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MedWorm: Atrial Fibrillation



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Atrial Fibrillation category.



Last Build Date: Tue, 22 Mar 2016 08:27:40 +0100

 



A New Electrocardiographic Marker of Sudden Death in Brugada Syndrome The S-Wave in Lead I

Tue, 22 Mar 2016 05:43:04 +0100

ConclusionsThe presence of a wide and/or large S-wave in lead I was a powerful predictor of life-threatening ventricular arrhythmias in patients with BrS and no history of cardiac arrest at presentation. However, the prognostic value of a significant S-wave in lead I should be confirmed by larger studies and by an independent confirmation cohort of healthy subjects. (Source: Journal of the American College of Cardiology)

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Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF. (Source: PLoS One)



Dual atrioventricular nodal non-re-entrant tachycardia

Mon, 21 Mar 2016 00:00:00 +0100

(DAVNNT), also known as ‘double fire’, has recently received more attention since it was demonstrated to mimic more common arrhythmias such as atrial premature beats, atrial fibrillation, and ventricular tachycardia. This is important, since mistaken differential diagnoses and the resulting therapeutic decisions have severe consequences for affected patients. DAVNNT is characterized by conduction characteristics of the atrioventricular (AV) node that leads to a double antegrade conduction of one sinoatrial nodal activity via the slow and fast AV nodal pathways. As a result, the most significant hint from an electrocardiogram (ECG) is a P wave followed by two narrow QRS complexes. Although DAVNNT is rather a rare arrhythmia, it now appears to be more common than previously thou...



First clinical trial of specific IKACh blocker shows no reduction in atrial fibrillation burden in patients with paroxysmal atrial fibrillation: pacemaker assessment of BMS 914392 in patients with paroxysmal atrial fibrillation

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion BMS 914932 has not been shown to reduce AF burden in patients with PAF and pacemakers using beat-to-beat pacemaker monitoring throughout the study. BMS 914392 was well tolerated and did not affect QTc or reduce heart rate. Trial registration Clinicaltrials.gov: NCT01356914. (Source: Europace)



Personalized and automated remote monitoring of atrial fibrillation

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion This work demonstrates the ability of a pilot system to classify alerts and improves personalized remote monitoring of patients. In particular, our method allows integration of patient medical history with device alert notifications, which is useful both from medical and resource-management perspectives. The system was able to automatically classify the importance of 1783 AF alerts in 60 patients, which resulted in an 84% reduction in notification workload, while preserving patient safety. (Source: Europace)



The risk of atrial fibrillation during right ventricular pacing

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions HA pacing compared with RVA or RVS pacing seems to be associated with a lower risk of persistent/permanent AF occurrence. The risk of persistent/permanent AF was similar in the RVA vs. RVS groups. (Source: Europace)

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The impact of adjunctive complex fractionated atrial electrogram ablation and linear lesions on outcomes in persistent atrial fibrillation: a meta-analysis

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion In PsAF, the addition of CFAE ablation or LALA, in comparison with PVI alone, offers no significant improvement in arrhythmia-free survival. Furthermore, they are associated with increases in both procedural and fluoroscopy times. The optimal ablation strategy for PsAF is currently unclear and needs further refinement. (Source: Europace)



First-line catheter ablation of paroxysmal atrial fibrillation: outcome of radiofrequency vs. cryoballoon pulmonary vein isolation

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion First-line ablation for PAF is safe and effective with either RF or CB. The procedure was faster with the CB, but the radiation exposure was higher. Although there was a trend for more recurrences and complications in the RF group, a more favourable risk profile in patients undergoing CB ablation might have biased the results. ClinicalTrials.gov identifier NCT01360008. (Source: Europace)



Three-dimensional atrial wall thickness maps to inform catheter ablation procedures for atrial fibrillation

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions Left atrial wall thickness can be measured robustly and efficiently across the whole left atrium using a solution of the Laplace equation over a finite element mesh of the left atrium. Further studies are indicated to determine whether the integration of LAWT maps into pre-existing 3D anatomical mapping systems may provide important anatomical information for guiding radiofrequency ablation. (Source: Europace)



Low P-wave amplitude (

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion Low P-wave amplitude (<0.1 mV) in lead I is related to LA remodelling and displaced inter-atrial conduction pattern to low septum, and independently predicts clinical recurrence after RFCA in patients with PAF. (Source: Europace)



Predictors of left atrial volume index reduction following cryoballoon-based pulmonary vein isolation

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion To the best of our knowledge, this is the largest study in the literature investigating the predictors of LAVIR following AF ablation. According to this data, younger patients without hypertension or moderate MR are most likely to experience LAVIR following ablation. (Source: Europace)

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Differences in predictors of implantable cardioverter-defibrillator therapies in patients with ischaemic and non-ischaemic cardiomyopathies

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion The aetiology of cardiomyopathy should be taken into consideration for the therapy of ICD patients. The protective role of CRT devices should be pointed out in ischaemic cardiomyopathy (ICM) and a more rigorous antiarrhythmic treatment should be considered for ICM patients with secondary prevention or for dilated cardiomyopathy patients with AF. (Source: Europace)



Can we rely on machines? Device-detected atrial high rates correspond well with atrial arrhythmias in cardiac resynchronization recipients

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion Nearly two-thirds of CRT-D patients had AHR episodes within 2.5 years after implantation. Almost 90% of AHRs were indeed AA. Misdetections were caused by far-field sensing or noise. A two-step diagnostic algorithm (>9% of time spent in AHRs and episode duration >36 s) allowed for proper detection of AA with a high hit-rate and specificity. (Source: Europace)



Prevalence of auricular thrombosis before atrial flutter cardioversion: a 17-year transoesophageal echocardiographic study

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion Auricular thrombosis is not an infrequent finding in AFL before CV. Our study suggests the use of TEE screening in AFL, as well as in AF, when patients arrive to clinical attention after more than 48 h from arrhythmia onset. (Source: Europace)



Differences in attitude, education, and knowledge about oral anticoagulation therapy among patients with atrial fibrillation in Europe: result of a self-assessment patient survey conducted by the European Heart Rhythm Association

Mon, 21 Mar 2016 00:00:00 +0100

The purpose of this patient survey was to analyse the knowledge about blood thinning medications relative to gender, age, education, and region of residence in patients with atrial fibrillation (AF). A total of 1147 patients with AF [mean age 66 ± 13 years, 529 (45%) women] from eight European countries responded to this survey. Most patients understood that the indication for anticoagulation therapy was to ‘thin the blood’, but 8.1% responded that the purpose of the medication was to treat the arrhythmia. Patients with college or university grades reported less frequent deviations from their target INR range compared with those without schooling (2.8% vs. 5.1%, P < 0.05). The awareness of anticoagulation-related risk of bleedings was lowest in patients without school...



The acute effects and follow-up after the visually guided laser balloon ablation for atrial fibrillation treatment

Mon, 21 Mar 2016 00:00:00 +0100

(Source: Europace)

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Network meta-analysis of efficacy and safety of competitive oral anticoagulants in patients undergoing radiofrequency catheter ablation of atrial fibrillation

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions The present study suggests that C-VKA is superior to I-VKA for AF patients undergoing RFCA. Rivaroxaban is the highest probability to be the optimal alternative to C-VKA among the three non-VKA oral anticoagulants in AF ablation. (Source: Journal of Interventional Cardiac Electrophysiology)



A clustered randomized trial to IMProve treatment with AntiCoagulanTs in patients with Atrial Fibrillation (IMPACT AF): design and rationale

Mon, 21 Mar 2016 00:00:00 +0100

The objective of this prospective, cluster randomized controlled trial (IMPACT-AF; ClinicalTrials.gov #NCT02082548) is to determine whether a comprehensive customized intervention will increase the rate and persistence of use of OAC in patients with AF. IMPACT-AF will be conducted in approximately 50 centers in 5 low- to middle-income countries. Before randomization, sites within countries will be paired to match in size, practice type and baseline rate of OAC use. Site pairs will be randomized to intervention versus control. In total, 40 to 70 patients with AF and at least 2 CHA2DS2-VASc risk factors will be enrolled at each site using a consecutive enrollment strategy, with the goal of capturing actual practice patterns. We aim for patients with a new diagnosis of AF to comprise at least...



Sex Differences in the Association Between Regular Physical Activity and Incident Atrial Fibrillation: A Meta‐analysis of 13 Prospective Studies

Mon, 21 Mar 2016 00:00:00 +0100

ABSTRACT Several studies investigated the role of physical activity in atrial fibrillation (AF), but the results remain controversial. We aimed to estimate the association between physical activity and incident AF, as well as to determine whether a sex difference existed. We systematically retrieved relevant studies from Cochrane Library, PubMed, and ScienceDirect through December 1, 2015. Data were abstracted from eligible studies and effect estimates pooled using a random‐effects model. Thirteen prospective studies fulfilled inclusion criteria. For primary analysis, neither total physical activity exposure (relative risk [RR]: 0.98, 95% confidence interval [CI]: 0.90‐1.06, P = 0.62) nor intensive physical activity (RR: 1.07, 95% CI: 0.93‐1.25, P = 0.41) was associated with a signif...






Author’s reply to Veloso HH Comment on “The Role of Digitalis Pharmacokinetics in Converting Atrial Fibrillation and Flutter to Sinus Rhythm”

Mon, 21 Mar 2016 00:00:00 +0100

(Source: Clinical Pharmacokinetics)

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Usefulness of CHADS2 and CHA2DS2-VASc scores in the prediction of new-onset atrial fibrillation: a population-based study

Mon, 21 Mar 2016 00:00:00 +0100

CHADS2 and CHA2DS2-VASc are validated scores used to predict stroke in patients with atrial fibrillation. Many of the individual risk factors included in these scores are also risk factors for atrial fibrillation. We aimed to examine the performance of CHADS2 and CHA2DS2-VASc scores in predicting new-onset atrial fibrillation in subjects without preexisting diagnosis of atrial fibrillation. (Source: The American Journal of Medicine)



Clinical relevance of high sensitivity C-reactive protein in cardiology.

Sun, 20 Mar 2016 10:11:01 +0100

Authors: Adukauskienė D, Čiginskienė A, Adukauskaitė A, Pentiokinienė D, Šlapikas R, Čeponienė I Abstract Coping with cardiovascular diseases (CVD), which are of the main causes of death worldwide, has influenced investigation of high sensitivity CRP (hsCRP) and its role in pathogenesis, prognosis and prevention of CVD. hsCRP can be synthesized in vascular endothelium, atherosclerotic plaques, and theory of inflammatory origin of atherosclerosis is being more widely debated, raising questions, whether higher hsCRP plasma concentration might be the cause or the consequence. Summing up controversial data from multiple studies, guidelines recommend hsCRP testing for both, primary (stratifying CVD risk groups, selecting patients for statin therapy) and secondary CVD prevention ...



Device-Detected Atrial Fibrillation—Perils and Pitfalls

Sat, 19 Mar 2016 00:00:00 +0100

This article reviews current literature on the risk of stroke with CIED-detected AHRE and raises questions that need further clarification. (Source: Cardiology Clinics)



The Epidemiology of Atrial Fibrillation and Stroke

Sat, 19 Mar 2016 00:00:00 +0100

The burden of stroke is increasing due to aging population and unhealthy lifestyle habits. The considerable rise in atrial fibrillation (AF) is due to greater diffusion of risk factors and screening programs. The link between AF and ischemic stroke is strong. The subtype most commonly associated with AF is cardioembolic stroke, which is particularly severe and shows the highest rates of mortality and permanent disability. A trend toward a higher prevalence of cardioembolic stroke in high-income countries is probably due to the greater diffusion of AF and the control of atherosclerotic of risk factors. (Source: Cardiology Clinics)



Depression and Physical Inactivity as Confounding the Effect of Obesity on Atrial Fibrillation

Sat, 19 Mar 2016 00:00:00 +0100

Obesity is associated with an increased likelihood for the development of AF and with worsened AF symptom severity. However, other factors that are correlated with obesity may confound or mediate the relationship of obesity with AF symptom severity. The purpose of this study was to determine if depression and physical inactivity may confound the association of obesity and AF symptom severity. Health status and demographic data were captured by questionnaire for 332 outpatients with documented AF. (Source: The American Journal of Cardiology)

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Prolonged Atrial Refractoriness Predicts the Onset of Atrial Fibrillation: A 12 year follow-up study

Sat, 19 Mar 2016 00:00:00 +0100

Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. (Source: Heart Rhythm)



Net clinical benefit of adding aspirin to warfarin in patients with atrial fibrillation: Insights from the J-RHYTHM registry

Sat, 19 Mar 2016 00:00:00 +0100

Concomitant use of vitamin K antagonist (VKA) and aspirin (ASA) is becoming increasingly prevalent among atrial fibrillation (AF) patients. We quantified the net clinical benefit of adding ASA to a VKA using nationwide prospective AF registry data. (Source: International Journal of Cardiology)



Derailed proteostasis as a determinant of cardiac aging

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: Available online 19 March 2016 Source:Canadian Journal of Cardiology Author(s): Marit Wiersma, Robert H. Henning, Bianca J.J.M. Brundel Age comprises the single most important risk factor for cardiac disease development. The incidence and prevalence of cardiac diseases, which represent the main cause of death worldwide, will rise even more due to the aging population. A hallmark of aging is that it is accompanied by a gradual derailment of proteostasis, e.g. the homeostasis of protein synthesis, folding, assembly, trafficking, function and degradation. Loss of proteostasis is highly relevant to cardiomyocytes, as they are post-mitotic cells and therefore not constantly replenished by proliferation. The derailment of proteostasis during aging is thus an important fact...



Dronedarone

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: Available online 19 March 2016 Source:Cardiac Electrophysiology Clinics Author(s): Rafik Tadros, Stanley Nattel, Jason G. AndradeTeaser Dronedarone is the newest antiarrhythmic drug approved for the maintenance of sinus rhythm in patients with nonpermanent atrial fibrillation (AF). It is a multi-channel blocker with diverse electrophysiologic properties. Dronedarone decreases the incidence of AF recurrence and the ventricular rate during recurrence. Dronedarone decreases rates of cardiovascular hospitalizations in patients with paroxysmal and persistent AF. Dronedarone increases mortality in patients with permanent AF and those with moderate-severe heart failure, and should thus be avoided in these populations. Dronedarone is less effective than amiodarone but also h...



Potassium Channel Remodeling in Heart Disease

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: Available online 18 March 2016 Source:Cardiac Electrophysiology Clinics Author(s): Vincent Algalarrondo, Stanley NattelTeaser Heart disease produces substantial remodeling of K+ channels that in general promotes arrhythmia occurrence. In the case of ventricular arrhythmias, K+ channel remodeling contributes to the arrhythmic risk and increases vulnerability to torsades de pointes with K+ channel inhibiting drugs. Atrial K+ channel remodeling caused by atrial fibrillation promotes arrhythmia stability and presents opportunities for the development of new drugs targeting atrial inward rectifier K+ currents. A better understanding of K+ channel remodeling will help clinicians to appreciate arrhythmia mechanisms and determinants in a variety of clinical situations and to ...

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Atrial fibrillation associated with Ibrutinib in Waldenström's macroglobulinemia

Sat, 19 Mar 2016 00:00:00 +0100

(Source: American Journal of Hematology)



Transient postoperative atrial fibrillation after abdominal aortic aneurysm repair increases mortality risk

Sat, 19 Mar 2016 00:00:00 +0100

The purpose of this study was to determine whether new-onset transient postoperative atrial fibrillation (TPAF) affects mortality rates after abdominal aortic aneurysm (AAA) repair and to identify predictors for the development of TPAF. (Source: Journal of Vascular Surgery)



Reversible Atrial Fibrillation with Bradycardia Associated with Primary Cardiac B-Cell Lymphoma.

Fri, 18 Mar 2016 23:15:02 +0100

Authors: Hishikari K, Kuwahara T, Kimura S, Hikita H, Takahashi A, Isobe M Abstract Primary cardiac lymphoma (PCL) only rarely occurs and it is defined as a lymphoma in which the bulk of the tumor is located within the heart and pericardium. A 53-year-old woman was referred due to dyspnea, and an electrocardiogram exhibited atrial fibrillation (AF). Echocardiography revealed no abnormal findings. Scintigraphy and a lymph node biopsy led to a diagnosis of PCL. After the start of chemotherapy, AF was converted to atrial tachycardia prior to sinus rhythm with a first-degree atrioventricular block, which was finally restored to a normal sinus rhythm. PCL is only rarely encountered, but it should be included in the differential diagnosis as a possible cause of AF, and such AF could be r...



Make the Diagnosis: Lower Leg Enigma

Fri, 18 Mar 2016 17:57:37 +0100

(MedPage Today) -- Case Findings: A woman in her nineties presents with sudden changes to her feet, including blisters that were becoming larger and occasionally leaking blood-tinged fluid. The feet were cold to the touch, with no palpable pulses. The patient had a history of atrial fibrillation, and complained of excruciating pain in both feet. What is your diagnosis? (Source: MedPage Today Geriatrics)



Using Discrete Event Simulation to Model the Economic Value of Shorter Procedure Times on EP Lab Efficiency in the VALUE PVI Study.

Fri, 18 Mar 2016 12:10:02 +0100

CONCLUSIONS: The discrete event simulation of the VALUE PVI data demonstrates the potential positive economic value of AF ablation procedures using the cryoballoon. These benefits include more days where overtime is avoided, fewer cumulative overtime hours, and more days with time left for additional usage of EP lab resources. PMID: 26984931 [PubMed - as supplied by publisher] (Source: The Journal of Invasive Cardiology)

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A new approach: Ischemic mitral regurgitation guidelines by and for surgeons

Fri, 18 Mar 2016 09:19:14 +0100

One of the more vexing problems for cardiac surgeons is how best to approach the patient with ischemic mitral regurgitation (IMR). Through the decades, we have been witness to many different surgical concepts, approaches, and especially opinions. We may encounter IMR in patients with advanced heart disease who seem to have no option other than cardiac transplant or ventricular assist device support; we may see IMR in symptom-free patients with an occluded coronary and no other indication for surgery; we may find IMR in patients with angina in the coronary care unit with 3-vessel disease and no previous infarction; or, perhaps most commonly in the surgical population in patients with IMR, we may find IMR associated with a reduced ejection fraction, significant coronary artery disease, atria...



Cellular and Molecular Mechanisms of Arrhythmia by Oxidative Stress.

Fri, 18 Mar 2016 08:59:02 +0100

Authors: Sovari AA Abstract Current therapies for arrhythmia using ion channel blockade, catheter ablation, or an implantable cardioverter defibrillator have limitations, and it is important to search for new antiarrhythmic therapeutic targets. Both atrial fibrillation and heart failure, a condition with increased arrhythmic risk, are associated with excess amount of reactive oxygen species (ROS). There are several possible ways for ROS to induce arrhythmia. ROS can cause focal activity and reentry. ROS alter multiple cardiac ionic currents. ROS promote cardiac fibrosis and impair gap junction function, resulting in reduced myocyte coupling and facilitation of reentry. In order to design effective antioxidant drugs for treatment of arrhythmia, it is essential to explore the molecul...



The Role of Adenosine in Pulmonary Vein Isolation: A Critical Review.

Fri, 18 Mar 2016 08:59:02 +0100

Authors: Dallaglio PD, Betts TR, Ginks M, Bashir Y, Anguera I, Rajappan K Abstract The cornerstone of atrial fibrillation (AF) ablation is pulmonary vein isolation (PVI), which can be achieved in more than 95% of patients at the end of the procedure. However, AF recurrence rates remain high and are related to recovery of PV conduction. Adenosine testing is used to unmask dormant pulmonary vein conduction (DC). The aim of this study is to review the available literature addressing the role of adenosine testing and determine the impact of ablation at sites of PV reconnection on freedom from AF. Adenosine infusion, by restoring the excitability threshold, unmasks reversible injury that could lead to recovery of PV conduction. The studies included in this review suggest that adenosine ...



Percutaneous closure of left atrial appendage for stroke prevention

Fri, 18 Mar 2016 00:00:00 +0100

In conclusion, we need more data and more studies to prove the LAAC principle specifically in the new era of direct oral anticoagulation therapy. (Source: Cor et Vasa)



Myocardial reverse remodeling: how far can we rewind?

Fri, 18 Mar 2016 00:00:00 +0100

Authors: Rodrigues PG, Leite-Moreira AF, Falcão-Pires I Abstract Heart failure (HF) is a systemic disease that can be divided into HF with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). HFpEF accounts for over 50% of all HF patients and is typically associated to high prevalence of several comorbidities, including hypertension, diabetes mellitus, pulmonary hypertension, obesity and atrial fibrillation. Myocardial remodeling occurs both in HFrEF and HFpEF and it involves changes in cardiac structure, myocardial composition, myocyte deformation, and multiple biochemical and molecular alterations that impact heart function and its reserve capacity. Understanding the features of myocardial remodeling has become a major objective for limiting or reversi...

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New Study Seeks to Use Deep Learning to Detect Heart Disease

Thu, 17 Mar 2016 22:22:14 +0100

The developers of Cardiogram, a consumer heart rate-tracking app, have launched a study aiming to use deep learning to detect atrial fibrillation, the most common form of irregular heartbeat. (Source: WSJ.com: Health)



Optimizing Heart Rate and Controlling Symptoms in Atrial Fibrillation

Thu, 17 Mar 2016 11:46:57 +0100

Atrial fibrillation (AF) is the most common pathologic clinical arrhythmia lasting more than 30 seconds, and its incidence and prevalence continue to increase. (Source: Radcliffe Cardiology)



Emerging Strategies for Stroke Prevention in Atrial Fibrillation

Thu, 17 Mar 2016 10:38:39 +0100

It is presumed that the pathogenesis of stroke in atrial fibrillation (AF) patients is due to embolization of thrombus from the left atrium. Within the left atrium, the left atrial appendage is the predominant site of thrombus formation. (Source: Radcliffe Cardiology)



Sinus bradycardia, junctional rhythm, and low-rate atrial fibrillation in Short QT syndrome during 20 years of follow-up: three faces of the same genetic problem

Thu, 17 Mar 2016 04:34:34 +0100

Brief Report Daniela Righi, Massimo S. Silvetti, Fabrizio Drago, Cardiology in the Young, Volume 26 Issue 03, pp 589-592Abstract (Source: Cardiology in the Young)



Preoperative Atrial Fibrillation May Not Increase Thromboembolic Events in Lvad Recipients on Mid-Term Follow-Up

Thu, 17 Mar 2016 00:00:00 +0100

Atrial fibrillation (AF) is a well-established risk factor for thromboembolic (TE) complications. Moreover, AF is frequently found in patients with advanced heart failure including those undergoing left ventricular assist device (LVAD) implantation. However, reports on whether preoperative AF increases the risk of TE events following LVADs are scarce and limited to one or two-center studies. We sought to evaluate the association of preoperative AF with TE events and patient survival using the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). (Source: The Journal of Heart and Lung Transplantation)

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Left Atrial Appendage Occlusion in Non-Valvular Atrial Fibrillation in a Korean Multi-Center Registry.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: LAA occlusion was feasible in non-valvular AF patients with high risk of stroke and hemorrhage. The ACP and Watchman devices were similar in terms of procedural and clinical outcomes. PMID: 26984716 [PubMed - as supplied by publisher] (Source: Circulation Journal)



Asymmetric Dimethylarginine, Related Arginine Derivatives and Incident Atrial Fibrillation

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions ADMA and related arginine derivatives were not associated with incident AF in the community after accounting for other clinical risk factors and confounders. Its role in the pathogenesis of AF needs further refinement. Graphical abstract (Source: American Heart Journal)



Racial and Ethnic Differences in Atrial Fibrillation Risk Factors and Predictors in Women: Findings from the Women’s Health Initiative

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions In this large study of post-menopausal women, traditional cardiovascular risk factors conferred a similar degree of individual risk of AF among four race-ethnic groups. However, major AF risk factors conferred a higher attributable risk in African- Americans and Hispanics compared to NHWs and Asians. (Source: American Heart Journal)



Electrocardiographic Advanced Inter-Atrial Block and Atrial Fibrillation Risk in the General Population

Thu, 17 Mar 2016 00:00:00 +0100

We examined the prevalence, incidence, and prognostic significance of aIAB in 14,625 (mean age=54±5.8 years; 26% black; 55% female) participants from the Atherosclerosis Risk in Communities (ARIC) study. aIAB was detected from digital electrocardiograms recorded during 4 study visits (1987-1989, 1990-1992, 1993-1995, and 1996-1998). (Source: The American Journal of Cardiology)



Medication adherence to rivaroxaban and dabigatran for stroke prevention in patients with non-valvular atrial fibrillation in the United States

Thu, 17 Mar 2016 00:00:00 +0100

The objective of this real-life study was to compare medication adherence to newly-initiated rivaroxaban or dabigatran therapy among NVAF patients in the United States (US). (Source: International Journal of Cardiology)

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Coronary Artery Calcium as an Independent Surrogate Marker in the Risk Assessment of Patients With Atrial Fibrillation and an Intermediate Pretest Likelihood for Coronary Artery Disease Admitted to a German Chest Pain Unit

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionsApart from modified GRACE score, overall correlations between risk scores and calcium burden, as well as revascularization rates during index stay, were low. By contrast, the determination of CS may be used as an additional surrogate marker in risk stratification in AF patients with intermediate pretest likelihood for CAD admitted to a CPU. (Source: Clinical Cardiology)



Ventral cervicothoracic epidural hematoma during anticoagulant therapy and rapid spontaneous resolution

Thu, 17 Mar 2016 00:00:00 +0100

A 71-year-old woman who was undergoing anticoagulant treatment because of atrial fibrillation for a long time was admitted with neck pain and paraparesis of 2 days duration. Magnetic resonance imaging of the cervical and thoracic spine revealed a cervicothoracic ventral epidural hematoma, causing anterior cord compression. The lesion demonstrated mixed signal intensity on T2-weighted images and marked low signal intensity “blooming” on T2-weighted gradient-echo images (Fig. 1). It was iso/hyperintense to cord on T1-weighted images and did not show enhancement on postcontrast images (Fig. (Source: The Spine Journal)



Impact of gout on the risk of atrial fibrillation

Thu, 17 Mar 2016 00:00:00 +0100

Conclusion. This population-based study indicates that gout is independently associated with a higher risk of AF at diagnosis and the risk is also higher after the diagnosis. (Source: Rheumatology)



Many with irregular heartbeat missing out on stroke-preventing treatments

Wed, 16 Mar 2016 16:59:19 +0100

Alan Mozes, HealthDay News Less than half of atrial fibrillation patients at highest risk for stroke are prescribed recommended blood thinners by their cardiologists, new research finds. (Source: Health News - UPI.com)



Many with Irregular Heartbeat Missing Out on Stroke-Preventing Treatments

Wed, 16 Mar 2016 16:00:00 +0100

Less than half at highest risk take recommended blood-thinning medication, study finds Source: HealthDay Related MedlinePlus Pages: Atrial Fibrillation, Blood Thinners, Stroke (Source: MedlinePlus Health News)

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Many With Irregular Heartbeat Missing Out on Stroke-Preventing Treatments

Wed, 16 Mar 2016 12:03:31 +0100

WEDNESDAY, March 16, 2016 -- Doctors know that a heart rhythm disorder called atrial fibrillation increases the odds for stroke. But less than half of "a-fib" patients at highest risk for stroke are prescribed recommended blood thinners by their... (Source: Drugs.com - Daily MedNews)



Effects of Maintaining Body Core Temperature on Atrial Fibrillation

Wed, 16 Mar 2016 00:00:00 +0100

To the Editor: (Source: Journal of Cardiothoracic and Vascular Anesthesia)



EACVI/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillation

Wed, 16 Mar 2016 00:00:00 +0100

Atrial fibrillation (AF) is the commonest cardiac rhythm disorder. Evaluation of patients with AF requires an electrocardiogram, but imaging techniques should be considered for defining management and driving treatment. The present document is an expert consensus from the European Association of Cardiovascular Imaging (EACVI) and the European Heart Rhythm Association. The clinical value of echocardiography, cardiac magnetic resonance (CMR), computed tomography (CT), and nuclear imaging in AF patients are challenged. Left atrial (LA) volume and strain in echocardiography as well as assessment of LA fibrosis in CMR are discussed. The value of CT, especially in planning interventions, is highlighted. Fourteen consensus statements have been reached. These may serve as a guide for both imagers ...



Is Transesophageal Echocardiogram Mandatory in Patients Undergoing Ablation of Atrial Fibrillation With Uninterrupted Novel Oral Anticoagulants? Results From a Prospective Multicenter Registry

Wed, 16 Mar 2016 00:00:00 +0100

Transesophageal echocardiography (TEE) is recommended in patients undergoing atrial fibrillation (AF) ablation, but use of this strategy is variable. (Source: Heart Rhythm)



Comparison of linear versus cubic assessment of left atrial size in the prediction of atrial fibrillation development in hypertrophic cardiomyopathy

Wed, 16 Mar 2016 00:00:00 +0100

Left atrial (LA) enlargement evaluated by echocardiography is a very strong predictor of cardiovascular (CV) outcomes such as atrial fibrillation (AF), stroke, congestive heart failure, and CV death in multiple clinical settings [1,2]. As a consequence, researchers have focused their attention on the best method to assess LA size. Left atrium is a thin-walled cardiac chamber directly exposed to left ventricular (LV) pressure during diastole, which represents its afterload. In particular, in hypertrophic cardiomyopathy (HCM), almost all patients have some degree of LV diastolic dysfunction. (Source: International Journal of Cardiology)

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Guidelines for Potassium Channel Blocker Use

Wed, 16 Mar 2016 00:00:00 +0100

This article summarizes recommendations for the clinical use of antiarrhythmic drugs for the treatment and prevention of atrial and ventricular arrhythmias based on current guideline and consensus documents. The choice of antiarrhythmic drug is based on the efficacy and safety profile and influenced by the presence or absence of structural heart disease. Because of its adverse side-effect profile, amiodarone is recommended for the management of atrial fibrillation only when other agents have failed or are contraindicated. For treatment of symptomatic ventricular arrhythmias in the setting of structural heart disease, amiodarone is generally the preferred agent. (Source: Cardiac Electrophysiology Clinics)



The feasibility of a Box isolation strategy for non-paroxysmal atrial fibrillation in elderly patients

Wed, 16 Mar 2016 00:00:00 +0100

Conclusions Box isolation of non-PAF is effective and safe even in elderly patients. A prophylactic CTI ablation combined with Box isolation might be feasible to improve the long-term outcome. (Source: Journal of Arrhythmia)



Resolution of a warfarin and dabigatran-resistant left atrial appendage thrombus with apixaban

Wed, 16 Mar 2016 00:00:00 +0100

Publication date: Available online 15 March 2016 Source:Journal of Arrhythmia Author(s): Yosuke Miwa, Toshinori Minamishima, Toshiaki Sato, Konomi Sakata, Hideaki Yoshino, Kyoko Soejima The majority of embolisms associated with atrial fibrillation (AF) are from the left atrial appendage (LAA). To treat the existing thrombus, warfarin and novel anticoagulants have been used. However, there has been no clinical information regarding the difference of the effects of congealing the fibrinogenolysis system among these oral anticoagulants. Here, we report a case of persistent AF, in whom apixaban, factor Xa inhibitor resolved an LAA clot refractory to warfarin and direct thrombin inhibition. Factor Xa inhibitor, apixaban, could resolve the left appendage thrombosis refractory to warfarin...



Mortality in Patients With Atrial Fibrillation Randomized to Edoxaban or Warfarin: Insights from the ENGAGE AF-TIMI 48 Trial

Wed, 16 Mar 2016 00:00:00 +0100

When compared with warfarin, edoxaban significantly reduced cardiovascular mortality in the ENGAGE AF-TIMI 48 trial. We studied the possible reasons leading to this reduction. (Source: The American Journal of Medicine)



ECG risk markers for atrial fibrillation and sudden cardiac death in minimally symptomatic obstructive sleep apnoea: the MOSAIC randomised trial

Wed, 16 Mar 2016 00:00:00 +0100

Conclusions There seems to be no effect of CPAP on ECG measures of arrhythmia risk in patients with minimally symptomatic OSA. Trial registration number ISRCTN34164388; Post-results. (Source: BMJ Open)

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Current controversies in determining the main mechanisms of atrial fibrillation

Wed, 16 Mar 2016 00:00:00 +0100

Abstract Despite considerable basic research into the mechanisms of atrial fibrillation (AF), not much progress has been made in the prognosis of patients with AF. With the exception of anticoagulant therapy, current treatments for AF still do not improve major cardiovascular outcomes. This may be due partly to the diverse aetiology of AF with increasingly more factors found to contribute to the arrhythmia. In addition, a strong increase has been seen in the technological complexity of the methods used to quantify the main pathophysiological alterations underlying the initiation and progression of AF. Because of the lack of standardization of the technological approaches currently used, the perception of basic mechanisms of AF varies widely in the scientific community. Areas of debate incl...



Pulmonary vein triggers, focal sources, rotors and atrial cardiomyopathy: implications for the choice of the most effective ablation therapy

Wed, 16 Mar 2016 00:00:00 +0100

Abstract Understanding of the pathophysiological mechanism(s) underlying atrial fibrillation (AF) is the foundation on which current ablation strategies are built. In the vast majority of patients with paroxysmal AF, the ablation procedure should target the pulmonary veins. In patients with nonparoxysmal AF, however, pulmonary vein isolation alone seems to be insufficient to prevent the arrhythmia. Several recent clinical trials have investigated the concept that rotors (re‐entry based on a meandering central core from which spiral waves emanate) might be the mechanism responsible for sustaining AF. Ablation of these localized AF sources is an important step towards substrate‐driven procedures in persistent AF. Hybrid AF ablation procedures, based on the integration of endocardial tran...



Tailored treatment strategies: a new approach for modern management of atrial fibrillation

Wed, 16 Mar 2016 00:00:00 +0100

Abstract Atrial fibrillation (AF) is not benign. Cardiovascular diseases and risk factors differ importantly amongst patients. Careful phenotyping with the aim to start tailored therapy may improve outcome and quality of life. Furthermore, structural remodelling plays an important role in initiation and progression of AF. Therapies that interfere in the remodelling processes are promising because they may modify the atrial substrate. However, success is still limited probably due to variations in the underlying substrate in individual patients. The most favourable effects of lifestyle changes on success of rhythm control have been demonstrated in obese patients with AF. Differences in genotype may also play an important role. Common gene variants have been associated with recurrence of AF ...



Thoracoscopic surgical ablation versus catheter ablation for atrial fibrillation [REVIEWS]

Wed, 16 Mar 2016 00:00:00 +0100

For patients with atrial fibrillation (AF) who are refractory to anti-arrhythmic drugs (AADs), minimally invasive video-assisted thoracoscopic surgical ablation (SA) and catheter ablation (CA) are potential alternative treatment options. The recent FAST randomized study suggested that thoracoscopic SA was superior to CA in achieving freedom of AF in patients who have failed at least one prior AAD. To assess the relative merits and risks of SA versus CA, a systematic review and meta-analysis was conducted. Electronic searches were performed using six databases from their inception to December 2014. Relevant studies comparing thoracoscopic SA and CA were identified; data were extracted and analysed according to predefined clinical endpoints. Relative risk (RR) and weighted mean difference we...



Re: Thoracoscopic surgical ablation versus catheter ablation for atrial fibrillation [REVIEWS]

Wed, 16 Mar 2016 00:00:00 +0100

(Source: European Journal of Cardio-Thoracic Surgery)

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Targeting thrombin long-term after an acute coronary syndrome: opportunities and challenges.

Wed, 16 Mar 2016 00:00:00 +0100

Authors: De Caterina R, Goto S Abstract Patients after an acute coronary syndrome (ACS) are at increased risk of recurrent thrombotic events, justifying the search for additional antithrombotic treatments. The pathophysiology of ACS involves arterial thrombus formation, in turn occurring because of a combination of platelet activation and fibrin formation, with thrombin playing a key role in both. Antiplatelet therapy, targeting the thromboxane pathway and the ADP P2Y12 receptor has been widely accepted for secondary prevention after an ACS. Now, data from recent clinical trials in such patients also encourage the pursuit of inhibiting thrombin formation or thrombin-mediated platelet activation in addition to antiplatelet therapy. This "triple pathway inhibition", including inhibit...



More Research Shows Yoga QOL Benefits for Paroxysmal AFMore Research Shows Yoga QOL Benefits for Paroxysmal AF

Tue, 15 Mar 2016 21:07:37 +0100

"To handle the emotional consequences that comes with atrial fibrillation, patients need practical tools," say experts, noting that yoga complementary to standard treatment can be effective. Heartwire from Medscape (Source: Medscape Medical News Headlines)



Persistent but not Paroxysmal Atrial Fibrillation Is Independently Associated With Lower Cognitive Function ARIC Study

Tue, 15 Mar 2016 16:19:04 +0100

The association of atrial fibrillation (AF) with an increased risk of cognitive impairment or dementia is independent of clinical stroke (1) and may be mediated by subclinical cerebral infarcts (SCIs) (2). However, little is known about whether AF burden (i.e., the percentage of time a person is in AF) is related to cognitive function. Moreover, if such a relationship exists, whether it is mediated by clinical stroke or SCIs is unknown. We hypothesized that a higher AF burden would be independently associated with lower cognitive function after adjustment for clinical stroke but that this association would be attenuated after adjustment for SCIs. We tested our hypothesis in a sample of participants from the U.S. community-based ARIC (Atherosclerosis Risk in Communities) study. (Source: Jou...



Preoperative Laboratory Investigations Rates and Variability Prior to Low-risk Surgical Procedures

Tue, 15 Mar 2016 15:34:16 +0100

Conclusions Results of this study suggest that testing is associated with a range of clinical covariates. However, an association was similarly identified with preoperative consultation, and significant variation between institutions exists across the jurisdiction. (Source: Anesthesiology)



Association Between Baseline Natriuretic Peptides and Atrial Fibrillation Recurrence After Catheter Ablation.

Tue, 15 Mar 2016 13:37:02 +0100

Authors: Zhang Y, Chen A, Song L, Li M, Chen Y, He B Abstract Natriuretic peptides like B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-pro BNP) are reported to be increased in atrial fibrillation (AF) patients. However, the prognostic roles of BNP and NT-pro BNP in post-ablation AF recurrence remain inconclusive. We performed this meta-analysis to investigate the potential role of baseline natriuretic peptides in predicting AF recurrence after catheter ablation.Electronic databases were searched for studies that evaluated the potential relationship between AF recurrence and baseline BNP or NT-pro BNP levels. The pooled standardized mean difference (SMD) and 95% confidence interval (CI) were calculated to quantify differences in BNP or NT-pro BNP levels between patients...

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Left Atrial Remodeling Assessed by Transthoracic Echocardiography Predicts Left Atrial Appendage Flow Velocity in Patients With Paroxysmal Atrial Fibrillation.

Tue, 15 Mar 2016 13:37:02 +0100

Authors: Watanabe A, Suzuki S, Kano H, Matsuno S, Takai H, Kato Y, Otsuka T, Uejima T, Oikawa Y, Nagashima K, Kirigaya H, Kunihara T, Sagara K, Yamashita N, Sawada H, Aizawa T, Yajima J, Yamashita T Abstract Atrial fibrillation (AF) is associated with an increased risk of stroke and other thromboembolic events. Left atrial (LA) thrombus formation is closely related to LA dysfunction, particularly to decreased LA appendage flow velocity (LAA-FV) in patients with AF. We estimated LAA-FV using parameters noninvasively obtained by transthoracic echocardiography (TTE) in patients with paroxysmal AF.Echocardiographic and clinical parameters were assessed in 190 patients with nonvalvular paroxysmal AF showing sinus heart rhythm during transesophageal echocardiography (TEE) and TTE.LAA-FV ...



MRI Mode Programming for Safe Magnetic Resonance Imaging in Patients With a Magnetic Resonance Conditional Cardiac Device.

Tue, 15 Mar 2016 13:37:02 +0100

We describe 2 of the 3 specific cases because they illustrate these potentially risky situations: a case in which the intrinsic heart rate increased and another in which atrial fibrillation occurred. Safe MRI in patients with an MR conditional device necessitates detailed MRI mode programming. The MRI pacing mode should be carefully and individually selected. PMID: 26973263 [PubMed - as supplied by publisher] (Source: International Heart Journal)



The mechanism of mitral regurgitation assessed by preprocedural echocardiography is associated with the outcome of catheter ablation in patients with paroxysmal atrial fibrillation

Tue, 15 Mar 2016 00:00:00 +0100

Conclusion In patients with paroxysmal AF and moderate or severe MR, primary MR may increase the risk of AF recurrence after the initial and final CA. (Source: Journal of Interventional Cardiac Electrophysiology)



Rapport coût/efficacité des traitements médicamenteux et interventionnels dans la fibrillation atriale

Tue, 15 Mar 2016 00:00:00 +0100

Publication date: February 2016 Source:Archives of Cardiovascular Diseases Supplements, Volume 8, Issue 2 Author(s): A. Cohen, C. Leclercq Résumé La fibrillation atriale (FA) est le trouble du rythme le plus fréquent touchant l'adulte âgé et est associée à une augmentation du risque de décès, d'accident ischémique cérébral (AIC), d'insuffisance cardiaque ainsi qu'à une réduction de la qualité de la vie. La charge de cette pathologie sur le patient, les soignants, et donc le retentissement sociétal, est importante. La FA est une maladie chronique augmentant de façon significative le coût de la prise en charge qui peut être lié aux modalités initiales de prise en charge, au traitement des complications, ainsi qu'à la baisse d'activité professionnelle. Cependant, le...



Anticoagulants d'action directe: une revue de la littérature des études coût/efficacité en Europe

Tue, 15 Mar 2016 00:00:00 +0100

Conclusion Les nouveaux traitements présentent des ratios coût/efficacité acceptables en Europe et au Canada, au regard des standards habituels. Au-delà des différences intrinsèques entre les différents systèmes de santé, la diversité des résultats témoigne cependant d'une nécessaire standardisation des études à des fins de comparabilité. Background The cost-effectiveness analysis of therapeutic innovations has become a reference for decision makers in developed countries. When new treatments are available as alternatives to existing well established and cheap treatments, payers anticipate a major budget impact and will assess the extra benefit for society for extra Euros spent. Aims This study aimed at presenting the different published results of cost-effectiveness anal...

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High rate of mortality in Spanish community‐dwelling population aged 85 with atrial fibrillation after three years of follow‐up: The Octabaix study

Tue, 15 Mar 2016 00:00:00 +0100

ConclusionIn oldest old community‐dwelling participants, AF is an independent risk factor for global mortality after a three‐year follow‐up period. (Source: Australasian Journal on Ageing)



Systolic MOLLI T1 mapping with heart-rate-dependent pulse sequence sampling scheme is feasible in patients with atrial fibrillation

Tue, 15 Mar 2016 00:00:00 +0100

T1 mapping enables assessment of myocardial characteristics. As the most common type of arrhythmia, atrial fibrillation (AF) is often accompanied by a variety of cardiac pathologies, whereby the irregular and ... (Source: Journal of Cardiovascular Magnetic Resonance)



The effects of vitamin K supplementation and vitamin K antagonists on progression of vascular calcification: ongoing randomized controlled trials

Tue, 15 Mar 2016 00:00:00 +0100

Conclusion Vitamin K deficiency may be a modifiable cardiovascular risk factor in the haemodialysis population. Conversely, vitamin K antagonists may aggravate VC burden in haemodialysis patients. Several ongoing trials may provide an answer to these questions in the near future. (Source: CKJ: Clinical Kidney Journal)



Response to Letter Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation".

Tue, 15 Mar 2016 00:00:00 +0100

Response to Letter Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation". Circulation. 2016 Mar 15;133(11):e440-1 Authors: Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D PMID: 26976923 [PubMed - in process] (Source: Circulation)



Letter by Olschewski et al Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation".

Tue, 15 Mar 2016 00:00:00 +0100

Letter by Olschewski et al Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation". Circulation. 2016 Mar 15;133(11):e439 Authors: Olschewski A, Chandran N, Olschewski H PMID: 26976922 [PubMed - in process] (Source: Circulation)

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Dabigatran Versus Warfarin for Atrial Fibrillation in Real-World Clinical Practice: A Systematic Review and Meta-Analysis [Original Articles]

Tue, 15 Mar 2016 00:00:00 +0100

Conclusions— In real-world clinical practice, dabigatran is comparable with warfarin in preventing ischemic stroke among patients with nonvalvular atrial fibrillation. However, dabigatran is associated with a lower risk for intracranial bleeding relative to warfarin, but—particularly among the elderly—a greater risk for gastrointestinal bleeding. Bleeding outcomes from observational studies are consistent with those from the pivotal Randomized Evaluation of Long-Term Anticoagulation Therapy trial. (Source: Circulation: Cardiovascular Quality and Outcomes)



Reimagining Anticoagulation Clinics in the Era of Direct Oral Anticoagulants [Cardiovascular Perspective]

Tue, 15 Mar 2016 00:00:00 +0100

Anticoagulation clinics were initially developed to provide safe and effective care for warfarin-treated patients with atrial fibrillation, venous thromboembolism, and mechanical valve replacement. Traditionally, these patients required ongoing laboratory monitoring and warfarin dose adjustment by expert providers. With the introduction of direct oral anticoagulants (dabigatran, rivaroxaban, apixaban, and edoxaban), many have questioned the need for anticoagulation clinic. However, we think that the growing number of oral anticoagulant choices creates an urgent need for expanding the traditional role of the anticoagulation clinic. We outline 3 key purposes that a reimagined anticoagulation clinic would serve: (1) to assist patients and clinicians with selecting the most appropriate drug an...



Loeffler endocarditis: silent right ventricular myocardium!

Tue, 15 Mar 2016 00:00:00 +0100

We present the case of a 54-year-old male patient with Loeffler endocarditis. It is a rare disorder characterized by fibrous thickening of the endocardium leading to apical obliteration and restrictive cardiomyopathy resulting in heart failure, thromboembolic events or atrial fibrillation. To the best of our knowledge, this is the first case reporting the electrical silence of the right ventricular (RV) apex caused by fibrothrombotic thickening of this area. Under these circumstances RV apical implantation of an implantable cardioverter defibrillator (ICD) or pacemaker electrode may lead to unsuccessful stimulation of these devices. PMID: 26980214 [PubMed - as supplied by publisher] (Source: Wiener Klinische Wochenschrift)



[AFNET. A translational research network develops into an academic research organization].

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Kirchhof P, Goette A, Näbauer M, Schotten U Abstract "The whole is greater than the sum of its parts" (Aristotle).Atrial fibrillation (AF) is the most common sustained arrhythmia and affects 1-2 % of the population in developed countries, especially the elderly. We expect that the prevalence of AF will double in the next few decades. The last decades have seen important improvements in the management of atrial fibrillation, but many questions remain regarding the optimal diagnosis and management of the condition. The German Atrial Fibrillation NETwork (AFNET) was one of three cardiovascular competence networks in medicine funded by the German Ministry of Education and Research between 2003-2014. AFNET has contributed to the understanding of atrial fibrillation, and AFNE...



Carotid body modulation in systolic heart failure in the clinical perspective.

Tue, 15 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. PMID: 26990354 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)

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High rate of mortality in Spanish community-dwelling population aged 85 with atrial fibrillation after three years of follow-up: The Octabaix study.

Tue, 15 Mar 2016 00:00:00 +0100

CONCLUSION: In oldest old community-dwelling participants, AF is an independent risk factor for global mortality after a three-year follow-up period. PMID: 26991145 [PubMed - as supplied by publisher] (Source: Australasian Journal on Ageing)



Predictors of reversible severe functional tricuspid regurgitation in patients with atrial fibrillation.

Tue, 15 Mar 2016 00:00:00 +0100

CONCLUSIONS: The improvement of LV systolic function was the only independent predictor of reversible TR. Appropriate medical therapy including management for heart failure should be considered before performing surgery in patients with severe functional TR and AF, especially in patients with LV dysfunction. PMID: 26993263 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)



Biotronik’s BioMonitor 2 hits U.K., Ireland

Mon, 14 Mar 2016 20:44:17 +0100

Biotronik said today it launched its BioMonitor 2 subcutaneous insertable cardiac monitor in the U.K. and Ireland. The BioMonitor 2 device is designed for remote monitoring of patients with atrial fibrillation, syncope, bradycardia and tachychardia, Biotronik said. The device uses Biotronik’s ProMRI technology and is approved for full-body MRI scans at 1.5 and 3 tesla strength. “AF is often so sporadic and unpredictable that it is sometimes impossible to diagnose at the time the patient has symptoms. It is similar with syncope. The patient can hardly choose to faint when they are hooked up to an ECG just so we can find out what’s causing it. But, because BioMonitor 2 is always on and always recording, we can see exactly what’s going on with their cardiac rhythm in these pre...



High false positives found for Medtronic’s implantable AF detectors

Mon, 14 Mar 2016 14:48:09 +0100

LOS ANGELES – Medtronic’s Reveal LINQ implantable loop recorders misidentified 84% of rhythm anomalies as atrial fibrillation in 52 stroke patients at Emory University in Atlanta, according to a... (Source: Internal Medicine News)



Medical News Today: Yoga may ease symptoms for atrial fibrillation patients

Mon, 14 Mar 2016 10:00:00 +0100

A study comparing atrial fibrillation patients who do yoga with patients who do not, shows it may improve quality of life, lower heart rate and lower blood pressure. (Source: Health News from Medical News Today)






Clinical characteristics and outcomes of dialysis patients with atrial fibrillation: the Fushimi AF Registry

Mon, 14 Mar 2016 00:00:00 +0100

Abstract Atrial fibrillation (AF) is common in dialysis patients. However, clinical characteristics and outcomes of dialysis patients with AF are poorly understood. The Fushimi AF Registry is a community-based prospective survey of AF patients in Japan. Follow-up data were available for 3713 patients with a median follow-up of 2.8 years. We compared clinical characteristics and outcomes between the dialysis group (n = 92; 2.5 %) and others. The dialysis group had more various co-morbidities, with a mean CHADS2 score of 2.5, and the rate of warfarin prescription was 38 %. The annual incidence rates of stroke or systemic embolism (SE), major bleeding, and all-cause death in the dialysis group were 4.0, 5.1, and 20.9 per 100 person-years, respectively. There was no significant...



Energy metabolic alterations in the progression of atrial fibrillation: Potential role of AMP-activated protein kinase as a critical regulator

Mon, 14 Mar 2016 00:00:00 +0100

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia associated with increased risk of heart failure and stroke [1]. Accumulating studies have revealed that a series of striking alterations in atrial electrical, structural, and autonomic properties is critical to most acquired forms of AF [2–3]. However, the impact of cardiac energy metabolism upon the initiation or persistence of AF is incompletely understood. Metabolomic and proteomic analyses have indicated a close relationship between metabolic dysfunction and AF development [4]. (Source: International Journal of Cardiology)

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Obesity and Cardiovascular Disease: a Risk Factor or a Risk Marker?

Mon, 14 Mar 2016 00:00:00 +0100

Abstract In the USA, 69 % of adults are either overweight or obese and 35 % are obese. Obesity is associated with an increased incidence of various cardiovascular disorders. Obesity is a risk marker for cardiovascular disease, in that it is associated with a much higher prevalence of comorbidities such as diabetes, hypertension, and metabolic syndrome, which then increase the risk for cardiovascular disease. However, in addition, obesity may also be an independent risk factor for the development of cardiovascular disease. Furthermore, although obesity has been shown to be an independent risk factor for several cardiovascular diseases, it is often associated with improved survival once the diagnosis of the cardiovascular disease has been made, leading to the term “obesity para...