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MedWorm: Hepatitis



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Hepatitis category.



Last Build Date: Tue, 29 Mar 2016 16:32:34 +0100

 



Challenges and opportunities in the management of chronic hepatitis B infection

Tue, 29 Mar 2016 09:23:41 +0100

Abstract: HBsAg seroclearance before the age of 50 years of age is associated with decreased incidence of hepatocellular carcinoma. Studies of spontaneous HBsAg seroclearance select special population with low viral activities. However HBsAg seroclearance is only achievable in 8-11% of patients with the current treatment agents (interferon and nucleoside analogues [NAs]). The pattern of HBsAg level decline during NA treatment is variable. (Source: International Journal of Infectious Diseases)

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The long-term impact of antiretroviral therapy in resource-limited settings

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: With the advent of antiretroviral therapy (ART), HIV has shifted to a chronic manageable condition, even in resource-limited settings. Now, the long-term effects of being on ART and living with HIV are emerging. These include the adverse effects of long-term ART and morbidity due to non AIDS complications such as cardiovascular, hepatic, renal, metabolic and neurocognitive disease, cancers and ageing as well as complications due to hepatitis B and C co-infection. Although first and second-line antiretrovirals are available in resource-limited settings, new antiretrovirals are urgently needed in order to sustain HIV as a chronic manageable condition. (Source: International Journal of Infectious Diseases)



Safety, immune lot-to-lot consistency and non-inferiority of a fully liquid pentavalent DTwP-HepB-Hib vaccine: Results from Phase III licensure study of Shan5™

Tue, 29 Mar 2016 09:23:40 +0100

Background: Pentavalent combination vaccines perform a key role in increasing vaccine coverage rate; and provide an efficient and reliable method of implementing WHO recommendations for controlling diphtheria, tetanus, pertussis, hepatitis B and Hib infections on a worldwide basis. (Source: International Journal of Infectious Diseases)



Hepatitis E vaccine - where are we today?

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: Outbreaks and sporadic cases of hepatitis E occur globally with large epidemics occurring in resource-limited regions where there is over-crowding, unsanitary conditions and poor health services including refugee camps and internally displaced populations. The World Health Organization (WHO) estimates that the virus infects 20 million people each year of which 3 million are acute hepatitis cases and 56,600 die. Fulminant hepatic failure is reported in those infected in the third trimester of pregnancy in some regions. (Source: International Journal of Infectious Diseases)



HCV state of the art: Who, when and how to treat

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: Significant progress has been made in treatment of hepatitis C (HCV) infection since the virus was discovered over 26 years ago. After introduction of directly acting agents (DAAs), the treatment for hepatitis C has significantly improved both in efficacy and tolerability. Clinical trials using combinations of DAAs have shown excellent sustained viral response rates (SVRs) in patients with all HCV genotypes. Hepatitis C has now become a curable disease from a chronic disease, and complications such as liver cirrhosis and hepatocellular carcinoma (HCC) are preventable. (Source: International Journal of Infectious Diseases)



Hepatitis C infection in people who inject drugs

Tue, 29 Mar 2016 09:23:40 +0100

Abstract: Hepatitis C virus (HCV) is a major global public health problem. Worldwide, ∼184 million people are infected, with a higher prevalence in developing countries compared to developed countries in North America and Europe. However, vulnerable populations (e.g., people who inject drugs (PWID), Aboriginal people, and incarcerated individuals) account for >80% of new infections and most of the onward transmission. In Bangladesh, PWID account for the vast majority of HCV infections. (Source: International Journal of Infectious Diseases)

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Outbreak investigation of acute viral hepatitis in Kangra valley, Himachal Pradesh, India, 2014-2015

Tue, 29 Mar 2016 09:23:38 +0100

Background: India is endemic for viral hepatitis A (HAV) infection with 66% of states reporting at least one outbreak from 2011 to 2013. Following media reports in January 2015, we investigated a jaundice outbreak in Kangra town of Himachal Pradesh Valley with the following objectives: (1) assess the magnitude, (2) identify the source, and (3) initiate preventive measures. (Source: International Journal of Infectious Diseases)



Prevalence of hepatitis delta virus in Sindh and Punjab (Pakistan) epidemiological survey.

Tue, 29 Mar 2016 09:23:38 +0100

Background: Hepatitis D virus or delta virus (HDV) is a small, defective RNA virus that can infect only individuals who have hepatitis B virus which acts as the carrier host. The prevalence of HDV antibodies in Pakistani hepatitis B surface antigen (HBsAg) positive individuals is approximately 16.6%. So there is a pool of at least 800,000 anti-HDV positive HBsAg positive individuals in the country. Although the prevalence of hepatitis virus infections in Pakistan is still unknown, limited data indicate that the exposure rate to HBV is 35-38% with 4% being carriers and 32% having anti-HBV surface antibodies through natural conversion. (Source: International Journal of Infectious Diseases)



Hepatitis A outbreak due to contaminated public water in Tiruchirappalli Corporation, Tamil Nadu, India, 2015

Tue, 29 Mar 2016 09:23:38 +0100

Background: Hepatitis A (HAV) outbreaks are due to faecal contaminated water or inadequately treated water. On 9 October 2015, Kemps stone area (population=665) of Tiruchirappalli, reported 42 cases of jaundice, all aged less than 20 years. We investigated to identify risk factors and propose recommendations. (Source: International Journal of Infectious Diseases)



Hepatitis B and Human immunodeficiency virus co-infection among pregnant women in resource limited high endemic setting, Addis Ababa, Ethiopia: Implications for current and emerging prevention and control measures

Tue, 29 Mar 2016 09:23:38 +0100

Background: Pregnant women infected with hepatitis B virus (HBV) and HIV can transmit the infection to their fetuses and newborns. The study was intended to determine co-infection of hepatitis B and Human immunodeficiency virus and assessing risk factors among ANC visiting women. (Source: International Journal of Infectious Diseases)



Mother T follicular helper cells prevent vertical transmission of Hepatitis B to their babies

Tue, 29 Mar 2016 09:23:38 +0100

Background: Chronic Hepatitis B infection (CHBV) is a leading cause of advanced liver diseases. Mother to child transmission accounts for most cases of CHBV infections. The risk is highest in HBsAg+ve and HBeAg+ve mothers (transmission rate: 70%–90%). Follicular T helper cells (TFH) have shown a preventive role against HBV through activating the B cell mediated humoral immunity in patients. Role of TFh cells in HBV Transmission is elusive. Hypothesis: TFH cells are essential for preventing HBV transmission and impairment of these cells may leads to vertical HBV transmission. (Source: International Journal of Infectious Diseases)

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Analysis of surveillance data for Hepatitis C in China: From 2005 to 2014

Tue, 29 Mar 2016 09:23:37 +0100

Background: Hepatitis C virus infection represents a significant global public health problem. The disease has been listed as one of the secondary notifiable diseases in China. Early prediction of Hepatitis C is of great importance for heath planning and management. Time series analysis is an effective way to understand the behavior of the epidemic infection. (Source: International Journal of Infectious Diseases)



Hospital based sentinel surveillance of bacterial meningitis in India

Tue, 29 Mar 2016 09:23:37 +0100

Background: Pentavalent vaccine (a combination vaccine which protects against five killer diseases- diphtheria, pertussis, tetanus, hepatitis B and Haemophilus influenzae type B) is being introduced in various states of India as a part of Universal Immunization Programme. In this context it is critical to establish sentinel sites across India for surveillance of H.influenzae type B meningitis and use this opportunity also for surveillance of pneumococcal and meningococcal meningitis. Keeping this in mind a hospital-based sentinel surveillance network was established at 11 places across the country and this study reports the results of first three years of this surveillance program (Source: International Journal of Infectious Diseases)



Hepatitis E outbreak among factory workers due to contaminated factory water, Mandya District, Karnataka, India, 2015

Tue, 29 Mar 2016 09:23:37 +0100

Background: Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis with over 2 billion cases per year. In India, HEV accounts for 60% of acute viral hepatitis cases. On 10 July 2015, Mandya district in Karnataka, India reported 50 cases of jaundice from factory A. We investigated to describe the outbreak, identify risk factors and propose recommendations. (Source: International Journal of Infectious Diseases)



Predictors, outcome, profile of anti-tubercular drug induced hepatitis – A prospective nested case - control study in a South Indian tertiary hospital

Tue, 29 Mar 2016 09:23:36 +0100

Background: Tuberculosis (TB) remains a major global health problem . The first line anti-tubercular drugs are hepatotoxic. Despite adequate knowledge, we are still unable to predict anti-tubercular drug induced liver injury (DILI) before initiation of treatment. (Source: International Journal of Infectious Diseases)



Survey of Hepatitis B surface Antigen (HBsAg) prevalence and its risk factors among pregnant women at Bishoftu Hospital, Oromia Regional State, Ethiopia

Tue, 29 Mar 2016 09:23:35 +0100

The objective of the study was to investigate sero-prevalence of hepatitis B surface antigen and assess risk factors among pregnant women. (Source: International Journal of Infectious Diseases)

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Characterisation of chronic hepatitis B virus carriers with viral load and correlation with other viral markers

Tue, 29 Mar 2016 09:23:35 +0100

This study was carried out with objectives; profiling of viral markers in HBV carriers with viral load, correlation of ALT levels, HBe Ag status with their viral load, to determine the mutation and response to antiviral therapy in treated and treatment naïve individuals. (Source: International Journal of Infectious Diseases)



Prevalence of hepatis C virus infection among asymptomatic Pakistani children

Tue, 29 Mar 2016 09:23:35 +0100

This study was conducted to determine the prevalence of hepatitis C virus (HCV) infection in patients admitted in children ward and attending children outdoor, at Akhtar Saeed hospital, Lahore (a teaching trust hospital). (Source: International Journal of Infectious Diseases)



Upsurge in vaccine preventable hepatitis A virus infection in adult patients from a tertiary care hospital of North India

Tue, 29 Mar 2016 09:23:35 +0100

Background: Prevalence of acute viral hepatitis A among adult in developing country is low due to pre exposure of Hepatitis A virus (HAV) during childhood and adolescence. An increase in acute viral hepatitis A infection among admitted adult patients is being observed in this centre. Hence,study done to know the prevalence of Hepatitis A virus (HAV) and Hepatitis E virus (HEV) in adult patients of acute hepatitis admitted in Gastroenterology Department, Nehru Hospital, PGIMER, Chandigarh. (Source: International Journal of Infectious Diseases)



Genetic variability and molecular evolution of hepatitis B virus in HIV co-infected patients on lamivudine based anti-retroviral therapy: A 5 year longitudinal study

Tue, 29 Mar 2016 09:23:35 +0100

Background: Reports on the concomitant impact of HIV infection and long term cross-reactive HAART on the genetic variability and molecular evolution of HBV over time are limited. This longitudinal study retrospectively investigated the molecular characteristics of chronic HBV in HIV co-infected patients on lamivudine (3TC)-based HAART, over the course of a 5 year period. (Source: International Journal of Infectious Diseases)



Serum levels of soluble CD26, a novel prognostic marker for acute hepatitis E infection

Tue, 29 Mar 2016 09:23:35 +0100

Background: Even without treatment, most of acute hepatitis E virus (HEV) infected patients resolve HEV but sometimes the disease leads to acute liver failure, chronic infection, or extrahepatic symptoms. The mechanisms of HEV pathogenesis appear to be substantially immune mediated. However, the immune responses to HEV are not precisely identified. The aim of this study was evaluation of Th1/Th2 ratio by determining serum soluble markers from Th1 and Th2 cells in acute HEV infected patients. (Source: International Journal of Infectious Diseases)

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Indian experience with use of sofusbuvir for treatment of hepatitis C virus infection: Preliminary data from southern India

Tue, 29 Mar 2016 09:23:35 +0100

This study aims to look at the response to sofosbuvir (SOF) (an NS5B nucleotide analog) in combination with RBV with/ without Peg IFN among Indian patients. (Source: International Journal of Infectious Diseases)



Thrombocytopenia and anti-platelet antibodies in patients with chronic hepatitis C

Tue, 29 Mar 2016 09:23:35 +0100

Background: One of the key position in hemostasis belongs to surface platelet receptors (SPR) - glycoproteins (GP) Ia/IIa, Ib/IX and IIb/IIIa. Antibodies to SPR can lead to development of thrombocytopenia in patients with chronic HCV-infection. However the role of different types of antibodies in this process is unknown. (Source: International Journal of Infectious Diseases)



Hepatitis B virus genotypes and unique recombinants circulating among outpatients in selected hospitals in Kenya

Tue, 29 Mar 2016 09:23:35 +0100

Background: HBV causes 780,000 deaths yearly worldwide. It's endemic in Africa and of the ten known genotypes (A-J), A,D and E are prominent in Africa. Kenya is geographically located at the junction of these three genotypes and there is a paucity of HBV genotyping data. (Source: International Journal of Infectious Diseases)



Molecular diversity of Hepatitis B virus (HBV) x gene: A preliminary report from Kerala

Tue, 29 Mar 2016 09:23:35 +0100

This study attempts to investigate genetic variability of the HBV x gene in patients with chronic hepatitis B (CHBV) infection at a tertiary care hospital in Kerala, South India. (Source: International Journal of Infectious Diseases)



Prevalence of assymptomatic hepatitis B virus among sexually active youths in a rural community of Ebonyi state, Southeast Nigeria

Tue, 29 Mar 2016 09:23:35 +0100

Background: Three major routes spread of hepatitis B virus in developing country such as Nigeria are prenatal, horizontal and sexual transmission. The main routes of transmission are neonatal with HBV carrier mother infecting her infant usually during birth or soon after birth following close contact, transfer of HBV via cuts, sexual transmission, transfusion of infected blood or blood products, needle stick injury, re-use of HBV contaminated needles, syringes, lancets and instruments including those used in tribal ceremonies , (Source: International Journal of Infectious Diseases)

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Hepatitis A virus outbreak in a compound in Tshwane district, Gauteng, South Africa: October 2014-March 2015

Tue, 29 Mar 2016 09:23:35 +0100

Background: Hepatitis A is a contagious viral infection caused by hepatitis A virus (HAV). It is strongly associated with socio-economic indicators such as access to clean water and sanitation. On 16 February 2015, the Tshwane Outbreak Response Unit (ORU) was notified by a laboratory of an increase in blood samples that tested positive for HAV IgM. On the same day Tshwane ORU team was assembled to conduct further investigations. (Source: International Journal of Infectious Diseases)



Multiple siRNAs against HCV and host genes are more effective in inhibition of HCV replication

Tue, 29 Mar 2016 09:23:35 +0100

Background: Hepatitis C virus is a major cause of chronic liver diseases such as chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The present available anti-HCV drugs, Pegylated interferon-α (IFN- α) and Ribavirin have limited efficacy, resistance problems and high manufacturing cost. Among the newer approaches to curb the viral replication, RNA interference (RNAi) based approaches have shown tremendous prospective to inhibit HCV replication. (Source: International Journal of Infectious Diseases)



Hepatitis A outbreak associated with unsafe drinking water in a medical college student's hostel, New Delhi, India, 2014

Tue, 29 Mar 2016 09:23:35 +0100

Background: An outbreak of jaundice was reported from a girl's hostel (Old Girl's Hostel; OGH) of Maulana Azad Medical College (MAMC), Delhi in January-2014. We conducted an investigation to identify the etiological agent, source of infection, potential risk factors and to recommend control measures. (Source: International Journal of Infectious Diseases)



High prevalence of hepatitis C and hepatitis B infection among pregnant women and their blood donors attending a surgical referral clinic in District Naushahro Feroze, Sindh, Pakistan 2014

Tue, 29 Mar 2016 09:23:35 +0100

Background: Reports on burden of hepatitis C and hepatitis B virus (HCV/HBV) are a big challenge for district to minimize the transmission of associated risk factors. Study was conducted to know the prevalence of HCV/HBV infection in pregnant women and their blood donors attended a surgical referral clinic for cesarean delivery. Study was therefore undertaken to determine the prevalence of HCV/HBV infection among pregnant women and their blood donors. (Source: International Journal of Infectious Diseases)



The efficacy and particular side effects of therapy peginterferon alpha-2a acute hepatitis C hemodialysed patients

Tue, 29 Mar 2016 09:23:35 +0100

Background: Peginterferon alpha-2a is a known standard therapy for patients with acute HCV infection. Our experience with peginterferon in hemodialised patients with hepatitis C started with a million question and uncertainties. This because of the: (Source: International Journal of Infectious Diseases)

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Identification of occult hepatitis B virus (HBV) infection and viral antigens in healthcare workers who presented low to moderate levels of anti-HBs after HBV vaccination

Tue, 29 Mar 2016 09:23:35 +0100

Background: Worldwide, healthcare workers (HCW)s show different levels of response to hepatitis B virus (HBV) vaccine. One of the factors associated with vaccine unresponsiveness may be the existence of current or past HBV infection. Regardless of the presence of HBsAg (overt infection), occult HBV infection (OBI, defined as presence of HBV DNA in the absence of HBsAg), might be also accounted in some non-or hypo-response cases. (Source: International Journal of Infectious Diseases)



Is HLA-DRB1*13 allele a risk factor for prognosis of hepatitis C virus infection?

Tue, 29 Mar 2016 09:23:35 +0100

In this study, we aimed to investigate the effects of HLA-DRB1 alleles on the treatment response and prognosis of the HCV infection. (Source: International Journal of Infectious Diseases)



Outbreak investigation of suspected hepatities E among South Sudan refugees, Gambella regional state, Ethiopia, July 2014

Tue, 29 Mar 2016 09:23:35 +0100

Background: Hepatitis E is a liver disease caused by the hepatitis E virus: it is a common cause of acute hepatitis with poor sanitation and hygiene. First week of June, 2014 Gambella regional state health bureau reported cluster of acute jaundice syndrome among South Sudan refugees living in Gambella regional state of Ethiopia. An investigation was conducted to identify the etiology of the outbreak, and to recommend control and prevention methods. (Source: International Journal of Infectious Diseases)



Correlation of Interferon-gamma and Interleukin-28B levels in patients with chronic hepatitis C viral infection with or without Schistosoma mansoni coinfection

Tue, 29 Mar 2016 09:23:35 +0100

Background: Hepatitis C viral infection (HCV) presents a serious health problem worldwide and is endemic in Egypt. Egypt has the highest prevalence of HCV in the world with an infection rate of one in five individuals. HCV infection in Egypt is usually associated with Schistosoma mansoni coinfection, another endemic disease in Egypt since the Pharos. Interleukin-28B (IL-28B) and interferon-gamma (IFN-g) are two of the mostly recognized immunological cytokines appearing in response to these diseases. (Source: International Journal of Infectious Diseases)



New treatments for hepatitis C virus (HCV): scope for preventing liver disease and HCV transmission in England

Tue, 29 Mar 2016 09:23:11 +0100

Summary New direct‐acting antivirals have the potential to transform the hepatitis C (HCV) treatment landscape, with rates of sustained viral response in excess of 90%. As these new agents are expensive, an important question is whether to focus on minimizing the consequences of severe liver disease, or reducing transmission via ‘treatment as prevention’. A back‐calculation model was used to estimate the impact of treatment of mild, moderate and compensated cirrhosis on incident cases of HCV‐related end‐stage liver disease/hepatocellular carcinoma (ESLD/HCC). In addition, a dynamic model was used to determine the impact on incidence and prevalence of chronic infection in people who inject drugs (PWID), the main risk group in England. Treating 3500 cirrhotics per year was predic...

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Safety of HIV PrEP in Individuals With Active Hepatitis BSafety of HIV PrEP in Individuals With Active Hepatitis B

Tue, 29 Mar 2016 08:26:22 +0100

Is HIV pre-exposure prophylaxis safe for individuals with HBV infection? JAIDS: Journal of Acquired Immune Deficiency Syndromes (Source: Medscape Hiv-Aids Headlines)






Lb-s&t-36 recovery from neurologic impairment in murine model of coronavirus-induced demyelination does not directly correlate with improvement of neurogenic bladder dysfunction: long-term follow up study

Mon, 28 Mar 2016 19:24:00 +0100

Patients with multiple sclerosis (MS) often develop neurogenic lower urinary tract symptoms (LUTS) which occur in 50-90 percentage of these patients. To understand how neurodegenerative changes in the central nervous system (CNS) affect the function of the lower urinary tract, our group previously investigated the correlation between the degree of neurological impairment and development of neurogenic bladder dysfunction in a murine model of MS. Coronavirus-induced encephalomyelitis (CIE) was induced by intracranial injection of mouse hepatitis virus (MHV). (Source: The Journal of Urology)



Axium Healthcare Pharmacy Launches #oneteam Program – Processes PAs...

Mon, 28 Mar 2016 17:07:02 +0100

#oneteam program ensures providers that all hepatitis C referrals can be sent to Axium(PRWeb March 28, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13292769.htm (Source: PRWeb: Medical Pharmaceuticals)



Factors Influencing Metabolic Parameters in Chronic HCVFactors Influencing Metabolic Parameters in Chronic HCV

Mon, 28 Mar 2016 15:39:15 +0100

What does this new article tell us about the relationship between menopausal status and metabolic abnormalities and the connection to hepatitis C management? Journal of Viral Hepatitis (Source: Medscape Today Headlines)

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Treat chronic hepatitis C virus infection in decompensated cirrhosis – pre‐ or post‐liver transplantation? the ironic conundrum in the era of effective and well‐tolerated therapy

Mon, 28 Mar 2016 14:34:09 +0100

Summary The management of hepatitis C virus (HCV) infection in patients with decompensated cirrhosis has evolved dramatically over the past few years mainly due to the availability of all‐oral antiviral regimens. The currently approved all‐oral direct‐acting antivirals (DAA) containing sofosbuvir, ledipasvir, daclatasvir and ribavirin, in various combinations, have shown to be safe and effective in patients with decompensated cirrhosis with sustained virological response (SVR) rates nearly comparable to those with well‐compensated liver disease. Unique issues yet remain such as the challenges with renal insufficiency, tolerability of ribavirin and risk of further hepatic decompensation with a protease inhibitor‐based regimen. While most patients who achieve SVR have demonstrated ...



A Focus on Hepatitis C: OutcomesA Focus on Hepatitis C: Outcomes

Mon, 28 Mar 2016 13:56:31 +0100

Dr William Balistreri completes his three-part series on hepatitis C with a discussion about possible outcomes and a glimpse into the future of treatment. Medscape Gastroenterology (Source: Medscape Today Headlines)



Coinfection of Schistosoma Species with Hepatitis B or Hepatitis C Viruses.

Mon, 28 Mar 2016 10:25:02 +0100

Authors: Abruzzi A, Fried B, Alikhan SB Abstract Although a considerable number of studies have been undertaken to date, it is still controversial as to whether or not coinfection with schistosomiasis increases the susceptibility to or progression from Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infection. This review is a closer examination of the key studies conducted on human populations on clinical factors that were published in English between 1975 and January 2015. Our review is mainly based on tables containing the salient information, which are arranged first by study population, country of study and publication date. We provide further explanation, clarification and discussion in the text. As such, it includes both studies that have been conducted on general populat...



Sequential therapy with entecavir and pegylated interferon in a cohort of young patients affected by chronic hepatitis B

Mon, 28 Mar 2016 07:07:05 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)



Multiplex electrochemiluminescence DNA sensor for determination of hepatitis B virus and hepatitis C virus based on multicolor quantum dots and Au nanoparticles.

Mon, 28 Mar 2016 04:27:02 +0100

Authors: Liu L, Wang X, Ma Q, Lin Z, Chen S, Li Y, Lu L, Qu H, Su X Abstract In this work, a novel multiplex electrochemiluminescence (ECL) DNA sensor has been developed for determination of hepatitis B virus (HBV) and hepatitis C virus (HCV) based on multicolor CdTe quantum dots (CdTe QDs) and Au nanoparticles (Au NPs). The electrochemically synthesized graphene nanosheets (GNs) were selected as conducting bridge to anchor CdTe QDs551-capture DNAHBV and CdTe QDs607-capture DNAHCV on the glassy carbon electrode (GCE). Then, different concentrations of target DNAHBV and target DNAHCV were introduced to hybrid with complementary CdTe QDs-capture DNA. Au NPs-probe DNAHBV and Au NPs-probe DNAHCV were modified to the above composite film via hybrid with the unreacted complementary CdTe ...

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CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus‐positive patients with resected hepatocellular carcinoma

Sun, 27 Mar 2016 22:00:00 +0100

This study investigated whether the expression of CD44 variant 9 (CD44v9) might be a functional marker of tumor‐initiating stem‐like cells in primary hepatocellular carcinomas (HCCs) of hepatitis C virus (HCV)+ patients and provide an indicator of patient survival, as well as associated mechanisms. A total of 90 HCV+ HCC patients who underwent surgery from 2006 to 2011 were enrolled and monitored for 2–8 years. Expression of CD44v9 was validated immunohistochemically in all HCCs, followed by comparative proteome, survival, and clinicopathological analyses. CD44 variant 8–‐10 was further evaluated in diethylnitrosamine‐induced HCCs of C57Bl/6J mice. Focally localized CD44v+ cells with a membranous staining pattern were detected in human HCV+ and mouse HCCs. CD44v9+ cells of HCCs...



HCV and Lymphoma

Sun, 27 Mar 2016 22:00:00 +0100

(Source: Hepatology)






Reply: Acute and Chronic Hepatitis E Virus Infection in HIV‐Infected U.S. Women

Sun, 27 Mar 2016 22:00:00 +0100

(Source: Hepatology)



Caspofungin salvage therapy in pneumocystis jirovecii pneumonia

Sun, 27 Mar 2016 22:00:00 +0100

Publication date: Available online 28 March 2016 Source:Journal of Microbiology, Immunology and Infection Author(s): Wen-Sen Lee, Po-Ren Hsueh, Tai-Chin Hsieh, Fu-Lun Chen, Tsong-Yih Ou, Shio-Shin Jean pneumocystis jirovecii pneumonia (PJP) is a severe complication and leading cause of deaths among human immunodeficiency virus (HIV)-infected patients. Although trimethoprim/sulfamethoxazole (TMP/SMZ) is well known for its effectiveness as empiric and target therapy, but TMP/SMZ is associated with various side effects (including skin rash, leucopenia, hepatitis and diarrhea). The clinical evidence of synergistic activity of caspofungin to TMP/SMZ or salvage treatment of PJP is controversy till now. Here, we report a HIV-infected patient complicated with PJP, he suffered from skin ras...

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Pathogenesis of Alcoholic Liver Disease

Sun, 27 Mar 2016 22:00:00 +0100

Alcoholic liver disease includes a broad clinical-histological spectrum from simple steatosis, cirrhosis, acute alcoholic hepatitis with or without cirrhosis to hepatocellular carcinoma as a complication of cirrhosis. The pathogenesis of alcoholic liver disease can be conceptually divided into (1) ethanol-mediated liver injury, (2) inflammatory immune response to injury, (3) intestinal permeability and microbiome changes. Corticosteroids may improve outcomes, but this is controversial and probably only impacts short-term survival. New pathophysiology-based therapies are under study, including antibiotics, caspase inhibition, interleukin-22, anakinra, FXR agonist and others. These studies provide hope for better future outcomes for this difficult disease. (Source: Clinics in Liver Disease)



HBcrAg is a predictor of hepatocellular carcinoma development: an analysis using time-dependent receiver operating characteristics

Sun, 27 Mar 2016 22:00:00 +0100

Chronic hepatitis B (CHB) affects over 350 million people worldwide. Long-term complications of infection include cirrhosis and hepatocellular carcinoma (HCC), which together cause over 500,000 deaths annually [1,2]. Hepatitis B surface antigen (HBsAg)-positive patients have a 70-fold increased risk of developing HCC compared to their HBsAg-negative counterparts [3,4]. Hepatitis B virus (HBV) infection is endemic in Southeast Asia, China, Taiwan, Korea, and sub-Saharan Africa, where up to 85–95% of patients with HCC are HBsAg positive [5]. (Source: Journal of Hepatology)



Risk factors associated with incident sexually transmitted infections in HIV‐positive patients in the Australian HIV Observational Database: a prospective cohort study

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsIn this cohort of individualsbeing treated with antiretroviral drugs, those who were MSM, who were 30–39 years old, and who had a prior history of STI, were at highest risk of a further STI diagnosis. (Source: HIV Medicine)



Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

Sun, 27 Mar 2016 22:00:00 +0100

Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide with an increased prevalence of metabolic, macro-, and microvascular complications. The primary causes of mortality in NAFLD are cardiovascular disease (CVD), malignancy, and liver disease. NAFLD is a multisystem disease that affects a variety of extrahepatic organ systems. The main focus of this review is to summarize the reported extrahepatic associations, which include CVD, chronic kidney disease, obstructive sleep apnea, osteoporosis, psoriasis, colorectal cancer, iron overload, and various endocrinopathies (e.g., type 2 diabetes mellitus, thyroid dysfunction, and polycystic ovarian syndrome). Due to the systemic manifestations of NAFLD, patients require a multidiscipl...



Chronic hepatitis B infection and risk of antituberculosis drug-induced liver injury: Systematic review and meta-analysis

Sun, 27 Mar 2016 22:00:00 +0100

Conclusion This meta-analysis suggests that CHBI may increase the risk of ATDILI in the standard combination therapy for active TB. Close follow-up and regular liver test monitoring are mandatory to treat TB in chronic hepatitis B carriers. (Source: Journal of the Chinese Medical Association)

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15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy

Sat, 26 Mar 2016 23:00:00 +0100

Conclusion 15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating the anti-oxidative stress factor HO-1 and reducing the production of cytokines and ROS, thereby inhibiting hepatic cell autophagy probably induced by ROS. (Source: Biomedicine and Pharmacotherapy)



Simeprevir or telaprevir with peginterferon and ribavirin for recurrent hepatitis C after living‐donor liver transplantation: A Japanese multicenter experience

Sat, 26 Mar 2016 23:00:00 +0100

ConclusionSimeprevir‐based triple therapy for recurrent hepatitis C after living‐donor liver transplantation resulted in a high SVR rate and good tolerability, especially in treatment‐naïve patients. (Source: Hepatology Research)



Characterization of partial NS5B region among hepatitis C virus genotype 6 subtypes isolated from thai blood donors

Sat, 26 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)



Fas ligand based immunotherapy: A potent and effective neoadjuvant with checkpoint inhibitor properties, or a systemically toxic promoter of tumor growth?

Sat, 26 Mar 2016 21:34:04 +0100

Authors: Modiano JF, Bellgrau D Abstract Fas ligand (FasL, CD95L) is a 40-kDa type II transmembrane protein that binds to Fas (CD95) receptors and promotes programmed cell death. Fas receptors are expressed at higher levels in many tumors than in normal cells; however, systemic administration of FasL or agonistic anti-Fas antibodies to mice with tumors caused lethal hepatitis. Somewhat paradoxically, elimination of Fas or FasL from tumors also leads to death induced by CD95 receptor/ligand elimination (DICE). At face value, this suggests that Fas signaling not only kills normal cells, but that it also is essential for tumor cell survival. Targeting this pathway may not only fail to kill tumors, but instead may even enhance their growth, leading some to report the demise of Fas liga...



Preventing Transmission of Zika Virus in Labor and Delivery Settings Through Implementation of Standard Precautions - United States, 2016.

Sat, 26 Mar 2016 14:09:02 +0100

Authors: Olson CK, Iwamoto M, Perkins KM, Polen KN, Hageman J, Meaney-Delman D, Igbinosa II, Khan S, Honein MA, Bell M, Rasmussen SA, Jamieson DJ Abstract Zika virus transmission was detected in the Region of the Americas (Americas) in Brazil in May 2015, and as of March 21, 2016, local mosquito-borne transmission of Zika virus had been reported in 32 countries and territories in the Americas, including Puerto Rico and the U.S. Virgin Islands.* Most persons infected with Zika virus have a mild illness or are asymptomatic. However, increasing evidence supports a link between Zika virus infection during pregnancy and adverse pregnancy and birth outcomes (1), and a possible association between recent Zika virus infection and Guillain-Barré syndrome has been reported (2). Although Zik...

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Cost-effectiveness of Lamivudine, Telbivudine, Adefovir Dipivoxil and Entecavir on decompensated hepatitis B virus-related cirrhosis.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: LMV, ADV, LdT, LMV+ADV and ETV were all effective on treatment of decompensated hepatitis B virus-related cirrhosis whereas ETV and LMV+ADV were recommended. PMID: 27010143 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Factors associated with HIV and HBV co-infection in Northern Thailand

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Our findings suggest that having a good education and having a good immune status are a protective factor of HIV/HBV co-infection. A practical approach would be a provision of wide access to general and sex education on the risk and prevention of HIV, HBV, and a promotion of HBV immunization. (Source: Asian Pacific Journal of Tropical Disease)



Reply

Fri, 25 Mar 2016 23:00:00 +0100

We thank Dr Fan and Dr Sonneveld for their comments and interest in our work. In our study, we have demonstrated a higher cumulative hepatitis B surface antigen (HBsAg) seroclearance at week 72 among chronic hepatitis B virus (HBV)-infected patients who received 48-week tenofovir disoproxil fumarate (TDF) and pegylated interferon alfa-2a (Peg-IFN) combination treatment as compared to either treatment as monotherapy.1 We agree that the overall cumulative HBsAg seroclearance rate was not very high, only 9.1%, for the combination treatment. (Source: Gastroenterology)



Combination Therapy With Tenofovir and Peginterferon May Not Be Translated Into Current Clinical Practice

Fri, 25 Mar 2016 23:00:00 +0100

We read with great interest the paper by Marcellin et al published in Gastroenterology.1 The authors demonstrated that combination therapy with tenofovir disoproxil fumarate (TDF) and pegylated interferon alfa-2a (Peg-IFN) for 48 weeks could result in higher rate of hepatitis B surface antigen (HBsAg) loss than either monotherapy in the multicenter international trial. However, the key question is whether the new strategy is good enough to be translated into current clinical practice. (Source: Gastroenterology)



Hepatitis E virus seroprevalence among schistosomiasis patients in Northeastern Brazil

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion This study demonstrates that the seroprevalence of HEV is high in patients with SM in Northeastern of Brazil. Past HEV infection is associated with higher frequency of liver enzymes abnormalities. HEV infection and its role on the severity of liver disease should be further investigated among patients with SM. (Source: The Brazilian Journal of Infectious Diseases)

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Simeprevir-Sofosbuvir for Chronic Hepatitis C With CirrhosisSimeprevir-Sofosbuvir for Chronic Hepatitis C With Cirrhosis

Fri, 25 Mar 2016 18:30:27 +0100

The combination of simeprevir (SMV) and sofosbuvir (SOF) is effective treatment for patients with chronic hepatitis C virus (HCV) genotype 1 infection and cirrhosis, according to results from OPTIMIST-2. Reuters Health Information (Source: Medscape Gastroenterology Headlines)



C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Ng KY, Chai S, Tong M, Guan XY, Lin CH, Ching YP, Xie D, Cheng AS, Ma S Abstract Tumor relapse after chemotherapy typifies hepatocellular carcinoma (HCC) and is believed to be attributable to residual cancer stem cells (CSCs) that survive initial treatment. Chronic infection with hepatitis B virus (HBV) has long been linked to the development of HCC. Upon infection, random HBV genome integration can lead to truncation of hepatitis B virus X (HBx) protein at the C-terminus. The resulting C-terminal-truncated HBx (HBx-ΔC) was previously shown to confer enhanced invasiveness and diminished apoptotic response in HCC cells. Here, we found HBx-ΔC to promote the appearance of a CD133 liver CSC subset and confer cancer and stem cell-like features in HCC. HBx-ΔC was exclusively ...



Hepatitis apparently spread via stress test at W. Va. clinic

Fri, 25 Mar 2016 16:17:08 +0100

People in West Virginia who went in for a cardiac stress test got a letter recently that may cause them stress. (Source: WDSU.com - Health)



Antibiotics Side Effects on the Mitochondria

Fri, 25 Mar 2016 15:38:08 +0100

Science is just beginning to understand how important your mitochondria are to warding off the diseases of aging. And, as usual, mainstream medicine is lagging way behind. Along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are another key component of the anti-aging equation. You see, these tiny organelles in your cells are the power plants that turn fuel into energy for your body. Healthy mitochondria keep you young and energetic.  Research shows that damaged mitochondria can lead to: Schizophrenia and bipolar disorder; Alzheimer’s and Parkinson’s disease; Epilepsy, migraines, and nerve pain; Loss of muscle control and balance; Strokes, heart disease, and coronary artery disease; Chronic fatigue syndrome and fibromyalgia;...



Gilead to Pay Merck $200 Million in Damages in Hepatitis C Drug Suit

Fri, 25 Mar 2016 13:43:05 +0100

A federal jury found that Gilead Sciences infringed on two patents held by Merck and its partner Ionis Pharmaceuticals to treat the viral disease. (Source: WSJ.com: Health)

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Understanding Zika Virus: An Informational Briefing at the Gladstone Institutes

Fri, 25 Mar 2016 11:15:24 +0100

Gladstone Institutes. 02/11/2016This 48-minute webinar features speakers who explain what is known about Zika virus and how it might be combatted as infections rise across the globe. The speakers are applying their knowledge of hepatitis C and dengue virus, which are related to Zika virus, to study how Zika virus infects cells and leads to disease. They discuss how they hope to identify potential therapeutic targets for Zika. (Video or Multimedia) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)



Resolution of Hepatic Artery Thrombosis in 2 Pediatric Liver Transplant Patients

Fri, 25 Mar 2016 11:13:48 +0100

ABSTRACT: Hepatic artery thrombosis (HAT) is a serious complication after liver transplantation. This is the first report of spontaneous resolution of HAT in pediatric liver transplant patients on low molecular weight heparin therapy. A total of 2 patients, a 26-month-old boy who presented with acute liver failure and required emergent liver transplantation and a 15-year-old boy with ulcerative colitis and autoimmune hepatitis-primary sclerosing cholangitis overlap underwent liver transplantation for progressive cirrhosis; both developed HAT during the postoperative period. They were both treated with low molecular weight heparin. Follow-up imaging for both patients showed resolution of HAT without evidence of collateral flow. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Hepatitis C Kills More People Than HIV Infection

Fri, 25 Mar 2016 07:00:00 +0100

! (Source: eMedicineHealth.com)



Autoimmune hepatitis: a manifestation of immune reconstitution inflammatory syndrome in HIV infected patients?

Fri, 25 Mar 2016 06:03:02 +0100

Conclusions Immune reconstitution related autoimmune hepatitis should be considered in the differential diagnosis of hepatitis in the HIV-infected patient on antiretroviral therapy. Liver biopsy should be performed and the diagnosis confirmed using scoring systems developed by the Autoimmune Hepatitis Group. Timely treatment with prednisone and other agents for autoimmune hepatitis is indicated, and can be lifesaving in acute liver failure. PMID: 27000683 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)



Infections complicating severe alcoholic hepatitis: Enterococcus species represent the most frequently identified pathogen.

Fri, 25 Mar 2016 06:03:02 +0100

Discussion Infections frequently complicate severe alcoholic hepatitis and affect survival. The high rate of Enterococcus infections suggests that commonly used antibiotics, such as cephalosporins and quinolones, may represent an ineffective choice of empiric antibiotic treatment for complicated AH. PMID: 27000534 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)

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Influence of Host and Viral Factors on Patients with Chronic Hepatitis C Virus Genotype 6 Treated with Pegylated Interferon and Ribavirin: A Systematic Review and Meta-Analysis

Fri, 25 Mar 2016 03:25:02 +0100

Conclusions: Treatment outcomes for HCV-6 patients are superior to those for HCV-1 patients and comparable to those of HCV-2 and HCV-3 patients, especially at 48 weeks. The level of fibrosis affects treatment outcome, but SVR rates are not significantly different between genders. IL28B and IFNL4 polymorphisms are not significantly associated with HCV-6 treatment outcome.Intervirology 2015;58:373-381 (Source: Intervirology)



Business Briefing: Gilead Ordered to Pay Merck $200 Million in Patent Dispute

Fri, 25 Mar 2016 02:22:05 +0100

A federal jury on Thursday ordered Gilead Sciences to pay for infringing two Merck patents related to a lucrative cure for hepatitis C. (Source: NYT Health)



Gilead ordered to pay Merck $200 million in hepatitis C drug patent dispute

Fri, 25 Mar 2016 02:01:35 +0100

SAN JOSE, Calif.,/NEW YORK (Reuters) - A federal jury on Thursday ordered Gilead Sciences Inc to pay Merck & Co $200 million in damages for infringing two Merck patents related to a lucrative cure for hepatitis C. (Source: Reuters: Health)



Management of hepatitis B reactivation in immunosuppressed patients: An update on current recommendations.

Fri, 25 Mar 2016 00:29:02 +0100

Authors: Bessone F, Dirchwolf M Abstract The proportion of hepatitis B virus (HBV) previously exposed patients who receive immunosuppressive treatment is usually very small. However, if these individuals are exposed to potent immunosuppressive compounds, the risk of HBV reactivation (HBVr) increases with the presence of hepatitis B surface antigen (HBsAg) in the serum. Chronic HBsAg carriers have a higher risk than those who have a total IgG anticore as the only marker of resolved/occult HBV disease. The loss of immune control in these patients may results in the reactivation of HBV replication within hepatocytes. Upon reconstitution of the immune system, infected hepatocytes are once again targeted and damaged by immune surveillance in an effort to clear the virus. There are diffe...



The mechanism of apoliprotein A1 down-regulated by Hepatitis B virus

Fri, 25 Mar 2016 00:00:00 +0100

Hepatitis B virus (HBV) infection correlated with the development of cirrhosis, liver failure and hepatocellular carcinoma (HCC), poses a huge health burden on the global community. However, the pathogenesis o... (Source: Lipids in Health and Disease)

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Atorvastatin and fluvastatin are associated with dose‐dependent reductions in cirrhosis and hepatocellular carcinoma, among patients with hepatitis C virus: Results from ERCHIVES

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion: In patients with chronic HCV, statin use was associated with a dose‐dependent reduction in incident cirrhosis and HCC. Atorvastatin and fluvastatin were associated with the most significant antifibrotic effects, compared with other statins. (Hepatology 2016) (Source: Hepatology)



SULF1/SULF2 reactivation during liver damage and tumour growth

Thu, 24 Mar 2016 23:00:00 +0100

Abstract Both SULF1 and SULF2 enzymes are undetectable in normal adult liver tissue despite their high level expression during foetal development. Most hepatocellular carcinomas unlike the normal adult liver, however, express variable levels of these enzymes with a small proportion not expressing either SULF1 or SULF2. SULF1 expression, however, is not restricted to only foetal and tumour tissues but is also abundant in liver tissues undergoing injury-induced tissue regeneration as we observed during fatty liver degeneration, chronic hepatitis and cirrhosis. Unlike SULF1, the level of SULF2 activation during injury-induced regeneration, however, is much lower when compared to foetal or tumour growth. Although a small fraction of liver tumours and some liver tumour cell lines can g...



Dynamics of in vivo hepatitis D virus infection

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion: Mathematical modeling of HDV infection can describe the complex interplay between this virus and HBV. Simulations suggest that HDV impacts on the feedback mechanisms that maintain cccDNA levels and that targeting these mechanisms may result in new therapeutic agents for both viruses. (Source: Journal of Theoretical Biology)



Performance of the New Aptima HCV Quant Dx Assay in Comparison to the Cobas TaqMan HCV2 Test for Use with the High Pure System in Detection and Quantification of Hepatitis C Virus RNA in Plasma or Serum [Virology]

Thu, 24 Mar 2016 23:00:00 +0100

Quantitating the level of hepatitis C virus (HCV) RNA is the standard of care for monitoring HCV-infected patients during treatment. The performances of commercially available assays differ for precision, limit of detection, and limit of quantitation (LOQ). Here, we compare the performance of the Hologic Aptima HCV Quant Dx assay (Aptima) to that of the Roche Cobas TaqMan HCV test, version 2.0, using the High Pure system (HPS/CTM), considered a reference assay since it has been used in trials defining clinical decision points in patient care. The assays' performance characteristics were assessed using HCV RNA reference panels and plasma/serum from chronically HCV-infected patients. The agreement between the assays for the 3 reference panels was good, with a difference in quantitation value...



Viruses, Vol. 8, Pages 91: Frequency of Natural Resistance within NS5a Replication Complex Domain in Hepatitis C Genotypes 1a, 1b: Possible Implication of Subtype-Specific Resistance Selection in Multiple Direct Acting Antivirals Drugs Combination Treatment

Thu, 24 Mar 2016 23:00:00 +0100

In conclusion, the pattern of subtype-specific resistance selection in the naturally occurring strains may guide the treatment option in association with direct acting antivirals (DAAs) targeting different regions, particularly in patients that are difficult to cure, such as those with advanced liver disease or individuals who have failed previous DAAs. (Source: Viruses)

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Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: Available online 24 March 2016 Source:Cell Reports Author(s): Myoung Sook Han, Tamera Barrett, Michael A. Brehm, Roger J. Davis The cJun NH2-terminal kinase (JNK) signaling pathway is required for the development of hepatitis and hepatocellular carcinoma. A role for JNK in liver parenchymal cells has been proposed, but more recent studies have implicated non-parenchymal liver cells as the relevant site of JNK signaling. Here, we tested the hypothesis that myeloid cells mediate this function of JNK. We show that mice with myeloid cell-specific JNK deficiency exhibit reduced hepatic inflammation and suppression of both hepatitis and hepatocellular carcinoma. These data identify myeloid cells as a site of pro-inflammatory signaling by JNK that can promote liver path...



Posttreatment Hepatitis B Surface Antigen Seroreversion: The Bane of Combination Therapy in Chronic Hepatitis B?

Thu, 24 Mar 2016 23:00:00 +0100

In this issue of Gastroenterology, Marcellin et al present the results of a landmark global randomized trial (Study 0149) comparing different regimes of pegylated interferon alfa-2a (PEG-IFN), tenofovir, or the combination for chronic hepatitis B.1 The primary endpoint of the study was defined as hepatitis B surface antigen (HBsAg) clearance, which is considered the closest outcome to cure in chronic hepatitis B. From their study, the authors conclude that 48 weeks of PEG-IFN plus tenofovir increases HBsAg loss compared with PEG-IFN alone. (Source: Gastroenterology)



Hepatitis C Disease Burden in the United States in the Era of Oral Direct‐Acting Antivirals

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions: HCV‐associated disease burden will still remain substantial in the era of oral DAAs. Increasing HCV screening and treatment capacity is essential to further decreasing HCV burden in the United States. This article is protected by copyright. All rights reserved. (Source: Hepatology)



Assessing the Therapeutic Potential of Lab‐Made Hepatocytes

Thu, 24 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Hepatology)



Thousands possibly exposed to hepatitis at heart clinic

Thu, 24 Mar 2016 22:58:15 +0100

Health department is notifying patients to get tested after cases of illness emerge (Source: Health News: CBSNews.com)

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Hepatitis infections apparently spread at stress test clinic

Thu, 24 Mar 2016 19:01:14 +0100

People in West Virginia who went in for a cardiac stress test got a letter recently that may cause them stress. (Source: CNN.com - Health)



Committee Opinion No. 661: Integrating Immunizations Into Practice.

Thu, 24 Mar 2016 18:43:02 +0100

Authors: Abstract Immunization against vaccine-preventable diseases is an essential component of women's primary and preventive health care. Despite the importance of vaccination and clear guidance from public health agencies, rates of vaccination lag behind national goals. Obstetrician-gynecologists can play a major role in reducing morbidity and mortality from a range of vaccine-preventable diseases, including pertussis, influenza, human papillomavirus, and hepatitis. Given demonstrated vaccine efficacy and safety, and the large potential for prevention of many infectious diseases that affect adults, pregnant women, and newborns, obstetrician-gynecologists should include immunizations as an integral part of their practice. To do so, they must embrace their role as important sour...



Committee Opinion No. 661 Summary: Integrating Immunizations Into Practice.

Thu, 24 Mar 2016 18:43:02 +0100

Authors: Abstract Immunization against vaccine-preventable diseases is an essential component of women's primary and preventive health care. Despite the importance of vaccination and clear guidance from public health agencies, rates of vaccination lag behind national goals. Obstetrician-gynecologists can play a major role in reducing morbidity and mortality from a range of vaccine-preventable diseases, including pertussis, influenza, human papillomavirus, and hepatitis. Given demonstrated vaccine efficacy and safety, and the large potential for prevention of many infectious diseases that affect adults, pregnant women, and newborns, obstetrician-gynecologists should include immunizations as an integral part of their practice. To do so, they must embrace their role as important sour...



Incidence of Hepatocellular Carcinoma According to Hepatitis B Virus Genotype in Alaska Native People

Thu, 24 Mar 2016 16:13:21 +0100

ConclusionHBV genotype is independently associated with HCC risk. AN persons with genotypes A, C, and F are at higher risk compared with genotypes B or D.This article is protected by copyright. All rights reserved. (Source: Liver International)



Determinants of liver disease progression in children with chronic hepatitis C virus infection.

Thu, 24 Mar 2016 12:58:02 +0100

Authors: Pokorska-Śpiewak M, Kowalik-Mikołajewska B, Aniszewska M, Pluta M, Walewska-Zielecka B, Marczyńska M Abstract Histopathological features and determinants of liver disease progression were analyzed in 42 treatment-naïve children (mean age: 10.7 ±3.7) with chronic hepatitis C (14/42 infected vertically and 26/42 horizontally). Histopathological evaluation was performed according to Knodell's modified system. Predictors of necroinflammation and fibrosis were identified using linear regression analyses. Most children presented with mild necroinflammation and fibrosis (mean grade 4.3 ±2.7, mean staging 1.2 ±0.8), irrespective of the mode of transmission. Vertically infected children were younger than those infected horizontally (8.6 ±2.5 vs. 11.5 ±3.7 years, p = 0.02)....

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Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers

Thu, 24 Mar 2016 10:24:01 +0100

The Journal of Organic ChemistryDOI: 10.1021/acs.joc.6b00105 (Source: The Journal of Organic Chemistry)



Flares during long‐term entecavir therapy in chronic hepatitis B

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionThe incidence of ALT flares during ETV was low in this real‐life cohort. ETV can be safely continued in patients with host‐induced flares. Treatment adherence and drug resistance must be assessed in patients with virus‐induced flares. This article is protected by copyright. All rights reserved. (Source: Journal of Gastroenterology and Hepatology)



All‐oral daclatasvir plus asunaprevir for chronic HCV genotype 1b infection: a sub‐analysis in Asian patients from the HALLMARK DUAL study

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionsAll‐oral dual therapy with DCV+ASV resulted in high SVR rates and was well‐tolerated in Asian patients with HCV GT‐1b infection.This article is protected by copyright. All rights reserved. (Source: Liver International)



Treatment adherence and virological response rates in hepatitis C virus infected persons treated with sofosbuvir‐based regimens: results from ERCHIVES

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionsSofosbuvir‐based treatment regimens are highly effective in achieving SVR12. This efficacy is not significantly affected when treated persons receive less than a full prescribed course of treatment. (Source: Liver International)