Last Build Date: Mon, 28 Mar 2016 16:23:41 +0100
Mon, 28 Mar 2016 14:22:08 +0100Conclusions & InferencesIn the work‐up of NCCP, ambulatory 24‐h manometry has a low additional diagnostic yield. However, it remains the best technique to identify esophageal spasm as the cause of symptoms. This is particularly useful when an unequivocal diagnosis is needed before treatment. Comparing the diagnostic yield of high‐resolution manometry and 24‐h ambulatory pressure monitoring in patients with non‐cardiac chest pain, we found that when the Chicago classification v3.0 was applied, HRM did not identify any of the four (6.8%) patients with esophageal spasm on 24‐h measurement. However, taking into account other more subtle abnormalities, such as simultaneous (rapid) or repetitive contractions, HRM had a sensitivity of 75% and a specificity of 98.2% for the diagno...
Mon, 28 Mar 2016 14:07:15 +0100ConclusionsVLDM is non‐inferior and statistically superior to HDM in glycemic control in Chinese T2DM patients inadequately controlled with low‐dose metformin.http://ClinicalTrials.gov: NCT01541956.Novartis Pharmaceuticals (China). (Source: Diabetes, Obesity and Metabolism)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Shabana F Pasha & Jonathan A Leighton (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Breath Testing for Small Intestinal Bacterial Overgrowth: A Means to Enrich Rifaximin Responders in IBS Patients? American Journal of Gastroenterology 111, 305 (March 2016). doi:10.1038/ajg.2016.32 Authors: Amit Gupta & William D Chey (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Breath Testing for Small Intestinal Bacterial Overgrowth: Should We Bother? American Journal of Gastroenterology 111, 307 (March 2016). doi:10.1038/ajg.2016.30 Author: Mark Pimentel (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100American Journal of Gastroenterology 111, 309 (March 2016). doi:10.1038/ajg.2015.265 Author: K Vinayachandran Nair (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Yousef Usta, Cristina Ramirez & Brenda Dennert (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: A Martinez-Turnes, P Estevez-Boullosa & J I Rodriguez Prada (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Alhareth Al Juboori, Satinder Kaur & Atigadda N Reddy (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Omer Ozturk, Yusuf Bayraktar & Aytekin Akyol (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Raghav Bansal, Ishita Rajnish, Loveleen Sidhu, Emeka Anyadike & Ahmed Al-khazraji (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Yu-Bin Zhou, Yong Yuan, Bing Hu & Guo-Wei Che (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Kao-Lang Liu, I-Lun Shih, Yun-Cheng Huang & Chien-Hung Chen (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Chin-Chen Chang, Chiun Hsu & Kao-Lang Liu (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100American Journal of Gastroenterology 111, 314 (March 2016). doi:10.1038/ajg.2016.35 (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Stephen A McClave, John K DiBaise, Gerard E Mullin & Robert G Martindale (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100American Journal of Gastroenterology 111, 335 (March 2016). doi:10.1038/ajg.2016.36 Author: Ganesh R Veerappan (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100American Journal of Gastroenterology 111, 336 (March 2016). doi:10.1038/ajg.2016.33 (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Charles J Kahi, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas J Robertson & Douglas K Rex (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100American Journal of Gastroenterology 111, 347 (March 2016). doi:10.1038/ajg.2016.34 Author: Steven L Carpenter (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: James M Richter, Peter B Kelsey & Emily J Campbell (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Kayla A Feld & Andrew D Feld (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Jun Pan, Lei Xin, Yi-Fei Ma, Liang-Hao Hu & Zhao-Shen Li (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100American Journal of Gastroenterology 111, 366 (March 2016). doi:10.1038/ajg.2016.12 Author: William D Chey (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Sabine Roman, Laure Huot, Frank Zerbib, Stanislas Bruley des Varannes, Guillaume Gourcerol, Benoit Coffin, Alain Ropert, Adeline Roux & François Mion (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Jyh-Ming Liou, Ming-Jong Bair, Chieh-Chang Chen, Yi-Chia Lee, Mei-Jyh Chen, Chien-Chuan Chen, Cheng-Hao Tseng, Yu-Jen Fang, Ji-Yuh Lee, Tsung-Hua Yang, Jiing-Chyuan Luo, Jeng-Yih Wu, Wen-Hsiung Chang, Chun-Chao Chang, Chi-Yi Chen, Po-Yueh Chen, Chia-Tung Shun, Wen-Feng Hsu, Hsu-Wei Hung, Jaw-Town Lin, Chi-Yang Chang & Ming-Shiang Wu (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Sheila Barnett, Adelina Hung, Roy Tsao, Julie Sheehan, Bolanle Bukoye, Sunil G Sheth & Daniel A Leffler (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Paresh P Mehta, Gursimran Kochhar, Mazen Albeldawi, Brian Kirsh, Maged Rizk, Brian Putka, Binu John, Yinghong Wang, Nicole Breslaw, Rocio Lopez & John J Vargo (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Sumant Inamdar, Divyesh V Sejpal, Mohammed Ullah & Arvind J Trindade (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Impact of Smoking Cessation on the Clinical Course of Crohn’s Disease Under Current Therapeutic Algorithms: A Multicenter Prospective Study American Journal of Gastroenterology 111, 411 (March 2016). doi:10.1038/ajg.2015.401 Authors: Tiago Nunes, Maria Josefina Etchevers, Valle García-Sánchez, Daniel Ginard, Eva Martí, Manuel Barreiro-de Acosta, Fernando Gomollón, Maite Arroyo, Guillermo Bastida, Benito Gonzalez, David Monfort, Esther García-Planella, Carolina Figueroa, Julián Panés & Miquel Sans (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Editorial: Smoking Cessation for Crohn’s Disease: Clearing the Haze American Journal of Gastroenterology 111, 420 (March 2016). doi:10.1038/ajg.2016.45 Author: Gilaad G Kaplan (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Ian M Johnston, Jonathan D Nolan, Sanjeev S Pattni, Richard N Appleby, Justine H Zhang, Sarah L Kennie, Gaganjit K Madhan, Sina Jameie-Oskooei, Shivani Pathmasrirengam, Jeremy Lin, Albert Hong, Peter H Dixon, Catherine Williamson & Julian R F Walters (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100American Journal of Gastroenterology 111, 433 (March 2016). doi:10.1038/ajg.2016.23 Author: Michael Camilleri (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Livia Archibugi, Gabriele Capurso & Gianfranco Delle Fave (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100De novo Malignancy and Recurrent Alcoholic Cirrhosis Account for 70% of Deaths in Patients Transplanted for End-Stage Alcoholic Liver Disease American Journal of Gastroenterology 111, 436 (March 2016). doi:10.1038/ajg.2016.10 Authors: Jef Verbeek, David Cassiman & Frederik Nevens (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Severe Eosinophilic Gastroenteritis in a Crohn’s Disease Patient Treated With Infliximab and Adalimumab American Journal of Gastroenterology 111, 437 (March 2016). doi:10.1038/ajg.2015.438 Authors: Amanda Muir, Lea Surrey, Alyssa Kriegermeier, Ala Shaikhkalil & David A Piccoli (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Sylvie Pillet, Nicolas Williet, Anne Pouvaret, Emilie Del Tedesco, Pierre Saint-Sardos, Bruno Pozzetto & Xavier Roblin (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Andreas Stallmach, Kathleen Lange, Juergen Buening, Christian Sina, Marius Vital & Dietmar H Pieper (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Joan Kheder, Samuel Han & Wahid Y Wassef (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100CALENDAR OF COURSES, SYMPOSIUMS, AND CONFERENCES American Journal of Gastroenterology 111, 445 (March 2016). doi:10.1038/ajg.2016.46 (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 22:00:00 +0100Authors: Elliot B Tapper, Neil Sengupta, M G Myriam Hunink, Nezam H Afdhal & Michelle Lai (Source: The American Journal of Gastroenterology)
Sun, 27 Mar 2016 21:38:02 +0100This article reviews the palliative management of unresectable pancreatic cancer, including potential palliative resection, surgical and endoscopic biliary and gastric decompression, and pain control with celiac plexus block. PMID: 27013367 [PubMed - in process] (Source: The Surgical Clinics of North America)
Sun, 27 Mar 2016 17:11:02 +0100CONCLUSIONS Verapamil overdose is has a comparatively high mortality rate and there is no effective antidote. Treatment generally involves gastric decontamination and symptomatic treatment to counteract the drug's negative effects. In animal studies sugammadex and lipid emulsion had a positive effect on survival in patients with calcium channel blocker toxicity. Sugammadex and intralipid increased survival in a rat model of verapamil toxicity. The combination of both drugs may decrease cardiotoxicity. Sugammadex alone or combined with 20% lipid emulsion reduce the need for inotropic agents. The mechanism requires clarification with larger studies. PMID: 27012816 [PubMed - in process] (Source: Medical Science Monitor)
Sun, 27 Mar 2016 15:12:02 +0100Authors: Jublanc C, Bruckert E Abstract Adrenal insufficiency is a rare but life-threatening disorder. Clinical manifestations include fatigue, weight loss, gastrointestinal manifestations and skin hyperpigmentation, the latter being specific of primary adrenal failure. Because of non-specific clinical features of this rare disorder, diagnosis can be delayed and adrenal failure be revealed by an acute crisis. Adrenal insufficiency can be primary (Addison disease), most frequently autoimmune, or secondary, resulting from long term administration of exogenous glucocorticoids or more rarely from pituitary disorders. Monitoring of substitutive treatment is now well codified. Patient education is very important in this chronic disease that remains associated with a persistent high risk ...
Sun, 27 Mar 2016 07:01:02 +0100Authors: Tominaga K, Fujikawa Y, Tsumoto C, Kadouchi K, Tanaka F, Kamata N, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y, Arakawa T Abstract To elucidate the role of autonomic nervous system in functional dyspepsia patients, we examined 24-h heart rate variability: the basal levels, responses after lunch, cold pressor and mental arithmetic tests, and the efficacy of an autonomic drug (tofisopam). The high-frequency component (HF: 0.15-0.40 Hz) and the ratio of HF to the low-frequency component (LF: 0.04-0.15 Hz; LF/HF ratio) were used as indicators of parasympathetic and sympathetic autonomic nervous system function. The HF component in the 24-h, daytime, and nighttime was low in 86.7%, 97.8%, and 66.7% of patients (n = 45) and the LF/HF ratio was high in 51.1%, 73.3%, and 26...
Sun, 27 Mar 2016 05:28:02 +0100CONCLUSIONS: LncRNA profiling hallmarks a moderate diagnostic value in the management of GC and that lncRNA expression patterns may potentially be utilized as auxiliary biomarkers in confirming GC. PMID: 27015554 [PubMed - as supplied by publisher] (Source: Oncotarget)
Sun, 27 Mar 2016 05:28:02 +0100Authors: Wu J, Qin H, Li T, Cheng K, Dong J, Tian M, Chai N, Guo H, Li J, You X, Dong M, Ye M, Nie Y, Zou H, Fan D Abstract Multi-drug resistance (MDR) remains a great obstacle to effective chemotherapy for gastric cancer. A number of secreted glycoproteins have been reported to be involved in the development of MDR in gastric cancer. However, whether glycosylation of secreted glycoproteins changes during MDR of gastric cancer is unclear. Our present work manifested that N-glycosites and site-specific glycoforms of secreted proteins in drug-resistant cell lines were distinctly different from those in the parental cell line for the first time. Further characterization highlighted the significance of some aberrantly glycosylated secretory proteins in MDR, suggesting that manipulating...
Sun, 27 Mar 2016 05:28:02 +0100Authors: Shen JX, Liu J, Li GW, Huang YT, Wu HT Abstract Aldehyde dehydrogenase 1 (ALDH1) consists of a family of intracellular enzymes, highly expressed in stem cells populations of leukemia and some solid tumors. Up to now, 6 isoforms of ALDH1 have been reported. However, the expression patterns and the identity of ALDH1 isoenzymes contributing to ALDH1 activity, as well as the prognostic values of ALDH1 isoenzymes in cancers all remain to be elucidated. Here, we studied the expressions of ALDH1 transcripts in gastric cancer (GC) compared with the normal controls using the ONCOMINE database. Through the Kaplan-Meier plotter database, which contains updated gene expression data and survival information of 876 GC patients, we also investigated the prognostic values of ALDH1 isoenzy...
Sun, 27 Mar 2016 05:28:02 +0100Authors: Li YJ, Dong M, Kong FM, Zhou JP, Liang D, Xue HZ Abstract We evaluated miR-371-5p expression in gastric cancer (GC) tissues and its influence on the expression of downstream genes, especially SOX2. MiR-371-5p expression (measured using qRT-PCR) was upregulated in GC tissues and correlated positively with TNM staging and lymph node (LN) metastasis. MiR-371-5p expression was higher in human GC cell lines (AGS, MKN-28, BGC-823, MGC-803, SGC-7901 and MKN-45) than in human normal gastric epithelial (GES-1) cells (all P < 0.05). MGC-803 tumor cell growth (measured with an MTT assay), migration, and invasion (measured with Transwell chamber assays) were severely inhibited in cells transfected with a miR-371-5p inhibitor, whereas they were stimulated in cells transfected with S...
Sun, 27 Mar 2016 03:07:01 +0100Authors: Arman D, Sancak S, Topcuoglu S, Karatekin G PMID: 27012229 [PubMed - as supplied by publisher] (Source: Journal of Obstetrics and Gynaecology)
Sat, 26 Mar 2016 23:00:00 +0100Publication date: Available online 26 March 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Priya Tiwari Ramucirumab is the recent addition to the list of monoclonal antibodies being tried in various malignancies. It has been approved in non-small cell lung cancer, gastric cancer and colorectal cancer after progression of one or more lines of therapies in the advanced setting. Though randomized trials have shown benefit, cost effectiveness is questionable. Moreover, the benefits shown are marginal, putting a question mark over its clinical usage. This review summarizes the latest evidence on ramucirumab. (Source: Journal of the Egyptian National Cancer Institute)
Sat, 26 Mar 2016 23:00:00 +0100We report a case of enteric fever which presented to start with as acute gastritis and then went on to develop acute pancreatitis which is a rare complication of enteric fever; along with capillary leak syndrome in the acute phase mimicking dengue shock syndrome. This unusual presentation has not been reported in Indian or foreign literature. (Source: Pediatric Infectious Disease)
Sat, 26 Mar 2016 23:00:00 +0100Conclusion Accordingly, we can conclude that rotaviral antigenemia and viremia were common in children with rotaviral diarrhea, however, the impact of rotavirus antigenemia/viremia on clinical manifestations of infection is unknown. (Source: Pediatric Infectious Disease)
Sat, 26 Mar 2016 23:00:00 +0100Publication date: Available online 26 March 2016 Source:European Polymer Journal Author(s): Adriana P. Gerola, Danielle C. Silva, Alan F.Y. Matsushita, Olga Borges, Adley F. Rubira, Edvani C. Muniz, Artur J.M. Valente Hydrogels of a natural polysaccharide composed of Gum Arabic (GA) are appropriate materials for drug delivery, since they are water soluble, nontoxic and biocompatible. In this work, the effect of methacrylation on the properties of GA as pH-responsive hydrogel has been evaluated. Modified Gum Arabic (M-GA x ), with different degrees of substitution, has been obtained by using different percentages of glycidyl methacrylate (x). It was observed that playing with the x value, gels with different properties have been found: since weak gels to gels with a dual responsive...
Sat, 26 Mar 2016 12:31:01 +0100Authors: Chapman CG, Waxman I, Siddiqui UD Abstract Despite the advances in endoscopy, endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD) remains a technically challenging procedure. Technical success rates are greater than 70%; however, the average rate of adverse events is nearly 20%, which increases to 55% when stent migration is included. Until recently, a significant difficulty with this technique was the absence of dedicated devices. Proper patient selection is of utmost importance, and EUS-PDD should be reserved for patients who have failed endoscopic retrograde pancreatography. Furthermore, EUS-PDD must be performed by experienced endoscopists who are familiar with the technique. The most common indications include chronic pancreatitis induced strictures and st...
Sat, 26 Mar 2016 12:31:01 +0100Authors: Kim EY PMID: 27012289 [PubMed - as supplied by publisher] (Source: Clinical Endoscopy)
Sat, 26 Mar 2016 12:31:01 +0100Authors: Lee SH, Hong SG, Lee KY, Park PK, Kim SD, Lee M, Yu DW, Hong MY Abstract Hemobilia is a rare gastrointestinal bleeding, usually caused by injury to the bile duct. Hemobilia after endoscopic retrograde cholangiopancreatography (ERCP) is generally self-limiting and patients will spontaneously recover, but some severe and fatal hemorrhages have been reported. ERCP-related bowel or bile duct perforation should be managed promptly, according to the type of injury and the status of the patient. We recently experienced a case of late-onset severe hemobilia in which the patient recovered after endoscopic biliary stent insertion. The problem was attributable to ERCP-related bile duct perforation during stone removal, approximately 5 weeks prior to the hemorrhagic episode. The remov...
Sat, 26 Mar 2016 12:31:01 +0100Conclusions: In gastric MALT lymphoma, the endoscopically defined polypoid type was characterized by a longer duration to CR, with a higher likelihood of recurrence, compared to the endoscopically defined diffuse infiltration or ulceration types. PMID: 27009028 [PubMed - as supplied by publisher] (Source: Clinical Endoscopy)
Sat, 26 Mar 2016 11:41:02 +0100CONCLUSIONS: All the characteristics of new levothyroxine oral liquid formulations allow to administer the drug also in patients with gastrointestinal comorbidities or patients who are already treated with other drugs. The availability of different dosages let the clinician to adapt the treatment for each individual patient. These benefits contribute to a better medication adherence and to the maintenance of normal TSH levels. In conclusion, the use of different pharmaceutical formulations represents a therapeutic approach innovative, effective and inexpensive in the treatment of the hypothyroid patient. PMID: 27015567 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Sat, 26 Mar 2016 11:11:03 +0100CONCLUSIONS: We have demonstrated by SD-OCT that morbid obesity may have a significant influence on RNFL, RGC, and CT. Morbid obesity may induce inflammatory, hormonal, and metabolic changes. PMID: 27010146 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Sat, 26 Mar 2016 05:14:12 +0100After infections were linked to tainted medical scopes, physicians pressed device maker Olympus Corp to lend them replacements. Olympus refused but offered to sell new scopes at hiked prices. Kaiser Health News (Source: Medscape Gastroenterology Headlines)
Fri, 25 Mar 2016 23:00:00 +0100Publication date: Available online 26 March 2016 Source:Journal of Pediatric Surgery Case Reports Author(s): Marcel Tafen, Nader Tehrani, Afshin A. Anoushiravani, Avinash Bhakta, Timothy G. Canty, Christine Whyte Esophagogastric fistula or double-lumen esophagus is a rare condition. There have been fewer than 15 reported cases in adults and only one reported case in the pediatric population. Esophagogastric fistulas typically develop in patients with preexisting gastrointestinal reflux, esophagogastric surgery, esophageal ulcers, or carcinoma. Our case involves a 5 year-old girl presenting with odynophagia and nocturnal cough who had a prior Nissen fundoplication. She was found to have an esophagogastric fistula. Conservative management with esophageal dilatation and proton pump in...
Fri, 25 Mar 2016 23:00:00 +0100Conclusions Insulin-DG mix is a potent anti-diabetic agent and importantly, DG extract is protective to insulin when used in prescribed combination and delivered orally. This could be a possible solution for painful subcutaneous injections. (Source: Asian Pacific Journal of Tropical Disease)
Fri, 25 Mar 2016 23:00:00 +0100Publication date: March 2016 Source:Asian Pacific Journal of Tropical Disease, Volume 6, Issue 3 Author(s): Alka Gupta, Kavita Birhman, Indira Raheja, Surender Kumar Sharma, Hemant Kumar Kar In the last decade, considerable efforts have been made to develop health promising nutritional supplements. Quercetin is a plant-derived bioflavonoid which is recently gaining scientific interest for its antioxidant free radical scavenging effects and anti-inflammatory properties. This wonder flavanol exhibits therapeutic potential in various ailments like cancer, coronary artery, asthma and alzheimer (neurodegeneration) diseases. Additional clinical uses include treatment of inflammatory conditions like gout, pancreatitis and prostatitis. It has been extensively studied for its gastroprotectiv...
Fri, 25 Mar 2016 23:00:00 +0100We thank Dr Fan and Dr Sonneveld for their comments and interest in our work. In our study, we have demonstrated a higher cumulative hepatitis B surface antigen (HBsAg) seroclearance at week 72 among chronic hepatitis B virus (HBV)-infected patients who received 48-week tenofovir disoproxil fumarate (TDF) and pegylated interferon alfa-2a (Peg-IFN) combination treatment as compared to either treatment as monotherapy.1 We agree that the overall cumulative HBsAg seroclearance rate was not very high, only 9.1%, for the combination treatment. (Source: Gastroenterology)
Fri, 25 Mar 2016 23:00:00 +0100We read with great interest the paper by Marcellin et al published in Gastroenterology.1 The authors demonstrated that combination therapy with tenofovir disoproxil fumarate (TDF) and pegylated interferon alfa-2a (Peg-IFN) for 48 weeks could result in higher rate of hepatitis B surface antigen (HBsAg) loss than either monotherapy in the multicenter international trial. However, the key question is whether the new strategy is good enough to be translated into current clinical practice. (Source: Gastroenterology)
Fri, 25 Mar 2016 23:00:00 +0100Question: A 15-month-old boy presented with afebrile convulsion and impaired consciousness owing to marked hypokalemia. He was referred by a community hospital where he had presented with a first episode of nonbilious vomiting 3 days previously. Physical examination revealed a hard, egg-sized epigastric mass. Plain radiography demonstrated a gas-distended stomach. As part of the workup for the mass, the infant underwent ultrasonography (Figure A) and abdominal computed tomography scan (Figure B, C). (Source: Gastroenterology)
Fri, 25 Mar 2016 23:00:00 +0100Question: A 69-year-old man presented with a 7-year history of abdominal pain. The pain was intermittent, with month-long asymptomatic periods, usually located in a rather small area, 2 × 3 cm, in the right upper quadrant. The pain usually had no radiation, although in some periods it had radiated to the back (following roughly the D9-10 dermatomes of the right side). The pain worsened with some movements, like getting up from a bed or a chair. Various diagnostic procedures had been previously performed: upper digestive endoscopy presented no alterations and a 5-mm tubular adenoma was found on colonoscopy; blood testing showed no abnormalities. (Source: Gastroenterology)
Fri, 25 Mar 2016 23:00:00 +0100Question: A 25-year-old man with a known chronic familial pancreatitis (proven PRSS1 mutation) visited the outpatient clinic because of persistent abdominal pain 2 months after a flare of chronic pancreatitis. Despite daily use of pain medication (weak opioid plus a nonopioid), he was not able to perform his daily activities. An abdominal magnetic resonance imaging showed a pseudocyst of 10 × 8-cm in the head of the pancreas. The pancreatic and common bile ducts were not dilated. At a multidisciplinary meeting, it was decided to endoscopically drain the pseudocyst in an attempt to relieve the pain. (Source: Gastroenterology)
Fri, 25 Mar 2016 23:00:00 +0100Question: A 56-year-old woman with history of peptic ulcer disease, diverticulosis, hypertension, and hypothyroidism presented with acute postprandial epigastric pain lasting 4-6 hours, which she describes as the worst of her life. She also reported milder similar episodes occurring over the last few months. At presentation, she was hemodynamically stable and had an unremarkable physical exam. Blood tests revealed mild leukocytosis. A computed tomography scan of the abdomen showed a type II paraesophageal hiatal hernia where a large part of the stomach was noted in the chest cavity (Figure A). (Source: Gastroenterology)
Fri, 25 Mar 2016 23:00:00 +0100Question: A 53-year-old man from Martinique (Caribbean Islands) with suspected gallbladder cancer was referred to our department. The patient had been examined with abdominal Doppler ultrasonography after 2 episodes of acute cholecystitis within the previous 5 months. The Doppler ultrasonography results showed almost complete hyperechogenicity of the acalculous gallbladder due to wall thickening. However, there was no ultrasonographic Murphy’s sign (Figure A). Liver function tests were normal. The patient had normal abdominal computed tomography (CT) results 6 months before the first episode of cholecystitis. (Source: Gastroenterology)
Fri, 25 Mar 2016 23:00:00 +0100Question: A 25-year-old woman presented to her primary care physician for mild right upper quadrant pain. Apart from the patient being an avid kickboxer, no noteworthy abdominal trauma was recalled. Because of an inconclusive ultrasound examination, showing no gallstones, together with elevated liver enzymes an abdominal magnetic resonance imaging study was ordered. A 7 × 4.5 × 4-cm mass in contact to the cecum was seen. (Source: Gastroenterology)
Fri, 25 Mar 2016 23:00:00 +0100(Source: Gastrointestinal Endoscopy)
Fri, 25 Mar 2016 23:00:00 +0100(Source: Gastrointestinal Endoscopy)
Fri, 25 Mar 2016 23:00:00 +0100(Source: Gastrointestinal Endoscopy)
Fri, 25 Mar 2016 23:00:00 +0100(Source: Gastrointestinal Endoscopy)
Fri, 25 Mar 2016 23:00:00 +0100(Source: Gastrointestinal Endoscopy)
Fri, 25 Mar 2016 23:00:00 +0100We thank Zhong and colleague for their comments that give us the possibility to further discuss the topic regarding the role of pre-operative hepatic venous pressure gradient (HVPG) in the surgical decision-making of hepatocellular carcinoma. We always have noticed a large discrepancy between the weight of guidelines recommendations and the quality and quantity of available literature that specifically studied the usefulness of HVPG for the selection of candidates for hepatectomy . This aspect is strengthened by the clinical routine: in Eastern countries, evaluation for surgery is commonly based on the indocyanine green retention rate and, in Western countries most centers do not routinely perform venous pressure measurements . (Source: Journal of Hepatology)
Fri, 25 Mar 2016 23:00:00 +0100Non-alcoholic fatty liver disease (NAFLD) typically exists in a milieu of disturbed metabolism, including increased total body adiposity, insulin resistance, impaired glucose tolerance and dyslipidemia. Cumulatively, these factors increase the risk for cardiovascular disease (CVD), and so it is not surprising that CVD is the leading cause of death in NAFLD patients. The challenge over the past decade has been to tease apart the complex and inter-dependent relationships between NAFLD and these etiological factors, to establish whether NAFLD per se increases the risk of developing CVD. (Source: Journal of Hepatology)
Fri, 25 Mar 2016 23:00:00 +0100Conclusion The study provides relevant data that can be used as input for prevention and strategies to improve the health of the ostomized population. (Source: Journal of Coloproctology)
Fri, 25 Mar 2016 23:00:00 +0100This study investigates whether Lewy pathology is present in various gastrointestinal tract tissues from Parkinson's disease patients in the prodromal phase. Methods: We used the Danish National Pathology Registry, to identify archived paraffin embedded tissue blocks from 57 Parkinson's disease patients (98 blocks) and 90 control subjects (98 blocks). We employed two different immunohistochemistry techniques visualizing aggregated α ‐synuclein and phosphorylated α ‐synuclein. Results: Thirty‐nine Parkinson's disease patients contributed tissues obtained in the prodromal disease phase, whilst 18 Parkinson's disease patients contributed tissues obtained solely after Parkinson's diagnosis. Prodromal tissues were obtained on average 7.0 years prior to diagnosis (range: 20 years – 4 m...
Fri, 25 Mar 2016 23:00:00 +0100Gastroschisis is a severe congenital anomaly the etiology of which is unknown. Research evidence supports attempted vaginal delivery for pregnancies complicated by gastroschisis in the absence of obstetric indications for cesarean delivery. (Source: American Journal of Obstetrics and Gynecology)
Fri, 25 Mar 2016 19:51:02 +0100Authors: Dobrzynska Z, Celichowski J Abstract The early phase of development of muscles stops following the disappearance of embryonic and neonatal myosin and the elimination of polyneuronal innervation of muscle fibres with the formation of motor units (MUs), but later the muscle mass still considerably increases. It is unknown whether the three types are visible among newly formed MUs soon after the early postnatal period and whether their proportion is similar to that in adult muscle. Moreover, the processes responsible for MU-force regulation by changes in motoneuronal firing rate as well as properties of motor unit action potentials (MUAPs) during maturation are unknown. Three groups of Wistar rats were investigated - 1 month old, 2 months old and the adult, 9 months old. The ...
Fri, 25 Mar 2016 19:51:02 +0100Authors: Pawlik MW, Kwiecien S, Ptak-Belowska A, Pajdo R, Olszanecki R, Suski M, Madej J, Targosz A, Konturek SJ, Korbut R, Brzozowski T Abstract The inhibition of angiotensin-converting enzyme (ACE) or the blockade of angiotensin (Ang) AT-1 receptors affords protection against acute gastric mucosal injury, but whether the major metabolite of renin-angiotensin system (RAS), Ang-(1-7), accelerates the healing process of preexisting gastric ulcers remains unknown. Previous studies documented that Ang-(1-7) acting via its own Mas receptor exerts vascular responses opposing those of Ang II. We studied the effects of the Ang-(1-7)/Mas receptor axis on the healing rate of acetic-acid-induced gastric ulcers with or without the blockade of Mas receptors by A 779 and compared it with the ef...
Fri, 25 Mar 2016 18:30:27 +0100The combination of simeprevir (SMV) and sofosbuvir (SOF) is effective treatment for patients with chronic hepatitis C virus (HCV) genotype 1 infection and cirrhosis, according to results from OPTIMIST-2. Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Fri, 25 Mar 2016 18:04:09 +0100Andrew Wakefield is back in the news, thanks to a new, controversial documentary set to premiere at the upcoming Tribeca Film Festival in New York. The film, directed by Wakefield himself, claims that the U.S. Centers for Disease Control and Prevention orchestrated a conspiracy to cover up the "true" reason for America's rising autism diagnosis rates: vaccines. This is a widely and soundly discredited assertion. Studies from the independent, non-profit Institute of Medicine, the World Health Organization and the CDC have all found that there is no link between receiving vaccines and developing autism spectrum disorder. Instead, what these studies demonstrate is that vaccines are overwhelmingly safe, with very rare cases of side effects, and that they protect children f...
Fri, 25 Mar 2016 17:35:02 +0100In conclusion, DS may act through inhibition of HIF-1α expression, which decreased ITGβ1 expression, consequently reducing tumor metastasis. PMID: 27004522 [PubMed - as supplied by publisher] (Source: Oncology Reports)
Fri, 25 Mar 2016 17:33:04 +0100Authors: Böger C, Behrens HM, Mathiak M, Krüger S, Kalthoff H, Röcken C Abstract Targeting the PD-1/PD-L1 immune checkpoint signaling is a novel promising treatment strategy in several tumor entities, and it is suggested that PD-L1/PD-1 expression is predictive for a PD-1/PD-L1 checkpoint inhibitor treatment response. We investigated the expression of PD-L1 and PD-1 by immunohistochemistry in a large and well characterized gastric cancer (GC) cohort of Caucasian patients, consisting of 465 GC samples and 15 corresponding liver metastases. Staining results were correlated with clinico-pathological characteristics and survival. PD-L1 expression was found in tumor cells of 140 GCs (30.1%) and 9 liver metastases (60%) respectively in immune cells of 411 GCs (88.4%) and 11 liver meta...
Fri, 25 Mar 2016 17:33:04 +0100In this study, we used adenoviral vector to deliver Bmi-1 shRNA driven by its own promoter to treat GC. Our results revealed that Ad-Bmi-1i could selectively silence Bmi-1 in GC cells which overexpress Bmi-1 and suppress the malignant phenotypes and stem-like properties of GC cells in vitro and in vivo. Moreover, direct injection of Ad-Bmi-1i into xenografts suppressed tumor growth and destroyed cancer cells in vivo. Ad-Bmi-1i inhibited the proliferation of GC cells mainly via inducing senescence in vitro, but it suppressed tumor through inducing senescence and apoptosis, and inhibiting angiogenesis in vivo. Bmi-1 knockdown by Ad-Bmi-1i downregulated VEGF via inhibiting AKT activity. These results suggest that Ad-Bmi-1i not only inhibits tumor growth and stem cell-like phenotype by inducin...
Fri, 25 Mar 2016 17:33:04 +0100Authors: Zhang ZY, Lu YX, Zhang ZY, Chang YY, Zheng L, Yuan L, Zhang F, Hu YH, Zhang WJ, Li XN Abstract Long non-coding RNAs (lncRNAs) are involved in kinds of human diseases, including colorectal cancer (CRC). TINCR, a 3.7 kb long non coding RNA, was associated with cell differentiation in keratinocyte and gastric cancer cells. However, little is known about the role of TINCR in regulation CRC progression. Here, we showed that lncRNA TINCR was associated with CRC proliferation and metastasis. TINCR was statistically downregulated in CRC tissues and metastatic CRC cell lines compared with their counterparts. TINCR was reversely correlated with CRC progression and promoted tumor cells growth, metastasis in vivo and in vitro. While overexpression of TINCR had opposite effect. In addi...
Fri, 25 Mar 2016 17:33:04 +0100Authors: Jolly MK, Tripathi SC, Jia D, Mooney SM, Celiktas M, Hanash SM, Mani SA, Pienta KJ, Ben-Jacob E, Levine H Abstract Epithelial-to-Mesenchymal Transition (EMT) and its reverse - Mesenchymal to Epithelial Transition (MET) - are hallmarks of cellular plasticity during embryonic development and cancer metastasis. During EMT, epithelial cells lose cell-cell adhesion and gain migratory and invasive traits either partially or completely, leading to a hybrid epithelial/mesenchymal (hybrid E/M) or a mesenchymal phenotype respectively. Mesenchymal cells move individually, but hybrid E/M cells migrate collectively as observed during gastrulation, wound healing, and the formation of tumor clusters detected as Circulating Tumor Cells (CTCs). Typically, the hybrid E/M phenotype has large...
Fri, 25 Mar 2016 17:33:04 +0100CONCLUSIONS: TLR1, TLR2, TLR4 and TLR6 are upregulated during malignant changes of esophageal columnar epithelium. Increased TLR4 expression associates with advanced stage and poor prognosis in esophageal adenocarcinoma. PMID: 27008696 [PubMed - as supplied by publisher] (Source: Oncotarget)
Fri, 25 Mar 2016 17:33:04 +0100This study aimed to elucidate the role of RUNX2 in the invasive and metastatic potentials of human gastric cancer (GC) and the underlying mechanisms. We found that the levels of RUNX2 expression in gastric cancer tissues were correlated with the differentiation degrees, invasion depth and lymph node metastasis. COX regression analysis indicated that RUNX2 was an independent prognostic indicator for GC patients. RUNX2 significantly increased the migration and invasion ability of GC cells in vitro and enhanced the invasion and metastatic potential of GC cells in an orthotopic GC model of nude mice. Mechanistically, RUNX2 directly bound to the promoter region of the gene coding for the chemokine receptor CXCR4 to enhance its transcription. CXCR4 knockdown or treatment with AMD3100, a CXCR4 in...
Fri, 25 Mar 2016 17:33:04 +0100Authors: Kim ST, Lee J, Lee SJ, Park SH, Jung SH, Park YS, Lim HY, Kang WK, Park JO Abstract We designed a single-arm, open label phase II study to determine the efficacy and toxicity of the combination of pazopanib with CapeOx (capecitabine and oxaliplatin) in metastatic /recurrent advanced gastric cancer (AGC) patients. Previously untreated AGC patients received capecitabine (850 mg/m2 bid, day 1-14) plus oxaliplatin (130 mg/m2, day 1) in combination with pazopanib (800 mg, day 1-21) every three weeks. Treatment was continued until progression of the disease or intolerable toxicity was observed. In all, 66 patients were treated with pazopanib plus CapeOx. The median age of the patients was 51.5 years (range, 23.0-77), and the median ECOG performance status was 1 (0-1). Among all ...
Fri, 25 Mar 2016 17:05:02 +0100Authors: Inatsu Y, Ohata Y, Ananchaipattana C, Latiful Bari M, Hosotani Y, Kawasaki S Abstract Fate of Escherichia coli O157 cells was evaluated when inoculated into each step after production of lightly pickled Chinese cabbage. The efficacy of surface sterilization by 100 mg/L of chlorine water for 10 min on raw leaves (6.0 log CFU/g) was 2.2 log CFU/g reduction. No meaningful change of the population of E. coli O157 (3.5 log CFU/g to 1.5 log MPN/g) contaminated into 19 kinds of products was observed. These results indicated the difficulty of estimating the viable count of the cells between contaminated on farms and further processing and storage steps. The population of E. coli O157 (3 log CFU/g to 1 log MPN/g) inoculated into the Chinese cabbage products was reduced less than 0....
Fri, 25 Mar 2016 15:42:04 +0100Authors: Yang L, Liang H, Wang Y, Gao S, Yin K, Liu Z, Zheng X, Lv Y, Wang L, Zhang CY, Chen X, Xu G, Zhang W, Zou X PMID: 27000078 [PubMed - as supplied by publisher] (Source: Protein and Cell)
Fri, 25 Mar 2016 15:40:03 +0100This study was aimed to investigating the frequency of Anaplastic lymphoma kinase (ALK) alterations in patients with gastric signet ring cell carcinoma (SRC) and the correlations between ALK alterations and the clinical-pathological features. METHODS: The expression of ALK protein was first determined in paraffin-embedded tissue specimens (FFPE) from 177 pathologically confirmed SRC patients by Ventana Immunohistochemistry (IHC). Then patients with ALK positive detected by IHC were assayed in ALK rearrangement by Fluorescence in Situ Hybridization (FISH). RESULTS: We assessed 4 of 177 cases (2.3%) as positive by IHC. 3 of the 4 patients had T4 tumors and positive nodal status, and 1 of them had metastasis. All of them were HER2 negative. All of the 4 patients were positive for ALK ...
Fri, 25 Mar 2016 15:08:52 +0100Conclusion: Increased expression of EGFR and Bcl-2 proteins in the epithelial cells and a statistically significant positive correlation between the numbers of cells expressing EGFR and Bcl-2 in H. pylori infected children could suggest increased regeneration abilities of gastric mucosa. (Source: Postepy higieny i medycyny doswiadczalnej)
Fri, 25 Mar 2016 12:34:28 +0100Are coffee drinkers at an increased risk of cirrhosis or does the opposite hold true? Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Fri, 25 Mar 2016 12:28:24 +0100Bently Barnes (center) with Dr. Victor Fox and Dr. Amit Grover, co-directors of the Pancreatic Disorders Program Four-year-old Bently Barnes needed to get ready. He opened the closet door, reached for his camouflage backpack, then scanned his bedroom for the essentials. He grabbed his favorite stuffed animal named, “Marshall,” a truck, tractor and his most prized possession – his blanket. He placed them in his backpack with care, zipped the travel bag and placed it next to his bed. Bently told his mom he was packed and ready to travel from their home in North Carolina to Boston Children’s Hospital. And he was “ready for a new belly,” he said. Early signs of chronic pancreatitis Bently’s mom, Nicole Barnes says her son’s stomach pain began well before his 2...