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MedWorm: Meningitis



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Meningitis category.



Last Build Date: Tue, 29 Mar 2016 16:31:15 +0100

 



Cryptococcal meningitis and beyond - Management of select opportunistic infections in Sub-Saharan Africa

Tue, 29 Mar 2016 09:23:41 +0100

Abstract: In sub-Saharan Africa, despite successful scale-up of ART programmes, opportunistic infections remain a frequent cause of morbidity, hospitalization and death. Factors that contributed to this are delays to HIV diagnosis, late engagement in ART care, difficulties with ART adherence and many patients not remaining engaged in care. Although tuberculosis is the most frequent HIV co-infection in the region, other opportunistic infections also result in considerable morbidity and mortality. (Source: International Journal of Infectious Diseases)

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Murine model of tuberculous meningitis: New insight into understanding pathological complications of the disease

Tue, 29 Mar 2016 09:23:40 +0100

Background: Tuberculous meningitis is most severe presentation of tuberculosis that causes mortality in one-third of the affected patients. Though an age old disease; it still remains an inefficiently treated infection of human brain. Main reason behind is less known pathophysiology of the disease which is due to limited studies in developing proper experimental model. (Source: International Journal of Infectious Diseases)



Leptospirosis

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: Leptospirosis is present worldwide and is especially important in developing countries, where sanitation is precarious. Sporadic cases are linked to contact with urine-contaminated water. In tropical countries, urban outbreaks can occur after floods in rainy season. Mild non-lethal anicteric forms comprise most cases and can be easily confused with flu, dengue fever, other mild viral illnesses and P. vivax malaria. About 5 to 10% of cases develop severe sepsis-like disease or meningitis during outbreaks. (Source: International Journal of Infectious Diseases)



Comparative evaluation of in-house Real time IS 6110, nested MPT 64 PCR and Roche AMPLICOR 16s rRNA PCR for diagnosing tuberculous meningitis

Tue, 29 Mar 2016 09:23:40 +0100

Background: Early diagnosis of tuberculous meningitis (TBM) is still a diagnostic challenge due to paucibacillary nature of the disease and conventional methods being quite insensitive and time consuming. We evaluated performance of three real time PCR assays targeting MPT64, IS6110 and 16s rRNA gene sequences for early diagnosis of TBM (Source: International Journal of Infectious Diseases)



Enterovirus encephalitis including Enterovirus 71 and D68

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: Enteroviruses are small RNA viruses that belong to several species groups (A to H and J) in the genus Enterovirus and family Piconarviridae. Central nervous system (CNS) involvement in enterovirus infections is well known although it is a relatively rare complication. Several neurological syndromes have been described including aseptic meningitis, acute flaccid paralysis (myelitis), and the more serious encephalitis. Perhaps the best known neurotropic enterovirus for more than a century is the poliovirus, although other enteroviruses have also been associated with neurological syndromes. (Source: International Journal of Infectious Diseases)



Clinical spectrum of Aeromonas infections in hospitalized patients

Tue, 29 Mar 2016 09:23:39 +0100

Background: The genus Aeromonas is a member of the family Vibrionaceae. Aeromonas hydrophila is the most commonly isolated species associated with human infections. Aeromonas species are gram negative,oxidase positive, non fermenting rods found in fresh water and are known to cause gastroenteritis, cellulitis, necrotizing fasciitis, meningitis, bacteremia and urinary tract infections. (Source: International Journal of Infectious Diseases)

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Meningococcal pneumonia in Japan: A case report and review of the literatures

Tue, 29 Mar 2016 09:23:39 +0100

Background: Although previous report showed that Neisseria meningitidis (N. meningitidis) was detected from oral cavity of healthy Japanese volunteers, pneumonia caused by this pathogen is very rare in Japan. Here, we present a case of non-invasive meningococcal pneumonia and review case reports in Japan. (Source: International Journal of Infectious Diseases)



Meningococcal carriage in University freshmen in Kashmir, North India

Tue, 29 Mar 2016 09:23:38 +0100

Background: Meningococcal disease is endemic in many parts of the world, with relatively large-scale outbreaks occurring in many countries. High density populations like dormitory students and military recruits are considered to be high risk groups to contract meningococcal disease. Indian data on meningococcal disease are sparse and limited to the studies undertaken during or immediately after suspected outbreaks. (Source: International Journal of Infectious Diseases)



Rare case of amphotericin-B resistant cryptococcal meningitis in HIV non reactive patient

Tue, 29 Mar 2016 09:23:38 +0100

Background: Cryptococcal meningitis is caused by cryptococcal neoformans and cryptococcal gatti. The incidence of cryptococcus meningitis has risen dramatically in past two decades especially in Eastern Africa and South-East asia due to HIV epidemic and increasing use of immunosuppresive drugs. Infection usually acquired through inhalational route causing primary pulmonary cryptococcosis with dissemination to extra pulmonary sites in immunocompromised. Commonly presents with fever, headache, altered sensorium and neck stiffness. (Source: International Journal of Infectious Diseases)



Policy options for state-based PCV rollout in India: The evidence base

Tue, 29 Mar 2016 09:23:38 +0100

Background: One in five child deaths occur in India; pneumonia and meningitis are major causes. Among Indian children aged 1-59 months, more than 160,000 deaths were attributed to pneumonia or meningitis in 2015. Pneumococcus is the most common cause of bacterial pneumonia, responsible for one-third of child pneumonia deaths. It is vaccine-preventable and more than 130 countries have introduced PCV into their national immunization programs. In these countries, routine PCV use has virtually eliminated vaccine-serotype pneumococcal pneumonia and invasive pneumococcal disease, and reduced severe pneumonia and all-cause mortality. (Source: International Journal of Infectious Diseases)



Clinical diversity in central nervous system cryptococcosis

Tue, 29 Mar 2016 09:23:37 +0100

Background: Though cryptococcal meningitis (CM) is recognized as a disease of the immunocompromised, studies have implicated that it also affect immunocompetent patients. (Source: International Journal of Infectious Diseases)

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Cryptococcus meningitis and the genotypes of cryptococcus neoformans prevalent in Western Maharashtra, India

Tue, 29 Mar 2016 09:23:37 +0100

Background: Cryptococcal meningitis is an AIDs defining illness. However the disease is seen in patients without HIV infection also. Attempts have been made to develop a vaccine for the disease, so the prevalent genotypes of Cryptococcal neoformans need to be identified. In the Indian scenario there is a paucity of literature on MLST genotyping. Genotyping of C. neoformans can be performed for epidemiological purpose, to determine whether the cryptococcosis is caused by single genotype or two or more genotypes and to develop vaccine production. (Source: International Journal of Infectious Diseases)



Thirty five years scenario of cryptococcal meningitis: An analysis in pre and post HIV era

Tue, 29 Mar 2016 09:23:37 +0100

Background: Cryptococcal meningitis remains one of the leading causes of morbidity and mortality among immunosuppressed individuals, particularly those with HIV infection. Globally, approximately one million cases occur each year resulting in more than six lakh deaths. (Source: International Journal of Infectious Diseases)



Hospital based sentinel surveillance of bacterial meningitis in India

Tue, 29 Mar 2016 09:23:37 +0100

Background: Pentavalent vaccine (a combination vaccine which protects against five killer diseases- diphtheria, pertussis, tetanus, hepatitis B and Haemophilus influenzae type B) is being introduced in various states of India as a part of Universal Immunization Programme. In this context it is critical to establish sentinel sites across India for surveillance of H.influenzae type B meningitis and use this opportunity also for surveillance of pneumococcal and meningococcal meningitis. Keeping this in mind a hospital-based sentinel surveillance network was established at 11 places across the country and this study reports the results of first three years of this surveillance program (Source: International Journal of Infectious Diseases)



Identification of etiologic agents in meningitis cases by multiplex real-time polymerase chain reaction and culture

Tue, 29 Mar 2016 09:23:37 +0100

Background: The etiological study of meningitis has traditionally been performed using bacterial cultures and more recently using polymerase chain reaction. The aim of this study was to determine the etiological agents that cause meningitis using both traditional culture techniques and molecular diagnostic methods to improve the laboratory diagnostic assessment of the patients. (Source: International Journal of Infectious Diseases)



Vitamin D deficiency, CNS inflammation, and clinical outcome in tubercular meningitis

Tue, 29 Mar 2016 09:23:36 +0100

Background: Tubercular (TB) meningitis results in high mortality (about 40%) and neurological sequelae despite early treatment with anti-TB drugs and dexamethasone. Hence, adjunctive treatments are needed to improve the outcome. Vitamin D deficiency is associated with poor treatment outcomes in pulmonary TB. But, its effect in patients with TB meningitis is unknown. We tested the hypothesis that low serum 25-OH vitamin D levels would be associated with poor clinical outcome in patients with TB meningitis. (Source: International Journal of Infectious Diseases)

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Five-year review of non-typhoidal salmonella meningitis in Cape Town, 2010 - 2015

Tue, 29 Mar 2016 09:23:36 +0100

We report three cases of NTS meningitis in paediatric patients in Cape Town (Note: two more cases have been identified). (Source: International Journal of Infectious Diseases)



An outbreak of 19 cases of Serratia marcescens meningitis after spinal anesthesia

Tue, 29 Mar 2016 09:23:36 +0100

Background: Bacterial meningitis is a rare but serious complication of spinal anesthesia (lower incidence of 4.5 cases per 100 000 spinal anesthesia), although individual cases have been reported in the literature, the occurrence of an epidemic remains an exceptional event. Serratia marcescens is an enteric bacterium that causes a variety of infections and nosocomial outbreaks including meningitis. She is mainly encountered in neonatology and neurosurgery. Our goal is to describe the epidemiological, clinical and evolutionary an outbreak of Serratia marcescens meningitis in a private clinic medical and surgical patients who received spinal anesthesia. (Source: International Journal of Infectious Diseases)



C-reactive protein levels help predict bacterial meningitis outcomes

Mon, 28 Mar 2016 19:13:53 +0100

Measuring C-reactive protein (CRP) levels in children with bacterial meningitis can help determine those children’s prognoses, a study showed. “A single CRP measurement on the 3rd or 4th day is the... (Source: Hospitalist News)



Model Karen Crespo who lost all four limbs to meningitis is a 'human mannequin'

Mon, 28 Mar 2016 11:54:58 +0100

Karen Crespo, 32, from Los Angeles, lost her arms and legs after meningitis ravaged her body but has gone on to become the first quadruple amputee model to walk down the runway at New York Fashion Week. (Source: the Mail online | Health)



Tuberculous meningitis: symptoms, diagnosis and evaluation experienced in 532 patients in a pediatric hospital

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions TM has continued to be a serious health problem in developing countries. Delay in diagnosis of this disease is a cause of the increase not only of its morbidity but also its mortality as well as its sequels. (Source: Asian Pacific Journal of Tropical Disease)



Differences Between Culture & Non-Culture Confirmed Invasive Meningococci with a Focus on Factor H-Binding Protein Distribution

Fri, 25 Mar 2016 23:00:00 +0100

To compare the distribution of capsular groups and Factor H-Binding Protein variants among meningococcal isolates and non-culture clinical specimens and to assess the representativeness of group B isolates amongst group B cases as a whole. (Source: Journal of Infection)



Sertraline improves Cryptococcus clearance in HIV meningitis

Fri, 25 Mar 2016 16:59:22 +0100

An open-label pilot study has found adjunct treatment with the SSRI antidepressant sertraline is associated with accelerated clearance of Cryptococcus from the cerebrospinal fluid in... (Source: Hospitalist News)



FDA Drug Safety Communication: Aseptic meningitis associated with use of Lamictal (lamotrigine)

Fri, 25 Mar 2016 14:23:00 +0100

[08-12-2010] The U.S. Food and Drug Administration (FDA) is informing the public that Lamictal (lamotrigine)†, a medication commonly used for seizures in children two years and older, and bipolar disorder in adults, can cause aseptic meningitis. (Source: FDA Center for Drug Evaluation and Research - What's New)



Tuberculosis Made Me Blind, But We Can Make Sure No One Else Needs to Suffer Like I Did

Thu, 24 Mar 2016 21:09:40 +0100

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Increased incidence of invasive meningococcal disease of serogroup C / clonal complex 11, Tuscany, Italy, 2015 to 2016

Thu, 24 Mar 2016 00:00:00 +0100

We report an increase of serogroup C Neisseria meningitidis invasive meningococcal disease in Tuscany. From January 2015 to end February 2016, 43 cases were reported, among which 10 were fatal, compared to two cases caused by serogroup C recorded in 2014 and three in 2013. No secondary cases occurred. Thirty-five strains belonged to C:P1.5-1,10-8:F3-6:ST-11(cc11). Control measures have been adopted and immunisation campaigns implemented. Studies on risk factors and carriage are ongoing. (Source: Eurosurveillance)

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Presentation with gastrointestinal symptoms and high case fatality associated with group W meningococcal disease (MenW) in teenagers, England, July 2015 to January 2016

Thu, 24 Mar 2016 00:00:00 +0100

Atypical clinical presentations associated with group W meningococcal disease (MenW) are well-described and include pneumonia, septic arthritis, endocarditis and epiglottitis/supraglottitis. Following anecdotal reports of teenagers presenting with predominantly gastrointestinal symptoms, we undertook a case review of MenW cases in 15 to 19 year-olds diagnosed in England between July 2015 and January 2016. Of the 15 cases, seven presented with a short history of nausea, vomiting and diarrhoea; five of these seven cases died within 24 hours of presentation to hospital. (Source: Eurosurveillance)



Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex

Wed, 23 Mar 2016 23:00:00 +0100

Klebsiella pneumoniae is a Gram-negative bacterium that is responsible for a range of common infections, including pulmonary pneumonia, bloodstream infections and meningitis. Certain strains of Klebsiella have become highly resistant to antibiotics. Despite the vast amount of research carried out on this class of bacteria, the molecular structure of its topoisomerase IV, a type II topoisomerase essential for catalysing chromosomal segregation, had remained unknown. In this paper, the structure of its DNA-cleavage complex is reported at 3.35 Å resolution. The complex is comprised of ParC breakage-reunion and ParE TOPRIM domains of K. pneumoniae topoisomerase IV with DNA stabilized by levofloxacin, a broad-spectrum fluoroquinolone antimicrobial agent. This complex is compared with a simil...



Student spent weeks in coma and woke up paralysed after mistaking meningitis for freshers' flu

Wed, 23 Mar 2016 13:47:00 +0100

Jemma Pressman, 19, of Eastleigh, Hampshire, thought her grogginess and stiff neck were signs of flu - but she actually had meningitis which was ravaging her body, causing brain damage. (Source: the Mail online | Health)



Pharyngeal carriage of Neisseria species in the African meningitis belt

Tue, 22 Mar 2016 23:00:00 +0100

Neisseria meningitidis, together with the non-pathogenic Neisseria species (NPNs), are members of the complex microbiota of the human pharynx. This paper investigates the influence of NPNs on the epidemiology of meningococcal infection. (Source: Journal of Infection)



Pharyngeal carriage of Neisseria species in the African meningitis belt

Tue, 22 Mar 2016 23:00:00 +0100

Neisseria meningitidis, together with the non-pathogenic Neisseria species (NPNs), are members of the complex microbiota of the human pharynx. This paper investigates the influence of NPNs on the epidemiology of meningococcal infection. (Source: Journal of Infection)

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Meningitis B vaccine IS worth the cost, experts tell health committee

Tue, 22 Mar 2016 20:54:45 +0100

Vinny Smith, of the Meningitis Research Foundation, told MPs meningitis is a ‘fiendishly difficult’ disease to detect. The petition for a vaccine became the most-signed in Downing Street history. (Source: the Mail online | Health)



Meningitis B vaccine cost analysis 'underestimates' impact on families

Tue, 22 Mar 2016 20:38:31 +0100

Campaigners and experts calling for older children to receive MenB vaccine say current cost-benefit analysis does not take into account the true impacts of the illness (Source: Telegraph Health)



Cerebrospinal fluid ferritin and albumin index: potential candidates for scoring system to differentiate between bacterial and viral meningitis in children.

Tue, 22 Mar 2016 19:02:02 +0100

Authors: Jebamalar AA, Balakrishnapillai AK, Parmeswaran N, Dhiman P, Rajendiran S Abstract OBJECTIVES: To evaluate the diagnostic role of cerebrospinal fluid (CSF) ferritin and albumin index (AI = CSF albumin/serum albumin × 1000) in differentiating acute bacterial meningitis (ABM) from acute viral meningitis (AVM) in children. METHODS: The study included 42 cases each of ABM and AVM in pediatric age group. Receiver operating characteristic (ROC) analysis was carried out for CSF ferritin and AI. Binary logistic regression was also done. RESULTS: CSF ferritin and AI were found significantly higher in ABM compared to AVM. Model obtained using AI and CSF ferritin along with conventional criteria is better than existing models. PMID: 26999689 [PubMed - as supplied...



[Editorial] Costs, compassion, and the case for vaccination

Tue, 22 Mar 2016 08:07:51 +0100

If you want an overview of the major political issues in the UK, the government's petitioning website is a good place to start. Calls for action on Islamic State, immigration, and the National Health Service (NHS) have all garnered hundreds of thousands of signatures. But the most popular current petition—indeed, the issue that has received the most signatures ever on the site—concerns meningitis B vaccination. (Source: The Lancet Infectious Diseases)



[Comment] Control of meningitis outbreaks in the African meningitis belt

Tue, 22 Mar 2016 08:07:51 +0100

The development and deployment of serogroup A meningococcal conjugate vaccine (MenAfriVac) in several countries within the meningitis belt of west Africa brought hope for the eradication of the disease in this region. Progress was set back, however, by the outbreak of serogroup C disease during the dry season of 2014–15 in Niger, with more than 8500 cases and 550 deaths.1 The last major outbreaks of serogroup C disease occurred in Burkina Faso in 1979 and, more recently, sequential outbreaks in 2013 and 2014 occurred in northwest Nigeria2 caused by sequence type (ST)-10217, which has not been previously identified elsewhere. (Source: The Lancet Infectious Diseases)

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Astrovirus MLB2, a New Gastroenteric Virus Associated with Meningitis and Disseminated Infection

Tue, 22 Mar 2016 04:00:00 +0100

S. Cordey et al. (Source: Emerging Infectious Diseases Journal)



The impact of meningitis vaccines and their future role

Mon, 21 Mar 2016 23:00:00 +0100

The success of the meningococcal group A (MenA) vaccination in the African meningitis belt, public support for the extension of the MenB vaccination in the UK and the importance of vaccination in the fight against antimicrobial resistance all endorse the need for additional meningitis vaccines in the future. (Source: Prescriber)



Terminal Complement Inhibitor Eculizumab in Adult Patients With Atypical Hemolytic Uremic Syndrome: A Single-Arm, Open-Label Trial

Mon, 21 Mar 2016 23:00:00 +0100

Conclusions Results highlight the benefits of eculizumab in adult patients with aHUS: improvement in hematologic, renal, and quality-of-life parameters; dialysis discontinuation; and transplant protection. (Source: American Journal of Kidney Diseases)



Simultaneous cryptococcal and tuberculous meningitis in a patient with systemic lupus erythematosus

Mon, 21 Mar 2016 23:00:00 +0100

We describe a patient with systemic lupus erythematosus diagnosed with simultaneous cryptococcal and TB meningitis who had a poor response to intravenous liposomal amphotericin B and fluconazole, but was successfully treated with intraventricular amphotericin B, in addition to anti-TB therapy. (Source: Journal of Microbiology, Immunology and Infection)



Carrier priming effect of CRM197 is related to an enhanced B and T cell activation in meningococcal serogroup A conjugate vaccination. Immunological comparison between CRM197 and diphtheria toxoid.

Mon, 21 Mar 2016 23:00:00 +0100

Authors: Pecetta S, Tontini M, Faenzi E, Cioncada R, Proietti D, Seubert A, Nuti S, Berti F, Romano MR Abstract Glycoconjugate vaccines are composed of capsular polysaccharides (CPSs) of a pathogenic bacteria covalently linked to carrier proteins. Pre-exposure to the carrier is known to influence the efficacy of the glycoconjugate, by inducing enhanced or suppressed anti-CPS response. Following our previous work on the immunogenicity of diphtheria toxin mutant CRM197 and formaldehyde-treated diphtheria toxoid (DT) as carriers for meningococcal A (MenA) conjugates in mouse model, we further investigated the role of the carrier on the immunological response to glycoconjugate vaccines. We previously showed that high dosage DT priming could result in carrier-induced epitopic suppressio...

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Meningitis-retention Syndrome; A Case Report

Mon, 21 Mar 2016 00:00:00 +0100

We report a case of meningitis-retention syndrome followed by urodynamic tests. A 48-year-old man was admitted to the hospital for an undiagnosed fever with headache and urinary retention. Aseptic meningitis was suspected according to cerebrospinal fluid analyses, and urodynamic test showed an underactive detrusor, leading to inadequate contraction of the bladder on voiding in spite of a normal sensation during bladder filling. Clean intermittent self-catheterization was required temporarily, but normal urinary voiding without the need for medication was restored in 2 weeks after discharge from the hospital, when urodynamic tests showed normal contractility of the bladder during voiding. (Source: Urology Case Reports)



[Endoscopic endonasal surgery for sellar region pathology. An analysis of our first 200 patients. What we have learned].

Sun, 20 Mar 2016 23:00:00 +0100

CONCLUSION: The results obtained in our series, due to the centralisation of pathology and experience, are comparable to those achieved in pituitary surgery reference centres. Early surgical exploration of cerebrospinal fluid leaks reduces the risk of post-surgical meningitis. PMID: 27012678 [PubMed - as supplied by publisher] (Source: Neurocirugia)



Influence of population diversity on neurovirulence potential of plaque purified L-Zagreb variants.

Sun, 20 Mar 2016 23:00:00 +0100

CONCLUSIONS: Distinctive heterogeneity profiles were obtained for insufficiently neuroattenuated L-Zagreb variants. No markers that would discriminate between marginally and well neuroattenuated variants were identified. The findings of this study may serve as a guideline during development of an improved L3/L-Zagreb vaccine strain. PMID: 27013432 [PubMed - as supplied by publisher] (Source: Vaccine)



Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry as a First-Line Diagnostic Modality in Bacterial Meningitis and Septicemia: a Report of Five Cases

Sat, 19 Mar 2016 17:07:36 +0100

The matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) technology has been shown to be a cost-effective, efficient, and reliable system for performing bacterial identifications. It has a number of potential advantages in clinical care. Here, we describe five life-threatening infections caused by either Listeria monocytogenes or Neisseria meningitidis that were diagnosed by using the MALDI-TOF MS system. The system proved particularly useful when the Gram-stained-smear results were misleading or inconclusive. (Source: Clinical Microbiology Newsletter)



Spontaneous Transethmoidal Meningoceles in Adults: Case Series with Emphasis on Surgical Management.

Sat, 19 Mar 2016 14:41:02 +0100

Conclusion. Spontaneous transethmoidal meningocele in adults is a rare condition. It usually presents with clear rhinorrhea with or without meningitis and an endoscopic multilayer reconstruction is advocated for treatment of such conditions. PMID: 26989762 [PubMed - in process] (Source: The Scientific World Journal)

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Meningococcemia in Adults: A Review of the Literature.

Fri, 18 Mar 2016 23:15:02 +0100

Authors: Takada S, Fujiwara S, Inoue T, Kataoka Y, Hadano Y, Matsumoto K, Morino K, Shimizu T Abstract We mainly refer to the acute setting of meningococcemia. Meningococcemia is an infection caused by Neisseria meningitidis, which has 13 clinically significant serogroups that are distinguishable by the structure of their capsular polysaccharides. N. meningitidis, also called meningococcus, is a Gram-negative, aerobic, diplococcus bacterium. The various consequences of severe meningococcal sepsis include hypotension, disseminated intravascular coagulation (DIC), multiple organ failure, and osteonecrosis due to DIC. The gold standard for the identification of meningococcal infection is the bacteriologic isolation of N. meningitidis from body fluids such as blood, cerebrospinal fluid...



Meningitis B row shows flaws in how vaccine decisions are made

Fri, 18 Mar 2016 18:16:35 +0100

We can only make good healthcare decisions with good evidence to base them on. In the case of the meningitis vaccine, the advice may be flawed, says Clare Wilson (Source: New Scientist - Health)



Neisseria meningitidis Serogroup X in Sub-Saharan Africa.

Fri, 18 Mar 2016 15:37:03 +0100

Authors: Agnememel A, Hong E, Giorgini D, Nuñez-Samudio V, Deghmane AE, Taha MK Abstract The epidemiology of meningococcal disease varies by geography and time. Whole-genome sequencing of Neisseria meningitidis serogroup X isolates from sub-Saharan Africa and Europe showed that serogroup X emergence in sub-Saharan Africa resulted from expansion of particular variants within clonal complex 181. Virulence of these isolates in experimental mouse models was high. PMID: 26982628 [PubMed - in process] (Source: Emerging Infectious Diseases)



Trial for Alberta parents whose toddler died from meningitis resumes after lawyers' dispute

Fri, 18 Mar 2016 15:25:42 +0100

The trial of parents charged in their young son's death will resume today in Lethbridge after it was abruptly adjourned Thursday over a dispute between the Crown and defence counsel. (Source: CBC | Health)



Relapsing polychondritis and lymphocytic meningitis with varied neurological symptoms

Fri, 18 Mar 2016 00:00:00 +0100

Conclusion Relapsing polychondritis is a challenging disease that can rarely manifest with varied neurological symptoms; recognition is extremely important, because high-dose corticosteroids should be used as soon as possible in suspected cases. (Source: Revista Brasileira de Reumatologia)

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An Algorithm for Surgical Approach to the Anterior Skull Base

Fri, 18 Mar 2016 00:00:00 +0100

Conclusion Sinonasal and skull base malignancies can be safely surgically addressed via several approaches. Surgical approach should be selected algorithmically based on preoperative clinical assessment of the tumor and known postoperative complication rates.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)



Epidemiological impact and cost-effectiveness of introducing vaccination against serogroup B meningococcal disease in France.

Thu, 17 Mar 2016 23:00:00 +0100

CONCLUSIONS: Given current meningococcal epidemiology in France and the available data on the protection provided by Bexsero(®), our modelling work showed that routine vaccination against serogroup B meningococcal disease is not cost-effective. PMID: 27002504 [PubMed - as supplied by publisher] (Source: Vaccine)



Infection by the Nematode Angiostrongylus cantonensis Induces Differential Expression of miRNAs in Mouse Brain

Thu, 17 Mar 2016 00:00:00 +0100

Conclusion This study suggested a critical role of miRNAs in the host defense during A. cantonensis infection, providing new insights into the molecular mechanisms underlying the interaction between mmu-miR-146a-5p and TNF-α in angiostrongyliasis in non-permissive hosts. (Source: Journal of Microbiology, Immunology and Infection)



Chiari I malformation

Thu, 17 Mar 2016 00:00:00 +0100

A 6-year-old boy was investigated for persistent headaches, frequently accompanied by photophobia and vomiting. He had been sent home from school several times over the past 4 months, and had recently been admitted to hospital with an exacerbation of the headaches. On that occasion meningitis was excluded. There were no abnormal neurological signs on examination. An MR scan was arranged as an outpatient which showed a Chiari I malformation. Look at the midline T1-weighted image from his cranial MR scan (figure 1), and answer the following questions. Read on to confirm the answers and learn more about this condition. Questions The cerebellar tonsils are herniated below the foramen magnum. True or false? Cerebrospinal fluid (CSF) spaces at the craniocervical junction are normal in size....



Cytomegalovirus Meningitis in an Infant with Severe Combined Immunodeficiency

Thu, 17 Mar 2016 00:00:00 +0100

A 35-day-old female with severe combined immunodeficiency developed cytomegalovirus (CMV) meningitis before undergoing hematopoietic stem cell transplantation. Strategies for timely diagnosis of neonates with congenital or acquired CMV infection and prevention of CMV acquisition in the era of universal newborn severe combined immunodeficiency screening are needed. (Source: The Journal of Pediatrics)

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Injection Site Lichenoid Dermatitis Following Pneumococcal Vaccination: Report and Review of Cutaneous Conditions Occurring at Vaccination Sites

Wed, 16 Mar 2016 23:00:00 +0100

Conclusions Dermatoses at the injection sites of vaccines can be granulomatous, immunity-related conditions, infections, lichenoid, neutrophilic, or pseudolymphomatous. Basal cell carcinoma and squamous cell carcinoma are the most common vaccination site-associated malignancies; however, melanoma and sarcomas (dermatofibrosarcoma protuberans, fibrosarcoma, and malignant fibrous histiocytoma) are also smallpox vaccine-related site neoplasms. A cutaneous immunocompromised district that is created by vaccine-induced local immunologic changes is hypothesized to be the pathogenesis of vaccination site reactions. (Source: Dermatology and Therapy)






Join our London run in support of Meningitis research.

Wed, 16 Mar 2016 00:00:00 +0100

Authors: Reed L Abstract Runners wishing to be part of Meningitis Now's team at this year's Royal Parks Foundation Half Marathon need to get their skates on to secure one of our guaranteed places. PMID: 26982863 [PubMed - in process] (Source: Nursing Standard)



Enterovirus-related diarrhoea in Guangdong, China: clinical features and implications in hand, foot and mouth disease and herpangina

Wed, 16 Mar 2016 00:00:00 +0100

A series of complications caused by enteroviruses, including meningitis, encephalitis, acute flaccid paralysis, acute cardiopulmonary failure, respiratory infection, and myocardial injury have been reported in... (Source: BMC Infectious Diseases)



Parents of meningitis toddler faye burdett say they were 'pushed aside'

Tue, 15 Mar 2016 20:05:57 +0100

Two-year-old Faye Burdett's parents spoke to MPs today after shocking images of the tragic toddler helped the petition become the most signed in Downing Street history. (Source: the Mail online | Health)

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'Doctors are too afraid to mention meningitis' parents warn

Tue, 15 Mar 2016 16:33:47 +0100

Families call for better awareness of meningitis B symptoms and call for quicker precautionary action to be taken by medics (Source: Telegraph Health)



Matt Dawson tells MPs of son's battle with meningitis

Tue, 15 Mar 2016 16:09:53 +0100

Campaigners behind the meningitis B vaccine petition, including former England rugby player Matt Dawson, ask MPs to consider vaccinating all children up to the age of 11 (Source: Telegraph Health)



Meningitis B vaccine 'not too costly'

Tue, 15 Mar 2016 15:15:53 +0100

Parents tell MPs that the cost of giving the meningitis B vaccine to more UK children would be justifiable and save lives. (Source: BBC News | Health | UK Edition)



VIDEO: Mother's plea for routine Men B jabs

Tue, 15 Mar 2016 00:11:36 +0100

Parents are to tell MPs why they think the Meningitis B vaccine should be given to all UK children up to the age of 11. (Source: BBC News | Health | UK Edition)



Streptococcus suis in invasive human infections in Poland: clonality and determinants of virulence and antimicrobial resistance

Tue, 15 Mar 2016 00:00:00 +0100

Abstract The purpose of this study was to perform an analysis of Streptococcus suis human invasive isolates, collected in Poland by the National Reference Centre for Bacterial Meningitis. Isolates obtained from 21 patients during 2000–2013 were investigated by phenotypic tests, multilocus sequence typing (MLST), analysis of the TR9 locus from the multilocus variable number tandem repeat (VNTR) analysis (MLVA) scheme and pulsed-field gel electrophoresis (PFGE) of SmaI-digested DNA. Determinants of virulence and antimicrobial resistance were detected by polymerase chain reaction (PCR) and analysed by sequencing. All isolates represented sequence type 1 (ST1) and were suggested to be serotype 2. PFGE and analysis of the TR9 locus allowed the discrimination of four and 17 types, res...

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Purification of mumps virus particles of high viability.

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Chen H, Ngo L, Petrovskaya S, Gao Y, Laassri M, Rubin S Abstract Mumps is a highly infectious viral disease of humans with a wide array of clinical manifestations ranging from painful swelling of the salivary glands to meningitis and encephalitis. Despite the clinical importance of mumps virus, most of what is known of its biological properties comes from studies using supernatants from virus infected cell cultures, which contain substantial levels of host cell derived debris and biologically active substances such as cytokines, transcription factors and secreted virus proteins. These contaminants complicate interpretation of studies of virus replication, virus-host interactions and in vivo virulence. Here we describe a protocol for concentration of the virus from cell cul...



Comment on the letter to the editor concerning manuscript:“Therapeutic hypothermia for adult community-acquired bacterial meningitis-historical control study”

Mon, 14 Mar 2016 00:00:00 +0100

We read the comment on our manuscript “Therapeutic hypothermia for adult community-acquired bacterial meningitis −historical control study” with particulair interest. (Source: Clinical Neurology and Neurosurgery)



Status of vaccine research and development of vaccines for GBS.

Mon, 14 Mar 2016 00:00:00 +0100

Authors: Heath PT Abstract Streptococcus agalactiae (group B streptococcus (GBS)) is the leading cause of neonatal sepsis and meningitis in many countries. Intrapartum antibiotic strategies have reduced the incidence of early-onset neonatal GBS in a number of countries but have had no impact on late onset GBS infection (LOD). In low/middle income settings, the disease burden remains uncertain although in several countries of Southern Africa appears comparable to or higher than that of high-income countries. As disease may be rapidly fulminating cases can be missed before appropriate samples are obtained and this may lead to underestimation of the true burden. Given the rapid onset and progression within hours of birth as well as the deficiencies in IAP strategies and absence of a s...



Comment on the letter to the editor concerning manuscript: “Therapeutic hypothermia for adult community-acquired bacterial meningitis-historical control study”

Mon, 14 Mar 2016 00:00:00 +0100

We read the comment on our manuscript “Therapeutic hypothermia for adult community-acquired bacterial meningitis—historical control study” with particulair interest. (Source: Clinical Neurology and Neurosurgery)



The Burden of Pediatric Invasive Meningococcal Disease in Spain (2008–2013)

Sat, 12 Mar 2016 19:07:26 +0100

Conclusions: Serogroup B invasive meningococcal infection explains substantial morbidity and mortality in Spain, occurring mainly in infants. The recent availability of a vaccine against serogroup B may change this scenario. Given that the vast majority of the cases occur in otherwise healthy children, inclusion of the meningococcal B vaccine in the national immunization program should be carefully considered. (Source: The Pediatric Infectious Disease Journal)

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Persistence of Bactericidal Antibodies After Infant Serogroup B Meningococcal Immunization and Booster Dose Response at 12, 18 or 24 Months of Age

Sat, 12 Mar 2016 19:07:26 +0100

Conclusions: A 4CMenB booster-dose can overcome waning hSBA titers after early-infant immunization. Administration at 12 months could help to maintain immunity during an age of high risk, and the persistence of this response requires further study. (Source: The Pediatric Infectious Disease Journal)



Extra pulmonary tuberculosis presenting as fever with massive splenomegaly and pancytopenia

Sat, 12 Mar 2016 00:00:00 +0100

We report the case of a 13-year old male who presented with fever, weight loss, pallor and massive splenomegaly with pancytopenia, in whom a bone marrow trephine biopsy showed caseating granulomata, who responded well to antituberculous treatment and has remained healthy on follow up after nine years. (Source: IDCases)



Reasons and results of endoscopic surgery for prolactinomas: 142 surgical cases

Sat, 12 Mar 2016 00:00:00 +0100

Conclusions Our series together with literature data suggest that an endoscopic endonasal trans-sphenoidal approach in the treatment of proloctinomas has a favourable rate of remission. According to the findings of this study, endoscopic endonasal trans-sphenoidal surgery might be an appropriate therapy choice for patients with prolactinoma who could not have been managed with recommended therapeutic modalities. (Source: Acta Neurochirurgica)



A Tragedy Leads To Scrutiny Of 'Natural' Treatments In Canada

Fri, 11 Mar 2016 18:51:00 +0100

Ezekiel Stephan died from meningitis. He was 19 months old when after many days of suffering, he stopped breathing. His parents are now on trial in Canada for failing to get him the professional medical help that might have saved his life. (Source: Forbes.com Healthcare News)



Errata: Vol. 65, No. 6.

Fri, 11 Mar 2016 14:54:02 +0100

Authors: Abstract In the report, "Notes from the Field: Administration Error Involving a Meningococcal Conjugate Vaccine - United States, March 1, 2010-September 22, 2015," on page 162, the end of the first paragraph should contain an additional sentence as follows: "However, because serogroup A meningococcal disease is rare in the United States, patients only receiving the liquid MenCYW-135 component of Menveo might not need revaccination, unless international travel is anticipated (especially travel to Africa) (3,6)." PMID: 26963773 [PubMed - as supplied by publisher] (Source: MMWR Morb Mortal Wkl...)

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Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015.

Fri, 11 Mar 2016 14:54:02 +0100

Authors: Talley P, Holzbauer S, Smith K, Pomputius W Abstract On April 20, 2015, a female aged 15 years sought care at her pediatrician's office after 5 days of fever, myalgia, left parietal headache, and photophobia. A rapid influenza assay was negative, and erythrocyte sedimentation rate and total white blood cell count were normal. She improved with symptomatic care at home, but returned to her pediatrician's office on April 28, reporting recurrence of her headache and photophobia and new onset of a stiff neck. She was admitted to the hospital, where she was febrile to 102.9°F (39.4°C) and had meningismus. Computed tomography scan of her head was normal, and a cerebrospinal fluid (CSF) analysis showed a markedly elevated white blood cell count with 68% lymphocytes, low glucose...



Diagnostic accuracy of interferon-gamma release assays for tuberculous meningitis: a meta-analysis

Fri, 11 Mar 2016 12:35:51 +0100

(Source: International Journal of Tuberculosis and Lung Disease)



Endoscopic endonasal multilayer repair of traumatic CSF rhinorrhea

Fri, 11 Mar 2016 04:34:10 +0100

The objective of this study is to present our experience in management of traumatic CSF leaks using the endoscopic multilayer repair technique. Forty-two patients (aged 10–75 years, 30 males and 12 females) presenting with confirmed post-traumatic CSF rhinorrhea were operated upon between January 2007 and December 2013. The endoscopic multilayer technique was used in all cases. Electromagnetic navigation was used in some cases. All cases presented with intermittent watery rhinorrhea. The duration of the rhinorrhea ranged from 3 days to 1 year before repair. One case presented after 10 years from the causative trauma. Ten cases had a history of meningitis. Nine cases had more than one defect. Iatrogenic defects were larger than defects following accidental trauma. Two cases, following RT...



Leptomeningeal carcinomatosis as primary manifestation of pancreatic cancer

Fri, 11 Mar 2016 00:00:00 +0100

We present an uncommon case of LMC secondary to pancreatic carcinoma presenting with headache, unilateral VII nerve palsy, and lower extremity weakness. Initial cerebrospinal fluid (CSF) studies were concerning for chronic aseptic meningitis but negative for malignant cells; the diagnosis of tuberculous meningitis was erroneously evoked. Three lumbar punctures were required to capture malignant cells. The diagnosis of LMC was based on CSF examination with cytology/immunohistochemistry and leptomeningeal enhancement on MRI. Post mortem autopsy revealed advanced and diffusely metastatic pancreatic adenocarcinoma. This patient demonstrates that solid tumors can present with leptomeningeal spread that often confuses the treating physician. Fungal or tuberculous meningitis can mimic LMC in the ...



Necrotizing Cellulitis With Multiple Abscesses on the Leg Caused by Serratia marcescens

Thu, 10 Mar 2016 05:00:00 +0100

A gram-negative bacillus of the Enterobacteriaceae family, Serratia marcescens is an organism known to cause bacteremia, pneumonia, urinary tract infection, endocarditis, meningitis, and... (Source: Cutis: Cutaneous Medicine for the Practitioner)

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Parent of toddler who died of meningitis asked Alberta naturopath for immune system boost

Thu, 10 Mar 2016 02:28:12 +0100

An employee at a southern Alberta naturopathic clinic says the mother of a gravely ill toddler asked for an immune system boost because she feared her son had viral meningitis. (Source: CBC | Health)



Atypical leptospirosis: an overlooked cause of aseptic meningitis

Thu, 10 Mar 2016 00:00:00 +0100

Leptospirosis, probably the most common zoonosis in the world, is caused by pathogenic Leptospira species. Clinical presentations range from nonspecific fevers to fulminant diseases such as Weil’s syndrome. Neuro... (Source: BMC Research Notes)



Funding and Innovation in Diseases of Neglected Populations: The Paradox of Cryptococcal Meningitis

Thu, 10 Mar 2016 00:00:00 +0100

(Source: PLoS Neglected Tropical Diseases)



The relationship between prior antimicrobial prescription and meningitis: a case-control study.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSION: There was an increased risk of meningitis following antimicrobial prescription in the previous year. It is possible that this increase was due to an effect of antimicrobials on the microbiome or reflected an increased general susceptibility to infections in these patients. PMID: 26965030 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)



[Multiple facial nodules revealing disseminated cryptococcosis in an immunocompetent patient].

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSION: Although rare, cryptococcosis can occur in immunocompetent subjects. The prognosis is severe even after treatment. PMID: 26971369 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

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Status of vaccine research and development of vaccines for herpes simplex virus prepared for WHO PD-VAC.

Thu, 10 Mar 2016 00:00:00 +0100

Authors: Johnston C, Gottlieb SL, Wald A Abstract Herpes simplex virus type-1 (HSV-1) and -2 (HSV-2) are highly prevalent global pathogens which commonly cause recurrent oral and genital ulcerations. Less common but more serious complications include meningitis, encephalitis, neonatal infection, and keratitis. HSV-2 infection is a significant driver of the HIV epidemic, increasing the risk of HIV acquisition 3 fold. As current control strategies for genital HSV-2 infection, including antiviral therapy and condom use, are only partially effective, vaccines will be required to reduce infection. Both preventive and therapeutic vaccines for HSV-2 are being pursued and are in various stages of development. We will provide an overview of efforts to develop HSV-2 vaccines, including a dis...



Phase I study of IMGN901, a CD56-targeting antibody-drug conjugate, in patients with CD56-positive solid tumors

Wed, 09 Mar 2016 00:00:00 +0100

Conclusions The RP2D for IMGN901 of 60 mg/m2 administered for 3 consecutive days every 3 weeks was associated with an acceptable tolerability profile. Objective responses were observed in patients with advanced CD56+ cancers. (Source: Investigational New Drugs)



Meningococcal vaccination for international travellers from Greece visiting developing countries

Wed, 09 Mar 2016 00:00:00 +0100

Meningococcal meningitis is a serious disease. Travel-associated infection for the general traveller is low; however regular epidemics in indigenous population, particularly in sub-Saharan Africa are responsible for significant morbidity and mortality. Our aim was to assess meningococcal vaccination for international travellers from Greece. (Source: Travel Medicine and Infectious Disease)



[Tuberculous meningitis in children in Dakar].

Wed, 09 Mar 2016 00:00:00 +0100

Authors: Thiongane A, Ba ID, Faye PM, Sylla A PMID: 26971138 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)



No extra benefit from infancy booster of MenACWY-TT

Tue, 08 Mar 2016 21:25:43 +0100

Receiving two doses of a combination tetanus and meningococcal vaccine in infancy did not result in additional protection among children 5 years later, a study found. Researchers followed up on... (Source: Pediatric News)

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Antibody-induced neutrophil depletion prior to the onset of pneumococcal meningitis influences long-term neurological complications in mice

Tue, 08 Mar 2016 00:00:00 +0100

Publication date: Available online 7 March 2016 Source:Brain, Behavior, and Immunity Author(s): Lay Khoon Too, Andrew J. Mitchell, Iain S. McGregor, Nicholas H. Hunt During pneumococcal meningitis, clearance of bacteria by recruited neutrophils is crucial for host protection. However, these innate immune mechanisms are often insufficient and treatment with antibiotics is necessary to prevent death. Despite this antibiotic treatment, approximately half of all survivors suffer lifelong neurological problems. There is growing evidence indicating the harmful effects of neutrophils on CNS integrity. Therefore, the present study investigated the roles of neutrophils in the acute inflammatory response and the resulting long-term neuropsychological effects in murine pneumococcal meningitis. ...



Surgical techniques in radiation induced temporal lobe necrosis in nasopharyngeal carcinoma patients

Tue, 08 Mar 2016 00:00:00 +0100

Conclusion Neurosurgical intervention through a temporal approach with linear incision is warranted in patients with radiation induced temporal lobe necrosis with significant symptoms and signs of increased intracranial pressure, minimum space occupying effect on imaging, or neurological deterioration despite conservative management. (Source: Polish Journal of Neurology and Neurosurgery)



Molecular characterization of echovirus 30 isolates from Poland, 1995–2015

Tue, 08 Mar 2016 00:00:00 +0100

Abstract Echovirus 30 (E30) is one of the most frequently identified enterovirus and a major cause of meningitis in children and adults. To investigate the genetic variability and relationship of E30 isolated from specimens of aseptic meningitis cases that occurred in Poland over a period of 20 years, sequences of VP1 gene were determined and genetic analysis was performed. From 1995 to 2015, 124 E30 were isolated using RD cells, and 58 isolates were sequenced and characterized by phylogenetic analysis of partial VP1 region (793 nt). In general, nucleotide sequence divergence in pairwise comparisons among Polish E30 isolates ranged from 0.0 to 15.0 %. The phylogenetic analysis revealed that E30 circulating in Poland since 1995 belong to two unique groups: Group I, characterized ...



Improving modern vaccines: Sugar polymer tails wag the protein dog

Mon, 07 Mar 2016 17:55:48 +0100

Millions of people – particularly infants in underdeveloped countries – suffer from the serious life threatening illnesses of meningitis, pneumonia and influenza. Early vaccines were based on the large and complex carbohydrate (sugar) based polymers produced by the bacteria. More recently new glycoconjugate vaccines have been developed which involves ‘fusing’ the complex carbohydrates – the sugar polymer tails - onto carrier proteins. These sugar-protein complexes improve the effectiveness and longevity of the vaccine. However, there are still problems concerning the stability of formulations they are prepared in, warn researchers. (Source: ScienceDaily Headlines)



Antibody-induced neutrophil depletion prior to the onset of pneumococcal meningitis influences long-term neurological complications in mice.

Mon, 07 Mar 2016 00:00:00 +0100

Authors: Too LK, Mitchell AJ, McGregor IS, Hunt NH Abstract During pneumococcal meningitis, clearance of bacteria by recruited neutrophils is crucial for host protection. However, these innate immune mechanisms are often insufficient and treatment with antibiotics is necessary to prevent death. Despite this antibiotic treatment, approximately half of all survivors suffer lifelong neurological problems. There is growing evidence indicating the harmful effects of neutrophils on CNS integrity. Therefore, the present study investigated the roles of neutrophils in the acute inflammatory response and the resulting long-term neuropsychological effects in murine pneumococcal meningitis. Long-term behavioural and cognitive functions in mice were measured using an automated IntelliCage syste...

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Klebsiella pneumoniae invasive liver abscess syndrome with purulent meningitis and septic shock: A case from mainland China.

Mon, 07 Mar 2016 00:00:00 +0100

We present a rare case of invasive liver abscess syndrome due to Klebsiella pneumoniae (K. pneumoniae) with metastatic meningitis and septic shock. A previously healthy, 55-year-old female patient developed fever, liver abscess, septic shock, purulent meningitis and metastatic hydrocephalus. Upon admission, the clinical manifestations, laboratory and imaging examinations were compatible with a diagnosis of K. pneumoniae primary liver abscess. Her distal metastasis infection involved meningitis and hydrocephalus, which could flare abruptly and be life threatening. Even with early adequate drainage and antibiotic therapy, the patient's condition deteriorated and she ultimately died. To the best of our knowledge, this is the first case of K. pneumoniae invasive liver abscess syndrome with sep...



Incidence, epidemiology and clinical features of Kawasaki disease in Catalonia, Spain.

Sun, 06 Mar 2016 00:18:01 +0100

CONCLUSIONS: This is the first population-based study on the epidemiology of KD in the western Mediterranean area. Incidence, clinical features and treatment plans in our cohort are similar to those described in other European studies. PMID: 26939753 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)



DH rejects call to widen access to men B vaccine

Fri, 04 Mar 2016 13:53:00 +0100

The Department of Health has said widening access to the new meningitis B vaccine, as called for in a petition signed by over 800,000 people, would not be cost-effective. (Source: Nursing Times)



Mother who lost her legs to meningitis is terrified her children might get disease

Fri, 04 Mar 2016 10:07:14 +0100

Clare Brown, 32, Selsey, West Sussex, fears daughters Alexcia and Savanna, 5 and 6, are not protected against meningitis, which left her with brain damage, vertigo and double vision. (Source: the Mail online | Health)