Last Build Date: Tue, 22 Mar 2016 08:22:17 +0100
Fri, 18 Mar 2016 00:00:00 +0100(Source: British Journal of Dermatology)
Thu, 17 Mar 2016 00:00:00 +0100Conclusions: Halometasone is efficacious with a good safety profile in patients with OCD, and there is no significant difference in efficacy of the drug in allergic and irritant OCD. (Source: Indian Journal of Pharmacology)
Wed, 16 Mar 2016 12:07:55 +0100A new phosphodiesterase 4 inhibitor could be a much-needed alternative to topical steroids and calcineurin inhibitors for mild to moderate eczema, according to two phase 3 studies. Medscape Medical News (Source: Medscape Allergy Headlines)
Wed, 16 Mar 2016 00:00:00 +0100Conclusions Our study is the first to deliver evidence for a significant reduction in systemic exposure to PTD through improved glove use. Disposable gloves should never be reused. PTD biomonitoring is shown to be a practical tool to quantify recent dermal exposure to oxidative hair dye components. (Source: Occupational and Environmental Medicine)
Tue, 15 Mar 2016 00:00:00 +0100Publication date: Available online 14 March 2016 Source:Pediatria Polska Author(s): Kamil K. Hozyasz Phenylketonuria is one of the best-known examples of inherited metabolic diseases. It is widely considered as a triumph of western medicine. Untreated phenylketonuria manifests as mental retardation, epilepsy, light complexion, eczema, and a „mousy” odour. This review gives some insight into history of the use of the disease's name, which was probably coined by the biochemist J.H. Quastel and focuses on the contributions of the first medical investigators in the area of abnormal phenylalanine metabolism – I.A. Følling, L.S. Penrose as well as G.A. Jervis. The story of the first family with children diagnosed to have phenylketonuria is presented. (Source: Pediatria Polska)
Tue, 15 Mar 2016 00:00:00 +0100CONCLUSION: The mutation analysis is helpful for the diagnosis of WAS patients and also expanding the spectrum of WASP mutations for carrier detection and prenatal diagnosis. PMID: 26993433 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Sat, 12 Mar 2016 00:00:00 +0100ConclusionsIn this cohort of young children in Norway, we found no association between vitamin D levels and the presence or severity of AE.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Sat, 12 Mar 2016 00:00:00 +0100CONCLUSIONS: In this cohort of young children in Norway, we found no association between vitamin D levels and the presence or severity of AE. This article is protected by copyright. All rights reserved. PMID: 26972308 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Fri, 11 Mar 2016 10:16:00 +0100Researchers conclude less severe eczema infection can be treated with topical steroids and emollients (Source: Clinical Pharmacist)
Fri, 11 Mar 2016 00:00:00 +0100ConclusionHigh omega‐3 LCPUFA milk levels in mothers who received omega‐3 LCPUFA supplements were related to fewer allergies in their children.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Fri, 11 Mar 2016 00:00:00 +0100ConclusionThe severity of acute bronchiolitis in infants was associated with reduced QoL nine months later.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Thu, 10 Mar 2016 00:00:00 +0100Publication date: May 2016 Source:European Journal of Obstetrics & Gynecology and Reproductive Biology, Volume 200 Author(s): Vincent Lavoué, Xavier Fritel, Martine Antoine, Françoise Beltjens, Sofiane Bendifallah, Martine Boisserie-Lacroix, Loic Boulanger, Geoffroy Canlorbe, Sophie Catteau-Jonard, Nathalie Chabbert-Buffet, Foucauld Chamming's, Elisabeth Chéreau, Jocelyne Chopier, Charles Coutant, Julie Demetz, Nicolas Guilhen, Raffaele Fauvet, Olivier Kerdraon, Enora Laas, Guillaume Legendre, Carole Mathelin, Cédric Nadeau, Isabelle Thomassin Naggara, Charlotte Ngô, Lobna Ouldamer, Arash Rafii, Marie-Noelle Roedlich, Jérémy Seror, Jean-Yves Séror, Cyril Touboul, Catherine Uzan, Emile Daraï Screening with breast ultrasound in combination w...
Thu, 10 Mar 2016 00:00:00 +0100CONCLUSION: This study provides greater knowledge of dermatological diseases in prison and shows teledermatology to be a tool suited to the specific constraints of this universe, while providing inmates with medical care as close as possible to that of the general population, and it thus helps ensure that their fundamental human rights are upheld. PMID: 26971370 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Wed, 09 Mar 2016 18:55:38 +0100In May 2011, the U.S. Food and Drug Administration approved a request by Nestle to be able to market its 100 percent whey-protein partially hydrolyzed infant formula as reducing the risk of eczema. A new study, published in The BMJ that reviewed information from 37 different trials from 1946-2015, involving 19,000 participants, argues that may have been […] (Source: Washington Post: To Your Health)
Wed, 09 Mar 2016 05:00:00 +0100Updated Date: Mar 9, 2016 EST (Source: DailyMed Drug Label Updates)
Tue, 08 Mar 2016 14:00:21 +0100Follow me at @drClaire Want to prevent your child from being allergic to peanuts or eggs? Here’s what the latest research says you should do: Feed them peanut products and eggs when they are babies. I’ve been a pediatrician for more than 25 years, and the standard advice I gave families for years — advice recommended by allergy specialists — was to hold off on giving babies foods that commonly cause allergic reactions. I told them not to give egg, dairy, seafood, or wheat in their child’s first year — and to wait until 2 or 3 years old to give peanuts or other nut products. That was bad advice. A few years ago, research began to suggest that there was no particular benefit to waiting to give those foods. Children seemed to develop food allergies whether their parents waited...
Tue, 08 Mar 2016 13:29:02 +0100Authors: Ibáñez-Sanz G, Rodríguez Alonso L, Romero Martínez NM Abstract A 35-year-old man, with a history of rhinitis, eczema and a dubious achalasia was admitted due to chest pain and sialorrhea. Upper endoscopy showed a little hole and a narrowing of the distal esophagus. A CT-scan with oral contrast exposed a discontinuity of the lumen of the middle third of the esophagus and a dissection of submucosal space 16 cm long. The patient recovered after parenteral nutrition. After four months, an esophageal endoscopic showed transient whitish exudates, longitudinal furrows and esophageal lacerations. The biopsies illustrated significant eosinophilic inflammation, eosinophilic microabscesses and basal cell hyperplasia. PMID: 26949147 [PubMed - in process] (Source: Revista Espa...
Tue, 08 Mar 2016 05:00:00 +0100Updated Date: Mar 8, 2016 EST (Source: DailyMed Drug Label Updates)
Tue, 08 Mar 2016 00:00:00 +0100Publication date: March–April 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 4, Issue 2 Author(s): Matthew J. Greenhawt, David M. Fleischer, Dan Atkins, Edmond S. Chan Recommendations for the timing of introducing major food allergens, such as peanut, into the diet of at-risk infants have undergone major changes in the past decade. The most substantial modification has been a shift toward advice that delaying beyond 4 to 6 months does not prevent and might actually increase the risk of food allergy. The Learning Early About Peanut (LEAP) study published last year provided strong evidence that early peanut introduction with regular ingestion has a potentially dramatic benefit. Although there is little current doubt of the effectiveness of early peanu...
Tue, 08 Mar 2016 00:00:00 +0100Conclusions Children with both food allergy and eczema were shorter and lighter throughout early childhood, with more pronounced differences in those with persistent food allergy. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Mon, 07 Mar 2016 13:30:00 +0100Conclusion This was a follow-up study of a well-designed randomised controlled trial. The original study found the early introduction of regular small amounts of peanut protein to infants at high risk of having peanut allergy reduced the proportion that developed a peanut allergy by the age of five, compared with avoiding peanuts completely. The latest study found that even if the children who had been exposed to peanuts then avoided them for 12 months, this did not significantly increase their likelihood of developing a peanut allergy. Strengths of the study include the use of objective tests to determine how well the children managed to avoid peanuts, as well as a questionnaire. The group who avoided peanuts during the trial were better at avoiding them during follow-up, and this m...
Mon, 07 Mar 2016 00:00:00 +0100By Christine Judge and Kelly Young Edited by Susan Sadoughi, MD, and André Sofair, MD, MPH Early introduction of allergenic foods in infancy continues to show promise in reducing risk for developing food allergies, suggest two studies in the New England Journal of Medicine presented at the American Academy of Allergy, Asthma & Immunology's annual meeting.In the first study, children with severe eczema or egg allergy who were randomized to consume peanuts before … (Source: Physician's First Watch current issue)
Thu, 03 Mar 2016 20:31:09 +0100Let me tell you a story.... When I was living at home with my parents I never had to cook a single meal. In fact, my friends used to make jokes at me as I did not know how to turn on the stove (yes, this is how bad I was in the kitchen). I didn't do food shopping either. Mom did everything and I did not bother to learn... what a huge mistake. When I moved overseas I had to learn how to shop and feed myself. Was it easy? Nope! It was fun to buy whatever I wanted... but I made many mistakes. I used to spend a lot of money buying packaged foods, frozen meals, ice creams and sweets. It did not like veggies, and did not know how to cook an egg or a bowl of rice. I ended up putting on weight, getting bad eczema, suffering from constipation and throwing away money that wasn't easy to earn. It to...
Thu, 03 Mar 2016 01:05:52 +0100Authors: Francis NA, Ridd MJ, Thomas-Jones E, Shepherd V, Butler CC, Hood K, Huang C, Addison K, Longo M, Marwick C, Wootton M, Howe R, Roberts A, Inaam-ul Huq M, Madhok V, Sullivan F on behalf of the CREAM team. (Source: NIHR Journals Library)
Tue, 01 Mar 2016 15:40:02 +0100CONCLUSIONS: We propose the REACH as new full, questionnaire-based diagnostic criteria for childhood AD in epidemiological surveys. Further studies are warranted to validate the REACH in different populations or countries in the context of large-scale, epidemiological surveys. PMID: 26922933 [PubMed - as supplied by publisher] (Source: Allergy, Asthma and Immunology Research)
Tue, 01 Mar 2016 15:40:02 +0100Authors: Lee JH, Son SW, Cho SH Abstract Atopic eczema (AE) is a chronic, inflammatory skin disorder which usually develops in early childhood. In spite of intensive investigations, the causes of AE remain unclear, but are likely to be multifactorial in nature. Environmental factors or genetic-environmental interactions seem to play a key role in disease progression. Among various measures of AE managment, cutaneous hydration, which improves barrier function and relieve itchiness, may be helpful to reduce the need for topical steroid use and therefore should be used as a basic treatment. Avoiding aggravating factors is also a basic treatment of AE. Standard medical treatment with a pharmacologic approach may be necessary if basic treatment fails to control symptoms satisfactorily. ...
Tue, 01 Mar 2016 00:00:00 +0100Conclusion: The pattern of dermatoses seen among the Nicobarese is quite similar with respect to the prevalence of infections in other regions of India, especially humid regions such as Assam, coastal Karnataka, and Kolkata and much higher than arid regions such as the deserts of Rajasthan. (Source: Indian Journal of Dermatology)
Tue, 01 Mar 2016 00:00:00 +0100ConclusionsThis study demonstrates that DNA methylation in adulthood is associated with season of birth, supporting the hypothesis that DNA methylation could mechanistically underlie the effect of season of birth on allergy, though other mechanisms are also likely to be involved.This article is protected by copyright. All rights reserved. (Source: Allergy)
Mon, 29 Feb 2016 00:00:00 +0100Conclusions: Observed cutaneous AEs are likely related to the immunomodulatory effects DAC-HYP exerts on innate lymphoid cells, including natural killer cells. Vigilance and timely management of skin reactions may prevent treatment discontinuation in participants with severe rash. (Source: Neurology)
Fri, 26 Feb 2016 00:00:00 +0100Conclusion Timely diagnosis and inpatient care has important implications on appropriate treatment, duration of hospital stay and patient outcome. (Source: Irish Journal of Medical Science)
Thu, 25 Feb 2016 00:00:00 +0100Immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome is a rare disorder that increasingly has gained attention as a model of genetic autoimmunity. Numerous papers documenting the key clinical and molecular characteristics of IPEX have provided a detailed understanding of this devastating disease. IPEX is a primary immunodeficiency caused by mutations in the gene FOXP3, which encodes an essential transcription factor required for maintenance of thymus‐derived regulatory T (tTreg) cells. tTreg cell dysfunction is the main pathogenic event leading to multiorgan autoimmunity in IPEX. In addition to the traditional clinical presentation (i.e., severe enteropathy, type 1 diabetes, and eczema), IPEX may encompass other variable and distinct clinical manifestations....
Wed, 24 Feb 2016 05:00:00 +0100Updated Date: Feb 24, 2016 EST (Source: DailyMed Drug Label Updates)
Wed, 24 Feb 2016 00:00:00 +0100ConclusionThis report evaluates excimer laser for patients with refractory CHFE and shows excellent and sustained efficacy for this treatment. Compared to other UV therapies, excimer laser offers lower cumulative doses of UV radiation by targeting specific areas. This effective treatment should be considered alone or in combination with other established or newer therapies. (Source: International Journal of Dermatology)
Tue, 23 Feb 2016 23:35:59 +0100We describe 2 particular cases of periungual PG in which the clinical history has been fundamental. In the first case, there was an underlying hand eczema, and in the second case, a foreign body was present.Skin Appendage Disord 2015;1:175-178 (Source: Skin Appendage Disorders)
Tue, 23 Feb 2016 00:00:00 +0100ConclusionsIn a representative U.K. child cohort, eczema was more common in more advantaged children. This was explained partially by early‐life factors including not smoking during pregnancy, breastfeeding and having fewer siblings. (Source: British Journal of Dermatology)
Sat, 20 Feb 2016 00:00:00 +0100We present the case of a 39-year-old plumber who was diagnosed with infective endocarditis due to Staphylococcus aureus. The route of entry was attributed to the patient scratching pruritic lesions of his poorly controlled atopic dermatitis (eczema). We recommend that medical practitioners of patients with poorly controlled atopic dermatitis should pay particular attention to, and take measures to mitigate against, this risk.
Fri, 19 Feb 2016 10:35:23 +0100In 2009, mutations in the DOCK8 gene were identified as the cause of autosomal recessive Hyper-IgE syndrome, a combined immunodeficiency characterized by elevated IgE, respiratory infections, viral infections, eczema, severe food allergies and a high cancer risk. Cohort studies have shown that this disease has a dismal natural disease outcome with most patients dying prematurely, suggesting that early allogeneic HSCT should be the standard of care. A number of case reports have suggested that HSCT can cure all disease manifestations with the exception of food allergies, which can persist for years. (Source: Biology of Blood and Marrow Transplantation)
Fri, 19 Feb 2016 00:00:00 +0100This study examined the relationship between particulate matter (PM) exposures in preschool age children and major correlates of asthma, such as wheeze and eczema. Air sampling was carried out using a robotic (PIPER) child-sampling surrogate. This study enrolled 128 participants, 57 male and 71 female children. Ages ranged from 3 to 58 months with the mean age of 29.3 months. A comparison of subjects with and without eczema showed a difference in the natural log (ln) of PM collected from the PIPER air sampling (p = 0.049). PIPER’s sampling observed an association between the ln PM concentrations and eczema, but not an association with wheezing history in pre-school children. Our findings are consistent with the hypothesis of the role of the microenvironment in mediating atopic dermatitis...
Thu, 18 Feb 2016 05:00:00 +0100Updated Date: Feb 18, 2016 EST (Source: DailyMed Drug Label Updates)
Wed, 17 Feb 2016 17:44:02 +0100Authors: Plötz SG, Wiesender M, Todorova A, Ring J Abstract INTRODUCTION: Atopic eczema (AE) is a chronic relapsing inflammatory skin condition and one of the most common, potentially debilitating diseases with increasing incidence. AREAS COVERED: The complex etiology of AE with multiple systemic and local immunologic and inflammatory responses and interactions between susceptibility genes and environmental factors leading to defects in skin barrier function and eczematous skin lesions is presented. Knowledge of pathogenesis is important for understanding the more innovative treatment approaches discussed. EXPERT OPINION: Basic therapy consists of hydrating topical treatment and avoidance of specific and unspecific provocation factors. For acute eczematous skin lesions, an...
Wed, 17 Feb 2016 14:27:02 +0100Authors: West CE, Jenmalm MC, Kozyrskyj AL, Prescott SL Abstract Microbial ecosystems cover the surface of the human body and it is becoming increasingly clear that our modern environment has profound effects on microbial composition and diversity. A dysbiotic gut microbiota has been associated with allergic diseases and asthma in cross-sectional and observational studies. In an attempt to restore this dysbiosis, probiotics have been evaluated in randomized controlled trials. Here, we review treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context. Many meta-analyses have shown a moderate benefit of probiotics for eczema prevention, whereas there is less evidence of a benefit for other allergic m...
Wed, 17 Feb 2016 14:27:02 +0100Authors: Schwensen JF, Bregnbak D, Johansen JD Abstract Numerous studies have focused on emerging allergens causing contact allergy and allergic contact dermatitis in eczema populations and the general population, whereas only a few European multicenter studies systematically manage to detect prevalence rates of various contact allergies over time in eczema populations. Contact allergy is a life-time condition, which may lead to allergic contact dermatitis in individuals who do not manage to avoid exposure to the ascertained allergen in question. It is therefore of utmost importance that clinicians and dermatologists have sufficient knowledge on common allergens causing contact allergies in the general and working population. This review aimed to highlight the newest knowledge of f...
Wed, 17 Feb 2016 14:23:02 +0100Authors: D'Assante R, Fusco A, Palamaro L, Giardino G, Gallo V, Cirillo E, Pignata C Abstract Primary immunodeficiencies (PIDs) include a heterogeneous group of mostly monogenic diseases characterized by functional/developmental alterations of the immune system. Skin and skin annexa abnormalities may be a warning sign of immunodeficiency, since both epidermal and thymic epithelium have ectodermal origin. In this review, we will focus on the most common immune disorders associated with ectodermal alterations. Elevated IgE levels represent the immunological hallmark of hyper-IgE syndrome, characterized by severe eczema and susceptibility to infections. Ectodermal dysplasia (ED) is a group of rare disorders that affect tissues of ectodermal origin. Hypoidrotic ED (HED), the most commo...
Tue, 16 Feb 2016 16:42:40 +0100Follow me at @drClaire All pediatricians have certain “speeches” they can do in their sleep — like the safe sleep speech, the potty-training speech, the healthy diet speech, or the speeches for managing fever, common colds, or vomiting and diarrhea. But research over the past few years has changed one of those speeches: the speech about starting solid foods. I still say the same things about waiting until at least age 4 months to start (closer to 6 months is likely better, especially if baby is getting breast milk), and about not starting two new foods at a time (so as to know the culprit should baby get constipated or a rash). But now, there are three big changes to what I will say: Don’t give rice cereal. Rice cereal used to be my go-to starting food. It’s mild and babies usua...
Tue, 16 Feb 2016 03:23:09 +0100Authors: Djokic-Gallagher J, Rosher P, Walker J, Sykes K, Hart V Abstract OBJECTIVE: The aim of this study was to compare the moisturising efficacy and acceptability of physical characteristics of two commonly prescribed emollients licenced in the UK, Doublebase Dayleve gel (DELP) and Diprobase cream (DIPC). METHODS: The study was a double-blind, concurrent bi-lateral comparison in female eczema subjects with dry skin. RESULTS: In Part 1, comparing the area under the curve (AUC) change from baseline corneometer readings over 24 h following single applications of the emollients to the volar forearms of 34 subjects, the AUC for DELP was more than three times that seen for DIPC (p < 0.0001). In Part 2, comparing the same outcome measured over 5 days of twice daily appli...
Tue, 16 Feb 2016 03:23:09 +0100CONCLUSIONS: This is the first study evaluating and confirming the potential use of β-glucan-based cream as a supportive complementary therapy of atopic dermatitis. PMID: 26654776 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Tue, 16 Feb 2016 03:23:09 +0100CONCLUSIONS: This study demonstrated that a four-week, twice-weekly regime of diluted bleach baths is not more useful than water baths in reducing S. aureus colonization/infection and improving AD. A longer treatment period is needed to evaluate if the short treatment duration was the main cause for the discrepancy in outcome from other bleach-bath trials. The usage of a portable bath tub obviates the problems associated with unavailability of bathing facilities in some families. PMID: 26270469 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Tue, 16 Feb 2016 03:23:09 +0100CONCLUSIONS: The BMV dressing is well-tolerated and effective in the treatment of inflammatory dermatoses, improving both the objective signs of the disease as well as patients' quality of life. PMID: 25898980 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Tue, 16 Feb 2016 03:23:09 +0100CONCLUSIONS: The extent of CS fears is independent of CS acceptability, but correlates with patients' QoL. Desensitization of parental CS fears should be integral part of eczema education and therapeutics in order to improve therapeutic efficacy and patients' QoL. PMID: 25895012 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Sun, 14 Feb 2016 15:25:02 +0100Conclusions Anti-TNF-α therapy is frequently associated with newly onset skin reactions, most commonly in patients with Crohn's disease. Non-infectious skin manifestations can be treated topically and do not require cessation of anti-TNF-α therapy. PMID: 26728295 [PubMed - in process] (Source: Scandinavian Journal of Gastroenterology)
Sun, 14 Feb 2016 14:09:02 +0100Authors: Phuong C, Maibach HI Abstract INTRODUCTION: Dermatology is a relatively small field concerned with conditions of the hair, skin, nails and their related diseases; yet there is considerable active research and development within the field. Pharmaceutical companies seek more effective treatments through various therapeutic classes and delivery routes. However, 28 drugs have been discontinued for the treatment of dermatologic diseases in 2014. AREAS COVERED: Herein, the authors summarize the details about each discontinued drug in 2014. The dermatological conditions covered are: psoriasis, eczema, leg ulcers, wounds, allergies, acne, scleroderma, lupus erythematosus, urticaria, mastocytosis, epidermolysis bullosa, onychomycosis and one other unspecified disease. The autho...
Fri, 12 Feb 2016 00:00:00 +0100ConclusionsMultiple, usually unvalidated outcome measure instruments have been used in HS RCTs. Where validation evidence is available there are issues of low methodological quality or incomplete validity assessment and so no instruments can be fully recommended currently.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Fri, 12 Feb 2016 00:00:00 +0100CONCLUSIONS: Overall, the quality of the evidence was low. The low quality was mainly due to the differing results between studies, lack of blinding in some studies, and relatively few studies reporting participant-centred outcome measures. We found limited evidence that SIT may be an effective treatment for people with AE. The treatments used in these trials were not associated with an increased risk of local or systemic reactions. Future studies should use high quality allergen formulations with a proven track record in other allergic conditions and should include participant-reported outcome measures. PMID: 26871981 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Thu, 11 Feb 2016 00:00:00 +0100Authors of a new study have noted an inverse association between the risk of developing glioma and a history of allergies. The researchers drew data from the Glioma International Case Control Study, which contains detailed information about atopic disorders for 4533 cases and 4171 controls in 14 sites and five countries. They concluded that a history of respiratory allergies reduces the risk of developing glioma (meta-analysis odds ratio 0·72 [95% CI 0·58–0·90]), as does having asthma (OR 0·77 [0·64–0·93]) and eczema (OR 0·71 [0·56–0·89]), compared with patients without allergies. (Source: The Lancet Oncology)
Wed, 10 Feb 2016 22:04:02 +0100Authors: Fölster-Holst R Abstract Eczematous disorders in adolescence (definition WHO: the period between 10 and 20 years) are common and include mainly atopic dermatitis, contact eczema, and seborrheic dermatitis. They all share the similarity of inflammatory reactions which mainly affect the epidermis and can take a chronic course, depending on the underlying dermatosis. In the following article, the particularities of eczematous diseases in adolescents are discussed. PMID: 26857132 [PubMed - as supplied by publisher] (Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete)
Tue, 09 Feb 2016 00:00:00 +0100ConclusionThis study suggests that the order of application of emollient and TCS does not matter in the treatment of AE in children and that parents can apply topical medications in whichever order they prefer. (Source: Pediatric Dermatology)
Tue, 09 Feb 2016 00:00:00 +0100This study is a systematic review of the measurement properties of patient-reported measures of QoL developed and/or validated for infants, children, and adolescents with eczema. A systematic literature search will be carried out in MEDLINE via PubMed and EMBASE using a selection of relevant search terms. Eligible studies will be primary empirical studies evaluating, describing, or comparing measurement properties of QoL instruments for infants, children, and adolescents with eczema. Two reviewers will independently perform eligibility assessment and data abstraction. Evidence tables will be used to record study characteristics, instrument characteristics, measurement properties, and interpretability. The adequacy of the measurement properties will be assessed using predefined criteria. Th...
Sat, 06 Feb 2016 07:46:00 +0100STAPH infections are commonly spoken about, but what do you really know about staphylococcus aureus? (Source: Daily Express - Health)
Sat, 06 Feb 2016 00:00:00 +0100Researchers found 30 percent lower odds for those with respiratory allergies and eczema (Source: Cancercompass News: Other Cancer)
Fri, 05 Feb 2016 18:16:38 +0100Researchers found 30 percent lower odds for those with respiratory allergies and eczema (Source: WebMD Health)
Fri, 05 Feb 2016 18:00:00 +0100Researchers found 30 percent lower odds for those with respiratory allergies and eczema (Source: The Doctors Lounge - Oncology)
Fri, 05 Feb 2016 16:07:03 +0100Authors: Weisshaar E Abstract One third of all occupation-related diseases are diseases of the skin, and in most of these cases the skin barrier is involved. Professions such as metalworkers, hairdressers, and health care and construction workers are mainly affected. Among them, contact dermatitis is the leading skin disease. It usually presents as hand eczema caused by or leading to impaired barrier function. All this significantly impacts the function of the hands, reduces the ability to work and especially impairs the patient's quality of life. Diagnostics and therapy are of great importance; in addition, prevention programs are meanwhile an important mainstay of the overall therapeutic concept. They comprise measures of secondary (outpatient) and tertiary (inpatient) prevention...
Fri, 05 Feb 2016 11:46:00 +0100STAPH infections are commonly spoken about, but what do you really know about staphylococcus aureus? (Source: Daily Express - Health)
Thu, 04 Feb 2016 00:00:00 +0100ConclusionsPollutants in conjunction with climate factors may differentially impact eczema prevalence and severity, some with apparent harmful effects.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Thu, 04 Feb 2016 00:00:00 +0100Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention. Cancer Epidemiol Biomarkers Prev; 25(2); 282–90. ©2016 AACR. (Source: Cancer Epidemiology Biomarkers and Prevention)
Wed, 03 Feb 2016 00:00:00 +0100(Source: Allergy)
Wed, 03 Feb 2016 00:00:00 +0100Conclusions The results show that oral alitretinoin is being used according to established recommendations and that response is good, with few adverse effects. The dermatologists agreed that the benefits favored adherence and improved the patients’ health related quality of life. (Source: Actas Dermo-Sifiliograficas)
Wed, 03 Feb 2016 00:00:00 +0100This article discusses the evidencebased management of atopic eczema in children. (Source: Prescriber)
Tue, 02 Feb 2016 00:00:00 +0100We present practical guidelines for differentiating among these various entities, with the aim of helping physicians decide what type of genetic test should be carried out –and when– in order to establish a definitive diagnosis. (Source: Actas Dermo-Sifiliograficas)
Tue, 02 Feb 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. PMID: 26833102 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Tue, 02 Feb 2016 00:00:00 +0100ConclusionPerinatal indoor aeroallergen exposure does not seem to affect development of allergic sensitization or rhinitis during childhood questioning the relevance of allergen avoidance as a preventive measure. Other factors such as timing of allergen exposure or other environmental adjuvants may contribute in a more complex pathway to sensitization.This article is protected by copyright. All rights reserved. (Source: Allergy)
Tue, 02 Feb 2016 00:00:00 +0100Authors: Peacock S PMID: 26844601 [PubMed - in process] (Source: British Journal of Community Nursing)
Tue, 02 Feb 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Mon, 01 Feb 2016 06:00:00 +0100Abstract: Probiotics are live nonpathogenic microorganisms. Many of these microorganisms are part of the normal human gut flora, where they live in a symbiotic relationship. Probiotics have been used to treat gastrointestinal (GI) and non-GI medical conditions. However, the data supporting their use are often conflicting, especially for non-GI-associated illnesses. The strongest evidence supporting the use of probiotics is related to the treatment of acute diarrhea and pouchitis. Atopic eczema in children and genitourinary infections are the only non-GI-related medical conditions where probiotics may have some beneficial effects. Product selection and dosing are not the same in all conditions, and the beneficial effects of each probiotic strain cannot be generalized. The purpose of this a...
Mon, 01 Feb 2016 00:00:00 +0100Many women report skin issues due to the hormonal influences of pregnancy. These common dermatologic discomforts include changes in nails, skin, and vascularity (spider veins); hyperpigmentation (melasma); and, most commonly, stretch marks (striae gravidarum). Mild pruritus (pruritus gravidarum) may be found in approximately 17% of pregnancies, with eczema being the most frequently occurring disorder.1 However, only a small number will actually require referral and treatment. Pruritus can often be misinterpreted as related only to a change in detergent, perfumes, or use of other products that come into contact with the skin, but the primary care nurse practitioner (NP) should be prepared to recognize, diagnose, and treat specific dermatoses of pregnancy, including herpes gestationis/pemph...
Mon, 01 Feb 2016 00:00:00 +0100ConclusionThis study confirms a history of AD as the strongest predictor of persistent hand eczema. We additionally found, that a history of AD was associated with incident hand eczema in adults in contrast to FLG mutations which were only associated with persist hand eczema in atopic individuals, and not with incident hand eczema. Our study adds new knowledge to the interplay between AD, FLG mutations and hand eczema in the adult general population.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Sat, 30 Jan 2016 10:31:04 +0100ConclusionsThe website users benefited from the website, although this was not substantiated by clinical measurements. The trial design partly hampered website utilization. An initial feasibility study could have been warranted. (Source: Contact Dermatitis)
Sat, 30 Jan 2016 10:15:04 +0100CONCLUSION: Self-medication use is most prevalent. Most patients had reported dissatisfaction from the use of self-medications. Adverse reactions resulting from self-medication were also found. PMID: 26817222 [PubMed - in process] (Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet)
Fri, 29 Jan 2016 00:00:00 +0100Eczema vaccinatum (EV) is a life-threatening complication of exposure to smallpox vaccination in patients with atopic dermatitis (AD) characterized by dissemination of vaccinia virus (VV) in the skin and internal organs.1 We have shown that BALB/c mice inoculated with VV at sites of allergic skin inflammation elicited by epicutaneous sensitization with ovalbumin (OVA) exhibit features of EV.2 They include satellite lesions and VV dissemination to internal organs. EV features were absent in mice inoculated with VV in control skin epicutaneously sensitized with saline, suggesting that allergic skin inflammation predisposes to VV dissemination,2 which is consistent with the known role of the TH2 cytokine IL-4 in promoting VV dissemination. (Source: Journal of Allergy and Clinical Immunology...
Fri, 29 Jan 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Fri, 29 Jan 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. PMID: 26822010 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Thu, 28 Jan 2016 13:34:28 +0100ConclusionpHF‐OS does not prevent eczema in the first year in high risk infants. The immunological changes found require confirmation in a separate cohort.This article is protected by copyright. All rights reserved. (Source: Allergy)
Thu, 28 Jan 2016 00:00:00 +0100Abstract Discoveries in the defective molecular composition of the epidermal barrier, such as the epidermal protein filaggrin, in those with atopic eczema (or atopic dermatitis [AD]) have proved crucial in understanding this disease, but its aetiology remains to be fully elucidated. The epidermal barrier is just one interface between the microbial world and our immune system. Recent advances in molecular technology have demonstrated for the first time the true scale of the normal human microbiome and changes seen in disease states. In this review article we discuss the role of the human microbiome in the aetiology and maintenance of AD. The role of Staphylococcus aureus within the skin microbiome is examined, in addition to the role of other bacteria and fungi, identified using novel cultu...
Thu, 28 Jan 2016 00:00:00 +0100Authors: Thomas CL, Fernández-Peãns P Abstract Discoveries in the defective molecular composition of the epidermal barrier, such as the epidermal protein filaggrin, in those with atopic eczema (or atopic dermatitis [AD]) have proved crucial in understanding this disease, but its aetiology remains to be fully elucidated. The epidermal barrier is just one interface between the microbial world and our immune system. Recent advances in molecular technology have demonstrated for the first time the true scale of the normal human microbiome and changes seen in disease states. In this review article we discuss the role of the human microbiome in the aetiology and maintenance of AD. The role of Staphylococcus aureus within the skin microbiome is examined, in addition to the role of other ...
Thu, 28 Jan 2016 00:00:00 +0100This article reviews selected diets for a few common pediatric disorders including eczema, attention deficit hyperactivity disorder, headache and migraine, non-celiac gluten sensitivity, and irritable bowel syndrome. (Source: Current Problems in Pediatric and Adolescent Health Care)
Tue, 26 Jan 2016 11:00:24 +0100Photo Courtesy of Simon & Schuster Maya Shetreat-Klein, MD is an integrative pediatric neurologist. Her new book, The Dirt Cure is published by Atria Publishing Group, a sister company of CBS. She lectures internationally to medical professionals and laypeople on environmental health and toxins, and healing with food and nature. Many children in my practice improve tremendously from any number of conditions—asthma, eczema, constipation, headaches, ADHD, seizures—when we remove foods that bother their bodies. Unfortunately, traditional allergy tests don’t always tell the whole story of food reactivity. The best way to determine whether a food contributes to your child’s symptoms—whether allergy, sensitivity, or otherwise—is to eliminate it from his or her diet for a month an...
Tue, 26 Jan 2016 02:31:03 +0100ConclusionsSSO is a rare cause of contact allergy, with a 5‐year prevalence of 0.2% in consecutively tested patients. Contact allergy to the emulsifier does not play a major role when the overall frequency of contact allergy to FM I is evaluated. However, to correctly diagnose individual patients, concomitant patch testing with FM I and SSO is encouraged. (Source: Contact Dermatitis)
Tue, 26 Jan 2016 00:00:00 +0100Conclusions Just under half the infants with confirmed food hypersensitivity had no demonstrable IgE. In an exploratory analysis, risk factors for this phenotype of food hypersensitivity differed from those for IgE-mediated food allergy except for a healthy infant diet which was associated with less risk for both phenotypes. (Source: Clinical and Translational Allergy)
Mon, 25 Jan 2016 20:40:00 +0100Postinflammatory hyperpigmentation (PIH) develops as darkly pigmented macules that occur after an inflammatory process of the skin such as acne, folliculitis, eczema, or shaving irritation. Patients... (Source: Cutis: Cutaneous Medicine for the Practitioner)
Mon, 25 Jan 2016 00:00:00 +0100Anaphyllumwightii. Schott is a very rare and endemic threatened plant belonging to the family Areacea. It has been used in the tribal medicine to treat eczema, scabies and as antidote against snakebite.Different solvent extracts of Anaphyllumwightii.Schott were prepared and analysed for phytochemical screening by standard protocols. Antimicrobialactivity was measured using well diffusion method and micro dilution broth method against clinical isolates. The n-butanol and methanol extracts of A. wightii showedsignificant activity against all of the selected microorganisms. Water extract did not show any activity against any of the organisms except Klebsiella sp.The MIC value for leaf n- butanol and methanol were 1.5 mg/ml to 2.5mg/ml and the MBC values were 1.25 to 5 5mg/ml respectively.Th...
Sun, 24 Jan 2016 15:06:21 +0100Have you ever wondered how you manage to get through a particularly stressful period – whether it's an intense deadline at work, final exams in school or a spate of holiday houseguests – only to get sick after the stress has lifted? It's not a fluke. It's a phenomenon that's often referred to as "the let-down effect," a pattern in which people come down with an illness or develop flare-ups of a chronic condition not during a concentrated period of stress but after it dissipates, explains psychologist Marc Schoen, an assistant clinical professor of medicine at the University of California–Los Angeles and the author of "When Relaxation Is Hazardous to Your Health." Research has linked the let-down of perceived stress with an increase ...
Sat, 23 Jan 2016 12:29:02 +0100Authors: Pacheco-Gonzalez RM, Mallol J, Solé D, Brand PL, Perez-Fernandez V, Sanchez-Solis M, Garcia-Marcos L, EISL Study Group Abstract Male gender, asthmatic heredity, perinatal tobacco smoke exposure and respiratory infections have been associated with wheeze in the first years of life, among other risk factors. However, information about what factors modify the time to the first episode of wheeze in infants is lacking. The present study analyses which factors are associated with shorter time to the first episode of wheeze in infants. Parents of 11- to 24-month-old children were surveyed when attending their health-care centres for a control visit. They answered a questionnaire including the age in months when a first wheeze episode (if any) had occurred (outcome variable). The...
Fri, 22 Jan 2016 00:00:00 +0100ConclusionsAlthough the results were unexpected based on previous studies of alitretinoin in the treatment of PPP, this study provided no evidence to support further exploration of alitretinoin in the treatment of severe PPP.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Fri, 22 Jan 2016 00:00:00 +0100ABSTRACT Cyclosporine (CS) is widely used in patients with refractory atopic dermatitis (AD). During CS treatment, many patients have a tendency to decrease their adherence to topical agents as their disease improves. Our aim was to compare the efficacy and relapse rate of CS treatment combined with topical therapy and CS monotherapy. This prospective, randomized, 6 month study involved 60 patients with moderate‐to‐severe AD who were randomly assigned to two groups, one receiving CS and topical agents and the other, CS only. Clinical outcomes were based on investigators’ global assessment (IGA) scores, eczema areas and severity index scores, and trans‐epidermal water loss. If a patient achieved treatment success (IGA score ≤2) during the study period, CS was stopped. Relapse rate...
Fri, 22 Jan 2016 00:00:00 +0100CONCLUSIONS: Although the results were unexpected based on previous studies of alitretinoin in the treatment of PPP, this study provided no evidence to support further exploration of alitretinoin in the treatment of severe PPP. This article is protected by copyright. All rights reserved. PMID: 26800106 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Thu, 21 Jan 2016 00:00:00 +0100ConclusionOur results suggest that levels of 25‐hydroxyvitamin D in mid‐gestation and at birth are not associated with the risk of overall eczema, eczema per year, or eczema patterns among children until the age of 4 years. (Source: Pediatric Allergy and Immunology)
Wed, 20 Jan 2016 05:26:03 +0100CONCLUSION: Our study confirms the necessity of CAS in the management of AD. In particular, NS sensitization should be considered for children with severe AD or larger extent of eczema and trunk involvement. PMID: 26775372 [PubMed - in process] (Source: Turkish Journal of Medical Sciences)
Wed, 20 Jan 2016 03:00:23 +0100Conclusions: The prevalence of some comorbidities was higher in MS patients and associated with greater disability and relapse risk. Treatment of these comorbidities in patients with MS has the potential to improve disease course and help in the understanding of the prognosis and outcomes of MS.Neuroepidemiology 2016;46:106-113 (Source: Neuroepidemiology)
Wed, 20 Jan 2016 00:00:00 +0100A 48-year-old man presented to his primary care physician with dyspnea on exertion. He did not have fever, chills, or night sweats, and his weight was stable. He reported no chest pain or pressure, orthopnea, paroxysmal nocturnal dyspnea, lower extremity swelling, or cough. His family history was notable for lung disease in his father. The patient had a 20-pack-year smoking history (having quit several years previously) but no other exposures. He had no history of asthma, allergies, or eczema. Physical examination revealed normal vital signs, normal jugular venous pressure, distant heart sounds, and an increased anterior-to-posterior chest diameter with increased duration of expiration. (Source: Mayo Clinic Proceedings)
Wed, 20 Jan 2016 00:00:00 +0100In conclusion, the long experience with topical pine tar therapy and its worldwide usage, together with the evidence presented in this review, suggests that pine tar is an effective treatment with minimal safety risk. PMID: 26790564 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)