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MedWorm: Hematology



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Hematology



Last Build Date: Mon, 28 Mar 2016 16:30:26 +0100

 



Determination of an unrelated donor pool size for human leukocyte antigen-matched platelets in Brazil

Mon, 28 Mar 2016 14:30:05 +0100

Conclusion: The phenotypic diversity of the Brazilian population has probably made it more difficulty to find completely compatible donors. However, this heterogeneity seems to have facilitated finding donors when cross-reactive groups are accepted as proposed by the grading system of Duquesnoy. The results of this study may help to establish unrelated human leukocyte antigen-compatible platelet transfusions, a procedure not routinely performed in most Brazilian transfusion services. (Source: Revista Brasileira de Hematologia e Hemoterapia)

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Nutritional assessment as predictor of complications after hematopoietic stem cell transplantation

Mon, 28 Mar 2016 14:30:05 +0100

Conclusions: After hematopoietic stem cell transplantation, high catabolism was associated with longer length of hospital stay, the need of total parenteral nutrition and platelet and neutrophil engraftment times. Nutritional parameters were not associated with overall survival. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Erythropoietin reduces storage lesions and decreases apoptosis indices in blood bank red blood cells

Mon, 28 Mar 2016 14:30:05 +0100

Conclusions: Under standard blood bank conditions, an important proportion of red blood cells satisfy the criteria of apoptosis. Recombinant human erythropoietin beta seems to improve storage lesion parameters and mitigate apoptosis. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Relationship between pulmonary and cardiac abnormalities in sickle cell disease: implications for the management of patients

Mon, 28 Mar 2016 14:30:05 +0100

Conclusion: A significant interrelation between abnormalities of the pulmonary and cardiovascular systems was observed in sickle cell disease patients. Furthermore, the severity of the cardiopulmonary parameters among patients with sickle cell anemia was greater than that of patients with other sickle cell diseases. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Hematopoietic progenitor cell mobilization for autologous transplantation - a literature review

Mon, 28 Mar 2016 14:30:05 +0100

ABSTRACT The use of high-dose chemotherapy with autologous support of hematopoietic progenitor cells is an effective strategy to treat various hematologic neoplasms, such as non-Hodgkin lymphomas and multiple myeloma. Mobilized peripheral blood progenitor cells are the main source of support for autologous transplants, and collection of an adequate number of hematopoietic progenitor cells is a critical step in the autologous transplant procedure. Traditional strategies, based on the use of growth factors with or without chemotherapy, have limitations even when remobilizations are performed. Granulocyte colony-stimulating factor is the most widely used agent for progenitor cell mobilization. The association of plerixafor, a C-X-C Chemokine receptor type 4 (CXCR4) inhibitor, to granulocyte c...



Serum free light chain assays not total light chain assays are the standard of care to assess Monoclonal Gammopathies

Mon, 28 Mar 2016 14:30:05 +0100

Abstract The diagnosis of Multiple Myeloma is a challenge to the physician due to the non-specific symptoms (anemia, bone pain and recurrent infections) that are commonplace in the elderly population. However, early diagnosis is associated with less severe disease, including fewer patients presenting with acute renal injury, pathological fractures and severe anemia. Since 2006, the serum free light chain test Freelite® has been included alongside standard laboratory tests (serum and urine protein electrophoresis, and serum and urine immunofixation) as an aid in the identification of monoclonal proteins, which are a cornerstone for the diagnosis of Multiple Myeloma. The serum free light chain assay recognizes the light chain component of the immunoglobulin in its free form with high sensit...

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Modern techniques of magnetic resonance in the evaluation of primary central nervous system lymphoma: contributions to the diagnosis and differential diagnosis

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Hemolytic vascular inflammation: an update

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Guidelines on the treatment of acute myeloid leukemia: Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Hematological manifestations of human T lymphotropic virus type 1 infection: a possible association with autoimmune myelofibrosis

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



RHD*weak D type 38: a family study

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)

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A difficult case of angioimmunoblastic T-cell lymphoma to diagnose

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Systemic fungal infection by Histoplasma capsulatum: intracellular fungus in peripheral leukocytes

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



What is the adequate mononuclear cell content for selecting umbilical cord blood units for cryopreservation?

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Zika virus and its implication in transfusion safety

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Neutropenia and neutrophil‐to‐lymphocyte ratio in a healthy Korean population: race and sex should be considered

Mon, 28 Mar 2016 14:29:22 +0100

ConclusionOur data indicate that the normal range of absolute neutrophil counts should be adjusted and cutoff values for neutropenia should be re‐established according to sex and race. NLR and PLR cutoff values for disease evaluation should be established separately according to race and age. (Source: Clinical and Laboratory Haematology)

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Trends in primary central nervous system lymphoma incidence and survival in the U.S.

Mon, 28 Mar 2016 14:29:18 +0100

Summary It is suspected that primary central nervous system lymphoma (PCNSL) rates are increasing among immunocompetent people. We estimated PCNSL trends in incidence and survival among immunocompetent persons by excluding cases among human immunodeficiency virus (HIV)‐infected persons and transplant recipients. PCNSL data were derived from 10 Surveillance, Epidemiology and End Results (SEER) cancer registries (1992–2011). HIV‐infected cases had reported HIV infection or death due to HIV. Transplant recipient cases were estimated from the Transplant Cancer Match Study. We estimated PCNSL trends overall and among immunocompetent individuals, and survival by HIV status. A total of 4158 PCNSLs were diagnosed (36% HIV‐infected; 0·9% transplant recipients). HIV prevalence in PCNSL case...



The role of upfront autologous stem cell transplantation in high‐risk younger patients with primary central nervous system lymphoma

Sun, 27 Mar 2016 22:00:00 +0100

Upfront autologous stem cell transplantation (ASCT) has shown favourable outcome in patients with primary central nervous system lymphoma (PCNSL), but the role of risk‐adapted upfront ASCT consolidation has not been evaluated in PCNSL. As PCNSL patients with the International Extranodal Lymphoma Study Group (IELSG) prognostic score ≥2 or those who did not achieve complete response after two courses of induction chemotherapy (non‐CR1) have shown inferior outcomes, we retrospectively analysed the role of upfront ASCT in 66 high‐risk (IELSG ≥2 and/or non‐CR1) younger (age <65 years) immunocompetent PCNSL patients who achieved at least partial response after initial high‐dose methotrexate‐based chemotherapy. Nineteen patients who received upfront ASCT exhibited significantl...



The evolving indications for splenectomy

Sun, 27 Mar 2016 22:00:00 +0100

(Source: British Journal of Haematology)



The genetic landscape of paediatric de novo acute myeloid leukaemia as defined by single nucleotide polymorphism array and exon sequencing of 100 candidate genes

Sun, 27 Mar 2016 22:00:00 +0100

Cytogenetic analyses of a consecutive series of 67 paediatric (median age 8 years; range 0–17) de novo acute myeloid leukaemia (AML) patients revealed aberrations in 55 (82%) cases. The most common subgroups were KMT2A rearrangement (29%), normal karyotype (15%), RUNX1‐RUNX1T1 (10%), deletions of 5q, 7q and/or 17p (9%), myeloid leukaemia associated with Down syndrome (7%), PML‐RARA (7%) and CBFB‐MYH11 (5%). Single nucleotide polymorphism array (SNP‐A) analysis and exon sequencing of 100 genes, performed in 52 and 40 cases, respectively (39 overlapping), revealed ≥1 aberration in 89%; when adding cytogenetic data, this frequency increased to 98%. Uniparental isodisomies (UPIDs) were detected in 13% and copy number aberrations (CNAs) in 63% (median 2/case); three UPIDs and 22 CN...



Glycosylation pattern of anti‐platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia

Sun, 27 Mar 2016 22:00:00 +0100

Fetal or neonatal alloimmune thrombocytopenia (FNAIT) is a potentially life‐threatening disease where fetal platelets are destroyed by maternal anti‐platelet IgG alloantibodies. The clinical outcome varies from asymptomatic, to petechiae or intracranial haemorrhage, but no marker has shown reliable correlation with severity, making screening for FNAIT impractical and highly inefficient. We recently found IgG Fc‐glycosylation towards platelet and red blood cell antigens to be skewed towards decreased fucosylation, increased galactosylation and sialylation. The lowered core‐fucosylation increases the affinity of the pathogenic antibodies to FcγRIIIa and FcγRIIIb, and hence platelet destruction. Here we analysed the N‐linked glycans of human platelet antigen (HPA)‐1a specific Ig...

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Incidence and risk factors for Central Nervous System thrombosis in paediatric acute lymphoblastic leukaemia during intensive asparaginase treatment: a single‐centre cohort study

Sun, 27 Mar 2016 22:00:00 +0100

Summary Central Nervous System (CNS) thrombosis is a complication of acute lymphoblastic leukaemia (ALL) treatment that is potentially associated with significant morbidity and neurological sequelae. Its presumably multifactorial aetiology is poorly characterized. We conducted a single‐centre, retrospective cohort study on 346 ALL paediatric patients (1–16 years old) treated with asparaginase intensive Dana Farber Cancer Institute (DFCI) protocols from 1998 to 2011. The incidence, risk factors and outcome of CNS thrombosis were evaluated. CNS thrombosis occurred in 3·8% (13/346) of the patients (95% confidence interval 2·0–6·3%). Twelve events were diagnosed during intensification, all of which resolved within 2 weeks without neurological sequelae or significant impact in surviv...



Rituximab, bendamustine and lenalidomide in patients with aggressive B‐cell lymphoma not eligible for anthracycline‐based therapy or intensive salvage chemotherapy – SAKK 38/08

Sun, 27 Mar 2016 22:00:00 +0100

In conclusion, R‐BL can be considered a treatment option for elderly patients with treatment naïve or relapsed/refractory aggressive lymphoma not eligible for standard aggressive regimens. (Source: British Journal of Haematology)



Role of vitamin D receptor gene polymorphisms in aplastic anemia: a case–control study from China

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsVDR polymorphisms may contribute to susceptibility to AA and influence the severity and prognosis of AA in a Chinese population. (Source: Clinical and Laboratory Haematology)

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Validation of a molecular diagnostic assay for CALR exon 9 indels in myeloproliferative neoplasms: identification of coexisting JAK2 and CALR mutations and a novel 9 bp deletion in CALR

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsFragment analysis is an accurate and sensitive method for the detection of CALR indels. The novel 9 bp deletion is likely a germline variant. Consequence of coexisting JAK2 V617F and CALR mutations requires careful interpretation. (Source: Clinical and Laboratory Haematology)



Absolute lymphocyte count as a prognostic marker in newly diagnosed multiple myeloma patients

Sun, 27 Mar 2016 22:00:00 +0100

(Source: Clinical and Laboratory Haematology)



Evidence for multidimensional resilience in adult patients with transfusion‐dependent thalassemias: Is it more common than we think?

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionDespite the considerable demands of their illness, adult thalassemic patients appeared to be adapting well, demonstrating evidence of multidimensional resilience. (Source: Transfusion Medicine)



The Reasearch on the Anti-Fatigue Effect of Whey Protein Powder in Basketball Training.

Sun, 27 Mar 2016 08:04:02 +0100

Authors: Ronghui S Abstract In order to observe the effects of whey protein powder on hematological indexes of players majoring in physical education in the basketball training, the authors divided the players randomly into a control group and a nutrition group. Athletes complete the 30 minutes quantitative exercise using cycle ergometer respectively before the trial and after one month trial. Then we exsanguinated immediately after exercise, extracted heparin and measured hemoglobin, red blood cell count, hematocrit and mean corpuscular volume and other hematological indices. The results showed that after taking whey protein powder, the HB, RBC, HCT of nutrition group was significantly higher that the control group. This suggests that in high-intensity training, taking whey protei...



Cytomegalovirus Infection in Children after Bone Marrow Transplantation: Risk factors, Clinical aspects and Outcomes

Sat, 26 Mar 2016 23:00:00 +0100

Conclusions Antigenemia-guided pre-emptive strategy with ganciclovir was very affective and CMV reactivation tended not to affect the outcome in our study cohort. (Source: Pediatric Infectious Disease)

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Clinical trial designs to obtain marketing authorization of drugs for haematological malignancy in Japan, the EU and the US

Sat, 26 Mar 2016 23:00:00 +0100

This study aimed to examine such differences in haematological malignancy indications not only in applications for new molecular entity agents but also in supplemental applications for additional indications. A total of 101 haematological malignancy indications were examined for 58 drugs. Only 30 indications were approved by the regulatory agencies of all three regions with 25, 9 and 67 indications being first approved in Japan, the EU and the US, respectively. Regarding the 18 indications approved only in the US, 13 were approved based on results of single‐arm trials. The approval of all nine indications approved first in the EU was based on results of comparative trials. The primary endpoints were different between the EU and the US in 4 of 49 indications approved by both regulatory ag...



How we manage thrombotic microangiopathies in pregnancy

Sat, 26 Mar 2016 23:00:00 +0100

Summary Differentiation between the thrombotic microangiopathies (TMAs) that present in pregnancy may be clinically challenging, but is critical to ensure correct management because of the impact on fetal and maternal outcomes. Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are medical/obstetric emergencies that require specialist input, both at the time of acute diagnosis and follow‐up in subsequent pregnancies. Features of preeclampsia and HELLP syndrome (haemolysis, elevated liver enzymes, low platelets) may precede or be present in evolving TTP or aHUS. Clinicians need to be mindful of how a presumed diagnosis of a specific TMA in pregnancy may evolve and be prepared to frequently reassess signs and symptoms and revise the diagnosis and mana...



Targeting childhood, adolescent and young adult non‐Hodgkin lymphoma: therapeutic horizons

Sat, 26 Mar 2016 23:00:00 +0100

Summary Non‐Hodgkin lymphoma (NHL) is the third most common malignancy in children, adolescents and young adults (CAYA). NHL is a diverse set of diseases that arise at key regulatory checkpoints during B or T cell development in the bone marrow, germinal centre or thymus. While advances in the use of conventional cytotoxic agents have led to dramatic improvements in survival, these cures are associated with significant acute and long‐term toxicities. Moreover, the prognosis for CAYA patients with relapsed or refractory NHL remains dismal, with the vast majority dying of their disease. Thanks to a large number of candidate‐based biological studies, together with large‐scale sequencing efforts, there has been an explosion of knowledge regarding the molecular pathophysiology of B‐ a...



Levels of uninvolved immunoglobulins predict clinical status and progression‐free survival for multiple myeloma patients

Sat, 26 Mar 2016 23:00:00 +0100

In this study, we investigated the ability of the HevyLite (HLC) immunoassay to correlate with clinical status based on levels of involved and uninvolved antibodies. In our cohort of MM patients, we observed that significantly higher ratios and greater differences of involved HLC levels compared to uninvolved HLC levels correlated with a worse clinical status. Similarly, higher absolute levels of involved HLC antibodies and lower levels of uninvolved HLC antibodies also correlated with a worse clinical status and a shorter progression‐free survival. These findings suggest that the HLC assay is a useful and a promising tool for determining the clinical status and survival time for patients with multiple myeloma. (Source: British Journal of Haematology)



Longitudinal evaluation of cerebral white matter hyperintensities lesion volume in children with sickle cell disease

Sat, 26 Mar 2016 23:00:00 +0100

(Source: British Journal of Haematology)

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Predictors of renal function progression in adults with homozygous sickle cell disease

Sat, 26 Mar 2016 23:00:00 +0100

Summary Longitudinal studies of renal function may improve understanding of the pathophysiological mechanisms underlying sickle cell disease (SCD) nephropathy and may identify possible biological and clinical markers of renal function determined over time. Data from the Jamaica Sickle Cell Cohort Study (JSCCS) were extracted and the glomerular filtration rate (GFR) was estimated using the Chronic Kidney Disease Epidemiological and the SCD specific JSCCS‐GFR equations from all adulthood serum creatinine measurements in homozygous SS patients. The other dataset consisted of measured GFR at two times about 13 years apart. Linear mixed model (LMM) regression analyses were conducted to determine predictors of GFR and serum creatinine over time. 191 individuals with SS disease had 867 GFR est...



Frequency and characterization of known and novel RHD variant alleles in 37 782 Dutch D‐negative pregnant women

Sat, 26 Mar 2016 23:00:00 +0100

Summary To guide anti‐D prophylaxis, Dutch D‐ pregnant women are offered a quantitative fetal‐RHD‐genotyping assay to determine the RHD status of their fetus. This allowed us to determine the frequency of different maternal RHD variants in 37 782 serologically D‐ pregnant women. A variant allele is present in at least 0·96% of Dutch D‐ pregnant women The D‐ serology could be confirmed after further serological testing in only 54% of these women, which emphasizes the potential relevance of genotyping of blood donors. 43 different RHD variant alleles were detected, including 15 novel alleles (11 null‐, 2 partial D‐ and 2 DEL‐alleles). Of those novel null alleles, one allele contained a single missense mutation (RHD*443C>G) and one allele had a single amino acid delet...



Advances in understanding the pathogenesis of graft‐versus‐host disease

Sat, 26 Mar 2016 23:00:00 +0100

Summary Allogeneic haematopoietic stem cell transplantation (HCT) is a potent immunotherapy with curative potential for several haematological disorders. Overcoming the immunological barrier of acute graft‐versus‐host disease (GVHD) remains a fundamental impediment to expanding the efficacy of HCT. GVHD reflects a complex pathological interaction between the innate and adaptive immune systems of the host and donor. Over the past decade there has been a tremendous advancement in our understanding of the cellular and molecular underpinnings of this devastating disease. In this review, we cover several recently appreciated facets of GVHD pathogenesis including novel extracellular mediators of inflammation, immune subsets, intracellular signal transduction, post‐translation modifications...



FXIIa inhibitor rHA‐Infestin‐4: Safe thromboprotection in experimental venous, arterial and foreign surface‐induced thrombosis

Sat, 26 Mar 2016 23:00:00 +0100

This study aimed to further assess the antithrombotic efficacy of the activated factor XII (FXIIa) inhibitor, rHA‐Infestin‐4, in several thrombosis models. In mice, rHA‐Infestin‐4 decreased occlusion rates in the mechanically‐induced arterial (Folt's) and the FeCl3‐induced venous thrombosis model. rHA‐Infestin‐4 also protected from FeCl3‐induced arterial thrombosis and from stasis‐prompted venous thrombosis in rabbits. Furthermore, rHA‐Infestin‐4 prevented occlusion in the arterio‐venous shunt model in mice and rabbits where thrombosis was induced via a foreign surface. In contrast to heparin, the haemostatic capacity in rabbits was unaffected by rHA‐Infestin‐4. Using rodent and non‐rodent species, our data demonstrate that the FXIIa inhibitor rHA‐Infestin...



Issue Information ‐ Editorial Board

Sat, 26 Mar 2016 23:00:00 +0100

(Source: British Journal of Haematology)

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Issue Information ‐ TOC1

Sat, 26 Mar 2016 23:00:00 +0100

(Source: British Journal of Haematology)



Issue Information ‐ TOC2

Sat, 26 Mar 2016 23:00:00 +0100

(Source: British Journal of Haematology)



Issue Information ‐ Papers to be published in forthcoming issues

Sat, 26 Mar 2016 23:00:00 +0100

(Source: British Journal of Haematology)



Safety and tolerability of pomalidomide‐based regimens (pomalidomide‐carfilzomib‐dexamethasone with or without cyclophosphamide) in relapsed/refractory multiple myeloma and severe renal dysfunction: a case series

Sat, 26 Mar 2016 23:00:00 +0100

Abstract Renal dysfunction negatively impacts outcomes in patients with multiple myeloma (MM). Few treatment options are currently available for patients with MM and comorbid renal dysfunction, and as they are generally excluded from clinical trials, data on the use of immunomodulatory drugs in this population are scarce. In this paper, we describe a case series of five women with MM and severe renal dysfunction or dialysis dependency who were refractory to both bortezomib and either lenalidomide or thalidomide and were treated with full‐dose (4 mg) pomalidomide. As part of their treatment regimen, these patients also received carfilzomib and dexamethasone with or without cyclophosphamide. All five patients achieved at least a partial response to pomalidomide‐based therapy, which was...



Immunotherapy approaches to treat adult acute lymphoblastic leukemia.

Sat, 26 Mar 2016 18:56:02 +0100

Authors: Maino E, Bonifacio M, Scattolin AM, Bassan R Abstract Recent developments in immunotherapy are improving treatment results of B-precursor acute lymphoblastic leukemia. This advancement is promoted by new monoclonal antibodies such as inotuzumab ozogamicin, ofatumumab and blinatumomab, by rituximab, and by genetically engineered chimeric antigen receptor-modified T-cells. These treatments, variously targeting CD22, CD20 and CD19 antigens, yield unprecedented high rates of hematologic and molecular remissions even when used in monotherapy and in chemo-resistant or post-transplantation relapsed patients. Beside the encouraging results in relapsed/refractory disease, these agents may open a totally new era in the frontline management of this illness, redefining treatment stand...



Editorial Board

Sat, 26 Mar 2016 06:23:19 +0100

(Source: Clinical Lymphoma, Myeloma and Leukemia)



Table of Contents

Sat, 26 Mar 2016 06:23:19 +0100

(Source: Clinical Lymphoma, Myeloma and Leukemia)






Chemotherapy versus Hypomethylating Agents for the Treatment of Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndrome Following Allogeneic Stem Cell Transplant: A Retrospective Review

Fri, 25 Mar 2016 23:00:00 +0100

Allogeneic stem cell transplant (allo-SCT) is a potentially curative treatment for high risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). For patients with relapsed disease after transplant intensive chemotherapy followed by donor lymphocyte infusion (DLI) or a second allo-SCT may result in a durable response in some patients. High intensity chemotherapy and less aggressive therapy with hypomethylating agents (HA) with and without DLI are often used for post allo-SCT relapse. (Source: Biology of Blood and Marrow Transplantation)



Blastic plasmacytoid dendritic cell neoplasm: From the origin of the cell to targeted therapies; Review

Fri, 25 Mar 2016 23:00:00 +0100

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with an aggressive clinical course. It is grouped with acute myeloid leukemia-related precursor neoplasms in the 2008 World Health Organization classification. Most patients with BPDCN have skin lesions at diagnosis and subsequent or simultaneous involvement of the bone marrow, peripheral blood, and lymph nodes. Patients usually respond to initial chemotherapy but often relapse. Stem cell transplant may improve survival. (Source: Biology of Blood and Marrow Transplantation)



Arginine methyltransferases in normal and malignant hematopoiesis

Fri, 25 Mar 2016 23:00:00 +0100

Arginine methylation is an abundant covalent modification that regulates diverse cellular processes including transcription, translation, DNA repair, and RNA processing. The enzymes that catalyze these marks are known as the protein arginine methyltransferases (PRMTs), and they can generate asymmetric dimethyl arginine (Type I arginine methyltransferases), symmetric dimethylarginine (Type II arginine methyltransferases), or monomethyarginine (Type III arginine methyltransferases). The PRMTs are capable of modifying diverse substrates, from histone components to specific nuclear and cytoplasmic proteins. (Source: Experimental Hematology)



Cytokine polymorphisms in sickle cell disease and the relationship with cytokine expression

Fri, 25 Mar 2016 23:00:00 +0100

Sickle cell disease is a chronic inflammatory condition with elevated levels of inflammatory cytokines which may be regulated by genetic polymorphisms and could be associated to diverse disease presentations and to alloimmunization. The aim of this study was to evaluate Treg and Th17 cell frequencies, cytokine gene polymorphisms and their association with cytokine expression profile in SCD patients. For that purpose, we evaluated the IL4 intron3 VNTR (genotypes 1.1, 1.2, 2.2, 2.3), IL4-T590C>T, IL6-174G>C, TNFA-308G>A, IL10-819T>C, IL10-592A>C and IL10-1082A>G polymorphisms and their correlation with TGFB, IL4, IL6, IL10 gene expression in sickle cell patients. (Source: Experimental Hematology)



Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Aspergillosis in Non-Hematological Patients

Fri, 25 Mar 2016 23:00:00 +0100

The role of galactomannan (GM) in serum or bronchoalveolar lavage fluid (BALF) for the diagnosis of invasive pulmonary aspergillosis (IPA) has been extensively evaluated in hematological patients, however its performance in non-hematological patients is not well established. (Source: Journal of Infection)



FDG-PET/CT Accurately Detects Recurrence in Breast CancerFDG-PET/CT Accurately Detects Recurrence in Breast Cancer

Fri, 25 Mar 2016 19:13:57 +0100

18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) is accurate in diagnosing recurrence in women with suspected recurrent breast cancer, according to results of a study in Denmark. Reuters Health Information (Source: Medscape Medical News Headlines)



Ibrutinib for Lymphocytic Leukemia Prompts Skin and Nail ChangesIbrutinib for Lymphocytic Leukemia Prompts Skin and Nail Changes

Fri, 25 Mar 2016 18:56:24 +0100

Although generally well tolerated, ibrutinib, a Bruton tyrosine kinase inhibitor effective against chronic lymphocytic leukemia (CLL), may lead to nail and hair abnormalities, according to a new report. Reuters Health Information (Source: Medscape Medical News Headlines)

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Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Akl MR, Nagpal P, Ayoub NM, Tai B, Prabhu SA, Capac CM, Gliksman M, Goy A, Suh KS Abstract Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology. Mammalian FGF family members participate in multiple signaling pathways by binding to heparan sulfate and FGF receptors (FGFR) with varying affinities. FGF2 is the prototype member of the FGF family and interacts with its receptor to mediate receptor dimerization, phosphorylation, and activation of signaling pathways, such as Ras-MAPK and PI3K pathways. Excessive mitogenic signaling through the FGF/FGFR axis may induce carcinogenic effects by promoting cancer progression and increasing the angiogenic potential, which can lead to metastatic tumor phenotypes. Dysregulated FGF/FGFR signaling is associat...



Gene Test Helped Docs Plan Breast Ca Therapy (CME/CE)

Fri, 25 Mar 2016 16:09:25 +0100

(MedPage Today) -- Recurrence Score assay prognostic for multiple outcomes (Source: MedPage Today Hematology/Oncology)



PET/CT Cuts Dissections Not Survival in Advanced Head and Neck CA (CME/CE)

Fri, 25 Mar 2016 15:00:19 +0100

(MedPage Today) -- Little difference seen in 2-year mortality, but costs lower (Source: MedPage Today Hematology/Oncology)



Second Malignancies After Radiotherapy for Prostate CancerSecond Malignancies After Radiotherapy for Prostate Cancer

Fri, 25 Mar 2016 14:34:21 +0100

Might irradiation of the prostate contribute to secondary cancers of other organs, such as bladder, colon, lung, and rectum? British Medical Journal (Source: Medscape Radiology Headlines)



Upregulation of EGFR Signaling in FGFR1-driven Breast CancerUpregulation of EGFR Signaling in FGFR1-driven Breast Cancer

Fri, 25 Mar 2016 12:34:28 +0100

New research unveils mechanisms driving tumor recurrence in breast cancer. Breast Cancer Research (Source: Medscape Today Headlines)



Treating Melanoma Brain Mets With Radiation and NivolumabTreating Melanoma Brain Mets With Radiation and Nivolumab

Fri, 25 Mar 2016 12:34:28 +0100

Is stereotactic radiation to melanoma brain metastases tolerated well in patients who received nivolumab? Annals of Oncology (Source: Medscape Today Headlines)



Aims and Scope

Fri, 25 Mar 2016 11:25:52 +0100

(Source: Transfusion Medicine Reviews)



Contents

Fri, 25 Mar 2016 11:25:52 +0100

(Source: Transfusion Medicine Reviews)

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Editorial Board

Fri, 25 Mar 2016 11:25:52 +0100

(Source: Transfusion Medicine Reviews)



Title page

Fri, 25 Mar 2016 11:25:52 +0100

(Source: Transfusion Medicine Reviews)



Masthead

Fri, 25 Mar 2016 11:25:52 +0100

(Source: Transfusion Medicine Reviews)



Successful renal transplantation in a patient with cold agglutinin disease

Fri, 25 Mar 2016 11:25:38 +0100

Cold agglutinin disease is a rare cause of acute graft loss after renal transplantation. A 71‐year‐old female with end stage renal failure was diagnosed to have cold agglutinin disease when investigated for recurrent clotting of hemodialysis circuits. Kidney transplantation was a major challenge due to unavoidable exposure of the transplant kidney to cold temperatures. Large volume plasma exchange given pre‐transplant and infusion of warm saline prior to anastomosis resulted in successful renal transplantation with good graft function despite initial delayed graft function. This challenging case illustrates the complete removal of cold agglutinin antibodies with therapeutic large volume plasma exchange. J. Clin. Apheresis, 2016. © 2016 Wiley Periodicals, Inc. (Source: Journal of Cli...



Correction of refractory thrombocytopenia and anemia following withdrawal of extended release niacin

Fri, 25 Mar 2016 11:25:32 +0100

(Source: American Journal of Hematology)

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Growth, Nutrition, and Cytokine Response of Breast-fed Infants and Infants Fed Formula With Added Bovine Osteopontin

Fri, 25 Mar 2016 11:13:48 +0100

Conclusions: Addition of OPN to infant formula changes amino acid metabolism and cytokine responses of FF infants and makes them more similar to BF infants. The lower prevalence of pyrexia in the F130 infants than in F0 infants suggests that adding OPN may confer health benefits. (Source: Journal of Pediatric Gastroenterology and Nutrition)



Biochemical Markers of Bone Turnover in Patients with β-Thalassemia Major: A Single Center Study from Southern Pakistan.

Fri, 25 Mar 2016 08:47:02 +0100

Conclusions. Biochemical profile is significantly altered in patients with β-thalassemia major and bone associated biochemical abnormalities like hypocalcaemia, 25-OH vitamin D deficiency, and hypophosphatemia are not uncommon in Pakistani patients with thalassemia major. PMID: 27006658 [PubMed] (Source: Advances in Hematology)



Only Conservative Use of PSA Testing Is Cost-effectiveOnly Conservative Use of PSA Testing Is Cost-effective

Fri, 25 Mar 2016 08:42:39 +0100

Infrequent screening for prostate cancer and conservative referral for biopsy are the only cost-effective strategies for prostate cancer management. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)

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Immune thrombocytopenia after bee venom therapy: a case report

Fri, 25 Mar 2016 00:00:00 +0100

Immune thrombocytopenia (ITP) is a hematological disorder with an isolated decrease in number of circulating platelets. Bee venom therapy (BVT) is a form of alternative medicine. It is still being practiced in... (Source: BMC Complementary and Alternative Medicine)



TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy

Thu, 24 Mar 2016 23:00:00 +0100

TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy Leukemia advance online publication, March 25 2016. doi:10.1038/leu.2016.34 Authors: E Nievergall, J Reynolds, C H Kok, D B Watkins, M Biondo, S J Busfield, G Vairo, K Fuller, W N Erber, T Sadras, R Grose, D T Yeung, A F Lopez, D K Hiwase, T P Hughes & D L White (Source: Leukemia)



Pre- and post-transplant quantification of measurable (‘minimal’) residual disease via multiparameter flow cytometry in adult acute myeloid leukemia

Thu, 24 Mar 2016 23:00:00 +0100

Pre- and post-transplant quantification of measurable (‘minimal’) residual disease via multiparameter flow cytometry in adult acute myeloid leukemia Leukemia advance online publication, March 25 2016. doi:10.1038/leu.2016.46 Authors: Y Zhou, M Othus, D Araki, B L Wood, J P Radich, A B Halpern, M Mielcarek, E H Estey, F R Appelbaum & R B Walter (Source: Leukemia)



LG-362B targets PML-RARα and blocks ATRA resistance of acute promyelocytic leukemia

Thu, 24 Mar 2016 23:00:00 +0100

LG-362B targets PML-RARα and blocks ATRA resistance of acute promyelocytic leukemia Leukemia advance online publication, March 25 2016. doi:10.1038/leu.2016.50 Authors: X Wang, Q Lin, F Lv, N Liu, Y Xu, M Liu, Y Chen & Z Yi (Source: Leukemia)



Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis

Thu, 24 Mar 2016 23:00:00 +0100

Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis Leukemia advance online publication, March 25 2016. doi:10.1038/leu.2016.53 Authors: Y Gu, W Zheng, J Zhang, X Gan, X Ma, Z Meng, T Chen, X Lu, Z Wu, W Huang & R Xu (Source: Leukemia)

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Analysis of racial variations in disease characteristics, treatment patterns, and outcomes of patients with chronic lymphocytic leukemia

Thu, 24 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)



Autologous stem cell transplantation in first complete remission may not extend progression free survival in patients with peripheral T cell lymphomas

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion For PTCL patients achieving CR1 following CHOP‐like induction chemotherapy, ASCT does not appear to improve progression free survival compared to active observation. This finding should be confirmed in a larger, prospective study. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)



Transformation of a previously diagnosed diffuse large B‐cell lymphoma to plasmablastic lymphoma

Thu, 24 Mar 2016 23:00:00 +0100

(Source: American Journal of Hematology)

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Hypertensive disorders of pregnancy and subsequent risk of solid cancer—A nationwide cohort study

Thu, 24 Mar 2016 23:00:00 +0100

Women with hypertensive disorders of pregnancy (HDP) have higher levels of antiangiogenic growth factors during pregnancy than women with normotensive pregnancies. Since angiogenesis is necessary for solid cancer growth and spread, we hypothesized that women with a history of HDP might have a reduced risk of solid cancers (cancers other than lymphomas, hematologic cancers and nonmelanoma skin cancers) later in life. In a register‐based cohort study of 1.08 million women giving birth at least once between 1978 and 2011, we used Cox regression to estimate hazard ratios (HRs) comparing solid cancer rates for women with and without a history of HDP. In this cohort, 68,236 women (6.3%) had ≥1 pregnancy complicated by HDP and 42,236 women (3.9%) developed solid tumors during follow‐up. A h...



Mast cells in lymphomas

Thu, 24 Mar 2016 23:00:00 +0100

This article is focused on the role of mast cells in lymphoma progression and angiogenesis. Mast cells might be regarded in a future perspective as a new target for the adjuvant treatment of tumors, including lymphomas. (Source: Critical Reviews in Oncology Hematology)

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Inter-rater agreement between professional-rated and patient-rated scores of the Villalta scale for evaluation of the post-thrombotic syndrome

Thu, 24 Mar 2016 23:00:00 +0100

Within the two years following lower extremity deep vein thrombosis (DVT), between 35 and 56% of cases develop postthrombotic syndrome (PTS) [1–4]. PTS is characterized by eleven possible symptoms and signs, including pain, edema and venous ulcers [5]. PTS is reported to be moderate to severe in 3–10% of cases, but this can vary to a significant degree within patients during at least the first 2years after DVT [2]. Consequences of PTS include a reduction of quality of life (QoL) and associated patient and societal economic burdens [6]. (Source: Thrombosis Research)



Worldwide adherence to ACCP guidelines for thromboprophylaxis after major orthopedic surgery: A systematic review of the literature and meta-analysis

Thu, 24 Mar 2016 23:00:00 +0100

Increased risk of venous thromboembolism following major orthopedic surgery (MOS) is well described. The American Academy of Chest Physician (ACCP) has generated evidence-based recommendations for thromboprophylaxis; however, there is a gap between guidelines recommendations and clinical practice. The aim of this study is to compare worldwide adherence rates to the last 4 editions of ACCP guidelines for thromboprophylaxis after MOS. (Source: Thrombosis Research)



Flow cytometry defined cytoplasmic immunoglobulin index is a major prognostic factor for progression of asymptomatic monoclonal gammopathies to multiple myeloma (subset analysis of SWOG S0120)

Thu, 24 Mar 2016 23:00:00 +0100

Authors: X Papanikolaou, A Rosenthal, M Dhodapkar, J Epstein, R Khan, F van Rhee, Y Jethava, S Waheed, M Zangari, A Hoering, J Crowley, D Alapat, F Davies, G Morgan & B Barlogie (Source: Blood Cancer Journal)



Evolution in the treatment of multiple myeloma and impact on dialysis independence: data from a French cohort from 1999 to 2014

Thu, 24 Mar 2016 23:00:00 +0100

Authors: M Laforet, N Jourde-Chiche, F Haddad, M Sallee, A M Stoppa, P Brunet, B Dussol, S Burtey & B Gondouin (Source: Blood Cancer Journal)



Dose-adjusted EPOCH chemotherapy with bortezomib and raltegravir for human T-cell leukemia virus-associated adult T-cell leukemia lymphoma

Thu, 24 Mar 2016 23:00:00 +0100

Authors: L Ratner, D Rauch, H Abel, B Caruso, A Noy, S K Barta, S Parekh, J C Ramos, R Ambinder, A Phillips, J Harding, H H Baydoun, X Cheng & S Jacobson (Source: Blood Cancer Journal)

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Loss of RUNX1 function results in enhanced granulocyte-colony-stimulating factor-mediated mobilization

Thu, 24 Mar 2016 23:00:00 +0100

Authors: K Lam, A Muselman, R Du, M Yan, S Matsuura & D-E Zhang (Source: Blood Cancer Journal)



Dual-Drug Strategy Reduces Carpet of Polyps in FAP PatientsDual-Drug Strategy Reduces Carpet of Polyps in FAP Patients

Thu, 24 Mar 2016 18:32:31 +0100

Colon carpeted with polyps in FAP patients can be favorably affected with a novel dual-drug strategy that offers the first really tenable treatment for this condition. Medscape Medical News (Source: Medscape Pathology Headlines)



Hospice and ED Use in Cancer Patients With a Poor PrognosisHospice and ED Use in Cancer Patients With a Poor Prognosis

Thu, 24 Mar 2016 16:00:00 +0100

Does enrollment in hospice reduce emergency department visits? Journal of the American Geriatrics Society (Source: Medscape Today Headlines)



Fall in PSA Screening Resulting in More Advanced DiseaseFall in PSA Screening Resulting in More Advanced Disease

Thu, 24 Mar 2016 14:14:01 +0100

Early signs of delayed diagnoses and prediction of more to come. Medscape Medical News (Source: Medscape Medical News Headlines)



Gothenburg PSA Study Shows Impact of Screening CessationGothenburg PSA Study Shows Impact of Screening Cessation

Thu, 24 Mar 2016 14:12:44 +0100

The latest results from the Gothenburg trial of prostate cancer screening, which showed that PSA testing reduced mortality, are now out to 18 years. Medscape Medical News (Source: Medscape Medical News Headlines)

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A Man With CD10-Positive, CD34-Positive B-Cell ALL.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Wang ES PMID: 27007409 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



A Woman With CD19-Positive, B-Cell ALL.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Douer D PMID: 27007408 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



A Man With Pre-B-Cell, CD20-Negative ALL.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Jabbour EJ PMID: 27007407 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Novel Approaches for the Interim Management of Relapsed/Refractory Acute Lymphocytic Leukemia: Introduction.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Wang ES PMID: 27007406 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Current Options for Third-Line Treatment of Metastatic Colorectal Cancer: Discussion.

Thu, 24 Mar 2016 12:15:01 +0100

Discussion. Clin Adv Hematol Oncol. 2016 Mar;14 Suppl 3(3):13-15 Authors: Grothey A, Marshall JL, Seery TE PMID: 27007241 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)

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Management of Metastatic Colorectal Cancer in the Community-Based Setting.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Seery TE, Tran P PMID: 27007240 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Optimal Use of Regorafenib: Dosing Strategies and Patient Selection.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Grothey A PMID: 27007239 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)