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MedWorm: Anemia



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Anemia category.



Last Build Date: Tue, 22 Mar 2016 08:29:15 +0100

 



Low Vitamin D Levels Are Associated With an Adverse Clinical Outcome in Febrile Neutropenia

Tue, 22 Mar 2016 07:43:43 +0100

Aim: The aim of the study was to evaluate the levels of vitamin D in patients of aplastic anemia presenting with febrile neutropenia and its association with clinically important parameters. Materials and Methods: The 25-hydroxy vitamin D (25(OH)D) levels were measured in 35 patients of aplastic anemia with febrile neutropenia in the age group of 4 to 16 years. About 30 healthy children served as controls. Vitamin D deficiency was defined as 25(OH)D (Source: Journal of Pediatric Hematology Oncology)

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Iron Deficiency and Iron-deficiency Anemia in Toddlers Ages 18 to 36 Months: A Prospective Study

Tue, 22 Mar 2016 07:43:43 +0100

In young children, iron deficiency (ID)—the most common cause of anemia—may adversely affect long-term neurodevelopment and behavior. We prospectively evaluated the prevalence of ID and iron deficiency anemia (IDA) in 256 healthy 18- to 36-month-old children in Northern Israel. Complete blood count and ferritin evaluation were performed, and risk factors were assessed. Hemoglobin (Hgb) was compared with first-year routine screening. Complete data were obtained from 208 children: 56.2% were boys; the mean age was 26.1±5.27 months. A prevalence of 5.8% IDA, 16.3% ID without anemia, 9.6% anemia with normal ferritin, and 68.3% normal Hgb and ferritin was found. In nonanemic infants at 1 year of age (n=156), ID/IDA was found in 19.9%, and 12.8% became anemic at study evaluation. Despite ir...



Evans Syndrome Secondary to Common Variable Immune Deficiency

Tue, 22 Mar 2016 07:43:43 +0100

We report a case of severe Evans syndrome presenting as altered mental status, a rare presenting sign of the disease. This case highlights the difficulty in diagnosing Evans syndrome and provides a review of the literature and management strategies for treating the disorder. (Source: Journal of Pediatric Hematology Oncology)



Autoimmune Hemolytic Anemia in Children: Mayo Clinic Experience

Tue, 22 Mar 2016 07:43:43 +0100

We studied 35 pediatric patients with autoimmune hemolytic anemia seen at Mayo Clinic from 1994 to 2014. The median age was 10.0 years and 65.7% were males. Most had warm antibodies (80.0%) and some secondary to viral (14.3%) or autoimmune disorders (31.4%). Seven (20.0%) patients presented with Evans syndrome, 3 of whom also had common variable immunodeficiency. The median hemoglobin at diagnosis was 6.1 g/dL and 62.8% patients required red cell transfusions. The severity of anemia was worse among children below 10 years (median 5.5 vs. 7.0 g/dL, P=0.01). Steroid was the initial treatment for 88.5% patients, with overall response rate of 82.7% (68.5% complete, 14.2% partial) and median response duration of 10.7 months (range, 0.2 to 129.7+ mo). After median follow-up of 26.6 months, 8 (22...



Epstein-Barr Virus–related Posttransplant Lymphoproliferative Disorder in Children: A Single-institution Experience

Tue, 22 Mar 2016 07:43:43 +0100

We report 4 pediatric cases of biopsy-proven posttransplant lymphoproliferative disorder (PTLD) in the context of allogeneic hematopoietic stem cell transplantation (HSCT). All cases showed diffuse staining with latent membrane protein-1 in immunohistochemistry. The median age at transplant of 4 patients with PTLD was 10.1 years (range, 2.2 to 13.2 y). The median interval between HSCT and the diagnosis of PTLD was 5.5 months (range, 4 to 8 mo). All patients were treated with rituximab at dosage of 375 mg/m2 at weekly intervals. Reduction of immunosuppression was warranted in all cases. All patients survived with median follow-up duration of 27 months. Although PTLD has been rare following allogeneic HSCT, reduction of immunosuppression combined with rituximab yielded significant response r...



Identification and Clinical Characterization of Children With Benign Ethnic Neutropenia

Tue, 22 Mar 2016 07:43:43 +0100

Benign ethnic neutropenia (BEN) is an asymptomatic condition reported in adults of African and Middle Eastern descent. The clinical description in children is currently lacking. In our urban outpatient pediatric hematology clinic, the median neutrophil count of children with BEN was lower than previous reports in adults at 893×106 cells/L, but increased with older age. There was an equal male to female ratio and 24% of our BEN children reported ethnicities other than African or Middle Eastern. Children with BEN had a clinical course comparable with other healthy children including otherwise normal blood counts, except for mild anemia. (Source: Journal of Pediatric Hematology Oncology)

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FDA weighs dangers of faulty readings from blood clot monitors

Mon, 21 Mar 2016 17:39:44 +0100

The FDA is considering possible dangers from medical devices that monitor blood clotting producing false readings, according to a report from The Wall Street Journal. The FDA has tracked thousands of cases of malfunctions from such devices over the years, the WSJ reports. Deaths and serious injuries have been linked with the erroneous readings, due to the increased susceptibility of individuals on anticoagulant drugs to strokes and other dangerous events. The federal watchdog brought together a panel of experts to discuss “point of care” clotting monitors last Friday to try and analyze the extent of the problem and help encourage more accurate product development, the WSJ said. The paper reported that the FDA said “serious adverse events” appear to be “linked ...



Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer.

Mon, 21 Mar 2016 05:47:03 +0100

Authors: Jia M, Zhu M, Wang M, Sun M, Qian J, Ding F, Chang J, Wei Q Abstract The JNK and P38α pathways play a crucial role in tissue homeostasis, apoptosis and autophagy under genotoxic stresses, but it is unclear whether single nucleotide polymorphisms (SNPs) of genes in these pathways play a role in platinum-based chemotherapy-induced toxicities in patients with advanced non-small cell lung cancer (NSCLC). We genotyped 11 selected, independent, potentially functional SNPs of nine genes in the JNK and P38α pathways in 689 patients with advanced NSCLC treated with platinum-combination chemotherapy regimens. Associations between these SNPs and chemotherapy toxicities were tested in a discovery group of 345 patients and then validated in a replication group of 344 patients. In bot...



Fermented Goat’s Milk Consumption Improves Duodenal Expression of Iron Homeostasis Genes during Anemia Recovery

Mon, 21 Mar 2016 04:26:15 +0100

Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.6b00108 (Source: Journal of Agricultural and Food Chemistry)



Protein Energy Malnutrition Associates with Different Types of Hearing Impairments in Toddlers: Anemia Increases Cochlear Dysfunction

Mon, 21 Mar 2016 00:00:00 +0100

This work aimed To highlight a challenging asymptomatic problem which is early detection of hearing impairment in toddlers with protein energy malnutrition (PEM) as a neuro-cognitive effect of PEM on developing brain in relation to hemoglobin level (Source: International Journal of Pediatric Otorhinolaryngology)



Late effects in patients with Fanconi anemia following allogeneic hematopoietic stem cell transplantation from alternative donors

Mon, 21 Mar 2016 00:00:00 +0100

Authors: P Anur, D N Friedman, C Sklar, K Oeffinger, M Castiel, J Kearney, B Singh, S E Prockop, N A Kernan, A Scaradavou, R Kobos, K Curran, J Ruggiero, N Zakak, R J O'Reilly & F Boulad (Source: Bone Marrow Transplantation)

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Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels.

Sun, 20 Mar 2016 21:02:02 +0100

Conclusion. Although non-zidovudine therapy may be associated with macrocytosis (MCV > 95 fL), zidovudine therapy and ART naivety may not. Suboptimal level of vitamin B12 as measured by high UMMA though highest in ART-naïve subjects was common in all HIV-infected subjects. PMID: 26989408 [PubMed] (Source: Interdisciplinary Perspectives on Infectious Diseases)



Cutaneous Rosai-Dorfman Disease in a Patient with Human Immunodeficiency Virus.

Sun, 20 Mar 2016 01:46:01 +0100

We report an interesting case of cutaneous Rosai Dorfman disease in a patient with human immunodeficiency virus (HIV). PMID: 26990470 [PubMed - in process] (Source: Dermatol Online J)



Nawracające zakażenie układu moczowego jako pierwszy objaw choroby Leśniowskiego i Crohna

Sun, 20 Mar 2016 00:00:00 +0100

Publication date: Available online 18 March 2016 Source:Pediatria Polska Author(s): Maria Augustyn, Magdalena Silska-Dittmar, Jolanta Sołtysiak, Janusz Rataj, Jarosław Walkowiak, Danuta Ostalska-Nowicka, Jacek Zachwieja Crohn's disease belongs to the group of autoimmune diseases, known as inflammatory bowel disease. The inflammation may span the entire depth of the intestinal wall. In effect the typical complications of Crohn's disease can be the formation of fistulas: external (perianal, between the bowel and skin) and internal (between two loops of bowel, between the bowel and bladder, between the bowel and vagina). These complications may occur in about 30–40% of patients. The study describes a 17-year-old patient hospitalized for recurrent urinary tract infections. The fir...



Safety of two-year caloric restriction in non-obese healthy individuals.

Sat, 19 Mar 2016 17:51:03 +0100

CONCLUSIONS: Two-years of CR at levels achieved in CALERIE was safe and well tolerated. Close monitoring for excessive bone loss and anemia is important. PMID: 26992237 [PubMed - as supplied by publisher] (Source: Oncotarget)



Effect of recombinant human erythropoietin and doxorubicin in combination on the proliferation of MCF-7 and MDA-MB231 breast cancer cells.

Sat, 19 Mar 2016 16:30:04 +0100

Authors: Radwan EM, Abdullah R, Al-Qubaisi MS, El Zowalaty ME, Naadja SE, Alitheen NB, Omar AR Abstract Patients with cancer often exhibit signs of anemia as the result of the disease. Thus, cancer chemotherapies often include erythropoietin (EPO) in the regime to improve the survival rate of these patients. The aim of the present study was to determine the effect of EPO on doxorubicin-treated breast cancer cells. The cytotoxicity of doxorubicin alone or in combination with EPO against the MCF-7 and MDA-MB‑231 human breast cancer cells were determined using an MTT cell viability assay, neutral red (NR) uptake assay and lactate dehydrogenase (LDH) assay. The estimated half maximal inhibitory concentration values for doxorubicin and the combination of doxorubicin with EPO were betw...

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Malaria in cynomolgus monkeys used in toxicity studies in Japan.

Sat, 19 Mar 2016 14:30:02 +0100

Authors: Ohta E, Nagayama Y, Koyama N, Kakiuchi D, Hosokawa S Abstract Plasmodium spp. protozoa cause malaria and are known to infect humans and a variety of animal species including macaque monkeys. Here we report both our experience with malaria recrudescence in cynomolgus monkeys (Macaca fascicularis) in a toxicity study and the results of a survey on Plasmodium infection in cynomolgus monkeys imported to Japan for laboratory use. A cynomolgus monkey from the toxicity study presented with severe anemia and Plasmodium protozoa in erythrocytes on a thin blood smear and was subsequently diagnosed with symptomatic malaria. In this animal, congestion and accumulation of hemozoin (malaria pigment) in macrophages were noted in the enlarged and darkly discolored spleen. As a follow-up f...



Guideline for dialysate quality of Spanish Society of Nephrology (second edition, 2015).

Sat, 19 Mar 2016 12:52:02 +0100

Authors: Pérez-García R, García Maset R, Gonzalez Parra E, Solozábal Campos C, Ramírez Chamond R, Martín-Rabadán P, Sobrino Pérez PE, Gallego Pereira O, Dominguez J, de la Cueva Matute E, Ferllen R, Comisión de Expertos de la Sociedad Española de Nefrología para la creación de la Segunda Edición de la Guía de Gestión de Calidad del Líquido de Diálisis Abstract A Best Practice Guideline about Dialysis fluid purity was developed under the leadership of the Spanish Society of Nephrology in 2004. The second edition revised Guideline considered new evidences and International Standard. The Guideline has established recommendations for standards for preparing dialysate: water, concentrates and hemodialysis proportioning systems. This Guideline is based on the ISO13959, E...



Efficacy of the repellent N,N-diethyl-3-methyl-benzamide (DEET) against tabanid flies on horses evaluated in a field test in Switzerland

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: Available online 18 March 2016 Source:Veterinary Parasitology Author(s): C. Herholz, C. Kopp, M. Wenger, A. Mathis, S. Wägeli, N. Roth Female tabanid flies (Diptera: Tabanidae) can be a serious nuisance for horses because of their painful bites during blood feeding. They also play a primary role in mechanical transmission of a lentivirus causing Equine Infectious Anemia (EIA), a virus that has spread within Europe in recent years. According to the European law for products intended for use as a repellent on horses (recreational and sport horses), a field test is mandatory to demonstrate sufficient repellency of such a substance against the specific target fly species, but currently no agreed protocols are available for testing of potential repellents. The aim of ...



Analysis of risk factors and prevalence of haemoplasma infection in dogs

Sat, 19 Mar 2016 00:00:00 +0100

This study aimed to determine the prevalence and phylogeny of canine haemoplasma species in dogs from Nigeria and describe any risk factors for infection. Canine haemoplasma species-specific and generic haemoplasma qPCR assays were used. The species-specific qPCR assays found Mhc infection in 18 of 245 dogs (7.3%), and CMhp infection in only one dog (0.4%). The generic haemoplasma qPCR assays were positive in 44 of 245 (17.9%) dogs. Twenty-five dogs had discordant qPCR results in that they were generic haemoplasma qPCR positive but species-specific qPCR negative. Further evaluation of these dogs by 16S rDNA sequencing gave limited results but 5 were confirmed to be infected with non-haemoplasma species: 2 Anaplasma phagocytophilum, 1 Anaplasma ovis, 1 Serratia marcescens and 1 Aerococcus s...



Intensive chemoimmunotherapy and bilateral globe irradiation as initial therapy for primary intraocular lymphoma

Sat, 19 Mar 2016 00:00:00 +0100

Conclusions Combined modality treatment with R-MPV, binocular radiation, and high-dose cytarabine is effective with moderate toxicity. Both local and CNS relapses occur; however, the achievement of second and subsequent remissions is possible. (Source: Neuro-Oncology)

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Correlation of anemia status with worsening bowel damage as measured by Lémann Index in patients with Crohn's disease

Sat, 19 Mar 2016 00:00:00 +0100

There is evidence that anemia in Crohn's disease (CD) is a predictor of disease severity. (Source: Digestive and Liver Disease)



Anemia prevalence and hematologic findings in German geriatric inpatients – results of the prospective cross-sectional multicenter study “GeriAnaemie 2013”

Sat, 19 Mar 2016 00:00:00 +0100

Conclusion Anemia was mainly normocytic, mild and highly prevalent in this patient cohort, could not always be specified; multicausality was supposed; MCV appeared to be inappropriate for pathogenetical assignment of anemia subtypes in older patients. Further research in geriatric hematologic particularities is needed. (Source: European Geriatric Medicine)



Prenatal diagnosis of hemoglobinopathies in Tunisia: an 18 years of experience

Sat, 19 Mar 2016 00:00:00 +0100

ConclusionAlthough the good running of the PND, it covers only the Tunis city with low impact because it prevent apparition of only a mean of 7.3% of new cases. The reduced number of PND is not a technical inconvenience but rather a lack of a preventive program. (Source: Clinical and Laboratory Haematology)






Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study

Sat, 19 Mar 2016 00:00:00 +0100

We report the results from a cohort of patients with lymphoma or multiple myeloma (non-leukaemia cohort). Methods In this dose-escalation, open-label, phase 1 study, we recruited patients from seven university hospital centres (in France [four], Switzerland [one], UK [one], and Italy [one]). Adult patients with non-leukaemia haematological malignancies who had disease progression on standard therapies were eligible to participate. Patients were treated with oral OTX015 once a day continuously over five doses (10 mg, 20 mg, 40 mg, 80 mg, and 120 mg), using a conventional 3 + 3 design, with allowance for evaluation of alternative administration schedules. The primary endpoint was dose-limiting toxicity (DLT) in the first treatment cycle (21 days). Secondary objectives were to evaluate s...

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Evaluation of Anemia

Sat, 19 Mar 2016 00:00:00 +0100

Anemia is a common problem in primary care. Classification based on mean cell volume narrows the differential diagnosis and directs testing. A marked macrocytosis is characteristic of vitamin B12 and folate deficiencies, certain medications, and primary bone marrow disorders. The three most common causes of microcytic anemia are iron deficiency, thalassemia trait, and anemia of inflammation. Additional laboratory testing is required for diagnosis. Determination of the rate of development of anemia and examination of a blood smear may provide diagnostic clues to guide more specialized testing. Diagnosis of iron, vitamin B12, or folate deficiency mandates determination of the underlying cause. (Source: Obstetrics and Gynecology Clinics)



Anemia in type 2 diabetic patients and correlation with kidney function in a tertiary care sub-Saharan African hospital: a cross-sectional study

Sat, 19 Mar 2016 00:00:00 +0100

Anemia is common in diabetic patients and increases morbidity and mortality, but its burden has been less well characterized in sub-Saharan Africans. We determined the prevalence of anemia and investigated the... (Source: BMC Nephrology)



Prenatal diagnosis of hemoglobinopathies in Tunisia: an 18 years of experience.

Sat, 19 Mar 2016 00:00:00 +0100

CONCLUSION: Although the good running of the PND, it covers only the Tunis city with low impact because it prevent apparition of only a mean of 7.3% of new cases. The reduced number of PND is not a technical inconvenience but rather a lack of a preventive program. PMID: 26993054 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)



Diarrhea-associated hemolytic uremic syndrome with severe neurological manifestations treated with IgG depletion through immunoadsorption.

Sat, 19 Mar 2016 00:00:00 +0100

CONCLUSION: Delayed-onset neurological abnormalities may occur in diarrhea-associated HUS. Novel specific treatment options include IgG depletion through immunoadsorption. Severe clinical and imaging findings do not preclude a good outcome. PMID: 26995001 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)



Autoimmune Hemolytic Anemia Induced by Adalimumab.

Fri, 18 Mar 2016 23:15:02 +0100

Authors: Harada Y, Yamamoto H, Sato M, Kodaira M, Kono T PMID: 26984100 [PubMed - in process] (Source: Internal Medicine)

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Thrombocytopenia and Anemia with Anti-c-Mpl antibodies Effectively Treated with Cyclosporine in a Patient with Rheumatoid Arthritis and Chronic Renal Failure.

Fri, 18 Mar 2016 23:15:02 +0100

Authors: Hashimoto A, Kanisawa Y, Fujimi A, Nakajima C, Hayasaka N, Yamada S, Okuda T, Minami S, Yamauchi N, Iwasaki S, Suzuki A, Kato J Abstract A 61-year-old woman with rheumatoid arthritis who was undergoing hemodialysis for end-stage renal failure was transferred to our hospital due to severe thrombocytopenia and anemia. A bone marrow biopsy showed the complete absence of megakaryocytes and erythroblasts. Cyclosporine treatment resulted in the improvement of her megakaryocyte and erythroblast levels, and a decrease in her serum level of anti-c-Mpl (thrombopoietin receptor) antibodies. After this initial improvement, her anemia progressively worsened, despite the continuous administration of immunosuppressive therapy with cyclosporine. Her platelet and leukocyte counts remained ...



Autoimmune Hemolytic Anemia Triggered by Infection with Human Parvovirus B19 after Total Abdominal Colectomy for Ulcerative Colitis.

Fri, 18 Mar 2016 23:15:02 +0100

Authors: Iida T, Satoh S, Nakagaki S, Shimizu H, Kaneto H Abstract A 50-year-old man was admitted to our hospital for an adhesive ileus 14 years after total abdominal colectomy for ulcerative colitis (UC). The ileus decreased with conservative treatment, however, autoimmune hemolytic anemia (AIHA) was diagnosed due to worsening anemia, a positive direct Coombs test, low haptoglobin, high lactase dehydrogenase, reticulocytosis, and an increase in the erythroblastic series in a bone-marrow examination. Human parvovirus B19 (PV-B19) IgM and PV-B19 DNA were present, indicating the development of AIHA triggered by an infection with PV-B19. The patient is currently being monitored after spontaneous remission. This is the first report of UC after total abdominal colectomy complicated by A...



[Pernicious anaemia in a young patient: what is the best route of administration of vitammin B12?].

Fri, 18 Mar 2016 11:45:02 +0100

Authors: Gallego Muñoz C, Manzano Martín MV PMID: 26980173 [PubMed - in process] (Source: Farmacia Hospitalaria)



Laboratory use of hepcidin in renal transplant recipients.

Fri, 18 Mar 2016 03:28:02 +0100

Authors: Šimetić L, Zibar L Abstract Hepcidin is a small peptide with a critical role in cellular iron homeostasis, as it regulates utilization of stored iron and antimicrobial defense in inflammation (bacterial and fungal). Since it was isolated in 2000, and especially in the last decade, numerous studies aimed to evaluate the clinical use of plasma and urine hepcidin as a marker of anemia, especially anemia of chronic disease and post-transplant anemia (PTA). Hepcidin regulation is delicately tuned by two inflammatory pathways activated by interleukin-6 (IL-6) and bone morphogenic proteins (BMPs) and iron regulated pathway sensitive to circulating transferin-iron (TR-Fe) complex. BMP-mediated pathway and TR-Fe sensitive pathway seem to be connected by hemojuveline, a BMP co-fac...

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Idiopathic multicentric Castleman's disease: a systematic literature review

Fri, 18 Mar 2016 00:00:00 +0100

Publication date: Available online 17 March 2016 Source:The Lancet Haematology Author(s): Amy Y Liu, Christopher S Nabel, Brian S Finkelman, Jason R Ruth, Razelle Kurzrock, Frits van Rhee, Vera P Krymskaya, Dermot Kelleher, Arthur H Rubenstein, David C Fajgenbaum Background Multicentric Castleman's disease describes a group of poorly understood lymphoproliferative disorders driven by proinflammatory hypercytokinaemia. Patients have heterogeneous clinical features, characteristic lymph node histopathology, and often deadly multiple organ dysfunction. Human herpesvirus 8 (HHV8) causes multicentric Castleman's disease in immunosuppressed patients. The cause of HHV8-negative multicentric Castleman's disease is idiopathic; such cases are called idiopathic multicentric Castleman's di...



Handwashing and nail clipping reduce risk of intestinal parasite infection in school-age children

Fri, 18 Mar 2016 00:00:00 +0100

Commentary on: Mahmud MA, Spigt M, Bezabih AM, et al.. Efficacy of handwashing with soap and nail clipping on intestinal parasitic infections in school-aged children: a factorial cluster randomized controlled trial. PLoS Med 2015;12:e1001837. Implications for practice and research Simple, straightforward hygiene interventions can prevent parasitic infection/reinfection and anaemia among children in countries with limited resources. Although hand hygiene efficacy was demonstrated, further research is required about the effectiveness of hand hygiene interventions in a less controlled setting must still be assessed. Context Previous studies have highlighted the association between basic hygiene and childhood infections in developing countries,1 but no previous randomised controlled trials (RC...



Evaluation of Anemia

Fri, 18 Mar 2016 00:00:00 +0100

Publication date: Available online 18 March 2016 Source:Obstetrics and Gynecology Clinics of North America Author(s): Jody L. KujovichTeaser Anemia is a common problem in primary care. Classification based on mean cell volume narrows the differential diagnosis and directs testing. A marked macrocytosis is characteristic of vitamin B12 and folate deficiencies, certain medications, and primary bone marrow disorders. The three most common causes of microcytic anemia are iron deficiency, thalassemia trait, and anemia of inflammation. Additional laboratory testing is required for diagnosis. Determination of the rate of development of anemia and examination of a blood smear may provide diagnostic clues to guide more specialized testing. Diagnosis of iron, vitamin B12, or folate deficiency man...



A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development

Fri, 18 Mar 2016 00:00:00 +0100

by Philip J. Byrd, Grant. S. Stewart, Anna Smith, Charlotte Eaton, Alexander J. Taylor, Chloe Guy, Ieva Eringyte, Peggy Fooks, James I. Last, Robert Horsley, Antony W. Oliver, Dragana Janic, Lidija Dokmanovic, Tatjana Stankovic, A. Malcolm R. Taylor Patients with biallelic truncating mutations in PALB2 have a severe form of Fanconi anaemia (FA-N), with a predisposition for developing embryonal-type tumours in infancy. Here we describe two unusual patients from a single family, carrying biallelic PALB2 mutations, one truncating, c.1676_1677delAAinsG;(p.Gln559ArgfsTer2), and the second, c.2586+1G>A; p.Thr839_Lys862del resulting in an in frame skip of exon 6 (24 amino acids). Strikingly, the affected individuals did not exhibit the severe developmental defects typical of FA-N patients and in...



Practical guidance on chronic kidney disease in cats

Fri, 18 Mar 2016 00:00:00 +0100

EXPERT guidance on the diagnosis and treatment of chronic kidney disease (CKD) in cats has been published by the International Society of Feline Medicine (ISFM). The ISFM explains that CKD is a common, complex and progressive disease which is estimated to affect more than one third of cats over 10 years of age. Cats with CKD present with a variety of clinical signs including inappetence, nausea, vomiting, anaemia, hypertension and urinary tract infections and, if the disease is not managed properly, it can severely compromise an animal's quality of life. However, the ISFM points out that the diagnosis of CKD is often not straightforward, with presenting signs varying between individual animals. There can also be problems in interpreting renal function tests. In addition, there is a lack of...

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The impact of ribavirin dosage in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin combination therapy

Fri, 18 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)



Anaemia and cardiac surgery

Fri, 18 Mar 2016 00:00:00 +0100

(Source: Anaesthesia)



The incidence and importance of anaemia in patients undergoing cardiac surgery in the UK – the first Association of Cardiothoracic Anaesthetists national audit

Fri, 18 Mar 2016 00:00:00 +0100

Summary The importance and variability of pre‐operative anaemia in cardiac surgical patients across the UK is not known, and there is debate about its association with patient outcomes. The Association of Cardiothoracic Anaesthetists carried out its first national audit on anaemia and transfusion, and analysed data from 19,033 patients operated on in 12 cardiac surgical centres between 2010 and 2012; 5895 (31%) had pre‐operative anaemia. Centre‐specific prevalence of anaemia varied from 23% to 45%; anaemia was associated with older patients, diabetes and surgical risk (EuroSCORE). Nevertheless, controlling for these factors, regional variation remained an independent effect (p < 0.001). Multivariable analysis demonstrated an independent association of anaemia with transfusion (odd...



Ileal follicular lymphoma with atypical endoscopic findings

Fri, 18 Mar 2016 00:00:00 +0100

Endosc Int Open 2016; 04: E323-E325DOI: 10.1055/s-0042-100721A 72-year-old woman presented with symptomatic anemia without abdominal symptoms. She had no history of abdominal surgery or use of non-steroidal anti-inflammatory drugs. Enhanced computed tomography of the abdomen revealed swelling of multiple intraperitoneal lymph nodes and a high density of mesenteric adipose tissue. Fluorodeoxyglucose (FDG-) positron emission tomography showed high FDG accumulation at the intraperitoneal lymph nodes. Double-balloon enteroscopy detected severe stenosis with an annular ulcer in the lower ileum. She was diagnosed with ileal follicular lymphoma based on histologic examination and fluorescence in situ hybridization analysis of the biopsy specimen. The ileal ulcer was successfully treated by chemot...



Perturbed MafB/GATA1 axis after burn trauma bares the potential mechanism for immune suppression and anemia of critical illness.

Fri, 18 Mar 2016 00:00:00 +0100

Authors: Johnson NB, Posluszny JA, He LK, Szilagyi A, Gamelli RL, Shankar R, Muthumalaiappan K Abstract Patients who survive initial burn injury are susceptible to nosocomial infections. Anemia of critical illness is a compounding factor in burn patients that necessitates repeated transfusions, which further increase their susceptibility to infections and sepsis. Robust host response is dependent on an adequate number and function of monocytes/macrophages and dendritic cells. In addition to impaired RBC production, burn patients are prone to depletion of dendritic cells and an increase in deactivated monocytes. In steady-state hematopoiesis, RBCs, macrophages, and dendritic cells are all generated from a common myeloid progenitor within the bone marrow. We hypothesized in a mouse m...

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Relative Susceptibilities of ABO Blood Groups to Plasmodium falciparum Malaria in Ghana.

Thu, 17 Mar 2016 21:10:02 +0100

Authors: Afoakwah R, Aubyn E, Prah J, Nwaefuna EK, Boampong JN Abstract The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group "A" have been found to be highly susceptible to falciparum malaria whereas blood group "O" is said to confer protection against complicated cases. We analyzed samples from 293 young children less than six years old with malaria in the Korle-Bu Teaching Hospital in Accra, Ghana. It was observed that group O was present in about 16.1% of complicated cases weighed against 40.9% of uncomplicated controls. Individuals with c...



Bhandari S, Kalra PA, Coyne DW. Data confusion. Kidney Int. 2015;88:1445

Thu, 17 Mar 2016 18:07:03 +0100

In the above-mentioned letter, the authors incorrectly referred to the safety period in an IV iron trial as 6 months, while the referred article (Kalra PA, Bhandari S, Saxena S, et al. A randomized trial of iron isomaltoside 1000 versus oral iron in non-dialysis-dependent chronic kidney disease patients with anaemia. Nephrol Dial Transplant. 2015 [e-pub ahead of print; http://dx.doi.org/10.1093/ndt/gfv293]) correctly reports 8 weeks. In that trial there followed a 12-week period in which serious adverse event data were collected, albeit in a nonrobust manner. (Source: Kidney International)



Complex Care Center Forges New Outpatient Model

Thu, 17 Mar 2016 17:07:32 +0100

UR Medicine's Complex Care Center is Rochester’s first primary care practice dedicated to caring for adults with chronic childhood-onset conditions such as cystic fibrosis, sickle cell anemia, childhood cancers, autism, and intellectual and developmental disabilities. (Source: University of Rochester Medical Center Press Releases)



Horse anti‐thymocyte globulin (hATG) and eculizumab as concomitant therapeutic approach in an aplastic PNH patient: go or no‐go?!

Thu, 17 Mar 2016 08:34:21 +0100

This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)



Micronutrient Supplementation after Biliopancreatic Diversion with Duodenal Switch in the Long Term

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions The results of our study show that the prevalence of vitamin and mineral deficiencies after BPD-DS is 81.4 % at a minimum follow-up of 5 years. The initial prescription of micronutrient supplementation and further adjustments during the first follow-up were insufficient to avoid long-term micronutrient deficiencies. Life-long monitoring of micronutrients at a specialized bariatric center and possibly a better micronutrient supplementation, is crucial to avoid a deficient micronutrient status at every stage after malabsorptive bariatric surgery. (Source: Obesity Surgery)

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A Time Interval of More Than 18 Months Between a Pregnancy and a Roux-en-Y Gastric Bypass Increases the Risk of Iron Deficiency and Anaemia in Pregnancy

Thu, 17 Mar 2016 00:00:00 +0100

Conclusion A long surgery-to-pregnancy time interval after a RYGB increases the risk of iron deficiency anaemia but not of other nutritional deficits. Time interval does not seem to have an adverse effect on the obstetrical outcome, including intrauterine growth restriction. Specific attention is needed on iron deficit with increasing surgery-to-pregnancy time interval. (Source: Obesity Surgery)



Fermentation of food and feed: A technology for efficient utilization of macro and trace elements in monogastrics

Thu, 17 Mar 2016 00:00:00 +0100

Publication date: Available online 15 March 2016 Source:Journal of Trace Elements in Medicine and Biology Author(s): Elke Humer, Karl Schedle Mineral deficiencies, especially of iron, zinc, and calcium, respectively, negatively affect human health and may lead to conditions such as iron deficiency anemia, rickets, osteoporosis, and diseases of the immune system. Cereal grains and legumes are of global importance in nutrition of monogastrics (humans and the respective domestic animals) and provide high amounts of several minerals, e.g. iron, zinc, and calcium. Nevertheless, their bioavailability is low. Plants contain phytates, the salts of phytic acid, chemically known as inositol-hexakisphosphate, which interact with several minerals and proteins. However, phytate may be hydrolysed by...



Protective oral vaccination against infectious Salmon Anaemia virus in Salmo Salar

Thu, 17 Mar 2016 00:00:00 +0100

This study provides new insights into fish protection and immune response induced by an oral vaccine against ISA, but also promises future development of preventive solutions or validation of the current existing therapies. (Source: Fish and Shellfish Immunology)



A comparison of toxicity profiles between the lower and standard dose capecitabine in breast cancer: a systematic review and meta-analysis

Thu, 17 Mar 2016 00:00:00 +0100

Abstract Capecitabine 1000 mg/m2 bid × 14 days every 21 days (14/21) has been reported to have similar efficacy but more favorable toxicity profile than the approved dosage of 1250 mg/m2. However, a dose-toxicity relationship of capecitabine in breast cancer patients has not been fully elucidated. We performed a systematic review and meta-analysis to compare a safety profile between capecitabine starting dose of 1000 and 1250 mg/m2 bid. Studies were identified using PubMed, ASCO, and San Antonio Breast Cancer Symposium abstract databases through December 2015. Eligible trials included phase II/III trials of capecitabine monotherapy at 1000 or 1250 mg/m2 bid (14/21) for breast cancer patients that reported adequate safety data for all (grade 1–4) or high (grade 3–4) gr...



Intravenous iron sucrose reverses anemia-induced cardiac remodeling, prevents myocardial fibrosis, and improves cardiac function by attenuating oxidative/nitrosative stress and inflammation

Thu, 17 Mar 2016 00:00:00 +0100

According to recent clinical trial data, correction of iron deficiency with intravenous (i.v.) iron has favorable outcomes on cardiac function. We evaluated whether i.v. iron treatment of anemic rats has favorable effect on the left ventricular (LV) performance and remodeling and the role of oxidative/nitrosative stress and inflammation in the process. (Source: International Journal of Cardiology)

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Early percutaneous closure of iatrogenic cardiac defects following multiple valvular surgery with direct guidewire support is a potentially curative technique with demonstrable clinical improvements

Thu, 17 Mar 2016 00:00:00 +0100

Iatrogenic cardiac defects are rare complications of valvular surgery. Reoperation is associated with increased risk of recurrent defects, morbidity and mortality [1]. Percutaneous closure with closure devices has evolved to be a clinically feasible solution and replaces the need for reoperation [2–5]. These iatrogenic defects include paravalvular leaks (PVL), ventricular septal defects and rarely, left ventricular to right atrial (Gerbode) defect. Patients develop congestive cardiac failure (CCF), haemolytic anemia and hemodynamic instability, and are often subjected to ineffective medical therapy prior to percutaneous closure. (Source: International Journal of Cardiology)



The effect of methanolic extract of Buchanania lanzan Spreng seeds on hematological indices

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions: The improvement of PCV, Hb, and RBC values is an indication of the anti-anemic effect which may be due to the stimulation of RBC production in bone marrow. Further, stimulated production of WBC could be as a result of possible stimulus of the immune system. Hence, this study confirms that the extract of B. lanzan could be useful for the treatment of anemia. (Source: Indian Journal of Pharmacology)



TRMA syndrome (thiamine-responsive megaloblastic anaemia): An example of rare monogenic diabetes: is thiamine a magic pill for anaemia and diabetes?

Thu, 17 Mar 2016 00:00:00 +0100

We report a 16-month-old male, a youngest case of genetically confirmed TRMA syndrome in Indian phenotype, born to consanguineous parents. We found a homozygous pathogenic variant in exon 2 of the SLC19A2 gene, c.314G>A (p.Gly105Glu). The anaemia showed a good response to daily thiamine doses and was able to avoid unwanted blood transfusion. There was no benefit with regard to insulin requirement. Early detection of hearing impairment and referral to audiological treatment was possible. The report indicates that TRMA should be considered as a differential diagnosis for patients presenting with suggestive clinical symptoms which would have tremendous impact on patient management if identified early. (Source: International Journal of Diabetes in Developing Countries)






Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents

Thu, 17 Mar 2016 00:00:00 +0100

This study identifies GATA2 mutations as the most common germline defect predisposing to pediatric MDS with a very high prevalence in adolescents with monosomy 7. GATA2 mutations do not confer poor prognosis in childhood MDS. However, the high risk for progression to advanced disease must guide decision-making toward timely HSCT. (Source: Blood)

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Pomalidomide reverses {gamma}-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitors

Thu, 17 Mar 2016 00:00:00 +0100

Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was proposed to induce fetal hemoglobin production by an unknown mechanism. Here, we report that pomalidomide induced a fetal-like erythroid differentiation program, leading to a reversion of -globin silencing in adult human erythroblasts. Pomalidomide acted early by transiently delaying erythropoiesis at the burst-forming unit-erythroid/colony-forming unit-erythroid transition, but without affecting terminal differentiation. Further, the transcription networks involved in -globin repression were selectively and differentially affected by pomalidomide including BCL11A, SOX6, IKZF1, KLF1, and LSD1. IKAROS (IKZF1), a known target of pomalid...



A case of multiple myeloma presenting as a distal renal tubular acidosis with extensive bilateral nephrolithiasis

Thu, 17 Mar 2016 00:00:00 +0100

Conclusion Isolated distal renal tubular acidosis is a rare presentation of multiple myeloma. In the absence of hypercalciuria and demonstrable light chain excretion in urine, we assumed that the distal renal tubular acidosis could have been caused by monoclonal hypergammaglobulinaemic state of multiple myeloma. (Source: BMC Hematology)



An assessment of methods used in the investigation of iron status: findings in a population of young British South Asian children

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions Among 205 British South Asian children aged 4–43 months with high incidences of anaemia, iron deficiency, infection and α-thalassaemia, 151 (73.6%) were classified using haemoglobin, MCH, ferritin and CRP values. In 42 non-anaemic, iron-sufficient children with subnormal MCH values, that is with a phenotype of α-thalassaemia trait, RDW, %hypo and ZPP values did not differ significantly from those with iron-deficient erythropoiesis. Raised RDW, %hypo and ZPP values should be interpreted with caution in non-anaemic young British South Asian children with microcytosis. (Source: Journal of Clinical Pathology)



Nocturnal haemoglobin oxygen desaturation in urban and rural East African paediatric cohorts with and without sickle cell anaemia: a cross-sectional study

Thu, 17 Mar 2016 00:00:00 +0100

Low haemoglobin oxygen saturation (SpO2) predicts complications in children with sickle cell anaemia (SCA) in the North but there are few data from Africa, where the majority of the patients reside. We measured daytime and overnight SpO2 in children with SCA in routine follow-up clinic, and controls without symptoms of SCA, comparing rural (Kilifi, Kenya) and urban (Dar-es-Salaam, Tanzania) cohorts. Daytime SpO2 was lower in 65 Tanzanian children with SCA (TS; median 97 (IQR 94–100)%); p<0.0001) than in 113 Kenyan children with SCA (KS; 99 (98–100)%) and 20 Tanzanian controls (TC; 100 (98–100)%). Compared with 95 Kenyan children with SCA, in 54 Tanzanian children with SCA and 19 TC who returned for overnight oximetry, mean (KS 99.0 (96.7–99.8)%; TS 97.9 (95.4&nda...



Anemia and frailty

Wed, 16 Mar 2016 21:44:53 +0100

Röhrig G (Source: Clinical Interventions in Aging)

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Distinct Metabolic Signature of Human Bladder Cancer Cells Carrying an Impaired Fanconi Anemia Tumor-Suppressor Signaling Pathway

Wed, 16 Mar 2016 15:46:45 +0100

Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.6b00076 (Source: Journal of Proteome Research)



What is babesiosis and what can be done to stop its spread?

Wed, 16 Mar 2016 13:45:48 +0100

An outbreak of the disease affecting some dogs in Essex has vets, pet owners and the government very concernedWhat is babesiosis?A malaria-like disease resulting in anaemia in dogs which is caused by single-celled babesia parasites spread by ticks. Continue reading... (Source: Guardian Unlimited Science)



Reduced 25-OH vitamin D in patients with autoimmune cytopenias, clinical correlations and literature review

Wed, 16 Mar 2016 00:00:00 +0100

In conclusion, vitamin D is reduced in autoimmune cytopenias and correlate with disease severity, supporting its possible protective role against the development of autoimmunity. Literature review showed vitamin D deficiency reports both in onco- and in non onco-hematologic diseases with a relationship with disease severity/activity in myeloid and lymphoid neoplasms, as well as in sickle cell disease. Supplementation has produced weak results in autoimmune and hematologic diseases, and further studies are needed. (Source: Autoimmunity Reviews)



Pregnancy-Associated Atypical Hemolytic-Uremic Syndrome

Wed, 16 Mar 2016 00:00:00 +0100

Conclusion Diagnosis of p-aHUS is challenging, as it can mimic various diseases found during pregnancy and the postpartum. Plasma exchange should be promptly initiated within 24 hours of diagnosis. Eculizumab has risen to become an important tool to improve long-term comorbidities and mortality in this group population.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)



Infant Parenteral Nutrition Remains a Significant Source for Aluminum Toxicity.

Wed, 16 Mar 2016 00:00:00 +0100

CONCLUSIONS: Aluminum contamination in infant PN remains almost 3 times higher than the advised maximum exposure (<5 mcg/kg/d, Food and Drug Administration 2004). Unexpectedly, an association between infant weight and aluminum exposure was not apparent, likely due to the homogeneity of our population. Isolating the source of aluminum contamination is difficult, as multiple components appear to be involved. Calcium gluconate is likely still a major contributor, but further investigations into individual components are warranted to promote the reduction of aluminum in infant PN. PMID: 26983685 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)

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[Small bowel obstruction secondary to massive hookworm infestation complicated by fatal plurimicrobial bacteriemia].

Tue, 15 Mar 2016 15:50:04 +0100

CONCLUSION: We report a case of acute surgical abdominal presentation with septicemia and refractory shock syndrome due to ileal translocation secondary to massive hookworm infestation. To the best of our knowledge, such a case has not yet been reported. PMID: 26971967 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)



[Anaemia in pregnancy and in the immediate postpartum period. Prevalence and risk factors in pregnancy and childbirth].

Tue, 15 Mar 2016 12:14:01 +0100

CONCLUSIONS: Anaemia in the immediate postpartum is a prevalent problem. The factors most associated postpartum anaemia were antepartum anaemia and instrumental delivery. If patients arrive at the day of delivery with haemoglobins≥12,6g/dl and were restricted to necessary instrumented deliveries and cesarean sections, episiotomies and we could avoid perineal tears we can decrease anaemia in the immediate postpartum period very significantly. PMID: 26971977 [PubMed - as supplied by publisher] (Source: Medicina Clinica)



Overview of the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) Project

Tue, 15 Mar 2016 00:00:00 +0100

This article provides an overview of the BRINDA project and describes key research questions and programmatic and research implications. Findings from this project will inform global guidelines on the assessment of anemia and micronutrient status and will guide the development of a research agenda for future longitudinal studies. (Source: Advances in Nutrition)



Safety concerns about intravenous iron therapy in patients with chronic kidney disease

Tue, 15 Mar 2016 00:00:00 +0100

Anaemia in chronic kidney disease (CKD) is managed primarily with erythropoiesis-stimulating agents (ESAs) and iron therapy. Following concerns around ESA therapy, intravenous (IV) iron is being administered more and more worldwide. However, it is still unclear whether this approach is safe at very high doses or in the presence of very high ferritin levels. Some observational studies have shown a relationship between either high ferritin level or high iron dose and increased risk of death, cardiovascular events, hospitalization or infection. Others have not been able to confirm these findings. However, they suffer from indication biases. On the other hand, the majority of randomized clinical trials have only a very short follow-up (and thus drug exposure) and are inadequate to assess the m...



Karyomegalic interstitial nephritis and DNA damage-induced polyploidy in Fan1 nuclease-defective knock-in mice [Research Communications]

Tue, 15 Mar 2016 00:00:00 +0100

The Fan1 endonuclease is required for repair of DNA interstrand cross-links (ICLs). Mutations in human Fan1 cause karyomegalic interstitial nephritis (KIN), but it is unclear whether defective ICL repair is responsible or whether Fan1 nuclease activity is relevant. We show that Fan1 nuclease-defective (Fan1nd/nd) mice develop a mild form of KIN. The karyomegalic nuclei from Fan1nd/nd kidneys are polyploid, and fibroblasts from Fan1nd/nd mice become polyploid upon ICL induction, suggesting that defective ICL repair causes karyomegaly. Thus, Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy, a role that we show is not shared by the Fanconi anemia pathway or the Slx4–Slx1 nuclease also involved in ICL repair. (Source: Genes and Development)

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Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction [Research Papers]

Tue, 15 Mar 2016 00:00:00 +0100

Deficiency of FANCD2/FANCI-associated nuclease 1 (FAN1) in humans leads to karyomegalic interstitial nephritis (KIN), a rare hereditary kidney disease characterized by chronic renal fibrosis, tubular degeneration, and characteristic polyploid nuclei in multiple tissues. The mechanism of how FAN1 protects cells is largely unknown but is thought to involve FAN1's function in DNA interstrand cross-link (ICL) repair. Here, we describe a Fan1-deficient mouse and show that FAN1 is required for cellular and organismal resistance to ICLs. We show that the ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance. Epistasis analyses reveal that FAN1 has cros...



Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance [Research Papers]

Tue, 15 Mar 2016 00:00:00 +0100

Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such as D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1 mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize at DNA damage-induced ...



Intracranial aneurysms in sickle cell anemia: clinical and imaging findings

Tue, 15 Mar 2016 00:00:00 +0100

Conclusions Adult patients with sickle cell disease have a high prevalence of aneurysm formation. Both pediatric and adult patients with sickle cell disease tend to develop multiple aneurysms with frequent involvement of atypical locations, in both anterior and posterior circulations. (Source: Journal of NeuroInterventional Surgery)



Lattice Boltzmann Simulation of Healthy and Defective Red Blood Cell Settling in Blood Plasma

Tue, 15 Mar 2016 00:00:00 +0100

In this paper, an attempt has been made to study sedimentation of a red blood cell (RBC) in a plasma-filled tube numerically. Such behaviors are studied for a healthy and a defective cell which might be created due to human diseases, such as diabetes, sickle-cell anemia, and hereditary spherocytosis. Flow-induced deformation of RBC is obtained using finite-element method (FEM), while flow and fluid–membrane interaction are handled using lattice Boltzmann (LB) and immersed boundary methods (IBMs), respectively. The effects of RBC properties as well as its geometry and orientation on its sedimentation rate are investigated and discussed. The results show that decreasing frontal area of an RBC and/or increasing tube diameter results in a faster settling. Comparison of healthy and diabetic c...



Letter to the Editor on “Rate of Transfusions Following Total Knee Arthroplasty in Patients Receiving Lovenox or High Dose Aspirin”

Tue, 15 Mar 2016 00:00:00 +0100

We had the opportunity to read the article by Miller and colleagues addressing the rate of transfusion in patients receiving two different regimes of thromboprophylaxis after knee replacement surgery [1]. We acknowledge the authors endeavor to conduct such an interesting retrospective analysis. They report a remarkable statistically significant difference in both hemoglobin and hematocrit drops and the rate of transfusion between groups. We consider that these findings are also clinically significant as postoperative anemia remains one of the most common complications after major orthopedic surgery [2]. (Source: The Journal of Arthroplasty)

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Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy, with anti-IL-6 receptor antibody and steroids.

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Fujiwara S, Mochinaga H, Nakata H, Ohshima K, Matsumoto M, Uchiba M, Mikami Y, Hata H, Okuno Y, Mitsuya H, Nosaka K Abstract TAFRO syndrome is a rare variant type of multicentric Castleman disease, which is characterized by thrombocytopenia, anasarca, reticulin fibrosis of bone marrow, renal dysfunction and organomegaly. Here, we report a case of TAFRO syndrome that was successfully treated with tocilizumab. A 50-year-old man, who presented with fever, epigastric pain, abdominal fullness, and massive edema of the extremities, was admitted to our hospital. Computed tomography revealed bilateral pleural effusions, ascites, and lymphadenopathy. Laboratory data showed renal dysfunction, anemia, and thrombocytopenia. Examination of bone marrow and cervical lymph nodes led to a ...



Efficacy and safety of sofosbuvir/ledipasvir for the treatment of patients with hepatitis C virus re‐infection after liver transplantation

Mon, 14 Mar 2016 00:00:00 +0100

ConclusionAntiviral treatment with SOF/LDV is highly effective, safe, and well tolerated in OLT recipients. The addition of RBV often results in severe anemia, requiring dose reduction or discontinuation.This article is protected by copyright. All rights reserved. (Source: Transplant Infectious Disease)



PIEZO1 gene mutation in a Japanese family with hereditary high phosphatidylcholine hemolytic anemia and hemochromatosis-induced diabetes mellitus.

Mon, 14 Mar 2016 00:00:00 +0100

We report here the discovery of a PIEZO1 gene mutation in a Japanese family (father, daughter, and son) who were previously diagnosed with hereditary high phosphatidylcholine hemolytic anemia (HPCHA). All of the affected family members had non-spherocytic hemolytic anemia associated with severe hemochromatosis-related diabetes mellitus. Although the causative correlation between HPCHA and PIEZO1-gene mutated HX/DHS remains to be clarified, our findings raise an important question as to whether any of the HPCHA cases previously diagnosed in Japan may have in fact been the form of hemolytic anemia known as HX/DHS with PIEZO1 gene mutation. PMID: 26971963 [PubMed - as supplied by publisher] (Source: International Journal of Hematology)



Carfilzomib Triple Combination Therapy: A Review in Relapsed Multiple Myeloma

Mon, 14 Mar 2016 00:00:00 +0100

Abstract Carfilzomib (Kyprolis®) is a proteasome inhibitor that binds selectively and irreversibly to the 20S proteasome (the proteolytic core particle within the 26S proteasome), inducing growth arrest and apoptosis. This intravenous drug is approved in the EU and the USA as combination therapy with oral lenalidomide and intravenous or oral dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy. In the multinational, phase III ASPIRE study in this patient population, carfilzomib triple combination therapy significantly prolonged progression-free survival (PFS), reflecting a clinically relevant gain in PFS of 8.7 months, compared with lenalidomide plus dexamethasone. Improvements in overall response rate and patients’ glo...



Diamond–Blackfan anemia: death by heme toxicity?

Mon, 14 Mar 2016 00:00:00 +0100

(Source: European Journal of Haematology)

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Synchronous rectal adenocarcinoma and splenic marginal zone lymphoma.

Sun, 13 Mar 2016 18:01:02 +0100

Authors: Srikumar T, Markow M, Centeno B, Hoffe S, Tao J, Fernandez H, Strosberg J, Shibata D Abstract Synchronous cancers of different primary origin are rare. Here, we describe the case of a patient with concomitant diagnoses of rectal adenocarcinoma and splenic marginal zone lymphoma (smzl). A 57-year-old woman initially presented with abdominal pain. Physical examination and computed tomography demonstrated massive splenomegaly, and a complete blood count revealed microcytic anemia and lymphopenia. During the subsequent evaluation, she presented with hematochezia, melena, and constipation, which prompted gastroenterology referral. Subsequent endoscopic rectal ultrasonography revealed a T3N1 moderately differentiated rectal adenocarcinoma, with computed tomography imaging of che...



Hepcidin and ferroportin expression in breast cancer tissue and serum and their relationship with anemia.

Sun, 13 Mar 2016 18:01:02 +0100

CONCLUSIONS: In bca patients, expression of hepcidin in serum was high, but expression of fpn was low, suggesting that serum hepcidin plays a major role in anemia in those patients. Expression of hepcidin and fpn in bca tissue showed no correlation with their expression in serum and no clear relationship with anemia. PMID: 26966409 [PubMed] (Source: Current Oncology)



The cost-utility of treating anemia with continuous erythropoietin receptor activator or Epoetin versus routine blood transfusions among chronic hemodialysis patients.

Sun, 13 Mar 2016 13:16:02 +0100

CONCLUSION: Our study suggests that managing anemia in dialysis patients with CERA or EpoB may result in better outcomes with higher overall costs. Considering different assumptions, we found substantial variability in the estimates of the cost-utility and incremental of using CERA or EpoB. PMID: 26966386 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)






Antianemic Treatment of Cancer Patients in German Routine Practice: Data from a Prospective Cohort Study-The Tumor Anemia Registry.

Sun, 13 Mar 2016 02:02:05 +0100

Authors: Steinmetz T, Schröder J, Plath M, Link H, Vogt M, Frank M, Marschner N Abstract The aim of this prospective cohort study was to assess current antianemic treatment of cancer patients in German routine practice, including diagnostics, treatments, and quality of life (QoL). 88 study sites recruited 1018 patients at the start of antianemic treatment with hemoglobin (Hb) levels <11 g/dL (females) or <12 g/dL (males). Patients were followed up for 12 weeks. 63% of the patients had inoperable solid tumors, 22% operable solid tumors, and 15% hematological malignancies. Over 85% received chemotherapy. Median age was 67 years; 48% were male. Red blood cell transfusions (RBCTx) were given to 59% of all patients and to 55% of the patients with Hb ≥8 g/dL on day 1 of th...

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Altered E-NTPDase/E-ADA activities and CD39 expression in platelets of sickle cell anemia patients

Sun, 13 Mar 2016 00:00:00 +0100

This study aimed to investigate the activities of purinergic system ecto-enzymes present on the platelet surface as well as CD39 and CD73 expressions on platelets of SCA treated patients. Fifteen SCA treated patients and 30 health subjects (control group) were selected. Ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase), ecto-5′-nucleotidase (E-5′-NT) and ecto-adenosine deaminase (E-ADA) activities were measured in platelets isolated from these individuals. Results demonstrated an increase of 41 % in the E-NTPDase for ATP hydrolysis, 52% for ADP hydrolysis and 60 % in the E-ADA activity in SCA patients (P <0.05); however, a two folds decrease in the CD39 expression in platelets was observed in the same group (P <0.01). The increased E-NTPDase activity could be a ...



Unexplained Anemia in a Young Infant Due to Congenital Malaria

Sat, 12 Mar 2016 19:07:26 +0100

No abstract available (Source: The Pediatric Infectious Disease Journal)



Can Serum Gdf-15 be Associated with Functional Iron Deficiency in Hemodialysis Patients?

Sat, 12 Mar 2016 18:35:07 +0100

Abstract Functional iron deficiency (FID) incidence is gradually increasing in hemodialysis (HD) patients. Recently, high levels of GDF-15 supressed the iron regulatory protein hepcidin and GDF-15 expression increased in iron-deficient patients. The relationship between FID, GDF-15, and hepcidin is currently unknown. The present study aimed to evaluate the association between GDF-15, hepcidin, and FID in chronic HD patients. Serum GDF-15 and hepcidin concentrations were measured in 105 HD patients and 40 controls. FID is defined as serum ferritin >800 ng/mL, TSAT <25 %, Hb levels <11 g/dL, and reticulocyte haemoglobin content (CHr) <29 pg. Serum GDF-15 and hepcidin levels were increased significantly in HD patients with FID, compared to HD patients without anemia ...



Re-evaluation of Need for Bone Marrow Examination in Patients with Isolated Thrombocytopenia Contributors

Sat, 12 Mar 2016 18:35:07 +0100

Abstract Diagnosis of immune thrombocytopenia (ITP) is based on clinical suspicion and normal peripheral smear except for thrombocytopenia. Bone marrow examination is carried out to rule out leukemia, myelodysplastic syndrome or aplastic anemia. However, in most cases, clinical diagnosis is not altered after the bone marrow reports. Hence, this present study was carried out to evaluate the justification for bone marrow examination in the setting of isolated thrombocytopenia. All patients presenting to the hematology OPD with isolated thrombocytopenia and suspected diagnosis of ITP, between October 2011 and April 2013, were included in the study. Data was collected from bone marrow reports and outpatient records. A total of 353 cases were found. 319 cases had features of typical I...



The Pattern of Juvenile Idiopathic Arthritis in a Single Tertiary Center in Saudi Arabia.

Sat, 12 Mar 2016 11:17:02 +0100

Conclusion. SoJIA is the most common JIA subtype in our study. A population based rather than a single center study will give more details about JIA characteristics in Saudi Arabia. PMID: 26966610 [PubMed] (Source: International Journal of Inflammation)

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Role of Genetic Factors in the Pathogenesis of Radial Deficiencies in Humans.

Sat, 12 Mar 2016 01:07:02 +0100

Authors: Elmakky A, Stanghellini I, Landi A, Percesepe A Abstract Radial deficiencies (RDs), defined as under/abnormal development or absence of any of the structures of the forearm, radial carpal bones and thumb, occur with a live birth incidence ranging from 1 out of 30,000 to 1 out 6,000 newborns and represent about one third/one fourth of all the congenital upper limb anomalies. About half of radial disorders have a mendelian cause and pattern of inheritance, whereas the remaining half appears sporadic with no known gene involved. In sporadic forms certain anomalies, such as thumb or radial hypoplasia, may occur either alone or in association with systemic conditions, like vertebral abnormalities or renal defects. All the cases with a mendelian inheritance are syndromic forms, ...



Drug Disposition Issues in CKD: Implications for Drug Discovery and Regulatory Approval

Sat, 12 Mar 2016 00:00:00 +0100

Publication date: March 2016 Source:Advances in Chronic Kidney Disease, Volume 23, Issue 2 Author(s): Alvin Tieu, Andrew A. House, Bradley L. Urquhart Patients with chronic kidney disease (CKD) have several comorbidities that require pharmacologic intervention including hypertension, diabetes, anemia, and cardiovascular disease. Advanced CKD patients (eg, treated with hemodialysis) take an average of 12 medications concurrently and are known to suffer from an increased number of medication-related adverse drug events. Recent basic and clinical research has identified altered renal and nonrenal drug clearance in CKD as one mediator of the increased adverse drug events observed in this patient population. This review will briefly describe pharmacokinetic considerations in CKD, review th...



The challenge of an aged and shrinking population: Lessons to be drawn from Japan’s experience

Sat, 12 Mar 2016 00:00:00 +0100

Publication date: Available online 3 March 2016 Source:The Journal of the Economics of Ageing Author(s): Peter S. Heller Japan is the first industrial country to have an aged and shrinking population. Such a demographic situation poses numerous macroeconomic and microeconomic challenges, with the former further amplified by Japan’s high public debt level. This paper underscores the multiple criteria to consider in evaluating Japan’s policies as it has approached this demographic tipping point. In examining Japan’s macroeconomic policies as well as the specifics of its social insurance policy framework, it seeks to draw lessons relevant for countries confronting the prospect of an aged population, while recognizing the importance of viewing Japan’s policies in the context of its ...



Serologically silent, occult equine infectious anemia virus (EIAV) infections in horses.

Sat, 12 Mar 2016 00:00:00 +0100

Publication date: Available online 11 March 2016 Source:Veterinary Microbiology Author(s): Sonia Ricotti, Maria Inés Garcia, Carolina Veaute, Alejandra Bailat, Eduardo Lucca, R. Frank Cook, Sheila J. Cook, Adriana Soutullo Molecular and serological techniques for Equine Infectious Anemia Virus (EIAV) diagnosis were compared using samples from 59 clinically normal horses stabled on five farms in the Santa Fe Province of Argentina. Of these 26 (44.1%) were positive in official AGID tests and/or gp45/gp90-based ELISA. Surprisingly 18 of the 33 seronegative horses were positive in a PCR against viral sequences encoding gp45 (PCR-positive/AGID-negative) with all but one remaining EIAV-antibody negative throughout a two year observation period. The gp45 PCR results are supported by fa...



Boceprevir plus peginterferon/ribavirin for treatment of chronic hepatitis C in Russia.

Fri, 11 Mar 2016 13:09:02 +0100

CONCLUSION: Regulatory approval has been obtained for boceprevir plus PR in Russian patients with HCV genotype 1 infection based on the results of this study. PMID: 26962399 [PubMed] (Source: World Journal of Hepatology)

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