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Preview: MedWorm: Squamous Cell Carcinoma

MedWorm: Squamous Cell Carcinoma



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Squamous Cell Carcinoma category.



Last Build Date: Tue, 29 Mar 2016 14:30:26 +0100

 



Oral candidal carriage and their antifungal susceptibility pattern in potentially malignant disorders

Tue, 29 Mar 2016 09:23:37 +0100

Background: Significant numbers of oral squamous cell carcinoma develop from potentially malignant disorders (PMDs). Candida has been extensively studied in leukoplakia, erythroplakia, Oral submucous fibrosis and Lichen planus. Candida infection has been linked with malignant transformation ever since it was reported to cause candidal oral leukoplakia. The improvement of epithelial dysplasia following elimination of Candida spp. from infected tissue is added evidence. Eradication of Candida spp. (Source: International Journal of Infectious Diseases)

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Cervical cytology as a diagnostic tool for genital schistosomiasis and cervical squamous cell atypia among young women from schistosoma and HIV endemic populations in South Africa

Tue, 29 Mar 2016 09:23:36 +0100

Background: Globally, Africa has the highest prevalence of HIV, schistosomiasis and another neglected entity: cervical cancer. Genital schistosomiasis manifests in lesions that are hypothesized to link with HIV and cervical atypia. (Source: International Journal of Infectious Diseases)



Pd33-04 pathological characteristics and prognostic indicators of different histopathological types following radical cystectomy: a large cohort with long-term follow-up

Mon, 28 Mar 2016 19:24:08 +0100

Pathological features and prognostics are better characterized for urothelial cancer (UC) compared to other histological types. Herein we determined differences in pathological features and prognostics among 4 different histological types: UC, UC with metaplasia (UCM), squamous cell carcinoma (SCC) and adenocarcinoma (ADC) utilizing a large cohort of radical cystectomy (RC) patients with long term follow up. (Source: The Journal of Urology)



Mp36-19 malignancy in biopsy proven penile lichen sclerosus

Mon, 28 Mar 2016 19:24:05 +0100

We report our experience with clinical follow up of men with biopsy proven penile LS at a large academic practice to evaluate the risk of developing cancer at a later time. (Source: The Journal of Urology)



Mp36-18 high-risk hpv subtypes in squamous cell carcinoma of the scrotum

Mon, 28 Mar 2016 19:24:05 +0100

Commercially available vaccines against high-risk human papilloma virus (HR-HPV) have been promoted for cervical cancer prevention and more recently marketed towards men for secondary preventative purposes. Previously published data have also focused on the utility of circumcision in the prevention of HPV transmission. Squamous cell carcinoma (SCC) of the scrotum is associated with infection by HR-HPV in a subset of patients. The subtypes of HR-HPV involved in this neoplasm are unknown. (Source: The Journal of Urology)



V1-04 robotic assisted inguinal lymphadenectomy for penile cancer: the md anderson cancer center technique

Mon, 28 Mar 2016 19:24:03 +0100

We present our experience with this procedure at a center with a high volume of PSCC. (Source: The Journal of Urology)

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Mp81-19 programmed death ligand-1 (pd-l1) status in north american cohort of penile squamous cell carcinoma

Mon, 28 Mar 2016 19:24:03 +0100

Objective: Penile squamous cell carcinoma (SCC) is primarily treated with surgical resection. Locally advanced and metastatic disease require a multidisciplinary approach. However, mortality and morbidity rates remain high in such patients where a molecular target of therapy is currently sought. Programmed Death Ligand-1 (PD-L1) is a co-inhibitory molecule that impairs the T-cell response by downregulating T-cell proliferation and cytokine production. Tumors cells often upregulate PD-L1 and thereby evade the host immune system. (Source: The Journal of Urology)



Mp81-13 role of 18f-fdg pet/ct in identifying inguinal nodal metastasis in patients on surveillance after primary treatment of penile squamous cell carcinoma- single centre prospective study

Mon, 28 Mar 2016 19:24:03 +0100

The extent of lymph node involvement is the most relevant prognostic factor in patients with penile cancer. Management of clinically normal groin nodes (N0 groin) in patients with carcinoma of penis is controversial. Aim of our prospective study was to assess the role of 2-18 fluro-2-deoxy-D-glucose positron emission tomography– computerized tomography (PET-CT) in detecting lymph node metastasis in carcinoma penis with clinically N0 groin during follow up. (Source: The Journal of Urology)



Mp05-03 role of penile doppler us in the preoperative assessment of penile squamous cell carcinoma patients: results from a large prospective multicenter european study

Mon, 28 Mar 2016 19:24:03 +0100

To determine the role of Penile Doppler Ultrasound (PDU) compared to Magnetic Resonance Imaging in preoperative diagnostic evaluation of patients with Penile Squamous Cell Carcinoma (Source: The Journal of Urology)



Pd10-11 comparison of survival outcomes for african-american and caucasian men with advanced penile cancer in florida

Mon, 28 Mar 2016 19:24:00 +0100

Studies suggest that there may be disparity in clinical outcomes for African American men (AAM) compared to Caucasian men (CM) with penile squamous cell carcinoma (SCC). We sought to determine whether there was a survival difference for African American versus Caucasian men, particularly in locally advanced and metastatic cases of penile SCC where disease mortality is highest. (Source: The Journal of Urology)



ANO1 protein as a potential biomarker for esophageal cancer prognosis and precancerous lesion development prediction.

Mon, 28 Mar 2016 17:23:02 +0100

CONCLUSIONS: Positive ANO1 is a promising biomarker to predict the unfavorable outcome for ESCC patients. More importantly, it can predict disease progression of precancerous lesions. PMID: 27016410 [PubMed - as supplied by publisher] (Source: Oncotarget)

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Nimotuzumab plus paclitaxel and cisplatin as the first line treatment for advanced esophageal squamous cell cancer: A single centre prospective phase II trial

Sun, 27 Mar 2016 22:00:00 +0100

Nimotuzumab (N) is a humanized anti‐epidermal growth factor receptor monoclonal antibody. This prospective, single‐armed, open label phase II study was conducted to evaluate the efficacy and safety of the combination of paclitaxel (T)/cisplatin (P) with nimotuzumab (N) as first‐line treatment in advanced esophageal squamous cell carcinoma (ESCC). Patients with pathologic confirmed unresectable locally advanced or metastatic ESCC were treated with the TPN regimen: nimotuzumab 200 mg weekly, paclitaxel 175 mg/m2 on day 1 and cisplatin 30 mg/m2 on days 1 and 2; repeat cycle every 3 weeks for six cycles. Radiotherapy was allowed to be admitted after four cycles of TPN treatment. The primary endpoint was the objective response rate (ORR). The secondary endpoint was the overall survival (O...



Retrograde intra‐arterial chemotherapy and daily concurrent proton beam therapy for recurrent oral cavity squamous cell carcinoma: Analysis of therapeutic results in 46 cases

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionThese findings suggest that proton beam therapy combined with intra‐arterial infusion chemotherapy could be applied effectively and safely for patients with recurrent oral cavity SCC. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



Association of genetic variants with tumor HPV16 status and survival in squamous cell carcinoma of the oropharynx

Sun, 27 Mar 2016 22:00:00 +0100

Squamous cell carcinoma of the oropharynx (SCCOP) is a subtype of squamous cell carcinoma of the head and neck (SCCHN) [1]. In the U.S., approximately 13,510 new cases of SCCOP are diagnosed, and 2330 deaths result from these cancers, annually [2]. Although tobacco smoking and alcohol consumption remain significant risk factors for SCCOP, human papillomavirus (HPV) accounts for a growing proportion of cases, particularly in young adults [1,3]. There are more than 100 different HPV types; about 20 of these have oncogenic potential (i.e., the high-risk types) [4]. (Source: Oral Oncology)



Need for Sun cream with your manicure? - Dangers of UV nail dryers

Sun, 27 Mar 2016 22:00:00 +0100

Over 102,000 cases of non-melanoma skin cancer (NMSC) were reported in 2011 with rates growing annually.1 The main NMSC is basal cell carcinoma accounting for 75%, with others including squamous cell carcinoma. It has been estimated that 90% of NMSC originates from exposure to UV light; which initiates malignant transformation in keratinocytes and reduces the protective inflammatory and immune.2 The increasing incidence has been attributed to an ageing population, rises in recreational activity associated with skin exposure, and use of sunbeds. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)



Macroscopic technique for the evaluation of oral tongue tumour thickness: a reliable intraoperative method

Sun, 27 Mar 2016 22:00:00 +0100

There is no reliable method to assess tumour thickness preoperatively or intraoperatively in cases of oral tongue squamous cell carcinoma (SCC). The purpose of this study was to evaluate the efficacy of a macroscopic technique to measure tumour thickness. This was a prospective study of 51 consecutive patients with T1/T2 primary SCC of the oral tongue. All patients underwent primary resection with ipsilateral neck dissection. Thickness measurements were obtained using Vernier calipers on the fresh specimen. (Source: International Journal of Oral and Maxillofacial Surgery)

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Correlation of Lymph Node Density with Negative Outcome Predictors in Oral and Maxillofacial Squamous Cell Carcinoma

Sun, 27 Mar 2016 22:00:00 +0100

Lymph node density is defined as the number of positive lymph nodes per total number of excised lymph nodes. In oral and maxillofacial cancer, there are recent data showing that increased lymph node density leads to worse outcomes for patients. However, we are lacking data correlating lymph node density with other known risk parameters. Our study aims to identify if a direct correlation exists between cervical lymph node density, depth of invasion, perineural invasion, and extracapsular tumor spread. (Source: Journal of Oral and Maxillofacial Surgery)



Effect of sorafenib on cisplatin-based chemoradiation in head and neck cancer cells.

Sun, 27 Mar 2016 05:28:02 +0100

In this study we investigated its effect on combined CRT treatment using cisplatin.Radio- and chemosensitivity with and without sorafenib was measured in four HNSCC cell lines and normal fibroblasts (NF) by colony formation assay. Apoptosis and cell cycle analysis were performed by flow cytometry.In HNSCC cells, sorafenib enhanced the antiproliferative effect of cisplatin without affecting apoptosis induction and with only minor effects on cell inactivation. Sorafenib added prior to irradiation enhanced cellular radiosensitivity in three of the tested HNSCC cell lines and caused massive overall cell inactivation when combined with CRT. In contrast, sorafenib did not radiosensitize NF and reduced cisplatin-induced cell inactivation. Cell inactivation by IR and cisplatin is further increased...



Long noncoding RNA MALAT1 promotes malignant development of esophageal squamous cell carcinoma by targeting β-catenin via Ezh2.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Wang W, Zhu Y, Li S, Chen X, Jiang G, Shen Z, Qiao Y, Wang L, Zheng P, Zhang Y Abstract Evidences have shown that lncRNAs involve in the initiation and progression of various cancers including esophageal squamous cell carcinoma (ESCC). The aberrant expression of lncRNA MALAT1 was investigated in 106 paired ESCC tissues and adjacent non-cancerous tissues by qRT-PCR. Down-regulated MALAT1 and Ezh2 over-expression plasmid were constructed respectively to analyze the expression of β-catenin, Lin28 and Ezh2 genes. We found that the MALAT1 expression level was higher in human ESCC tissues (P=0.0011), which was closely correlated with WHO grade (P=0.0395, P=0.0331), lymph node metastasis (P=0.0213) and prognosis (P=0.0294). Silencing of MALAT1 expression inhibited cell prolifera...



mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Coppock JD, Vermeer PD, Vermeer DW, Lee KM, Miskimins WK, Spanos WC, Lee JH Abstract Effective treatments for recurrent/metastatic human papillomavirus-positive (HPV+) head and neck squamous cell cancer (HNSCC) are limited. To aid treatment development, we characterized a novel murine model of recurrent/metastatic HPV+ HNSCC. Further analysis of the parental tumor cell line and its four recurrent/metastatic derivatives led to preclinical testing of an effective treatment option for this otherwise fatal disease. Reverse phase protein arrays identified key signaling cascades in the parental and recurrent/metastatic cell lines. While protein expression profiles differed among the recurrent/metastatic cell lines, activated proteins associated with the mTOR signaling cascade we...



Predictive value of EGFR overexpression and gene amplification on icotinib efficacy in patients with advanced esophageal squamous cell carcinoma.

Sun, 27 Mar 2016 05:28:02 +0100

In conclusion, our study suggests that EGFR overexpression might potentially be used in predicting the efficacy in patients treated with Icotinib. These data have implications for both clinical trial design and therapeutic strategies. PMID: 27013591 [PubMed - as supplied by publisher] (Source: Oncotarget)

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Prevalence characteristics of high-risk human papillomaviruses in women living in Shanghai with cervical precancerous lesions and cancer.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Gu Y, Ma C, Zou J, Zhu Y, Yang R, Xu Y, Zhang Y Abstract A complete understanding of the natural history of infection with high-risk human papillomaviruses (HPVs) in cervical cancer requires data from regional and ethnic studies. The prevalence of high-risk HPVs was evaluated retrospectively in 2040 patients with cervicitis, 239 with cervical intraepithelial neoplasia grade 1 (CIN1), 242 with CIN2/3, and 42 patients with invasive squamous cell carcinoma (SCC) based on data from patients who visited our hospital between May 2013 and May 2015. The rates of high-risk HPV infection in patients with cervicitis, CIN1, CIN2/3, and invasive SCC were 40.8%, 74.9%, 70.2%, and 83.3%, respectively. The three most dominant HPV genotypes were HPV16, 58, and 52. HPV16 and HPV58 positivit...



Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD Abstract Human papillomavirus induced (HPV+) cancer incidence is rapidly rising, comprising 60-80% of oropharyngeal squamous cell carcinomas (OPSCCs); while rare, recurrent/metastatic disease accounts for nearly all related deaths. An in vivo pre-clinical model for these invasive cancers is necessary for testing new therapies. We characterize an immune competent recurrent/metastatic HPV+ murine model of OPSSC which consists of four lung metastatic (MLM) cell lines isolated from an animal with HPV+ OPSCC that failed cisplatin/radiation treatment. These individual metastatic clonal cell lines were tested to verify their origin (parental transgene expression and define their physiologi...



Epigenetic mediated silencing of EYA4 contributes to tumorigenesis in oral dysplastic cells

Sat, 26 Mar 2016 23:13:49 +0100

This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)



Single-port video-assisted thoracic surgery for early lung cancer: initial experience in Japan.

Sat, 26 Mar 2016 22:10:02 +0100

CONCLUSIONS: SPVATS is a safe and feasible technique, and is promising for next-generation thoracoscopic surgery. It may also reduce postoperative wound pain and contribute to improvements in the activities of daily living of patients. PMID: 27014483 [PubMed] (Source: Journal of Thoracic Disease)



Vulvar Lichen Sclerosus and Neoplastic Transformation: A Retrospective Study of 976 Cases

Sat, 26 Mar 2016 08:13:15 +0100

Conclusions: Vulvar lichen sclerosus has a nonnegligible risk of neoplastic transformation and requires a careful and lifelong follow-up in all patients, particularly in elderly women. Early clinical and histological detection of preinvasive lesions is essential to reduce the risk of vulvar cancer. (Source: Journal of Lower Genital Tract Disease)

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Growth factor expression mediates resistance to EGFR inhibitors in head and neck squamous cell carcinomas

Fri, 25 Mar 2016 23:00:00 +0100

Head and neck squamous cell carcinoma (HNSCC) is the 6th most frequently arising tumor worldwide. According to recent estimates from the GLOBOCAN project 2012 the incidence of head and neck cancer (HNC) was >500000 cases per year worldwide. More than 350000 deaths are attributable to HNSCC annually [1]. While local and locoregionally-advanced HNSCC can be treated effectively with surgery, radiation, or chemoradiotherapy, recurrent/metastatic disease prognosis remains poor and both chemotherapy and targeted therapy with the anti-EGFR antibody cetuximab are poorly effective. (Source: Oral Oncology)



Changes in the salivary microbiota of oral leukoplakia and oral cancer

Fri, 25 Mar 2016 23:00:00 +0100

Oral cancer is one of the most prevalent cancers in the world, with oral squamous cell carcinoma (OSCC) accounting for 90% of all oral cancers [1]. The oral cavity is the second microbiome habitat in the human body and harbors numerous microbiota; an estimated 500–700 bacteria belonging to different species are present here [2]. To better understand the relationship between the salivary microbiota and oral leukoplakia (OLK) and OSCC, we evaluated changes in the salivary microbiota of patients with OSCC and OLK relative to the oral bacterial profiles in healthy controls (HCs) in present study. (Source: Oral Oncology)



Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo.

Fri, 25 Mar 2016 17:35:02 +0100

This study provides further experimental data to confirm the potential of VP22-based intercellular delivery strategies for enhancing the efficacy of gene therapy for cancer treatment. PMID: 27004535 [PubMed - as supplied by publisher] (Source: Oncology Reports)



Preoperative serum fibrinogen is an independent prognostic factor in operable esophageal cancer.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Zhang SS, Lei YY, Cai XL, Yang H, Xia X, Luo KJ, Su CH, Zou JY, Zeng B, Hu Y, Luo HH Abstract In order to fully elucidate the association between serum fibrinogen and prognosis of esophageal cancer, we examined serum fibrinogen concentrations in 1512 patients who underwent esophagectomy by the Clauss method. The impact of fibrinogen on overall survival and disease-free survival was analyzed using the Kaplan-Meier method and Cox proportional hazard models. Hyperfibrinogenemia was significantly associated with older age, male gender, smoking, alcohol consumption, weight loss, advanced pathological T stage and lymph node metastasis. Patients with hyperfibrinogenemia exhibited poor OS (HR=1.20, 95%CI: 1.04-1.38, P=0.012) and DFS (HR=1.18, 95%CI: 1.03-1.35, P=0.019). Subgroup a...



A novel prognostic score model incorporating CDGSH Iron Sulfur Domain2 (CISD2) predicts risk of disease progression in laryngeal squamous cell carcinoma.

Fri, 25 Mar 2016 17:33:04 +0100

CONCLUSIONS: CISD2 was up-regulated in LSCC. The novel C-N model, which includes CISD2 levels and N classification, is more accurate than conventional TNM classification for predicting PFS in LSCC. PMID: 27007153 [PubMed - as supplied by publisher] (Source: Oncotarget)

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MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin.

Fri, 25 Mar 2016 17:33:04 +0100

In this study, we investigated the mechanism of MAPK1E322K-mediated EGFR activation in the context of erlotinib sensitivity. We demonstrated increased AREG secretion in HNSCC cell lines harboring endogenous or exogenous MAPK1E322K compared to wild type MAPK1. We found inhibition or knockdown of MAPK1 with siRNA resulted in reduced secretion of AREG and decreased sensitivity to erlotinib in the setting of MAPK1E322K. MAPK1E322K was associated with increased AREG secretion leading to an autocrine feedback loop involving AREG, EGFR and downstream signaling. Knockdown of AREG in HNSCC cells harboring MAPK1E322K abrogated EGFR signaling and decreased sensitivity to erlotinib in vitro and in vivo. These cumulative findings implicate increased AREG secretion and EGFR activation as contributing to...



New miRNA expression abnormalities in laryngeal squamous cell carcinoma.

Fri, 25 Mar 2016 15:40:03 +0100

CONCLUSIONS: The change in miRNA expression is frequent than the expression of other tested genes. The expression of passenger strands such as miR-21-3p and miR-139-3p, which are rarely investigated, is also significantly affected in laryngeal cancer. While PIK3R1, HACE1, miR-139-3p, and miR-885-5p may act as tumor suppressor genes in the studied tumour type, miR-21-3p and miR-525-5p seem to have oncogenic properties. Our findings suggest that miR-885-5p and PIK3R1 are the best indicators for the classification of laryngeal cancer tissue and normal mucosa. PMID: 27002759 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)



The proposed physiology-based FDG PET/CT criteria in reducing false-positive results in advanced head and neck cancer after chemoradiotherapy.

Fri, 25 Mar 2016 10:50:01 +0100

CONCLUSION: By incorporating physiological changes following CCRT, our visual rating criteria improved the accuracy of the currently used FDG PET/CT visual rating system, especially the number of false-positive cases with advanced HNSCC after CCRT. PMID: 27007664 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)



Tracheo-parenchymal fistula following concurrent chemo-radiation for stage III NSCLC

Thu, 24 Mar 2016 23:00:00 +0100

We present a rare care of trachea-pulmonary fistula formation after concurrent chemo and radiation in a patient with Squamous Cell Cancer (SCC). (Source: Respiratory Medicine Case Reports)



Transcriptional Activation of ID1 by c-Jun/c-Fos [Signal Transduction]

Thu, 24 Mar 2016 23:00:00 +0100

ID1 (inhibitor of differentiation/DNA binding 1) acts an important role in metastasis, tumorigenesis, and maintenance of cell viability. It has been shown that the up-regulation of ID1 is correlated with poor prognosis and the resistance to chemotherapy of human cancers. However, the underlying molecular mechanism remains elusive. Here, we determined for the first time that up-regulating ID1 upon etoposide activation was mediated through AP-1 binding sites within the ID1 promoter and confirmed that ID1 enhanced cell resistance to DNA damage-induced apoptosis in esophageal squamous cell carcinoma cells. Ablation of c-Jun/c-Fos or ID1 expression enhanced etoposide-mediated apoptosis through increasing activity of caspase 3 and PARP cleavage. Moreover, c-Jun/c-Fos and ID1 were positively corr...

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PAR-2-mediated Nf-{kappa}B Activation Suppresses MicroRNA [Molecular Bases of Disease]

Thu, 24 Mar 2016 23:00:00 +0100

Oral cancer is the sixth most common cause of death from cancer with an estimated 400,000 deaths worldwide and a low (50%) 5-year survival rate. The most common form of oral cancer is oral squamous cell carcinoma (OSCC). OSCC is highly inflammatory and invasive, and the degree of inflammation correlates with tumor aggressiveness. The G protein-coupled receptor protease-activated receptor-2 (PAR-2) plays a key role in inflammation. PAR-2 is activated via proteolytic cleavage by trypsin-like serine proteases, including kallikrein-5 (KLK5), or by treatment with activating peptides. PAR-2 activation induces G protein-α-mediated signaling, mobilizing intracellular calcium and Nf-κB signaling, leading to the increased expression of pro-inflammatory mRNAs. Little is known, however, about PAR-2 ...



Up-regulation of HB-EGF by the COX-2/PGE2 signaling associates with the cisplatin resistance and tumor recurrence of advanced HNSCC

Thu, 24 Mar 2016 23:00:00 +0100

Head and neck squamous cell carcinoma (HNSCC) is among the most prevalent cancerous diseases around the world [1,2]. Patients with HNSCC usually present with advanced disease at their first diagnosis and treatment. Despite effective initial treatment, therapeutic failure usually develops due to local or distant relapse in these patients [3,4]. The clinical prognosis of HNSCC has remained unsatisfactory over the past decades [5,6]. The management of advanced HNSCC remains a great challenge and clinical oncologists find HNSCC difficult to cure solely by surgical resection, or irradiation alone [7–9]. (Source: Oral Oncology)



Primary surgery for advanced‐stage laryngeal cancer: A stage and subsite‐specific survival analysis

Thu, 24 Mar 2016 23:00:00 +0100

ConclusionPatients with advanced‐stage laryngeal SCC with T3 and T4a tumors, N0 neck disease, or supraglottic primaries have the greatest chance of survival when treated with primary surgery. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



Sex differences in the incidence of skin and skin‐related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide

Thu, 24 Mar 2016 15:22:23 +0100

Abstract Many skin and skin‐related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin‐related diseases affecting males vs. females, we reviewed published population‐based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers. Males had a higher incidence of ...



Morphometric differentiation of squamous cell carcinoma and adenocarcinoma of the cervix.

Thu, 24 Mar 2016 12:58:02 +0100

Authors: Wesoła M, Jeleń M Abstract The aim of the study was to define the morphometric characteristics of squamous cell carcinoma (SCC) and adenocarcinoma (AC) cells and identify opportunities to differentiate these tumors based on determination of the morphometric characteristics in order to use the results of research in the diagnosis of cervical cancer. Pap smears with two histopathologically confirmed cervix cancers were used for testing. For the morphometric assessment of cancer cells the dotSlide program was used. The mean nucleus area for AC cells was 126.62 × 10-6 m2, while this value for SCC was 145.07 × 10-6 m2 (p = 0.000132). The mean circumference of AC cells was 42.43 × 10-6 m, while for SCC cells it was 46.67 × 10-6 m (p = 0.00). AC cell diameter was 13.83 µm,...

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Photodynamic therapy in the upper aerodigestive tract. Overview and outlook

Wed, 23 Mar 2016 23:00:00 +0100

This article aims to present a contemporary and comprehensive review on the role of photodynamic therapy in the treatment of (pre)malignancies of the UADT. PubMed was searched for “photodynamic therapy larynx/oral cavity/oropharynx/head and neck” in 01/2016. PDT can be efficient in the treatment of recurrent, residual or multiple carcinomas of the UADT without other treatment options. It has also been used with success in the treatment of early oral or laryngeal carcinomas, widespread precancerous lesions or “difficult‐to‐treat” skin cancer, even though these treatments are off‐label. For now, unsolved scientific and economical challenges hinder the methods spread. In special cases, PDT is a highly effective method to treat head and neck (pre)malignancies. Nevertheless, furth...



Tigecycline targets non‐small cell lung cancer through inhibition of mitochondrial function

Wed, 23 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)



HNdb: an integrated database of gene and protein information on head and neck squamous cell carcinoma

Wed, 23 Mar 2016 23:00:00 +0100

In this study, we present HNdb, a free database that aims to provide a unified and comprehensive resource of information on genes and proteins involved in HN squamous cell carcinoma, covering data on genomics, transcriptomics, proteomics, literature citations and also cross-references of external databases. Different literature searches of MEDLINE abstracts were performed using specific Medical Subject Headings (MeSH terms) for oral, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinomas. A curated gene-to-publication assignment yielded a total of 1370 genes related to HN cancer. The diversity of results allowed identifying novel and mostly unexplored gene associations, revealing, for example, that processes linked to response to steroid hormone stimulus are significantly enr...



Isolated perifacial lymph node metastasis in oral squamous cell carcinoma with clinically node‐negative neck

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionsIsolated perifacial node metastasis is high in oral squamous cell carcinoma with a clinically node‐negative neck. The incidence of isolated perifacial involvement is high in cases of buccal mucosal and tongue cancers. A meticulous dissection of the perifacial nodes seems prudent when treating the neck in oral cavity squamous cell carcinoma. Level of Evidence4 Laryngoscope, 2016 (Source: The Laryngoscope)



TDG shows antitumor activity by β‐GBP and Treg inhibition in oral squamous cell carcinoma

Wed, 23 Mar 2016 21:07:40 +0100

ConclusionIt appears that TDG, concurrently prevents many tumor promoting effects of β‐GBP in oral cancer cells possibly by Treg inhibition. This offers a preclinical proof of the concept that therapeutic targeting of β‐GBP can overcome Treg mediated tumor promotion and immunosuppression in oral cancer patients.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)

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Low expression of microRNA-202 is associated with the metastasis of esophageal squamous cell carcinoma.

Wed, 23 Mar 2016 14:45:02 +0100

Authors: Ma G, Zhang F, Dong X, Wang X, Ren Y Abstract The present study aimed to determine the expression levels and biological functions of microRNA-202 (miR-202) in patients with esophageal squamous cell carcinoma (ESCC). A total of 60 patients with ESCC and 30 healthy individuals were enrolled and reverse transcription-quantitative polymerase chain reaction was performed to measure the expression levels of miR-202. In order to investigate the effects of miR-202 expression levels on the proliferative, migratory and invasive abilities of ESCC cells, methylthiazolyl-tetrazolium bromide proliferation, in vitro scratch and Transwell® chamber assays were performed. Expression levels of miR-202 were significantly decreased in the peripheral blood of patients with ESCC, which is assoc...



Mixed adenoneuroendocrine carcinoma (MANEC) of the gastroesophageal junction: a case report and review of the literature.

Wed, 23 Mar 2016 12:43:02 +0100

We present a 57-year-old man admitted to the hospital with nausea and vomiting due to a high-grade malignant mixed adenoneuroendocrine carcinoma of the gastroesophageal junction. The patient underwent Ivor-Lewis esophagectomy and adyuvant chemoradiotherapy. At 8-month follow-up he was alive without evidence of recurrence. PMID: 26999428 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)



Acantholytic-Like Pattern in a Recurrent Melanoma Mimicking Acantholytic Squamous Cell Carcinoma: A Further Example Highlighting the Potential for Misdiagnosis

Wed, 23 Mar 2016 04:43:42 +0100

No abstract available (Source: The American Journal of Dermatopathology)



Non-invasive and label-free detection of oral squamous cell carcinoma using saliva surface-enhanced Raman spectroscopy and multivariate analysis

Tue, 22 Mar 2016 23:00:00 +0100

Publication date: Available online 23 March 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Jennifer M. Connolly, Karen Davies, Agne Kazakeviciute, Antony M. Wheatley, Peter Dockery, Ivan Keogh, Malini Olivo Reported here is the application of silver nanoparticle-based surface-enhanced Raman spectroscopy (SERS) as a label-free, non-invasive technique for detection of oral squamous cell cancer (OSCC) using saliva and desquamated oral cells. A total of 180 SERS spectra were acquired from saliva and 120 SERS spectra from oral cells collected from normal healthy individuals and from confirmed oropharyngeal cancer patients. Notable biochemical peaks in the SERS spectra were tentatively assigned to various components. Data were subjected to multivariate statist...



Malignancies in a renal transplant population: The St. Michael's Hospital experience

Tue, 22 Mar 2016 23:00:00 +0100

The objective of this study was to analyze the rate and types of malignancies occurring in the St. Michael's Hospital renal transplant population and to determine whether our results were comparable to those previously published. Methods: After approval by the hospital's research ethic board, review of the records and pathology of the 1584 patients in the renal transplant clinic database patients was performed. The reports dated back to the year 1970. Results: Amongst the 1584 renal transplant patients, 106 patients with 132 dysplastic and malignant posttransplant lesions were identified. The highest incidence amid the malignancies was in nonmelanoma skin malignancies squamous cell carcinoma (SCC), basal cell carcinoma, and Kaposi sarcoma, with a total of 32 patient...

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Changes in Plasma Steroids and Cytokines levels in Betel Chewing Patients in Taiwan

Tue, 22 Mar 2016 23:00:00 +0100

Publication date: Available online 23 March 2016 Source:Steroids Author(s): Sindy Hu, Wen-Chyuan Chen, Guey-Shyang Hwang, Szu-Tah Chen, Song-Bor Kuo, Yifen Chen, Galina Idova, Shyi-Wu Wang Betel nut is the second largest economic food product in Taiwan. In southeast Asia, the habit of chewing betel nut seems to be highly correlated with oral submucous fibrosis and oral squamous cell carcinoma. Oral submucous fibrosis is characterized by abnormal accumulation of oral submucous collagen fibers and limitation of mouth opening. Although the mechanism responsible for tissue damage is still unknown, prolonged irritation caused by betel nut and tobacco is considered to be a major factor contributing to the pathogenesis of oral submucous fibrosis. The effect of betel nut chewing on immun...






Mixed squamous cell and glandular papilloma of the lung resembling early adenocarcinoma: A case report

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion Both pre- and intraoperative diagnoses may be difficult mainly because of the rareness of the disease. The diagnosis of mixed squamous cell and glandular papilloma should be considered in case the presence of adenocarcinoma is not totally ruled out. (Source: Annals of Medicine and Surgery)



FDG-PET Based Differential Uptake Volume Histograms: A Possible Approach Towards Definition of Biological Target Volumes.

Tue, 22 Mar 2016 23:00:00 +0100

CONCLUSION: FDG-based PET data potentially may be used to identify biological target volumes (BTV) within the tumour in NSCLC patients. Using the one-way ANOVA statistical tests we found a significant difference among all threshold levels amongst adenocarcinomas, large cell carcinoma, and squamous cell carcinomas. On the other hand, the observed significant variability in threshold values throughout the patient cohort (expressed as large standard deviations) can be explained as a consequence of differences in the physiological status of the tumour volume for each patient at the time of the PET/CT scan. This further suggests that patient-specific threshold values for definition of BTVs could be determined by creation and curve fitting of dUVHs on a patient-by-patient basis. Advances in know...



Difficult preoperative diagnosis in a case of rapidly progressive carcinomatous pericarditis

Tue, 22 Mar 2016 20:13:19 +0100

Abstract A 54-year-old woman initially diagnosed with stage IIIb squamous cell carcinoma of the uterine cervix was treated with chemotherapy and radiation therapy. After 8 months, she developed dyspnea, leg edema, pleural effusion, pericardial effusion, and liver congestion. Her cardiac ejection fraction was normal and cardiomegaly was not evident. Metastatic carcinomatous pericarditis or pleurisy was suspected, but laboratory findings, including tumor markers, were normal. She was transferred to our hospital for the repair a cardiac injury caused by a pericardial drainage procedure. Emergency surgery was performed for the misplaced drainage catheter in the right atrium and for an abnormal mass in her right and left atria. The clinical diagnosis of carcinomatous pericarditis was...

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Q787Q EGFR Polymorphism as a Prognostic Factor for Lung Squamous Cell Carcinoma

Tue, 22 Mar 2016 05:38:10 +0100

Conclusions: The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II.Oncology (Source: Oncology)



Survival with nonmelanoma skin cancer in Germany

Tue, 22 Mar 2016 00:00:00 +0100

ConclusionsA comprehensive overview of NMSC survival in Germany is provided. The differences between the NMSC subtypes require a more differentiated consideration of patient survival. The survival advantage of patients with BCC may be related to health‐promoting factors related to the BCC diagnosis, such as changes to a healthier lifestyle. (Source: British Journal of Dermatology)



Image Guided Volumetric Response During Chemoradiotherapy for Head and Neck Squamous Cell Carcinoma as a Predictor of Disease Outcomes

Tue, 22 Mar 2016 00:00:00 +0100

Conclusion Patients with locally advanced HNSCC who have significant IGRT volume reduction over the course of definitive CRT tend to have favorable clinical outcomes. (Source: American Journal of Otolaryngology)



Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high‐risk human papilloma virus

Tue, 22 Mar 2016 00:00:00 +0100

Conclusions: The incidence of esophageal papilloma has increased by fourfolds over the past 14 years. About half of the tested patients demonstrated high risk HPV. This may suggest a potential growing risk for esophageal squamous cell cancer in the future. (Source: Diseases of the Esophagus)



Efficacy of docetaxel, cisplatin, and 5‐fluorouracil chemotherapy for superficial esophageal squamous cell carcinoma

Tue, 22 Mar 2016 00:00:00 +0100

Summary The anticancer efficacy of docetaxel, cisplatin, and 5‐fluorouracil (DCF) chemotherapy has been reported to be better than that of conventional regimens for advanced or relapsed esophageal squamous cell carcinoma (ESCC), and may become a standard therapy for this disease. Because it is extremely rare for chemotherapy to be administered as treatment for early cancer alone, the efficacy of DCF for superficial ESCC remains unknown. However, from a clinical oncological standpoint, it is important to investigate the anticancer efficacy of chemotherapy for early cancer, which may be useful for understanding the development of treatment resistance against chemotherapy in cancer. This retrospective, single‐center analysis included 28 patients with superficial ESCC who received DCF for ...

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Circulating miRNAs as novel potential biomarkers for esophageal squamous cell carcinoma diagnosis: a meta‐analysis update

Tue, 22 Mar 2016 00:00:00 +0100

Summary Early detection of esophageal squamous cell carcinoma (ESCC) is urgently needed to reduce the high morbidity and mortality of disease. Circulating microRNAs (miRNAs) are promising molecular biomarkers for ESCC prediction. We performed a comprehensive meta‐analysis to systematically evaluate the diagnostic accuracy of circulating miRNAs in diagnosis of ESCC patients. Eligible studies were identified and assessed for quality employing multiple search strategies. Summary estimates for sensitivity, specificity, and other measures of accuracy of miRNAs in the diagnosis of ESCC were pooled using the bivariate random effects model. A total of 27 studies from 11 published articles were included in the meta‐analysis. The overall sensitivity, specificity, positive likelihood ratio, negat...



Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Tue, 22 Mar 2016 00:00:00 +0100

Smoking and betel nut chewing are well-known risk factors for head and neck squamous cell carcinoma (HNSCC). Smoking is also a strong prognosticator for patients with locally advanced HNSCC receiving induction... (Source: World Journal of Surgical Oncology)



Q787Q EGFR Polymorphism as a Prognostic Factor for Lung Squamous Cell Carcinoma.

Mon, 21 Mar 2016 23:00:00 +0100

CONCLUSIONS: The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II. PMID: 26999786 [PubMed - as supplied by publisher] (Source: Oncology)



Skin Cancer Incidence and Mortality in Spain: A Systematic Review and Meta-Analysis

Mon, 21 Mar 2016 23:00:00 +0100

Conclusions The registration methodology normally used by cancer registries probably underestimates the incidence rates of basal cell and squamous cell carcinoma in Spain. The incidence rates of cutaneous melanoma and Merkel cell carcinoma are lower in Spain than in other European countries. (Source: Actas Dermo-Sifiliograficas)



Impact of p16 expression, nodal status, and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma

Mon, 21 Mar 2016 23:00:00 +0100

ConclusionAmong patients with CUP, p16‐positive status is an independent predictor of DFS but not overall survival (OS). © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)

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Human papillomavirus integration pattern and demographic, clinical, and survival characteristics of patients with oropharyngeal squamous cell carcinoma

Mon, 21 Mar 2016 23:00:00 +0100

ConclusionThe majority of HPV‐positive oropharyngeal SCCs have either integrated or both episomal and integrated HPV with no significant differences in survival among the groups. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



Correlation Between Cyclo-oxygenase-2 and Vascular Endothelial Growth Factor Expression in Canine and Feline Squamous Cell Carcinomas

Mon, 21 Mar 2016 23:00:00 +0100

Publication date: Available online 21 March 2016 Source:Journal of Comparative Pathology Author(s): F. Millanta, G. Andreani, G. Rocchigiani, D. Lorenzi, A. Poli Overexpression of cyclo-oxygenase (COX)-2 is involved in tumour growth and spread by modulating the production of angiogenic factors such as vascular endothelial growth factor (VEGF). Expression of COX-2 and VEGF was investigated immunohistochemically in 51 canine and feline cutaneous and non-cutaneous squamous cell carcinomas (SCCs) and the correlation between expression of these molecules and clinicopathological variables was evaluated. COX-2 and VEGF expression was not observed in normal skin keratinocytes. COX-2 overexpression occurred in 53% and 61% of the canine and feline SCCs, respectively. The expression of both ma...



Id: 38: primary squamos cell carcinoma of the rectum

Mon, 21 Mar 2016 23:00:00 +0100

In conclusion, SCC of rectum is a distinct entity and it is important to shed some light on this rare condition because it has different epidemiology, etiology, pathogenies and requires a different treatment approach than other colorectal carcinomas. Surgery is the primary treatment which consists of local excision versus radical resection and the need for adjuvant therapy. Abstract ID: 38 Figure 1 (Source: Journal of Investigative Medicine)



Non-invasive and label-free detection of oral squamous cell carcinoma using saliva surface-enhanced Raman spectroscopy and multivariate analysis

Mon, 21 Mar 2016 23:00:00 +0100

Reported here is the application of silver nanoparticle-based surface-enhanced Raman spectroscopy (SERS) as a label-free, non-invasive technique for detection of oral squamous cell cancer (OSCC) using saliva and desquamated oral cells. A total of 180 SERS spectra were acquired from saliva and 120 SERS spectra from oral cells collected from normal healthy individuals and from confirmed oropharyngeal cancer patients. Notable biochemical peaks in the SERS spectra were tentatively assigned to various components. (Source: Nanomedicine : Nanotechnology, Biology, and Medicine)



IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma

Mon, 21 Mar 2016 23:00:00 +0100

Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Dysregulation of SOCS protein expression in cancers can be one of the mechanisms that maintain STAT activation, but this mechanism is still poorly understood in oral squamous cell carcinoma (OSCC). Here, we report that SOCS2 protein is significantly downregulated in OSCC patients and its levels are inversely correlated with miR-424-5p expression. (Source: Molecular Oncology)

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CheckMate 057: Improved Survival with Nivolumab vs Docetaxel in Patients With Advanced Nonsquamous NSCLC After Platinum-Based Doublet Chemotherapy

Mon, 21 Mar 2016 12:00:00 +0100

JO Capsule - The benefit of nivolumab was significantly associated with tumor PD-L1 expression, unlike in squamous cell NSCLC, in which there was no association between PD-L1 expression and nivolumab efficacy. (Source: Clinical Care Options Lung Cancer)



Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer

Mon, 21 Mar 2016 12:00:00 +0100

Journal Article - (Source: Clinical Care Options Lung Cancer)



CheckMate 017: Improved Survival With Nivolumab vs Docetaxel in Patients With Advanced Squamous Cell NSCLC After Platinum-Containing Chemotherapy

Mon, 21 Mar 2016 12:00:00 +0100

JO Capsule - The efficacy benefit of nivolumab was observed across all PD-L1 expression levels, unlike in nonsquamous NSCLC, in which there was an association between PD-L1 expression and nivolumab efficacy. (Source: Clinical Care Options Lung Cancer)



[Is (chemo)radiotherapy really the future standard in the treatment of oropharyngeal carcinoma?]

Mon, 21 Mar 2016 10:54:03 +0100

Authors: Knecht R, Bussmann L, Möckelmann N, Lörincz BB Abstract Treatment of patients with oropharyngeal squamous cell carcinoma (OPSCC) requires interdisciplinary collaboration. Besides oncologic control, organ and function preservation are important priorities. One treatment option is primary concomitant chemoradiotherapy (CRT), particularly for locally advanced head and neck cancer. Another option is sequential CRT, where induction chemotherapy may be followed either by radiation alone or by CRT. An important aspect of these modalities is the development of functional sequelae with regards to swallowing as a direct consequence of radiogenic fibrosis, as well as tissue ctoxicity associated with cisplatin-based chemotherapy. Conventional open surgical approaches are being incr...



Novel circulating peptide biomarkers for esophageal squamous cell carcinoma revealed by a magnetic bead-based MALDI-TOFMS assay.

Mon, 21 Mar 2016 05:47:03 +0100

In conclusion, the newly established circulating peptide panel and identified proteins could serve as potential biomarkers for the early detection and diagnosis of ESCC. Nevertheless, a larger cohort will be required for further unequivocal validation of their clinical application. PMID: 26993605 [PubMed - as supplied by publisher] (Source: Oncotarget)

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Prognostic value of glucosylceramide synthase and P-glycoprotein expression in oral cavity cancer

Mon, 21 Mar 2016 00:00:00 +0100

Conclusion GCS and P-gp expression is associated with poor prognosis, suggesting suitability as novel biomarkers in OSCC. (Source: International Journal of Clinical Oncology)



Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus

Mon, 21 Mar 2016 00:00:00 +0100

Human papillomavirus (HPV) type 16 (HPV 16) plays an etiologic role in the majority of cases of squamous cell carcinoma of the oropharynx (SCCOP), particularly those occurring in middle-aged patients and patients with no smoking history [1–6]. Chaturvedi et al., in an analysis of US incidence trends for oral cavity and oropharynx cancers stratified by age, demonstrated that the incidence of squamous cell carcinoma of the oral cavity (SCCOC) decreased overall but increased significantly among adults younger than 40years, consistent with an increasing incidence of SCCOP across age groups [6]. (Source: Oral Oncology)



MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report.

Sun, 20 Mar 2016 23:00:00 +0100

Authors: Kageyama S, Kanoto M, Sugai Y, Suto T, Nagase S, Osakabe M, Hosoya T Abstract Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm of chorionic-type intermediate trophoblasts, and it is most frequently located in the lower uterine segment and endocervix. Due to the epithelial-growth pattern with geographic necrosis exhibited by the neoplastic cells, ETT is commonly confused, both clinically and pathologically, with squamous cell carcinoma. Although there have been no previous reports of ETT focusing on computed tomography (CT) or magnetic resonance imaging (MRI) findings, we report a case of uterine ETT with special attention to the MRI findings referring to the pathological findings and MR images of previous reports. A 42-year-old Japanese wo...



HPV prevalence and p16INKa overexpression in non smoking non drinking oral cavity cancer patients

Sun, 20 Mar 2016 09:34:07 +0100

ConclusionsNSND are a specific population of OCSCC patients. In contrast to oropharyngeal cancer, HPV and p16 expression in OCSCC are negative predictive factors, especially in NSND patients.This article is protected by copyright. All rights reserved. (Source: Oral Diseases)



Toxicities Following Stereotactic Ablative Radiotherapy Treatment of Locally-Recurrent and Previously Irradiated Head and Neck Squamous Cell Carcinoma

Sun, 20 Mar 2016 06:19:41 +0100

Stereotactic ablative radiotherapy (SABR) with concomitant cetuximab is an effective treatment option for previously irradiated, locally recurrent squamous cell carcinoma of the head and neck. Its local control and overall survival are similar to those of other available treatment options. Each retreatment depends heavily on the prior treatment and every patient is a special case. Based on the experience of our institution and previously published studies, for patients who receive concomitant cetuximab with a median prior radiation therapy dose of 70Gy, we recommend a total dose of 40-44Gy delivered in 5 fractions on alternating days over 1-2 weeks. (Source: Seminars in Radiation Oncology)

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A 10-year review of outpatient skin biopsy results and skin cancer subtypes.

Sun, 20 Mar 2016 01:46:01 +0100

Authors: DeMarco SS, Vos P, Green H, Defazio J, Davis N, Fiz L, Phillips C Abstract The results of skin biopsies over a 10 year period were reviewed from the outpatient dermatology clinic at the Brody School of Medicine in Greenville, North Carolina. This research was conducted because there are very few studies that characterize this information over a long-term horizon. The biopsy rate per patient encounter, the clinical reason for the biopsy, the biopsy outcomes, the distribution of cutaneous malignancies per encounter, and the distribution of the subtypes of basal cell carcinoma, squamous cell carcinoma, and melanoma were analyzed. Biopsy logs from January 1, 2001 to December 31, 2010 were reviewed. Our investigation found that 20% of patient encounters resulted in a biopsy. Of...



Polycarboxylate ethers: The key towards non-toxic TiO2 nanoparticle stabilisation in physiological solutions

Sun, 20 Mar 2016 00:00:00 +0100

In this study self-synthesised TiO2 NPs were stabilised in three different cell culture media (DMEM, RPMI, BEGM) with the help of stabilising agents. Cell culture tested stabilisers (bovine serum albumin, fetal bovine serum) were compared to non-tested commercial products which are commonly utilized in the cement industry (Melflux® 4930 F, Melpers® 4343, Sika® ViscoCrete®-10110178). For a quantitative evaluation and comparison of the degree of stabilisation, a sedimentation study using UV absorbance spectroscopy was carried out and the agglomerate size was measured via dynamic light scattering. The cytotoxicity of the novel surfactants and stabilised NPs was examined in a head and neck squamous cell carcinoma-derived FaDu cell line and in human mesenchymal stem cells. We successfully s...



Skin toxicity in BRAF(V600) mutated metastatic cutaneous melanoma patients treated with vemurafenib.

Sat, 19 Mar 2016 21:41:02 +0100

CONCLUSIONS: The incidence of squamous cell carcinoma was high (38%). This study has many limitations mostly due to a small group of patients. That is why the results should be taken into consideration with caution. The proper symptomatic treatment in cooperation with dermatologists allows to continue the vemurafenib therapy. PMID: 26985180 [PubMed] (Source: Advances in Dermatology and Allergology)



Predictive Value of Plasma MicroRNA-216a/b in the Diagnosis of Esophageal Squamous Cell Carcinoma.

Sat, 19 Mar 2016 19:51:02 +0100

Authors: Dong S, Yin H, Dong C, Sun K, Lv P, Meng W, Ming L, He F Abstract Esophageal squamous cell carcinoma (ESCC) is a common human malignancy with poor survival, which was usually diagnosed at an advanced stage. MicroRNAs (miRNAs), a class of single stranded noncoding RNAs with only 17-25 ribonucleotides, were demonstrated to play an important role in lots of cancers. In the recent years, increasing evidence revealed that circulating miRNAs exhibited great potential in the diagnosis of various types of cancers. The present study was designed to evaluate the diagnostic value of plasma miRNA-216a/b for ESCC. Our results showed that the expression level of plasma miRNA-216a/b was significantly lower in ESCC patients compared with that of healthy controls. The receiver operating ch...



ADAM10 mediates the cell invasion and metastasis of human esophageal squamous cell carcinoma via regulation of E-cadherin activity.

Sat, 19 Mar 2016 17:53:03 +0100

In conclusion, active ADAM10 promotes the carcinogenesis, invasion, metastasis and proliferation of ESCC and controls invasion and metastasis at least in part through the shedding of E-cadherin activity, which makes it a potential biomarker and a useful therapeutic target for ESCC. PMID: 26986985 [PubMed - as supplied by publisher] (Source: Oncology Reports)

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Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene.

Sat, 19 Mar 2016 17:53:03 +0100

Authors: Ito T, Ozaki S, Chanasong R, Mizutani Y, Oyama T, Sakurai H, Matsumoto I, Takemura H, Kawahara E Abstract In order to investigate the involvement of the IER3/PP2A-B56γ/ERK-positive feedback loop, which leads to sustained phosphorylation/activation of ERK in carcinogenesis, we immunohistochemically examined the expression of IER3 and phosphorylated ERK in lung tumor tissues. IER3 was overexpressed in all cases of adenocarcinomas examined, but was not overexpressed in squamous cell carcinomas. Phosphorylated ERK (pERK) was also overexpressed in almost all adenocarcinomas. EGFR and RAS, whose gene product is located upstream of ERK, were sequenced. Activating mutation of EGFR, which is a possible cause of overexpression of IER3 and pERK, was found only in 5 adenocarcinomas (...



Development of a high-resolution melting method for the screening of TNFAIP3 gene mutations.

Sat, 19 Mar 2016 17:53:03 +0100

Authors: Chang YC, Chang YS, Chang CC, Liu TC, Ko YC, Lee CC, Chang SJ, Chang JG Abstract Tumor necrosis factor, α-induced protein 3 (TNFAIP3) which encodes a ubiquitin-modifying enzyme (A20), acts as a negative regulator of the NF-κB pathway, and in lymphoma and autoimmune diseases it is frequently inactivated by mutations and/or deletions. We investigated the prevalence of the inactivation of TNFAIP3 in oral squamous cell carcinoma (OSCC). DNA was extracted from 81 cases of OSCC and 50 peripheral blood samples from normal controls. A high-resolution melting (HRM) analysis was used to characterize TNFAIP3 mutations, and the results were confirmed by direct DNA sequencing. Three mutations and three single-nucleotide polymorphisms (SNPs) were found to be associated with OSCC; th...



Prostate tumor overexpressed-1 in conjunction with human papillomavirus status, predicts outcome in early-stage human laryngeal squamous cell carcinoma.

Sat, 19 Mar 2016 17:51:03 +0100

Authors: Yang L, Wang H, Wang Y, He Z, Chen H, Liang S, He S, Wu S, Song L, Chen Y Abstract In human cancer, molecular markers combined with clinical characteristics are used increasingly to predict prognosis. Prostate tumor overexpressed-1 (PTOV1), first identified in prostate cancer, is a key factor in tumor progression and correlates with unfavorable clinical outcomes. HPV infection status was tested by HPV E6-targeted multiplex real-time PCR and p16 immunohistochemistry (IHC). Real-time PCR and western blotting analyses were used to examine the mRNA and protein expression levels of PTOV1 in eight paired LSCC samples. IHC was performed to assess PTOV1 protein expression in 196 paraffin-embedded, archived LSCC samples. PTOV1 protein and mRNA expression was increased in LSCC tissu...



DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase.

Sat, 19 Mar 2016 17:51:03 +0100

Authors: Srinivas KP, Viji R, Dan VM, Sajitha IS, Prakash R, Rahul PV, Santhoshkumar TR, Lakshmi S, Pillai MR Abstract DEPTOR is an endogenous inhibitor of mTOR complexes, de-regulated in cancers. The present study reveals a vital role for DEPTOR in survival of cervical squamous cell carcinoma (SCC). DEPTOR was found to be overexpressed in both cervical SCC cells and tissues and it's silencing in cervical SCC cells induced apoptosis, mainly by up-regulation of p38 MAPK and by inhibiting PI3K/AKT pathway via a feed-back inhibition from mTORC1-S6K. DEPTOR silencing resulted in reduced expression of the nitric oxide synthases iNOS and eNOS, as well as increased activation of ERK1/2 and p38 MAP kinases. Activation of AKT signaling by overexpression of constitutively active-AKT (CA-AKT)...



Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients.

Sat, 19 Mar 2016 17:51:03 +0100

In conclusion, TMPRSS4 is a novel independent prognostic biomarker regulated by epigenetic changes in SCC and a potential therapeutic target in this tumor type, where targeted therapy is still underdeveloped. PMID: 26989022 [PubMed - as supplied by publisher] (Source: Oncotarget)

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Vasculogenic mimicry and hypoxia-inducible factor-1α expression in cervical squamous cell carcinoma.

Sat, 19 Mar 2016 03:01:03 +0100

In this study, the existence of vasculogenic mimicry (VM) in cervical squamous cell carcinoma was investigated. To this end, the relationship between hypoxia-inducible factor 1α (HIF-1α) and the development, infiltration, and metastasis of cervical squamous cell carcinoma was studied. Between January 2010 and December 2010, 67 human cervical squamous carcinoma tissue samples were collected and stained by CD34/periodic acid-Schiff double staining to detect the existence of VM. HIF-1α expression was analyzed by immunohistochemistry. The relationship between VM and HIF-1α was also analyzed. Normal cervical tissues (20 cases) from patients who had uterine surgeries in the same period were collected as controls. In the cervical squamous carcinoma tissues, positive rates of VM and HIF-1α we...



Development of a Squamous Cell Carcinoma of the Hand and Wrist after Cardiac Transplantation

Sat, 19 Mar 2016 00:00:00 +0100

Described are the findings in a 57-year-old man who developed a large carcinoma 2 years post heart transplantation. Mental anxiety or depression may have contributed to a delay in seeking medical care. The result was amputation of the right arm below the elbow. (Source: The American Journal of Cardiology)



Significance of endothelial progenitor cells (EPC) for tumorigenesis of head and neck squamous cell carcinoma (HNSCC): possible marker of tumor progression and neovascularization?

Sat, 19 Mar 2016 00:00:00 +0100

Conclusions Our findings indicate a possible pathway for EPC to play a critical role in the vasculogenesis and consequently in the progression of HNSCC. Clinical Relevance. Our findings could serve as possible predictors for the neovascularisation potential in HNSCC tumor patients. (Source: Clinical Oral Investigations)



PIK3CA promotes proliferation and motility but is unassociated with lymph node metastasis or prognosis in esophageal squamous cell carcinoma

Sat, 19 Mar 2016 00:00:00 +0100

The PIK3CA mutation has been extensively reported in the setting of cancers; however, the clinicopathologic significance of PIK3CA expression has rarely been discussed in esophageal squamous cell carcinoma (ESSC). In the present study, to confirm the significance of PIK3CA expression in association with metastasis and prognosis, which has been somewhat controversial in ESCC, the relationship between clinicopathologic features of ESCC and PIK3CA expression was analyzed using immunohistochemistry with a tissue microarray. (Source: Human Pathology)



A phase II, open-label trial of bortezomib (VELCADE ® ) in combination with gemcitabine and cisplatin in patients with locally advanced or metastatic non-small cell lung cancer

Fri, 18 Mar 2016 23:00:00 +0100

Conclusion The incorporation of bortezomib into the gemcitabine/cisplatin regimen, in the dose and schedule used in this study, could not improve the efficacy of the chemotherapy regimen and has not to be further investigated. (Source: Cancer Chemotherapy and Pharmacology)

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Secondary bone marrow malignancies after adjuvant chemotherapy for breast cancer: a report of 2 cases and a review of the literature.

Fri, 18 Mar 2016 12:25:02 +0100

CONCLUSIONS: By literature review, these 2 cases do not support the relationship between primary tumor treatment and secondary cancer, but strongly suggest the need for histologic samples when bone metastasis occurred after years from diagnosis of breast cancer. In this setting, the oncologist should take into account a secondary bone marrow tumor before starting treatment for breast cancer. PMID: 26979247 [PubMed - as supplied by publisher] (Source: Tumori)



Safety of combination treatment with imatinib mesylate, carboplatin, and cetuximab in a patient with multiple cancers: a case report.

Fri, 18 Mar 2016 12:25:02 +0100

CONCLUSIONS: Our report indicates the feasibility of combination imatinib and cetuximab plus carboplatin in a case of multiple cancer diagnoses, provided that the treatment with imatinib is modulated according to the expected bone marrow depression. PMID: 26979243 [PubMed - as supplied by publisher] (Source: Tumori)



Development of a new outcome prediction model for Chinese patients with penile squamous cell carcinoma based on preoperative serum C-reactive protein, body mass index, and standard pathological risk factors: the TNCB score group system.

Fri, 18 Mar 2016 05:56:02 +0100

CONCLUSION: The present study demonstrated that the TNCB score group system maybe a precise and easy to use tool for predicting outcomes in Chinese penile squamous cell carcinoma patients. PMID: 26980738 [PubMed - as supplied by publisher] (Source: Oncotarget)



Immunogenic cell death by oncolytic herpes simplex virus type 1 in squamous cell carcinoma cells

Fri, 18 Mar 2016 00:00:00 +0100

Authors: A Takasu, A Masui, M Hamada, T Imai, S Iwai & Y Yura (Source: Cancer Gene Therapy)