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MedWorm: Dilated Cardiomyopathy



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Dilated Cardiomyopathy category.



Last Build Date: Tue, 22 Mar 2016 08:22:41 +0100

 



Differences in predictors of implantable cardioverter-defibrillator therapies in patients with ischaemic and non-ischaemic cardiomyopathies

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion The aetiology of cardiomyopathy should be taken into consideration for the therapy of ICD patients. The protective role of CRT devices should be pointed out in ischaemic cardiomyopathy (ICM) and a more rigorous antiarrhythmic treatment should be considered for ICM patients with secondary prevention or for dilated cardiomyopathy patients with AF. (Source: Europace)

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Impact of common β1-adrenergic receptor polymorphisms on the interaction with agonistic autoantibodies in dilated cardiomyopathy

Mon, 21 Mar 2016 00:00:00 +0100

Human populations exhibit significant allele frequencies of two non-synonymous single nucleotide polymorphisms within the coding block of the β1-adrenergic receptor (β1AR) gene, which cause alternative incorporation of amino acids at positions 49 (Gly/Ser) and 389 (Gly/Arg) of the receptor protein and give rise to functionally distinct β1AR-variants [1]. Receptors encoded by the allele β1AR389Arg are more effective in promoting baseline and agonist-stimulated cAMP-production as compared to β1AR389Gly, while receptors encoded by the allele β1AR49Gly are more prone to agonist-induced internalisation and desensitisation as compared to β1AR49Ser [2]. (Source: International Journal of Cardiology)



Emerging Pharmacologic Targets and Treatments for Myocarditis

Mon, 21 Mar 2016 00:00:00 +0100

Publication date: Available online 20 March 2016 Source:Pharmacology & Therapeutics Author(s): Lionel D. Jensen, David J. Marchant Myocarditis is a heterogeneous group of disorders defined by inflammation of the heart muscle. The primary clinical manifestations of myocarditis are heart failure and sudden death in children and young adults. Numerous interventions have been investigated for the treatment of myocarditis, including broad spectrum alteration of the immune response and antiviral treatments; however, success has been limited. Since the myocarditis treatment trials in the 1990s there has been an improved understanding of disease progression and new facets of the immune response have been discovered. This new information provides fresh opportunities to develop therapeut...



The Correlation of PPARα Activity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression.

Fri, 18 Mar 2016 01:32:02 +0100

In conclusion, PPARα elevated levels may be a direct cause of adverse remodeling, both metabolic and structural. Thus, there is limited time window for therapy modulating cardiac metabolism and protecting cardiomyocyte structure in failing heart. PMID: 26981112 [PubMed] (Source: PPAR Research)



The utility of shock coil and left ventricular tip–right ventricular coil impedance as a predictor of pneumothorax in cardiac resynchronization therapy implantation

Fri, 18 Mar 2016 00:00:00 +0100

Publication date: Available online 17 March 2016 Source:Journal of Cardiology Cases Author(s): Masashi Kamioka, Minoru Nodera, Hitoshi Suzuki, Yasuchika Takeishi A high defibrillation threshold (DFT) infrequently occurs during device implantation. The major cause of high DFT is pneumothorax. However, there are few data about shock coil and left ventricular tip–right ventricular coil (LV tip–RV coil) impedance as a marker of a high DFT caused by pneumothorax. A 65-year-old man, diagnosed with dilated cardiomyopathy, was referred for cardiac resynchronization therapy (CRT) defibrillator implantation with single shock coil lead. The shock coil impedance was high and LV tip–RV coil impedance was normal just before DFT test. Then, high DFT was detected. Afterwards, pneumothorax was ...



Five-year mortality in cardiac surgery patients with low cardiac output syndrome treated with levosimendan: prognostic evaluation of NT-proBNP and C-reactive protein.

Thu, 17 Mar 2016 01:39:01 +0100

CONCLUSIONS: The presence of dilated cardiomyopathy, elevated CVP at 48 h and reduced CRP levels on day 7 predicted 5-year mortality in patients who developed postoperative LCOS after cardiac surgery. NT-proBNP levels in the first postoperative week were not predictors of long-term outcomes. PMID: 26977768 [PubMed - as supplied by publisher] (Source: Minerva Cardioangiologica)

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The differences in left atrial function between ischemic and idiopathic dilated cardiomyopathy patients: A two‐dimensional speckle tracking imaging study

Wed, 16 Mar 2016 00:00:00 +0100

ConclusionsLA basic echocardiographic variables did not reflect the differences between ICM and DCM patients, but the systolic and late diastolic strain, as well as the strain rate, were lower in DCM patients. Two‐dimensional speckle‐tracking imaging is a promising method to differentiate these patients. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound, 2016 (Source: Journal of Clinical Ultrasound)



Two rare neurologic complications after heart transplantation: Posterior reversible encephalopathy syndrome, followed by reversible cerebral vasoconstriction syndrome

Mon, 14 Mar 2016 00:00:00 +0100

A 50-year-old man with dilated cardiomyopathy had persistent dyspnea despite receiving guideline-directed medical treatment, including cardiac resynchronization therapy. He underwent heart transplantation, which was successful without complications. (Source: The Journal of Heart and Lung Transplantation)



Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

Mon, 14 Mar 2016 00:00:00 +0100

CONCLUSIONS: Together, our findings suggest that cardiac myocyte GSK-3 is required to maintain normal cardiac homeostasis and its loss is incompatible with life due to cell cycle dysregulation that ultimately results in a severe fatal dilated cardiomyopathy. PMID: 26976650 [PubMed - as supplied by publisher] (Source: Circulation Research)



Left Ventricular Non Compaction A rare form of cardiomyopathy: Revelation modes and predictors of mortality in adults through 23 cases

Fri, 11 Mar 2016 00:00:00 +0100

Conclusions LVNC should be looked for at any dilated cardiomyopathy particularly in young patients. It requires a careful echocardiographic examination and sometimes CMR to confirm the diagnosis. It is characterized by severe systolic and diastolic dysfunction that would provide poor prognosis. (Source: Journal of the Saudi Heart Association)



Dilated cardiomyopathy mutations in delta sarcoglycan exert a dominant negative effect on cardiac myocyte mechanical stability.

Fri, 11 Mar 2016 00:00:00 +0100

This study demonstrates that DCM mutant delta sarcoglycans can be stably expressed in adult rat cardiac myocytes and traffic similarly to wild-type delta sarcoglycan to the plasma membrane, without perturbing assembly of the dystrophin-glycoprotein complex. However, expression of DCM mutant delta sarcoglycan in adult rat cardiac myocytes is sufficient to alter cardiac myocyte plasma membrane stability in the presence of mechanical strain. Upon cyclical cell stretching cardiac myocytes expressing mutant delta sarcoglycan R97Q or R71T have increased cell-impermeant dye uptake and undergo contractures at greater frequencies than myocytes expressing normal delta sarcoglycan. Additionally, the R71T mutation creates an ectopic N-linked glycosylation site that results in aberrant glycosylation of...

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A novel c.563 T>G, p.L189R lamin A/C mutation in identical twins with dilated cardiomyopathy.

Tue, 08 Mar 2016 00:00:00 +0100

Authors: Lee E, Park KT, Kang J, Park H, Park JJ, Oh IY, Yoon YE PMID: 26951916 [PubMed - as supplied by publisher] (Source: The Korean Journal of Internal Medicine)



Left ventricular systolic function assessment in secondary mitral regurgitation: left ventricular ejection fraction vs. speckle tracking global longitudinal strain

Mon, 07 Mar 2016 00:00:00 +0100

Conclusion In patients with severe secondary MR, speckle-tracking GLS shows more deteriorated LV systolic function than LVEF. (Source: European Heart Journal)



A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy

Mon, 07 Mar 2016 00:00:00 +0100

We describe a targeted metabolomics assay that quantifies a broad range of over 130 metabolites relevant to cardiac metabolism including the pathways of the citric acid cycle, fatty acid oxidation, glycolysis, the pentose phosphate pathway, amino acid metabolism, the urea cycle, nucleotides and reactive oxygen species using tandem mass spectrometry to produce quantitative, sensitive and robust data. This assay is illustrated by profiling cardiac metabolism in a lamin A/C (Lmna) mouse model of dilated cardiomyopathy (DCM). The model of DCM was characterised by increases in concentrations of proline and methyl-histidine suggestive of increased myofibrillar and collagen degradation, as well as decreases in a number of citric acid cycle intermediates and carnitine derivatives indicating reduce...



Instrumentation to Study Myofibril Mechanics from Static to Artificial Simulations of Cardiac Cycle

Thu, 03 Mar 2016 00:00:00 +0100

Publication date: Available online 2 March 2016 Source:MethodsX Author(s): Petr G. Vikhorev, Michael A. Ferenczi, Steven B. Marston Many causes of heart muscle diseases and skeletal muscle diseases are inherited and caused by mutations in genes of sarcomere proteins which play either a structural or contractile role in the muscle cell. Tissue samples from human hearts with mutations can be obtained but often samples are only a few milligrams and it is necessary to freeze them for storage and transportation. Myofibrils are the fundamental contractile components of the muscle cell and retain all structural elements and contractile proteins performing in contractile event; moreover viable myofibrils can be obtained from frozen tissue. We are describing a versatile technique for measuring...



Megaconial muscular dystrophy caused by mitochondrial membrane homeostasis defect, new insights from skeletal and heart muscle analyses

Thu, 03 Mar 2016 00:00:00 +0100

This study describes a patient presenting with the cardinal clinical features, in whom a homozygous nonsense mutation (c.248_249insT; p.Arg84Profs*209) was identified in CHKB and who was treated by heart transplantation. Microscopic evaluation of skeletal and heart muscles typically showed enlarged mitochondria. Spectrophotometric evaluation in both tissues revealed a mild decrease of all OXPHOS complexes. Using BN-PAGE analysis followed by activity staining subcomplexes of complex V were detected in both tissues, indicating incomplete complex V assembly. Mitochondrial DNA content was not depleted in analysed tissues. This is the first report describing the microscopic and biochemical abnormalities in the heart from an affected patient. A likely hypothesis is that the biochemical findings ...

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Left Atrial Size and Function: Impact on LV Predicting Reverse Remodeling and Events in New-Onset Dilated Cardiomyopathy

Thu, 03 Mar 2016 00:00:00 +0100

“It's tough to make predictions, especially about the future” (Source: Journal of Cardiac Failure)



The Pythian Left Atrium: Predicting LV Reverse Remodeling and Cardiovascular Events in New-Onset Dilated Cardiomyopathy

Thu, 03 Mar 2016 00:00:00 +0100

“It's tough to make predictions, especially about the future” (Source: Journal of Cardiac Failure)



Electrocardiographic Repolarization Abnormalities and Increased Risk of Life-threatening Arrhythmias in Children with Dilated Cardiomyopathy

Wed, 02 Mar 2016 00:00:00 +0100

Life-threatening arrhythmia events (LTEs) occur in approximately 5% of children with dilated cardiomyopathy (DCM). While prolonged QRS has been shown to be associated with LTEs, electrocardiographic (ECG) repolarization findings have not been examined. (Source: Heart Rhythm)



Prothrombin Complex Concentrate and Methylene Blue for Treatment of Coagulopathy and Vasoplegia in a Pediatric Heart Transplant Patient

Tue, 01 Mar 2016 06:00:00 +0100

We describe a case in which these conditions were successfully treated with no thrombotic complications and minimal need of vasopressors for hemodynamic stability. (Source: A&A Case Reports)



Incremental value of coronary CTA in patients with new onset dilated cardiomyopathy

Tue, 01 Mar 2016 00:00:00 +0100

Background and aim: Dilated Cardiomyopathy (DCM) is a common disease with high morbidity and mortality. While atherosclerotic coronary artery disease (CAD) is a common cause of a group of DCM; known as ischemic cardiomyopathy (CMP). There is another group of DCM which develops secondary to systemic diseases, drug exposure or even idiopathic; this group is known as non-ischemic CMP. Management and prognosis of DCM is variable between ischemic and ischemic CMP. Exclusion of significant atherosclerotic CAD therefore, is an important step in the management of DCM. (Source: Journal of Cardiovascular Computed Tomography)

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Phospholamban p.Arg14del cardiomyopathy is characterized by phospholamban aggregates, aggresomes and autophagic degradation

Tue, 01 Mar 2016 00:00:00 +0100

ConclusionsPhospholamban p.Arg14del cardiomyopathy is a biventricular cardiomyopathy characterized by large perinuclear PLN protein aggregates with a typical ultrastructural appearance of aggresomes. Immunohistochemistry for PLN appears to be a sensitive and specific marker for this disease.This article is protected by copyright. All rights reserved. (Source: Histopathology)



Clinical significance of endomyocardial biopsy in conjunction with cardiac magnetic resonance imaging to predict left ventricular reverse remodeling in idiopathic dilated cardiomyopathy

Fri, 26 Feb 2016 00:00:00 +0100

Abstract Endomyocardial biopsy (EMB) and cardiac magnetic resonance (CMR) are useful modalities to study the characteristics of myocardial tissue. However, the prognostic impact of both diagnostic tools to predict subsequent left ventricular reverse remodeling (LVRR) has not been well elucidated. A total of 187 consecutive patients with idiopathic dilated cardiomyopathy (IDCM) who were treated by optimal pharmacotherapy (OPT) and underwent EMB of the LV wall were investigated. The myocardial specimens were semiquantitatively evaluated measuring cardiomyocyte degeneration (CD), interstitial fibrosis (IF), and hypertrophy. In addition, late gadolinium enhancement (LGE)-CMR was performed in 78 (48 %) patients. Seventy-eight (48 %) patients developed LVRR, defined as a ≥10 % incr...



Mechanical dyssynchrony and deformation imaging in patients with functional mitral regurgitation.

Fri, 26 Feb 2016 00:00:00 +0100

Authors: Rosa I, Marini C, Stella S, Ancona F, Spartera M, Margonato A, Agricola E Abstract Chronic functional mitral regurgitation (FMR) is a frequent finding of ischemic heart disease and dilated cardiomyopathy (DCM), associated with unfavourable prognosis. Several pathophysiologic mechanisms are involved in FMR, such as annular dilatation and dysfunction, left ventricle (LV) remodeling, dysfunction and dyssynchrony, papillary muscles displacement and dyssynchrony. The best therapeutic choice for FMR is still debated. When optimal medical treatment has already been set, a further option for cardiac resynchronization therapy (CRT) and/or surgical correction should be considered. CRT is able to contrast most of the pathophysiologic determinants of FMR by minimizing LV dyssynchrony ...



Prognostic Implication of Three-Dimensional Mitral Valve Tenting Geometry in Dilated Cardiomyopathy.

Thu, 25 Feb 2016 20:41:02 +0100

CONCLUSION: The 3D tenting pattern, assessed with RT3DE, would be an important clinical parameter in predicting long-term prognosis in patients with DCM. PMID: 26897836 [PubMed - in process] (Source: Journal of Heart Valve Disease)



Anesthetic Management and Outcomes of Parturients With Dilated Cardiomyopathy in an Academic Center

Thu, 25 Feb 2016 10:19:41 +0100

(Can J Anesth. 2015;62:278–288) Cardiomyopathy is increasing as a cause of maternal death, up from 8% in 1991 to 1997 to over 12% in 1998 to 2005. A 2002 study in North Carolina showed cardiomyopathy to be the leading cause of maternal death, accounting for >20% of deaths. (Source: Obstetric Anesthesia Digest)

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Incidence of and predictors for appropriate implantable cardioverter-defibrillator therapy in patients with a secondary preventive implantable cardioverter-defibrillator indication

Thu, 25 Feb 2016 00:00:00 +0100

Conclusion The rate of appropriate ICD therapies in secondary prevention is high. No useful predictors for them, especially not for life-threatening arrhythmias could be identified. (Source: Europace)



Epicardial only mapping and ablation of ventricular tachycardia: a case series

Thu, 25 Feb 2016 00:00:00 +0100

Conclusion Epicardial only ablation seems feasible and effective and useful in a limited subset of patients with incessant VT. However, endpoints are more difficult to evaluate and long-term follow-up is needed. (Source: Europace)



The role of mutations in the SCN5A gene in cardiomyopathies

Wed, 24 Feb 2016 00:00:00 +0100

This article is part of a Special Issue entitled:Cardiomyocyte Biology: Integration of Develomental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)



Implantable Cardioverter-Defibrillator Discharge in a Patient with Dilated Cardiomyopathy

Wed, 24 Feb 2016 00:00:00 +0100

This article discusses a case in which the diagnosis of typical atrioventricular nodal reciprocating tachycardia could be firmly established from the implantable cardioverter-defibrillator interrogation alone. (Source: Cardiac Electrophysiology Clinics)



Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure.

Tue, 23 Feb 2016 00:00:00 +0100

Authors: Sakamuri SS, Takawale A, Basu R, Fedak PW, Freed D, Sergi C, Oudit GY, Kassiri Z Abstract Adverse remodeling of the extracellular matrix (ECM) is a significant characteristic of heart failure. Reverse remodeling of the fibrillar ECM secondary to mechanical unloading of the left ventricle (LV) by left ventricular assist device (LVAD) has been subject of intense investigation; however, little is known about the impacts on nonfibrillar ECM and matricellular proteins that also contribute to disease progression. Explanted failing hearts were procured from patients with nonischemic dilated cardiomyopathy (DCM) with or without LVAD support, and compared to nonfailing control hearts. LV free wall specimens were formalin-fixed, flash-frozen or OCT-mount frozen. Histologic and bioch...

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Differential Impact of Mechanical Unloading on Structural and Non-Structural Components of the Extracellular Matrix in Advanced Human Heart Failure

Mon, 22 Feb 2016 00:00:00 +0100

Adverse remodeling of the extracellular matrix (ECM) is a significant characteristic of heart failure. Reverse remodeling of the fibrillar ECM secondary to mechanical unloading of the left ventricle (LV) by LV assist device (LVAD) has been subject of intense investigation, however little is known about the impacts on non-fibrillar ECM and matricellular proteins that also contribute to disease progression. Explanted failing hearts were procured from patients with non-ischemic dilated cardiomyopathy (DCM) with or without LVAD support, and compared to non-failing control hearts (NFC). (Source: Translational Research)



Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure

Mon, 22 Feb 2016 00:00:00 +0100

Adverse remodeling of the extracellular matrix (ECM) is a significant characteristic of heart failure. Reverse remodeling of the fibrillar ECM secondary to mechanical unloading of the left ventricle (LV) by left ventricular assist device (LVAD) has been subject of intense investigation; however, little is known about the impacts on nonfibrillar ECM and matricellular proteins that also contribute to disease progression. Explanted failing hearts were procured from patients with nonischemic dilated cardiomyopathy (DCM) with or without LVAD support, and compared to nonfailing control hearts. (Source: Translational Research)



Is cardiac and hepatic iron status assessed by MRI T2* associated with left ventricular function in patients with idiopathic cardiomyopathy?

Sat, 20 Feb 2016 00:00:00 +0100

Abstract Excess accumulation of iron in the heart is known to aggravate cardiac function in some cases of genetic and acquired iron overload. We investigated the possible association between cardiac function and iron content in the heart and liver, estimated non-invasively by T2 star (T2*)-weighted magnetic resonance (MR) imaging among patients with cardiomyopathy. MR images were acquired on a 3.0 T MR imaging system using an 8-channel phased-array cardiac coil. Average T2* values of the heart were estimated at regions of interest that were located on short axis mid-ventricular slices positioned at the cardiac septum. In total, 82 patients were enrolled: 48 patients with dilated cardiomyopathy (DCM), 16 patients with hypertrophic cardiomyopathy (HCM), and 18 patients without appa...



Role of cardiac TBX20 in dilated cardiomyopathy.

Fri, 19 Feb 2016 00:00:00 +0100

Authors: Mittal A, Sharma R, Prasad R, Bahl A, Khullar M Abstract Dilated cardiomyopathy (DCM) is an important cause of heart failure and sudden cardiac death worldwide. Transcription factor TBX20 has been shown to play a crucial role in cardiac development and maintenance of adult mouse heart. Recent studies suggest that TBX20 may have a role in pathophysiology of DCM. In the present study, we examined TBX20 expression in idiopathic DCM patients and in an animal model of cardiomyopathy, and studied its correlation with echocardiographic indices of LV function. Endomyocardial biopsies (EMBs) from intraventricular septal from the right ventricle region were obtained from idiopathic DCM patients (IDCM, n = 30) and from patients with ventricular septal defect (VSD, n = 14) with no...



Plasma microRNA profiling of children with idiopathic dilated cardiomyopathy.

Thu, 18 Feb 2016 02:43:03 +0100

DISCUSSION: miRNA level differences may provide the chance of using these miRNAs as new biomarkers. PMID: 26631154 [PubMed - as supplied by publisher] (Source: Biomarkers)

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Maintenance Treatment by Erlotinib and Toxic Cardiomyopathy: A Case Report.

Thu, 18 Feb 2016 00:00:00 +0100

We report the case of a 71-year-old woman with metastatic NSCLC treated with cisplatin/pemetrexed and then erlotinib maintenance therapy. After 26 months of TKI therapy, she developed dilated cardiomyopathy. Despite symptomatic treatment, left ventricular ejection fraction decreased to 25%. Ischemic heart disease was excluded by coronary angiography and cardiac magnetic resonance imaging, and no other cause was found. Erlotinib was stopped, and cardiac resynchronization therapy by pacemaker was initiated. This case report highlights the possible cardiotoxic effects of long-term erlotinib and suggests the need for close clinical and echocardiographic follow-up of patients receiving long-term TKI therapy. PMID: 26886479 [PubMed - as supplied by publisher] (Source: Oncology)



Autophagic vacuoles in cardiomyocytes of dilated cardiomyopathy with initially decompensated heart failure predict improved prognosis.

Thu, 18 Feb 2016 00:00:00 +0100

In conclusion, autophagic vacuoles in cardiomyocytes are associated with a better HF prognosis in patients with DCM, suggesting autophagy may play a role in the prevention of myocardial degeneration. PMID: 26890610 [PubMed - as supplied by publisher] (Source: Autophagy)



Maintenance Treatment by Erlotinib and Toxic Cardiomyopathy: A Case Report

Wed, 17 Feb 2016 17:12:45 +0100

We report the case of a 71-year-old woman with metastatic NSCLC treated with cisplatin/pemetrexed and then erlotinib maintenance therapy. After 26 months of TKI therapy, she developed dilated cardiomyopathy. Despite symptomatic treatment, left ventricular ejection fraction decreased to 25%. Ischemic heart disease was excluded by coronary angiography and cardiac magnetic resonance imaging, and no other cause was found. Erlotinib was stopped, and cardiac resynchronization therapy by pacemaker was initiated. This case report highlights the possible cardiotoxic effects of long-term erlotinib and suggests the need for close clinical and echocardiographic follow-up of patients receiving long-term TKI therapy.Oncology (Source: Oncology)



Clinical management of dilated cardiomyopathy: current knowledge and future perspectives.

Wed, 17 Feb 2016 15:49:03 +0100

Authors: Merlo M, Cannatá A, Vitagliano A, Zambon E, Lardieri G, Sinagra G Abstract Dilated cardiomyopathy (DCM) is a primary heart muscle disease characterized by a progressive dilation and dysfunction of either the left or both ventricles. The management of DCM is currently challenging for clinicians. The persistent lack of knowledge about the etiology and pathophysiology of this disease continues to determine important fields of uncertainty in managing this condition. Molecular cardiology and genetics currently represent the most crucial horizon of increasing knowledge. Understanding the mechanisms underlying the disease allows clinicians to treat this disease more effectively and to further improve outcomes of DCM patients through advancements in etiologic characterization, pr...



Neutrophil/lymphocyte ratio is related to the severity of idiopathic dilated cardiomyopathy.

Wed, 17 Feb 2016 15:42:02 +0100

CONCLUSION: Neutrophil/Lymphocyte ratio is associated with the severity of chronic heart failure in patients with idiopathic DCM. PMID: 24912526 [PubMed - indexed for MEDLINE] (Source: Scandinavian Cardiovascular Journal)

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Association of innate immune IFIH1 gene polymorphisms with dilated cardiomyopathy in a Chinese population.

Wed, 17 Feb 2016 14:24:02 +0100

Authors: Dou Q, Peng Y, Zhou B, Lin J, Li Y, Yang H, Xie Q, Li C, Zhang L, Rao L Abstract The interferon-induced helicase C domain-containing protein 1 (IFIH1) is a cytosolic RNA sensor belonging to the pattern-recognition receptor (PPR) family. Activation of PPRs on innate immune cells is widely believed to control the development of virus-induced autoimmunity in myocarditis and subsequent dilated cardiomyopathy (DCM). We conducted a pilot study to test whether single nucleotide polymorphisms (SNPs) in IFIH1 were associated with the risk and prognosis of DCM. The TaqMan SNP Genotyping Assay was used to genotype rs1990760 and rs3747517 in 351 DCM patients and 359 controls. The frequency of T allele and CT/TT genotypes at rs1990760 were significantly increased in DCM patients compar...



Complexities of Genetic Testing in Familial Dilated Cardiomyopathy [Clinical Genomic Cases]

Tue, 16 Feb 2016 00:00:00 +0100

(Source: Circulation: Cardiovascular Genetics)



A novel overlapping phenotype characterized by lipodystrophy, mandibular dysplasia, and dilated cardiomyopathy associated with a new mutation in the gene

Mon, 15 Feb 2016 00:00:00 +0100

A 31-year old heart transplant recipient presented for genetic counseling. He was born to nonconsanguineous healthy parents of European descent. A dilated cardiomyopathy was diagnosed at the age of 12years and heart transplantation was performed few months later. Pathologic examination of the explanted heart showed myocardial hypertrophy and interstitial fibrosis (Fig. 1). At the gross examination, the right ventricle, interventricular septum, and left ventricle of the explanted heart were 5mm, 11mm, and 13mm of thickness, respectively. (Source: International Journal of Cardiology)



Whole exome sequence analysis reveals a homozygous mutation in as the cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease

Sat, 13 Feb 2016 00:00:00 +0100

Neutral lipid storage disease with myopathy (NLSD-M; PNPLA2) is a rare, mostly autosomal recessive disorder, caused by mutations in the gene encoding patatin-like phospholipase domain-containing protein 2 (PNPLA2), also known as adipose triglyceride lipase (ATGL). ATGL catalyses the breakdown of triacylglycerol (TAG) to diacylglycerol. Dysfunction of ATGL leads to accumulation of TAG-containing cytoplasmic vacuoles in most tissues [1]. Only about 40 patients have been described with NLSD-M worldwide. (Source: International Journal of Cardiology)



Perfusion and metabolic scintigraphy with 123 I-BMIPP in prognosis of cardiac resynchronization therapy in patients with dilated cardiomyopathy

Fri, 12 Feb 2016 00:00:00 +0100

Conclusion Data of metabolic scintigraphy may be useful for the integrated prediction of CRT efficacy. (Source: Annals of Nuclear Medicine)

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Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1{alpha}/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1{alpha} and Regulates Responsive Cardiac Angiogenesis [Heart]

Wed, 10 Feb 2016 00:00:00 +0100

In this study, we identified Rnd3, a small Rho GTPase, as a proangiogenic factor participating in the regulation of the HIF1α–VEGF signaling cascade. Rnd3 physically interacted with and stabilized HIF1α, and consequently promoted VEGFA expression and endothelial cell tube formation. To demonstrate this proangiogenic role of Rnd3 in vivo, we generated Rnd3 knockout mice. Rnd3 haploinsufficient (Rnd3+/–) mice were viable, yet developed dilated cardiomyopathy with heart failure after transverse aortic constriction stress. The poststress Rnd3+/– hearts showed significantly impaired angiogenesis and decreased HIF1α and VEGFA expression. The angiogenesis defect and heart failure phenotype were partially rescued by cobalt chloride treatment, a HIF1α stabi...



Unclassifiable arrhythmic cardiomyopathy associated with Emery-Dreifuss caused by a mutation in FHL1.

Tue, 09 Feb 2016 00:00:00 +0100

Authors: Román IS, Navarro M, Martínez F, Albert L, Polo L, Guardiola J, García-Molina E, Muñoz-Esparza C, López-Ayala JM, Molina MS, Gimeno JR Abstract Emery-Dreifuss muscular dystrophy (EDMD) is a heterogeneous genetic disorder characterized by peripheral muscular weakness often associated with dilated cardiomyopathy. We characterize clinically a large family with a mutation in FHL1 gene (p.Cys255Ser). Penetrance was 44%, 100% for males and 18% for females. The heart was the main organ involved. Affected adult males had mild hypertrophy, systolic dysfunction and restriction with non-dilated ventricles. Carriers had significant QTc prolongation. The proband presented with resuscitated cardiac arrest. There were 2 transplants. Pathological study of explanted heart demonstrated...



Incessant fascicular VT presenting as cardiogenic shock with multi-organ dysfunction syndrome

Mon, 08 Feb 2016 00:00:00 +0100

We report a rare clinical presentation of incessant idiopathic fascicular ventricular tachycardia (FVT), presenting as multi-organ dysfunction (MOD) syndrome with cardiogenic shock. Our patient was a 19-year-old male who presented with slowly progressive dyspnea from New York Heart Association (NYHA) II to NYHA IV at the time of presentation, palpitations, and dilated cardiomyopathy due to drug-refractory FVT. The patient was in cardiogenic shock with raised central venous pressures and required inotropic support for maintaining systolic blood pressure above 90mmHg. The MOD was seen in the form of deranged liver and kidney parameters. Echocardiography showed a dilated left ventricle (LV, 58mm at end-diastole, 52mm at end-systole) and decreased ejection fraction (20%). Electrocardiography s...



When silence is noise: infantile-onset Barth syndrome caused by a synonymous substitution affecting TAZ gene transcription.

Mon, 08 Feb 2016 00:00:00 +0100

We report a 6 year old boy who presented with severe hypoglycemia, lactic acidosis and severe dilated cardiomyopathy soon after birth. The MLCL:L4-CL ratio confirmed BTHS (3.90 on patient's fibroblast, normal 0-0.3). Subsequent sequencing of the TAZ gene revealed only the new synonymous variant NM_000116.3(TAZ):c.348C>T p.(Gly116Gly), which did not appear to affect the protein sequence. In silico prediction analysis suggested the new c.348C>T nucleotide change could alter the TAZ mRNA splicing processing. We analyzed TAZ mRNAs in the patient's fibroblasts and found an abnormal skipping of 24 bases (NM_000116.3:c.346_371), with the consequent ablation of 8 amino acid residues in the tafazzin protein (NP_000107.1:p.Lys117_Gly124del). Molecular analysis of at risk female family members ...



Clinical Significance of Viral Genome Persistence in the Myocardium of Patients with Dilated Cardiomyopathy

Thu, 04 Feb 2016 21:04:03 +0100

Conclusions: High prevalence of a viral genome in the myocardium of patients with DCM did not have an influence on their long-term clinical outcome.Intervirology 2015;58:350-356 (Source: Intervirology)

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Cardiac fibrosis detected by magnetic resonance imaging on predicting time course diversity of left ventricular reverse remodeling in patients with idiopathic dilated cardiomyopathy

Wed, 03 Feb 2016 00:00:00 +0100

In conclusion, evaluating the presence and the extent of LGE is useful for predicting the clinical differences of LVRR time course and subsequent long-term outcomes. (Source: Heart and Vessels)



Familial lamin A/C Mutation cardiomyopathy with arrhythmia substrate detected by cardiac magnetic resonance imaging and electroanatomical mapping

Wed, 03 Feb 2016 00:00:00 +0100

Lamin proteins A and C are key structural and functional components of the nuclear lamina [1]. Mutations in the lamin A/C gene (LMNA) are associated with a variety of clinical phenotypes, including premature aging, skeletal muscle disease, metabolic disorders and cardiac abnormalities [2]. However, the majority of pathogenic LMNA mutations affect cardiac function, causing atrial fibrillation (AF), conduction disturbances, ventricular arrhythmias, and dilated cardiomyopathy (DCM) [3–7]. (Source: International Journal of Cardiology)



Increased extracellular volume fraction in nonischaemic dilated cardiomyopathy predicts worse outcomes independently of medical therapy

Tue, 02 Feb 2016 06:05:15 +0100

No abstract available (Source: Journal of Cardiovascular Medicine)



Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy

Tue, 02 Feb 2016 06:04:14 +0100

ConclusionsBiallelic truncating mutations in the newly identified gene ALPK3 give rise to severe, early-onset cardiomyopathy in humans. Our findings highlight the importance of transcription factor pathways in the molecular mechanisms underlying human cardiomyopathies. (Source: Journal of the American College of Cardiology)



Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, hybridization and PCR to detect Coxsackievirus B1 in A549 cells

Tue, 02 Feb 2016 00:00:00 +0100

Enterovirus1 (EV) infections are common in all age groups. They are usually asymptomatic or cause only mild respiratory symptoms, but can also lead to more severe illness including hand, foot and mouth disease, myocarditis, meningitis, encephalitis, pancreatitis, systemic infection in newborns and paralysis. EV infections may also play a role in the pathogenesis of chronic diseases such as dilated cardiomyopathy [1], chronic fatigue syndrome [2] and type 1 diabetes2 (T1D) [3–5]. (Source: Journal of Clinical Virology)

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Pathogen-driven treatment strategy in new onset dilated cardiomyopathy. Impact on ventricular function and clinical outcome

Tue, 02 Feb 2016 00:00:00 +0100

Clinical management of new onset dilated cardiomyopathy (NODC) has been an object of intensive research in recent years. Apart from established conventional heart failure, additional therapies remain still under investigation [1]. Such ‘second line’ treatment options include immunomodulatory therapy (namely pathogen-driven therapies – PDT-, intravenous immunoglobulins and immunoadsorption), as well as immunosuppressive therapies namely steroids, azathioprine and cyclosporine A in various combinations [1]. (Source: International Journal of Cardiology)



Assessment of left ventricular hemodynamic forces in healthy subjects and patients with dilated cardiomyopathy using 4D flow MRI

Mon, 01 Feb 2016 00:00:00 +0100

Abstract We hypothesized that the direction of global left ventricular (LV) hemodynamic forces during diastolic filling are concordant with the main flow axes in normal LVs, but that this pattern would be altered in dilated and dysfunctional LVs. Therefore, we aimed to assess the LV hemodynamic filling forces in a group of healthy subjects and compare them to the results from a group of patients with dilated cardiomyopathy (DCM). Ten healthy subjects and 10 DCM patients were enrolled. Morphological short‐ (SAx) and long‐axis (LAx) images and 4D flow MRI data were acquired at 1.5T. The LV pressure gradients were computed from the 4D flow data using the Navier–Stokes equations. By integrating the pressure gradients over the LV volume at each time frame, the magnitude and direction of t...



Intraventricular Isovolumic Relaxation Flow Patterns Studied by Using Vector Flow Mapping

Mon, 01 Feb 2016 00:00:00 +0100

ConclusionsThe IRF pattern is associated with LV function. A large intraventricular vortex persisting during the IVR period should be indicative of increasingly depressed LV function. (Source: Echocardiography)



Generalized pustular psoriasis associated with Turner syndrome and dilated cardiomyopathy

Mon, 01 Feb 2016 00:00:00 +0100

(Source: The Journal of Dermatology)



Arrhythmic Burden and Ambulatory Monitoring of Pediatric Patients with Cardiomyopathy

Mon, 01 Feb 2016 00:00:00 +0100

Conclusions: SCD and device therapies were relatively rare. Routine Holter screening rarely demonstrated significant findings or changed clinical care. Clinical history of ventricular arrhythmia was associated with poor clinical outcome.This article is protected by copyright. All rights reserved (Source: Pacing and Clinical Electrophysiology : PACE)

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Electrical storm in dilated cardiomyopathy treated using epicardial radiofrequency ablation as a first line therapy

Sat, 30 Jan 2016 00:00:00 +0100

We report a patient with non-ischemic dilated cardiomyopathy and low left ventricular systolic function (28%) presenting with an electrical storm originated in epicardial scar and ablated by radiofrequency. This case report suggests that a strategy of epicardial catheter ablation is reasonable for the patient presenting with electrical storm related to structural disease with a low left ventricular ejection fraction. (Source: Indian Heart Journal)



Skeletal Myoblast Cell Sheet Implantation Ameliorates Both Systolic and Diastolic Cardiac Performance in Canine Dilated Cardiomyopathy Model

Fri, 29 Jan 2016 13:05:26 +0100

Conclusions: The potential of SMCST to ameliorate both systolic and diastolic performance was proven. The SMCST may be an alternative therapy of conventional medical treatment in the dilated cardiomyopathy heart. (Source: Transplantation)



Dkk3 prevents familial dilated cardiomyopathy development through Wnt pathway

Wed, 27 Jan 2016 00:00:00 +0100

Authors: Dan Lu, Dan Bao, Wei Dong, Ning Liu, Xu Zhang, Shan Gao, Wenping Ge, Xiang Gao & Lianfeng Zhang (Source: Laboratory Investigation)



Sevoflurane in an infant with dilated cardiomyopathy due to myocarditis and hypocalcaemia

Tue, 26 Jan 2016 00:00:00 +0100

Narendra KumarIndian Journal of Anaesthesia 2016 60(1):73-74 (Source: Indian Journal of Anaesthesia)



Electrophysiologic testing guided risk stratification approach for sudden cardiac death beyond the left ventricular ejection fraction.

Tue, 26 Jan 2016 00:00:00 +0100

Authors: Gatzoulis KA, Tsiachris D, Arsenos P, Tousoulis D Abstract Sudden cardiac death threats ischaemic and dilated cardiomyopathy patients. Anti- arrhythmic protection may be provided to these patients with implanted cardiac defibrillators (ICD), after an efficient risk stratification approach. The proposed risk stratifier of an impaired left ventricular ejection fraction has limited sensitivity meaning that a significant number of victims will remain undetectable by this risk stratification approach because they have a preserved left ventricular systolic function. Current risk stratification strategies focus on combinations of non invasive methods like T wave alternans, late potentials, heart rate turbulence, deceleration capacity and others, with invasive methods like the ele...

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Immunoadsorption therapy for dilated cardiomyopathy using tryptophan column—A prospective, multicenter, randomized, within‐patient and parallel‐group comparative study to evaluate efficacy and safety

Sun, 24 Jan 2016 04:05:04 +0100

The objective of this study was to investigate functional effects of IA therapy using a tryptophan column in severe DCM patients. Of 49 patients enrolled, 44 were randomized from 10 sites in Japan. IA therapy was conducted in 40 patients with DCM (refractory to standard therapy for heart failure, New York Heart Association [NYHA] class III/IV, left ventricular ejection fraction [LVEF] <30%). Mean echocardiographic LVEF was significantly improved (23.8 ± 1.3% to 25.9 ± 1.3%, P = 0.0015). However, mean radionuclide LVEF over 3 months of IA therapy was not significantly improved (20.8 ± 1.1% to 21.9 ± 1%, P = 0.0605). The cardiothoracic ratio was also significantly decreased (P = 0.0010). NYHA functional class (P < 0.0001), subjective symptoms assesse...



Heart acceleration and deceleration capacities associated with dilated cardiomyopathy

Sat, 23 Jan 2016 09:24:03 +0100

ConclusionHeart rate acceleration capacity and deceleration capacity are independent risk factors for DCM, and acceleration capacity is a predictive factor for heart failure exacerbation in DCM patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)



Quantitative criteria for the diagnosis of the congenital absence of pericardium by cardiac magnetic resonance

Fri, 22 Jan 2016 00:00:00 +0100

Conclusions In LCAP the systo-diastolic WHVC was significantly higher than controls, DCM, HCM and RVO patients and resulted an optimal quantitative criteria for the diagnosis of LCAP. (Source: European Journal of Radiology)



Short term omega-3 polyunsaturated fatty acid supplementation induces favorable changes in right ventricle function and diastolic filling pressure in patients with chronic heart failure; A randomized clinical trial.

Fri, 22 Jan 2016 00:00:00 +0100

CONCLUSION: Omega 3-PUFA supplementation was associated with improved left diastolic function and decreased BNP levels in patients with chronic heart failure. These findings suggest a beneficial role of omega 3-PUFAs on the hemodynamic course of patients with systolic heart failure. PMID: 26807502 [PubMed - as supplied by publisher] (Source: Vascular Pharmacology)



Cardiomyopathies: Genetic overlap between peripartum and dilated cardiomyopathies

Fri, 22 Jan 2016 00:00:00 +0100

Nature Reviews Cardiology 13, 121 (2016). doi:10.1038/nrcardio.2016.3 Author: Gregory B. Lim Women with peripartum cardiomyopathy (PPCM) and individuals who develop dilated cardiomyopathy (DCM) might share a genetic predisposition. This finding comes from a gene-sequencing study published in N. Engl. J. Med. in which PPCM was found to be associated with truncating variants in various genes (Source: Nature Reviews Cardiology)

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Impella LD microaxial pump supporting combined mitral and coronary surgery in a patient with dilated cardiomyopathy. A short bridge to recovery?

Wed, 20 Jan 2016 13:34:12 +0100

Authors: Szafron B, Smoczyński RH, Drobiński D, Pawlak A, Wojciechowski D, Liszka IM, Witkowska A, Kaliciński Z, Gil R, Suwalski P Abstract Cardiac surgeons have to face the problem of impaired left ventricle function in patients undergoing routine valve or coronary procedures. The intra-aortic balloon pump is not always effective in preventing cardiac failure. The idea of using a microaxial rotating pump as a short-term perioperative support seems to be a convenient solution. The case of a patient with dilated cardiomyopathy undergoing combined mitral and coronary surgery with elective use of the Impella LD pump is presented. Various options of applying the Impella device are discussed, especially as a bridge to transplant or bridge to recovery. PMID: 26336480 [PubMed] (So...



Parvovirus B19 myocarditis in children: an observational study

Wed, 20 Jan 2016 00:00:00 +0100

Conclusions PVB19 can cause a devastating myocarditis in children. Children with fulminant myocarditis, ST segment changes or a short prodrome have the worst outcome. Transplantation may be considered, but is rarely required in the acute period if mechanical circulatory support is utilised. If the initial presentation is survived, recovery of the myocardium can occur even in those who had fulminant myocarditis. (Source: Archives of Disease in Childhood)



Implantation of the Jarvik 2000® left ventricular assist device using the miniaturized extracorporeal circulation system - a case report.

Wed, 20 Jan 2016 00:00:00 +0100

We report the case of 70-year-old man with congestive dilated cardiomyopathy and bioprosthetic mitral valve who underwent surgical implantation of the Jarvik 2000® LVAD, using the miniaturized extracorporeal circulation (MECC) system.The LVAD was implanted through a left thoracotomy and the MECC system was used to avoid intraoperative spontaneous hemodynamic instability and/or malignant ventricular arrhythmia. The circulatory support with the MECC system was optimal and no complication in terms of hemodynamic instability and perioperative bleeding was recorded. The MECC system obliterated the adverse effects associated with conventional extracorporeal circulation, which are often fatal in critically-ill patients. PMID: 26791274 [PubMed - as supplied by publisher] (Source: Perfusion)



Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human {beta}-cardiac myosin [MECHANISMS OF MUSCLE CONTRACTION AND EXCITATION-CONTRACTION COUPLING]

Wed, 20 Jan 2016 00:00:00 +0100

James A. Spudich, Tural Aksel, Sadie R. Bartholomew, Suman Nag, Masataka Kawana, Elizabeth Choe Yu, Saswata S. Sarkar, Jongmin Sung, Ruth F. Sommese, Shirley Sutton, Carol Cho, Arjun S. Adhikari, Rebecca Taylor, Chao Liu, Darshan Trivedi, and Kathleen M. Ruppel Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease, with a prevalence of more than one in 500 individuals worldwide. Genetically acquired dilated cardiomyopathy is a related disease that is less prevalent. Both are caused by mutations in the genes encoding the fundamental force-generating protein machinery of the cardiac muscle sarcomere, including human β-cardiac myosin, the motor protein that powers ventricular contraction. Despite numerous studies, most performed with non-human or n...



Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells.

Tue, 19 Jan 2016 00:00:00 +0100

Authors: Wehbe M, Huguenin A, Leveque N, Semler BL, Hamze M, Andreoletti L, Bouin A Abstract Coxsackieviruses B (CV-B) (Picornaviridae) are a common infectious cause of acute myocarditis in children and young adults, a disease, which is a precursor to 10-20% of chronic myocarditis and dilated cardiomyopathy (DCM) cases. The mechanisms involved in the disease progression from acute to chronic myocarditis phase and toward the DCM clinical stage are not fully understood but are influenced by both viral and host factors. Subgenomic replicons of CV-B can be used to assess viral replication mechanisms in human cardiac cells and evaluate the effects of potential antiviral drugs on viral replication activities. Our objectives were to generate a reporter replicon from a cardiotropic prototy...

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Recent Patient Characteristics and Medications at Admission and Discharge in Hospitalized Patients With Heart Failure.

Mon, 18 Jan 2016 01:56:03 +0100

CONCLUSIONS: We may be able to improve the clinical outcome of HF by examining the differences in the clinical characteristics and medications at admission and discharge in hospitalized patients with HF. PMID: 26767077 [PubMed] (Source: Clin Med Res)



Titin truncating mutations: A rare cause of dilated cardiomyopathy in the young

Mon, 18 Jan 2016 00:00:00 +0100

Truncating mutations in the TTN gene are the most common genetic cause of dilated cardiomyopathy in adults but their role in young patients is unknown. We studied 82 young dilated cardiomyopathy subjects and found that the prevalence of truncating TTN mutations in adolescents was similar to adults, but surprisingly few truncating TTN mutations were identified in affected children, including one confirmed de novo variant. In several cases, truncating TTN mutations in children with dilated cardiomyopathy had evidence of additional clinical or genetic risk factors. (Source: Progress in Pediatric Cardiology)



Relevance of Truncating Titin Mutations in Dilated Cardiomyopathy.

Mon, 18 Jan 2016 00:00:00 +0100

Authors: Akinrinade O, Alastalo TP, Koskenvuo JW Abstract Dilated cardiomyopathy (DCM), a genetically heterogeneous cardiac disease characterized by left ventricular dilatation and systolic dysfunction, is caused majorly by truncations of titin (TTN), especially in A-band region. Clinical interpretation of TTN truncating variants (TTNtv) has been challenged by the existing inaccurate variant assessment strategies and uncertainty in the true frequency of TTNtv across the general population. We aggregated TTNtv identified in 1788 DCM patients and compared the variants with those reported in the over 60,000 Exome Aggregation Consortium (ExAC) reference population. We implemented our current variant assessment strategy that prioritizes TTNtv affecting all transcripts of the gene, and o...



Echocardiographic evaluation of left ventricular diastolic function in cats: Hemodynamic determinants and pattern recognition

Sat, 16 Jan 2016 00:00:00 +0100

This report will give the reader a summary of the current status in the field of feline diastology with focus on the noninvasive diagnostic methods and interpretation of echocardiographic surrogate measures of LV diastolic function. Lastly, a grading system using a composite of left atrial size and various DE variables potentially useful in the functional classification of LV diastole in cats is introduced. (Source: Journal of Veterinary Cardiology)



Pediatric cardiac transplantation for Non-dilated cardiomyopathies

Sat, 16 Jan 2016 00:00:00 +0100

Cardiomyopathy is the leading diagnosis for pediatric heart transplantation in children over 1year of age. The majority of these patients usually have dilated cardiomyopathy. Children with hypertrophic and restrictive types of cardiomyopathy comprise less than 20% of the total children transplanted. Hypertrophic cardiomyopathy is the smallest subgroup to receive a cardiac transplant (6%). The mean age at listing in the Pediatric Heart Transplant Study (PHTS) was 7.6years, however, 39% were infants listed at a mean of 3.2+2.8months of age. (Source: Progress in Pediatric Cardiology)

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Dietary Nitrate Increased Exercise Tolerance in Patients with Non-Ischemic, Dilated Cardiomyopathy- A Double-Blind, Randomized, Placebo-Controlled, Crossover Trial

Sat, 16 Jan 2016 00:00:00 +0100

Non-ischemic, dilated, cardiomyopathy (NIDCM) is defined as left ventricular dysfunction in the absence of causative coronary artery disease. It typically presents with impaired effort tolerance which is important prognostic factor.1 (Source: The Journal of Heart and Lung Transplantation)



Dietary nitrate increases exercise tolerance in patients with non-ischemic, dilated cardiomyopathy—a double-blind, randomized, placebo-controlled, crossover trial

Sat, 16 Jan 2016 00:00:00 +0100

Non-ischemic dilated cardiomyopathy (NIDCM) is defined as left ventricular dysfunction in the absence of causative coronary artery disease. It typically presents with impaired effort tolerance, which is a major prognostic factor.1 (Source: The Journal of Heart and Lung Transplantation)



Right ventricular dysfunction in patients with idiopathic dilated cardiomyopathy: Prognostic value and predictive factors.

Fri, 15 Jan 2016 00:00:00 +0100

CONCLUSION: In idiopathic dilated cardiomyopathy, RV dysfunction with TAPSE≤15mm offers additional prognostic information, independent of the extent of LV dysfunction. PMID: 26782624 [PubMed - as supplied by publisher] (Source: Archives of Cardiovascular Diseases)



Diagnosis and treatment of cardiac sarcoidosis

Thu, 14 Jan 2016 00:00:00 +0100

Sarcoidosis is a systemic granulomatous disease of unknown aetiology. The frequency of cardiac involvement (cardiac sarcoidosis (CS)) varies in the different geographical regions, but it has been reported that it is an absolutely important prognostic factor in this disease. Complete atrioventricular block is the most common, and ventricular tachycardia/ventricular fibrillation the second most common arrhythmia in this disease, both of which are associated with cardiac sudden death. Diagnosing CS is sometimes difficult because of the non-specific ECG and echocardiographic findings, and CS is sometimes misdiagnosed as dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy or an idiopathic ventricular aneurysm, and therefore, endomyocardial biopsy is important, but has a low ...



Regular cannon wave

Thu, 14 Jan 2016 00:00:00 +0100

Publication date: Available online 14 January 2016 Source:Indian Heart Journal Author(s): Mangalachulli Pottammal Ranjith, Kayakkal Shajudeen, Sankaran Prasanth A 52-year-old male with history of dilated cardiomyopathy was admitted with progressive dizziness and worsening dyspnea. His blood pressure was 100/60 with a regular pulse of 70 per minute. Jugular vein wave showed a prominent pulse like regular cannon waves. Cannon wave occurs in conditions with atrioventricular dissociation and right atrial contraction against a closed tricuspid valve. Large A waves are associated with reduced right ventricular compliance or elevated right ventricular end-diastolic pressure. (Source: Indian Heart Journal)

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Declining Incidence of Systolic Left Ventricular Dysfunction in HIV-Infected Individuals Treated with Highly Active Antiretroviral Therapy

Thu, 14 Jan 2016 00:00:00 +0100

Prior to the highly active antiretroviral therapy (HAART)I era, and currently in countries with limited access to care, up to 38% of adult asymptomatic human immunodeficiency virus (HIV)-infected persons had clinical and echocardiographic evidence of dilated cardiomyopathy associated with lower CD4 counts.1,2 In HIV-infected children, poor nutritional status was also associated with echocardiographic abnormalities that demonstrate decreased left ventricular (LV) systolic dysfunction.3 The pre-HAART era Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection Study (P2C2) looked at longitudinal changes in LV structure and function and mortality in 193 children perinatally infected with HIV enrolled between May 1990 and April 1993. (Source: The American Journal o...



Genetics of CVD in 2015: Using genomic approaches to identify CVD-causing variants

Thu, 14 Jan 2016 00:00:00 +0100

Nature Reviews Cardiology 13, 72 (2016). doi:10.1038/nrcardio.2015.202 Author: Donna K. Arnett Cardiovascular genomics has evolved substantially in the past 2 decades. Numerous papers published in 2015 demonstrate that new genomic approaches, often used synergistically, can yield noteworthy findings. A range of laboratory, analytical, and bioinformatic techniques to uncover genetic contributors to coronary artery disease, myocardial infarction, and dilated cardiomyopathy are described. (Source: Nature Reviews Cardiology)



A substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathy

Thu, 14 Jan 2016 00:00:00 +0100

Familial dilated cardiomyopathy (DCM) is genetically heterogeneous. Mutations in more than 40 genes have been identified in familial cases, mostly inherited in an autosomal dominant pattern. DCM due to recessi... (Source: BMC Medical Genetics)



Declining Incidence of Systolic Left Ventricular Dysfunction in Human Immunodeficiency Virus–Infected Individuals Treated With Highly Active Antiretroviral Therapy

Thu, 14 Jan 2016 00:00:00 +0100

Before the highly active antiretroviral therapy (HAART; it is defined as the concomitant use of ≥3 antiretroviral drugs from at least 2 classes) era and currently in countries with limited access to care, up to 38% of adult asymptomatic human immunodeficiency virus (HIV)–infected people had clinical and echocardiographic evidence of dilated cardiomyopathy associated with lower CD4 counts.1,2 In HIV-infected children, poor nutritional status was also associated with echocardiographic abnormalities that demonstrate decreased left ventricular (LV) systolic dysfunction. (Source: The American Journal of Cardiology)



Depressed Corin Levels Indicate Early Systolic Dysfunction Before Increases of Atrial Natriuretic Peptide/B-Type Natriuretic Peptide and Heart Failure Development [Heart]

Wed, 13 Jan 2016 00:00:00 +0100

Dilated cardiomyopathy is a major cause of heart failure (HF) that affects millions. Corin cleaves and biologically activates pro-atrial natriuretic peptide (pro-ANP) and pro–B-type natriuretic peptide (pro-BNP). High corin levels reduce the development of systolic dysfunction and HF in experimental dilated cardiomyopathy. Yet, patients with significant HF unexpectedly show low corin levels with high plasma ANP/BNP levels. Therefore, we examined the relationship between cardiac corin expression, ANP/BNP levels, and the stages of HF. We used a well-established, dilated cardiomyopathy model to evaluate gene and protein expression as mice longitudinally developed Stages A–D HF. Cardiac systolic function (ejection fraction) continuously declined over time (P<0.001). Cardiac cori...

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Implantable cardioverter-defibrillator elective generator replacement: a procedure for all?

Tue, 12 Jan 2016 00:00:00 +0100

Conclusions Current prediction scores are useful in predicting mortality risk of patients considered for ICD generator replacement and can potentially help identify patients who may not benefit from continuous ICD treatment due to high mortality rates regardless of the ICD. (Source: Journal of Interventional Cardiac Electrophysiology)



Update on Myocarditis and Inflammatory Cardiomyopathy: Reemergence of Endomyocardial Biopsy

Tue, 12 Jan 2016 00:00:00 +0100

Publication date: Available online 12 January 2016 Source:Revista Española de Cardiología (English Edition) Author(s): Fernando Dominguez, Uwe Kühl, Burkert Pieske, Pablo Garcia-Pavia, Carsten Tschöpe Myocarditis is defined as an inflammatory disease of the heart muscle and is an important cause of acute heart failure, sudden death, and dilated cardiomyopathy. Viruses account for most cases of myocarditis or inflammatory cardiomyopathy, which could induce an immune response causing inflammation even when the pathogen has been cleared. Other etiologic agents responsible for myocarditis include drugs, toxic substances, or autoimmune conditions. In the last few years, advances in noninvasive techniques such as cardiac magnetic resonance have been very useful in supporting diagnosis...



Potential heart disorder cause, treatment identified

Mon, 11 Jan 2016 17:13:50 +0100

A novel therapy tested scientists for treating a fatal heart disorder in dogs might ultimately help in diagnosing and treating heart disease in humans. The team also identified potential causes of inherited dilated cardiomyopathy (DCM) or "weak heart." (Source: ScienceDaily Headlines)



FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy

Mon, 11 Jan 2016 00:00:00 +0100

(Source: Genome Biology)



Imaging and 1-day kinetics of intracoronary stem cell transplantation in patients with idiopathic dilated cardiomyopathy

Mon, 11 Jan 2016 00:00:00 +0100

Stem cell transplantation is an emerging method of treatment for patients with cardiovascular disease. There are few studies completed or ongoing on stem cell therapy in patients with idiopathic dilated cardiomyopathy (IDCM). Information on stem cell homing and distribution in the myocardium after transplantation might provide important insight into effectiveness of transplantation procedure.Aimto assess early engraftment, retention and migration of intracoronarily transplanted stem cells in the myocardium of patients with advanced dilated cardiomyopathy of non-ischaemic origin using stem cell labeling with 99mTc-exametazime (HMPAO). (Source: Nuclear Medicine and Biology)

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Tachycardiomyopathy: A case of dilated cardiomyopathy due to permanent junctional reentrant tachycardia

Mon, 11 Jan 2016 00:00:00 +0100

A 43-year-old male patient was admitted to hospital with dyspnoea, edema and atypical chest pain. His weight was 160 kg and he smoked 40 cigarettes per day. (Source: International Journal of Cardiology)



Denervação simpática renal em pacientes com cardiodesfibrilador implantável e tempestade elétrica

Mon, 11 Jan 2016 00:00:00 +0100

Conclusions In patients with ICDs and electrical storm refractory to optimal medical treatment, renal sympathetic denervation significantly reduced arrhythmia load and, consequently, antitachycardia pacing and shocks. Randomized clinical trials in the context of renal sympathetic denervation to control refractory cardiac arrhythmias are needed to further support these findings. (Source: Revista Brasileira de Cardiologia Invasiva)



Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells

Fri, 08 Jan 2016 00:00:00 +0100

This study features the first hiPSC model of RBM20 familial DCM. By monitoring human cardiac disease according to stage-specific cardiogenesis, this study demonstrates RBM20 familial DCM is a developmental disorder initiated by molecular defects that pattern maladaptive cellular mechanisms of pathological cardiac remodeling. Indeed, hiPSC-CMs recapitulate RBM20 familial DCM phenotype in a dish and establish a tool to dissect disease-relevant defects in RBM20 splicing as a global regulator of heart function. (Source: Human Molecular Genetics)



Pheochromocytoma, paraganglioma, Takotsubo syndrome (acute and “chronic”), and catecholamine cardiomyopathies

Fri, 08 Jan 2016 00:00:00 +0100

A recently published review of the association of pheochromocytoma (PHEO) or paraganglioma (PGO) and Takotsubo syndrome (TTS) provides evidence that the above 3 entities and in addition the catecholamine-mediated dilated cardiomyopathy (CC) may be etiologically linked [1]. The authors refer to some patients with catecholamine secreting tumors (PHEO and PGO) who are being asymptomatic, or “may present with multiple and nonspecific symptoms”, and that the “chronic or acute catecholamine intoxication may lead to structural myocardial alterations”, and “result to different types of PHEO-, and PGO-induced cardiomyopathies”, “both chronic and acute, among which is TTS” [1]. (Source: International Journal of Cardiology)