Last Build Date: Tue, 22 Mar 2016 08:30:50 +0100
Mon, 21 Mar 2016 00:00:00 +0100Abstract Atopic dermatitis (AD) and acne vulgaris are among the most‐prevalent skin diseases in children. Both have been well documented in the literature to have significant negative effects on quality of life. Herein, we discuss the results of a comprehensive literature review aimed at assessing the impact of acne and AD on self‐esteem and identity. We highlight clinical tools for their assessment and offer coping strategies for patients and families. Multiple factors including relationships with parents and classmates, sports participation, and the sex of the patient contribute to the development of self‐esteem and identity in individuals with AD and acne. Atopic dermatitis was found to have significant behavioral effects on children, ultimately resulting in a lack of opportunity ...
Mon, 21 Mar 2016 00:00:00 +0100ConclusionOur findings suggest that cheilitis is quite common among acne vulgaris patients even before treatment with isotretinoin. (Source: Australasian Journal of Dermatology)
Sun, 20 Mar 2016 00:00:00 +0100Linked Article: Xiao et al. Br J Dermatol 2016; 174:522–532. (Source: British Journal of Dermatology)
Sat, 19 Mar 2016 21:41:02 +0100Authors: Marcinkiewicz M, Majewski S Abstract Antimicrobial peptides (AMPs) are effector molecules of the innate immune system of the skin. They present an activity against a broad spectrum of Gram-positive and Gram-negative bacteria as well as some fungi, parasites and enveloped viruses. Several inflammatory skin diseases including psoriasis, atopic dermatitis, acne vulgaris and rosacea are characterized by a dysregulated expression of AMPs. Antimicrobial peptides are excessively produced in lesional psoriatic scales or rosacea in contrast to the atopic skin that shows lower AMP levels when compared with psoriasis. The importance of the AMPs contribution to host immunity is indisputable as alterations in the antimicrobial peptide expression have been associated with various pathol...
Sat, 19 Mar 2016 00:00:00 +0100This article provides an overview of acne, rosacea, melasma, vitiligo, alopecia, nonmelanoma, and melanoma skin cancer, dermatitis, and lichen sclerosus. (Source: Obstetrics and Gynecology Clinics)
Fri, 18 Mar 2016 05:19:08 +0100(NaturalNews) There a many, many benefits to using nature as your dermatologist. As explained in a post at Love-Yourself-Naturally.com, the chemicals found in mass-produced skincare products can actually exacerbate, if not cause, skin problems. Your skin is very sensitive and can... (Source: NaturalNews.com)
Fri, 18 Mar 2016 00:00:00 +0100This article provides an overview of acne, rosacea, melasma, vitiligo, alopecia, nonmelanoma, and melanoma skin cancer, dermatitis, and lichen sclerosus. (Source: Obstetrics and Gynecology Clinics of North America)
Fri, 18 Mar 2016 00:00:00 +0100The objective was to study the effect of PDT in truncal acne vulgaris using liposomal methylene blue (LMB) versus IPL alone. Thirty-five patients with varying degrees of acne were treated with topical 0.1 % LMB hydrogel applied on the randomly selected one side of the back, and after 60 min the entire back was exposed to IPL. The procedure was done once weekly for three sessions and patients were re-evaluated 1 month after the third session by two independent dermatologists. Acne severity was graded using the Burton scale. Patient satisfaction using Cardiff Acne Disability Index (CADI) was recorded before and after treatment. On LMB-pretreated side, inflammatory acne lesion counts were significantly decreased by 56.40 % compared with 34.06 % on IPL alone. Marked improvement was seen o...
Tue, 15 Mar 2016 18:36:31 +0100By most measures, the United States' business-friendly environment has proven to be fertile for medical innovation. Compared to other countries, America has filed the most patents in the life sciences, is conducting most of the world's clinical trials and has published the most biomedical research. That's what makes the medical prominence of Cuba all the more surprising to those who view a free market as an essential driver of scientific discovery. Cuba is very poor, and yet the country has some of the healthiest, most long-lived residents in the world -- as well as a medical invention or two that could run circles around U.S. therapies, thanks to government investment in scientific research and a preventive public health approach that views medical care as a birthright. The isla...
Tue, 15 Mar 2016 14:49:32 +0100Dr Graeme Lipper reviews the results of a new meta-analysis. Medscape Dermatology (Source: Medscape Dermatology Headlines)
Tue, 15 Mar 2016 00:00:00 +0100Publication date: Available online 15 March 2016 Source:Journal of American Association for Pediatric Ophthalmology and Strabismus Author(s): Tiffany N.S. Ballard, César A. Briceño A 20-year-old woman underwent lacrimal gland biopsy for unilateral swelling and was unexpectedly found to have olive-green discoloration of her orbital rim. Postoperative questioning revealed that as a teenager she had been treated for acne with minocycline, a semisynthetic tetracycline antibiotic and a first-line treatment for moderate and severe acne. While hyperpigmentation is a known side effect of minocycline, reports of pigmentation changes of the periorbital bones are relatively rare and could pose a diagnostic dilemma during surgery. (Source: Journal of American Association for Pediatric Ophthalmol...
Mon, 14 Mar 2016 05:00:00 +0100Updated Date: Mar 14, 2016 EST (Source: DailyMed Drug Label Updates)
Mon, 14 Mar 2016 00:00:00 +0100Conclusions Contrary to original expectations, long-term antibiotic use in healthy adolescents with acne was not associated with weight gain. This finding, which was consistent across all analyses, does not support a weight-promoting effect of antibiotics in adolescents. (Source: Journal of Antimicrobial Chemotherapy)
Sat, 12 Mar 2016 00:00:00 +0100(Source: JDDG)
Fri, 11 Mar 2016 09:33:09 +0100As a go-to for relieving coughs and colds, Vicks VapoRub has far more uses than cold and flu relief. From acne treatment to insect repellent, FEMAIL rounds up some of the very best. (Source: the Mail online | Health)
Fri, 11 Mar 2016 05:00:00 +0100Updated Date: Mar 11, 2016 EST (Source: DailyMed Drug Label Updates)
Fri, 11 Mar 2016 05:00:00 +0100Updated Date: Mar 11, 2016 EST (Source: DailyMed Drug Label Updates)
Fri, 11 Mar 2016 00:00:00 +0100Abstract Retinoids are a group of substances comprising vitamin A and its natural and synthetic derivatives. Retinoids were first used in dermatology in 1943 by Straumfjord for acne vulgaris. Since that time, retinoids have been utilized in the management and treatment of various skin conditions, including photoaging. Photodamage of the skin occurs as a consequence of cumulative exposure to solar ultraviolet radiation (UVR) and is characterized by deep wrinkles, easy bruising, inelasticity, mottled pigmentation, roughness, and telangiectasias. The mechanism of UVR-induced photodamage is multifactorial. Retinoids have demonstrated efficacy in the treatment of photoaged skin. Indeed, understanding the pathophysiology of photoaging and the molecular mechanism of retinoids can not onl...
Fri, 11 Mar 2016 00:00:00 +0100CONCLUSIONS: Demodex mite density was markedly increased in both ETR and PPR patients. It is believed that the presence of demodex mites plays an important role in rosacea aetiopathogenesis. Demodex mite treatment may reduce the severity of the disease and slow its progressive nature. PMID: 26969834 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Thu, 10 Mar 2016 23:34:10 +0100We present 2 cases of SAPHO syndrome with MRI, bone scintigraphy, and FDG PET/CT findings. In case 1 with early-stage disease, the active osteitis showed osteolytic bone destruction with increased FDG uptake. In case 2 with late-stage disease, the inactive bone lesions presented as osteosclerosis with normal FDG uptake. Familiarity with the FDG PET/CT findings of SAPHO syndrome in different stages may be helpful for correct diagnosis. (Source: Clinical Nuclear Medicine)
Thu, 10 Mar 2016 05:00:00 +0100Updated Date: Mar 10, 2016 EST (Source: DailyMed Drug Label Updates)
Thu, 10 Mar 2016 00:00:00 +0100CONCLUSION: This study provides greater knowledge of dermatological diseases in prison and shows teledermatology to be a tool suited to the specific constraints of this universe, while providing inmates with medical care as close as possible to that of the general population, and it thus helps ensure that their fundamental human rights are upheld. PMID: 26971370 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Wed, 09 Mar 2016 05:00:00 +0100Updated Date: Mar 9, 2016 EST (Source: DailyMed Drug Label Updates)
Tue, 08 Mar 2016 19:43:01 +0100Authors: Leyden J Abstract The central role of inflammation in acne is now more clearly understood. Adapalene, a third-generation topical retinoid, down-regulates toll-like receptor 2 expression and inhibits activator protein-1 activity. In a fixed-dose combination, adapalene and benzoyl peroxide (BPO) act synergistically on inflammatory patterns through regulation of innate immunity. In addition to reducing inflammatory and non-inflammatory lesions, adapalene/BPO helps prevent lesion and microcomedone formation. The combination of a topical retinoid and antimicrobial agent remains the preferred approach for almost all patients with acne. In cases of more severe disease, there is a clinical benefit in combining adapalene/BPO with an oral antibiotic for 12 weeks. Most recently, adap...
Tue, 08 Mar 2016 19:43:01 +0100Authors: Leyden J Abstract A supplement article recently published in the Journal of the European Academy of Dermatology and Venereology by Dréno et al., members of the Global Alliance to Improve Outcomes in Acne group, summarized the data for the emerging concept that inflammation in general and the innate immune system specifically play a central role in the pathogenesis of acne. This review, entitled "Understanding innate immunity and inflammation in acne: implications for management", also discusses the impact of different treatment options on the innate immune response and inflammation. The aim of the present summary is to provide a synopsis of the key points made in the paper, from the members of the Global Alliance, as relevant to the main article within this supplement: "...
Tue, 08 Mar 2016 00:00:00 +0100This issue exemplifies the types of articles that JABFM publishes to advance family medicine. We have articles on the implications of health system organizational structures. Three of these are international articles at the level of the national health system (1 from China) and systematic local health interventions (1 from Canada and 1 from Netherlands). Inside the United States, where there are more family physicians, there is less obesity, and designation as a Patient Centered Medical Home is related to increased rates of colorectal cancer screening. Review articles on common clinical topics discuss treatments that are changing (acne in pregnancy) or lack consensus (distal radial fractures). We have articles on making life easier in the office, such as for predicting Vitamin D levels, os...
Tue, 08 Mar 2016 00:00:00 +0100We describe the safety profile of common therapies and outline approaches based on available evidence. Topical azelaic acid or benzoyl peroxide can be recommended as baseline therapy. A combination of topical erythromycin or clindamycin with benzoyl peroxide is recommended for inflammatory acne. Oral erythromycin or cephalexin is generally considered safe for moderate to severe inflammatory acne when used for a few weeks. A short course of oral prednisolone may be useful for treating fulminant nodular cystic acne after the first trimester. In general, topical and oral antibiotics should not be used as monotherapy, but combined with topical benzoyl peroxide to decrease bacterial resistance. Oral retinoids are teratogenic and absolutely contraindicated for women who are pregnant or consideri...
Mon, 07 Mar 2016 16:00:00 +0100If primary care physicians initiated therapy in patients with mild to moderate acne, they could significantly decrease referrals to dermatologists, reduce patient waiting times, and cut health care costs, based on a study published online March 6 in JAMA Dermatology. The researchers used... (Source: Skin and Allergy News)
Mon, 07 Mar 2016 07:00:00 +0100Title: Misconceptions About Acne Still CommonCategory: Health NewsCreated: 3/4/2016 12:00:00 AMLast Editorial Review: 3/7/2016 12:00:00 AM (Source: MedicineNet Skin General)
Mon, 07 Mar 2016 05:00:00 +0100Updated Date: Mar 7, 2016 EST (Source: DailyMed Drug Label Updates)
Mon, 07 Mar 2016 05:00:00 +0100Updated Date: Mar 7, 2016 EST (Source: DailyMed Drug Label Updates)
Mon, 07 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Mon, 07 Mar 2016 00:00:00 +0100This review of 253 referrals from primary care clinicians to dermatologists for acne measures algorithm-based treatment for the elimination of unnecessary dermatology appointments. (Source: JAMA Dermatology)
Mon, 07 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. PMID: 26949158 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Sun, 06 Mar 2016 17:44:17 +0100WASHINGTON – Acne patients are telling the truth when they describe feeling isolated, rejected, and stigmatized – and now there are data to prove it. Dr. Alexa B. Kimball, professor of dermatology... (Source: Family Practice News)
Sat, 05 Mar 2016 14:43:43 +0100WASHINGTON – Monotherapy is not recommended in treating moderate-severe acne, and antibiotics should always be coupled with topical therapy, according to the latest guidelines from the American Academy of Dermatology. And although it may be hard – even nearly impossible – to discontinue... (Source: Skin and Allergy News)
Sat, 05 Mar 2016 00:00:00 +0100Conclusions Results of this clinical trial demonstrate the significantly greater efficacy of adapalene 0.3 % A/BPO topical gel compared with vehicle as well as a good safety profile in the treatment of moderate to severe inflammatory non-nodulocystic acne, which increases patients’ treatment options. Clinicaltrials.gov identifier NCT01880320. (Source: American Journal of Clinical Dermatology)
Fri, 04 Mar 2016 18:18:17 +0100Skin condition isn't caused by poor hygiene or diet, dermatologist says (Source: WebMD Health)
Fri, 04 Mar 2016 17:00:00 +0100Skin condition isn't caused by poor hygiene or diet, dermatologist says Source: HealthDay Related MedlinePlus Page: Acne (Source: MedlinePlus Health News)
Fri, 04 Mar 2016 12:03:13 +0100FRIDAY, March 4, 2016 -- There are still plenty of negative and mistaken beliefs about people with acne, a new study finds. Researchers showed photos of acne and several common skin conditions to study participants and asked them their views about... (Source: Drugs.com - Daily MedNews)
Fri, 04 Mar 2016 07:00:00 +0100Title: Cystic AcneCategory: Diseases and ConditionsCreated: 3/4/2016 12:00:00 AMLast Editorial Review: 3/4/2016 12:00:00 AM (Source: MedicineNet Skin General)
Fri, 04 Mar 2016 05:00:00 +0100Updated Date: Mar 4, 2016 EST (Source: DailyMed Drug Label Updates)
Fri, 04 Mar 2016 01:43:36 +0100Mr. Lammer was among the first to establish a link between the acne medicine Accutane and human birth defects, and who became an advocate for the families of affected children. (Source: NYT Health)
Fri, 04 Mar 2016 00:00:00 +0100ConclusionThe results of our study suggest that ZnO may not only be an antimicrobial ingredient for the prevention of and treatment of acne. The results of our study suggest that ZnO may be an antimicrobial ingredient for the prevention of and treatment of acne when mixed with CA.This article is protected by copyright. All rights reserved. (Source: International Journal of Cosmetic Science)
Thu, 03 Mar 2016 05:00:00 +0100Updated Date: Mar 3, 2016 EST (Source: DailyMed Drug Label Updates)
Thu, 03 Mar 2016 00:00:00 +0100CONCLUSION: Hematuria was observed in 17% of the study group; this frequency rate was not different from that of the normal population. In subjects having isotretinoin treatment, if all the other reasons or disorders are excluded, one must keep in mind that hematuria may be due to isotretinoin use. PMID: 26938860 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Tue, 01 Mar 2016 06:00:00 +0100CONCLUSION: Potential factors that contribute to enlarged skin pores include excessive sebum, decreased elasticity around pores, and increased hair follicle volume. Because various factors cause enlarged facial pores, it might be useful to identify the underlying causes to be able to select the appropriate treatment. (Source: Dermatologic Surgery)
Tue, 01 Mar 2016 06:00:00 +0100CONCLUSION: This study confirmed the efficacy of both TCA and phenol for treating such scars, with less severe complications from the use of phenol. (Source: Dermatologic Surgery)
Tue, 01 Mar 2016 06:00:00 +0100CONCLUSION: The nonablative 1550-nm fractional laser is safe and efficacious in treating acne scaring in Fitzpatrick skin types IV to VI. Self-limited postinflammatory hyperpigmentation was a common occurrence, especially with higher treatment densities. (Source: Dermatologic Surgery)
Tue, 01 Mar 2016 06:00:00 +0100CONCLUSION: This study demonstrates that PDL is effective in reducing acne lesions using purpuric and subpurpuric fluences. However, there was no statistically significant difference in acne lesion count between the higher and lower fluences. (Source: Dermatologic Surgery)
Tue, 01 Mar 2016 06:00:00 +0100Conclusions: This study represents the largest cohort of ocular adnexal acne agminata, and revealed a spectrum of granulomatous subtypes, including coexistence of different granuloma subtypes within the same specimen. Lymphangiectases is a hallmark of this disorder, and varying features of tissue reaction are typical features of acne agminata. All of these cases were successfully cured by surgical resection of lesions without recurrence at last follow-up, and this modality should be considered the standard of care in the management of this problem. (Source: Ophthalmic Plastic and Reconstructive Surgery)
Tue, 01 Mar 2016 00:00:00 +0100Conclusion: This study showed significant impairment of QoL in acne patients. Assurance and counseling along with early treatment of acne vulgaris are important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment. (Source: Indian Journal of Dermatology)
Tue, 01 Mar 2016 00:00:00 +0100Conclusion: The pattern of dermatoses seen among the Nicobarese is quite similar with respect to the prevalence of infections in other regions of India, especially humid regions such as Assam, coastal Karnataka, and Kolkata and much higher than arid regions such as the deserts of Rajasthan. (Source: Indian Journal of Dermatology)
Sun, 28 Feb 2016 00:00:00 +0100ConclusionsPDT using topical MAL 80 mg g−1 and red light may offer promise for severe acne vulgaris. (Source: British Journal of Dermatology)
Sun, 28 Feb 2016 00:00:00 +0100ConclusionThe 755 nm alexandrite picosecond, 694 nm ruby, 532 nm, and 1064 nm neodynium:YAG nanosecond lasers appear to be safe and effective modalities for removal of pigmentary disorders in skin of color patients with no long‐term complications if used appropriately. This study demonstrates the potential of the 755 nm alexandrite picosecond laser in further clinical applications beyond tattoo removal. While the Q‐switched lasers were effective, promising results were also observed using an early version of the novel picosecond laser for the removal of pigmentary lesions in SOC patients. As we continue to improve our understanding of the 755 nm picosecond laser, this device may prove to be a safe and effective alternative to the Q‐switched lasers for the treatment of fac...
Sat, 27 Feb 2016 01:35:05 +0100PASS syndrome is a rare inflammatory disease characterized by a chronic-relapsing course of pyoderma gangrenosum, acne vulgaris, hidradenitis suppurativa and ankylosing spondylitis. Here, we describe a case of a patient with spontaneously recurrent purulent skin lesions along with seronegative spondylarthritis consistent with the PASS syndrome. During his disease exacerbation, the patient displayed episodes of fever along with elevated serum levels of interleukin (IL)-1β. Skin lesions were characterized by sterile neutrophilic infiltrates and showed a rapid response to the IL-1 receptor antagonist anakinra (Kineret®) consistent with the autoinflammatory nature of this disease. However, unlike other autoinflammatory diseases such as PAPA and PAPASH, we did not find mutations in the gene P...
Fri, 26 Feb 2016 05:00:00 +0100Updated Date: Feb 26, 2016 EST (Source: DailyMed Drug Label Updates)
Thu, 25 Feb 2016 22:02:11 +0100DUBLIN, Feb. 25, 2016 /PRNewswire/ -- Allergan plc (NYSE:AGN), a leading global pharmaceutical company, today announced that the Company has received approval from the U.S. Food and Drug Administration (FDA) to market Aczone (dapsone) Gel, 7.5%, a... (Source: Drugs.com - New Drug Approvals)
Thu, 25 Feb 2016 09:07:03 +0100Conclusion: This retrospective study shows that in patients with proposed SAPHO syndrome, the bone lesions are most likely located in ACW, and the configuration of the bullhead sign is characteristic, but not entirely sensitive. The value of upper costosternal junction involvement, especially the first rib, may be underevaluated. (Source: Nuclear Medicine Communications)
Thu, 25 Feb 2016 05:00:00 +0100Updated Date: Feb 25, 2016 EST (Source: DailyMed Drug Label Updates)
Thu, 25 Feb 2016 05:00:00 +0100Updated Date: Feb 25, 2016 EST (Source: DailyMed Drug Label Updates)
Thu, 25 Feb 2016 00:00:00 +0100Conclusion: This study demonstrated that adding platelet-rich plasma to fractional carbon dioxide laser treatment did not produce any statistically significant synergistic effects and also resulted in more severe side effects and longer downtime. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Wed, 24 Feb 2016 19:54:38 +0100Popping, squeezing, toothpaste-dabbing or wrapping a scarf around your entire face: You have no doubt attempted all methods under the sun to get rid of and conceal some nasty protrusions on your face at some point. Pimples are a part of life, no matter how much you may detest them. As explained in the AsapScience video above, they form when pores get clogged with bacteria, oils and dead skin cells, alerting the immune system that an infection is occurring. Your body responds by sending blood and white blood cells to the infected area, which unfortunately causes redness, whiteheads, blackheads and, sometimes, an entire "pizza face." Sadly, zits aren't just for kids. While adolescents are most at risk for pimply faces, we can get blemishes (or even acne) at any age. Stress is a big pimple-pr...
Wed, 24 Feb 2016 07:00:00 +0100Title: Double Up on Acne Treatments, New Guidelines SayCategory: Health NewsCreated: 2/23/2016 12:00:00 AMLast Editorial Review: 2/24/2016 12:00:00 AM (Source: MedicineNet Skin General)
Wed, 24 Feb 2016 00:00:00 +0100The objective of this review was to provide new insights into the role of traditional and novel ingredients in dermocosmetics for the treatment of acne, based on the authors’ objective assessment of the published literature. The type of products discussed include: those which have a sebostatic effect, such as topical antioxidants and niacinamide; agents targeting abnormal keratinization, such as salicylic acid, lipo‐hydroxy acid, alpha‐hydroxy acids, retinol‐based products and linoleic acid; agents targeting Propionibacterium acnes, such as lauric acid; and anti‐inflammatory agents such as nicotinamide, alpha‐linolenic acid and zinc salts. Despite the scientific advances in understanding these cosmetic ingredients, there still remains a lack of rigorous controlled studies in th...
Wed, 24 Feb 2016 00:00:00 +0100ConclusionBPO + CLN demonstrated greater efficacy than AzA in the treatment of mild‐to‐moderate acne vulgaris and has a positive tolerability and safety profile. (Source: Journal of the European Academy of Dermatology and Venereology)
Wed, 24 Feb 2016 00:00:00 +0100CONCLUSION: Our study is significant in that it is the first to investigate the effects of isotretinoin on visual contrast sensitivity that is closely associated with real-world performance. Our results need to be supported by future studies. PMID: 26911891 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Tue, 23 Feb 2016 20:16:45 +0100Skin doctors say combining two or more medications is often the best option (Source: WebMD Health)
Tue, 23 Feb 2016 00:00:00 +0100Publication date: Available online 23 February 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Katarzyna Piotrowska, Christina Wang, Ronald S Swerdloff, Peter Y Liu Family planning is a shared responsibility, but available male-directed contraceptive methods are either not easily reversible (vasectomy) or not sufficiently effective (condom). However, roughly 20% of couples using a contraceptive method worldwide, and up to 80% in some countries, still choose a male-directed method. Male hormonal contraception is highly effective, with perfect use failure rates of 0·6% (95% CI 0·3–1·1) if sperm concentrations of less than 1 million per mL are maintained. After cessation of male hormonal contraception, sperm output fully recovers in a predictable manner, resultin...
Mon, 22 Feb 2016 05:00:00 +0100Updated Date: Feb 22, 2016 EST (Source: DailyMed Drug Label Updates)
Mon, 22 Feb 2016 00:00:00 +0100CONCLUSIONS: Finding that sirolimus was unsafe and ineffective in patients with ADPKD and renal insufficiency suggests that mTOR inhibitor therapy may be contraindicated in this context. PMID: 26912555 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Sat, 20 Feb 2016 10:15:03 +0100Authors: Ferrazzi A, Russo I, Pasello G, Alaibac M Abstract Gefitinib is a selective epidermal growth factor receptor tyrosine kinase inhibitor utilized for the treatment of advanced non-small cell lung carcinoma. The most commonly reported adverse event during gefitinib therapy is skin rash, particularly a papulopustular acne-like eruption. Cutaneous toxicities can affect treatment compliance and the quality of life of the patient. The present study reports a case of gefitinib-induced atypical skin reaction in a 73-year-old woman with advanced non-small cell lung cancer, who developed a squamous-crusted eruption on her face after 4 weeks of oral treatment with gefitinib at a dose of 250 mg/day. The patient was treated with 100 mg minocyclin (2 tablets/day, orally) and with ryfamic...
Sat, 20 Feb 2016 06:29:02 +0100CONCLUSIONS: Our findings seems to provide favourable evidence of the efficacy and the safety of this new product in the maintenance treatment after O.I. in patient with moderate acne. The efficacy is maintain for a period as long as a year after O.I. suspension. PMID: 26889724 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)
Fri, 19 Feb 2016 14:19:41 +0100Abstract: A 14-year-old girl presented with a history of left-sided headache and acute bilateral blurred vision. She had a remote history of oral tetracycline use for the treatment of acne vulgaris, which had been discontinued for 1 month. The patient was diagnosed with drug-induced intracranial hypertension (IH) and treated with oral acetazolamide with subsequent resolution of symptoms. IH, a known rare complication of the tetracycline class of antibiotics, can also have a delayed presentation after discontinuation of the medication. (Source: Journal of Neuro-Ophthalmology)
Fri, 19 Feb 2016 14:08:30 +0100Sex cord stromal tumor, steroid cell, NOS is a rare tumor that accounts for < 0.1% of all ovarian tumors1. These tumors often have androgenic and virilizing symptoms. (Source: Journal of Pediatric and Adolescent Gynecology)
Fri, 19 Feb 2016 14:08:30 +0100The phenotypic presentation of nonclassic congenital adrenal hyperplasia (NCAH) in the pediatric and adolescent (PAG) population varies and include symptoms of hyperandrogenism such as premature pubarche in pre-menarchal (PM) girls and hirsutism, abnormal menses (AM), and acne in adolescents. Differentiating between premature adrenarche vs. NCAH in childhood and PCOS (polycystic ovary syndrome) vs. NCAH in adolescence is important; however, the recommendations regarding which patients should be screened for NCAH remains unclear. (Source: Journal of Pediatric and Adolescent Gynecology)
Fri, 19 Feb 2016 05:00:00 +0100Updated Date: Feb 19, 2016 EST (Source: DailyMed Drug Label Updates)
Thu, 18 Feb 2016 18:32:02 +0100Authors: Friedman A, Waite K, Brandt S, Meckfessel MH Abstract Nonadherence to topical acne therapies is a major contributing factor to poor treatment outcomes. Multiple contributing factors have been identified, including a lack of perceived efficacy and fear of side effects. A fixed-dose combination gel of adapalene/benzoyl peroxide gel, 0.1%/2.5% (A-BPO) is an efficacious and safe treatment for a range of acne severities in patients as young as 9 years old. A meta-analysis of 14 clinical studies involving A-BPO was conducted to assess the 4 week efficacy and overall tolerability of this treatment. Over 2,300 subjects were included in the analysis. Mean total, inflammatory, and non-inflammatory lesion counts decreased at 4 weeks by 40.8%, 46.2%, and 37.5%, respectively. Worst pos...
Thu, 18 Feb 2016 18:32:02 +0100CONCLUSIONS: Monotherapy with dapsone gel, 5% administered twice daily was safe and effective for treatment of facial acne in women with SOC. Significant improvement in overall acne severity and both inflammatory lesions and comedones was observed. Further, study subjects reported considerable improvement in both acne signs and impact on QOL.
Thu, 18 Feb 2016 18:32:02 +0100CONCLUSIONS: The combination oral doxycycline hyclate 100 mg with topical dapsone 5% gel twice daily is an effective and well-tolerated regimen to treat moderate to severe acne vulgaris. After discontinuation of doxycycline, topical dapsone 5% gel is effective at maintaining a therapeutic response. These data suggest that topical dapsone 5% gel can be used effectively for long-term acne maintenance treatment without the risk of developing antibiotic resistance.
Thu, 18 Feb 2016 18:32:02 +0100Authors: Kircik LH, Bhatt V, Martin G, Pillai R Abstract The use of fixed combinations in acne vulgaris (acne) is very common, however comparative clinical trial data are limited. Cutaneous tolerability can influence patient compliance, and concerns about skin irritation with topical acne treatments have lead to a number of comparative split-face studies.
Thu, 18 Feb 2016 05:00:00 +0100Updated Date: Feb 18, 2016 EST (Source: DailyMed Drug Label Updates)
Thu, 18 Feb 2016 00:00:00 +0100ConclusionClinical hyperandrogenism is not a good predictor for biochemical hyperandrogenism in Thai women with PCOS. A modified Ferriman–Gallwey score cut‐off point of 8 has low sensitivity but high specificity for hyperandrogenemia; therefore, it is useful for the diagnosis but not useful for the exclusion of hyperandrogenemia in Thai women with PCOS. (Source: Journal of Obstetrics and Gynaecology Research)
Wed, 17 Feb 2016 17:44:02 +0100Authors: Aslam I, Fleischer A, Feldman S Abstract INTRODUCTION: Acne is the most common skin condition in the US. The mainstay of acne therapy includes: topical retinoids, topical antibiotics, benzoyl peroxide (BP), and oral isotretinoin for severe cases. Although these treatment options are highly effective they do have certain drawbacks. Current acne treatment regimens often require patients to use multiple medications, some of which may have irritating side effects. Furthermore, Propionibacterium acnes resistance to antibiotics has become an increasing problem due to the rise in antibiotic use. AREAS COVERED: New therapies that have either been released onto the market or that are being developed include: adapalene-BP combination agent, dapsone 5% gel, minocycline foam, topi...
Wed, 17 Feb 2016 17:43:02 +0100Authors: Smith JA, Narahari S, Hill D, Feldman SR Abstract INTRODUCTION: Acne is a common skin condition of the pilosebaceous units that affects the young and old, ranges from moderate to severe and can be treated with an array of options. Topical retinoids are the initial treatment for acne due to their ability to treat comedones, the starting point of acne. AREAS COVERED: Tazarotene is a topical retinoid available as a cream, gel and foam. Tazarotene 0.1% foam was FDA approved in 2012 for the treatment of acne in patients ages ≥12 and is the first foam topical retinoid on the market. Phase I and III trials support the efficacy and safety of tazarotene foam for acne. EXPERT OPINION: The foam vehicles may increase compliance and satisfaction in some patients and as retino...
Wed, 17 Feb 2016 14:01:33 +0100WAIKOLOA, HAWAII – Three new approaches to topical treatment of acne are on the horizon, and they all share a common foe: sebum. “One exciting new avenue for topical therapy are drugs that actually target the production of sebum,” explained Dr. Linda F. Stein Gold, director of dermatology research... (Source: Skin and Allergy News)
Wed, 17 Feb 2016 07:07:02 +0100CONCLUSIONS: Topical treatments with retinoids, antibiotics and antiseptics may increase skin irritation reducing patient adherence to the treatment. HSD gel has shown a good skin tolerability and efficacy in reducing acne lesions, even during the sun exposure period in which traditional treatments should be cautiously used. PMID: 26875890 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Wed, 17 Feb 2016 07:07:02 +0100CONCLUSIONS: 3.6% ALA-PDT is a simple, safe and effective therapeutic option for the treatment of severe acne vulgaris. PMID: 26875889 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Wed, 17 Feb 2016 00:00:00 +0100Acne is one of the most common disorders treated by dermatologists and other health care providers. While it most often affects adolescents, it is not uncommon in adults and can also be seen in children. This evidence-based guideline addresses important clinical questions that arise in its management. Issues from grading of acne to the topical and systemic management of the disease are reviewed. Suggestions on use are provided based on available evidence. (Source: Journal of the American Academy of Dermatology)
Wed, 17 Feb 2016 00:00:00 +0100Conclusion Two patient-reported measures, SCARS and FASQoL, have been developed to help clinicians assess the severity and impact of acne scars. Responsivity of these instruments to treatment will require further evaluation. Funding Galderma R&D, Sophia Antipolis, France. (Source: Dermatology and Therapy)
Tue, 16 Feb 2016 15:15:00 +0100In recent... (Source: Cutis: Cutaneous Medicine for the Practitioner)
Tue, 16 Feb 2016 05:00:00 +0100Updated Date: Feb 16, 2016 EST (Source: DailyMed Drug Label Updates)
Tue, 16 Feb 2016 03:36:02 +0100Authors: Jain A, Garg NK, Jain A, Kesharwani P, Jain AK, Nirbhavane P, Tyagi RK Abstract The present study documents the fabrication and characterization of a topically applicable gel loaded with nanostructured lipid carriers (NLCs) of adapalene (ADA) and vitamin C (ascorbyl-6-palmitate [AP]). The NLCs were prepared by high pressure homogenization (HPH) method followed by incorporation into AP loaded gel. The fabricated system was characterized for size, poly dispersity index, entrapment efficiency (EE) and in vitro drug release properties, and was further investigated for skin compliance, skin transport characteristics (skin permeation and bio-distribution), rheological behavior, texture profile analysis and anti-acne therapeutic potential against testosterone-induced acne in male...
Tue, 16 Feb 2016 03:23:09 +0100CONCLUSION: The results of this survey cannot be compared with other studies because of the lack of similar studies about this topic. These results suggest that a sample of Italian acne patients consider cleansers as an important adjuvant treatment in acne. PMID: 26822550 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Tue, 16 Feb 2016 03:23:09 +0100CONCLUSION AND RELEVANCE: The ICGS is reproducible and relatively simple to use. It can be incorporated as an objective tool to aid in the assessment of isotretinoin associated cheilitis. PMID: 26395167 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Tue, 16 Feb 2016 03:23:09 +0100CONCLUSIONS: The concomitant usage of adapalene gel and the moisturizer containing licochalcone A, l-carnitine and 1,2-decanediol could reduce undesirable side effects without interfering the efficacy of adapalene. This moisturizer may be superior to placebo to prevent cutaneous irritations and enhance patients' adherence to acne medications. PMID: 26293170 [PubMed - in process] (Source: Journal of Dermatological Treatment)
Tue, 16 Feb 2016 03:23:09 +0100This study showed that the subjects with family history (especially paternal history) were prone to develop severe acne (p < 0.001). Besides, patients with severe acne might exhibit more severe psychological disorders (p < 0.001). The most frequently used methods were pharmacological treatments. These results indicate that acne is prone to induce severe psychological disorders, and could be affected by multiple factors. Furthermore, these results provide valuable reference for exploring the preventive measures and treatments of acne in Shanghai area of China. PMID: 26194720 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Tue, 16 Feb 2016 00:00:00 +0100Conclusions Treatment of FtM gender dysphoric adolescents with lynestrenol monotherapy and in combination with testosterone esters is effective, safe, and inexpensive; however, suppression of gonadotropins is incomplete. Regular blood controls allow screening for unphysiological changes in safety parameters or hormonal levels and for medication abuse. (Source: Biology of Sex Differences)
Tue, 16 Feb 2016 00:00:00 +0100Parents are constantly “screening” their children from birth, anxiously making sick-visit appointments with their pediatrician for issues as simple as transient neonatal acne, “stork bite” nevus complex, or an occasional viral illness. Parents excitedly watch for developmental milestones—eg, eye contact, cooing, social smile, babbling, sitting, crawling. In every state of the union, early childhood intervention programs are mandated to formally evaluate and in many cases treat every child whose parents have a developmental concern prior to age 3 years. Developmental assessments are performed by a clinical care professional at each pediatrician visit. If parents raise a developmental concern, they are reassured and the child is further tested or referred to specialists or early ch...
Tue, 16 Feb 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. PMID: 26879264 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)