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MedWorm: Cytomegalovirus News



MedWorm.com provides a medical RSS filtering service. Thousands of medical RSS feeds are combined and output via different filters. This feed contains the latest news in Cytomegalovirus



Last Build Date: Wed, 24 Jan 2018 01:35:53 +0100

 



$8.9 million collaborative grant to understand how dangerous virus 'hides' to attack another day

Tue, 23 Jan 2018 05:00:00 +0100

(University of Arizona Health Sciences) Dr. Felicia Goodrum and several of the nation's most prominent human cytomegalovirus researchers have been awarded a five-year, $8.9 million collaborative grant to investigate how the virus lies dormant until it activates and poses life-threatening disease risk. (Source: EurekAlert! - Medicine and Health)

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Astellas and Vical Announce Top-Line Results for Phase 3 Trial of Cytomegalovirus Vaccine ASP0113 in Hematopoietic Stem Cell Transplant Recipients

Mon, 22 Jan 2018 12:33:08 +0100

TOKYO and SAN DIEGO, Jan. 22, 2018 -- (Healthcare Sales & Marketing Network) -- Astellas Pharma Inc. (TSE: 4503, President and CEO: Yoshihiko Hatanaka, "Astellas") and Vical Incorporated (NASDAQ: VICL) announced today that ASP0113, an investigat... Biopharmaceuticals Astellas Pharma, Vical , cytomegalovirus (Source: HSMN NewsFeed)



No Adverse Neurologic Hit From Postnatal CMV Infection in Preemies No Adverse Neurologic Hit From Postnatal CMV Infection in Preemies

Tue, 16 Jan 2018 21:02:18 +0100

Premature babies of mothers with cytomegalovirus who pick up the infection from breast milk are unlikely to develop neurological problems in early childhood as a result, according to a Dutch study.Reuters Health Information (Source: Medscape Pediatrics Headlines)



A common virus may help inform treatment planning for stem cell transplant patients

Thu, 07 Dec 2017 05:00:00 +0100

(Virginia Commonwealth University) a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of the human cytomegalovirus and the onset of graft-versus-host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant. (Source: EurekAlert! - Cancer)



Letermovir (Prevymis) Okayed for Stem Cell Transplant Infection Letermovir (Prevymis) Okayed for Stem Cell Transplant Infection

Thu, 09 Nov 2017 19:11:41 +0100

The drug prevents cytomegalovirus infections and disease in adults previously exposed to the common virus who have received an allogeneic hematopoietic stem cell transplant.FDA Approvals (Source: Medscape Medical News Headlines)



FDA Approves Prevymis (letermovir) for Prevention of Cytomegalovirus (CMV) Infection and Disease in Adult Allogeneic Stem Cell Transplant Patients

Thu, 09 Nov 2017 01:11:18 +0100

KENILWORTH, N.J.--(BUSINESS WIRE) November 9, 2017 --Merck& Co., Inc. (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved Prevymis (letermovir) once-daily... (Source: Drugs.com - New Drug Approvals)

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Study: therapists lack knowledge to prevent transmission of CMV

Wed, 04 Oct 2017 04:00:00 +0100

(Midwestern University) Results from a new health-risk knowledge survey indicate that physical and occupational therapists are at increased risk of contracting cytomegalovirus (CMV), a leading cause of prenatal infection and lifelong disabilities, but that they lack sufficient knowledge to prevent its transmission. (Source: EurekAlert! - Infectious and Emerging Diseases)



Immune system cells protect against CMV-induced hearing loss in mice

Thu, 28 Sep 2017 04:00:00 +0100

(PLOS) Immune system cells known as natural killer cells play an important protective role against hearing loss in mice infected with cytomegalovirus (CMV), according to a new study published in PLOS Pathogens. (Source: EurekAlert! - Social and Behavioral Science)



What Causes Microcephaly?

Mon, 25 Sep 2017 00:22:33 +0100

Discussion Microcephaly is usually defined as an occipitofrontal head circumference (OFC) more than 2 standard deviations (SD) below the mean for sex, age and ethnicity. Severe microcephaly is used for OFC < 3 standard deviations. Rates of microcephaly range from 0.5-12 patients/10,000 live births. The OFC should be measured at every well child visit and at other opportunities and plotted on standard growth charts. The OFC is measured using a nonelastic tape measure around the largest part of the head with the tape measure held above the eyebrows and ears. It is a highly reproducible measurement. There are several different international standard growth charts that can be used and those used should reflect the population the patient is drawn from the best. For example, the World Health...



Treating a little-known virus, CMV, to combat hearing loss in children

Thu, 14 Sep 2017 04:00:00 +0100

(University of Utah Health) A National Institutes of Health-supported nationwide clinical trial will test a novel approach to combat hearing loss in children infected by a relatively unknown virus, cytomegalovirus (CMV). The University of Utah Health-led study will determine whether antiviral therapy can halt progressive hearing loss in children with a confirmed CMV infection. CMV is the leading non-genetic cause of hearing loss, contributing from 6 to 30 percent of childhood cases. (Source: EurekAlert! - Infectious and Emerging Diseases)



Team led by UCLA, UCSF receives $8 million to study virus that often strikes after kidney transplants

Thu, 24 Aug 2017 16:46:00 +0100

UCLA, UC San Francisco and City of Hope have received a five-year, $8 million grant from the National Institute of Allergy and Infectious Diseases to study how a common virus called cytomegalovirus may provoke the immune system to reject transplanted kidneys.The 14-member interdisciplinary team is co-led by Elaine Reed, who holds the Daljit S. and Elaine Sarkaria Endowed Chair in Diagnostic Medicine at UCLA and is director of the UCLA Immunogenetics Center.  “Nearly 70 percent of people around the world carry antibodies to the cytomegalovirus infection, yet healthy people rarely display symptoms,” said Reed, who also is a professor of pathology at the David Geffen School of Medicine at UCLA. “In a transplant patient, however, CMV is one of the lea ding causes of organ failure and de...

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NIAID herpesvirus study in mice leads to discovery of potential broad-spectrum antiviral

Tue, 15 Aug 2017 04:00:00 +0100

(NIH/National Institute of Allergy and Infectious Diseases) NIAID scientists studying herpes simplex virus infection have unexpectedly found that inhibiting a cellular enzyme complex, EZH2/1, suppresses viral infection. The researchers then demonstrated that EZH2/1 inhibitors also enhanced the cellular antiviral response in cultured cells and mice. They then showed that EZH2/1 inhibitors suppressed HSV infection, spread, and reactivation in mice and, in cell culture, suppressed human cytomegalovirus, adenovirus, and Zika virus infections. They suggest that EZH2/1 inhibitors have considerable potential as broad-spectrum antivirals. (Source: EurekAlert! - Medicine and Health)



Issues with maternal screening for congenital cytomegalovirus infection

Mon, 24 Jul 2017 04:00:00 +0100

(Kobe University) Human cytomegalovirus (CMV) is a common virus found worldwide. When CMV infects fetuses, it can cause serious complications such as hearing difficulties and mental retardation in affected infants. A group of researchers have evaluated for the first time the efficacy of maternal universal screening using CMV IgG avidity tests for congenital CMV infection, and they have also identified issues with the current maternal CMV screening methods. (Source: EurekAlert! - Infectious and Emerging Diseases)



What Conditions is Erythema Nodosum Associated With?

Mon, 24 Jul 2017 00:26:28 +0100

Discussion Erythema nodosum (EN) is a common dermatological eruption characterized by inflammatory nodules of the subcutaneous fat (panniculitis) on the extensor surfaces of the extremities especially the shins, thighs, and forearms. They are usually painful, nodular, bilateral and multiple. They can be found on other areas and be unilateral. They can be red, purple or blackish. They usually resolve without problems in 3-6 weeks. Diagnosis is usually clinical but biopsy may be needed if there is atypical presentation or history, physical examination or laboratory testing reveals potential underlying diseases. Treatment is usually conservative with rest and non-steroidal anti-inflammatory drugs. Identified underlying causes of the EN should be treated but in some studies more than 50% of t...



Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150

Thu, 29 Jun 2017 00:00:00 +0100

Herpesviruses possess a genome-pressurized capsid. The 235-kilobase genome of human cytomegalovirus (HCMV) is by far the largest of any herpesvirus, yet it has been unclear how its capsid, which is similar in size to those of other herpesviruses, is stabilized. Here we report a HCMV atomic structure consisting of the herpesvirus-conserved capsid proteins MCP, Tri1, Tri2, and SCP and the HCMV-specific tegument protein pp150—totaling ~4000 molecules and 62 different conformers. MCPs manifest as a complex of insertions around a bacteriophage HK97 gp5–like domain, which gives rise to three classes of capsid floor–defining interactions; triplexes, composed of two "embracing" Tri2 conformers and a "third-wheeling" Tri1, fasten the capsid floor. HCMV-specific strategies include ...



HIV-positive women with cytomegalovirus likelier to pass virus that causes AIDS to infant

Thu, 22 Jun 2017 00:03:13 +0100

HIV-positive women with cytomegalovirus, or CMV, in their urine at the time of labor and delivery are more than five times likelier than HIV-positive women without CMV to transmit HIV, the virus that causes AIDS, to their infants, according to a UCLA-led study.The research also found that they are nearly 30 times likelier to transmit cytomegalovirus to their infants.Dr. Karin Nielsen, a professor of clinical pediatrics in the division of infectious diseases at theDavid Geffen School of Medicine at UCLA, is the senior author of the study, which was published today in the journal Clinical Infectious Diseases.“The findings were surprising because prior studies in healthy pregnant women have not shown an association between CMV detection in urine, or even cervical secretions, and congenital ...

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Congenital Cytomegalovirus Infection: Management Update Congenital Cytomegalovirus Infection: Management Update

Fri, 16 Jun 2017 04:14:39 +0100

This review provides an update on the available management strategies for congenital cytomegalovirus infection and discusses promising new treatment options.Current Opinion in Infectious Diseases (Source: Medscape Today Headlines)



Disease Awareness Months Work, Even If You Don't Wear The Ribbon

Fri, 02 Jun 2017 16:49:41 +0100

June ​is the month for more than 10 disease-related awareness campaigns, including Myasthenia Gravis Awareness Month, National Congenital Cytomegalovirus Awareness Month and National Scleroderma Awareness Month. It also hosts a handful of awareness weeks and days, ranging from Helen Keller Deaf-Blind Awareness Week to World Sickle Cell Day. June’s awareness list is shorter than most, but every month is full of diseases and disorders to take note of. You probably haven’t heard of half of them, and you’re not alone. So what’s the point of an awareness day, week or month? To understand the challenges of catching public attention, consider National Autism Awareness Month (that’s April), which began in the 1970s as a nationwide campaign led by the National A...



Virus study targets infection linked to birth defects

Mon, 15 May 2017 13:54:39 +0100

Fresh insights into how a common virus replicates could pave the way for new therapies to stop its spread. Scientists have discovered a key molecule linked to Human Cytomegalovirus (HCMV) infection, which is harmless for healthy people but can cause miscarriage and birth defects during pregnancy. (Source: ScienceDaily Headlines)



Scientists ID human protein essential for human cytomegalovirus replication

Thu, 11 May 2017 20:53:53 +0100

Scientists have demonstrated that a human protein known as valosin containing protein (VCP) is essential for replication of human cytomegalovirus (HCMV). The findings identify VCP as a potential new treatment target. (Source: ScienceDaily Headlines)



Vaccine/Chemotherapy Combination Improves Survival in Glioblastoma

Sun, 16 Apr 2017 11:00:00 +0100

Cytomegalovirus targeted vaccination plus high-dose chemotherapy with temozolomide can lead to long-term progression-free and overall survival in patients with newly diagnosed glioblastoma. (Source: CancerNetwork)



Glioblastoma patients may benefit from a vaccine-chemotherapy combination

Fri, 14 Apr 2017 04:00:00 +0100

(American Association for Cancer Research) A vaccine targeting cytomegalovirus (CMV) antigen pp65, combined with high-dose chemotherapy (temozolomide), improved both progression-free survival and overall survival for a small group of glioblastoma (GBM) patients. (Source: EurekAlert! - Medicine and Health)



Virus vs. host: Exposing an evolutionary arms race

Mon, 10 Apr 2017 13:56:35 +0100

Scientists have solved a 40-year old mystery and shed light on an evolutionary arms race played out between cytomegalovirus (CMV) and the immune system. (Source: ScienceDaily Headlines)

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The Boston Marathon: Brave and beyond

Mon, 10 Apr 2017 12:00:37 +0100

Brave. It’s the word inscribed on the simple band Mary Tremper wears on her left wrist. The band is a reminder from her son Shane that she possesses the strength and courage to bravely face the future. When Mary, a Boston Children’s Hospital Miles for Miracles runner, found the band in the hospital gift shop she knew it was from Shane. And as Mary has shared her son’s story with her teammates and listened to theirs, they have redefined brave, together. A few of their stories, including the Tremper’s, follow. Brave: Remembering Shane Shane in the Boston Children’s NICU. “I run for Shane. I run because he can’t. I run because I can. I run for Shane.” This is Mary Tremper’s mantra. Shane, born May 6, 2016, was the Tremper’s second beautiful baby boy. The day af...



Virus vs. host -- New research exposes an evolutionary arms race

Sun, 09 Apr 2017 04:00:00 +0100

(Monash University) Imaging CoE scientists have solved a 40-year old mystery and shed light on an evolutionary arms race played out between cytomegalovirus (CMV) and the immune system. (Source: EurekAlert! - Infectious and Emerging Diseases)



What Causes Uveitis?

Mon, 03 Apr 2017 13:34:44 +0100

Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and > 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increases with age with the highest incidence and prevalence in > 65 year olds. Only ~10% of uveitis occurs in the pediatric age group. Uveitis can be difficult to identify i...



Atara Bio Expands Management Team, Appoints Joe Newell as Executive Vice President, Chief Technical Operations Officer

Mon, 03 Apr 2017 13:15:49 +0100

SOUTH SAN FRANCISCO, Calif., April 03, 2017 -- (Healthcare Sales & Marketing Network) -- Atara Biotherapeutics, Inc. (ATRA), a biopharmaceutical company developing meaningful therapies for patients with severe and life-threatening diseases that have been u... Biopharmaceuticals, Personnel Atara Biotherapeutics, Epstein-Barr Virus, Cytomegalovirus (Source: HSMN NewsFeed)



Study Casts Doubt on a Brain Cancer ’ s Link to Herpes

Tue, 07 Mar 2017 22:00:00 +0100

Researchers find no evidence of cytomegalovirus in tumor tissue (Source: The Doctors Lounge - Oncology)

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Study Casts Doubt on A Brain Cancer's Link to Herpes

Tue, 07 Mar 2017 21:00:00 +0100

Researchers find no evidence of cytomegalovirus in tumor tissue Source: HealthDay Related MedlinePlus Pages: Brain Tumors, Cytomegalovirus Infections (Source: MedlinePlus Health News)



Study Casts Doubt on a Brain Cancer ’ s Link to Herpes

Mon, 06 Mar 2017 23:00:00 +0100

Researchers find no evidence of cytomegalovirus in tumor tissue (Source: The Doctors Lounge - Oncology)



Study finds no evidence of common herpes type virus in aggressive brain cancer tissue

Tue, 28 Feb 2017 05:00:00 +0100

(Johns Hopkins Medicine) In a rigorous study of tumor tissue collected from 125 patients with aggressive brain cancers, researchers at Johns Hopkins say they have found no evidence of cytomegalovirus (CMV) infection and conclude that a link between the two diseases, as claimed by earlier reports, likely does not exist. (Source: EurekAlert! - Cancer)



Merck ’s letermovir meets primary endpoint in Phase III trial to prevent CMV infection

Tue, 28 Feb 2017 00:00:00 +0100

Healthcare firm Merck has reported positive results from the Phase III clinical trial of anti-viral drug letermovir to prevent cytomegalovirus (CMV) infection in recipients of bone marrow transplant. (Source: Drug Development Technology)



Merck ’s Letermovir, an Investigational Antiviral Medicine for Prevention of Cytomegalovirus (CMV) Infection in Bone Marrow Transplant Recipients, Highly Effective Through Week 24 Post-Transplant in Pivotal Phase 3 Study

Sun, 26 Feb 2017 17:30:00 +0100

Dateline City: KENILWORTH, N.J. Letermovir Prophylaxis Associated with Lower All-Cause Mortality Through Week 24 Post-Transplant Company Plans to Submit New Drug Applications for Letermovir in U.S. and EU in 2017KENILWORTH, N.J.--(BUSINESS WIRE)--Merck& Co., Inc. (NYSE:MRK), known as MSD outside the United States and Canada, today announced results of the pivotal Phase 3 clinical study of letermovir, an investigational antiviral medicine for the prevention of clinically-significant cytomegalovirus (CMV) infection in adult (18 years and older) CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT), also known as bone marrow transplant (BMT).Language: EnglishContact: MerckMedia:Pam Eisele, 267-305-3558Robert Consalvo, 908-236-...

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New antiviral drug cuts cytomegalovirus infection, improves survival in patients undergoing donor stem cell transplant

Fri, 24 Feb 2017 17:17:42 +0100

In a significant advance in improving the safety of donor stem cell transplants, a major clinical trial has shown that a novel agent can protect against the most common viral infection that patients face after transplantation. (Source: ScienceDaily Headlines)



Ties: My Daughter ’ s Silent Virus: Congenital CMV

Fri, 24 Feb 2017 12:00:01 +0100

To protect your baby from a disabling disease, first you have to know that it exists. (Source: NYT Health)



Link between herpes in pregnancy and autism is unconfirmed

Fri, 24 Feb 2017 12:00:00 +0100

Conclusion This was a Norwegian case-control study that looked at whether maternal infections during pregnancy are associated with the risk of neurological developmental disorders such as autism spectrum disorders (ASDs) in their children. The study initially found no association between any of the pathogens during pregnancy or after delivery, and the development of ASD in boys or girls. Further investigations suggested that high levels of HSV-2 virus antibodies during mid-pregnancy were associated with increased risk of the development of ASD in boys. The researchers suggest that the suspected risk of ASD associated with high levels of virus is not down to the HSV-2 virus itself but the impact of inflammation and the subsequent activation of the immune system on child development during...



New antiviral drug cuts cytomegalovirus infection and improves survival in patients

Fri, 24 Feb 2017 05:00:00 +0100

(Dana-Farber Cancer Institute) In a significant advance in improving the safety of donor stem cell transplants, a major clinical trial led by researchers at Dana-Farber Cancer Institute has shown that a novel agent can protect against the most common viral infection that patients face after transplantation. (Source: EurekAlert! - Medicine and Health)



Merck drug prevents serious infection after marrow transplant: study

Thu, 23 Feb 2017 18:53:06 +0100

(Reuters) - An experimental Merck& Co drug succeeded in preventing clinically serious cytomegalovirus (CMV) following bone marrow transplant and was associated with a lower death rate compared with placebo in a late state study, the company said. (Source: Reuters: Health)

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Common Virus May Be Linked to Heart Disease, Diabetes in Some Women

Thu, 23 Feb 2017 14:00:00 +0100

CMV associated with increased chances of metabolic syndrome in those of normal weight Source: HealthDay Related MedlinePlus Pages: Cytomegalovirus Infections, Metabolic Syndrome, Women's Health (Source: MedlinePlus Health News)



Ocular Complications of Congenital Infections

Tue, 31 Jan 2017 23:00:00 +0100

This article summarizes the ocular complications of the 5 infections typically represented by the acronym TORCHES (toxoplasmosis, rubella, cytomegalovirus, herpes simplex, and syphilis), as well as others, including newer pathogens such as the human immunodeficiency, West Nile, and Zika viruses. (Source: NeoReviews recent issues)



January is Birth Defects Prevention Month

Thu, 26 Jan 2017 17:35:05 +0100

Untitled by Tim Bish is licensed under CC0. January is Birth Defects Prevention Month and several states in our region want to inform residents about what can be done. In the U.S., birth defects affect 1 in 33 babies and cause 1 in 5 infant deaths every year, according to the U.S. Centers for Disease Control and the National Birth Defects Prevention Network (NBDPN). The Oklahoma State Department of Health (OSDH), in partnership with NBDPN, hopes to raise awareness for infections like cytomegalovirus (CMV), which can cause birth defects. CMV is a common infection which affects more than half of U.S. adults by age 40 and which often doesn’t make those who are infected ill. However, if a pregnant women gets the infection, it can spread to the unborn child, called congenital CMV. Only about ...



Law aiding infants at risk for hearing loss

Tue, 24 Jan 2017 19:07:52 +0100

A Utah law has led to increased early identification of infants with hearing loss due to a congenital infection, according to a new study. The study is the first to assess how implementation of a state-wide screening can pick up hearing loss in infants due to congenital cytomegalovirus. (Source: ScienceDaily Headlines)



Researchers develop new compound to fight cytomegalovirus

Tue, 10 Jan 2017 17:05:55 +0100

A Retro94-based compound may prevent a common and sometimes fatal virus -- human cytomegalovirus (CMV) -- from reproducing and help to protect immunocompromised patients, such as those with HIV, on chemotherapy, with transplants, and infants from the effects of the disease, according to researchers. (Source: ScienceDaily Headlines)

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ViraCyte Granted U.S. FDA Fast Track Designation for Viralym-C

Tue, 10 Jan 2017 15:10:41 +0100

SAN FRANSICSCO, Jan. 10, 2017 -- (Healthcare Sales & Marketing Network) -- ViraCyte, LLC today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation for Viralym-C, ViraCyte's T cell immunotherapy product designed to... Biopharmaceuticals, FDA ViraCyte, Viralym-C, immunotherapy, cytomegalovirus (Source: HSMN NewsFeed)



Researchers develop new compound to fight cytomegalovirus

Tue, 10 Jan 2017 05:00:00 +0100

(Penn State) A Retro94-based compound may prevent a common and sometimes fatal virus -- human cytomegalovirus (CMV) -- from reproducing and help to protect immunocompromised patients, such as those with HIV, on chemotherapy, with transplants, and infants from the effects of the disease, according to Penn State College of Medicine researchers. (Source: EurekAlert! - Infectious and Emerging Diseases)



Genetic mutations could increase risk of cytomegalovirus infection

Tue, 20 Dec 2016 05:00:00 +0100

(Johns Hopkins Medicine) Experimenting with human cells and mice, Johns Hopkins researchers have found that a genetic mutation that alters a protein called NOD1 may increase susceptibility to human cytomegalovirus (CMV) infection. CMV is a common pathogen that infects almost 60 percent of adults in the US, according to the Centers for Disease Control and Prevention (CDC), and can lead to devastating developmental defects in fetuses and severe disease in people with weakened immune systems. (Source: EurekAlert! - Medicine and Health)



Medical News Today: Congenital herpes virus tied to common childhood cancer

Mon, 19 Dec 2016 15:00:00 +0100

Children who develop acute lymphoblastic leukemia are over three times more likely to have tested positive for cytomegalovirus at birth, a new study shows. (Source: Health News from Medical News Today)



Woman who got 'a bad cold' during pregnancy is shocked to discover she passed common but little-known virus to her unborn baby which left him profoundly deaf

Mon, 19 Dec 2016 06:19:09 +0100

Queensland mother Rebekka Murray contracted Cytomegalovirus (CMV) for the first time while pregnant, passing the virus on to her unborn baby. (Source: the Mail online | Health)

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Herpes virus linked to most common type of childhood cancer

Thu, 15 Dec 2016 23:00:00 +0100

Congenital cytomegalovirus infection may increase risk of developing acute lymphocytic leukaemia Related items fromOnMedica Cold sore virus could kill cancer New guidelines on managing genital herpes in pregnancy Scientists find genetic signature linked to leukaemia Breastfeeding could cut children ’s leukaemia risk Prophylactic antibiotics help children with leukaemia (Source: OnMedica Latest News)



As CRISPR fight drones on, Peninsula startup puts gene-editing technology to work

Sat, 10 Dec 2016 09:13:44 +0100

No matter how well viruses are beaten back by modern-day medicines, tiny pools remain that can reemerge. Consider startup Agenovir Corp. the lifeguard that forces everyone out of the pool. At least that's what the South San Francisco company aspires to do, using the highly touted, DNA-snipping CRISPR-Cas9 technology to create topical treatments targeting immune system-weakening cytomegalovirus, cervical cancer-causing human papillomavirus and other viral infections. The company — the latest in… (Source: bizjournals.com Health Care:Biotechnology headlines)



CMV Remains a Concern Because of Lack of Research CMV Remains a Concern Because of Lack of Research

Fri, 02 Dec 2016 21:06:07 +0100

ACOG representatives respond to a recent New York Times article highlighting the fact that few ob/gyns counsel pregnant women about avoiding cytomegalovirus.Medscape Ob/Gyn (Source: Medscape Today Headlines)



Cytomegalovirus: The Virus All Pregnant Women Should Know About Now Cytomegalovirus: The Virus All Pregnant Women Should Know About Now

Fri, 02 Dec 2016 15:27:36 +0100

Teaching women about CMV prevention strategies can help them avoid getting the virus and passing it to their offspring, Dr Gail Demmler-Harrison says.Medscape Ob/Gyn (Source: Medscape ObGyn and Womens Health Headlines)



Cytomegalovirus (CMV)

Fri, 02 Dec 2016 07:00:00 +0100

Title: Cytomegalovirus (CMV)Category: Diseases and ConditionsCreated: 11/7/2000 12:00:00 AMLast Editorial Review: 12/2/2016 12:00:00 AM (Source: MedicineNet HIV General)



New method for predicting congenital congenital cytomegalovirus infection during the prenatal period

Fri, 25 Nov 2016 13:42:21 +0100

Congenital cytomegalovirus (CMV) infection can cause serious complications such as hearing difficulties and mental delay in affected infants. A research team has discovered a new method for predicting congenital CMV infection during the prenatal period. This method is safe for both mothers and fetuses, and could potentially be adopted for general use, report researchers. (Source: ScienceDaily Headlines)



New method for predicting congenital CMV infection during the prenatal period

Fri, 25 Nov 2016 05:00:00 +0100

(Kobe University) Congenital cytomegalovirus (CMV) infection can cause serious complications such as hearing difficulties and mental retardation in affected infants. A Japanese research team has discovered a new method for predicting congenital CMV infection during the prenatal period. This method is safe for both mothers and fetuses, and could potentially be adopted for general use. The findings were published on Oct. 20 in the online version of Clinical Infectious Diseases. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Congenital virus in children with cerebral palsy more common than thought

Mon, 14 Nov 2016 05:00:00 +0100

(University of Sydney) Congenital infection with cytomegalovirus is more common in children with cerebral palsy than previously thought, a new Australian study has reported in the Journal of Pediatrics. (Source: EurekAlert! - Infectious and Emerging Diseases)



Cytogam (Cytomegalovirus Immune Globulin Intravenous Human) - updated on RxList

Tue, 08 Nov 2016 07:00:00 +0100

(Source: RxList - New and Updated Drug Monographs)



Maribavir Back on Table as Option for Cytomegalovirus Maribavir Back on Table as Option for Cytomegalovirus

Thu, 03 Nov 2016 16:12:42 +0100

For transplant patients resistant or refractory to treatment for cytomegalovirus (CMV) infection, maribavir could be an option, new research shows, but it might increase the rate of relapse.Medscape Medical News (Source: Medscape Medical News Headlines)



Shire reports positive Phase II study results of maribavir to treat cytomegalovirus infection

Mon, 31 Oct 2016 00:00:00 +0100

Shire has reported positive data results from a Phase 2 study analysing maribavir (SHP620), an investigational anti-viral agent studied in patients with cytomegalovirus (CMV) infection undergoing hematopoietic stem cell transplant or solid organ tran … (Source: Drug Development Technology)



Zika Causes Deafness In About 6 Percent Of Cases

Wed, 31 Aug 2016 16:38:01 +0100

A study in Brazil of 70 babies whose mothers had confirmed Zika infections found that nearly 6 percent had hearing loss, adding a new complication to the list of ills the virus can cause when women are infected during pregnancy. The Brazilian study, published on Tuesday in the U.S. Centers for Disease Control and Prevention’s weekly report on death and disease, confirmed less rigorous reports of deafness among infants born to mothers with Zika infections. The finding is part of an effort to fully characterize the harm caused by the Zika virus during pregnancy. The virus is best known for causing the severe birth defect microcephaly, characterized by undersized heads and underdeveloped brains. But other studies have shown that Zika can cause other brain abnormalities, vision problems ...

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VBI Vaccines to continue enrolment for Phase I trial of CMV vaccine candidate

Mon, 22 Aug 2016 23:00:00 +0100

VBI Vaccines has been recommended to continue enrolling patients for its Phase I clinical study in order to evaluate its preventative cytomegalovirus (CMV) vaccine candidate. (Source: Drug Development Technology)



Microcephaly Isn’t The Only Threat Zika Virus Poses To Newborns

Wed, 10 Aug 2016 00:05:45 +0100

The most commonly known birth defect caused by Zika virus is microcephaly, a condition in which an infant’s head circumference is smaller than average. It can indicate brain damage and lifelong learning and mental disabilities for the child.  Now a new study is shedding light on yet another serious condition that can Zika virus can cause in infants.  Arthrogryposis, a condition in which the body’s joints are malformed, preventing normal flexion and extension, should be added to the list of potential consequences for newborns whose mothers were infected with Zika virus, according to researchers in Recife, Brazil. Before 2015, arthrogryposis in infants had not been linked to a maternal viral infection. Instead, it was usually linked to fetal akinesia, when a fetus does ...



When Is the Clinical Nadir for Guillain-Barr é Syndrome?

Mon, 08 Aug 2016 00:49:09 +0100

Discussion Guillian-Barré syndrome (GBS) is an acquired, acute, inflammatory, demyelinating polyneuropathy. It is the most common cause of acute and subacute flaccid paralysis in children. GBS causes about 0.4-1.3 cases per 100,000 persons/year in children. It can occur in any age group and the incidence increases among all age groups until a peak in the 50s. Both genders are affected and there may be a slight increase in males. GBS usually occurs 2-4 weeks after a prodromonal gastroenteritis or respiratory illness. It is most often associated with Campylobacter jejunae, Haemophilus infuenza, Mycoplasma pneumoniae, cytomegalovirus, Epstein-Barr virus, and herpes simplex virus. There are some possible associations with GBS and influenza A vaccination but it has not been associated w...



These Are The Heroes Looking Out For Brazil's Microcephaly Babies

Fri, 05 Aug 2016 17:34:48 +0100

RECIFE, Brazil ― This poverty-stricken city in the country’s northeast is ground zero for the Zika virus, and many mothers here have given birth to babies with microcephaly. As poor and often single women face a disease that can cause severe disabilities in their children, medical professionals and women’s rights activists have rallied to provide them with support and information. At the AACD physiotherapy unit, Dr. Ana Patrícia treats up to 15 children with microcephaly on any given day. And all the treatment is free for patients. Patrícia says that the center has seen an uptick in patients with microcephaly since March. One of these patients is 13-month-old José Bernardo Da Silva. His mother, Adriana, travels six hours from her home in Custodia, which i...

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UAB researchers awarded $11.5 million to study asymptomatic congenital CMV and neonatal HSV

Mon, 18 Jul 2016 04:00:00 +0100

(University of Alabama at Birmingham) The NIH recently awarded UAB $11.5 million to support studies that will assess treatment of babies born with congenital cytomegalovirus but no symptoms, and frequency of neonatal herpes infections in the United States and Peru. (Source: EurekAlert! - Infectious and Emerging Diseases)



UAB research team awarded $11.5M contract

Fri, 15 Jul 2016 13:28:40 +0100

A group of researchers at the University of Alabama at Birmingham was recently awarded an $11.5 million contract to study treatment of babies born with congenital cytomegalovirus and frequency of neonatal herpes infections in the United States and Peru. The National Institute of Allergy and Infectious Disease awarded the funding to the UAB Department of Pediatrics to support two studies slated to be conducted at UAB and its partner academic sites. Nearly 1 percent of babies born in the United States… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)



Teaching an old drug new tricks to fight cytomegalovirus

Mon, 27 Jun 2016 18:06:45 +0100

An old drug once mostly used to treat amebiasis -- a disease caused by a parasite -- and induce vomiting in cases of poisoning appears to also halt replication of cytomegalovirus (CMV), a herpesvirus that can cause serious disease in immunocompromised individuals, including those with HIV or organ transplant recipients, report researchers. (Source: ScienceDaily Headlines)



Disrupted immunity in fetal brain is linked to neurodevelopmental disorders

Mon, 27 Jun 2016 16:53:10 +0100

New research findings in mice may help explain how viral infection during pregnancy raises the risk of autism and schizophrenia in their offspring. The study may explain, among other things, how the mother's infection with the cytomegalovirus (CMV) during pregnancy, which affects her own and her fetus's immune system, increases the risk that her offspring will develop autism or schizophrenia, sometimes years later. (Source: ScienceDaily Headlines)



Teaching an old drug new tricks to fight cytomegalovirus

Mon, 27 Jun 2016 04:00:00 +0100

(Johns Hopkins Medicine) Researchers at Johns Hopkins have found that an old drug once mostly used to treat amebiasis -- a disease caused by a parasite -- and induce vomiting in cases of poisoning appears to also halt replication of cytomegalovirus (CMV), a herpesvirus that can cause serious disease in immunocompromised individuals, including those with HIV or organ transplant recipients. (Source: EurekAlert! - Medicine and Health)

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Roche announces the first FDA-approved CMV test for use in hematopoietic stem cell transplant recipients

Wed, 25 May 2016 13:35:13 +0100

New test standardizes CMV testing for both solid organ and hematopoietic stem cell transplant recipients PLEASANTON, Calif., May 25, 2016 -- (Healthcare Sales & Marketing Network) -- Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the United States ... Diagnostics, FDARoche, Roche Group, cytomegalovirus (Source: HSMN NewsFeed)



Vaccine Boosts Glioblastoma SurvivalVaccine Boosts Glioblastoma Survival

Thu, 12 May 2016 20:13:00 +0100

A novel combination of cytomegalovirus-targeted dendritic cell vaccine and tetanus preconditioning shows a significant increase in survival and improved immune response in glioblastoma. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)



What viruses do to neuronal stem cells -- effects of congenital transmission

Thu, 14 Apr 2016 04:00:00 +0100

(PLOS) Congenital transmission (from mother to unborn child) of viruses can cause abnormal brain development in the fetus. Examples of viruses that can pass through the placenta and into the fetal brain include cytomegalovirus, rubella, and zika virus. A study published on April 14th in PLOS Pathogens examines the effects of human cytomegalovirus (HCMV) infection on neuronal stem cells and reports that the virus delays or prevents proper differentiation of the stem cells into mature brain cells by activating a key signaling pathway. (Source: EurekAlert! - Infectious and Emerging Diseases)



Analytic Vaccinology: Antibody-Driven Design of a Human Cytomegalovirus Subunit Vaccine

Fri, 08 Apr 2016 22:00:00 +0100

Identification of the most relevant protective antigens has represented a considerable obstacle for the development of subunit vaccines against viral infections, including human cytomegalovirus (HCMV) infection. This chapter describes the method of analytic vaccinology, centered on the clonal analysis of human B cell response to HCMV, which represents an essential tool for assessing the impact of individual viral antigens in the antiviral antibody response. By providing key information on the immunogenicity and protective properties of the antibodies elicited by viral proteins, the analytic vaccinology method guides the selection of the most appropriate vaccine candidates. Here we discuss methodologies for the generation of human monoclonal antibodies from B cells of immune donors, antibod...



What Genetics are Associated with Multiple Sclerosis?

Mon, 04 Apr 2016 00:28:08 +0100

Discussion Multiple sclerosis (MS) is “a chronic degenerative, often episodic disease of the central nervous system marked by patchy destruction of the myelin that surrounds and insulates nerve fibers, usually appearing in young adulthood and manifested by one or more mild to severe neural and muscular impairments, as spastic weakness in one or more limbs, local sensory losses, bladder dysfunction, or visual disturbances.” It is a chronic disease and therefore symptoms must occur more than once. The first episode is called an acute demyelinating attack. Fifteen to forty-five percent of children with their first attack will go on to have others and therefore later be diagnosed with MS. Because pediatric patients have high relapse rates, diagnosis often is within a year of the in...

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Threat of cytomegalovirus far outweighs Zika risk, researcher says

Mon, 15 Feb 2016 19:36:19 +0100

Researcher studies the impact of CMV on healthcare providers. (Source: ScienceDaily Headlines)



New study highlights effectiveness of a herpesvirus CMV-based vaccine against Ebola

Mon, 15 Feb 2016 05:00:00 +0100

(University of Plymouth) As the latest in a series of studies, researchers have shown the ability of a vaccine vector based on a common herpesvirus called cytomegalovirus (CMV) expressing Ebola virus glycoprotein (GP), to provide protection against Ebola virus in the experimental rhesus macaque, non-human primate (NHP) model. Demonstration of protection in the NHP model is regarded as a critical step before translation of Ebola virus vaccines into humans and other great apes. (Source: EurekAlert! - Infectious and Emerging Diseases)



[Report] Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

Fri, 12 Feb 2016 00:00:00 +0100

Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in the regulation of natural killer (NK) cells. We found that vaccinating rhesus macaques with rhesus cytomegalovirus vectors in which genes Rh157.5 and Rh157.4 are deleted results in MHC-E–restricted presentation of highly varied peptide epitopes to CD8αβ+ T cells, at ~4 distinct epitopes per 100 amino acids in all tested antigens. Computational structural analysis revealed that MHC-E provides heterogeneous chemical environments for diverse side-chain interactions within a stable, open binding groove. Because MHC-E is up-regulated to evade NK cell activity in cells infected with HIV, simian immunodeficiency vi...



The Latest On Zika: New Countries Are Added To The CDC's Watch List

Tue, 02 Feb 2016 20:15:29 +0100

On Monday the U.S. Centers for Disease Control and Prevention added four countries and territories to its growing list of places with active Zika virus transmissions, which means that the cases occurred locally, rather than in travelers returning from a place where they acquired the virus. So far, no local cases of Zika have been reported in the United States.  The virus, which is spread by the Aedes aegypti mosquito, is strongly suspected to be linked to a new wave of microcephaly cases in Brazil. Babies born with the birth defect have smaller heads and brains that aren't fully developed, which can result in life-long developmental problems.    With the high volume of news about the Zika virus, it's tough to stay up-to-date. Check out our full coverage, or re...

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Brazil Wages War against Zika Virus on Several Fronts

Tue, 02 Feb 2016 14:08:52 +0100

In the country’s capital, Brazilian President Dilma Rousseff oversees one of the military operations against the Aedes Aegypti mosquito carried out at a national level in the last few days to curb the spread of the Zika virus. Credit: Roberto Stuckert Filho/PRBy Mario OsavaRIO DE JANEIRO, Feb 2 2016 (IPS)Brazil is deploying 220,000 troops to wage war against the Zika virus, in response to the alarm caused by the birth of thousands of children with abnormally small heads. But eradicating the Aedes aegypti mosquito requires battles on many fronts, including science and the pharmaceutical industry.The Zika virus, transmitted by the Aedes aegypti mosquito, like dengue and Chikungunya fever, is blamed for the current epidemic of microcephaly, which has frightened people in Brazil and could hu...



Q&A: Zika virus in mothers linked with microcephaly in babies in Brazil

Mon, 11 Jan 2016 13:59:07 +0100

You may have heard the news: Brazil is facing a startling outbreak of microcephaly, a rare condition in which an infant is born with a head much smaller than it should be. Microcephaly almost always causes significant brain damage and can be life threatening. The epidemic has been linked to a simultaneous influx of the mosquito-borne virus Zika. Thriving spoke with Dr. Ganeshwaran Mochida, a pediatric neurologist at Boston Children’s Hospital who specializes in microcephaly, and Dr. Asim Ahmed, an infectious disease researcher at Boston Children’s who specializes in mosquito-borne illnesses, to find out more about the situation and what you can do to keep your family safe. What is microcephaly? Mochida: Microcephaly is not a single disease.  It actually refers to a condition in whic...



Chimerix Antiviral Drug Fails in Late-Stage StudyChimerix Antiviral Drug Fails in Late-Stage Study

Tue, 29 Dec 2015 18:13:05 +0100

Chimerix Inc said its oral antiviral drug brincidofovir did not significantly reduce cytomegalovirus (CMV) infection through week 24 after hematopoietic stem cell transplant in a late-stage study, sending its shares down 72% in premarket trading Monday. Reuters Health Information (Source: Medscape Pathology Headlines)



Chimerix Announces Top-Line Results From Phase 3 SUPPRESS Trial of Brincidofovir

Mon, 28 Dec 2015 14:49:03 +0100

SUPPRESS Did Not Achieve Primary Endpoint for Prevention of Clinically Significant CMV Infection After HCT Detailed Data Analysis to Follow Company to Hold Conference Call Today at 8:30 a.m. ET DURHAM, N.C., Dec. 28, 2015 -- (Healthcare Sales & Ma... BiopharmaceuticalsChimerix, brincidofovir, cytomegalovirus (Source: HSMN NewsFeed)



Atara Bio Announces Positive Results From a Phase 2 Clinical Trial of Cytomegalovirus Targeted Cytotoxic T Lymphocytes (CMV-CTL), a Novel Approach to Adoptive Immunotherapy, to Treat Patients With Refractory CMV Disease in the Central Nervous System (CNS)

Sun, 06 Dec 2015 15:21:19 +0100

(Source: Medical News (via PRIMEZONE))

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How cells are foiled by a herpesvirus family member in the virus-host arms race

Fri, 04 Dec 2015 23:36:24 +0100

Not every virus wants to go viral right away -- some want to wait for the perfect opportunity to attack. So the virus has to find a way to enter the cells of the human body without tripping the alarm. It's how viruses in the herpesvirus family, like human cytomegalovirus (HCMV), do their business. In a new study, researchers show that individual cells in the human body have an armament designed to prevent HCMV from achieving and maintaining this latency. (Source: ScienceDaily Headlines)



How Activists Changed The Federal Approach To AIDS Research Forever

Tue, 01 Dec 2015 11:00:13 +0100

When Dr. Anthony Fauci first became director of the National Institute of Allergies and Infectious Diseases in 1984, hundreds of people in the U.S. had already died from a mysterious and terrifying disease we now know to be HIV/AIDS. But even though the NIAID was in charge of finding treatments, vaccines and cures for communicable diseases, Fauci said his agency failed to act quickly enough in its search for effective medicines. The traditional research-to-pharmaceutical pipeline, of which Fauci remained staunchly in favor until a dramatic change of heart, took several years from start to finish -- and people with HIV and AIDS didn’t have years to wait. New experimental medicines weren't being shared with patients as soon as they were deemed safe; instead, they were held ba...



Transplant tourism increases health-related risks for organ recipients

Fri, 06 Nov 2015 18:29:18 +0100

Compared with recipients of living related kidney donor transplants, recipients who purchased organs internationally were more likely to develop hepatitis C, hepatitis B, and cytomegalovirus, and they were more likely to experience acute and recurrent rejections and surgical complications. Patient and organ survival rates were also lower in 'commercial' recipients. (Source: ScienceDaily Headlines)



Updates to the CMV (Herpes Virus) Section of the Adult OI Guidelines

Fri, 06 Nov 2015 00:00:00 +0100

This revision provides guidance for the management of cytomegalovirus (CMV) retinitis, which develops or worsens in the setting of ART initiation. Data supporting the treatment of CMV retinitis with systemic anti-CMV therapy for prevention of contralateral eye and visceral disease are discussed.   (Source: AIDSinfo At-a-Glance: Offering Information on HIV/AIDS Treatment, Prevention, and Research, A Service of the U.S. Department of Health and Human Services (DHHS))

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Monkey model discovery could spur CMV vaccine development

Mon, 19 Oct 2015 19:47:17 +0100

Rhesus monkeys can, in fact, transmit Cytomegalovirus (CMV) across the placenta to their unborn offspring, new research shows. This finding establishes the first primate model that researchers can use to study mother-to-fetus CMV infections and spur development of potential vaccine approaches. (Source: ScienceDaily Headlines)



Self-injurious behavior secondary to cytomegalovirus-induced neuropathy in an SIV-Infected Rhesus Macaque (Macaca mulatta) - Clemmons EA, Gumber S, Strobert E, Bloomsmith MA, Jean SM.

Sun, 12 Jul 2015 03:47:04 +0100

A 3.5-y-old, female rhesus macaque (Macaca mulatta) inoculated with SIVmac239 presented 8 mo later for inappetence and facial bruising. Physical examination revealed a superficial skin abrasion below the left eye, bruising below the left brow, and epistaxi... (Source: SafetyLit: All (Unduplicated))



Report warns of threat to unborn babies from CMV virus

Tue, 30 Jun 2015 12:00:00 +0100

"Thousands of pregnant women are unwittingly passing on infections to their unborn babies that cause severe disabilities," is the headline in the Daily Mail after a new report highlighted the risks cytomegalovirus (CMV) can pose to pregnancies. The paper says cytomegalovirus "can lie dormant in mother's body for years" and "is caught from other children through nappy changing and wiping mouths", so often older siblings can pass it on to unborn babies.  What is the basis for this report? The story was prompted by the release of a report by the charity CMV Action. The charity aims to raise awareness of the virus and campaign for better prevention measures within the health service. They also provide support for those affected by CMV.   What is CMV? CMV is...



Hot Atara snags licensing deal with cancer center

Mon, 15 Jun 2015 13:49:12 +0100

Experimental off-the-shelf cell therapies against cancer and long-term viral infections were grabbed by Atara Biotherapeutics Inc. in a licensing deal with Memorial Sloan Kettering Cancer Center. South San Francisco's Atara (NASDAQ: ATRA) — part of the San Francisco Business Times' life sciences IPO Class of 2014 — said Monday that it licensed three programs already in clinical trials that boost the body's ability to fight Epstein Barr Virus, or EBV, cytomegalovirus and Wilms Tumor 1, or WT1.… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

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Durham's Chimerix hits 'major milestone' in drug trial enrollment

Tue, 09 Jun 2015 13:25:52 +0100

Durham drug developer Chimerix, Inc. (Nasdaq: CMRX) reached a milestone by hitting full enrollment in a trial to test its lead drug against cytomegalovirus. Trial enrollment isn’t the most important news a drug developer can report, but it is significant because it puts the company back on track to test its experimental drug, called brincidofovir, in the correct patient population. In February, Chimerix disclosed it would take longer than initially anticipated to fully enroll the trial. Specifically,… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)



New therapy from naïve cells attacks high-risk viruses in cord blood transplant patients

Wed, 29 Apr 2015 04:00:00 +0100

(Baylor College of Medicine) Researchers in the Center for Cell and Gene Therapy at Baylor College of Medicine, Houston Methodist and the Texas Children's Hospital have expanded the use of virus-specific cell therapy in cord blood transplant patients to successfully prevent three of the most problematic post-transplant viruses affecting this group of patients that have yet to be addressed clinically -- cytomegalovirus, Epstein-Barr virus, and adenovirus. (Source: EurekAlert! - Cancer)



Cytomegalovirus and Inflammatory Bowel DiseaseCytomegalovirus and Inflammatory Bowel Disease

Mon, 20 Apr 2015 08:25:51 +0100

How common is cytomegalovirus in patients with IBD, how does it develop, and how is it best treated? Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)



Purging a virus from organ transplants

Tue, 07 Apr 2015 12:53:08 +0100

The switch that can awake a dormant cytomegalovirus, a dreadful pathogen in immuno-compromised patients, has been identified by scientists. The switch can be controlled with common drugs, opening a new strategy for purging the virus from organ transplants. (Source: ScienceDaily Headlines)



Perinatal Cytomegalovirus Infections: Epidemiology, Prevention, and Treatment

Wed, 01 Apr 2015 00:00:00 +0100

Mother-to-child transmission of cytomegalovirus (CMV) can lead to severe birth defects and neurologic impairment of infants. Congenital CMV is the most common congenital infection and the leading infectious cause of infant hearing loss and neurologic deficits, complicating up to 2% of all pregnancies globally. Although antiviral treatment of congenitally CMV-infected infants can ameliorate CMV-associated hearing loss and developmental delay, interventions that can effectively prevent congenital CMV infection and the associated neurologic impairments are still being evaluated. Moreover, an effective CMV vaccine to protect mothers against CMV acquisition during pregnancy is urgently needed to reduce the sizeable health and economic burden of this disease. Active and passive maternal and infa...



New Insights Into How Cytomegalovirus Infects Different Cell Types

Thu, 26 Mar 2015 11:58:02 +0100

(Source: News from NIGMS Funded Institutions)



Cytomegalovirus Hijacks Human Enzyme for Replication

Thu, 26 Mar 2015 11:58:02 +0100

(Source: News from NIGMS Funded Institutions)



Study announces a durable vaccine for Ebola

Wed, 25 Mar 2015 04:00:00 +0100

(University of Plymouth) A new study shows the durability of a novel 'disseminating' cytomegalovirus-based Ebola virus vaccine strategy that may eventually have the potential to reduce ebolavirus infection in wild African ape species. (Source: EurekAlert! - Infectious and Emerging Diseases)



Cytomegalovirus hijacks human enzyme for replication

Mon, 23 Mar 2015 04:00:00 +0100

(Princeton University) Researchers at Princeton have discovered that cytomegalovirus manipulates a process called fatty acid elongation, which makes the very-long-chain fatty acids necessary for virus replication. Published in the journal Cell Reports on March 3, the research team identified a specific human enzyme -- elongase enzyme 7 -- that the virus induces to turn on fatty acid elongation. (Source: EurekAlert! - Biology)

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