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MedWorm: Diabetes



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Diabetes category.



Last Build Date: Tue, 22 Mar 2016 08:23:13 +0100

 



Impact of Growth Restriction and Other Prenatal Risk Factors on Cord Blood Iron Status in Prematurity

Tue, 22 Mar 2016 07:43:43 +0100

Conclusion: Growth-restricted preterm newborns are at risk for poor iron endowment, likely due to uteroplacental insufficiency. Other RFs were less impactful on iron status of premature newborns than in term newborns, likely reflecting that disruptive effects of RFs are more impactful in the third trimester. Understanding RFs for poor iron endowment is important for clinical recognition and treatment of premature babies. (Source: Journal of Pediatric Hematology Oncology)

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Performance and safety of an integrated bihormonal artificial pancreas for fully automated glucose control at home

Tue, 22 Mar 2016 07:13:18 +0100

ConclusionsThe results of this pilot study suggest that our integrated artificial pancreas provides better glucose control than insulin pump therapy in patients with type 1 diabetes at home and that the treatment is safe. (Source: Diabetes, Obesity and Metabolism)



Sex‐specific incidence rates and risk factors of insulin resistance and β–cell dysfunction: a decade follow‐up in a Middle Eastern population

Tue, 22 Mar 2016 07:13:16 +0100

ConclusionsModifiable risk factors are related to the incidence of insulin resistance and β‐cell dysfunction, which can be prevented with proper strategies although the difference between men and women should be taken into account.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)



Incretin-Based Therapy for Diabetes What a Cardiologist Needs to Know

Tue, 22 Mar 2016 05:43:04 +0100

Incretin-based therapies are effective glucose-lowering drugs that have an increasing role in the treatment of type 2 diabetes because of their efficacy, safety, and ease of use. Both glucagon-like peptide–1 receptor agonists and dipeptidyl peptidase–4 inhibitors are commonly used for glycemic control as adjuncts to metformin, other oral antiglycemic agents, or insulin. Glucagon-like peptide–1 receptor agonists may have additional effects, such as weight loss, that may be advantageous in obese patients. There is a large body of evidence from randomized controlled clinical trials supporting the cardiovascular safety of dipeptidyl peptidase–4 inhibitors and some glucagon-like peptide–1 receptor agonists, at least in the short term. However, concerns have been raised, particularly r...



The application of information theory for the research of aging and aging-related diseases

Tue, 22 Mar 2016 00:00:00 +0100

This article reviews the application of information-theoretical analysis, employing measures of entropy and mutual information, for the study of aging and aging-related diseases. The research of aging and aging-related diseases is particularly suitable for the application of information theory methods, as aging processes and related diseases are multi-parametric, with continuous parameters coexisting alongside discrete parameters, and with the relations between the parameters being as a rule non-linear. Information theory provides unique analytical capabilities for the solution of such problems, with unique advantages over common linear biostatistics. Among the age-related diseases, information theory has been used in the study of neurodegenerative diseases (particularly using EEG time ser...



Effect of Royal Jelly Intake on Serum Glucose, Apolipoprotein A-I (ApoA-I), Apolipoprotein B (ApoB) and ApoB/ApoA-I Ratios in Patients with Type 2 Diabetes: A Randomized, Double-Blind Clinical Trial Study

Tue, 22 Mar 2016 00:00:00 +0100

Conclusions These data suggest that RJ intake may have desirable effects on serum glucose, Apo-A-I concentrations and ApoB/ApoA-I ratios in people with type 2 diabetes. (Source: Canadian Journal of Diabetes)

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Exercises for the Cat in Your Life

Mon, 21 Mar 2016 21:28:41 +0100

Most pets in the U.S. today are overweight or obese. According to the most recent information from the Association for Pet Obesity Prevention (APOP), over half of U.S. dogs are overweight, and almost 60 percent of cats are as well. Obesity is its own disease, and it's also the root cause of several other painful, debilitating diseases including hip dysplasia, arthritis, diabetes, hypertension, respiratory problems, kidney disease, and a significant reduction in both quantity and quality of life. While most dog guardians can think of several ways to help their pet get physically fit, people who share their lives with a corpulent cat often have no idea how to get beefy Bella to follow a workout routine. Here are my favorite recommendations for getting the overweight feline in your life up an...



Factors associated with operative treatment of enthesopathy of the extensor carpi radialis brevis origin.

Mon, 21 Mar 2016 21:15:02 +0100

CONCLUSIONS: It seems likely that an emphasis on the preferences and values of the patient rather than the surgeon would decrease the variation in surgery rates for eECRB observed in this study. Methods for optimizing the influence of patient preferences and values on decision making (eg, decision aids) merit additional study. PMID: 26995457 [PubMed - as supplied by publisher] (Source: Hand Surgery)



Cost Variation in Diabetes Care across Dutch Care Groups?

Mon, 21 Mar 2016 18:34:20 +0100

ConclusionsDifferences between care groups exist when an appropriate indicator and a sophisticated aggregation technique is used. Currently applied benchmarking may have unfair consequences for some care groups. (Source: Health Services Research)



New study may lead to improved treatment of type 2 diabetes

Mon, 21 Mar 2016 16:35:44 +0100

Worldwide, 400 million people live with diabetes. Patients with diabetes mostly fall into one of two categories, type 1 diabetics, triggered by autoimmunity at a young age, and type 2 diabetics, caused by metabolic dysfunction of the liver. New research has discovered that a common genetic defect in beta cells may underlie both forms of diabetes. (Source: ScienceDaily Headlines)



Measurement’s Meaning in Diabetes Care Gets Attention

Mon, 21 Mar 2016 15:07:01 +0100

Quantifying progress in diabetes care, by measuring blood pressure, A1C, and cholesterol, laid the foundation of healthcare’s movement from fee-for-service toward payment for value. Today, diabetes...(PRWeb March 21, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13279178.htm (Source: PRWeb: Medical Pharmaceuticals)

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Is A1c Variability a Useful Measure in Diabetes?Is A1c Variability a Useful Measure in Diabetes?

Mon, 21 Mar 2016 14:54:37 +0100

Fluctuations in glycated hemoglobin levels have been suggested as an independent risk factor for diabetic complications, but new studies cast doubts on that concept. Medscape Diabetes & Endocrinology (Source: Medscape Diabetes Headlines)



Re: Das et al.: Diabetic macular edema: pathophysiology and novel therapeutic targets (Ophthalmology 2015;122:1375-94)

Mon, 21 Mar 2016 14:34:41 +0100

This article is interesting because it outlines the role that inflammation plays in the pathogenesis of diabetic macular edema (DME) and discusses the novel therapies in this disease area. Das et al refer to the efficacy and safety of the fluocinolone acetonide (FAc) implant (ILUVIEN), which is licensed for the treatment of DME in a number of European countries and the United States. However, the authors do not present the data relating to ILUVIEN specifically (with a release rate of 0.2 μg FAc per day1), nor do they outline the differences between licensed indications in Europe and the United States. (Source: Ophthalmology)



Reply

Mon, 21 Mar 2016 14:34:41 +0100

We thank Dr Hall for his critical appraisal and interest in our article. His comment about the use of the fluocinolone acetonide (FA) implant in Europe based on results in chronic diabetic macular edema (DME) for 3 years and in the United States based on results in DME for 2 years is well taken. (Source: Ophthalmology)



The Glucose-Lowering Effect of Metformin Resides in the GutThe Glucose-Lowering Effect of Metformin Resides in the Gut

Mon, 21 Mar 2016 13:25:52 +0100

In this report, the authors examine the glucose-lowering actions of metformin formulations -- focusing on the gut-based mechanisms. Diabetes Care (Source: Medscape Today Headlines)



Diabetic who drank FIVE energy drinks a day loses 8st after doctors warning

Mon, 21 Mar 2016 11:21:46 +0100

Victoria Stean, 24, from Milton Keynes, was at risk of losing her vision after being diagnosed with retinopathy, linked to her diabetes and poor diet. She slimmed to 11st 7lbs and is now a size 10. (Source: the Mail online | Health)

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Medical News Today: Diabetes: rare, genetic form may need different treatment

Mon, 21 Mar 2016 10:00:00 +0100

A rare, genetic form of diabetes, often misdiagnosed as type 2 because it shares some symptoms, may require different treatment, as the current ones destroy insulin cells. (Source: Health News from Medical News Today)



Exposure to DDT linked to higher risk of obesity, diabetes and slow metabolism

Mon, 21 Mar 2016 06:00:00 +0100

(NaturalNews) Females exposed to DDT in the womb may be more likely to suffer from obesity and diabetes in middle age, according to a study conducted by researchers from the University of California-Davis and Mount Sinai School of Medicine, funded by the National Institute of Environmental... (Source: NaturalNews.com)



Cost-effectiveness of continuous subcutaneous insulin infusion in people with type 2 diabetes in the Netherlands.

Mon, 21 Mar 2016 04:13:01 +0100

CONCLUSIONS: In the Netherlands, CSII represents a cost- effective option in patients with type 2 diabetes who continue to have poorly-controlled HbA1c despite optimization of MDI. Since the ICER falls below the willingness-to-pay threshold of EUR 80,000 per QALY gained, CSII is likely to represent good-value for money in the treatment of poorly-controlled T2D patients compared with MDI. PMID: 26985982 [PubMed - as supplied by publisher] (Source: Journal of Medical Economics)



Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions Our results suggest that several type 2 diabetes susceptibility SNPs in genes involved in WNT signaling may interact with dietary fiber intake on type 2 diabetes incidence. (Source: Genes and Nutrition)



Efficacy and Safety of Canagliflozin in Individuals Aged 75 and Older with Type 2 Diabetes Mellitus: A Pooled Analysis

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionCanagliflozin improved glycemic control, body weight, and BP in participants aged 75 and older. The overall incidence of AEs was high across treatment groups in participants aged 75 and older and higher than in those younger than 75. The safety profile of canagliflozin was generally similar in both age groups, with a higher incidence of AEs related to volume depletion observed with canagliflozin in participants aged 75 and older than in those younger than 75. These findings support canagliflozin, starting with the 100‐mg dose, as an effective therapeutic option for older adults with T2DM. (Source: Journal of the American Geriatrics Society)

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Diabetes Mellitus as a Risk Factor for Development of Depressive Symptoms in a Population‐Based Cohort of Older Mexican Americans

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionDiabetes mellitus increased the risk of developing depressive symptoms in older Mexican Americans. Older Latinos with diabetes mellitus should be screened for depressive symptoms and prioritized for close follow‐up, potentially through greater reliance on team‐based models of care. (Source: Journal of the American Geriatrics Society)



Community‐Acquired Pneumonia in Elderly Adults with Type 2 Diabetes Mellitus

Mon, 21 Mar 2016 00:00:00 +0100

(Source: Journal of the American Geriatrics Society)






The macular function and structure in patients with diabetic macular edema before and after ranibizumab treatment

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion Improvement of visual acuity and reduction in macular thickness were maintained up to the 6-month follow-up. The results of electrophysiological examinations revealed that ranibizumab injections tend to stabilize bioelectrical macular function of the outer, middle and inner retinal layers, which was impossible to recognize on the basis of visual acuity and OCT. Therefore, the electrophysiological examinations should be used as an additional objective tool for the evaluation of the anti-VEGF treatment effectiveness in DME. (Source: Documenta Ophthalmologica)



MicroRNA 152 regulates hepatic glycogenesis by targeting PTEN

Mon, 21 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: FEBS Journal)

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The Challenges of Mobile Health Regulation

Mon, 21 Mar 2016 00:00:00 +0100

The field of mobile health (mHealth), involving the use of smartphones, tablets, and other wireless devices to collect, aggregate, or disseminate health information, has been heralded as a health care revolution. Applications (apps) and sensors—many included in consumer-focused wearables, and others more specifically targeting diseases or therapeutics—present an array of potential tools and opportunities for people, patients, and physicians to monitor and improve health. For example, apps have the potential to help patients and physicians remotely diagnose acute conditions, like bacterial pharyngitis or otitis media. Remote sensor devices may assist in monitoring chronic conditions, like the blood glucose levels of patients with diabetes, or blood pressure in patients with hypertension...



Multiple Healthful Dietary Patterns and Type 2 Diabetes in the Women's Health Initiative

Mon, 21 Mar 2016 00:00:00 +0100

The relationship between various diet quality indices and risk of type 2 diabetes (T2D) remains unsettled. We compared associations of 4 diet quality indices—the Alternate Mediterranean Diet Index, Healthy Eating Index 2010, Alternate Healthy Eating Index 2010, and the Dietary Approaches to Stop Hypertension (DASH) Index—with reported T2D in the Women's Health Initiative, overall, by race/ethnicity, and with/without adjustment for overweight/obesity at enrollment (a potential mediator). This cohort (n = 101,504) included postmenopausal women without T2D who completed a baseline food frequency questionnaire from which the 4 diet quality index scores were derived. Higher scores on the indices indicated a better diet. Cox regression was used to estimate multivariate hazard ratios ...



IJERPH, Vol. 13, Pages 343: EQ-5D-5L in the General German Population: Comparison and Evaluation of Three Yearly Cross-Section Surveys

Mon, 21 Mar 2016 00:00:00 +0100

Health-related quality of life (HRQoL) is a key measure for evaluating health status in populations. Using the recent EQ-5D-5L for measurement, this study analyzed quality of life results and their stability over consecutive population surveys. Three cross-section surveys for representative samples of the general German population from 2012, 2013, and 2014 were evaluated using the EQ-5D-5L descriptive system and valuation by the Visual Analog Scale (VAS). Aggregated sample size reached 6074. The dimension with the highest prevalence of problems was pain/discomfort (31.7%). Compared with 2012 (59.3%), the percentage of participants in the best health state increased slightly in 2013 (63.4%) and 2014 (62%). Over the 3-year period, diabetes and heart disease had the strongest negative influen...



Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells

Mon, 21 Mar 2016 00:00:00 +0100

Publication date: Available online 21 March 2016 Source:Molecular Aspects of Medicine Author(s): Giuseppe Maulucci, Bareket Daniel, Ofir Cohen, Yossef Avrahami, Shlomo Sasson Nutrient sensing mechanisms of carbohydrates, amino acids and lipids operate distinct pathways that are essential for the adaptation to varying metabolic conditions. The role of nutrient-induced biosynthesis of hormones is paramount for attaining metabolic homeostasis in the organism. Nutrient overload attenuate key metabolic cellular functions and interfere with hormonal-regulated inter- and intra-organ communication, which may ultimately lead to metabolic derangements. Hyperglycemia and high levels of saturated free fatty acids induce excessive production of oxygen free radicals in tissue and cells. This phen...



Medtronic Freestyle aortic bioprosthesis: a potential option for haemodialysis patients

Mon, 21 Mar 2016 00:00:00 +0100

CONCLUSIONS Aortic bioprostheses are a good option for haemodialysis patients requiring AVR, offering acceptable mid-term survival. The Medtronic Freestyle aortic bioprostheses could allow the implantation of larger bioprostheses inferring consequently lower mean gradients, with a potentially higher resistance to calcification and sclerosis in haemodialysis patients. (Source: Interactive CardioVascular and Thoracic Surgery)

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Contrasting mortality risks among subgroups of treated hypertensive patients developing new-onset diabetes

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion Although 1-in-8 hypertensive patients develop NOD, mortality is increased only in the 1-in-20 who develop early NOD. Further studies are warranted to determine if early identification of such individuals should provide an alert for intensification of therapeutic interventions. (Source: European Heart Journal)



New-onset diabetes in hypertensive patients and mortality: timing is everything

Mon, 21 Mar 2016 00:00:00 +0100

(Source: European Heart Journal)



Reasons why patients referred to diabetes education programmes choose not to attend: a systematic review

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionNew and innovative methods of delivering diabetes education are required which address the needs of people with diabetes whilst maintaining quality and efficiency.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)



One–hour post–load plasma glucose level during the OGTT predicts mortality: observations from the Israel Study of Glucose Intolerance, Obesity and Hypertension

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsA 1 h glucose value > 155 mg/dl predicts mortality even when the 2 h level is < 140 mg/dl. However, when the 2 h level is in the impaired glucose tolerance range, the hazard for mortality rises significantly independent of the 1 h value. Individuals at risk for developing diabetes could be identified earlier using the 1 h threshold value of 155 mg/dl, which could avert progression to diabetes and increased mortality.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)



Association between prediabetes and risk of chronic kidney disease: a systematic review and meta‐analysis

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionPrediabetes is modestly associated with an increase in chronic kidney disease risk, but this remains to be robustly confirmed. Chronic kidney disease screening among people with prediabetes, and aggressive management of prediabetes in those with chronic kidney disease may be warranted.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)

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Pancreas volume and fat fraction in children with Type 1 diabetes

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsOur findings do not indicate that pancreatic atrophy in Type 1 diabetes is associated with an increased pancreatic fat fraction, unlike some other diseases featuring reduced pancreatic volume. We speculate that our results may support the hypotheses that much of pancreatic atrophy in Type 1 diabetes occurs before the clinical onset of the disease and that exogenous insulin administration decelerates pancreatic atrophy after diabetes onset.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)



Statins, regulatory T cells and diabetes

Mon, 21 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)



Diagnostic value of haemoglobin A1c in post‐partum screening of women with gestational diabetes mellitus

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsHbA1c may not be sensitive enough for an accurate diagnosis, but it is highly specific for diagnosing overt diabetes at 6–12 weeks post‐partum in women with previous gestational diabetes mellitus.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)



Diagnostic performance of HbA1c for diabetes in Arab vs. European populations: a systematic review and meta‐analysis

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsGiven the low sensitivity of HbA1c in the high‐risk Arab American population, we recommend a combination of glucose‐based and HbA1c testing to ensure an accurate and timely diagnosis of diabetes.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)



Causes of death in childhood‐onset Type 1 diabetes: long‐term follow‐up

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsThere was no change in mortality attributable to acute complications during the study period. To reduce premature mortality in people with childhood‐onset diabetes focus should be on prevention of acute complications. Male gender implied increased risk.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)

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The incidence rate and prevalence of pediatric type 1 diabetes mellitus (age 0–18) in the Italian region Friuli Venezia Giulia: population-based estimates through the analysis of health administrative databases

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions The incidence rate of pediatric T1DM in Friuli Venezia Giulia has increased in the last years, and the disease is a relevant public health issue in the region. (Source: Acta Diabetologica)



Potential role of Hsp90 in rat islet function under the condition of high glucose

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions These data indicate that Hsp90 may be involved in high glucose-induced islet function adaptation. (Source: Acta Diabetologica)



A dizygotic twin pregnancy in a MODY 3-affected woman

Mon, 21 Mar 2016 00:00:00 +0100

Discussion A MODY 3 foetus needs a near-normal maternal glycemic control, because the exposure to intrauterine hyperglycemia can lead to an earlier age of diabetes onset. Neonatal hypoglycemia is generally observed in MODY 1 infants, but it is possible to hypothesize that some HNF-1α mutations could lead to a functionally impaired protein that might dysregulate HNF-4α expression determining hypoglycemia. (Source: Acta Diabetologica)



A single-nucleotide polymorphism in the MicroRNA - 146a gene is associated with diabetic nephropathy and sight-threatening diabetic retinopathy in Caucasian patients

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions Rs2910164 is significantly associated with microvascular complications DN in patients with T1DM and DME in patients with T2DM. (Source: Acta Diabetologica)



Prior knowledge of blood glucose meter download improves the accuracy of verbal self-reported blood glucose in teenagers with type I diabetes at ski camp

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions This study demonstrates an improvement in accuracy and reliability of verbally reported SMBG, following a simple intervention of ensuring participants were aware of a meter download at the completion of camp. This intervention could be easily incorporated into adolescent diabetes camp safety protocols and may provide an easy, low-cost way of improving verbally reported SMBG accuracy and therefore safety on camp. (Source: Acta Diabetologica)

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Risk factors of gestational diabetes mellitus recurrence: a meta-analysis

Mon, 21 Mar 2016 00:00:00 +0100

Abstract The literature regarding risk factors for gestational diabetes mellitus (GDM) recurrence is inconsistent. We aimed to assess the effect sizes of risk factors of GDM recurrence. We searched electronic databases (1970–2015) and bibliographies for studies that included women with GDM (index pregnancy) who had a consecutive birth. We compared the risk factors among women with and without GDM recurrence. Differences in variables measured on a continuous scale were estimated using the weighted mean difference (WMD). The standardized mean difference (SMD) was used to rate the pooled effects. For categorical variables, the pooled odds ratio was estimated. Cochran’s Q test of heterogeneity was used to choose the model for estimating the pooled effects. Fourteen cross-sectional...



Morning cortisol levels and glucose metabolism parameters in moderate and severe obstructive sleep apnea patients

Mon, 21 Mar 2016 00:00:00 +0100

In conclusion, our study showed that morning plasma cortisol levels measured at 8 a.m. were significantly lower in severe OSA patients than those in moderate OSA group and controls. Morning plasma cortisol levels showed a negative correlation with AHI and oxygen desaturation index. Additionally, this study confirmed the evidence of glucose metabolism impairment in moderate and severe OSA patients, with more pronounced effect in the severe OSA patients group. (Source: Endocrine)



Differences in clinical characteristics between patients with and without type 2 diabetes hospitalized with a first myocardial infarction

Mon, 21 Mar 2016 00:00:00 +0100

To explore differences in clinical characteristics of patients with and without type 2 diabetes (T2DM) hospitalized with a first myocardial infarction (MI). (Source: Journal of Diabetes and Its Complications)



Relationship between HbA1c and risk of retinal hemorrhage in the Japanese general population: the Circulatory Risk in Communities Study (CIRCS)

Mon, 21 Mar 2016 00:00:00 +0100

Retinal hemorrhage is an important finding on fundus photography. Diabetes mellitus is a cause of retinal hemorrhage, although other causes exist. We sought to better characterize the association between retinal hemorrhage and HbA1c in the Japanese population. (Source: Journal of Diabetes and Its Complications)



Sense of mastery as mediator buffering psychological distress among people with diabetes

Mon, 21 Mar 2016 00:00:00 +0100

The purpose of this study was to examine the association between diabetes with or without other comorbid somatic diseases and depression and anxiety, and to explore the mediating role of sense of mastery and social support. (Source: Journal of Diabetes and Its Complications)

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Self-Treated Hypoglycemia in Type 2 Diabetes Mellitus: Results from the Second Wave of an International Cross-Sectional Survey

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion Self-treated hypoglycemia was relatively common in patients using basal insulin analogs, with or without bolus insulin. Whilst the frequency of hypoglycemia was greater during the daytime than at night, patients worried more about nocturnal events and this level of worry was under-estimated by physicians. Additional advice and support may be needed for both patients and prescribers, to reduce the frequency and impact of self-treated hypoglycemia. Funding Novo Nordisk. (Source: Diabetes Therapy)



Utility of hypertriglyceridemic‐waist phenotype for predicting incident type 2 diabetes: the Isfahan Diabetes Prevention Study

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsThese data provides further evidence that HTW phenotype was a robust predictor of T2D in high‐risk individuals in Iran and the predictive power was not higher than that of simple enlarge WC normal TG, emphasize the importance of enlarged WC to the development of T2D.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)



Interleukin‐19 and angiopoietin‐2 contributes to angiogenesis of type 2 diabetes mellitus

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsThese data are the first to implicate the association between the IL‐19 and T2DM with vascular complications, IL‐19 is significantly positively correlated with Ang‐2. IL‐19 and Ang‐2 may be involved in angiogenesis of T2DM with vascular complications.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)



Wogonin attenuates diabetic cardiomyopathy through its anti-inflammatory and anti-oxidative properties

Mon, 21 Mar 2016 00:00:00 +0100

Publication date: Available online 21 March 2016 Source:Molecular and Cellular Endocrinology Author(s): Shahzad Khan, Deling Zhang, Yemin Zhang, Mingxin Li, Changhua Wang Among diabetic cardiovascular complications cardiomyopathy is major event which if not well controlled culminates in cardiac failure. Wogonin from the root of Scutellaria baicalensis Georgi has shown specific anti-diabetes bioactivity. However, its effect on diabetic complications remains unclear. The main purpose of this study is to investigate the potential effects of wogonin on diabetic cardiomyopathy and to figure out its underlying mechanism. We found that wogonin administration suppressed hyperglycemia, improved cardiac function, and mitigated cardiac fibrosis in STZ-induced diabetic mice. Wogonin supplementa...



Unraveling the Effects of PPARβ/δ on Insulin Resistance and Cardiovascular Disease

Mon, 21 Mar 2016 00:00:00 +0100

Publication date: Available online 20 March 2016 Source:Trends in Endocrinology & Metabolism Author(s): Manuel Vázquez-Carrera Insulin resistance precedes dyslipidemia and type 2 diabetes mellitus (T2DM) development. Preclinical evidence suggests that peroxisome proliferator-activated receptor (PPAR) β/δ activators may prevent and treat obesity-induced insulin resistance and T2DM, while clinical trials highlight their potential utility in dyslipidemia. This review summarizes recent mechanistic insights into the antidiabetic effects of PPARβ/δ activators, including their anti-inflammatory actions, their ability to inhibit endoplasmic reticulum (ER) stress and hepatic lipogenesis, and to improve atherogenesis and insulin sensitivity, as well as their capacity to activate path...

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Metabolic Syndrome After Hematopoietic Cell Transplantation: At the Intersection of Treatment Toxicity and Immune Dysfunction

Mon, 21 Mar 2016 00:00:00 +0100

Hematopoietic cell transplantation (HCT) survivors face a multitude of short- and long-term health complications in the years following treatment. One important health complication that is associated with significant morbidity is metabolic syndrome (MetSyn). This constellation of findings, including obesity, glucose and lipid dysmetabolism, and hypertension, place affected individuals at increased risk for type 2 diabetes mellitus, cardiovascular complications and stroke. Previous studies have linked MetSyn in HCT survivors to prior treatment; however, few have addressed the potential roles of systemic inflammation and immune system dysfunction following HCT. (Source: Biology of Blood and Marrow Transplantation)



Musculoskeletal Health Conditions Represent a Global Threat to Healthy Aging: A Report for the 2015 World Health Organization World Report on Ageing and Health.

Sun, 20 Mar 2016 19:24:03 +0100

Authors: Briggs AM, Cross MJ, Hoy DG, Sànchez-Riera L, Blyth FM, Woolf AD, March L Abstract Persistent pain, impaired mobility and function, and reduced quality of life and mental well-being are the most common experiences associated with musculoskeletal conditions, of which there are more than 150 types. The prevalence and impact of musculoskeletal conditions increase with aging. A profound burden of musculoskeletal disease exists in developed and developing nations. Notably, this burden far exceeds service capacity. Population growth, aging, and sedentary lifestyles, particularly in developing countries, will create a crisis for population health that requires a multisystem response with musculoskeletal health services as a critical component. Globally, there is an emphasis on m...



Metabolic profiles associated with radiographic knee osteoarthritis in a population-based cohort of middle-aged women

Sun, 20 Mar 2016 18:07:32 +0100

Purpose: Osteoarthritis (OA) is associated with significant risk of cardiovascular disease, dyslipidaemia, type 2 diabetes and central obesity, suggesting early metabolic dysregulation. The exact mechanism underlying those associations is unknown, but recent literature points towards deregulation of several metabolic pathways. Understanding those links could open new avenues advancing biomarker discovery and future targeted intervention. Systemic metabolomic profiling, also called metabolomics, gives a comprehensive snapshot of metabolic activity by measuring levels of molecules involved in different metabolic pathways. (Source: Osteoarthritis and Cartilage)



Diabetes-accelerated experimental osteoarthritis is prevented by MTOR inhibition

Sun, 20 Mar 2016 18:07:32 +0100

The objective of this study was to determine how diabetes affects cartilage integrity and whether pharmacological activation of autophagy has disease-modifying efficacy in experimental-induced OA in diabetic mice. (Source: Osteoarthritis and Cartilage)



Long term type 1 diabetes is associated with hand pain but not with structural hand osteoarthritis features – The Dialong hand study

Sun, 20 Mar 2016 18:07:31 +0100

Purpose: Previous studies have shown an association between diabetes and hand osteoarthritis (OA). However, these studies have not discriminated between type 1 and type 2 diabetes. This makes it challenging to isolate the independent effect of hyperglycaemia per se on the development of hand OA. Type 1 diabetes is a purer model disease of hyperglycaemia than type 2 diabetes. Our aim was therefore to explore whether having long term type 1 diabetes is associated with a higher prevalence of radiographic hand OA, erosive hand OA and increased hand pain, -dysfunction and -stiffness. (Source: Osteoarthritis and Cartilage)

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Is waist circumference a better predictor of incident symptomatic radiographic knee osteoarthritis, radiographic knee osteoarthritis and knee pain than body mass index over 10 years?

Sun, 20 Mar 2016 18:07:31 +0100

Purpose: The current obesity epidemic is leading to a rise in non-communicable diseases (NCDs) such as diabetes, hypertension, cardio-vascular diseases (CVD), cancer and musculoskeletal conditions like osteoarthritis (OA). Although body mass index (BMI) is the most useful population-level measure of obesity, it does not account for body composition or fat distribution, which is better detected with waist circumference (WC) measurement. A large WC indicates an android fat distribution with greater amounts of fat tissue around the trunk and abdomen, known as central obesity or ‘apple shape’ being directly linked to increases in CVD. (Source: Osteoarthritis and Cartilage)



Metabolic risk factors were not associated with greater amounts of radiographic hand OA progression over 6-years in a community-dwelling population

Sun, 20 Mar 2016 18:07:31 +0100

Purpose: Hand OA progression has been found to be heterogeneous with some individuals remaining stable for many years whilst others undergo substantial structural change over short periods. Currently there is limited evidence on the risk factors for hand OA progression. While metabolic risk factors (obesity, diabetes, metabolic syndrome, the number of metabolic factors) have been associated with prevalent hand OA only obesity has been examined in relation to hand OA incidence and progression and conflicting associations have been found. (Source: Osteoarthritis and Cartilage)



The influence of type 2 diabetes mellitus on the course of osteoarthritis

Sun, 20 Mar 2016 18:07:30 +0100

Purpose: The study was designed to investigate the influence of type 2 diabetes mellitus (T2DM) on articular syndrome and parameters of cytokines in patients with osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)



Investigating the effects of high-glucose exposure on DNA methylation and gene transcription in musculoskeletal cells

Sun, 20 Mar 2016 18:07:30 +0100

Purpose: It is well established that elevated glucose exposure is a major factor in the progression of the ageing process in the vascular system. There is a growing body of evidence that suggests similar effects in the musculoskeletal system. A trend showing increasing levels of glucose consumption has been shown globally over the past 50 years, with a postulated link to a similar growth in metabolic disorders and diabetes incidence. The list of secondary pathologies associated with diabetes, characterised by chronic elevated blood glucose levels, has been extended in recent years to include musculoskeletal disorders such as joint-stiffening and osteoarthritis. (Source: Osteoarthritis and Cartilage)



Impairment of nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis in cartilage from diabetic subset: role of hyperglycemic environment

Sun, 20 Mar 2016 18:07:29 +0100

Purpose: In osteoarthritis (OA), we delineate several phenotypes depending on each risk factor. Likewise, we differentiate aging related-OA, post-trauma OA and the so called ‘metabolic phenotype’. In relation with this last phenotype, several epidemiodological and experimental findings support the hypothesis that type 2 diabetes mellitus (DM) could be an independent risk factor of OA. Likewise, we have recently reported a higher responsiveness to inflammatory stress of OA cartilage from patients with DM and enhanced IL-1β-induced inflammation in cultured chondrocytes in a high glucose (HG) environment. (Source: Osteoarthritis and Cartilage)

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Symptomatic OA predicts 12-year incidence of type 2 diabetes: role of pain induced sleep deprivation

Sun, 20 Mar 2016 18:07:28 +0100

Purpose: Type 2 diabetes (T2D) is a common comorbidity among individuals affected by large joint osteoarthritis (OA). Recent studies have shown that having T2D increases the prospective risk of total knee replacement. The role of OA and pain on incidence of T2D has not been explored. Disturbed sleep is a known risk factor of T2D and is frequently seen in people who suffer from chronic pain therefore an effect of OA on T2D may be mediated by pain induced sleep deprivation. The aim was to assess the role of radiographic OA, joint pain, and sleep deprivation on the prospective risk of developing T2D. (Source: Osteoarthritis and Cartilage)



Comorbid conditions and the presence or development of symptomatic lower-extremity osteoarthritis in a community-based longitudinal study

Sun, 20 Mar 2016 18:07:28 +0100

Purpose: Conditions such as obesity, diabetes mellitus (DM), and cardiovascular disease (CVD) are associated with osteoarthritis (OA). However, it is unknown if these associations with OA remain when these comorbidities are assessed together or over time. Therefore, we sought to examine the independent association of obesity, DM, and CVD with knee or hip symptomatic OA (sxOA) over 4 to 18 years of follow-up (involving three possible time-points). (Source: Osteoarthritis and Cartilage)



Metabolic alterations in ZDF rats induces mild cartilage degeneration of the knee joint

Sun, 20 Mar 2016 18:07:28 +0100

This study evaluates whether the metabolic syndrome contributes in the onset of OA in the ZDF rat model. (Source: Osteoarthritis and Cartilage)



Targeting a metabolic OA in vivo model by a novel dual amylin calcitonin receptor agonist, KBP-056

Sun, 20 Mar 2016 18:07:27 +0100

Purpose: Salmon calcitonin (sCT), a hormone acting through CT and amylin receptors, have in multiple preclinical models been demonstrated to improve bone homeostasis and attenuate joint destruction, in part through the anti-resorptive property. In addition, sCT have recently been shown to have a positive effect on obesity and diabetes. These properties may be particularly beneficial for certain OA patients whose disease is driven by obesity and an unhealthy metabolism. Through a larger screening program we identified a novel synthetic peptide mimicking sCT that activates the CT and amylin receptors with higher potency. (Source: Osteoarthritis and Cartilage)



Classifying patients in peritoneal dialysis by mass spectrometry-based profiling.

Sun, 20 Mar 2016 17:58:02 +0100

Authors: Araújo JE, Jorge S, Magriço R, Costa TE, Ramos A, Reboiro-Jato M, Fdez-Riverola F, Lodeiro C, Capelo JL, Santos HM Abstract Protein equalization with dithiothreitol, protein depletion with acetonitrile and the entire proteome were assessed in conjunction with matrix assisted laser desorption ionization time of flight mass spectrometry-based profiling for a fast and effective classification of patients with renal insufficiency. Two case groups were recruited as proof of concept, patients with chronic glomerulonephritis and diabetic nephropathy. Two key tools were used to develop this approach: protein concentration with centrifugal concentrator tubes with 10KDa cut-off membranes and chemical assisted protein equalization with dithiothreitol or chemical assisted protein de...

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Direct spectral analysis of tea samples using 266nm UV pulsed laser-induced breakdown spectroscopy and cross validation of LIBS results with ICP-MS.

Sun, 20 Mar 2016 17:58:02 +0100

Authors: Gondal MA, Habibullah YB, Baig U, Oloore LE Abstract Tea is one of the most common and popular beverages spanning vast array of cultures all over the world. The main nutritional benefits of drinking tea are its anti-oxidant properties, presumed protection against certain cancers, inhibition of inflammation and possible protective effects against diabetes. Laser induced breakdown spectrometer (LIBS) was assembled as a powerful tool for qualitative and quantitative analysis of various brands of tea samples using 266nm pulsed UV laser. LIBS spectra for six brands of tea samples in the wavelength range of 200-900nm was recorded and all elements present in our tea samples were identified. The major toxic elements detected in several brands of tea samples were bromine, chromium ...



Rare cause of non-healing foot wound - acral lentiginous melanoma. Case Report.

Sun, 20 Mar 2016 11:58:02 +0100

Authors: Gerslova A, Pokorna A, Stukavcova A, Veverkova L Abstract The etiology of skin integrity disorders of the lower extremities can be very diverse. In addition to common diagnoses such as venous ulcers with ischemic etiology, decubitus ulcers and diabetic foot syndrome, ulceration of a malignant etiology must also be considered. Malignant melanoma is one of the most dangerous forms of skin cancer and, although rare, may cause foot lesions. The most frequently encountered type of melanoma on acral parts of the limbs is the rare acral lentiginous variant, which only occurs in 2-10% of all melanoma types. Clinical manifestation ranges from cutaneous surface erosion to ulceration with surrounding hyperkeratosis, which can cause considerable differential diagnostic difficulties in...



Pituitary apoplexy presenting as diabetic ketoacidosis: A great simulator? Case Report.

Sun, 20 Mar 2016 11:58:02 +0100

We present the case of a 38 year old woman, who presented with altered mental status and biochemical alterations suggestive of diabetic ketoacidosis who was found to have a pituitary apoplexy. The low frequency of this condition coupled with an acute and usually dramatic presentation that includes non-specific symptoms makes it a diagnostic challenge. Pituitary apoplexy can simulate a wide range of neurological conditions. PMID: 26994379 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)



Effect of probiotics on glucose metabolism in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials.

Sun, 20 Mar 2016 10:11:01 +0100

CONCLUSIONS: The present meta-analysis suggests that consuming probiotics may improve glucose metabolism by a modest degree, with a potentially greater effect when the duration of intervention is ≥8 weeks, or multiple species of probiotics are consumed. PMID: 26987497 [PubMed - in process] (Source: Medicina (Kaunas))



Healthy Planet Essential for Global Health

Sun, 20 Mar 2016 05:25:58 +0100

When it comes to human health, it is time to rethink the notion of a balanced diet. We use an area the size of South America to grow our crops and an area the size of Africa for our livestock. On this scale, it is no surprise food production is the single largest driver of environmental degradation and a major contributor to greenhouse gas emissions. But this appetite for destruction is coming back to bite us. Obesity is reaching epidemic levels, yet 800,000 people go to bed hungry. We face an emergency. The birth of agriculture 10,000 years ago was only possible because of the remarkable stability of Earth's life support system -- the interacting climate, soils, waterways, ice sheets, oceans, atmosphere and rich diversity of life. Our actions now put that stability at risk, and with it ...

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Multifocal extramammary Paget's disease-associated adenocarcinoma: a rare condition of flexoral skin of multiple sites.

Sun, 20 Mar 2016 01:46:01 +0100

We present a case of triple extramammary Paget disease of the groin and bilateral axillae in a diabetic patient whose axillary lesions appeared consistent with acanthosis nigricans. This case demonstrates the need to consider EMPD in the evaluation of acanthosis of the axilla given its ability to mimic more common conditions. PMID: 26990474 [PubMed - in process] (Source: Dermatol Online J)



Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: As biomarkers and targets for new treatments

Sun, 20 Mar 2016 00:00:00 +0100

Publication date: Available online 15 March 2016 Source:Mechanisms of Ageing and Development Author(s): Rosalinda Madonna, Giuseppina Novo, Carmela Rita Balistreri Preclinical and clinical studies suggest that specific subsets of cells isolated from the peripheral blood, play an essential role in the imbalance of damage and repair during age-associated diseases, such as metabolic syndrome, diabetes, atherosclerosis, neurodegenerative diseases, osteoporosis and cancer. Endogenous regeneration of the vessel wall involves cells of the vascular wall, inflammatory cells, circulating precursors, and mature endothelial cells, which are capable to restore the endothelium in a concerted interaction. Early detection of such imbalances with specific biomarkers may reduce age-associated diseases ...



Associations of dairy products and meat consumption with retinal vessel calibers in subjects at increased cardiovascular risk

Sun, 20 Mar 2016 00:00:00 +0100

Conclusions High consumption of low fat milk, yogurt and cheese and low consumption of red meat could be beneficial for retinal microvascular health. Prospective studies are needed to verify these findings. (Source: Nutrition, Metabolism and Cardiovascular Diseases)



National Prevalence, Causes, and Risk Factors for Bariatric Surgery Readmissions

Sun, 20 Mar 2016 00:00:00 +0100

Conclusions 30-day readmission following bariatric surgery is prevalent and closely associated with complications. (Source: The American Journal of Surgery)



5α-Dihydrotestosterone enhances wound healing in diabetic rats

Sun, 20 Mar 2016 00:00:00 +0100

Publication date: Available online 20 March 2016 Source:Life Sciences Author(s): Reggiani V. Gonçalves, Rômulo D. Novaes, Mariáurea M. Sarandy, Eduardo M. Damasceno, Sérgio L.P. da Matta, Neire M. de Gouveia, Mariella B. Freitas, Foued S. Espindola Wound healing involves a complex interaction between the cells, extracellular matrix and oxidative response. Aims Analyze the effects of 5α-Dihydrotestosterone (5α-DTH) ointment in cutaneous wound healing by secondary intention in diabetic Wistar rats. Main methods Rats (302.23±26.23g, n =48) were maintained in cages with food and water ad libitum in accordance with the Guiding Principles in the Use of Animal Ethics Committee. Diabetes was induced by intraperitoneal injection of streptozotocin (60mg/kg). Three skin wounds (12m...

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Early diabetic kidney maintains the corticomedullary urea and sodium gradient

Sun, 20 Mar 2016 00:00:00 +0100

This study demonstrates significant corticomedullary urea and sodium gradients in both control and diabetic rats using hyperpolarized MR in vivo, similarly to what previously has been described using invasive techniques. The results indicate that the early metabolic and hypertrophic changes occurring in the diabetic kidney prelude the later functional alterations in diabetic kidney function, thus driving the increased metabolic demand commonly occurring in the diabetic kidney. (Source: Physiological Reports)



Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion

Sun, 20 Mar 2016 00:00:00 +0100

Abstract Type 2 diabetes is associated with impaired nutrient‐regulated anaplerosis and insulin secretion in pancreatic β‐cells. One key anaplerotic substrate that may be involved in regulating insulin release is α‐ketoglutarate (αKG). Since prolyl hydroxylase domain proteins (PHDs) can metabolize cytosolic αKG, we sought to explore the role of this enzyme in the regulation of β‐cell function. The oxygen‐sensing PHDs regulate the stability of hypoxia‐inducible factor 1α (HIF1α) as well as other proline‐containing proteins by catalyzing the hydroxylation of proline residues. This reaction is dependent on sufficient levels of oxygen, iron, and αKG. In the present study, we utilized both pharmacological and genetic approaches to assess the impact of inhibiting PHD activi...



CTGF mediates high-glucose induced epithelial-mesenchymal transition through activation of β-catenin in podocytes.

Sat, 19 Mar 2016 21:48:03 +0100

Conclusion CTGF and β-catenin are involved in the EMT of podocytes in diabetes. CTGF mediates high-glucose induced EMT through activation of β-catenin in podocytes. CTGF inhibition may protect podocytes from EMT in diabetes. PMID: 26984259 [PubMed - as supplied by publisher] (Source: Renal Failure)



Retro-Mode Scanning Laser Ophthalmoscopy Planning for Navigated Macular Laser Photocoagulation in Macular Edema.

Sat, 19 Mar 2016 19:30:02 +0100

Conclusion. The RM-SLO image superimposed onto the fundus of the same eye can be used to guide MLP with narrow variability in treatment planning among retina specialists. The treatment areas suggested by RM-SLO-guided MLP plans for ME were shown to be larger than those suggested by OCT-guided plans. PMID: 26989498 [PubMed] (Source: Journal of Ophthalmology)



Subacute inhalation exposure to ozone induces systemic inflammation but not insulin resistance in a diabetic mouse model.

Sat, 19 Mar 2016 19:27:02 +0100

Authors: Ying Z, Allen K, Zhong J, Chen M, Williams KM, Wagner JG, Lewandowski R, Sun Q, Rajagopalan S, Harkema JR Abstract Epidemiological studies suggest that diabetics may be more susceptible to the adverse health effects from exposure to high ambient concentrations of ozone, the primary oxidant gas in photochemical smog. While increased morbidity and mortality from ozone inhalation has been linked to disruption of normal cardiovascular and airway functions, potential effects on glucose and insulin homeostasis are not understood. We tested the hypothesis that ozone exposure would worsen metabolic homeostasis in KKAy mice, a genetic diabetic animal model. Male KKAy mice were exposed to 0.5 ppm ozone for 13 consecutive weekdays, and then assessed for airway, adipose and systemic...

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Hypoglycaemia, diabetes therapies and driving categories in type 2 diabetes.

Sat, 19 Mar 2016 19:16:01 +0100

CONCLUSION: Hypoglycaemia risk is highest among drivers with poor diabetes self-management, those commuting or driving for a living and those taking insulin secretagogues. There is an educational need for all drivers concerning driving and hypoglycaemia. PMID: 26986544 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)



Prevalence and Co-prevalence of Comorbidities Among Patients With Type 2 Diabetes Mellitus.

Sat, 19 Mar 2016 19:16:01 +0100

Conclusions - The vast majority of patients with T2DM have multiple comorbidities. To ensure a comprehensive approach to patient management, the presence of multimorbidity should be considered in the context of clinical decision making. PMID: 26986190 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)



Home Cooking for Better Health?

Sat, 19 Mar 2016 18:19:13 +0100

I've been told my blood sugar is on the high side of normal and that I should lose some weight to avoid type 2 diabetes. I know I have to cut calories but wonder if you have any other advice. (Source: Dr. Weil Q and A)



Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines.

Sat, 19 Mar 2016 17:53:03 +0100

The objective of the present study was to investigate the anticancer activity of metformin in relation to ERα expression and its signaling pathway in ERα-positive MCF-7 and MDA-MB-361 breast cancer cells as well as TR MCF-7 breast cancer cells. Metformin inhibited both protein and mRNA levels of ERα in the presence or absence of estrogen (E2) in the MCF-7, TR MCF-7 and MDA-MB-361 cells. Metformin repressed E2-inducible estrogen response element (ERE) luciferase activity, protein levels and mRNA levels of E2/ERα-regulated genes [including c-Myc, cyclin D1, progesterone receptor (PR) and pS2] to a greater degree than tamoxifen, resulting in inhibition of cell proliferation of MCF-7, TR MCF-7 and MDA-MB-361 cells. Collectively, our results suggest that one of the anticancer mechanisms...



Activation of autophagy flux by metformin downregulates cellular FLICE-like inhibitory protein and enhances TRAIL- induced apoptosis.

Sat, 19 Mar 2016 17:51:03 +0100

In this study, we demonstrated that metformin could induce TRAIL-mediated apoptotic cell death in TRAIL-resistant human lung adenocarcinoma A549 cells. Pretreatment of metformindownregulation of c-FLIP and markedly enhanced TRAIL-induced tumor cell death by dose-dependent manner. Treatment with metformin resulted in slight increase in the accumulation of microtubule-associated protein light chain LC3-II and significantly decreased the p62 protein levels by dose-dependent manner indicated that metformin induced autophagy flux activation in the lung cancer cells. Inhibition of autophagy flux using a specific inhibitor and genetically modified ATG5 siRNA blocked the metformin-mediated enhancing effect of TRAIL. These data demonstrated that downregulation of c-FLIP by metformin enhanced TRAIL-...

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MicroRNA-335-5p inhibits osteoblast apoptosis induced by high glucose.

Sat, 19 Mar 2016 16:30:04 +0100

Authors: Li J, Feng Z, Chen L, Wang X, Deng H Abstract Diabetic osteoporosis represents a serious health condition with increasing incidence. Previous studies have shown that microRNA (miR)-335-5p is highly expressed in MC3T3-E1 osteoblasts and promotes their differentiation via downregulating the expression of dickkopf‑1 (DKK1). The present study investigated the effects of miR‑335‑5p on apoptosis of osteoblasts induced by high glucose (HG), as well as the underlying molecular mechanisms. MC3T3‑E1 osteoblasts were transfected with miR‑335‑5p mimics or control miR and cultured under HG conditions for seven days. Reverse‑transcription PCR and showed that, compared with the control group, the expression levels of miR‑335‑5p were significantly downregulated in the H...



Histopathological nerve and skeletal muscle changes in rats subjected to persistent insulin-induced hypoglycemia.

Sat, 19 Mar 2016 14:30:02 +0100

Authors: Jensen VF, Mølck AM, Heydenreich A, Jensen KJ, Bertelsen LO, Alifrangis L, Andersen L, Søeborg H, Chapman M, Lykkesfeldt J, Bøgh IB Abstract New insulin analogues with a longer duration of action and a flatter pharmacodynamic profile are developed to improve convenience and safety for diabetic patients. During the nonclinical development of such analogues, safety studies must be conducted in nondiabetic rats, which consequently are rendered chronically hypoglycemic. A rat comparator model using human insulin would be valuable, as it would enable differentiation between effects related to either persistent insulin-induced hypoglycemia (IIH) or a new analogue per se. Such a model could alleviate the need for an in-study-comparator and thereby reduce the number of animals ...



Effect of deoxycorticosterone acetate-salt-induced hypertension on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats.

Sat, 19 Mar 2016 14:30:02 +0100

Authors: Ozaki K, Hamano H, Matsuura T, Narama I Abstract The relationship between hypertension and diabetic peripheral neuropathy (DPN) has recently been reported in clinical research, but it remains unclear whether hypertension is a risk factor for DPN. To investigate the effects of hypertension on DPN, we analyzed morphological features of peripheral nerves in diabetic rats with hypertension. Male WBN/Kob rats were divided into 2 groups: alloxan-induced diabetic rats with deoxycorticosterone acetate-salt (DOCA-salt) treatment (ADN group) and nondiabetic rats with DOCA-salt treatment (DN group). Sciatic, tibial (motor) and sural (sensory) nerves were subjected to qualitative and quantitative histomorphological analysis. Systolic blood pressure in the two groups exhibited a higher...



Surveillance and monitoring of major chronic diseases in Brazil - National Health Survey, 2013

Sat, 19 Mar 2016 09:19:16 +0100

Conclusion: The improvement of health services is essential for an effective response to the double burden of illness in the middle- and low-income countries. (Source: Revista Brasileira de Epidemiologia)



Health care among adults with self-reported diabetes mellitus in Brazil, National Health Survey, 2013

Sat, 19 Mar 2016 09:19:16 +0100

Discussion: The care reported by patients with diabetes, which is essential to maintain their quality of life and prevent serious outcomes, seemed, in most cases, to be adequate. (Source: Revista Brasileira de Epidemiologia)

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Prevalence of chronic non-communicable diseases and association with self-rated health: National Health Survey, 2013

Sat, 19 Mar 2016 09:19:16 +0100

Conclusions: Because these diseases are associated with modifiable risk factors, the prevention with population focus is the best strategy to reduce the burden of these diseases. (Source: Revista Brasileira de Epidemiologia)



Recommendations and practice of healthy behaviors among patients with diagnosis and diabetes in Brazil: National Health Survey (PNS), 2013

Sat, 19 Mar 2016 09:19:16 +0100

Conclusion: Results evidenced that people with diagnosis of hypertension and diabetes give priority to not use (stop) harmful health behaviors than to adopt practices that will bring benefits to their health. It is necessary to promote not only the adverse effects of harmful habits, but also the benefits of healthy behaviors to aging well. (Source: Revista Brasileira de Epidemiologia)



Medical News Today: High-fat diet may put future generations at risk of disease

Sat, 19 Mar 2016 08:00:00 +0100

Eating a high-fat diet may put your children at risk of diabetes and obesity, says a study that indicates the tendency may be passed on through epigenetic mechanisms. (Source: Health News from Medical News Today)



Biomechanical risk factors for tripping during obstacle-crossing with the trailing limb in patients with type II diabetes mellitus - Hsu WC, Liu MW, Lu TW.

Sat, 19 Mar 2016 06:34:47 +0100

People with type II diabetes mellitus (DM) are at a high risk of falling especially during more challenging locomotor tasks such as obstacle-crossing. The current study aimed to identify the risk factors for tripping in these patients during trailing-limb ... (Source: SafetyLit)