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MedWorm: Cardiology



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in Cardiology



Last Build Date: Mon, 28 Mar 2016 14:37:17 +0100

 



[Castration modalities in prostate cancer: Are they all equal?]

Mon, 28 Mar 2016 12:28:02 +0100

CONCLUSIONS: Recent studies suggest differences between GnRH agonists and antagonist that could impact the patient clinical outcomes. However, further high level of evidence comparative studies remains warranted. PMID: 27017327 [PubMed - as supplied by publisher] (Source: Progres en Urologie)

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Safety assessment of Maillard reaction products of chicken bone hydrolysate using Sprague-Dawley rats.

Mon, 28 Mar 2016 06:45:02 +0100

CONCLUSION: Based on the results of this study, the addition of 9% MRPB in the diet had no adverse effect on both male and female SD rats during the 90-day observation. Those results would provide useful information on the safety of a meaty flavor enhancer from bone residue as a byproduct of meat industry. PMID: 27016175 [PubMed] (Source: Food and Nutrition Research)



A peptide of the RGS domain of GRK2 binds and inhibits Gαq to suppress pathological cardiac hypertrophy and dysfunction.

Mon, 28 Mar 2016 03:05:02 +0100

Authors: Schumacher SM, Gao E, Cohen M, Lieu M, Kurt Chuprun J, Koch WJ Abstract G protein-coupled receptor (GPCR) kinases (GRKs) play a critical role in cardiac function by regulating GPCR activity. GRK2 suppresses GPCR signaling by phosphorylating and desensitizing active GPCRs, and through protein-protein interactions that uncouple GPCRs from their downstream effectors. Several GRK2 interacting partners, including Gαq, promote maladaptive cardiac hypertrophy, which leads to heart failure, a leading cause of mortality worldwide. The regulator of G protein signaling (RGS) domain of GRK2 interacts with and inhibits Gαqin vitro. We generated TgβARKrgs mice with cardiac-specific expression of the RGS domain of GRK2 and subjected these mice to pressure overload to trigger adaptive ...



The effects of assisted cycling therapy (ACT) and voluntary cycling on reaction time and measures of executive function in adolescents with Down syndrome

Sun, 27 Mar 2016 22:00:00 +0100

DiscussionsThese and previous results support the hypothesis of increased neuroplasticity and prefrontal cortex function following ACT and, to a smaller extent, following VC. Both ACT and VC appear to be associated with cortical benefits, but based on current and previous results, ACT seems to maximize the benefits. (Source: Journal of Intellectual Disability Research)



Impact of Iron and Homocysteine Levels on T Peak‐to‐End Interval and Tp‐e/QT Ratio in Elite Athletes

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionThis study showed an independent relationship between iron status and Tp‐e interval and Tp‐e/QT ratios of elite sport players which were also not correlated with serum homocysteine levels. (Source: Annals of Noninvasive Electrocardiology)



Brugada Syndrome Unmasked by Heat Exhaustion

Sun, 27 Mar 2016 22:00:00 +0100

Brugada syndrome (BrS) as an established channelopathy can be unmasked by various triggers like drugs, fever, etc. Herein, we presented a female patient in whom type 1 Brugada pattern on admission electrocardiography might be unmasked by heat exhaustion. (Source: Annals of Noninvasive Electrocardiology)

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Prognostic Value of QRS Fragmentation in Patients with Acute Myocardial Infarction: A Meta‐Analysis

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionPresence of fQRS on admission ECG was found to be predictor of mortality, MACE, deterioration of LV function, and presence of multivessel disease in patients with STEMI and NSTEMI. (Source: Annals of Noninvasive Electrocardiology)



The Role of Transmural Repolarization Gradient in the Inversion of Cardiac Electric Field: Model Study of ECG in Hypothermia

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsThe simulations demonstrated that the transmural repolarization gradient did not play a crucial role in the cardiac electric field inversion under hypothermia, but its magnitude and direction contribute to the T wave amplitude. (Source: Annals of Noninvasive Electrocardiology)



De Winter Electrocardiographic Pattern Related with a Non‐Left Anterior Descending Coronary Artery Occlusion

Sun, 27 Mar 2016 22:00:00 +0100

We present a 53‐year‐old patient with an occlusion of the first diagonal branch and an electrocardiogram showing a “De Winter pattern.” The reported case demonstrates that “De Winter pattern” is not exclusively associated with the occlusion of the proximal segment of the LAD. (Source: Annals of Noninvasive Electrocardiology)



Comparison of Digital 12‐Lead ECG and Digital 12‐Lead Holter ECG Recordings in Healthy Male Subjects: Results from a Randomized, Double‐Blinded, Placebo‐Controlled Clinical Trial

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsThis study suggests that Holter ECGs recorded in a controlled environment are not significantly different but more variable than those from the standard method. (Source: Annals of Noninvasive Electrocardiology)

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Evaluation of Tp‐e Interval, Tp‐e/QT Ratio, and Tp‐e/QTc Ratio in Patients with Asymptomatic Arrhythmogenic Right Ventricular Cardiomyopathy

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionIn conclusion, we have presented strong evidence suggesting that Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio were increased in asymptomatic ARVD patients. (Source: Annals of Noninvasive Electrocardiology)



Electrocardiographic Parameters Indicating Worse Evolution in Patients with Acquired Long QT Syndrome and Torsades de Pointes

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsSome electrocardiographic parameters can be helpful in determining the risk of TdP evolving into VF. The slower ventricular rate (< 220 bpm), the higher rate instability (VRV > 30 ms) and the short episodes < 20 beats could predict benign evolution. (Source: Annals of Noninvasive Electrocardiology)



T‐Wave Alternans, Heart Rate Turbulence, and Ventricular Ectopy in Standard versus Daily Hemodialysis: Results from the FHN Daily Trial

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionsThere were no significant differences in HRT or VE at 1‐year in chronic HD patients randomized to 6x/wk versus 3x/wk and a trend in TWA reduction. Additional studies are needed to evaluate the impact and mechanisms of SCD in HD. (Source: Annals of Noninvasive Electrocardiology)



Issue Information

Sun, 27 Mar 2016 22:00:00 +0100

(Source: Annals of Noninvasive Electrocardiology)



Episodic Left Bundle Branch Block—A Comprehensive Review of the Literature

Sun, 27 Mar 2016 22:00:00 +0100

Episodic (transient/ intermittent) left bundle branch block (LBBB) has been associated with different conditions such as bradycardia, tachycardia, anesthesia, acute pulmonary embolism, changes in intrathoracic pressure, chest trauma, cardiac interventional procedures, mad honey poisoning, and in other clinical settings. Of note, exclusion of an acute coronary syndrome in the setting of episodic LBBB is of great importance. Moreover, episodic LBBB is sometimes symptomatic and may be associated with left ventricular systolic and/or diastolic dysfunction or conduction disturbances leading to syncope. This review article provides a comprehensive overview of the conditions associated with episodic LBBB and discusses the clinical impact of this phenomenon. (Source: Annals of Noninvasive Electroc...



Theories and Controversies on Mechanism of Electrocardiographic Changes during Hemodialysis: Reply to Christov et al.

Sun, 27 Mar 2016 22:00:00 +0100

(Source: Annals of Noninvasive Electrocardiology)

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Review of the 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: What is New and Why?

Sun, 27 Mar 2016 22:00:00 +0100

Abstract In September 2014, the 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes (NSTE-ACS) was released electronically; it was published in print 3 months later, in December 2014. The management of NSTE-ACS has evolved significantly in recent years, and a number of novel agents are now available for use (e.g., prasugrel, ticagrelor). In addition, several key diagnostic and therapeutic agents that were formerly considered hallmarks in the treatment of acute coronary syndrome have fallen out of favor (e.g., glycoprotein inhibitors, CK-MB). The 2014 AHA/ACC NSTE-ACS guideline document is the first comprehensive publication for the treatment of non-ST-elevation acute coronary syndromes since 2007; this review paper serves as an ov...



A comparison of thermal and non-thermal ablation

Sun, 27 Mar 2016 22:00:00 +0100

Publication date: May 2016 Source:Reviews in Vascular Medicine, Volumes 4–5 Author(s): Roshan Bootun, Tristan R.A. Lane, Alun H. Davies Varicose vein disease is common and has an adverse effect on patients. Treatment of the condition has been demonstrated to improve patients' physical well-being and quality of life. Surgical treatment has for a long time been the ‘gold standard’ method until the launch of endovenous thermal ablation towards end of the twentieth century. Indeed, being less invasive and offering the possibility of day-case local anaesthetic procedures, they have gradually become the mainstay of contemporary varicose vein treatment. Vein ablation using steam and microwave are new additions to thermal methods, but there is currently insufficient evidence as to their...



Raynaud phenomenon

Sun, 27 Mar 2016 22:00:00 +0100

Publication date: May 2016 Source:Reviews in Vascular Medicine, Volumes 4–5 Author(s): I. Silva, G. Teixeira, M. Bertão, R. Almeida, A. Mansilha, C. Vasconcelos Raynaud's phenomenon is a common clinical disorder characterized by recurrent vasospasm episodes of digital arteries, arterioles, pre-capillary and post-capillary venules triggered by exposure to cold or emotional stress. RP can be classified as primary (idiopathic), or secondary to several diseases or conditions. The pathogenesis of RP is still not entirely clear or understood, but recent insights into the pathogenic mechanisms underlying Raynaud's phenomenon include vascular, neuronal and intravascular abnormalities which may identify crucial key points and potential targets for therapeutic intervention. In this review...



Factors influencing the success of endovenous laser ablation (EVLA)

Sun, 27 Mar 2016 22:00:00 +0100

Publication date: December 2015 Source:Reviews in Vascular Medicine, Volume 3, Issue 4 Author(s): Giorgio Spreafico, Enrico Bernardi, Patrizia Pavei, Enzo Giraldi (Source: Reviews in Vascular Medicine)

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Common features of atherosclerosis and venous disease

Sun, 27 Mar 2016 22:00:00 +0100

Publication date: December 2015 Source:Reviews in Vascular Medicine, Volume 3, Issue 4 Author(s): Jan Piťha Atherosclerosis and venous diseases exert substantial burden on human population including high prevalence and incidence of mortality and disabling morbidity caused by these disorders. In contrast to the traditional belief, current evidence based on physiological and epidemiological findings indicates that atherosclerotic and venous disease share many common features. Pathophysiological mechanisms underlying both diseases is immune system represented by monocytes/macrophages which interact with endothelial layer of arteries and veins and cause atherosclerotic process and venous insufficiency. From epidemiological point of view, both diseases also share manageable risk factors inc...



Publishers note

Sun, 27 Mar 2016 22:00:00 +0100

Publication date: September 2015 Source:Reviews in Vascular Medicine, Volume 3, Issue 3 (Source: Reviews in Vascular Medicine)



Grief: Two Years and Counting...

Sun, 27 Mar 2016 20:20:21 +0100

I lost my husband Randy to ALS two years ago this week. I have been having a difficult time the last few weeks and I really couldn't put my finger on the reason why. I think about and miss Randy every day but I truly thought I was coming out of the grief haze and on a clear path forward. However, not having experienced this type of grief before, I now realize there is no clear path forward. It's more like an obstacle course. Knowing that I will be living with a hole in my heart for the rest of my life, I had to take some time to figure out my next steps at this point in my journey. Here's what I have come up with: I need to focus on the moments -- today, this moment, right now. Not forgetting Randy, but being present and expressing my love for those who are in my life now. A lot of peop...



Carotid Intima-Media Thickness as the Cardiometabolic Risk Indicator in Patients with Nonfunctional Adrenal Mass and Metabolic Syndrome Screening.

Sun, 27 Mar 2016 17:11:02 +0100

CONCLUSIONS We found that the increased insulin resistance, increased risk of cardiovascular disease with the increase in the thickness of carotid intima-media and diastolic disfunction parameters, although the patients with adrenal incidentaloma are nonfunctional. PMID: 27015815 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)



Comparison of Effects of Separate and Combined Sugammadex and Lipid Emulsion Administration on Hemodynamic Parameters and Survival in a Rat Model of Verapamil Toxicity.

Sun, 27 Mar 2016 17:11:02 +0100

CONCLUSIONS Verapamil overdose is has a comparatively high mortality rate and there is no effective antidote. Treatment generally involves gastric decontamination and symptomatic treatment to counteract the drug's negative effects. In animal studies sugammadex and lipid emulsion had a positive effect on survival in patients with calcium channel blocker toxicity. Sugammadex and intralipid increased survival in a rat model of verapamil toxicity. The combination of both drugs may decrease cardiotoxicity. Sugammadex alone or combined with 20% lipid emulsion reduce the need for inotropic agents. The mechanism requires clarification with larger studies. PMID: 27012816 [PubMed - in process] (Source: Medical Science Monitor)

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Millions of Hispanics at Risk for This Serious Sleep Problem

Sun, 27 Mar 2016 14:46:33 +0100

Did you know that up to 14 percent of Hispanic men and 6 percent of Hispanic women could have obstructive sleep apnea, according to the Hispanic Community Health Study/Study of Latinos? Obstructive sleep apnea is a potentially life-threatening disease involving episodes of complete or partial airway obstruction during sleep. This is bad news, as research shows that sleep apnea is related to increased risk of heart disease, hypertension, Type 2 diabetes and depression. The study also shows that Hispanics in the U.S. with sleep apnea have a 40 percent higher chance of hypertension, a 50 percent higher odds of impaired glucose tolerance and a 90 percent higher risk of diabetes. This is compounded by the high levels of obesity and diabetes already prevalent among Hispanics. While excess body ...



Erratum: Relationship between Right Ventricular Longitudinal Strain, Invasive Hemodynamics, and Functional Assessment in Pulmonary Arterial Hypertension.

Sun, 27 Mar 2016 13:03:02 +0100

Authors: Park JH, Kusunose K, Kwon DH, Park MM, Thomas JD, Grimm RA, Griffin BP, Marwick TH, Popović ZB Abstract [This corrects the article on p. 398 in vol. 45, PMID: 26413108.]. PMID: 27014362 [PubMed] (Source: Korean Circulation Journal)



Red Cell Distribution Width and Coronary Artery Calcification.

Sun, 27 Mar 2016 13:03:02 +0100

Authors: Balta S, Yildirim AO, Ozturk C PMID: 27014361 [PubMed] (Source: Korean Circulation Journal)



The Characteristic Doppler Pattern of the Left Ventricular Outflow Tract in a Patient with Orthostatic Hypotension.

Sun, 27 Mar 2016 13:03:02 +0100

Authors: Shin S, Lee JY, Park JK, Oh S, Jeon DW, Yang JY, Yoon SJ PMID: 27014360 [PubMed] (Source: Korean Circulation Journal)



Complicated Azygos Vein Aneurysm in an Infant Presenting with Acute Pulmonary Thromboembolism.

Sun, 27 Mar 2016 13:03:02 +0100

We present a case where, for the first time, a case of a complicated azygos vein aneurysm was diagnosed in infancy, which required surgical resection. PMID: 27014359 [PubMed] (Source: Korean Circulation Journal)

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Cardiac Metastasis of Leiomyosarcoma Complicated with Complete Atrio-Ventricular Block and Ventricular Tachycardia.

Sun, 27 Mar 2016 13:03:02 +0100

We described a case of a 54-year-old male who presented with dizziness and dyspnea due to cardiac metastasis of leiomyosarcoma. Cardiac metastasis of leiomyosarcoma caused both bradyarrhythmia and tachyarrhythmia in the patient. He was treated with implantation of a permanent pacemaker for management of complete atrio-ventricular block and anti-arrhythmic drug that suppressed ventricular tachycardia successfully. PMID: 27014358 [PubMed] (Source: Korean Circulation Journal)



Spontaneous Bleeding from Internal Pudendal Artery associated with Abciximab after Primary Percutaneous Coronary Intervention: Successful Treatment with Percutaneous Gel-Foam Embolization.

Sun, 27 Mar 2016 13:03:02 +0100

We describe a case of spontaneous bleeding from a branch of the right internal pudendal artery that resulted in massive scrotal swelling in a patient who had underwent primary percutaneous coronary intervention with the use of abciximab concurrent with conventional anticoagulation and dual antiplatelet therapies for the treatment of acute ST-segment elevation myocardial infarction. This unusual complication was promptly identified by percutaneous peripheral arteriography and successfully treated with gel-foam embolization. PMID: 27014357 [PubMed] (Source: Korean Circulation Journal)



Complications of Cardiac Catheterization in Structural Heart Disease.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Currently, the use of cardiac catheterization in SHD is increasing and becoming more complex; this could cause complications despite the preventive efforts. Careful patient selection for therapeutic catheterization and improved technique and management during the peri-procedural period are required to reduce complications. PMID: 27014356 [PubMed] (Source: Korean Circulation Journal)



Assessment of Aortic Elasticity in Patients with Celiac Disease.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Patients with CD had increased aortic stiffness and decreased aortic distensibility. Gluten-free diet enabled the patients with CD to have a reduction in the inflammatory parameters whereas the absence of a significant difference in the elastic properties of the aorta may suggest that the risk of cardiovascular disease persists in this patient group despite a gluten-free diet. PMID: 27014355 [PubMed] (Source: Korean Circulation Journal)

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White Blood Cell Count to Mean Platelet Volume Ratio Is a Prognostic Factor in Patients with Non-ST Elevation Acute Coronary Syndrome with or without Metabolic Syndrome.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Among NSTE-ACS patients without revascularization therapy, elevated admission WMR was associated with an increased risk of developing composite MACE in MetS individuals but not in non-MetS patients. PMID: 27014354 [PubMed] (Source: Korean Circulation Journal)



Valsartan 160 mg/Amlodipine 5 mg Combination Therapy versus Amlodipine 10 mg in Hypertensive Patients with Inadequate Response to Amlodipine 5 mg Monotherapy.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Amlodipine/valsartan 5/160 mg combination was more efficacious than amlodipine 10 mg in hypertensive patients in whom monotherapy of amlodipine 5 mg had failed. PMID: 27014353 [PubMed] (Source: Korean Circulation Journal)



Predicting Left Ventricular Dysfunction after Surgery in Patients with Chronic Mitral Regurgitation: Assessment of Myocardial Deformation by 2-Dimensional Multilayer Speckle Tracking Echocardiography.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: STE can be used to predict a decrease in LV function after MVR in patients with chronic severe MR. This promising method could be of use in the clinic when trying to decide upon the optimum time to schedule surgery for such patients. PMID: 27014352 [PubMed] (Source: Korean Circulation Journal)

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Right Cardiac Catheterization Using the Antecubital Fossa Vein in Korean Patients.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Our study indicated the ease of performance of right cardiac catheterization via the antecubital fossa vein. Thus, the antecubital fossa vein can be an alternative access site for right cardiac catheterization in Korean patients. PMID: 27014351 [PubMed] (Source: Korean Circulation Journal)



Early Parasympathetic Reinnervation Is Not Related to Reconnection of Major Branches of the Vagus Nerve after Heart Transplantation.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Parasympathetic reinnervation seemed to begin in the early period (<1 year) after bicaval HTx. Reconnection of major branches of the vagus nerve may not be related to early reinnervation. PMID: 27014350 [PubMed] (Source: Korean Circulation Journal)



Transvenous Lead Extraction via the Inferior Approach Using a Gooseneck Snare versus Simple Manual Traction.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Transvenous extraction of pacemaker leads via an inferior approach using a gooseneck snare was both safe and effective. However, stand-alone transvenous extraction of defibrillator leads using the inferior approach was suboptimal. PMID: 27014349 [PubMed] (Source: Korean Circulation Journal)

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Tachyarrhythmia Cycle Length in Appropriate versus Inappropriate Defibrillator Shocks in Brugada Syndrome, Early Repolarization Syndrome, or Idiopathic Ventricular Fibrillation.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Programming of a single VF zone of ≤270 ms in patients with BS, ERS, or IVF could reduce inappropriate ICD shocks, with a low risk of missing appropriate shocks. PMID: 27014348 [PubMed] (Source: Korean Circulation Journal)



Psychiatric Characteristics of the Cardiac Outpatients with Chest Pain.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: No differences in psychiatric characteristics were observed between the groups. The intensity of chest pain was linearly associated with somatization without chest pain in the non-CAD group and inversely linearly associated with hypochondriasis in the CAD group. PMID: 27014347 [PubMed] (Source: Korean Circulation Journal)



Numbness after Transradial Cardiac Catheterization: the Results from a Nerve Conduction Study of the Superficial Radial Nerve.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: A transient injury of the superficial radial nerve could be one reason for numbness after a TRC. A large sheath size was an independent predictor of numbness; therefore, large sized sheaths should be used with caution when performing a TRC. PMID: 27014346 [PubMed] (Source: Korean Circulation Journal)

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Prognostic Value of Elevated Homocysteine Levels in Korean Patients with Coronary Artery Disease: A Propensity Score Matched Analysis.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Elevated Hcy level is associated with worse outcomes in Korean patients with CAD. PMID: 27014345 [PubMed] (Source: Korean Circulation Journal)



Rosuvastatin Reduces Blood Viscosity in Patients with Acute Coronary Syndrome.

Sun, 27 Mar 2016 13:03:02 +0100

CONCLUSION: Previous statin medication is an important determinant in lowering WBV in patients with ACS. However, one month of rosuvastatin decreased WBV in statin-naïve ACS patients. PMID: 27014344 [PubMed] (Source: Korean Circulation Journal)



Unsolved Favorable Effect of Statin on Blood Viscosity.

Sun, 27 Mar 2016 13:03:02 +0100

Authors: Shin S PMID: 27014343 [PubMed] (Source: Korean Circulation Journal)



Hypertriglyceridemia and Cardiovascular Diseases: Revisited.

Sun, 27 Mar 2016 13:03:02 +0100

Authors: Han SH, Nicholls SJ, Sakuma I, Zhao D, Koh KK Abstract Residual cardiovascular risk and failure of high density lipoprotein cholesterol raising treatment have refocused interest on targeting hypertriglyceridemia. Hypertriglyceridemia, triglyceride-rich lipoproteins, and remnant cholesterol have demonstrated to be important risk factors for cardiovascular disease; this has been demonstrated in experimental, genetic, and epidemiological studies. Fibrates can reduce cardiovascular event rates with or without statins. High dose omega-3 fatty acids continue to be evaluated and new specialized targeting treatment modulating triglyceride pathways, such as inhibition of apolipoprotein C-III and angiopoietin-like proteins, are being tested with regard to their effects on lipid prof...



Heart Disease in Disorders of Muscle, Neuromuscular Transmission, and the Nerves.

Sun, 27 Mar 2016 13:03:02 +0100

Authors: Finsterer J, Stöllberger C Abstract Little is known regarding cardiac involvement (CI) by neuromuscular disorders (NMDs). The purpose of this review is to summarise and discuss the major findings concerning the types, frequency, and severity of cardiac disorders in NMDs as well as their diagnosis, treatment, and overall outcome. CI in NMDs is characterized by pathologic involvement of the myocardium or cardiac conduction system. Less commonly, additional critical anatomic structures, such as the valves, coronary arteries, endocardium, pericardium, and even the aortic root may be involved. Involvement of the myocardium manifests most frequently as hypertrophic or dilated cardiomyopathy and less frequently as restrictive cardiomyopathy, non-compaction, arrhythmogenic right-...



Continuous "Air" tonometry of the sigmoid colon during abdominal aortic surgery.

Sun, 27 Mar 2016 13:01:01 +0100

CONCLUSIONS: Air tonometry (TONOCAP) is an effective and easily applicable method, allowing the surgeon to be better informed of the tissue oxygenation of the intestinal wall, for the prevention of colon ischemia complications and to take the appropriate measures. PMID: 27015235 [PubMed - as supplied by publisher] (Source: International Angiology)



Microvascular reactivity during sympathetic stimulations in raynaud's phenomenon.

Sun, 27 Mar 2016 13:01:01 +0100

CONCLUSIONS: Abnormal cutaneous microvascular reactivity to central and local axon-reflex sympathetic stimulations was established in RP patients reflecting autoregulatory dysfunctions which might contribute to the manifestations of the ischemic microcirculatory paroxysms. Laser Doppler flowmetry with functional orthostatic and deep breathing tests contribute to the diagnosis of RP. PMID: 27015234 [PubMed - as supplied by publisher] (Source: International Angiology)

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Venous hemodynamic changes in lower limb venous disease: the ULP consensus according to scientific evidence.

Sun, 27 Mar 2016 13:01:01 +0100

Authors: Lee BB, Nicolaides A, Myers K, Meissner M Abstract There are excellent guidelines for clinicians to manage venous diseases but few reviews to assess their hemodynamic background. Hemodynamic concepts that evolved in the past have largely remained unchallenged in recent decades, perhaps due to their often complicated nature and in part due to emergence of new diagnostic techniques. Duplex ultrasound scanning and other imaging techniques which evolved in the latter part of the 20th century have dominated investigation. They have greatly improved our understanding of the anatomical patterns of venous reflux and obstruction. However, they do not provide the physiological basis for understanding the hemodynamics of flow, pressure, compliance and resistance. Hemodynamic investig...



Pseudomonas aeruginosa Infective Endocarditis Following Aortic Valve Implantation: A Note of Caution.

Sun, 27 Mar 2016 13:00:02 +0100

We report a case of PVE due to Pseudomonas aeruginosa after TAVI that required SAVR, with successful outcome. PVE usually occurs during the first year after TAVI and entails a high mortality risk because patients eligible for this min-imally invasive procedure are fragile (i.e. advanced age and/or severe comorbidities). Additionally, clinical presentation may be atypical or subtle and transesophageal echocardiogram (TEE) may not be conclusive, which delays diagnosis and treatment worsening the prognosis. This case highlights that open SAVR might be ultimately indicated as part of treatment for TAVI-PVE despite a high-risk surgery score. PMID: 27014375 [PubMed] (Source: Open Cardiovascular Medicine Journal)



High-altitude Pulmonary Hypertension: an Update on Disease Pathogenesis and Management.

Sun, 27 Mar 2016 13:00:02 +0100

Authors: Mirrakhimov AE, Strohl KP Abstract High-altitude pulmonary hypertension (HAPH) affects individuals residing at altitudes of 2,500 meters and higher. Numerous pathogenic variables play a role in disease inception and progression and include low oxygen concentration in inspired air, vasculopathy, and metabolic abnormalities. Since HAPH affects only some people living at high altitude genetic factors play a significant role in its pathogenesis. The clinical presentation of HAPH is nonspecific and includes fatigue, shortness of breath, cognitive deficits, cough, and in advanced cases hepatosplenomegaly and overt right-sided heart failure. A thorough history is important and should include a search for additional risk factors for lung disease and pulmonary hypertension (PH) suc...

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Long-term Outcome after Percutaneous Coronary Intervention Compared with Minimally Invasive Coronary Artery Bypass Surgery in the Elderly.

Sun, 27 Mar 2016 13:00:02 +0100

CONCLUSION: Among elderly patients, long-term all-cause mortality is similar after PCI and MICS-CABG. However, there is a significantly higher rate of repeat revascularization after PCI. PMID: 27014373 [PubMed] (Source: Open Cardiovascular Medicine Journal)



Testosterone and Cardiovascular Disease.

Sun, 27 Mar 2016 13:00:02 +0100

Authors: Tambo A, Roshan MH, Pace NP Abstract Cardiovascular disease [CVD] is a leading cause of mortality accounting for a global incidence of over 31%. Atherosclerosis is the primary pathophysiology underpinning most types of CVD. Historically, modifiable and non-modifiable risk factors were suggested to precipitate CVD. Recently, epidemiological studies have identified emerging risk factors including hypotestosteronaemia, which have been associated with CVD. Previously considered in the realms of reproductive biology, testosterone is now believed to play a critical role in the cardiovascular system in health and disease. The actions of testosterone as they relate to the cardiac vasculature and its implication in cardiovascular pathology is reviewed. PMID: 27014372 [PubMed] ...



[Effects of lidocaine and magnesium sulfate in attenuating hemodynamic response to tracheal intubation: single-center, prospective, double-blind, randomized study].

Sun, 27 Mar 2016 08:45:02 +0100

CONCLUSION: We concluded that the magnesium sulfate and lidocaine have good efficacy and safety for hemodynamic management in laryngoscopy and intubation. PMID: 27013150 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)



Medical News Today: Digital mammography can help predict heart disease

Sun, 27 Mar 2016 08:00:00 +0100

Digital mammography can detect calcium in the breast arteries that seems to correlate with calcium in the coronary arteries, suggesting a role in detecting heart disease. (Source: Health News from Medical News Today)



Disorder of autonomic nervous system and its vulnerability to external stimulation in functional dyspepsia.

Sun, 27 Mar 2016 07:01:02 +0100

Authors: Tominaga K, Fujikawa Y, Tsumoto C, Kadouchi K, Tanaka F, Kamata N, Yamagami H, Tanigawa T, Watanabe T, Fujiwara Y, Arakawa T Abstract To elucidate the role of autonomic nervous system in functional dyspepsia patients, we examined 24-h heart rate variability: the basal levels, responses after lunch, cold pressor and mental arithmetic tests, and the efficacy of an autonomic drug (tofisopam). The high-frequency component (HF: 0.15-0.40 Hz) and the ratio of HF to the low-frequency component (LF: 0.04-0.15 Hz; LF/HF ratio) were used as indicators of parasympathetic and sympathetic autonomic nervous system function. The HF component in the 24-h, daytime, and nighttime was low in 86.7%, 97.8%, and 66.7% of patients (n = 45) and the LF/HF ratio was high in 51.1%, 73.3%, and 26...



Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression.

Sun, 27 Mar 2016 07:01:02 +0100

Authors: Fei Z, Gao Y, Qiu M, Qi X, Dai Y, Wang S, Quan Z, Liu Y, Ou J Abstract Folic acid supplementation may meliorate cardiovascular disease risk by improving vascular endothelial structure and function. However, the underlying mechanisms are still lack of a global understanding. To be used, folic acid must be converted to 7,8-dihydrofolate by dihydrofolate reductase to generate one-carbon derivatives serving as important cellular cofactors in the synthesis of nucleotides and amino acids required for cell growth. Therefore, this study explored the effect of dihydrofolate reductase knockdown on endothelial EA.hy926 cell growth and the mechanism involved. We found that down-regulation of dihydrofolate reductase inhibited EA.hy926 cell proliferation, and induced G1 phase arrest. Me...



Neutrophil myeloperoxidase and its substrates: formation of specific markers and reactive compounds during inflammation.

Sun, 27 Mar 2016 07:01:02 +0100

Authors: Kato Y Abstract Myeloperoxidase is an inflammatory enzyme that generates reactive hypochlorous acid in the presence of hydrogen peroxide and chloride ion. However, this enzyme also uses bromide ion or thiocyanate as a substrate to form hypobromous or hypothiocyanous acid, respectively. These species play important roles in host defense against the invasion of microorganisms. In contrast, these enzyme products modify biomolecules in hosts during excess inflammation, indicating that the action of myeloperoxidase is both beneficial and harmful. Myeloperoxidase uses other endogenous compounds, such as serotonin, urate, and l-tyrosine, as substrates. This broad-range specificity may have some biological implications. Target molecules of this enzyme and its products vary, includ...

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EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Fang Q, Zou C, Zhong P, Lin F, Li W, Wang L, Zhang Y, Zheng C, Wang Y, Li X, Liang G Abstract Previous studies have implicated inflammation, oxidative stress, and fibrosis as key factors in the development of obesity-induced kidney diseases. Epidermal growth factor receptor (EGFR) plays an important role in cancer development. Recently, the EGFR pathway has been increasingly implicated in chronic cardiovascular diseases via regulating inflammation and oxidative stress. However, it is unclear if EGFR is involved in obesity-related kidney injury. Using ApoE-/- and C57BL/6 mice models and two specific EGFR inhibitors, we investigated the potential effects of EGFR inhibition in the treatment of obesity-related nephropathy and found that EGFR inhibition alleviates renal inflamm...



Pigtail assisted tracking of guide catheter for navigating the difficult radial: Overcoming the “razor effect”

Sat, 26 Mar 2016 23:00:00 +0100

We describe a cost effective and easy technique which overcomes this “razor-blade” effect and helps in tracking the guide catheter in complex radial anatomy for the easy and successful completion of procedure. (Source: Indian Heart Journal)



Factors Associated with Safe Extubation in the Operating Room After On‐Pump Cardiac Valve Surgery

Sat, 26 Mar 2016 23:00:00 +0100

ConclusionsIn select patients, extubation in the OR after on‐pump valve surgery is safe. It is facilitated by shorter duration of CPB and pulmonary perfusion and ventilation during CPB. (Source: Journal of Cardiac Surgery)



Reverse Takotsubo Cardiomyopathy following Exogenous Epinephrine Administration in the Early Postpartum Period

Sat, 26 Mar 2016 23:00:00 +0100

We present a case of reverse TCM in the immediate postpartum period following an injection of local epinephrine, followed by spontaneous resolution within 24 hours. (Source: Echocardiography)

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Partial Posteromedial Papillary Muscle Rupture Caused by Myocardial Ischemia Only without Myocardial Infarction

Sat, 26 Mar 2016 23:00:00 +0100

Mini‐Abstract A 66‐year‐old woman with a history of exertional chest pain was admitted to our hospital. Transthoracic echocardiography displayed an ejection fraction of 71% without regional wall‐motion abnormalities. Transesophageal echocardiography revealed severe mitral regurgitation due to prolapse of P2 scallop with posteromedial papillary muscle (PPM) rupture. Coronary angiography showed 90% stenosis in the left circumflex artery (LCx), and myocardial ischemia without infarction in the lateral wall was observed by means of stress scintigraphy. The surgical inspection and histological finding confirmed diagnosis of P2 scallop prolapse with partial PPM rupture. PPM rupture due to only myocardial ischemia was extremely rare. (Source: Echocardiography)



Siblings with Idiopathic Left Atrial Appendage Ostial Stenosis and Cor Triatriatum

Sat, 26 Mar 2016 23:00:00 +0100

Isolated left atrial appendage (LAA) ostial stenosis is a very rare entity found coincidentally in adults by transesophageal echocardiography. A 3‐month‐old healthy infant was suspected as having cor triatriatum. His brother had a history of surgical treatment of cor triatriatum. A cardiac catheterization revealed a narrowed ostium of the LAA and confirmed the echocardiographic diagnosis of isolated LAA ostial stenosis. This is the first pediatric case of idiopathic LAA ostial stenosis. The siblings called our attention to the differential diagnosis and the etiopathogenesis between LAA ostial stenosis and cor triatriatum. (Source: Echocardiography)



Does Left Ventricular Geometric Patterns Impact Right Atrial Phasic Function? Findings from the Hypertensive Population

Sat, 26 Mar 2016 23:00:00 +0100

ConclusionLeft ventricular geometric patterns have significant impact on RA phasic function in hypertensive patients. Concentric and dilated LVH patterns have the most prominent negative effect on RA morphological and functional remodeling. (Source: Echocardiography)



Muscle biopsies from human muscle diseases with myopathic pathology reveal common alterations in mitochondrial function

Sat, 26 Mar 2016 20:22:37 +0100

This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)

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Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature.

Sat, 26 Mar 2016 19:17:02 +0100

Authors: Cosarderelioglu C, Cosar AM, Gurakar M, Pustavoitau A, Russell SD, Dagher NN, Gurakar A Abstract Portopulmonary hypertension is one of the main pulmonary conditions affecting patients with liver disease and/or portal hypertension. Other conditions include hepatopulmonary syndrome and hepatic hydrothorax. Portopulmonary hypertension is caused by pulmonary vasoconstriction and increased pulmonary vascular resistance. It develops as a result of portal hypertension with or without liver disease and is associated with a higher morbidity and mortality. However, portopulmonary hypertension is usually asymptomatic; the most common symptoms are dyspnea, fatigue, and peripheral edema. All liver transplant candidates should be screened for potential portopulmonary hypertension becaus...



Reliability analysis of the heart autonomic control parameters during hemodialysis sessions.

Sat, 26 Mar 2016 16:39:03 +0100

Authors: da Silva DM, Macedo MC, Lemos LB, Vieira FC, Pirôpo US, Andrade HB, Wessel N, Pereira R Abstract The study of heart autonomic control (HAC) in patients with chronic kidney disease (CKD) undergoing dialysis treatment has been carried out, however, there are no studies reporting the reliability of measurements of HAC parameters involving the mentioned samples and conditions. The reliability of many HAC parameters was evaluated from patients with CKD during two sessions of hemodialysis. The successive R-R intervals were recorded during two sessions of hemodialysis from 14 CKD patients that were undergoing dialysis for at least 6 months and with no history of recurrent hypotensive events. HAC parameters were obtained with time and frequency domain analysis, as well as with no...



6 Amazing Tips for Staying in Shape While Traveling

Sat, 26 Mar 2016 15:48:58 +0100

Staying fit while on the road (and otherwise) is extremely important and somehow I feel that fitness and travel go hand in hand. If you travel a lot , you tend to stay fit and if you are not fit, traveling is just not as much fun, or important anymore -- after all, health always comes first, right? I would like to think of myself as a fit traveler though I am always striving towards harder fitness goals. Staying focused and motivated is the key. As a traveler, any sort of "regular" gym sessions are impossible , however, if you are focused, you can exercise literally anywhere in the world. You don't need a fancy gym and regular classes to keep yourself in shape. People often ask me how I stay fit (modestly isn't my virtue, as you see) and the answer is simple -- I am always "on the move" ...



Value of the neutrophil-to-lymphocyte ratio in predicting post-pericardiotomy syndrome after cardiac surgery.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: The postoperative NLR may be useful to predict the development of PPS in patients undergoing on-pump CABG. PMID: 27010149 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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Effect of TGF-β1/SDF-1/CXCR4 signal on BM-MSCs homing in rat heart of ischemia/perfusion injury.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: TGF-β1 promotes homing of bone marrow (BM) MSCs in I/R injury's myocardial. The study provided useful data on the role of TGF-β1 in regulating SDF-1/CXCR4 axis-induced MSCs homing. PMID: 27010148 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Autonomic Responses to an Acute Bout of High-Intensity Body Weight Resistance Exercise vs. Treadmill Running

Sat, 26 Mar 2016 10:25:17 +0100

Abstract: Kliszczewicz, BM, Esco, MR, Quindry, JC, Blessing, DL, Oliver, GD, Taylor, KJ, and Price, BM. Autonomic responses to an acute bout of high-intensity body weight resistance exercise vs. treadmill running. J Strength Cond Res 30(4): 1050–1058, 2016—The aim of this study was to compare postexercise autonomic nervous system (ANS) recovery between a high-intensity training protocol (HITP) and high-intensity treadmill running (TM) in 10 physically fit males. For each trial, ANS activity was measured through the heart rate variability markers of log-transformed square root of the successive R-R differences (lnRMSSD) and high frequency power (lnHF). These markers were analyzed in 5-minute segments at 5–10 minutes of the pre-exercise period (PRE) and during the postexercise period a...



Physiological and Neuromuscular Response to a Simulated Sprint-Distance Triathlon: Effect of Age Differences and Ability Level

Sat, 26 Mar 2016 10:25:17 +0100

This study aimed to describe the acute impact of a simulated sprint-distance triathlon at physiological and neuromuscular levels and to determine whether age and athletic performance influenced the response in triathletes. Nineteen triathletes performed a sprint-distance triathlon under simulated conditions. Cardiovascular response was monitored during the race. Rate of perceived exertion along with muscular performance parameters (countermovement jump [CMJ], squat jump [SJ], and handgrip strength test [HS]) were tested at pre- and posttest and during every transition, while a 20-m sprint test (S20m) was performed before and after the race. Blood lactate was recorded postrace. A repeated measures analysis of variance showed that the neuromuscular response—in terms of CMJ, SJ, and HS—wa...



Examination of Lifestyle Behaviors and Cardiometabolic Risk Factors in University Students Enrolled in Kinesiology Degree Programs

Sat, 26 Mar 2016 10:25:17 +0100

Abstract: Many, GM, Lutsch, A, Connors, KE, Shearer, J, Brown, HC, Ash, G, Pescatello, LS, Gordish-Dressman, H, Barfield, W, Dubis, G, Houmard, JA, Hoffman, EP, and Hittel, DS. Examination of lifestyle behaviors and cardiometabolic risk factors in university students enrolled in kinesiology degree programs. J Strength Cond Res 30(4): 1137–1146, 2016—Preventing physical inactivity and weight gain during college is critical in decreasing lifelong obesity and associated disease risk. As such, we sought to compare cardiometabolic risk factors and lifestyle behaviors between college students enrolled in kinesiology and non-kinesiology degree programs to assess whether health and exercise degree programs may influence health behaviors and associated disease risk outcomes. Anthropometrics, fa...



Coarctation of the aorta diagnosed by cardiac computed tomography angiography in a 49-year-old man presenting with acute myocardial infarction

Sat, 26 Mar 2016 09:34:19 +0100

We report the case of a 49-year-old man with acute myocardial infarction and diagnosis of severe aortic coarctation in concomitance with a three-dimensional computed tomography scan. (Source: The International Journal of Cardiovascular Imaging)

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Relationship of basal-septal fibrosis with LV outflow tract obstruction in hypertrophic cardiomyopathy: insights from cardiac magnetic resonance analysis

Sat, 26 Mar 2016 09:34:19 +0100

In conclusion, a significant association was observed between LVOT obstruction and basal septal fibrosis by LGE-CMR in HCM patients. In addition to negative impact of basal-septal fibrosis, basal-septal hypertrophy and preserved global LV contractility may be associated with the pathophysiological features of LVOT obstruction. (Source: The International Journal of Cardiovascular Imaging)



Epicardial myocardial strain abnormalities may identify the earliest stages of arrhythmogenic cardiomyopathy

Sat, 26 Mar 2016 09:34:19 +0100

Abstract The aim of this cohort study was to evaluate the value of echocardiographic multilayer strain analysis in the identification of arrhythmogenic cardiomyopathy (AC) in its earliest stages in which sudden cardiac death can occurs. Twenty seven asymptomatic relatives of AC probands (mean age 39.6 ± 19.5 years, 37 % male) with a desmosomal pathogenic mutation but no additional criteria for AC (group II) were compared to age and sex-matched healthy controls (group I). In addition, 70 patients harboring a pathogenic desmosomal mutation with “definitive” diagnosis of AC (group IV), and 19 subjects with “borderline” diagnosis (group III) were also studied. A standard echocardiographic evaluation plus left (LV) and right ventricular global and regional transmural, end...



Are changes in the extent of left ventricular dyssynchrony as assessed by speckle tracking associated with response to cardiac resynchronization therapy?

Sat, 26 Mar 2016 09:34:19 +0100

Abstract Echocardiographic assessment of left ventricular (LV) dyssynchrony is used to predict response to cardiac resynchronization therapy (CRT). However, the association between reduction in the extent of speckle tracking based LV-dyssynchrony and echocardiographic response to CRT has not been explored yet. The aim of this study was to assess the changes in the extent of LV dyssynchrony as a result of CRT and its association with echocardiographic response to CRT in a large consecutive series of patients. We studied 138 patients with standard CRT indication. Time-based speckle tracking longitudinal strain (maximal delay between 6-segments in 4-chamber view) was performed to assess LV-dyssynchrony at baseline and after a mean follow-up of 22 ± 8 months. Echocardiographic CR...



Computed tomography perfusion imaging may predict cognitive impairment in patients with first-time anterior circulation transient ischemic attack

Sat, 26 Mar 2016 09:34:19 +0100

Abstract To determine whether computed tomography perfusion imaging (CTPI)-derived parameters are associated with vascular cognitive impairment (VCI) in patients with transient ischemic attack (TIA). Patients with first-time anterior circulation TIA (diagnosed within 24 h of onset) and normal cognition, treated between August 2009 and August 2014 at the Department of Neurology of Chengdu Military General Hospital, China, were analyzed retrospectively. Patients underwent whole-brain CTPI within 1 week of TIA to detect cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) in the ischemic region. Based on cognitive function assessment 4 weeks after TIA, using the Montreal cognitive assessment (MoCA) and mini mental state examinatio...

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Evaluation for abdominal aortic aneurysms is justified in patients with thoracic aortic aneurysms

Sat, 26 Mar 2016 09:34:19 +0100

Abstract Aortic aneurysms are a significant cause of mortality, and the presence of multiple aneurysms may affect treatment plans. The purpose of this study was to determine the frequency of abdominal aortic aneurysms (AAAs) in patients with thoracic aortic aneurysms (TAAs) and to establish whether patient specific factors, such as gender and comorbidities, influenced the frequency of AAAs, thereby indicating if and when abdominal aortic evaluation is justified. Electronic medical records were reviewed from 1000 patients with a computed tomography (CT) angiogram of the chest and abdomen and a clinical diagnosis of TAA from Cardiac Surgery clinic between 2008 and 2013. 538 patients with history of aortic intervention, dissection, rupture or trauma were excluded. The frequency of A...



18 F-FDG PET/CT in the diagnosis of prosthetic valve endocarditis

Sat, 26 Mar 2016 09:34:19 +0100

Abstract Recent studies have shown promising results using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the diagnosis of prosthetic valve endocarditis (PVE). However, previous studies did not include negative controls. The aim of this study was to compare 18F-FDG-uptake around prosthetic aortic valves in patients with and without PVE and to determine the diagnostic performance of 18F-FDG PET/CT in the diagnosis of PVE. 18F-FDG PET/CT examinations in patients with a prosthetic aortic valve performed 2008–2014 were retrieved. Eight patients with a final diagnosis of definite PVE were included in the analysis of the diagnostic performance of 18F-FDG PET/CT. Examinations performed on suspicion of malignancy in patients without PVE (n ...



The advantages of live/real time three-dimensional transesophageal echocardiography during assessments of pulmonary stenosis

Sat, 26 Mar 2016 09:34:19 +0100

This study provides evidence of the incremental value of using 3D-TEE rather than 2D-TEE during assessments of PS, specifically in cases where special conditions (pregnancy, pulmonary regurgitation, and concomitant atrial septal defects) cause recordings of the transvalvular peak gradient to be inaccurate. Therefore, 3D-TEE should be used as a complementary imaging tool to 2D-TEE during routine echocardiographic examinations. (Source: The International Journal of Cardiovascular Imaging)



Sequential radial and circumferential strain and oxidative stress assessment in dogs with tachycardia-induced cardiac dysfunction

Sat, 26 Mar 2016 09:34:19 +0100

Abstract Quantitative analysis of left ventricular (LV) deformation based on two-dimensional speckle tracking echocardiography (2D STE) has increasingly been used to assess segmental and global function because conventional echocardiography is influenced by tethering effects of adjacent myocardium and cardiac translational motion. Hypothesis: (1) 2D STE can be useful to detect subtle regional changes in the LV contractility during development of tachycardia-induced cardiomyopathy (TIC) to heart failure in awake dog; (2) oxidized glutathione (GSSG) and reduced glutathione (GSH) levels are associated with the development of its respective segmental wall motion abnormalities (WMA). 6 healthy canine female Beagles were examined using 2D STE myocardial strain analysis before and for 8...



Epicardial fat thickness: distribution and association with diabetes mellitus, hypertension and the metabolic syndrome in the ELSA-Brasil study

Sat, 26 Mar 2016 09:34:19 +0100

In conclusion, the amount of EFT in this large multiethnic population is smaller than reported in other populations. EFT reference values varied across demographic and clinical variables, EFT associations with cardiometabolic variables being largely explained by age, sex, ethnicity and central obesity. Although EFT can help identify individuals at increased cardiometabolic risk, it will likely have a limited additional role compared to current risk stratification strategies. (Source: The International Journal of Cardiovascular Imaging)

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Management of Respiratory Failure

Sat, 26 Mar 2016 07:44:23 +0100

The management of acute respiratory failure varies according to the etiology. A clear understanding of physiology of respiration and pathophysiological mechanisms of respiratory failure is mandatory for managing these patients. The extent of abnormality in arterial blood gas values is a result of the balance between the severity of disease and the degree of compensation by cardiopulmonary system. Normal blood gases do not mean that there is an absence of disease because the homeostatic system can compensate. However, an abnormal arterial blood gas value reflects uncompensated disease that might be life threatening. (Source: Critical Care Nursing Quarterly)



Acute Pneumothorax

Sat, 26 Mar 2016 07:44:23 +0100

Pneumothorax is defined as the abnormal presence of air within the pleural space (cavity) that results in the partial or complete collapse of a lung. It can occur spontaneously or due to a traumatic event. Symptoms can vary from a nondescriptive complaint of shortness of breath or chest pain to complete cardiopulmonary collapse. Diagnosis is based on a combination of clinical suspicion along with supporting imaging studies. Treatment often involves surgical or nonsurgical approaches with goal to alleviate symptoms and prevent recurrence. (Source: Critical Care Nursing Quarterly)



More Nurses Mean Fewer Readmissions for Patients With Heart Failure.

Sat, 26 Mar 2016 06:14:02 +0100

Authors: Rosenberg K PMID: 27011143 [PubMed - in process] (Source: The American Journal of Nursing)



Journey of Excellence: Implementing a Shared Decision-Making Model.

Sat, 26 Mar 2016 06:14:02 +0100

Authors: Murray K, Yasso S, Schomburg R, Terhune M, Beidelschies M, Bowers D, Goodyear-Bruch C Abstract : Research has shown that nurses who participate in shared decision making (SDM) have more control over their practice and greater job satisfaction, and hospitals that have instituted SDM have lower rates of nurse turnover and better patient outcomes. The purpose of this article is to describe the implementation of an SDM structure at a pediatric hospital. The hospital's chief nurse officer charged a group of nurses with developing SDM guidelines to outline the purpose, structure, and function of unit councils. A targeted, multifaceted approach to the implementation of these guidelines led to the successful standardization of nine existing unit councils and the expansion of the S...



3 CE Test Hours: Cardiotoxicity and Breast Cancer as Late Effects of Pediatric and Adolescent Hodgkin Lymphoma Treatment.

Sat, 26 Mar 2016 06:14:02 +0100

Authors: Contrada E PMID: 27011135 [PubMed - in process] (Source: The American Journal of Nursing)

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Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3 Expression, a Modulator of Apoptosis and Autophagy.

Sat, 26 Mar 2016 05:16:02 +0100

CONCLUSIONS Puerarin can directly increase BAG3 transcription and translation in cardiomyocytes after A/RI. The elevated BAG3 expression presents protective effects on A/RI at least through enhancing autophagy and reducing apoptosis, which is a novel protective mechanism of puerarin in ARI. PMID: 27011313 [PubMed - in process] (Source: Medical Science Monitor)



Weekend Roundup: Between Engagement and Terror

Sat, 26 Mar 2016 02:39:56 +0100

This week we witnessed a world coming together and a world falling apart, a world between engagement and terror. For the first time in nearly 90 years, an American president visited Cuba, turning upside down the anti-Yanqui narrative that has been the raison d'être of one of the Western Hemisphere's most longest-lasting dictatorships. In Havana, President Barack Obama promised to work toward lifting the embargo on Cuba just as he has done in Iran, where the advance of reformists in last month's election has already demonstrated the fruits of that opening. In Brussels, it appears that some children of Muslim immigrants expressed their explosive alienation in terror attacks in the very city many of them grew up, which also happens to be the capital of Europe. As the French scholar Olivier ...



NOACs No Better Than Warfarin Against Thrombi in Afib (CME/CE)

Sat, 26 Mar 2016 02:35:00 +0100

(MedPage Today) -- Apixaban might be exception, but study lacked power to confirm (Source: MedPage Today Cardiovascular)



The 5 Best Remedies For Sinus Problems

Sat, 26 Mar 2016 01:42:43 +0100

SPECIAL FROM Here’s an appetizing tidbit: Your sinus produces one to two liters of mucus every day—that’s the size of two large soda bottles. Under normal conditions, most of the mucus dribbles undetected down your throat. Yes, it’s gross but also very important: Mucus filters out bacteria, viruses, and fungi in the air that we breathe, and moistens the nasal passages and sinuses, allowing us to breathe easier and lessen risk of infections.  Sometimes, due to allergens, environmental pollution, nasal obstruction or inflammation, the system goes haywire, filling you with congestion. According to American Family Physician, “sinusitis is one of the most common conditions treated by primary care physicians. Each year in the United States, sinusitis affe...

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Test your USMLE Step 2 readiness with this most missed question

Sat, 26 Mar 2016 00:00:00 +0100

If you’re gearing up to take the United States Medical Licensing Examination® (USMLE®) Step 2, this series is for you. Each month, we’re giving you an exclusive scoop on the most missed USMLE Step 2 test prep questions and expert strategies to help you beat them. Check out this month’s most challenging question, and view an expert video explanation of the answer from Kaplan Medical. Think you have what it takes to rise above your peers? Test your USMLE knowledge below. Ready. Set. Go. This month’s question that stumped most students: A 22-year-old African immigrant presents to the hospital with acute abdominal pain. The pain is worst in the left upper quadrant and is described as sharp. She has had this pain for the past several days. She has noticed these episodes frequen...



Breast Calcification on Mammography IDs CVD RiskBreast Calcification on Mammography IDs CVD Risk

Fri, 25 Mar 2016 23:48:24 +0100

Mammography could provide a 'two-fer' for women by identifying breast cancer as well as heart disease, new evidence suggests. Heartwire from Medscape (Source: Medscape Cardiology Headlines)



Robert DeNiro Just Broke My Heart

Fri, 25 Mar 2016 23:31:31 +0100

Robert DeNiro is providing a platform to a dangerous film that misinforms the public about autism and vaccines. (Source: Forbes.com Healthcare News)

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Serum Phosphate modifies the vascular response to vitamin D receptor activation in Chronic Kidney Disease (CKD) patients

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions The beneficial effect of PCT on endothelial function in CKD is maximal in patients with no or minimal changes in phosphate and it is abolished in patients with a pronounced phosphate rise. These findings generate the hypothesis that the endothelium protective effect by VDRA may be potentiated by phosphate lowering interventions. (Source: Nutrition, Metabolism and Cardiovascular Diseases)