 +0100

We describe 2 cases of 6-year-old twin girls presenting with acute carpal tunnel syndrome (CTS) associated with human parvovirus B19 (HPV-B19) infection, as evidenced by serological data and detection of HPV-B19 DNA in blood with use of polymerase chain reaction (PCR). To our knowledge, this is the first time that HPV-B19 infection has been suggested as the causal agent of simultaneous acute bilateral CTS in twins, thus presenting the possibility that similar immunologic responses can be observed in twins during viral infections. PMID: 26422355 [PubMed - in process] (Source: Acta Orthopaedica et Traumatologica Turcica)



Acute parvovirus B19 infection detected in bone marrow biopsy

Thu, 24 Sep 2015 00:00:00 +0100

(Source: Blood)



Human Parvovirus B19 and autoimmune diseases. Review of the literature and pathophysiological hypotheses

Thu, 24 Sep 2015 00:00:00 +0100

Autoimmunity results from immunization of an organism against its own constituents, leading to the production of autoantibodies and/or autoreactive cytotoxic cells. B lymphocytes and/or other cells responsible for autoimmunity are present in all healthy subjects, but are maintained inactive by a number of regulatory and control mechanisms. When this balance is disrupted, all subjects are able to develop an autoimmune disease. Three conditions are required to disrupt this balance, allowing the development of an autoimmune disease: multiple triggering factors (aetiology), persistence of their effects (pathophysiology), and induction of lesions (pathogenesis) [1]. (Source: Journal of Clinical Virology)

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Unexpected Anemia and Reticulocytopenia in an Adolescent With Sickle Cell Anemia Receiving Chronic Transfusion Therapy

Fri, 18 Sep 2015 20:04:50 +0100

In a patient with sickle cell disease receiving chronic transfusion, exacerbation of anemia with reticulocytopenia must prompt consideration of a delayed hemolytic transfusion reaction with hyperhemolysis, as further transfusion may worsen this condition; definitive diagnosis is sometimes difficult. Anemia evolving during parvovirus B19-induced erythroid hypoplasia (transient aplastic crisis) should be attenuated in chronic transfusion patients due to superior survival of transfused over endogenous red blood cells. A 16-year-old with sickle cell disease receiving chronic transfusion of modified intensity (goal to maintain hemoglobin S (Source: Journal of Pediatric Hematology Oncology)



PRDM1 Expression via Human Parvovirus B19 Infection Plays a Role In the Pathogenesis of Hashimoto’s Thyroiditis

Thu, 10 Sep 2015 00:00:00 +0100

Ectopic lymphoid follicle infiltration is a key event in Hashimoto's thyroiditis (HT). Positive regulatory domain zinc finger protein 1 (PRDM1), which induced by antigen stimulation, can regulate all lymphocyte lineages. Several groups independently demonstrated that human parvovirus B19 (PVB19) is closely associated with HT. Hence, we determined whether PRDM1 expressed in HT thyroid tissue and whether there is any correlation between PRDM1 expression and PVB19 in the pathogenesis of HT. We detected PRDM1 expression in HT (n=86), normal thyroid tissues (n=30), and non-toxic nodular goiter (n=20) samples using immunohistochemistry. (Source: Human Pathology)



PRDM1 expression via human parvovirus B19 infection plays a role in the pathogenesis of Hashimoto thyroiditis

Thu, 10 Sep 2015 00:00:00 +0100

Ectopic lymphoid follicle infiltration is a key event in Hashimoto thyroiditis (HT). Positive regulatory domain zinc finger protein 1 (PRDM1), which is induced by antigen stimulation, can regulate all lymphocyte lineages. Several groups independently demonstrated that human parvovirus B19 (PVB19) is closely associated with HT. Hence, we determined whether PRDM1 is expressed in HT thyroid tissue and whether there is any correlation between PRDM1 expression and PVB19 in the pathogenesis of HT. We detected PRDM1 expression in HT (n = 86), normal thyroid tissue (n = 30), and nontoxic nodular goiter (n = 20) samples using immunohistochemistry. (Source: Human Pathology)



Validation of new real-time polymerase chain reaction assays for detection of hepatitis A virus RNA and parvovirus B19 DNA.

Wed, 09 Sep 2015 00:00:00 +0100

CONCLUSION: The dual-target B19V polymerase chain reaction (PCR) showed good accuracy (<0.1 log IU/mL) at the crucial concentration of 10 IU/µL for the NS1 and the VP2 region of the B19V genome and detected all known genotypes with similar sensitivity for each genotype. In addition, the dual target format reduces the chance that molecular variants of B19V are wrongly quantified. The HAV RNA assay showed high sensitivity for Genotypes I to III. Both new PCR assays have been successfully introduced for plasma screening in test pools of 480 or 96 donations. PMID: 26354230 [PubMed - as supplied by publisher] (Source: Transfusion)



Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy

Thu, 03 Sep 2015 00:00:00 +0100

Human parvovirus B19 (B19V) is a common pathogen in microvascular disease and cardiomyopathy, owing to infection of endothelial cells. B19V replication, however, is almost restricted to erythroid progenitor cells (ErPCs). Endothelial regeneration attributable to bone marrow–derived circulating angiogenic cells (CACs) is a prerequisite for organ function. Because of many similarities of ErPCs and CACs, we hypothesized that B19V is a perpetrator of impaired endogenous endothelial regeneration. B19V DNA and messenger RNA from endomyocardial biopsy specimens, bone marrow specimens, and circulating progenitor cells were quantified by polymerase chain reaction analysis. The highest B19V DNA concentrations were found in CD34+KDR+ cells from 17 patients with chronic B19V-associated cardiomyo...

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Parvovirus B19 1A complete genome from a fatal case in Brazil.

Tue, 01 Sep 2015 00:00:00 +0100

Authors: Conteville LC, Zanella L, Marín MA, Filippis AM, Nogueira RM, Vicente AC, Mendonça MC Abstract Parvovirus B19 (B19V) infects individuals worldwide and is associated with an ample range of pathologies and clinical manifestations. B19V is classified into three distinct genotypes, all identified in Brazil. Here, we report a complete sequence of a B19V genotype 1A that was obtained by high-throughput metagenomic sequencing. This genome provides information that will contribute to the studies on B19V epidemiology and evolution. PMID: 26517666 [PubMed - in process] (Source: Memorias do Instituto Oswaldo Cruz)



Non HCV-related infectious cryoglobulinemia vasculitis: Results from the French nationwide CryoVas survey and systematic review of the literature.

Thu, 27 Aug 2015 00:00:00 +0100

We describe here the presentation, therapeutic management and outcome of 18 patients with non-HCV infectious CryoVas and 27 additional patients identified form a systematic review of the literature. We included 18 patients, mean age 57.9±13.5 years. Infectious causes were viral infections in 8 patients [hepatitis B virus (HBV) in 4, and cytomegalovirus, Epstein Barr virus, parvovirus B19 and human immunodeficiency virus in one case each], pyogenic bacterial infection in 6 patients, parasitic infection in 2 patients, and leprosy and candidiasis in one case each. Baseline manifestations were purpura (78%), glomerulonephritis (28%), arthralgia (28%), peripheral neuropathy (22%), skin necrosis (22%), cutaneous ulcers (17%), and myalgia (11%). Cryoglobulinemia was type II in 2/3 of cases. Most...



Serum level of C‐reactive protein is not a parameter to determine the difference between viral and atypical bacterial infections

Wed, 19 Aug 2015 00:00:00 +0100

This study suggests that CRP values are useful to define viral and atypical bacterial infections compared with normal values, but, it is not useful to define type of infection. J. Med. Virol. © 2015 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)



Pericardial Effusion and Adenosine Deaminase False Positivity Due to Parvovirus B19

Fri, 14 Aug 2015 18:11:17 +0100

This case is presented to highlight that one of the causes for massive exudative pericardial effusion in a child may be parvovirus B19, and adenosine deaminase can be falsely positive in such patients. (Source: The Pediatric Infectious Disease Journal)



Serum level of C ‐ reactive protein is not a parameter to determine the difference between viral and atypical bacterial infections

Tue, 04 Aug 2015 00:00:00 +0100

This study suggests that CRP values are useful to define viral and atypical bacterial infections compared with normal values, but, it is not useful to define type of infection. This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)

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Common Skin Rashes in Children.

Sat, 01 Aug 2015 00:00:00 +0100

Authors: Allmon A, Deane K, Martin KL Abstract Because childhood rashes may be difficult to differentiate by appearance alone, it is important to consider the entire clinical presentation to help make the appropriate diagnosis. Considerations include the appearance and location of the rash; the clinical course; and associated symptoms, such as pruritus or fever. A fever is likely to occur with roseola, erythema infectiosum (fifth disease), and scarlet fever. Pruritus sometimes occurs with atopic dermatitis, pityriasis rosea, erythema infectiosum, molluscum contagiosum, and tinea infection. The key feature of roseola is a rash presenting after resolution of a high fever, whereas the distinguishing features in pityriasis rosea are a herald patch and a bilateral and symmetric rash in ...



The prevalence of hepatitis A virus and parvovirus B19 in source‐plasma donors and whole blood donors in China

Sat, 01 Aug 2015 00:00:00 +0100

ConclusionsThe transfer of RP to producing plasma derivatives will not increase the risk of transmission of HAV and B19 through plasma products. (Source: Transfusion Medicine)



A flow-FISH assay for the quantitative analysis of parvovirus B19 infected cells.

Wed, 29 Jul 2015 00:00:00 +0100

Authors: Manaresi E, Bua G, Bonvicini F, Gallinella G Abstract Human parvovirus B19 (B19V) replication is a process highly dependent on the cellular environment, therefore methodologies allowing for analysis at single cell level could represent effective tools to understand cell-to cell differences in the replication process and to investigate cell-virus interactions. Fluorescence in situ hybridization (FISH) can be combined with flow cytometry (flow-FISH) to enable the detection of target nucleic acid sequences in thousands of individual cells in a short amount of time. In the present study, a flow-FISH assay based on the use of a digoxigenin-labeled genomic probe has been developed to discriminate B19V infected cells following in vitro infection of UT7/EpoS1 cell line and EPCs (e...



Remitting seronegative symmetrical synovitis with pitting edema associated with parvovirus B19 infection: two new cases and review of the comorbidities

Fri, 03 Jul 2015 00:00:00 +0100

ConclusionsWe want to underline the importance for patients with RS3PE to be seen by dermatologists who should become familiar with this syndrome and remark that Parvovirus B19 infection may be a potential cause of RS3PE. (Source: International Journal of Dermatology)



Predictors of outcome in patients with parvovirus B19 positive endomyocardial biopsy

Thu, 02 Jul 2015 00:00:00 +0100

Conclusion The viral load of PVB19 genomes in the myocardium is not related to the long-term outcome. Furthermore, this study suggests a growing role of imaging for risk stratification in non-ischemic myocardial disease. (Source: Clinical Research in Cardiology)

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Real time PCR reconfirmed three novel clinical associations of parvovirus B19: Non-occlusive bowel gangrene, amegakaryocytic thrombocytopenia & myositis.

Wed, 01 Jul 2015 00:00:00 +0100

Authors: Kishore J PMID: 26261172 [PubMed - in process] (Source: Indian J Med Res)



Niedokrwistość Blackfana i Diamonda z towarzyszącą replikacją parwowirusa B19. Opis przypadku

Fri, 26 Jun 2015 00:00:00 +0100

Publication date: May–June 2015 Source:Pediatria Polska, Volume 90, Issue 3 Author(s): Joanna Krukowska-Jaros , Ewa Niedzielska , Marek Ussowicz , Hanna Gazda , Stanisław Zajączek , Ewa Gorczyńska Anaemia is one of the most common haematological problems in infants. Diagnosis of anaemia is based on anamnesis, the results of physical examination and basic laboratory tests. During infancy, one of the main causes of anaemia is iron deficiency but in some cases haematopoiesis can be hampered by myeloproliferative disease, congenital or acquired bone marrow failure, too. This paper presents a case report of a 6-month-old girl with typical dysmorphic features. Initially the girl was diagnosed with iron-deficiency anaemia, due to suspected chronic gastrointestinal bleeding, as a result of ...



Diffuse Hepatic FDG Activity From Nonmalignant Etiologies

Tue, 09 Jun 2015 02:50:20 +0100

We describe here cases of diffuse, uniformly increased 18F-FDG activity due to nonmalignant illnesses in 2 patients: one had parvovirus B19 infection, whereas the other had porphyria, a heme synthesis disorder. (Source: Clinical Nuclear Medicine)



Influenza A and Parvovirus B19 Seropositivity Rates in Gabonese Infants.

Mon, 08 Jun 2015 00:00:00 +0100

Authors: Gabor JJ, Schwarz NG, Esen M, Kremsner PG, Grobusch MP Abstract Clinical and epidemiological data from Central Africa on influenza A and parvovirus B19 infections are limited. We analyzed 162 blood samples of infants 3, 9, 15, and 30 months of age for IgG antibodies against both pathogens. Antibody responses were 0, 3.7%, 12.3%, and 20.4% against influenza A; and 1.2%, 2.5%, 3.1%, and 9.3% against parvovirus B19, respectively. Seropositivity rates were 89.5 (95% confidence interval [CI]: 59-120.1) and 38.2 (95% CI: 18.9-57.6)/1,000 person-years at risk for influenza A and parvovirus B19, respectively. Our data add to the understanding of the epidemiology of both conditions. PMID: 26055747 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Med...



Look‐back study on recipients of Parvovirus B19 (B19V) DNA‐positive blood components

Fri, 05 Jun 2015 00:00:00 +0100

ConclusionsTT‐B19V infections through blood components with low (<104 IU/ml plasma) B19V DNA concentrations did not occur in our study. One of the TT‐B19V infections occurred from RBC with intermediate B19V DNA concentration despite the presence of potential neutralizing antibodies in the donor, but its clinical significance was low. (Source: Vox Sanguinis)

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Complete recovery of a patient with cardiogenic shock due to parvovirus B19 fulminant myocarditis after treatment with extracorporeal membrane oxygenation and intravenous immunoglobulin.

Wed, 03 Jun 2015 16:15:43 +0100

Authors: Drwiła R, Rubiś P, Kapelak B, Rudnicka-Sosin L, Pankuweit S, Gackowski A PMID: 25666442 [PubMed - in process] (Source: Polskie Archiwum Medycyny Wewnetrznej)



Neonatal outcome after fetal anemia managed by intrauterine transfusion

Tue, 02 Jun 2015 00:00:00 +0100

Conclusion: Contemporary management of Rhesus disease is associated with encouraging neonatal outcomes. In case of Parvovirus infection, no specific management is necessary at. But, in all cases of fetal anemia, children should be followed up with particular attention to neurologic development. What is Known: • In-utero transfusion is now well under control and improves the survival of fetuses monitored for fetal anemia. • Limited studies are available on the effect of IUT on postnatal outcome in infants with a history of fetal anemia. What is New: ...



[Parvovirus B19 infection and pregnancy].

Mon, 01 Jun 2015 00:00:00 +0100

Authors: Subtil D, Garabedian C, Chauvet A Abstract "Small virus" contagious during spring, parvovirus B19 is responsible for fifth disease of children. The prevalence of infection is very high before 10years old and children are especially responsible for transmission to pregnant women. Approximately 50% of women old enough to procreate have stigmas serologic of old infection. Acquired immunity is long hasting and solid. During pregnancy, this virus is responsible for abortion, fetal anemia. Severe anemia can cause hydrops fetalis or fetal mortality in utero or neurologic damage. We are going to start again point by point of the contage has the care the situations with which the doctor can be confronted during the pregnancy. PMID: 26044725 [PubMed - as supplied by publisher] (...



Array-in-well serodiagnostic assay utilizing upconverting phosphor label technology.

Thu, 28 May 2015 00:00:00 +0100

In conclusion, the array-in-well with upconverting phosphor reporter technology was able to detect antiviral antibodies in human sera, and represents an efficient serodiagnostic concept that is a promising new tool for multiplex serology. PMID: 26028427 [PubMed - as supplied by publisher] (Source: Journal of Virological Methods)



Practice Bulletin No. 151: Cytomegalovirus, Parvovirus B19, Varicella Zoster, and Toxoplasmosis in Pregnancy.

Sun, 24 May 2015 15:34:09 +0100

Authors: PMID: 26000539 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)

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Parvovirus B19 diagnosed by bone marrow biopsy

Thu, 21 May 2015 00:00:00 +0100

(Source: Blood)



Detection of cytomegalovirus, human parvovirus B19, and herpes simplex virus‐1/2 in women with first‐trimester spontaneous abortions

Thu, 14 May 2015 00:00:00 +0100

The relationship between viral infections and first‐trimester spontaneous abortions is not well‐understood. The study aim was to investigate the prevalence of cytomegalovirus (CMV), human parvovirus B19 (B19V), and herpes simplex virus‐1/2 (HSV‐1/2) infection by molecular and serological techniques in women experiencing spontaneous miscarriage in the first trimester of pregnancy. Plasma samples were examined for CMV, B19V, and HSV‐1/2 DNA using real‐time quantitative polymerase chain reaction (Real‐time qPCR), and for specific IgG antibodies against B19V, CMV, and HSV‐1/2 using serological assays. The abortion group consisted of women (n = 1,716) with a history of two or more first‐trimester spontaneous abortions. Women younger than 30 years possess higher portion to ...



Parvovirus B19 infection as a cause of acute myositis in an adult

Wed, 13 May 2015 05:19:39 +0100

A infecção pelo Parvovírus B19 costuma ser assintomática, mas as expressões clínicas podem incluir crise aplástica transitória, eritema infeccioso, hidropisia fetal não imune e aplasia crônica da série vermelha. Esse vírus também se associa à artrite reumatoide e a outras doenças autoimunes do tecido conjuntivo; entretanto, não conseguimos identificar na literatura nenhum caso de miosite aguda em adulto desenvolvida depois de infecção pelo Parvovírus B19. Por essa razão, gostaríamos de apresentar um caso raro de miosite aguda desenvolvida depois de infecção pelo Parvovírus B19. Nos pacientes que apresentam sintomas de febre, rash nas pernas e miosite, devem ser consideradas as infecções virais, como a causada pelo Parvovírus B19.Parvovirus B19 infection is often ...



Atypical exanthems associated with Parvovirus B19 (B19V) infection in children and adults

Tue, 12 May 2015 00:00:00 +0100

In conclusion this study reveals that atypical exanthems related to B19V infection are possible both in children and in adults, with a similar prevalence. J. Med. Virol. © 2015 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)



Acute Parvovirus B19 Infection in Adults

Fri, 08 May 2015 00:00:00 +0100

Publication date: May 2015 Source:Actas Dermo-Sifiliográficas (English Edition), Volume 106, Issue 4 Author(s): S. Sai Tin , V. Wiwanitkit (Source: Actas Dermo-Sifiliograficas)

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Large‐scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation

Wed, 06 May 2015 00:00:00 +0100

Viral reactivations following hematopoietic stem cell transplantation are thought to result from the breakdown of both cell‐mediated and humoral immunity. As a result, many viruses could be reactivated individually or simultaneously. Using a multiplex polymerase chain reaction (PCR), we prospectively examined many kinds of viral DNAs at a time in 105 patients who underwent allogeneic hematopoietic stem cell transplantation. In total, 591 whole blood samples were collected weekly from pre‐ to 42 days post‐transplantation and the following 13 viruses were tested; herpes simplex virus 1 (HSV‐1), HSV‐2, varicella‐zoster virus (VZV), Epstein–Barr virus (EBV), cytomegalovirus (CMV), human herpes virus 6 (HHV‐6), HHV‐7, HHV‐8, adenovirus, BK virus (BKV), JC virus (JCV), parvov...



A review of blood diseases and cytopenias associated with human parvovirus B19 infection

Fri, 01 May 2015 00:00:00 +0100

SUMMARY Parvovirus B19 is a single‐stranded DNA virus which preferentially targets the erythroblast resulting in red cell aplasia, which is temporary in immunocompetent persons. Since the discovery of B19 virus in 1975, a wide variety of blood diseases and cytopenias affecting several blood cell lineages have been documented during or following B19 infection. These include cytopenias affecting the erythroid, megakaryoblastoid, myeloid and lymphoid lineages, as well as a variety of bicytopenias, pancytopenia, bone marrow necrosis / fat embolism syndrome, myelodysplastic syndrome, leucoerythroblastopenia, and hemophagocytic lymphohistiocytosis. B19 infection may also complicate and precede the course of acute leukemia, the significance of which remains to be determined. This review describ...



Spectrum of adult Parvovirus B19 infection according to the underlying predisposing condition and proposals for clinical practice

Tue, 28 Apr 2015 00:00:00 +0100

Summary The virological diagnosis of Parvovirus B19 (PvB19) infection is currently based on sero‐diagnosis, molecular methods or both, yet without clear recommendations. We retrospectively identified patients with polymerase chain reaction‐positive PvB19 and/or positive serological assay between 2007 and 2013. Eighty‐two adults with at least one diagnostic criterion of recent PvB19 infection (IgM antibodies, viral DNA in blood and/or in marrow) were included and classified into three homogeneous groups: 30 patients had no underlying predisposing condition, 25 a hereditary haemolytic anaemia, 27 an underlying immunodeficiency. The classical PvB19‐related manifestations were less frequent in immunocompromised than in immunocompetent patients (arthromyalgia: 5 vs. 14; erythema: 4 vs....



Characterization of Markers of the Progression of Human Parvovirus B19 Infection in Virus DNA-Positive Plasma Samples

Fri, 24 Apr 2015 12:09:31 +0100

Conclusion: This study of B19V-DNA load and levels of neopterin, IgM, and IgG allows for reliable characterization and distribution into the different stages of B19V infection.Transfus Med Hemother (Source: Transfusion Medicine and Hemotherapy)



Congenital Human Parvovirus B19 Infection With Persistent Viremia

Tue, 07 Apr 2015 00:00:00 +0100

(Source: Clinical Pediatrics)

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Response to “Acute Parvovirus B19 Infection in Adults: A Retrospective Study of 49 Cases”

Tue, 07 Apr 2015 00:00:00 +0100

Publication date: Available online 6 April 2015 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): A.I. Rodríguez Bandera , M. Mayor Arenal , K. Vorlicka , E. Ruiz Bravo-Burguilllos , D. Montero Vega , C. Vidaurrázaga Díaz-Arcaya (Source: Actas Dermo-Sifiliograficas)



Non-immune Hydrops fetalis due to Parvovirus B19 Infection in 2 Extremely Preterm Infants: Perinatal Management and Long-term Neurodevelopmental Outcome.

Wed, 01 Apr 2015 00:00:00 +0100

We report on the long-term outcomes of 2 extremely preterm children after non-immune hydrops fetalis due to intrauterine B19V Infection. PMID: 25830498 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Geburtshilfe und Neonatologie)



A new quantitative PCR for human parvovirus B19 genotypes.

Tue, 17 Mar 2015 00:00:00 +0100

In this study, we present a new PCR assay for detection and quantification as well as for differentiation of all three B19V genotypes. A new B19V qPCR was designed to target a 154-bp region of the NS1 area. Serum, plasma and solid tissue samples were suitable for testing in the assay. The WHO International Reference Panel for Parvovirus B19 Genotypes was utilized to validate the assay for detection of different genotypes of B19V in clinical material. Each panel member yielded, by the new qPCR, a quantity similar to the one reported by National Institute for Biological Standards and Control (NIBSC). The qPCR was specific for B19V and amplified and quantified all three genotypes with detection sensitivities of ≤10 copies/reaction. The differentiation of B19V genotypes was performed by Sang...



Acute myocarditis associated with parvovirus B19 infection in a child

Sat, 14 Mar 2015 00:00:00 +0100

We report here the case of a 3-year-old girl who developed myocarditis secondary to parvovirus B19 virus. Diagnosis of PVB19 infection was made with serological tests. The outcome was favorable after immunoglobulins. (Source: Pediatric Infectious Disease)



Frequency and genotype of human parvovirus B19 among Iranian patients infected with HIV

Fri, 13 Mar 2015 00:00:00 +0100

The human parvovirus B19 (B19) usually causes a subclinical infection in immunocompetent individuals. Whereas immunocompromised individuals such as patients infected with HIV are at risk of persistent anemia due to B19 infection. Only few studies have been carried out on distribution and molecular epidemiology of B19 in Iran. We aimed to determine the frequency and genotype of B19 among Iranian patients infected with HIV. We conducted a survey on 99 HIV patients and 64 healthy controls. IgG and IgM antibodies against B19 were detected by ELISA and B19 DNA was assessed by nested PCR. PCR products were subjected to direct sequencing and classified after phylogenetic analysis. The prevalence of B19 immunoglobulin was 11.1% for IgG and 1% for IgM. B19 DNA was detected in 13.1% of cases. The pr...

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Parvovirus B19 infection presenting with severe erythroid aplastic crisis during pregnancy in a woman with autoimmune hemolytic anemia and alpha-thalassemia trait: a case report

Thu, 12 Mar 2015 00:00:00 +0100

Conclusions Parvovirus B19 virus infection should be considered when a sudden exacerbation of anemia occurs in a patient with hemolytic disease, and the possible fetal complications caused by maternal B19 virus infection during pregnancy should not be ignored. Close monitoring and adequate management can keep both mother and fetus safe. (Source: Journal of Medical Case Reports)



Use of exploratory factor analysis to ascertain the correlation between the activities of rheumatoid arthritis and infection by human parvovirus B19.

Sun, 08 Mar 2015 22:24:03 +0100

CONCLUSIONS: Using EFA and DAS28, a correlation between the clinical activity of RA and B19 infection was confirmed. These data suggest that EFA is applicable for medico-biological studies. PMID: 25744771 [PubMed - in process] (Source: Medicina (Kaunas))



The role of parvovirus B19 and the immune response in the pathogenesis of acute leukemia

Sun, 01 Mar 2015 00:00:00 +0100

Summary In this article, we review the evidence suggesting a possible role for B19 virus in the pathogenesis of a subset of cases of acute leukemia. Human parvovirus B19 infection may complicate the clinical course of patients with acute leukemia and may also precede the development of acute leukemia by up to 180 days. Parvovirus B19 targets erythroblasts in the bone marrow and may cause aplastic crisis in patients with shortened‐red cell survival. Aplastic crisis represents a prodrome of acute lymphoblastic leukemia in 2% patients. There is a significant overlap between those HLA classes I and II alleles that are associated with a vigorous immune response and development of symptoms during B19 infection and those HLA alleles that predispose to development of acute leukemia. Acute symp...



Common Childhood Viral Infections

Fri, 20 Feb 2015 00:00:00 +0100

Infections caused by viruses are universal during childhood and adolescence. Clinicians will regularly care for children and adolescents who present with infections caused by a wide number of viral pathogens. These infections have varied presentations. Many infections may have clinical presentations that are specific to the infecting virus but present differently, based on the age and immunocompetence of the patient. Some children are directly impacted early in their lives when maternal disease results in an in utero infection (cytomegalovirus, rubella virus, or parvovirus B19). (Source: Current Problems in Pediatric and Adolescent Health Care)



Peptide display on a surface loop of human parvovirus B19 VP2: Assembly and characterization of virus-like particles.

Thu, 19 Feb 2015 00:00:00 +0100

Authors: Santillán-Uribe JS, Valadez-García J, Morán-García AD, Santillán-Uribe HC, Bustos-Jaimes I Abstract Virus-like particles (VLPs) are valuable tools for nanotechnology and nanomedicine. These particles are obtained by the self-assembly, either in vivo or in vitro, of structural proteins of viral capsids. VLPs are excellent scaffolds for surface display of molecules. The N-termini of the structural proteins of human parvovirus B19 (B19V) have been already modified to display peptides or proteins. However, other surface-exposed elements have not been studied as potential locations for peptide display. In this research, we tested the potential of surface loop 62-75 of VP2 protein for the presentation of a 64-residue heterologous peptide. The chimeric protein was able to se...

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