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MedWorm: Hematology News



MedWorm.com provides a medical RSS filtering service. Thousands of medical RSS feeds are combined and output via different filters. This feed contains the latest news in Hematology



Last Build Date: Thu, 22 Feb 2018 12:36:20 +0100

 



Impact of 70-Gene Signature Use on Chemo Decisions in BC Impact of 70-Gene Signature Use on Chemo Decisions in BC

Thu, 22 Feb 2018 05:14:49 +0100

Do results of gene-expression profiles change whether patients with ER-positive breast cancer receive adjuvant chemotherapy?Journal of Clinical Oncology (Source: Medscape Today Headlines)

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Medical News Today: What are lymphocytes and what are healthy levels to have?

Wed, 21 Feb 2018 19:00:00 +0100

Learn more about lymphocytes, a type of white blood cell. We look at their function, normal levels, and what happens if levels are too high or too low. (Source: Health News from Medical News Today)



' Unrealistic Expectations' for Cancer Survivorship Care Plans'Unrealistic Expectations' for Cancer Survivorship Care Plans

Wed, 21 Feb 2018 11:09:52 +0100

In the current literature, there is limited evidence of benefit from survivorship care plans. Researchers are calling for a shift in the focus of current research.Medscape Medical News (Source: Medscape Medical News Headlines)



Adjuvant Chemo Still Has Value Beyond 6 Months After Colon Cancer Surgery Adjuvant Chemo Still Has Value Beyond 6 Months After Colon Cancer Surgery

Wed, 21 Feb 2018 00:21:04 +0100

Adjuvant chemotherapy has benefit even if given 6 months or more after resection for stage III colon cancer, a new retrospective study suggests.Reuters Health Information (Source: Medscape General Surgery Headlines)



Too Old for Cancer Screening

Tue, 20 Feb 2018 22:35:03 +0100

(MedPage Today) -- Peter Ubel, MD, explains how to let older patients know tests won't help (Source: MedPage Today Hematology/Oncology)



Oncologist Critical in Motivating Cancer Survivors to Exercise Oncologist Critical in Motivating Cancer Survivors to Exercise

Tue, 20 Feb 2018 20:09:32 +0100

Oncologists need to play a larger role in discussing exercise with cancer survivors, and home-based exercise interventions offer advantages, say Australian researchers.Medscape Medical News (Source: Medscape Medical News Headlines)

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Suicide Among Cancer Survivors -- Highest Risk in HNC Suicide Among Cancer Survivors -- Highest Risk in HNC

Tue, 20 Feb 2018 11:51:33 +0100

Compared to all other cancer types, with one exception, the risk for suicide is significantly higher among survivors of head and neck cancer (HNC).Medscape Medical News (Source: Medscape Medical News Headlines)



Celiac Disease Associated With Aplastic Anemia in a 6-Year-Old Celiac Disease Associated With Aplastic Anemia in a 6-Year-Old

Tue, 20 Feb 2018 06:14:47 +0100

Many hematological disorders have been associated with celiac disease. This case represents the fourth associated with aplastic anemia in children--might it be more common than thought?Journal of Medical Case Reports (Source: Medscape Today Headlines)



Parotid swelling after Russell's viper envenomation: an unusual and poor prognostic sign - Sasidaran MN, Samuel SP, ChinnaRaju S, Antonysamy M, Bulfone TC, Lewin MR.

Mon, 19 Feb 2018 18:03:30 +0100

Parotid swelling, an unusual and poorly understood sign, is associated with poor prognosis in the setting of Russell's viper envenomation. The large, aggressive Russell's viper is one of the most deadly snakes causing severe hematological and neurological ... (Source: SafetyLit)



Exercise Improves Range of Motion After Lymph Node Surgery Exercise Improves Range of Motion After Lymph Node Surgery

Mon, 19 Feb 2018 13:11:29 +0100

Exercise plus education improves arm mobility after lymph node dissection faster than does education alone, especially in the arm affected by the dissection.Medscape Medical News (Source: Medscape Medical News Headlines)



Exercise Benefits Cancer Patients Even 4 Years Later Exercise Benefits Cancer Patients Even 4 Years Later

Mon, 19 Feb 2018 11:09:43 +0100

A long-term follow-up showed that an exercise program conducted during active treatment continues to confer benefits even 4 years later.Medscape Medical News (Source: Medscape Medical News Headlines)

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LEDs and Breast Cancer: That's Improbable!

Sun, 18 Feb 2018 14:35:03 +0100

(MedPage Today) -- Also, flammable hand rubs (Source: MedPage Today Hematology/Oncology)



FDA OKs Durvalumab (Imfinzi) for Reducing Risk for NSCLC Progression FDA OKs Durvalumab (Imfinzi) for Reducing Risk for NSCLC Progression

Sat, 17 Feb 2018 00:48:15 +0100

The immunotherapy becomes the first treatment approved to reduce the risk for progression in hard-to-treat stage III non-small cell lung cancer.FDA Approvals (Source: Medscape Medical News Headlines)



FDA OKs Durvalumab for Reducing Risk for NSCLC Progression FDA OKs Durvalumab for Reducing Risk for NSCLC Progression

Fri, 16 Feb 2018 23:58:17 +0100

The immunotherapy becomes the first treatment approved to reduce the risk for progression in hard-to-treat stage III non-small cell lung cancer.FDA Approvals (Source: Medscape Medical News Headlines)



Breast MRIs May Lead to More Biopsies That Catch Fewer Cancers Breast MRIs May Lead to More Biopsies That Catch Fewer Cancers

Fri, 16 Feb 2018 21:58:42 +0100

Women who get magnetic resonance imaging (MRI) screening tests for breast cancer are more likely to get invasive surgical biopsies to look for tumors than women who just get screening mammograms, a U.S. study suggests.Reuters Health Information (Source: Medscape Pathology Headlines)



Feb 16, 2018 This Week in Cardiology Feb 16, 2018 This Week in Cardiology

Fri, 16 Feb 2018 21:10:11 +0100

ICD use in patients with CKD, PFO and peri-operative stroke, LV assist devices, guideline-directed medical therapy after revascularization, and upcoming trials in 2018 are discussed in this week's podcast.theheart.org on Medscape (Source: Medscape Today Headlines)

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' Really Durable Benefit' Emerging With Bladder Cancer ImmunoTx'Really Durable Benefit' Emerging With Bladder Cancer ImmunoTx

Fri, 16 Feb 2018 13:13:26 +0100

Overall survival curves in cancer treatment trials typically go down with time. It's a big deal when survival stabilizes and a flat'tail'emerges as patients remain alive much longer.Medscape Medical News (Source: Medscape Today Headlines)



Intriguing: Better Survival in Melanoma in Obese Men Intriguing: Better Survival in Melanoma in Obese Men

Fri, 16 Feb 2018 10:10:33 +0100

Observations across cohorts of patients treated for metastatic melanoma have led to an intriguing conclusion: survival is better in obese patients, but only for men.Medscape Medical News (Source: Medscape Medical News Headlines)



RT and Targeted Therapy or Checkpoint Blockade in Brain Mets RT and Targeted Therapy or Checkpoint Blockade in Brain Mets

Fri, 16 Feb 2018 05:15:15 +0100

While more research is needed, most available studies find no relevant toxicity associated with the combination of radiotherapy and targeted therapy or immune checkpoint blockade for management of brain metastases.Annals of Oncology (Source: Medscape Today Headlines)



First Report of Parkinsonism Associated With Indoximod First Report of Parkinsonism Associated With Indoximod

Fri, 16 Feb 2018 05:15:15 +0100

Learn about a case of Parkinsonism likely associated with indoximod, an indoleamine 2,3-dioxygenase inhibitor.Journal of Global Oncology (Source: Medscape Today Headlines)



UCLA scientists receive $7.7 million grant to study HIV recurrence

Fri, 16 Feb 2018 00:07:06 +0100

The virus that causes AIDS is known to hide in certain rare cells. When people with HIV stop taking their medications, the virus can re-emerge and multiply, or “rebound,” from those hiding places. To better combat HIV, scientists have been working to understand how and why the virus re-emerges.“It’s the resurrection of virus that you couldn’t see in the body before,” said Jerome Zack, professor of medicine and chair of the UCLA department of microbiology, immunology and molecular genetics at the David Geffen School of Medicine at UCLA. Zack, who is director of the  UCLA Center for AIDS Research, and colleagues recently received a grant from the National Institute of Allergy and Infectious Diseases called “Defining Factors Controlling HIV Rebound.” The five-year, $7.7 mill...

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Physical Therapy Improves Arm Mobility After Lymph Node Dissection Physical Therapy Improves Arm Mobility After Lymph Node Dissection

Thu, 15 Feb 2018 21:46:44 +0100

Guided exercise with a physical therapist after breast-cancer surgery to remove lymphatic tissue helps women quickly regain full range of arm motion, new research shows.Reuters Health Information (Source: Medscape Pathology Headlines)



Overlooked Biomarker May Predict Cancer Immunotherapy Response Overlooked Biomarker May Predict Cancer Immunotherapy Response

Thu, 15 Feb 2018 20:58:01 +0100

Dr David Kerr on data showing that tumors with extensive aneuploidy may not benefit as much from immune checkpoint blockade.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)



Beyond APHINITY: What Now After Pivotal Breast Cancer Trial? Beyond APHINITY: What Now After Pivotal Breast Cancer Trial?

Thu, 15 Feb 2018 19:19:03 +0100

Dr Kathy Miller speaks with APHINITY's principal investigator about whether survival in HER2+ disease can be pushed even further.Medscape Oncology (Source: Medscape Today Headlines)



Novel De-escalation Approach for HPV+ Head and Neck Cancer Novel De-escalation Approach for HPV+ Head and Neck Cancer

Thu, 15 Feb 2018 15:14:05 +0100

A study of a novel approach to de-escalating treatment for HPV-positive head and neck cancer shows excellent pathologic complete response and survival outcomes.Medscape Medical News (Source: Medscape Medical News Headlines)



Despite Need, Cancer Centers Don't Stock Sex Aids Despite Need, Cancer Centers Don't Stock Sex Aids

Thu, 15 Feb 2018 13:40:13 +0100

Low availability of therapeutic sexual aids at NCI-designated cancer centers limits patients'ability to deal with sexual dysfunction in a timely way.Medscape Medical News (Source: Medscape Medical News Headlines)

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Highly Processed Foods May Raise Overall Cancer Risk Highly Processed Foods May Raise Overall Cancer Risk

Thu, 15 Feb 2018 11:50:21 +0100

A large cohort study shows that a diet that includes a lot of ultraprocessed food loaded with sugar, salt, and fat was associated with an increased risk for cancer.Medscape Medical News (Source: Medscape Medical News Headlines)



FDA Approves Apalutamide for Nonmetastatic Prostate Cancer FDA Approves Apalutamide for Nonmetastatic Prostate Cancer

Wed, 14 Feb 2018 22:08:04 +0100

This is the first approved therapy for prostate cancer patients who have nonmetastatic, castration-resistant prostate cancer.FDA Approvals (Source: Medscape Medical News Headlines)



Web-Based Tool Motivates Teen Cancer Survivors to Exercise Web-Based Tool Motivates Teen Cancer Survivors to Exercise

Wed, 14 Feb 2018 21:39:45 +0100

A web-based interactive tool was successful in increasing physical activity and improving related outcomes among adolescent childhood cancer survivors.Medscape Medical News (Source: Medscape Medical News Headlines)



For one early adopter, CAR T therapy means 18 months cancer-free and counting

Wed, 14 Feb 2018 18:55:00 +0100

For as long as he can remember, Josh Feldman has eagerly embraced the latest technology.Decades ago, his family was the first one on the block with a VCR. Years later, when television went hi-def, he acquired a big-screen TV and signed up for HD service.So after he was diagnosed with lymphoma, it was only natural that Feldman was driven to join clinical trials for a promising new treatment. He would become one of the first UCLA Health patients to receive CAR T therapy. When nothing else worked, the treatment beat back cancer and filled his life with new hope.“Years ago, while doing my own reading after my diagnosis, I learned about CAR T,” he said. “I envisioned that it was going to be groundbreaking, and I wanted to be part of it.”CAR T, which stands for “chimeric antigen recept...



Cabozantinib Active in RAI-Refractory Thyroid Cancer Cabozantinib Active in RAI-Refractory Thyroid Cancer

Wed, 14 Feb 2018 17:31:09 +0100

Cabozantinib has shown activity in the treatment of radioactive iodine-refractory differentiated thyroid carcinoma and could offer an option in addition to sorafenib and lenvatinib.Medscape Medical News (Source: Medscape Medical News Headlines)

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' No' to Ovarian Cancer Screening: Harms Outweigh Benefits'No' to Ovarian Cancer Screening: Harms Outweigh Benefits

Wed, 14 Feb 2018 17:11:32 +0100

Women who are not at high risk of developing ovarian cancer should not undergo routine screening, as it will not improve survival but may increase surgical complications, say US experts.Medscape Medical News (Source: Medscape Internal Medicine Headlines)



' Unprecedented' 73% Response Rate With Combo in Untreated RCC'Unprecedented' 73% Response Rate With Combo in Untreated RCC

Wed, 14 Feb 2018 16:39:56 +0100

The combination of an immunotherapy and a VEGF inhibitor for the initial treatment of advanced renal cell carcinoma yielded groundbreaking results. And it is not intolerably toxic.Medscape Medical News (Source: Medscape Medical News Headlines)



New Guidelines for Treating Checkpoint Inhibitor Toxicities New Guidelines for Treating Checkpoint Inhibitor Toxicities

Wed, 14 Feb 2018 15:58:51 +0100

ASCO and the NCCN have issued joint guidelines for treating toxicities associated with checkpoint inhibitor treatment.Medscape Medical News (Source: Medscape Medical News Headlines)



MABp1:'Clever' New Antibody Targeting Colorectal Cancer MABp1:'Clever' New Antibody Targeting Colorectal Cancer

Wed, 14 Feb 2018 15:50:18 +0100

A trial using MABp1, an antibody targeting interleukin 1 alpha, showed some benefit for patients with advanced colorectal cancer, but Dr Kerr thinks the clinical endpoint used was a'little soft. 'Medscape Oncology (Source: Medscape Today Headlines)



Radiomics in Precision Medicine for Lung Cancer Radiomics in Precision Medicine for Lung Cancer

Wed, 14 Feb 2018 05:14:52 +0100

Potential uses for radiomics in lung cancer include basic image segmentation, outcome modeling, and even the deciphering of genetic signatures.Translational Lung Cancer Research (Source: Medscape Today Headlines)

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Young People Often Face Delays in Cancer Diagnosis Young People Often Face Delays in Cancer Diagnosis

Tue, 13 Feb 2018 19:22:45 +0100

Adolescents and young adults may have long delays between the onset of cancer symptoms and being diagnosed, according to data from the UK.Reuters Health Information (Source: Medscape Medical News Headlines)



Imaging Agent Can Change Plans for Recurrent Prostate Cancer Imaging Agent Can Change Plans for Recurrent Prostate Cancer

Tue, 13 Feb 2018 15:10:08 +0100

Clinicians viewing scans using the imaging agent 18F-fluciclovine changed their management plans in 61% of cases of biochemical recurrence of prostate cancer.Medscape Medical News (Source: Medscape Medical News Headlines)



No Follow-up in More Than a Third of AYA Cancer Survivors No Follow-up in More Than a Third of AYA Cancer Survivors

Tue, 13 Feb 2018 13:58:53 +0100

A large proportion of adolescent and young adult (AYA) cancer survivors are not receiving follow-up care after the end of their active treatment.Medscape Medical News (Source: Medscape Medical News Headlines)



Response of High-Grade Gliomas to Checkpoint Inhibitors Response of High-Grade Gliomas to Checkpoint Inhibitors

Tue, 13 Feb 2018 05:14:48 +0100

How should MRI findings be used to assess response of high-grade gliomas to immunotherapy?Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)

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Local Immunotherapy of Cancer: Innovative Approaches Local Immunotherapy of Cancer: Innovative Approaches

Tue, 13 Feb 2018 05:02:54 +0100

Review the latest early research on intratumoral and intranodal immunotherapies.Journal of the National Cancer Institute (Source: Medscape Today Headlines)



Doctors Learn How to Talk to Patients About Dying Doctors Learn How to Talk to Patients About Dying

Mon, 12 Feb 2018 21:18:51 +0100

Clinicians can be so focused on fixing problems and saving lives that they often avoid talking to patients about their prognosis.Kaiser Health News (Source: Medscape Medical News Headlines)



Sickle Cell Disease: When to Transfuse Sickle Cell Disease: When to Transfuse

Mon, 12 Feb 2018 15:22:46 +0100

Know the appropriate indications for transfusion when transfusion is not indicated in patients with sickle cell disease.CDC Expert Commentary (Source: Medscape Today Headlines)



' Cinderella' Cancer Gets Trial With Fairy-tale Ending?'Cinderella' Cancer Gets Trial With Fairy-tale Ending?

Mon, 12 Feb 2018 15:11:45 +0100

Upper tract bladder cancer is a rare malignancy and as such is difficult to study in a phase 3 clinical trial. But a determined group of investigators pulled it off and appear to have changed practice.Medscape Medical News (Source: Medscape Medical News Headlines)



' Cinderella' Cancer Gets Trial With Fairy-tale Ending'Cinderella' Cancer Gets Trial With Fairy-tale Ending

Mon, 12 Feb 2018 15:02:19 +0100

Upper tract bladder cancer is a rare malignancy and as such is difficult to study in a phase 3 clinical trial. But a determined group of investigators pulled it off and appear to have changed practice.Medscape Medical News (Source: Medscape Today Headlines)

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Morning Break: Sketchy Coverage Denials; Presidential Valentine; UV Lamps for Flu

Mon, 12 Feb 2018 14:35:03 +0100

(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Hematology/Oncology)



Cancer Risk With Old Age Due to Immune System Decline? Cancer Risk With Old Age Due to Immune System Decline?

Mon, 12 Feb 2018 13:58:13 +0100

The increase in cancer incidence with age may be more closely related to age-related declines in the immune system than to the steady accumulation of genetic mutations, suggests a mathematical analysis.Medscape Medical News (Source: Medscape Medical News Headlines)



Prostate Cancer Immunotherapy Prostate Cancer Immunotherapy

Mon, 12 Feb 2018 05:08:15 +0100

Find out more about the current landscape for prostate cancer immunotherapy and learn about potential treatment strategies.Current Opinion in Urology (Source: Medscape Today Headlines)



Combo Therapy Highly Active in Untreated RCC

Mon, 12 Feb 2018 02:35:02 +0100

(MedPage Today) -- Objective responses with anti-VEGF/Anti-PD-1 pairing in three-fourths of patients (Source: MedPage Today Hematology/Oncology)



Duloxetine Cuts Joint Pain From Preventive Breast Cancer Tx (CME/CE)

Sun, 11 Feb 2018 16:35:02 +0100

(MedPage Today) -- Joint pain presents significant barrier to aromatase inhibitor adherence (Source: MedPage Today Hematology/Oncology)

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Survival Bump in Bladder Cancer with Keytruda

Sun, 11 Feb 2018 13:00:00 +0100

(MedPage Today) -- But no outcome advantage for Tecentriq in metastatic urothelial cancer (Source: MedPage Today Hematology/Oncology)



Xtandi Shows Potency in Advanced AR-Positive TNBC Breast Cancer (CME/CE)

Fri, 09 Feb 2018 20:35:02 +0100

(MedPage Today) -- Growing evidence suggests that enzalutamide may meet an unmet need in this patient population. (Source: MedPage Today Hematology/Oncology)



Selective Internal Radiotherapy Fails Again in mCRC Selective Internal Radiotherapy Fails Again in mCRC

Fri, 09 Feb 2018 15:53:28 +0100

Dr David Kerr on the latest setback from this once promising therapy.Medscape Oncology (Source: Medscape Today Headlines)



IDEA Trial Remakes Adjuvant Chemo in Colorectal Cancer IDEA Trial Remakes Adjuvant Chemo in Colorectal Cancer

Fri, 09 Feb 2018 15:44:49 +0100

Dr David Kerr on how one of the biggest studies at ASCO is already changing practice.Medscape Oncology (Source: Medscape Today Headlines)



Longer Endocrine Tx Better in Prostate Cancer

Fri, 09 Feb 2018 15:30:00 +0100

(MedPage Today) -- No survival advantage adding bisphosphonate in final RADAR results (Source: MedPage Today Hematology/Oncology)

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' Physician Trust' Tied to PSA Testing'Physician Trust' Tied to PSA Testing

Fri, 09 Feb 2018 14:57:54 +0100

In the era of shared decision making, a patient's trust in a physician plays a strong role in a controversial choice, such as PSA screening, a new study finds.Medscape Medical News (Source: Medscape Internal Medicine Headlines)



Next Steps for Immunotherapies, Cell Therapies in Oncology Next Steps for Immunotherapies, Cell Therapies in Oncology

Fri, 09 Feb 2018 14:38:44 +0100

At ESMO 2017, Drs Zimmermann, Svane, and Coukos discuss successes and setbacks in immuno-oncology.Medscape Oncology (Source: Medscape Today Headlines)



FDA Approves First Domestic Source of Medical Isotope FDA Approves First Domestic Source of Medical Isotope

Fri, 09 Feb 2018 10:04:05 +0100

An innovative, high-tech isotope separation platform for producing the widely used medical isotope technetium-99m from non-uranium-based molybdenum-99 has been granted FDA approval.FDA Approvals (Source: Medscape Medical News Headlines)



Medical News Today: Cognitive decline: Is low blood sodium a risk factor?

Fri, 09 Feb 2018 08:00:00 +0100

A new study suggests that low blood sodium levels — known as hyponatremia — may increase the risk of cognitive decline in older men by more than a third. (Source: Health News from Medical News Today)



Medical News Today: Low blood sodium could be a risk factor for cognitive decline

Fri, 09 Feb 2018 08:00:00 +0100

A new study suggests that low blood sodium levels — known as hyponatremia — may increase the risk of cognitive decline in older men by more than a third. (Source: Health News from Medical News Today)

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FDA Again Advises Against Morcellators for Fibroids FDA Again Advises Against Morcellators for Fibroids

Thu, 08 Feb 2018 22:14:16 +0100

The risk for uterine sarcoma being found in fibroids is too high, notes Dr Markman.Medscape Oncology (Source: Medscape Today Headlines)



Cancer Vaccine Works'Startlingly Well' in Mouse Model Cancer Vaccine Works'Startlingly Well' in Mouse Model

Thu, 08 Feb 2018 15:58:21 +0100

An experimental cancer vaccine that was injected directly into the tumor cured 87 of 90 mice, including some with spontaneous tumors.Medscape Medical News (Source: Medscape Medical News Headlines)



More Than Half of UK Docs Support Assisted Dying More Than Half of UK Docs Support Assisted Dying

Thu, 08 Feb 2018 11:58:38 +0100

The British Medical Association has long been opposed to assisted dying, but a recent poll found that 55% of physicians would support its becoming legal in defined circumstances.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)



Medical News Today: Sickle cell trait: What you need to know

Thu, 08 Feb 2018 08:00:00 +0100

Sickle cell trait is a blood disorder that affects the red blood cells. It usually does not cause symptoms, but can be passed on from parent to child. (Source: Health News from Medical News Today)



Depth of Response in PETHEMA/GEM Myeloma Trials Depth of Response in PETHEMA/GEM Myeloma Trials

Thu, 08 Feb 2018 05:14:49 +0100

According to this research, minimal residual disease negativity should be considered one of the most relevant clinical endpoints for some populations of patients with MM.Journal of Clinical Oncology (Source: Medscape Today Headlines)

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Depth of Response in NSCLC with Targeted or Immunotherapies Depth of Response in NSCLC with Targeted or Immunotherapies

Thu, 08 Feb 2018 05:14:49 +0100

Greater depth of response may be associated with overall survival and progression-free survival and could be considered as an additional outcome measure for clinical trials.Annals of Oncology (Source: Medscape Today Headlines)



Global hematology diagnostics market estimated to expand at a robust CAGR over 2021

Thu, 08 Feb 2018 05:00:00 +0100

(Health Affairs) Hematology includes various IVD technologies such as blood analysis, flow cytometry, immunodiagnostics, molecular diagnostics, hemostasis, histology, and cytology. (Source: EurekAlert! - Medicine and Health)



Gene Assay Informs Chemo Decision in Breast Cancer (CME/CE)

Thu, 08 Feb 2018 00:35:02 +0100

(MedPage Today) -- 10-year recurrence risk of 3.5% in low-risk, node-positive disease (Source: MedPage Today Hematology/Oncology)



Programming gene and engineered-cell therapies with synthetic biology

Thu, 08 Feb 2018 00:00:00 +0100

Gene and engineered-cell therapies promise to treat diseases by genetically modifying cells to carry out therapeutic tasks. Although the field has had some success in treating monogenic disorders and hematological malignancies, current approaches are limited to overexpression of one or a few transgenes, constraining the diseases that can be treated with this approach and leading to potential concerns over safety and efficacy. Synthetic gene networks can regulate the dosage, timing, and localization of gene expression and therapeutic activity in response to small molecules and disease biomarkers. Such "programmable" gene and engineered-cell therapies will provide new interventions for incurable or difficult-to-treat diseases. (Source: ScienceNOW)



Trastuzumab Biosimilar Equivalent in Early HER2+ Breast CA Tx (CME/CE)

Wed, 07 Feb 2018 18:30:00 +0100

(MedPage Today) -- Ratio of breast pathologic complete response rate 10% higher with SB3 (Source: MedPage Today Hematology/Oncology)

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Exercise Before Halves Problems After Lung Cancer Surgery Exercise Before Halves Problems After Lung Cancer Surgery

Wed, 07 Feb 2018 18:16:13 +0100

Exercising before surgery reduced complications and length of hospitalization in patients with lung cancer but had little to no effect in other cancer types.Medscape Medical News (Source: Medscape Medical News Headlines)



Docetaxel for Prostate Cancer:'Win-Win-Win'Docetaxel for Prostate Cancer:'Win-Win-Win '

Wed, 07 Feb 2018 16:07:02 +0100

In both metastatic and nonmetastatic patients, the chemotherapy improved three important outcomes compared with previous standard of care.Medscape Medical News (Source: Medscape Medical News Headlines)



Representation of Minorities and Women in Oncology Trials Representation of Minorities and Women in Oncology Trials

Wed, 07 Feb 2018 05:14:59 +0100

Do clinical trials in oncology adequately represent the US population with cancer?Journal of Oncology Practice (Source: Medscape Today Headlines)



Tumor Biomarkers in Lung Cancer for Detection and Treatment Tumor Biomarkers in Lung Cancer for Detection and Treatment

Wed, 07 Feb 2018 05:06:45 +0100

Review the roles of circulating tumor cells, circulating tumor DNA, microRNA and other biomarkers for lung cancer management.Translational Lung Cancer Research (Source: Medscape Today Headlines)



FDA Expands Indication for Anemia Drug Feraheme FDA Expands Indication for Anemia Drug Feraheme

Wed, 07 Feb 2018 00:49:27 +0100

Ferumoxytol injection is now indicated for all eligible adults with iron deficiency anemia who have failed to respond to oral iron.FDA Approvals (Source: Medscape Medical News Headlines)

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Combo Bests Targeted Agent in mRCC

Wed, 07 Feb 2018 00:35:02 +0100

(MedPage Today) -- Improved PFS with first-line atezolizumab and bevacizumab pairing (Source: MedPage Today Hematology/Oncology)



An Exceptional Case: IL-17 and Immune Checkpoint Inhibition An Exceptional Case: IL-17 and Immune Checkpoint Inhibition

Tue, 06 Feb 2018 20:43:35 +0100

A case report suggests that IL-17 plays an important role in immune checkpoint inhibition, argues Dr David Kerr.Medscape Oncology (Source: Medscape Today Headlines)



Largest Animal Study of Cell Phone Radiation and Cancer Risk Largest Animal Study of Cell Phone Radiation and Cancer Risk

Tue, 06 Feb 2018 19:10:35 +0100

Data from the long-awaited federal toxicology study found that male rats were the most susceptible to the effects of high doses of radiofrequency radiation.Medscape Medical News (Source: Medscape Medical News Headlines)



Bladder Cancer: Model Predicts Survival After Immunotherapy Bladder Cancer: Model Predicts Survival After Immunotherapy

Tue, 06 Feb 2018 16:42:15 +0100

A prognostic model based on six readily available clinical factors can help predict overall survival in patients with advanced bladder cancer receiving immunotherapy.Medscape Medical News (Source: Medscape Medical News Headlines)



Infection Prophylaxis, Immune Therapies Lead ASH Myeloma Data Infection Prophylaxis, Immune Therapies Lead ASH Myeloma Data

Tue, 06 Feb 2018 13:54:33 +0100

Dr S. Vincent Rajkumar discusses the most promising new treatments reported for multiple stages of myeloma at this year's ASH meeting.Medscape Oncology (Source: Medscape Today Headlines)

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Supplements and Chemotherapy-Induced Peripheral Neuropathy Supplements and Chemotherapy-Induced Peripheral Neuropathy

Tue, 06 Feb 2018 05:14:48 +0100

Do multivitamins mitigate development of chemotherapy-induced peripheral neuropathy?Journal of the National Cancer Institute (Source: Medscape Today Headlines)



Apalutamide Slows Metastasis in Prostate Cancer

Tue, 06 Feb 2018 02:35:02 +0100

(MedPage Today) -- Two-year delay in metastatic progression with apalutamide (Source: MedPage Today Hematology/Oncology)



Support for Upfront Immunotherapy in Advanced Renal Cell Cancer Support for Upfront Immunotherapy in Advanced Renal Cell Cancer

Mon, 05 Feb 2018 22:53:25 +0100

Atezolizumab plus bevacizumab improves progression-free survival with greater tolerability than standard sunitinib in advanced kidney cancer in a randomized controlled trial.Medscape Medical News (Source: Medscape Medical News Headlines)



' Finally, Real Promise' for Prostate Cancers With No Therapy'Finally, Real Promise' for Prostate Cancers With No Therapy

Mon, 05 Feb 2018 22:00:52 +0100

Two drugs have demonstrated clinically significant improvements in delaying the onset of metastatic disease by more than 20 months.Medscape Medical News (Source: Medscape Medical News Headlines)



Hot Tea and Increased Risk for Esophageal Cancer Hot Tea and Increased Risk for Esophageal Cancer

Mon, 05 Feb 2018 22:00:26 +0100

Researchers report a fivefold increased risk for esophageal cancer when hot tea aficionados smoke or drink alcohol every day.Medscape Medical News (Source: Medscape Medical News Headlines)

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Bacteria Identified as Oncogenic Drivers in Heredity Cancer Bacteria Identified as Oncogenic Drivers in Heredity Cancer

Mon, 05 Feb 2018 18:12:22 +0100

Bacterial biofilms have been identified as key drivers in colon cancer formation in patients with familial adenomatous polyposis and potentially other forms of colorectal cancer.Medscape Medical News (Source: Medscape Medical News Headlines)



Bacteria Identified as Oncogenic Drivers in Hereditary Cancer Bacteria Identified as Oncogenic Drivers in Hereditary Cancer

Mon, 05 Feb 2018 18:10:36 +0100

Bacterial biofilms have been identified as key drivers in colon cancer formation in patients with familial adenomatous polyposis and potentially other forms of colorectal cancer.Medscape Medical News (Source: Medscape Medical News Headlines)



Winship Cancer Institute names director of new Center for Cancer Immunology

Mon, 05 Feb 2018 17:35:37 +0100

Emory University's Winship Cancer Institute named Madhav V. Dhodapkhar director of its new Center for Cancer Immunology Dhodapkhar is an expert in cancer immunology and translational immunotherapy. He joins Winship from Yale University School of Medicine, where he served as chief of hematology, the Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and professor of immunobiology for the past decade. He was also co-director of the Cancer Immunology Program at the Yale Cancer Center.  The… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)



What is the Difference Between an Association and a Syndrome?

Mon, 05 Feb 2018 00:06:48 +0100

Discussion VATER association was first described in the 1970s with additional congenital malformations being added to the association so it is most often called VACTERL association. It is a highly heterogeneous, overlapping condition estimated to occur in ~1/10,000-40,000 births. The cause is unknown. In animal models, some signaling pathway gene mutations have phenotypes of VACTERL association. Experts suggest that patients having at least 2 components should be further evaluated (at least 3 for diagnosis) for VACTERL and other diseases in its differential diagnosis. There are more than 30 syndromes, mutations and diseases that have components of the malformations in VACTERL association. Alagille syndrome , CHARGE Syndrome, Blackfan-Diamond anemia, Holt-Oram syndrome, and Caudal regressi...



No Reduced Toxicity for Proton Tx vs IMRT in NSCLC (CME/CE)

Sun, 04 Feb 2018 18:35:02 +0100

(MedPage Today) -- Study challenges assumptions about supposed superiority of proton therapy (Source: MedPage Today Hematology/Oncology)

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Active Surveillance OK For Non-Muscle Invasive Bladder Cancer (CME/CE)

Sat, 03 Feb 2018 18:35:02 +0100

(MedPage Today) -- Select patients with low risk of progression can avoid repeat surgeries (Source: MedPage Today Hematology/Oncology)



' Striking' Survival Benefit With Surgery for Esophageal Cancer'Striking' Survival Benefit With Surgery for Esophageal Cancer

Fri, 02 Feb 2018 20:52:01 +0100

Patients with esophageal cancer who opt out of surgery when it is recommended may not live as long as their peers who have surgery, according to research presented January 30 at the Society of Thoracic Surgeons annual meeting.Reuters Health Information (Source: Medscape General Surgery Headlines)



Tranexamic Acid Immediately After Vaginal Delivery Cuts Risk of PPH

Fri, 02 Feb 2018 20:35:02 +0100

(MedPage Today) -- Higher rates of nausea/vomiting, but not severe adverse events (Source: MedPage Today Hematology/Oncology)



CAR T-Cell Therapy Ups Survival in Adults with Relapsed B-ALL (CME/CE)

Fri, 02 Feb 2018 16:30:00 +0100

(MedPage Today) -- In phase I data, median PFS 13 months; 20 months with low disease burden (Source: MedPage Today Hematology/Oncology)



' Real World' CAR T Cells: Comparing and Using Approved Products'Real World' CAR T Cells: Comparing and Using Approved Products

Fri, 02 Feb 2018 16:21:08 +0100

Drs Perales and Pasquini discuss the rapidly advancing field of CAR T and how patient safety and choice can be managed during these unprecedented times.Medscape Oncology (Source: Medscape Today Headlines)

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Overprescribing Opioids After Surgery for Cancer Overprescribing Opioids After Surgery for Cancer

Fri, 02 Feb 2018 15:14:38 +0100

Oncologists need to counsel patients more actively about postoperative pain and work collaboratively in multidisciplinary teams to avoid overprescribing opioids, argues Dr Lidia Schapira.Medscape Oncology (Source: Medscape Today Headlines)



Good News, Bad News About Melanoma for US Whites Good News, Bad News About Melanoma for US Whites

Fri, 02 Feb 2018 13:20:37 +0100

In the latest melanoma incidence data, younger adults had decreased rates but older adults had a steady increase.'Older'begins at age 54 for men and age 44 for women.Medscape Medical News (Source: Medscape Medical News Headlines)



Predictors of Paclitaxel Neurotoxicity Predictors of Paclitaxel Neurotoxicity

Fri, 02 Feb 2018 05:04:33 +0100

A new study finds discordance between patient- and clinician-reported neurotoxicity associated with paclitaxel.Annals of Oncology (Source: Medscape Today Headlines)



Quiz: Molecular Risk Stratification in Acute Myeloid Leukemia

Thu, 01 Feb 2018 23:35:25 +0100

Test your knowledge in our latest quiz. (Source: CancerNetwork)