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MedWorm: Arteriosclerosis



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Arteriosclerosis category.



Last Build Date: Tue, 22 Mar 2016 08:28:21 +0100

 



Pulse wave velocity of the leg minus that of the arm measured with a custom device correlates to the coronary calcium quantification

Sun, 20 Mar 2016 00:00:00 +0100

Conclusions For patients without vascular disease, the l-a PWV measured with abiPWV appears to be the index that best correlates with the CCQ. This association is comparable to that between IMT and CCQ and between cfPWV and CCQ. The abiPWV is an easy-to-use device that can help improve vascular risk stratification. (Source: Revista Clinica Espanola)

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Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: NOX1 and NOX2 play differential roles in different platelet activation pathways and in thrombosis. ROS generated by these enzymes promotes platelet activation via the Syk/phospholipase Cγ2/calcium signaling pathway. PMID: 26988594 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Observationally and Genetically High YKL-40 and Risk of Venous Thromboembolism in the General Population: Cohort and Mendelian Randomization Studies.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: High YKL-40 levels were associated with a 2-fold increased risk of venous thromboembolism, but the association was not causal. PMID: 26988593 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



CalDAG-GEFI Deficiency Reduces Atherosclerotic Lesion Development in Mice.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: Our findings suggest that CDGI is critical for atherosclerotic plaque development in hypercholesterolemic Ldlr(-/-) mice because of its contribution to platelet-leukocyte aggregate formation and leukocyte recruitment to the lesion area. PMID: 26988592 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Mesenchymal Stem Cells Attenuate NADPH Oxidase-Dependent High Mobility Group Box 1 Production and Inhibit Abdominal Aortic Aneurysms.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: These results demonstrate that macrophage-produced HMGB1 leads to aortic inflammation and acts as a trigger for CD4(+) T-cell-produced IL-17 during AAA formation. HMGB1 release is dependent on Nox2 activation, which can be inhibited by MSCs leading to attenuation of proinflammatory cytokines, especially IL-17, and protection against AAA formation. PMID: 26988591 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: Notwithstanding the protection afforded by rapamycin in vivo and in vitro, the residual mechanical dysfunctionality suggests a need for caution if rapamycin is to be considered as a potential therapeutic. There is a need for in vivo evaluations in cases of increased hemodynamic loading, including hypertension or extreme exercise, which could unduly stress a structurally vulnerable aortic wall. Given these promising early results, however, such studies are clearly warranted. PMID: 26988590 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Angiotensin II Destabilizes Coronary Plaques in Watanabe Heritable Hyperlipidemic Rabbits.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: These findings suggest that increased blood levels of Ang II can destabilize coronary plaques and trigger the thrombosis, which possibly induces myocardial infarction. The model described in this study provides a novel means for the study of human acute coronary syndrome. PMID: 26988589 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Counterpoint: Low-Density Lipoprotein Cholesterol Targets Are Not Needed in Lipid Treatment Guidelines.

Thu, 17 Mar 2016 00:00:00 +0100

Authors: Robinson JG, Ray K Abstract On the basis of accumulating evidence, low-density lipoprotein cholesterol (LDL-C) treat-to-goal approaches no longer seem to be the best way to optimize lipid-modifying therapy to prevent atherosclerotic cardiovascular disease (ASCVD). The potential for a net ASCVD risk reduction benefit is a more individualized approach to clinical decision making and may better inform patient preferences. However, risk estimation tools will need to be developed to facilitate more personalized CVD risk estimation in statin-treated patients. In the meantime, LDL-C thresholds rather than targets may aid in determining which patients might benefit from additional LDL-C-lowering therapy beyond statins. PMID: 26988588 [PubMed - as supplied by publisher] (Source...



Signaling of Serum Amyloid A Through Receptor for Advanced Glycation End Products as a Possible Mechanism for Uremia-Related Atherosclerosis.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: Uremia upregulates SAA and RAGE expression in the aortic wall and in atherosclerotic lesions in mice. Ager(-/-) animals are protected against the uremia-induced acceleration of atherosclerosis. SAA modulates the functions of murine and human VSMCs in vitro in a RAGE-dependent manner. This study, therefore, identifies SAA as a potential new uremic toxin involved in uremia-related atherosclerosis through interaction with RAGE. PMID: 26988587 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Association of coronary artery calcification with liver fibrosis in Japanese patients with non‐alcoholic fatty liver disease

Tue, 15 Mar 2016 00:00:00 +0100

ConclusionThe progression of arteriosclerosis and that of liver fibrosis may be associated in NAFLD patients. The FIB‐4 index can be easily determined and thus can be a useful marker for predicting cardiovascular events in NAFLD patients. (Source: Hepatology Research)



The High-Density Lipoprotein Puzzle: Why Classic Epidemiology, Genetic Epidemiology, and Clinical Trials Conflict?

Thu, 10 Mar 2016 00:00:00 +0100

Authors: Rosenson R Abstract Classical epidemiology has established the incremental contribution of the high-density lipoprotein (HDL) cholesterol measure in the assessment of atherosclerotic cardiovascular disease risk; yet, genetic epidemiology does not support a causal relationship between HDL cholesterol and the future risk of myocardial infarction. Therapeutic interventions directed toward cholesterol loading of the HDL particle have been based on epidemiological studies that have established HDL cholesterol as a biomarker of atherosclerotic cardiovascular risk. However, therapeutic interventions such as niacin, cholesteryl ester transfer protein inhibitors increase HDL cholesterol in patients treated with statins, but have repeatedly failed to reduce cardiovascular events. St...

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Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: The present study demonstrates a pivotal role for BM-derived calpains in mediating AngII-induced atherosclerosis by influencing macrophage function. PMID: 26966280 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Increases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: ANA treatment increases HDL apoA-I and CETP levels by decreasing the fractional clearance rate of each protein. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00990808. PMID: 26966279 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: Our data demonstrate that glycation can reduce the S1P content of HDL, leading to increased cardiomyocyte cell death because of less effective activation of intracellular survival pathways. It has important implications for the functionality of HDL in diabetes mellitus because HDL-S1P has several beneficial effects on the vasculature. PMID: 26966278 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κβ Pathways.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: Selective deletion of MR in myeloid cells limits macrophage accumulation and vascular inflammation and, therefore, inhibits neointimal hyperplasia and vascular remodeling. Mechanistically, MR deficiency suppresses migration and proliferation of macrophages and leads to less vascular smooth muscle cell activation. At the molecular level, MR deficiency suppresses macrophage inflammatory response via serum-and-glucocorticoid-inducible-kinase-activator protein-1/nuclear factor-κβ pathways. PMID: 26966277 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Modulation of Kinin B2 Receptor Signaling Controls Aortic Dilatation and Rupture in the Angiotensin II-Infused Apolipoprotein E-Deficient Mouse.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: B2R signaling promotes aortic rupture within a mouse model associated with the ability to stimulate inflammatory phenotypes of neutrophils and vascular smooth muscle cells. B2R antagonism could be a potential therapy for AAA. PMID: 26966276 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: Our data-driven integrative genomics framework unraveled tissue-specific relations among the candidate genes of the CAD genome-wide association studies loci and prioritized novel network regulatory genes orchestrating biological processes relevant to CAD. PMID: 26966275 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: The coronary artery disease-associated rs17293632C>T single nucleotide polymorphism represents a novel functional cis-acting element at the SMAD3 locus. The protective (T) allele of rs17293632 disrupts a consensus AP-1 binding site in a SMAD3 intron 1 enhancer, reduces enhancer activity and SMAD3 expression, altering human arterial smooth muscle cells proliferation. PMID: 26966274 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



p.Tyr157Cys Variant in Protease-Activated Receptor 4 Reduces Platelet Functional Responses and Alters Receptor Trafficking.

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSIONS: Reduced PAR4 responses associated with Y157C result from aberrant anterograde surface receptor trafficking, in part, because of disrupted intramolecular hydrogen bonding. Characterization of PAR4 Y157C establishes that rare F2RL3 variants have the potential to markedly alter platelet PAR4 reactivity particularly after exposure to therapeutic PAR1 antagonists. PMID: 26966273 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Comorbidity Analysis According to Sex and Age in Hypertension Patients in China.

Sun, 06 Mar 2016 04:37:02 +0100

CONCLUSIONS: Hypertension patients can be aware of their risks of comorbidities based on our sex-specific results, age-specific patterns, and the comorbidity network. Our findings provide useful insights into the comorbidity prevention, risk assessment, and early warning for hypertension patients. PMID: 26941567 [PubMed - in process] (Source: International Journal of Medical Sciences)



CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo.

Thu, 03 Mar 2016 00:00:00 +0100

CONCLUSIONS: This work yields important information on the efficacy and safety of CRISPR-Cas9 therapy targeting the human PCSK9 gene in human hepatocytes in vivo, and it establishes humanized mice as a useful platform for the preclinical assessment of applications of somatic in vivo genome editing. PMID: 26941020 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Lipoprotein(a) Levels Are Associated With Subclinical Calcific Aortic Valve Disease in White and Black Individuals: The Multi-Ethnic Study of Atherosclerosis.

Thu, 03 Mar 2016 00:00:00 +0100

CONCLUSIONS: Lp(a) cutoff values that are currently used to assess cardiovascular risk seem to be applicable to CAVD, but our results suggest race/ethnicity may be important in cutoff selection. Further studies are warranted to determine whether race/ethnicity influences Lp(a) and risk of CAVD incidence and its progression. PMID: 26941019 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux.

Thu, 03 Mar 2016 00:00:00 +0100

CONCLUSIONS: These studies identify ORP6 as a novel regulator of cholesterol trafficking that is part of the miR-33 and miR-27b target gene networks that contribute to the maintenance of cholesterol homeostasis. PMID: 26941018 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504.

Thu, 03 Mar 2016 00:00:00 +0100

CONCLUSIONS: Diabetes mellitus misregulates several miRNAs including miR-504 that can promote VSMC dysfunction. Because changes in many of these miRNAs are sustained in diabetic VSMC even after in vitro culture, they may be involved in metabolic memory of vascular complications. Targeting such mechanisms could offer novel therapeutic strategies for diabetic complications. PMID: 26941017 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Confirmation of the Intracoronary Near-Infrared Spectroscopy Threshold of Lipid-Rich Plaques That Underlie ST-Segment-Elevation Myocardial Infarction.

Thu, 03 Mar 2016 00:00:00 +0100

CONCLUSIONS: This study substantiates the ability of NIRS to accurately differentiate STEMI culprit from nonculprit segments and confirms that a threshold maxLCBI4mm ≥400 is detected by NIRS in the majority of STEMI culprits. PMID: 26941016 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm.

Thu, 03 Mar 2016 00:00:00 +0100

CONCLUSIONS: Similar to clinical KD, the LCWE-induced KD vasculitis mouse model can also be accompanied by AAA formation. Both IL-1α and IL-1β play a key role, and that use of an IL-1R blocking agent that inhibits both pathways may be a promising therapeutic target not only for KD coronary arteritis, but also for the other systemic arterial aneurysms including AAA that maybe seen in severe cases of KD. The LCWE-induced vasculitis model may also represent an alternative model for AAA disease. PMID: 26941015 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Aberrant DNA methylation in the pathogenesis of atherosclerosis

Wed, 02 Mar 2016 00:00:00 +0100

Publication date: Available online 2 March 2016 Source:Clinica Chimica Acta Author(s): Zhang Hai, Wang Zuo Atherosclerosis, a multifactorial disease of large- and intermediate-sized arteries, is characterized by the accumulation of lipids and the proliferation of arterial smooth muscle cells, chronic inflammatory cells, and fibrous materials. DNA methylation involves inherent and acquired gene transcription changes, which occur independently of the DNA sequence. DNA methylation in the genome plays a major role in the development and progression of atherosclerosis. DNA methylation is a distinct and crucial mechanism that regulates genes governing cell proliferation, thereby linking environmental insults with gene regulation. DNA methyltransferases are crucial in maintaining endothelial ...



Aberrant DNA methylation in the pathogenesis of atherosclerosis.

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Hai Z, Zuo W Abstract Atherosclerosis, a multifactorial disease of large- and intermediate-sized arteries, is characterized by the accumulation of lipids and the proliferation of arterial smooth muscle cells, chronic inflammatory cells, and fibrous materials. DNA methylation involves inherent and acquired gene transcription changes, which occur independently of the DNA sequence. DNA methylation in the genome plays a major role in the development and progression of atherosclerosis. DNA methylation is a distinct and crucial mechanism that regulates genes governing cell proliferation, thereby linking environmental insults with gene regulation. DNA methyltransferases are crucial in maintaining endothelial cell integrity, promoting smooth muscle cell proliferation, and inducing...



Clinical and pathological analyses of interstitial fibrosis and tubular atrophy cases after kidney transplantation

Tue, 01 Mar 2016 00:00:00 +0100

ConclusionsThe results of our study suggests that rejection contributes to IF/TA in 30%‐40% of cases, medullary ray injury in 30%‐40% of cases, and nonspecific injury in 20% of cases. IF/TA contributes significantly to deterioration of renal allograft function. (Source: Nephrology)



Correction.

Sat, 27 Feb 2016 06:34:11 +0100

Authors: PMID: 26912745 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Bidirectional Translation in Cardiovascular Calcification.

Sat, 27 Feb 2016 06:34:11 +0100

Authors: St Hilaire C, Liberman M, Miller JD, Early Career Committee PMID: 26912744 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Simultaneous Platelet P2Y12 and P2Y1 ADP Receptor Blockade: Are Two Better Than One?

Sat, 27 Feb 2016 06:34:11 +0100

Authors: Vaduganathan M, Bhatt DL PMID: 26912743 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



The Clot Thickens in Atherosclerosis.

Sat, 27 Feb 2016 06:34:11 +0100

Authors: Mackman N PMID: 26912742 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Estimating the extent of subclinical arteriosclerosis of persons with prediabetes and diabetes mellitus among Japanese urban workers and their families: a cross-sectional study

Wed, 24 Feb 2016 00:00:00 +0100

Diabetes mellitus (hereafter called diabetes) is considered to accelerate arteriosclerosis leading to coronary heart disease and stroke. Thus, it is important to quantitatively estimate the extent of subclinic... (Source: BMC Cardiovascular Disorders)



Late Failing Heart AllograftsLate Failing Heart Allografts

Tue, 23 Feb 2016 05:59:36 +0100

Learn more about the role of antibody-mediated rejection and coronary arteriosclerosis in late failing heart allografts. American Journal of Transplantation (Source: Medscape Transplantation Headlines)



Lipoprotein binding to anionic biopolyelectrolytes and the effect of glucose on nanoplaque formation in arteriosclerosis and Alzheimer's disease.

Fri, 19 Feb 2016 00:00:00 +0100

We described extensively molecular composition, conformation, form and function of the macromolecule heparan sulfate proteoglycan (HS-PG). In two supplementary experimental settings (ellipsometry, myography), we utilized isolated HS-PG for in vitro nanoplaque investigations and isolated human coronary artery segments for in vivo tension measurements. With the ellipsometry-based approach, we were successful in establishing a direct connection on a molecular level between diabetes mellitus on the one side and arteriosclerosis/Alzheimer's disease on the other side. Application of glucose at a concentration representative for diabetics and leading to glycation of proteins and lipids, entailed a significant increase in arteriosclerotic and Alzheimer nanoplaque formation. IDLapoE4/E4 was by far ...

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Loss of Thrombomodulin in Placental Dysfunction in Preeclampsia.

Thu, 18 Feb 2016 00:00:00 +0100

CONCLUSIONS: Decreased thrombomodulin expression in preeclampsia may play a role in placental dysfunction in preeclampsia and is possibly caused by an angiogenic imbalance. Hypertension and obesity are associated with thrombomodulin downregulation. These results set the stage for further basic and clinical research on thrombomodulin in the pathogenesis of preeclampsia and other syndromes characterized by endothelial dysfunction. PMID: 26891741 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: Formation, Progression, and the Role of Focal Dissections.

Thu, 18 Feb 2016 00:00:00 +0100

CONCLUSIONS: We visualized and quantified the dissections that lead to ascending aortic aneurysms in angiotensin II-infused mice and provided unique insight into the temporal evolution of these lesions. PMID: 26891740 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness With Aging in Primates.

Thu, 18 Feb 2016 00:00:00 +0100

CONCLUSIONS: Thus, aortic stiffness increases with aging as expected, but the most severe increases in aortic stiffness observed in the abdominal aorta is novel, where values in young monkeys equaled, or even exceeded, values of thoracic aortic stiffness in old monkeys. These results can be explained by alterations in collagen/elastin ratio, but even more importantly by collagen and elastin disarray. PMID: 26891739 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Relationship Between Lymphedema and Arteriosclerosis: Higher Cardio-Ankle Vascular Index (CAVI) in Lymphedematous Limbs

Wed, 17 Feb 2016 18:07:10 +0100

Background: Arteriosclerosis is one of the most important public health issues because it is very common in developed countries and its sequelae are lethal. Lymphatic vessel insufficiency has been reported to be associated with atherogenesis. Lymphedema seems to affect progression of arteriosclerosis, but no clinical study has been reported. Methods: Forty-eight limbs of 24 female patients with pelvic cancer-related lower extremity lymphedema (LEL) were evaluated. Cardio-ankle vascular index (CAVI), an indirect estimate of the arterial stiffness, was measured in each limb. Cardio-ankle vascular index was compared according to known arteriosclerosis risk factors including age (younger than 65 years vs 65 years), body mass index (BMI; (Source: Annals of Plastic Surgery)



Asthma Diagnosis Tied to Higher Risk for Abdominal Aortic Aneurysm Rupture (FREE)

Fri, 12 Feb 2016 00:00:00 +0100

By Kelly Young Edited by André Sofair, MD, MPH, and William E. Chavey, MD, MS A recent diagnosis of asthma is associated with higher risk for rupture in older patients with abdominal aortic aneurysm (AAA), according to an observational study in Arteriosclerosis, Thrombosis … (Source: Physician's First Watch current issue)

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Effect of Coronary Atherosclerosis and Myocardial Ischemia on Plasma Levels of High-Sensitivity Troponin T and NT-proBNP in Patients With Stable Angina.

Thu, 11 Feb 2016 00:00:00 +0100

CONCLUSIONS: In patients with stable angina, the presence and extent of coronary atherosclerosis is related with circulating levels of hs-cTnT, also in the absence of ischemia, suggesting an ischemia-independent mechanism of hs-cTnT release. Obstructive CAD causing myocardial ischemia is associated with increased levels of NT-proBNP. PMID: 26868212 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Profound Actions of an Agonist of Growth Hormone-Releasing Hormone on Angiogenic Therapy by Mesenchymal Stem Cells.

Thu, 11 Feb 2016 00:00:00 +0100

CONCLUSIONS: Our studies demonstrate a novel role for JI-34 to markedly improve therapeutic angiogenesis in hindlimb ischemia by increasing the viability and mobility of MSCs. These findings support additional studies to explore the full potential of growth hormone-releasing hormone agonists to augment cell therapy in the management of ischemia. PMID: 26868211 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture.

Thu, 11 Feb 2016 00:00:00 +0100

CONCLUSIONS: Recent active asthma increased risk of AAA and ruptured AAA. These findings document and furnish novel links between airway disease and AAA, 2 common diseases that share inflammatory aspects. PMID: 26868210 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Glycosphingolipids on Human Myeloid Cells Stabilize E-Selectin-Dependent Rolling in the Multistep Leukocyte Adhesion Cascade.

Thu, 11 Feb 2016 00:00:00 +0100

CONCLUSIONS: Glycosphingolipids likely contribute to human myeloid cell adhesion to E-selectin under fluid shear, particularly the transition of rolling cells to firm arrest. PMID: 26868209 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.

Thu, 11 Feb 2016 00:00:00 +0100

CONCLUSIONS: Nab-producing B-1b B cells are increased in Id3(Bcell KO) mice and attenuate adipose tissue inflammation and glucose intolerance in diet-induced obese mice. Additional findings are the first to identify VAT as a reservoir for human B-1 cells and to link anti-inflammatory IgM antibodies with reduced inflammation and improved metabolic phenotype in obese humans. PMID: 26868208 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Association of coronary artery calcification with liver fibrosis in Japanese patients with NAFLD

Mon, 08 Feb 2016 00:00:00 +0100

ConclusionsThe progression of arteriosclerosis and that of liver fibrosis may be associated in NAFLD patients. The FIB4 index can be easily determined and thus can be a useful marker for predicting cardiovascular events in NAFLD patients. (Source: Hepatology Research)



Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults

Sun, 07 Feb 2016 00:00:00 +0100

Conclusions Among apparently healthy adults, the microstructural findings of nephron hypertrophy and nephrosclerosis differ in their associations with kidney function, macrostructure, and risk factors. (Source: American Journal of Kidney Diseases)



Macrophage IκB Kinase α Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early Atherosclerosis.

Thu, 04 Feb 2016 00:00:00 +0100

CONCLUSIONS: Hematopoietic IKKα deficiency in mouse suppresses Akt signaling, compromising monocyte/macrophage survival and this decreases early atherosclerosis. PMID: 26848161 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Hypoxia-Inducible Factor-Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis.

Thu, 04 Feb 2016 00:00:00 +0100

CONCLUSIONS: HIF-P4H-2 inhibition may be a novel strategy for protecting against the development of atherosclerosis. The mechanisms involve beneficial modulation of the serum lipid profile and innate immune system and reduced inflammation. PMID: 26848160 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Cholesteryl Ester Transfer Protein Inhibition Is Not Yet Dead-Pro.

Thu, 04 Feb 2016 00:00:00 +0100

Authors: Barter PJ, Rye KA Abstract Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from nonatherogenic high-density lipoproteins to potentially proatherogenic non-high-density lipoprotein fractions. Human genetic studies and human cohort studies have concluded that CETP gene polymorphisms associated with decreased CETP activity are accompanied by a significantly lower risk of atherosclerotic cardiovascular disease. Inhibition of CETP in rabbits reduces development of diet-induced atherosclerosis. Inhibition of CETP in humans reduces non-high-density lipoprotein cholesterol while increasing high-density lipoproteins cholesterol, consistent with a reduced risk of having an atherosclerotic cardiovascular disease event. The failure of randomized human clinical o...

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Lipoprotein-Associated Phospholipase A2 and Incident Peripheral Arterial Disease in Older Adults: The Cardiovascular Health Study.

Thu, 04 Feb 2016 00:00:00 +0100

CONCLUSIONS: Higher Lp-PLA2 mass and activity were associated with development of both incident clinical PAD and low ABI. Future studies are needed to determine whether pharmacological inhibition of Lp-PLA2 reduces the incidence of PAD. PMID: 26848158 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow.

Thu, 04 Feb 2016 00:00:00 +0100

CONCLUSIONS: Taken together, our data indicate that (1) thrombin increases the platelet thrombus volume; (2) tissue factor drives the formation of fibrin outside of the platelet thrombus; (3) limitation of platelet adhesion redirects fibrin from bottom to top of the thrombus; (4) a lower shear rate promotes thrombus coverage with fibrin; (5) the fibrin distribution pattern determines thrombus microelasticity; and (6) the thrombus-forming process is reduced in patients with diverse hemostatic defects. PMID: 26848157 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Probucol-Oxidized Products, Spiroquinone and Diphenoquinone, Promote Reverse Cholesterol Transport in Mice.

Thu, 04 Feb 2016 00:00:00 +0100

CONCLUSIONS: Spiroquinone and diphenoquinone increase functional ATP-binding cassette transporter A1 in both the macrophages and the liver, elevate plasma HDL-cholesterol, and promote overall reverse cholesterol transport in vivo. These compounds are promising as therapeutic reagents against atherosclerosis. PMID: 26848156 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Blood Pressure Is a Major Modifiable Risk Factor Implicated in Pathogenesis of Intraplaque Hemorrhage: An In Vivo Magnetic Resonance Imaging Study.

Thu, 04 Feb 2016 00:00:00 +0100

CONCLUSIONS: Low diastolic BP was independently associated with IPH, which was unlikely because of treatment difference or BP changes from systemic atherosclerosis. Hemodynamic changes from lowering diastolic BP may be the pathophysiological link. Prospective serial studies are needed to assess whether BP and antiplatelet use are associated with the development of new or repeated IPH. PMID: 26848155 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.

Mon, 01 Feb 2016 00:00:00 +0100

CONCLUSIONS: NSun2 upregulates the expression of ICAM-1 by methylating ICAM-1 mRNA. This regulatory process impacts on vascular inflammation and allograft arteriosclerosis. PMID: 26838785 [PubMed - as supplied by publisher] (Source: Circulation Research)

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Correction.

Sat, 30 Jan 2016 09:41:02 +0100

Authors: PMID: 26819468 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Systems Biology and Noninvasive Imaging of Atherosclerosis.

Sat, 30 Jan 2016 09:41:02 +0100

Authors: Calcagno C, Mulder WJ, Nahrendorf M, Fayad ZA PMID: 26819466 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Role for Hyaluronan Synthase 3 in the Response to Vascular Injury.

Sat, 30 Jan 2016 09:41:02 +0100

Authors: Puré E, Krolikoski M, Monslow J PMID: 26819465 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



A Nuclear Attack on Thrombosis and Inflammation.

Sat, 30 Jan 2016 09:41:02 +0100

Authors: Conway EM PMID: 26819464 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease.

Sat, 30 Jan 2016 09:41:02 +0100

Authors: Reiner AP, Susztak K PMID: 26819463 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



The Plot Thickens Further for Type I Interferons in Atherosclerotic Disease.

Sat, 30 Jan 2016 09:41:02 +0100

Authors: de Winther MP PMID: 26819462 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



LRP in Endothelial Cells: A Little Goes a Long Way.

Sat, 30 Jan 2016 09:41:02 +0100

Authors: Strickland DK, Muratoglu SC PMID: 26819461 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Emerging Roles of PCSK9: More Than a One-Trick Pony.

Sat, 30 Jan 2016 09:41:02 +0100

Authors: Moore KJ, Goldberg IJ PMID: 26819460 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Eating frequency predicts new onset hypertension and the rate of progression of blood pressure, arterial stiffness, and wave reflections

Sat, 30 Jan 2016 04:04:56 +0100

Background: Cross-sectional evidence indicates that eating frequency correlates with blood pressure, hypertension, and related target organ damage. The aim of the present study was to prospectively assess eating frequency as a predictor of arteriosclerosis progression and new onset hypertension over a follow-up period of 5 years in adults without cardiovascular disease. Methods: Eating frequency among other dietary parameters was evaluated in 115 nondiabetic study participants from a general population sample (54 ± 9.1 years, 45 women) at a baseline visit. Metabolic parameters known to be associated with eating frequency, markers of arteriosclerosis, including augmentation index, pulse wave velocity, SBP, and DBP were evaluated in all volunteers at baseline and after a 5-year follow-...

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RhoA/Rho-Kinase in the Cardiovascular System.

Fri, 22 Jan 2016 00:00:00 +0100

Authors: Shimokawa H, Sunamura S, Satoh K Abstract Twenty years ago, Rho-kinase was identified as an important downstream effector of the small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important roles of Rho-kinase in the cardiovascular system. The RhoA/Rho-kinase pathway is now widely known to play important roles in many cellular functions, including contraction, motility, proliferation, and apoptosis, and its excessive activity induces oxidative stress and promotes the development of cardiovascular diseases. Furthermore, the important role of Rho-kinase has been demonstrated in the pathogenesis of vasospasm, arteriosclerosis, ischemia/reperfusion injury, hypertension, pulmonary hypertension, and heart failure. Cyclophilin A is secreted by vascu...



Discoidin Domain Receptor-1 Regulates Calcific Extracellular Vesicle Release in Vascular Smooth Muscle Cell Fibrocalcific Response via Transforming Growth Factor-β Signaling.

Thu, 21 Jan 2016 00:00:00 +0100

CONCLUSIONS: DDR-1 interacts with the TGF-β pathway to restrict calcifying EV-mediated mineralization and fibrosis by vSMCs. We therefore establish a novel mechanism of cell-matrix homeostasis in atherosclerotic plaque formation. PMID: 26800565 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization.

Thu, 21 Jan 2016 00:00:00 +0100

CONCLUSIONS: ApoER2 contributes cooperatively with endothelial cell protein C receptor and protease activated receptor 1 to APC-initiated endothelial antiapoptotic and barrier protective signaling. PMID: 26800564 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Factor XI Deficiency Protects Against Atherogenesis in Apolipoprotein E/Factor XI Double Knockout Mice.

Thu, 21 Jan 2016 00:00:00 +0100

CONCLUSIONS: FXI deprivation was shown to slow down atherogenesis in mice. The results suggest that the development of atherosclerosis can be prevented by targeting FXI. PMID: 26800563 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Smooth Muscle Hypoxia-Inducible Factor 1α Links Intravascular Pressure and Atherosclerosis.

Thu, 21 Jan 2016 00:00:00 +0100

CONCLUSIONS: HIF1α in vascular smooth muscle plays an important role in the pathogenesis of atherosclerosis, and may provide a mechanistic link between blood pressure, vascular inflammation, and lipid deposition. PMID: 26800562 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Endothelial Dysfunction in Human Diabetes Is Mediated by Wnt5a-JNK Signaling.

Thu, 21 Jan 2016 00:00:00 +0100

CONCLUSIONS: Our findings demonstrate that noncanonical Wnt5a signaling and JNK activity contribute to vascular insulin resistance and endothelial dysfunction and may represent a novel therapeutic opportunity to protect the vasculature in patients with diabetes mellitus. PMID: 26800561 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Cerebral Small Vessel Disease and Arterial Stiffness: Tsunami Effect in the Brain

Wed, 20 Jan 2016 22:10:23 +0100

Background: Cerebral small vessel diseases, including silent lacunar infarcts, white matter hyperintensities, and microbleeds, pose a risk for cerebrovascular disease, cognitive impairment, and the geriatric syndrome via effects on arterial stiffness. However, the vascular, physiological, and metabolic roles of arterial stiffness in cerebral small vessel diseases remain unclear. Summary: Arterial stiffness can be assessed using various indicators such as the ankle-brachial index, pulse wave velocity, cardio-ankle vascular index, and augmentation index. Arterial stiffness is independently associated with all components of cerebral small vessel disease including silent lacunar infarcts, white matter hyperintensities, and microbleeds, although there are some methodological differences between...



Cerebral Small Vessel Disease and Arterial Stiffness: Tsunami Effect in the Brain?

Tue, 19 Jan 2016 15:21:45 +0100

Background: Cerebral small vessel diseases, including silent lacunar infarcts, white matter hyperintensities, and microbleeds, pose a risk for cerebrovascular disease, cognitive impairment, and the geriatric syndrome via effects on arterial stiffness. However, the vascular, physiological, and metabolic roles of arterial stiffness in cerebral small vessel diseases remain unclear. Summary: Arterial stiffness can be assessed using various indicators such as the ankle-brachial index, pulse wave velocity, cardio-ankle vascular index, and augmentation index. Arterial stiffness is independently associated with all components of cerebral small vessel disease including silent lacunar infarcts, white matter hyperintensities, and microbleeds, although there are some methodological differences between...



Homocysteine Metabolism, Atherosclerosis, and Diseases of Aging.

Sat, 16 Jan 2016 19:06:02 +0100

Authors: McCully KS Abstract The importance of homocysteine in vascular function and arteriosclerosis was discovered by demonstration of arteriosclerotic plaques in children with homocystinuria caused by inherited enzymatic deficiencies of cystathionine synthase, methionine synthase, or methylene-tetrahydrofolate reductase. According to the homocysteine theory of arteriosclerosis, an elevated blood homocysteine level is an important risk factor for atherosclerosis in subjects without these rare enzymatic abnormalities. The homocysteine theory is supported by demonstration of arterial plaques in experimental animals with hyperhomocysteinemia, by discovery of a pathway for conversion of homocysteine thiolactone to sulfate in cell cultures from children with homocystinuria, and by dem...

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Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function

Fri, 15 Jan 2016 00:00:00 +0100

In heart failure with preserved ejection fraction (HFpEF), the complex pathogenesis hinders development of effective therapies. Since HFpEF and arteriosclerosis share common risk factors, it is conceivable that stiffened arterial wall in HFpEF impairs baroreflex function. Previous investigations have indicated that the baroreflex regulates intravascular stressed volume and arterial resistance in addition to cardiac contractility and heart rate. We hypothesized that baroreflex dysfunction impairs regulation of left atrial pressure (LAP) and increases the risk of pulmonary edema in freely moving rats. In 15-wk Sprague-Dawley male rats, we conducted sinoaortic denervation (SAD, n = 6) or sham surgery (Sham, n = 9), and telemetrically monitored ambulatory arterial pressure (AP) and LAP. We com...



Sleep Fragmentation Linked to Cerebrovascular Pathology Sleep Fragmentation Linked to Cerebrovascular Pathology

Thu, 14 Jan 2016 22:19:06 +0100

Greater sleep fragmentation -- defined as interruption of sustained sleep by repeated awakenings -- is associated with arteriosclerosis and subcortical infarcts at autopsy. Medscape Medical News (Source: Medscape Medical News Headlines)



Hemodialysis patients with intradialytic rise in blood pressure display higher baseline aortic stiffness and negligible drop in augmentation index with dialysis

Thu, 14 Jan 2016 00:00:00 +0100

Conclusions This study shows that aortic stiffness and wave reflections are higher and not affected by dialysis procedure in patients with intradialytic SBP rise, suggesting that accelerated arteriosclerosis may be one possible explanation for the heightened cardiovascular risk associated with intradialytic hypertension. (Source: International Urology and Nephrology)



Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice.

Thu, 14 Jan 2016 00:00:00 +0100

CONCLUSIONS: Hypercholesterolemic/hypertensive mice are the first model of fibrotic AVS. Hypercholesterolemic/hypertensive mice develop severe AVS in the absence of significant calcification, a feature that resembles AVS in children and some adults. Structural changes at the base of the valve leaflets include lengthening of the raphe, remodeling of collagen, and asymmetry of the leaflets. Genes were identified that may contribute to the development of fibrotic AVS. PMID: 26769049 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow.

Thu, 14 Jan 2016 00:00:00 +0100

CONCLUSIONS: This study demonstrates that the FXI-thrombin axis contributes to distal platelet activation and procoagulant microaggregate formation in the blood flow downstream of the site of thrombus formation. Our data highlight FXI as a novel therapeutic target for inhibiting distal thrombus formation without affecting proximal platelet adhesion. PMID: 26769048 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Inhibition of Thrombin With PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental Atherosclerosis.

Thu, 14 Jan 2016 00:00:00 +0100

CONCLUSIONS: These observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin nanoparticle therapeutics as a rapid-acting anti-inflammatory strategy in atherosclerosis to reduce thrombotic risk. PMID: 26769047 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Bone Morphogenic Protein 4-Smad-Induced Upregulation of Platelet-Derived Growth Factor AA Impairs Endothelial Function.

Thu, 14 Jan 2016 00:00:00 +0100

CONCLUSIONS: The present study provides novel evidences showing PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1/5- and SMAD4-dependent mechanisms. Inhibition of PGDF-AA ameliorates vascular dysfunction in diabetic mice. PMID: 26769046 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Induction of Angiogenesis by a Type III Phosphodiesterase Inhibitor, Cilostazol, Through Activation of Peroxisome Proliferator-Activated Receptor-γ and cAMP Pathways in Vascular Cells.

Thu, 14 Jan 2016 00:00:00 +0100

CONCLUSIONS: Our data suggest that the favorable effects of cilostazol on ischemic leg might be through the angiogenesis through the induction of HGF via peroxisome proliferator-activated receptor-γ and cAMP pathways. PMID: 26769045 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Subclinical arteriosclerosis and osteoprotegerin levels in a population with systemic lupus erythematous in the south of Europe.

Wed, 13 Jan 2016 00:00:00 +0100

Authors: López-Robles C, Rios-Fernández R, Callejas-Rubio JL, Moreno-Escobar E, Martín-DeLaFuente P, Ortego-Centeno N PMID: 26768749 [PubMed - as supplied by publisher] (Source: Lupus)



MicroRNA-150 Suppression of Angiopoetin-2 Generation and Signaling Is Crucial for Resolving Vascular Injury.

Thu, 07 Jan 2016 00:00:00 +0100

CONCLUSIONS: miR-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis. PMID: 26743170 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.

Thu, 07 Jan 2016 00:00:00 +0100

CONCLUSIONS: Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy. PMID: 26743169 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis.

Thu, 07 Jan 2016 00:00:00 +0100

CONCLUSIONS: Mutations in the activation peptide of full-length recombinant FXIII regulate activation rates by thrombin, and V34L influences in vivo thrombus formation by increased cross-linking of the clot. PMID: 26743168 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Consumer Health Tips: How to Avoid Medication Errors

Thu, 07 Jan 2016 00:00:00 +0100

Medication errors: Cut your risk with these tips Grapefruit: Beware of dangerous medication interactions Too much vitamin C: Is it harmful? Chronic stress: Can it cause depression? Arteriosclerosis/atherosclerosis overview   (Source: News from Mayo Clinic)



Endothelin-1 Expression Associated with Lipid Peroxidation and Nuclear Factor-κB Activation in Type 2 Diabetes Mellitus Patients with Angiopathy and Limb Amputation

Fri, 01 Jan 2016 06:00:00 +0100

Conclusions: These results suggest that elevation of endothelin-1 and lipid peroxide levels is involved in the pathogenesis of diabetic foot amputation. An increase of lipid peroxide and endothelin-1 associated with nuclear factor-κB activation plays an important role in the development of diabetic angiopathies. (Source: Plastic and Reconstructive Surgery)



Coronary Artery Disease in the Human Immunodeficiency Virus Seropositive Population

Fri, 01 Jan 2016 06:00:00 +0100

The development of efficient combined antiretroviral therapies has lengthened the mean life span of the population affected with human immunodeficiency virus (HIV) transforming this terminal infection to a chronic yet manageable disease. Nonetheless, patients with HIV—treatment naive or not—exhibit larger risks for coronary artery disease than the noninfected population. Moreover, coronary atherosclerosis/arteriosclerosis may be the most prevalent condition in the HIV-infected population that is being accentuated by the effects of viral agents and the antiretroviral drugs, especially protease inhibitors. Nonetheless, generalized metabolic dysfunctions and premature senescence are often attributed to the viremia caused by the HIV infection directly and primarily. Therefore, a multifacto...

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Vegetable oil‐mediated thermal isomerization of (all‐E)‐lycopene: facile and efficient production of Z‐isomers

Fri, 01 Jan 2016 00:00:00 +0100

This study has developed an efficient production method for Z‐isomers of lycopene by heating (all‐E)‐lycopene in edible vegetable oils, in which neither organic solvents nor food additives are used. It would be practically feasible to utilize this procedure for the food, drink, and dietary supplement manufacturing, as well as for daily cooking at home. (Source: European Journal of Lipid Science and Technology)



Quantitative and semi‐quantitative histopathological examination of renal biopsies in healthy individuals, and associations with kidney function

Fri, 01 Jan 2016 00:00:00 +0100

This study assesed the prevalence of histopathological changes in renal biopsies from healthy individuals, and the association with age, sex and smoking. Donor biopsies from 109 subjects were obtained from living kidney donors, and blood and urine samples were collected together with medical history. All biopsies were scored according to the Banff ‘97 classification with some modifications. The parameters included in this study were tubular atrophy, interstitial fibrosis, glomerulosclerosis, arteriosclerosis, arteriolohyalinosis and a sclerosis score. An alternative scoring system for tubular atrophy was examined (using ≤5% rather than <1% as a cut‐off for grade 0). Glomerular filtration rate was measured in most cases as chromium ethylenediaminetetra‐acetic acid (Cr‐EDTA) cle...



Arteriosclerosis, Thrombosis, and Vascular Biology.

Sun, 27 Dec 2015 08:22:10 +0100

Authors: PMID: 26700132 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Human Macrophage Genetic Engineering.

Sun, 27 Dec 2015 08:22:09 +0100

Authors: Smith JD PMID: 26700133 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Primed to Understand Fibrinogen in Cardiovascular Disease.

Sun, 27 Dec 2015 08:22:04 +0100

Authors: Wolberg AS PMID: 26700134 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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Catch and Release: NG2-Coated Vascular Smooth Muscle Cells Capture Lipoproteins for Macrophages.

Sun, 27 Dec 2015 08:22:03 +0100

Authors: Fogelstrand P, Borén J PMID: 26700135 [PubMed - in process] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)



Laser versus balloon angioplasty in endovascular management of infragenicular tibial arterial occlusion in critical limb ischemic TASC D: Six L Trial

Wed, 23 Dec 2015 00:00:00 +0100

Publication date: Available online 23 December 2015 Source:Journal of Indian College of Cardiology Author(s): Sherif Sultan, Wael Tawfick, Edel Kavanagh, Mohamed Sultan, Niamh Hynes We aim to compare cool excimer laser-assisted angioplasty versus tibial balloon angioplasty (TBA) in critical limb ischemia (CLI) patients, with tibial artery occlusive disease. From June 2005 to October 2010, 1506 patients were referred with peripheral vascular disease. 80 patients underwent 89 endorevascularizations for tibial occlusions; 47 using TBA and 42 using cool excimer laser-assisted angioplasty. All patients were Rutherford Category 4, 5, or 6, with TASC D lesions. Five-year sustained clinical improvement was enhanced with laser angioplasty (76%) compared to TBA (62%; P =0.1004). Rate of revas...



The pathogenesis of arteriosclerosis

Wed, 23 Dec 2015 00:00:00 +0100

(Source: International Journal of Epidemiology)



Postepy Hig Med Dosw 2015; 69:838-852 "Supplementation with omega fatty acids in various diseases"

Tue, 22 Dec 2015 00:23:54 +0100

For some decades, an increase in propagation of coronary heart disease, obesity, diabetes, tumors and mental disorders has been observed. Consequently, new and effective methods of treatment of these diseases using drugs and diet supplements have been developed. A promising solution is the use of polyunsaturated fatty acids in the treatment of some diseases. These compounds have broad application in prevention of many diseases and are used to support standard therapies. Their activity is connected with participation in metabolic processes regulating biochemical transformations in cells and tissues. Omega-3 fatty acids regulate production of cytokines, increased levels of which may contribute to occurrence of chronic inflammatory diseases, autoaggression of the immunological system, arter...



Identification of an Amino Acid Residue Critical for Plasma Membrane Localization of ATP-Binding Cassette Transporter G1.

Tue, 22 Dec 2015 00:00:00 +0100

CONCLUSIONS: Leu at position 550/562 in mABCG1/hABCG1 is critical for their plasma membrane localization but not for ABCG1-mediated cholesterol efflux. Our findings indicate that the substitution of Leu to Pro at position 550 in mABCG1 may contribute to the non-cell surface localization of mABCG1 observed in the previous study. PMID: 26695502 [PubMed - as supplied by publisher] (Source: Arteriosclerosis, Thrombosis and Vascular Biology)

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