Last Build Date: Tue, 22 Mar 2016 08:23:04 +0100
Mon, 21 Mar 2016 00:00:00 +0100ConclusionCanagliflozin improved glycemic control, body weight, and BP in participants aged 75 and older. The overall incidence of AEs was high across treatment groups in participants aged 75 and older and higher than in those younger than 75. The safety profile of canagliflozin was generally similar in both age groups, with a higher incidence of AEs related to volume depletion observed with canagliflozin in participants aged 75 and older than in those younger than 75. These findings support canagliflozin, starting with the 100‐mg dose, as an effective therapeutic option for older adults with T2DM. (Source: Journal of the American Geriatrics Society)
Mon, 21 Mar 2016 00:00:00 +0100ConclusionDiabetes mellitus increased the risk of developing depressive symptoms in older Mexican Americans. Older Latinos with diabetes mellitus should be screened for depressive symptoms and prioritized for close follow‐up, potentially through greater reliance on team‐based models of care. (Source: Journal of the American Geriatrics Society)
Mon, 21 Mar 2016 00:00:00 +0100(Source: Journal of the American Geriatrics Society)
Mon, 21 Mar 2016 00:00:00 +0100(Source: Journal of the American Geriatrics Society)
Mon, 21 Mar 2016 00:00:00 +0100Conclusion Improvement of visual acuity and reduction in macular thickness were maintained up to the 6-month follow-up. The results of electrophysiological examinations revealed that ranibizumab injections tend to stabilize bioelectrical macular function of the outer, middle and inner retinal layers, which was impossible to recognize on the basis of visual acuity and OCT. Therefore, the electrophysiological examinations should be used as an additional objective tool for the evaluation of the anti-VEGF treatment effectiveness in DME. (Source: Documenta Ophthalmologica)
Mon, 21 Mar 2016 00:00:00 +0100CONCLUSIONS Aortic bioprostheses are a good option for haemodialysis patients requiring AVR, offering acceptable mid-term survival. The Medtronic Freestyle aortic bioprostheses could allow the implantation of larger bioprostheses inferring consequently lower mean gradients, with a potentially higher resistance to calcification and sclerosis in haemodialysis patients. (Source: Interactive CardioVascular and Thoracic Surgery)
Mon, 21 Mar 2016 00:00:00 +0100Conclusion Although 1-in-8 hypertensive patients develop NOD, mortality is increased only in the 1-in-20 who develop early NOD. Further studies are warranted to determine if early identification of such individuals should provide an alert for intensification of therapeutic interventions. (Source: European Heart Journal)
Mon, 21 Mar 2016 00:00:00 +0100ConclusionsHbA1c may not be sensitive enough for an accurate diagnosis, but it is highly specific for diagnosing overt diabetes at 6–12 weeks post‐partum in women with previous gestational diabetes mellitus.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)
Mon, 21 Mar 2016 00:00:00 +0100Conclusions The incidence rate of pediatric T1DM in Friuli Venezia Giulia has increased in the last years, and the disease is a relevant public health issue in the region. (Source: Acta Diabetologica)
Mon, 21 Mar 2016 00:00:00 +0100Conclusions These data indicate that Hsp90 may be involved in high glucose-induced islet function adaptation. (Source: Acta Diabetologica)
Mon, 21 Mar 2016 00:00:00 +0100Conclusions Rs2910164 is significantly associated with microvascular complications DN in patients with T1DM and DME in patients with T2DM. (Source: Acta Diabetologica)
Mon, 21 Mar 2016 00:00:00 +0100Abstract The literature regarding risk factors for gestational diabetes mellitus (GDM) recurrence is inconsistent. We aimed to assess the effect sizes of risk factors of GDM recurrence. We searched electronic databases (1970–2015) and bibliographies for studies that included women with GDM (index pregnancy) who had a consecutive birth. We compared the risk factors among women with and without GDM recurrence. Differences in variables measured on a continuous scale were estimated using the weighted mean difference (WMD). The standardized mean difference (SMD) was used to rate the pooled effects. For categorical variables, the pooled odds ratio was estimated. Cochran’s Q test of heterogeneity was used to choose the model for estimating the pooled effects. Fourteen cross-sectional...
Mon, 21 Mar 2016 00:00:00 +0100Retinal hemorrhage is an important finding on fundus photography. Diabetes mellitus is a cause of retinal hemorrhage, although other causes exist. We sought to better characterize the association between retinal hemorrhage and HbA1c in the Japanese population. (Source: Journal of Diabetes and Its Complications)
Mon, 21 Mar 2016 00:00:00 +0100Conclusion Self-treated hypoglycemia was relatively common in patients using basal insulin analogs, with or without bolus insulin. Whilst the frequency of hypoglycemia was greater during the daytime than at night, patients worried more about nocturnal events and this level of worry was under-estimated by physicians. Additional advice and support may be needed for both patients and prescribers, to reduce the frequency and impact of self-treated hypoglycemia. Funding Novo Nordisk. (Source: Diabetes Therapy)
Mon, 21 Mar 2016 00:00:00 +0100ConclusionsThese data are the first to implicate the association between the IL‐19 and T2DM with vascular complications, IL‐19 is significantly positively correlated with Ang‐2. IL‐19 and Ang‐2 may be involved in angiogenesis of T2DM with vascular complications.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Mon, 21 Mar 2016 00:00:00 +0100Publication date: Available online 20 March 2016 Source:Trends in Endocrinology & Metabolism Author(s): Manuel Vázquez-Carrera Insulin resistance precedes dyslipidemia and type 2 diabetes mellitus (T2DM) development. Preclinical evidence suggests that peroxisome proliferator-activated receptor (PPAR) β/δ activators may prevent and treat obesity-induced insulin resistance and T2DM, while clinical trials highlight their potential utility in dyslipidemia. This review summarizes recent mechanistic insights into the antidiabetic effects of PPARβ/δ activators, including their anti-inflammatory actions, their ability to inhibit endoplasmic reticulum (ER) stress and hepatic lipogenesis, and to improve atherogenesis and insulin sensitivity, as well as their capacity to activate path...
Mon, 21 Mar 2016 00:00:00 +0100Hematopoietic cell transplantation (HCT) survivors face a multitude of short- and long-term health complications in the years following treatment. One important health complication that is associated with significant morbidity is metabolic syndrome (MetSyn). This constellation of findings, including obesity, glucose and lipid dysmetabolism, and hypertension, place affected individuals at increased risk for type 2 diabetes mellitus, cardiovascular complications and stroke. Previous studies have linked MetSyn in HCT survivors to prior treatment; however, few have addressed the potential roles of systemic inflammation and immune system dysfunction following HCT. (Source: Biology of Blood and Marrow Transplantation)
Sun, 20 Mar 2016 18:07:30 +0100Purpose: The study was designed to investigate the influence of type 2 diabetes mellitus (T2DM) on articular syndrome and parameters of cytokines in patients with osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:29 +0100Purpose: In osteoarthritis (OA), we delineate several phenotypes depending on each risk factor. Likewise, we differentiate aging related-OA, post-trauma OA and the so called ‘metabolic phenotype’. In relation with this last phenotype, several epidemiodological and experimental findings support the hypothesis that type 2 diabetes mellitus (DM) could be an independent risk factor of OA. Likewise, we have recently reported a higher responsiveness to inflammatory stress of OA cartilage from patients with DM and enhanced IL-1β-induced inflammation in cultured chondrocytes in a high glucose (HG) environment. (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 18:07:28 +0100Purpose: Conditions such as obesity, diabetes mellitus (DM), and cardiovascular disease (CVD) are associated with osteoarthritis (OA). However, it is unknown if these associations with OA remain when these comorbidities are assessed together or over time. Therefore, we sought to examine the independent association of obesity, DM, and CVD with knee or hip symptomatic OA (sxOA) over 4 to 18 years of follow-up (involving three possible time-points). (Source: Osteoarthritis and Cartilage)
Sun, 20 Mar 2016 11:58:02 +0100We present the case of a 38 year old woman, who presented with altered mental status and biochemical alterations suggestive of diabetic ketoacidosis who was found to have a pituitary apoplexy. The low frequency of this condition coupled with an acute and usually dramatic presentation that includes non-specific symptoms makes it a diagnostic challenge. Pituitary apoplexy can simulate a wide range of neurological conditions. PMID: 26994379 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Sun, 20 Mar 2016 10:11:01 +0100CONCLUSIONS: The present meta-analysis suggests that consuming probiotics may improve glucose metabolism by a modest degree, with a potentially greater effect when the duration of intervention is ≥8 weeks, or multiple species of probiotics are consumed. PMID: 26987497 [PubMed - in process] (Source: Medicina (Kaunas))
Sun, 20 Mar 2016 00:00:00 +0100Conclusions High consumption of low fat milk, yogurt and cheese and low consumption of red meat could be beneficial for retinal microvascular health. Prospective studies are needed to verify these findings. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Sat, 19 Mar 2016 19:16:01 +0100Conclusions - The vast majority of patients with T2DM have multiple comorbidities. To ensure a comprehensive approach to patient management, the presence of multimorbidity should be considered in the context of clinical decision making. PMID: 26986190 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Sat, 19 Mar 2016 09:19:16 +0100Discussion: The care reported by patients with diabetes, which is essential to maintain their quality of life and prevent serious outcomes, seemed, in most cases, to be adequate. (Source: Revista Brasileira de Epidemiologia)
Sat, 19 Mar 2016 09:19:16 +0100Conclusions: Because these diseases are associated with modifiable risk factors, the prevention with population focus is the best strategy to reduce the burden of these diseases. (Source: Revista Brasileira de Epidemiologia)
Sat, 19 Mar 2016 06:34:47 +0100People with type II diabetes mellitus (DM) are at a high risk of falling especially during more challenging locomotor tasks such as obstacle-crossing. The current study aimed to identify the risk factors for tripping in these patients during trailing-limb ... (Source: SafetyLit)
Sat, 19 Mar 2016 02:24:35 +0100Conclusions: This is the first study with this design comparing multiple doses of insulin and continuous insulin infusion therapy in Brazil showing no significant difference in HbA1c; hypoglycemic events were less frequent during continuous insulin infusion therapy than during multiple doses of insulin and the percentage of patients who achieved a HbA1c less than 7.5% was greater during continuous insulin infusion therapy than multiple doses of insulin therapy.Resumo Objetivo: Comparar terapia com múltiplas doses de insulina e o sistema de infusão continua de insulina no tratamento da diabetes melito tipo 1. Métodos: 40 pacientes com diabetes melito tipo 1 (21 mulheres) com idades entre 10 e 20 anos (média=14,2) e duração média do diabetes de sete anos utilizaram múltiplas doses de...
Sat, 19 Mar 2016 00:20:49 +0100CONCLUSION To improve the effectiveness of the promotion of skills related to knowledge and self-care in diabetes mellitus, it is necessary to consider the contact time as a relevant factor of the educational program.Resumen OBJETIVO Verificar la relación entre el tiempo de contacto de usuarios en programas educativos y las variables conocimiento y autocuidado enDiabetes mellitus . MÉTODO Estudio longitudinal de abordaje cuantitativo, con la participación, en la fase inicial, de 263 usuarios vinculados a las Unidades Básicas de Salud de Belo Horizonte, Brasil, durante los años de 2012 y 2013. Fueron recogidos datos con relación al tiempo de contacto total de participación de los usuarios en el programa educativo, en cuanto a los conocimientos y el autocuidado en Diabetes mellitus ad...
Sat, 19 Mar 2016 00:00:00 +0100Publication date: Available online 18 March 2016 Source:Progress in Neurobiology Author(s): Julie A. Chowen, Pilar Argente-Arizón, Alejandra Freire-Regatillo, Laura M. Frago, Tamas L. Horvath, Jesús Argente The hypothalamus is crucial in the regulation of homeostatic functions in mammals, with the disruption of hypothalamic circuits contributing to chronic conditions such as obesity, diabetes mellitus, hypertension, and infertility. Metabolic signals and hormonal inputs drive functional and morphological changes in the hypothalamus in attempt to maintain metabolic homeostasis. However, the dramatic increase in the incidence of obesity and its secondary complications, such as type 2 diabetes, have evidenced the need to better understand how this system functions and how it can go ...
Sat, 19 Mar 2016 00:00:00 +0100A 78-year-old woman with a history of hypertension and diabetes mellitus presented to our emergency department because of chest pain radiating to the neck for 4days. (Source: International Journal of Cardiology)
Sat, 19 Mar 2016 00:00:00 +0100A 52-year-old male was hospitalized for investigation of a syncopal episode. His past medical history was remarkable for type II diabetes mellitus and inferior wall ST-segment elevation myocardial infarction 3months earlier, treated with primary percutaneous coronary intervention with three drug eluting stents implantation in the right coronary artery. Having excluded neurological diseases and metabolic or other common causes of syncope, the patient underwent a new coronary arteriography which depicted stent patency. (Source: International Journal of Cardiology)
Sat, 19 Mar 2016 00:00:00 +0100Heart failure is a common complication seen in patients with Type 2 Diabetes Mellitus (T2DM) and is associated with significant morbidity and mortality in these patients [1,2]. Although improved glycemic control has been shown to reduce microvascular complications in patients with T2DM , it is uncertain whether any particular hypoglycemic regimen can be considered safe from a cardiovascular standpoint. Many novel glucose-lowering strategies have recently been tested in randomized trials of patients with type 2 diabetes to establish whether use of these newer therapeutic agents translates into reductions in adverse outcomes such as risk of developing of heart failure. (Source: International Journal of Cardiology)
Sat, 19 Mar 2016 00:00:00 +0100Conclusions These results evidence that the medicinal use of T. stans could be in part because of its lipase inhibitory activity allowing to adapt the administration of this plant before meals. Also this data could help to develop a novel phytopharmaceutical drug (standardized in luteolin, chrysoeriol, and apigenin) auxiliary for the Type 2 Diabetes mellitus. Graphical abstract (Source: Journal of Ethnopharmacology)
Sat, 19 Mar 2016 00:00:00 +0100We report a 50-year-old man with type 1 diabetes mellitus who arrived at our service with a 2-month history of watery diarrhea associated with hypoglycemic attacks, abdominal pain, and weight loss of 13 kg. The diagnosis of celiac crisis was made based on diarrhea leading to dehydration, severe metabolic and electrolyte abnormalities, and subsequent improvement after introduction of a gluten-free diet. (Source: International Journal of Diabetes in Developing Countries)
Sat, 19 Mar 2016 00:00:00 +0100This study was conducted to determine the prevalence, types, and associations of hypogonadism in Nigerian men with established type 2 diabetes mellitus. The study was a cross-sectional observational work, which was conducted at the Lagos University Teaching Hospital (LUTH). The participants consisted of 108 men with type 2 DM and 56 non-diabetic controls. A questionnaire was used to obtain demographic data while the Androgen Deficiency in Aging Male (ADAM) questionnaire was administered to elicit symptoms of hypogonadism. The enzyme-linked immunosorbent assay (ELISA) method was used to test for serum-free testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, and estradiol. Other investigations done included fasting lipid profile, fasting plasma glucose, and...
Sat, 19 Mar 2016 00:00:00 +0100Few studies have examined the association between adherence to the DASH (Dietary Approaches to Stop Hypertension) or Mediterranean (MED) diets and prevalence of gestational diabetes mellitus (GDM). The aim of the present study was to evaluate the associations the between DASH and MED diets with GDM. (Source: Nutrition)
Sat, 19 Mar 2016 00:00:00 +0100Patients who undergo solid organ transplantation may have preexisting diabetes mellitus (DM), develop new-onset DM after transplantation (NODAT), or have postoperative hyperglycemia that resolves shortly after surgery. Although insulin is usually used to control hyperglycemia in the hospital, following discharge most of the usual diabetes oral and parenteral medications can be used in treatment. However, when there are comorbidities such as impaired kidney or hepatic function, or heart disease, special precautions may be necessary. In addition, drug-drug interactions, such as drugs interacting with CYP3A4 enzyme pathway, require additional consideration because of possible interaction with immunosuppressive drug metabolism. (Source: Medical Clinics of North America)
Sat, 19 Mar 2016 00:00:00 +0100Diseases associated with obesity such as type 2 diabetes mellitus (T2DMT2D), hypertension and dyslipidaemiadyslipidemia are common and defined as Metabolic Syndrome (MetSMetS). The aim of this study was to evaluate long-term effects of Laparoscopic Roux-en-Y Gastric Bypass (LRYGBP) in morbidly obese patients with MetSMetS. (Source: Surgery for Obesity and Related Diseases)
Fri, 18 Mar 2016 23:15:02 +0100Authors: Ohara N, Kaneko M, Nishibori T, Sato K, Furukawa T, Koike T, Sone H, Kaneko K, Kamoi K Abstract A 65-year-old Japanese man presented to our hospital in June 2013 with a 6-day history of fever and fatigue, a 24-h history of thirst, and polyuria. His temperature was 37.8°C and he was alert. However, laboratory tests revealed severe hyperglycemia, undetectable C-peptide levels, and diabetic ketoacidosis. Serum antibody testing confirmed a Coxsackie virus A2 infection. A variety of viral infections are reported to be involved in the development of fulminant type 1 diabetes mellitus (FT1D). Our patient is the first reported case of FT1D associated with Coxsackie virus A2 infection and supports the etiological role of common viral infections in FT1D. PMID: 26984083 [PubMed...
Fri, 18 Mar 2016 20:20:22 +0100The rising incidence of obesity and metabolic diseases such as diabetes mellitus and cardiovascular disease in adolescents and young adults is of grave concern. Recent studies favor a role of lifestyle factors over genetics in the perpetuation of inflammation, insulin resistance and oxidative stress, which are pathophysiologic processes common to the above diseases; furthermore, the importance of dietary factors in addition to calories and physical activity in these processes is being increasingly recognized. Advanced glycation end products (AGEs) belong to a category of dietary oxidants which have been implicated in the pathogenesis of inflammation, oxidative stress, insulin resistance, β-cell failure and endothelial dysfunction. This paper reviews the studies of AGEs with a focus on the...
Fri, 18 Mar 2016 10:41:02 +0100Conclusions and relevance In routine clinical practice, adding a DPP-4 inhibitor to MET is associated with an increased, earlier requirement for treatment intensification compared to adding an SU or TZD. Adding a TZD to MET resulted in the most durable glycaemic response. Key messages The Agency for Healthcare Research and Quality has suggested that the durability of glycaemic response after treatment intensification is best investigated using well-designed long-term observational studies. In routine clinical practice, among patients with T2DM receiving a second line glucose lowering treatment as add-on to MET, the addition of a Thiazolidinediones is associated with the most durable glycaemic response, followed by a Sulfonylurea and then a DPP-4 inhibitor. Factors associated with earlier d...
Fri, 18 Mar 2016 10:41:02 +0100CONCLUSIONS: This subgroup analysis demonstrated that DM significantly increased the risk of adverse events after implantation of CoCr-SES, but the general safety and efficacy performance of CoCr-SES in both diabetic and non-diabetic patients was satisfying and comparable with other types of new-generation drug-eluting stents. Key messages The overall rate of adverse clinical events in both diabetic and non-diabetic patients was <10%, indicating a satisfying long-term safety and efficacy performance of CoCr-SES, even in high-risk diabetic patients. DM significantly increased the risk of MACE (HR 1.3; 95% CI: 1.0-1.6) in patients undergoing CoCr-SES implantation. PMID: 26980503 [PubMed - as supplied by publisher] (Source: Annals of Medicine)
Fri, 18 Mar 2016 03:28:02 +0100CONCLUSIONS: FC-mixture tubes glucose concentrations were preserved up to 4h storage at RT. We confirmed that NaF alone does not allow immediate glycolysis inhibition in real life pre-centrifugation storage conditions (up to 340 minutes). FC-Mixture should be used exclusively for glucose determination in laboratories unable to implement the recommended blood samples' treatment. PMID: 26981020 [PubMed - in process] (Source: Biochemia Medica)
Fri, 18 Mar 2016 00:00:00 +0100Publication date: Available online 17 March 2016 Source:Pharmacological Research Author(s): Christian Leporini, Anna Pisano, Emilio Russo, Graziella D’Arrigo, Giovambattista de Sarro, Giuseppe Coppolino, Davide Bolignano Chronic kidney disease (CKD) represents an important health problem worldwide and the search for new therapeutic approaches for retarding CKD progression is a timely issue. Recent evidence suggest that the anti-inflammatory and hemorrheologic drug Pentoxifylline (PTX), may produce favorable effects on kidney function. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to ascertain whether PTX derivatives, alone or in combination to other treatments, may be useful in slowing down disease progression in patients with diabetic...
Fri, 18 Mar 2016 00:00:00 +0100Conclusions Our UDS data revealed that DM is associated with impaired DC in women without BOO. Moreover, longer DM duration and poor glycemic control were associated with impaired DC. (Source: International Urogynecology Journal and Pelvic Floor Dysfunction)
Fri, 18 Mar 2016 00:00:00 +0100This study aims to determine the effect of LLLT (He-Ne and Ga-Al-As laser) on the process of wound healing in the hard palate among diabetic and non-diabetic mice. 90 adult male mice were divided into six groups. Type 1 Diabetes Mellitus was induced in three groups by means of injection of STZ. Of these, one group was irradiated with He-Ne laser (DH group), one with Ga-Al-As laser (DG group) and one did not undergo any LLLT (DC group). The remaining groups were non-diabetic which were allotted to laser therapy with He-Ne laser (NH group) or with Ga-Al-As laser (NG group) or no LLLT (NC group). Five animals from each group were killed on the third, seventh, and 14days after surgery, and biopsies were made for histological analysis. On the 3rd and 7th day after the surgery, the number of pol...
Fri, 18 Mar 2016 00:00:00 +0100A predisposing factor for development of the hyperglycemic state of gestational diabetes mellitus (GDM) is obesity. We previously showed that increasing maternal obesity is associated with significant reductions in placental mitochondrial respiration. MicroRNA (miR)-143 has been previously shown to regulate the metabolic switch from oxidative phosphorylation to aerobic glycolysis in cancer tissues. We hypothesized that mitochondrial respiration is reduced and aerobic glycolysis is upregulated via changes in miR-143 expression in the placenta of women with GDM. Placental tissue was collected at term from women with A1GDM (controlled by diet), A2GDM (controlled by medication), and BMI-matched controls (CTRL). miR-143 expression was measured by RT-PCR. Expression of mitochondrial complexes, t...
Fri, 18 Mar 2016 00:00:00 +0100Conclusions This is the first report to demonstrate that PD-L1 deficiency accelerated islet allograft rejection and regulated recipient alloimmune responses. (Source: PLoS One)
Fri, 18 Mar 2016 00:00:00 +0100Conclusion: Patients with a continuous-flow LVAD who develop a GIB secondary to GIAD have a higher rate of major bleeding, multiple bleeding events, and require more transfusions to achieve stabilization compared to patients who do not have GIAD.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Fri, 18 Mar 2016 00:00:00 +0100Authors: Rodrigues PG, Leite-Moreira AF, Falcão-Pires I Abstract Heart failure (HF) is a systemic disease that can be divided into HF with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). HFpEF accounts for over 50% of all HF patients and is typically associated to high prevalence of several comorbidities, including hypertension, diabetes mellitus, pulmonary hypertension, obesity and atrial fibrillation. Myocardial remodeling occurs both in HFrEF and HFpEF and it involves changes in cardiac structure, myocardial composition, myocyte deformation, and multiple biochemical and molecular alterations that impact heart function and its reserve capacity. Understanding the features of myocardial remodeling has become a major objective for limiting or reversi...
Fri, 18 Mar 2016 00:00:00 +0100CONCLUSIONS: -In patients with DM, continued thienopyridine beyond 1-year after coronary stenting is associated with reduced risk of MI, although this benefit is attenuated when compared with patients without DM. Clinical Trial Registration Information-ClinicalTrials.gov. Identifier: NCT00977938. PMID: 26994121 [PubMed - as supplied by publisher] (Source: Circulation)
Fri, 18 Mar 2016 00:00:00 +0100CONCLUSION: ALP and BALP are equally accurate albeit weak predictors of BMD in ESRD patients, both at baseline and longitudinally. The dissociation between stable BMD and increasing ALP and BALP may possibly reflect increased soft tissue calcifications with time on dialysis. PMID: 26994005 [PubMed - as supplied by publisher] (Source: Journal of Nephrology)
Thu, 17 Mar 2016 18:08:43 +0100Conclusions: Our results support that preoperative, intraoperative, and postoperative factors are associated with AKI-CS. Ejection fraction, BMI, acute myocardial infarction, type of surgery, and congestive heart failure were not absolutely associated with AKI.Cardiorenal Med 2016;6:237-250 (Source: Cardiorenal Medicine)
Thu, 17 Mar 2016 17:27:02 +0100CONCLUSION: The results suggest DAMA is safe and effective in the management of DFUs, but additional research is needed. PMID: 26978860 [PubMed - in process] (Source: Wounds)
Thu, 17 Mar 2016 15:01:05 +0100CONCLUSIONS: Carotid atherosclerosis is very common in stable ambulatory patients with CAD regularly taking statins. The risk is higher in patients with peripheral arterial disease, a greater number of involved coronary arteries, and older age at onset of CAD. PMID: 26979002 [PubMed - in process] (Source: The Israel Medical Association Journal)
Thu, 17 Mar 2016 11:22:16 +0100Three of the 15 major contributors to disease burden in older people are diabetes, major depressive disorder and dementia.1 Diabetes and depression occur before the onset of risk factors for all-cause dementia, Alzheimer disease and vascular dementia.2 Moreover, depression and diabetes have also been shown to have a bidirectional risk effect. While diabetes may increase the risk of depression, the association in the depression-to-diabetes direction is stronger,3 showing that depression frequently occurs before diabetes. The aim of Katon et al's paper is to study the risk for all-cause dementia among persons with diabetes mellitus (DM), depression or both compared with people who had neither illness. Katon et al conducted a population-b...
Thu, 17 Mar 2016 10:34:51 +0100Conclusions: Compared with NDS, DS had increased BBB disruption defined by the presence of PE. A different form of the relationship between admission NIHSS and UO in NDS, BBB disruption was related with UO in diabetic patients after stroke.Cerebrovasc Dis 2016;42:49-56 (Source: Cerebrovascular Diseases)
Thu, 17 Mar 2016 05:44:02 +0100CONCLUSIONS Our study showed higher incidence of colorectal cancer in diabetics compared to non-diabetics. The occurrence of colorectal cancer in diabetic patients may be associated with elevated IGFs-related protein expression level. PMID: 26976474 [PubMed - in process] (Source: Medical Science Monitor)
Thu, 17 Mar 2016 04:23:43 +0100Conclusions: Routine measurement of serum gamma-glutamyl transpeptidase and/or CA19-9 levels and imaging examinations every 12 months (or 6 months, if possible) are recommended during follow-up for DM, HT, and DL to detect ICC at an early stage.Liver Cancer 2016;5:107-120 (Source: Liver Cancer)
Thu, 17 Mar 2016 00:00:00 +0100This study revealed an increase in the body fat index and a decrease in the lean mass index in T1DM children. (Source: International Journal of Diabetes in Developing Countries)
Thu, 17 Mar 2016 00:00:00 +0100Conclusions Our study indicated an association between increased risk for new-onset diabetes mellitus and statin use. Because the benefits of statins in prevention of morbidity and mortality in patients with ACS are well-established, clinical decision making should not be changed for patients with existing cardiovascular disease in whom statin therapy is recommended. (Source: Canadian Journal of Diabetes)
Thu, 17 Mar 2016 00:00:00 +0100Key Clinical Message While chronic pulmonary aspergillosis (CPA), pulmonary tuberculosis (PTB), and Klebsiella pneumoniae pneumonia co‐infection is rare, we present a 50‐year‐old woman with uncontrolled diabetes who presented with these three diseases. There is considerable overlap in symptoms of PTB and CPA. Treatment with antifungals, anti‐tuberculosis therapy, and antibiotics is beneficial. While chronic pulmonary aspergillosis (CPA), pulmonary tuberculosis (PTB), and Klebsiella pneumoniae pneumonia co‐infection is rare, we present a 50‐year‐old woman with uncontrolled diabetes who presented with these three diseases. There is considerable overlap in symptoms of PTB and CPA. Treatment with antifungals, anti‐tuberculosis therapy, and antibiotics is beneficial. (Source: C...
Thu, 17 Mar 2016 00:00:00 +0100Conclusions A healthy ND is able to modify the gene expression in PBMCs after a 2hOGTT. However, more studies are needed to clarify the biological and clinical relevance of these findings. (Source: Genes and Nutrition)
Thu, 17 Mar 2016 00:00:00 +0100Publication date: Available online 15 March 2016 Source:International Journal of Pediatrics and Adolescent Medicine Author(s): Noman Ahmad, Osama A. Bawazir Obesity is generally considered an adult disease, although there has been a constant increase in the prevalence of overweight and obese children in the last few decades. Childhood obesity is not limited to developed countries, with increasing numbers being reported from developing countries as well as from Saudi Arabia. Young populations with obesity suffer from similar comorbidities as obese adults, including type 2 diabetes mellitus, dyslipidemia, obstructive sleep apnea, polycystic ovarian syndrome, pseudotumor cerebri and fatty liver disease. Recent advances in weight loss surgery have given hope to obese adolescents who are re...
Thu, 17 Mar 2016 00:00:00 +0100Conclusions: Maternal heavy smoking (≥25 cigarettes/day) during pregnancy was associated with higher risk of gestational diabetes in the daughter. Further studies are warranted to confirm our findings and to elucidate the underlying mechanisms. (Source: International Journal of Epidemiology)
Thu, 17 Mar 2016 00:00:00 +0100Conclusion: ER stress inhibition normalizes myogenic response and improves vascular function in type 2 diabetes. Therefore, ER stress could be a potential target for cardiovascular diseases in diabetes mellitus. This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Thu, 17 Mar 2016 00:00:00 +0100Summary Metformin, an oral hypoglycemic agent, has been used for decades to treat type 2 diabetes mellitus. Recent studies indicate that mice treated with metformin live longer and have fewer manifestations of age‐related chronic disease. However, the molecular mechanisms underlying this phenotype are unknown. Here, we show that metformin treatment increases the levels of the microRNA‐processing protein DICER1 in mice and in humans with diabetes mellitus. Our results indicate that metformin upregulates DICER1 through a post‐transcriptional mechanism involving the RNA‐binding protein AUF1. Treatment with metformin altered the subcellular localization of AUF1, disrupting its interaction with DICER1 mRNA and rendering DICER1 mRNA stable, allowing DICER1 to accumulate. Consistent with ...
Thu, 17 Mar 2016 00:00:00 +0100ConclusionsThis study indicated that there is no significant difference in the risk of developing type II DM between MDD patients with and without SGA exposure. More studies focused on the benefit‐risk assessment of SGA treatment in patients with MDD are warranted. (Source: Depression and Anxiety)
Thu, 17 Mar 2016 00:00:00 +0100Insulin is the mainstay of current treatment for patients with type 1 diabetes mellitus (T1DM). Due to increasing insulin resistance, insulin doses are often continually increased, which may result in weight gain for patients. Medications currently approved for the treatment of type 2 diabetes offer varying mechanisms of action that can help to reduce insulin resistance and prevent or deter weight gain. A MEDLINE search was conducted to review literature evaluating the use of metformin, alpha-glucosidase inhibitors, pioglitazone, glucagon-like peptide 1 agonists, dipeptidyl peptidase, and sodium-dependent glucose transporter 2 inhibitors, in patients with T1DM. Varying results were found with some benefits including reductions in hemoglobin A1c, decreased insulin doses, and favorable effec...
Thu, 17 Mar 2016 00:00:00 +0100Conclusion: Dapagliflozin is effective for the treatment of type 2 diabetes. (Source: Journal of Pharmacy Practice)
Thu, 17 Mar 2016 00:00:00 +0100Conclusions: Our study does not detect a substantial association between the use of methimazole and risk of acute pancreatitis on the basis of systematic analysis. There appears to be a discrepancy between case reports and our systematic analysis about the association between the use of methimazole and risk of acute pancreatitis. (Source: Indian Journal of Pharmacology)
Thu, 17 Mar 2016 00:00:00 +0100We describe a case of a 78-year-old man with a background of untreated diabetes mellitus that developed into hyperosmolar hyperglycemic state (HHS), which was complicated by pneumomediastinum. DKA and HHS are similar conditions that result in poor nutrition and Kussmaul breathing due to metabolic acidosis. (Source: The American Journal of Emergency Medicine)
Thu, 17 Mar 2016 00:00:00 +0100We report a 16-month-old male, a youngest case of genetically confirmed TRMA syndrome in Indian phenotype, born to consanguineous parents. We found a homozygous pathogenic variant in exon 2 of the SLC19A2 gene, c.314G>A (p.Gly105Glu). The anaemia showed a good response to daily thiamine doses and was able to avoid unwanted blood transfusion. There was no benefit with regard to insulin requirement. Early detection of hearing impairment and referral to audiological treatment was possible. The report indicates that TRMA should be considered as a differential diagnosis for patients presenting with suggestive clinical symptoms which would have tremendous impact on patient management if identified early. (Source: International Journal of Diabetes in Developing Countries)
Thu, 17 Mar 2016 00:00:00 +0100The tumor necrosis factor α (TNF-α) family of inflammatory molecules plays a crucial role in the pathogenesis of type 2 diabetes mellitus (DM2) complications. TNF-α soluble receptors 1 (sTNFR1) and 2 (sTNFR2) have been associated with chronic kidney disease in DM2 patients. This cross-sectional study intended to determine serum concentrations of sTNFR1 and sTNFR2 in Colombian patients and correlated them with various clinical variables, especially kidney function. (Source: Journal of Diabetes and Its Complications)
Thu, 17 Mar 2016 00:00:00 +0100Conclusions Patients in our population with vitamin D deficiency had higher TG levels. Long-term follow-up should be performed to understand the potential impact of such levels on diabetes-related complications. (Source: Endocrinologia y Nutricion)
Thu, 17 Mar 2016 00:00:00 +0100Introduction The prevalence of gestational diabetes mellitus (GDM) is rising in the UK. Good glycaemic control improves maternal and neonatal outcomes. Frequent clinical review of patients with GDM by healthcare professionals is required owing to the rapidly changing physiology of pregnancy and its unpredictable course. Novel technologies that allow home blood glucose (BG) monitoring with results transmitted in real time to a healthcare professional have the potential to deliver good-quality healthcare to women more conveniently and at a lower cost to the patient and the healthcare provider compared to the conventional face-to-face or telephone-based consultation. We have developed an integrated GDm-health management system and aim to test the impact of using this system on maternal glycae...
Thu, 17 Mar 2016 00:00:00 +0100Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been sho...
Thu, 17 Mar 2016 00:00:00 +0100To analyze inflammatory markers, adipokines, and hepatokines in obese adolescents with and without type 2 diabetes mellitus (T2DM). (Source: The Journal of Pediatrics)
Thu, 17 Mar 2016 00:00:00 +0100Conclusion OAGB in a non-obese diabetic rat model improves glycemic control, with a significant decrease in glucose and insulin levels. This reduction without weight loss suggests a surgically induced enhancement of pancreatic function. It appears that this improvement occurs, although the GLP-1 levels were significantly increased only in the early stages. The paradoxical response of glucagon should be further evaluated. (Source: Obesity Surgery)
Thu, 17 Mar 2016 00:00:00 +0100Conclusions Liver fibrosis is frequent in morbidly obese patients with concurrent DM and/or MeS. Increased serum levels of IR, P1NP, lower osteocalcin, and VDD are clinically relevant predictors of fibrosis. Consequently, we suggest that patients with preoperative presence of these markers are at increased risk for liver fibrosis and should be monitored closely. (Source: Obesity Surgery)
Thu, 17 Mar 2016 00:00:00 +0100Conclusions The improvement of the pattern of cytokine production, as evidenced by postoperative rise in serum adiponectin concentration, might play a role in T2DM remission after bariatric surgery. (Source: Obesity Surgery)
Thu, 17 Mar 2016 00:00:00 +0100CONCLUSIONS: BTX-A has an excellent safety profile and may be efficient for patients with symptomatic TN not suited for conventional therapies. PMID: 26992044 [PubMed - as supplied by publisher] (Source: Headache)
Wed, 16 Mar 2016 11:32:01 +0100Authors: Chiao HY, Wang CY, Wang CH Abstract Salmonella can cause extra-intestinal focal infections as well as gastrointestinal problems. A few cases of Salmonella skin and soft tissue infection have been documented in immunocompromised patients such as persons with type 2 diabetes and poor glycemic control. A case study is presented of a 30-year-old man with a 10-year history of poorly controlled (HbA1C 11.7%) diabetes mellitus who presented with a ruptured nodule resulting in a wound with signs of infection over his anterior chest region of 1-month duration. He had been taking amoxycillin/clavulanate for the week previous to presentation at the authors' facility. Following sharp debridement, the ulcerative wound deteriorated and a chest wall abscess developed. Bacterial culture r...
Wed, 16 Mar 2016 07:35:03 +0100This report demonstrates potent anti-apoptotic and cyto-protective activity of Enicostemma littorale MeOH extract (EL MeOH ext.) against 50 μM H2O2 in isolated rat Islets. Materials and methods In this study, the whole plant methanolic extract of EL with doses 0.25-4 mg/mL each for the preincubation duration of 0.5-4 h against 50 μM H2O2 were tested for optimum protective dose and time by Trypan blue dye exclusion assay. Islet intracellular reactive oxygen species (ROS) was quantified by DCFDA staining and cell death using PS/PI & FDA/PI staining. Further, comet assay, biochemical assessment of caspase-3 and antioxidant enzyme activities along with immunoblotting of PARP-1, caspase-3, TNF-α activation and p-P38 MapK (stress kinase) induction was performed. Results The optimi...
Wed, 16 Mar 2016 00:00:00 +0100Conclusion Type 1 DM is associated with subclinical LV systolic dysfunction and worse RV systolic function, which can be detected with 2D STE. (Source: European Journal of Echocardiography)
Wed, 16 Mar 2016 00:00:00 +0100Conclusions SF-36 scores at baseline, age, and previous PCI were significant predictors of subjective health status 10years post-PCI. Specifically, the SF-36 score at baseline was an important predictor. Thus assessment of subjective health status at baseline is useful as an indicator to predict long-term subjective health status. Subjective health status becomes better by optimal medical treatment, cardiac rehabilitation and psychosocial support. This is the first study determining predictors of subjective health status 10years post-PCI. (Source: IJC Heart and Vasculature)
Wed, 16 Mar 2016 00:00:00 +0100Abstract The obesity epidemic has fueled an epidemic of prediabetes and type 2 diabetes mellitus in women of childbearing age. This paper examines the state of the science on preconception and pregnancy management of women with type 2 diabetes to optimize outcomes for the women and their infants. In addition, the consequence of fetal programming as a result of suboptimal maternal glycemic control is discussed. The paper focuses on type 2 diabetes, not type 1 diabetes or gestational diabetes. Management of women with type 2 diabetes includes preconception counseling, preconception weight management and weight loss, proper weight gain during pregnancy, self-monitoring of blood glucose levels, medication, medical nutrition therapy, and exercise. (Source: Current Diabetes Reports)
Wed, 16 Mar 2016 00:00:00 +0100Abstract This review discusses available literature on the diagnosis and management of intrauterine growth restriction (IUGR) in women with type 1 diabetes. IUGR is diagnosed when ultrasound-estimated fetal weight is below the 10th percentile for gestational age. IUGR diagnosis implies a pathologic process behind low fetal weight. IUGR in pregnancy complicated by type 1 diabetes is usually caused by placental dysfunction related to maternal vasculopathy. Prevention of IUGR should ideally start before pregnancy. Strict glycemic control and intensive treatment of nephropathy and hypertension are essential. Low-dose aspirin initiated before 16 gestational weeks can also reduce IUGR risk in women with vasculopathy. Umbilical and uterine artery Doppler studies can guide diagnosis and ...
Wed, 16 Mar 2016 00:00:00 +0100Conclusion More patients treated with canagliflozin experienced reductions in both HbA1c and body weight compared with glimepiride for up to 104 weeks. Canagliflozin was generally well tolerated in patients with T2DM when used in combination with metformin. Clinical Trial Registration ClinicalTrials.gov identifier, NCT00968812. Funding Janssen Research & Development, LLC. (Source: Diabetes Therapy)
Wed, 16 Mar 2016 00:00:00 +0100This study analyzed the perioperative (30-day) outcomes of CEA in diabetic patients aged ≥80 years. (Source: Journal of Vascular Surgery)
Wed, 16 Mar 2016 00:00:00 +0100Bariatric surgery improves glycemic metabolism, even before weight loss. However, this improvement in carbohydrate metabolism is not always sufficient for complete remission of type 2 diabetes mellitus (T2D). The previous inflammatory state of the adipose tissue may affect this improvement. (Source: Surgery for Obesity and Related Diseases)
Wed, 16 Mar 2016 00:00:00 +0100S. S. Lee, Y. W. Yang, T. H. Tsai, Y. H. Kuo, H. Y. Chuang, C. C. Lee and T. F. Hsieh (Source: The Journal of Urology)
Wed, 16 Mar 2016 00:00:00 +0100To evaluate the association between microvascular complications and nocturia among Japanese patients with type 2 diabetes mellitus. (Source: Urology)
Wed, 16 Mar 2016 00:00:00 +0100Authors: Stitham J, Hwa J Abstract Prostacyclin (PGI2) and other metabolites of arachidonic acid are increasingly recognized for their role in the pathophysiology of human disease. A growing body of evidence from randomized controlled trials, studies of human prostacyclin receptor (hIP) variants, and IP-receptor knockout studies in mice has shown that PGI2 may have a protective effect on atherothrombotic risk. Increased risk of atherosclerosis and thrombotic sequelae may be attributed, in part, to downregulation of the prostacyclin pathway. Clinical studies with nonsteroidal antiinflammatory drugs (NSAIDs) that were selective for the cyclooxygenase-2 (COX-2) isoenzyme, although protective of mucosa in the gastrointestinal tract, first alluded to a potential role of PGI2 in atheroth...
Wed, 16 Mar 2016 00:00:00 +0100The epidemic nature of type 2 diabetes mellitus (T2DM), along with the downsides of current treatments, has raised the need for therapeutic alternatives. (Source: Metabolism - Clinical and Experimental)
Wed, 16 Mar 2016 00:00:00 +0100We report our initial experience of an off-pump total arterial minimally invasive coronary arterial bypass grafting (MICS CABG) with the use of bilateral internal thoracic arteries (BITA) and the right gastroepiproic artery. A 47-year old male with renal dysfunction secondary to diabetes mellitus was admitted for heart failure due to severe triple-vessel disease. Off-pump MICS CABG with total arterial grafts was elected because the patient refused to undergo median sternotomy due to the strong desire to regain the baseline function promptly. Total arterial grafts were selected to maximize the potential long-term outcome. There were no postoperative complications except temporary dialysis. Postoperative coronary computed tomography revealed the patency of all grafts. Our experience suggests...
Wed, 16 Mar 2016 00:00:00 +0100Authors: Park Y, Franchi F, Rollini F, Angiolillo DJ Abstract Diabetes mellitus (DM) is a key risk factor for recurrent atherothrombotic events in patients with acute coronary syndrome (ACS) and in those undergoing percutaneous coronary intervention (PCI). The prothrombotic milieu that characterizes patients with DM underscores the importance of oral antithrombotic therapy for secondary prevention of recurrent events in these patients. Indeed, dual antiplatelet therapy (DAPT) with aspirin and the P2Y12inhibitor clopidogrel, which has represented the mainstay of treatment for many years, has significantly reduced the incidence of recurrent atherothrombotic events. However, recurrence rates in DM patients still remain high despite this treatment regimen, which may be partly related t...
Wed, 16 Mar 2016 00:00:00 +0100CONCLUSIONS: Elders with pre-existing health conditions were more vulnerable to excess mortality risk to hot and/or cold temperature. Preventative measures should target on elders with chronic health problems. PMID: 26994463 [PubMed - as supplied by publisher] (Source: Environmental Research)
Tue, 15 Mar 2016 16:19:04 +0100ConclusionsSpontaneous MI following a medically managed UA/NSTEMI event is common. Baseline characteristics can be used to predict subsequent risk of spontaneous MI in this population. These findings provide insight into the long-term natural history of medically managed UA/NSTEMI patients and could be used to optimize risk stratification and treatment of these patients. (A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects [TRILOGY ACS]; NCT00699998) (Source: Journal of the American College of Cardiology)