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MedWorm: Melanoma



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Melanoma category.



Last Build Date: Tue, 29 Mar 2016 16:47:27 +0100

 



Plasma cells in primary melanoma. Prognostic significance and possible role of IgA

Mon, 28 Mar 2016 22:00:00 +0100

Authors: Francesca M Bosisio, James S Wilmott, Nathalie Volders, Marjorie Mercier, Jasper Wouters, Marguerite Stas, Willeke AM Blokx, Daniela Massi, John F Thompson, Richard A Scolyer, Nicolas van Baren & Joost J van den Oord (Source: Modern Pathology)

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The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing

Mon, 28 Mar 2016 22:00:00 +0100

Authors: Gang Wu, Raymond L Barnhill, Seungjae Lee, Yongjin Li, Ying Shao, John Easton, James Dalton, Jinghui Zhang, Alberto Pappo & Armita Bahrami (Source: Modern Pathology)



Lion Biotechnologies Names Michael T. Lotze Chief Scientific Officer

Mon, 28 Mar 2016 21:30:01 +0100

NEW YORK, NY--(Healthcare Sales & Marketing Network) - Lion Biotechnologies, Inc. (LBIO), a biotechnology company that is developing novel cancer immunotherapies based on tumor-infiltrating lymphocytes (TIL), today announced the appointment of Michael T. L... Biopharmaceuticals, Oncology, PersonnelLion Biotechnologies, melanoma (Source: HSMN NewsFeed)



Pd28-12 a phase 1 study of a third-generation oncolytic hsv-1 g47Δ in patients with castration resistant prostate cancer

Mon, 28 Mar 2016 19:24:10 +0100

Oncolytic herpes simplex viruses type 1 (HSV-1) is an attractive therapeutic agent for treating cancer due to its capacity to selectively replicate in cancer cells, kill them, and spread their progeny to surrounding cancer cells. Recently, FDA approved IMLYGIC™ (Talimogene laherparepvec) as the first oncolytic virus drug in developed countries. IMLYGIC is a second-generation oncolytic HSV-1 that showed a higher durable response rate and a better overall survival in the group of advanced malignant melanoma patients than the control group. (Source: The Journal of Urology)



Mp61-12 new targets for immune checkpoint inhibition in urothelial carcinoma

Mon, 28 Mar 2016 19:24:08 +0100

Tumor cells evade immune surveillance by expressing cell surface ligands such as PD-L1 that are known to disrupt normal T cell function. Inhibition of these immunologic checkpoints has led to durable clinical remissions in metastatic melanoma, lung cancer, and bladder cancer. Zang et al. have recently described new checkpoint family members (HHLA2 and B7x) that appear to play a significant role in T-cell regulation. We sought to determine whether these newly described ligands are expressed in human urothelial carcinoma. (Source: The Journal of Urology)



Mp70-04 melanoma antigen protein magec1 mutation identified in familial non-obstructive azoospermia

Mon, 28 Mar 2016 19:24:06 +0100

Many currently unrecognized genetic etiologies of male infertility exist, and we sought to identify genes influencing male infertility using next-generation sequencing approaches. The melanoma antigen (MAGE) family of genes may function in germ cell maintenance and fertility, and herein we present genomic data associating the melanoma antigen gene MAGEC1 with male fertility. (Source: The Journal of Urology)

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V10-12 robotic bladder neck closure and mitrofanoff

Mon, 28 Mar 2016 19:24:05 +0100

Complex urologic reconstruction may be required after morbid cancer operations. Well documented advantages of robotic surgery can be utilized during these reconstructive cases including shorter hospital stay and improved cosmesis. This video demonstrates a robotic bladder neck closure and appendicovesicostomy after radical vaginectomy and urethrectomy in a female with vulvar melanoma. (Source: The Journal of Urology)



V11-12 robotic adrenalectomy for metastatic melanoma

Mon, 28 Mar 2016 19:24:04 +0100

Due to the delicacy of some particular pathologies, there are some disease states that urologist can provide a service in non urologic malignancies. A minimally invasive adrenalectomy for metastatic melanoma with hemorrhage is a procedure not commonly performed. However, adrenal metastasis is present in 50% of Stage IV melanoma. The robotics trained urologists can provide minimally invasive procedure for Stage IV melanoma. (Source: The Journal of Urology)



Melanoma and Pregnancy: A Deadly Combo

Mon, 28 Mar 2016 15:38:45 +0100

CLEVELAND, Ohio. (Ivanhoe Newswire) – Every 57 minutes, someone dies of melanoma. It’s the deadliest skin cancer and it’s on the rise. Now, researchers are linking melanoma and pregnancy. Here are more details on what moms-to-be need to know. (Source: Medical Headlines From Ivanhoe.com)



Plasma Therapy: No New Knees Needed

Mon, 28 Mar 2016 05:00:00 +0100

SALT LAKE CITY. (Ivanhoe Newswire) -- The FDA says about 74,000 Americans were diagnosed with melanoma, a type of skin cancer. Last year, nearly 10,000 of them died of it. Now, researchers have a new weapon in their arsenal; one that comes from a genetically-altered herpes virus. Here’s more about the first cancer-killing viral therapy ever approved in the U.S. (Source: Medical Headlines From Ivanhoe.com)



Primary Multifocal Malignant Melanoma of Esophagus Co-Occurs With Esophagogastric Junction Adenocarcinoma

Sun, 27 Mar 2016 22:00:00 +0100

Authors: Yu-Bin Zhou, Yong Yuan, Bing Hu & Guo-Wei Che (Source: The American Journal of Gastroenterology)

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Paraconsistent analysis network applied in the treatment of Raman spectroscopy data to support medical diagnosis of skin cancer

Sun, 27 Mar 2016 22:00:00 +0100

Abstract Paraconsistent logic (PL) is a type of non-classical logic that accepts contradiction as a fundamental concept and has produced valuable results in the analysis of uncertainties. In this work, algorithms based on a type of PL—paraconsistent annotated logic of two values (PAL2v)—are interconnected into a network of paraconsistent analysis (PANnet). PANnet was applied to a dataset comprising 146 Raman spectra of skin tissue biopsy fragments of which 30 spectra were determined to represent normal skin tissue (N), 96 were determined to represent tissue with basal cell carcinoma, and 19 were determined to be tissue with melanoma (MEL). In this database, paraconsistent analysis was able to correctly discriminate 136 out of a total of 145 fragments, obtaining a 93.793 % cor...



Identification of anti‐cancer chemical compounds using Xenopus embryos

Sun, 27 Mar 2016 22:00:00 +0100

This study examined Xenopus embryonic tissues to identify anti‐cancer compounds that prevent cancer invasion. From the initial test of known anti‐cancer drugs, AMD3100 (an inhibitor of CXCR4) and Paclitaxel (a cytoskeletal drug targeting microtubules) effectively prevented migration during gastrulation or CNCCs development. Blind‐screening of 100 synthesized chemical compounds was performed, and nine candidates that inhibited migration of these embryonic tissues without embryonic lethality were selected. Of these, C‐157 (an analog of podophyllotoxin) and D‐572 (which is an indole alkaroid) prevented cancer cell invasion through disruption of interphase microtubules. In addition, these compounds affected progression of mitotic phase and induced apoptosis of SAS oral cancer cells. ...



Need for Sun cream with your manicure? - Dangers of UV nail dryers

Sun, 27 Mar 2016 22:00:00 +0100

Over 102,000 cases of non-melanoma skin cancer (NMSC) were reported in 2011 with rates growing annually.1 The main NMSC is basal cell carcinoma accounting for 75%, with others including squamous cell carcinoma. It has been estimated that 90% of NMSC originates from exposure to UV light; which initiates malignant transformation in keratinocytes and reduces the protective inflammatory and immune.2 The increasing incidence has been attributed to an ageing population, rises in recreational activity associated with skin exposure, and use of sunbeds. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)



Diagnosis and Management of Pigmented Skin Lesions Using Teledermatology

Sun, 27 Mar 2016 22:00:00 +0100

This article reviews the literature that evaluates teledermatology’s use for the diagnosis and management of pigmented skin lesions. While the current evidence does not provide conclusive results, it does suggest inferior diagnostic accuracy for pigmented skin lesions when teledermatology has been directly compared to an in-person dermatologist’s examination. Teledermoscopy, the use of dermoscopy for telemedicine applications, has been shown to improve the diagnostic accuracy and reliability of telemedicine. The literature is limited by small sample sizes, in particular as it relates to melanoma, indicating the need for further study to provide more clarity regarding teledermatology’s use for pigmented lesions. (Source: Current Dermatology Reports)



Caspase dependent apoptotic inhibition of melanoma and lung cancer cells by tropical Rubus extracts

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): Blassan Plackal Adimuriyil George, Heidi Abrahamse, Nanjundaswamy M. Hemmaragala Rubus fairholmianus Gard. inhibits human melanoma (A375) and lung cancer (A549) cell growth by the caspase dependent apoptotic pathway. Herbal products have a long history of clinical use and acceptance. They are freely available natural compounds that can be safely used to prevent various ailments. The plants and plant derived products became the basis of traditional medicine system throughout the world for thousands of years. The effects of R. fairholmianus root acetone extract (RFRA) on the proliferation of A375 and A549 cells was examined in this study. RFRA led to a decrease in cell viability, proliferation ...

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Advances in cancer immunology and cancer immunotherapy.

Sat, 26 Mar 2016 21:34:04 +0100

The objective clinical response observed in patients treated with antibodies that block the immune checkpoints, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell-death protein 1 (PD-1)/programmed cell-death 1 ligand 1 (PD-L1) pathways, has led to their FDA approval for the treatment of melanoma in 2011 and in 2014, respectively. The anti-PD-1 antibody nivolumab has received the FDA-approval in March 2015 for squamous lung cancer treatment. In addition, antibodies targeting PD-1 or PD-L1 have demonstrated their efficacy and safety in additional tumors, including non-small cell lung carcinoma (NSCLC), renal cell carcinoma (RCC), bladder cancer, and Hodgkin's lymphoma. Almost at the same time, the field of adoptive cell transfer has exploded. The chimeric antigen recept...



Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: The absence of differences in survival between hand-acral melanoma and foot-acral melanoma shows that the aggressiveness of the disease is related to distinct mutational rate, as well as to anatomical site-specific features, rather than to the visibility of the primary lesion. PMID: 27010139 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)



Cutaneous melanoma in octogenarians: a single-institution review.

Sat, 26 Mar 2016 10:49:01 +0100

CONCLUSIONS: In our octogenarians, death for CM was not related to the old age but to the delayed diagnosis of cancer. Our results suggest that continuing educational programs for early diagnosis of CM should specifically include this segment of population. PMID: 27013147 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)



Cory Watson Attorneys Reports New Developments in Litigation Involving...

Sat, 26 Mar 2016 09:07:01 +0100

Attorneys representing plaintiffs in the Viagra melanoma litigation are preparing for court hearings March 31(PRWeb March 25, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13293703.htm (Source: PRWeb: Medical Pharmaceuticals)



Cancer is more effectively targeted 'when drugs are delivered directly to skin'

Fri, 25 Mar 2016 22:05:08 +0100

A team of North Carolina scientists developed a skin patch that delivers cancer immunotherapy treatment directly to the site of a melanoma through microneedles filled with antibodies. (Source: the Mail online | Health)

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Could a skin PATCH treat melanoma? Slowly releasing anti-cancer drugs directly on to tumor 'eradicates the deadly disease'

Fri, 25 Mar 2016 20:28:53 +0100

A team of North Carolina scientists developed a skin patch that delivers cancer immunotherapy treatment directly to the site of a melanoma through microneedles filled with antibodies. (Source: the Mail online | Health)



Hypoxia-regulated gene expression explains differences between melanoma cell line-derived xenografts and patient-derived xenografts.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Bhadury J, Einarsdottir BO, Podraza A, Olofsson Bagge R, Stierner U, Ny L, Dávila López M, Nilsson JA Abstract Cell line-derived xenografts (CDXs) are an integral part of drug efficacy testing during development of new pharmaceuticals against cancer but their accuracy in predicting clinical responses in patients have been debated. Patient-derived xenografts (PDXs) are thought to be more useful for predictive biomarker identification for targeted therapies, including in metastatic melanoma, due to their similarities to human disease. Here, tumor biopsies from fifteen patients and ten widely-used melanoma cell lines were transplanted into immunocompromised mice to generate PDXs and CDXs, respectively. Gene expression profiles generated from the tumors of these PDXs and CDX...



Ascophyllan functions as an adjuvant to promote anti-cancer effect by dendritic cell activation.

Fri, 25 Mar 2016 17:33:04 +0100

In this study, we evaluated ascophyllan as an adjuvant for its therapeutic and preventive effect on tumor in a mouse melanoma model. Ascophyllan induced migration of DCs to spleen and tumor-draining lymph node (drLN) in a mouse B16 melanoma model. Moreover, ascophyllan induced activation of dendritic cells (DCs), and promoted IFN-γ- and TNF-α-producing Th1 immune responses in tumor-bearing mice. In addition, treatment with a combination of ascophyllan and ovalbumin (OVA) in the tumor-bearing mice promoted proliferation of OVA-specific CD4 and CD8 T cells and migration of those cells into the tumor, consequently inhibiting the tumor growth. Immunization with the combination of ascophyllan and OVA caused enhanced OVA-specific antibody production and memory T cell responses compared to OVA ...



Copy number variation in archival melanoma biopsies versus benign melanocytic lesions.

Fri, 25 Mar 2016 15:40:03 +0100

CONCLUSIONS: Taken together, these findings can help improve melanoma diagnosis and introduce novel melanoma therapeutic targets. PMID: 27002761 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)



Hepatic Perfusion Therapy

Fri, 25 Mar 2016 15:35:28 +0100

Isolated hepatic perfusion uses the unique vascular supply of hepatic malignancies to deliver cytotoxic chemotherapy. The procedure involves vascular isolation of the liver and delivery of chemotherapy via the hepatic artery and extraction from retrohepatic vena cava. Benefits of hepatic perfusion have been observed in hepatic metastases of ocular melanoma and colorectal cancer and primary hepatocellular carcinoma. Percutaneous and prophylactic perfusions are avenues of ongoing research. (Source: Surgical Clinics of North America)

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Patch delivers immunotherapy to site of melanoma skin cancer

Fri, 25 Mar 2016 15:35:21 +0100

Stephen FellerRALEIGH, N.C., March 25 (UPI) -- Delivering immunotherapy drugs directly to melanoma skin cancer sites was more effective at fighting the disease than injecting them, according to researchers. (Source: Health News - UPI.com)



Treating Melanoma Brain Mets With Radiation and NivolumabTreating Melanoma Brain Mets With Radiation and Nivolumab

Fri, 25 Mar 2016 12:34:28 +0100

Is stereotactic radiation to melanoma brain metastases tolerated well in patients who received nivolumab? Annals of Oncology (Source: Medscape Today Headlines)



[Report] Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Thu, 24 Mar 2016 23:00:00 +0100

As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intratumor heterogeneity (ITH) on antitumor immunity. Through integrated analysis of ITH and neoantigen burden, we demonstrate a relationship between clonal neoantigen burden and overall survival in primary lung adenocarcinomas. CD8+ tumor-infiltrating lymphocytes reactive to clonal neoantigens were identified in early-stage non–small cell lung cancer and expressed high levels of PD-1. Sensitivity to PD-1 and CTLA-4 blockade in patients with advanced NSCLC and melanoma was enhanced in tumors enriched for clonal neoantigens. T cells recognizing clonal neoantigens were detectable in patients with durable clini...



Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

Thu, 24 Mar 2016 23:00:00 +0100

We report a key role of type I interferons (IFNs) in oncogene-induced senescence. IFN signaling-deficient melanocytes expressing activated Braf do not exhibit senescence and develop aggressive melanomas. Restoration of IFN signaling in IFN-deficient melanoma cells induces senescence and suppresses melanoma progression. Additional data from human melanoma patients and mouse transplanted tumor models suggest the importance of non-cell-autonomous IFN signaling. Inactivation of the IFN pathway is mediated by the IFN receptor IFNAR1 downregulation that invariably occurs during melanoma development. Mice harboring an IFNAR1 mutant, which is partially resistant to downregulation, delay melanoma development, suppress metastatic disease, and better respond to BRAF or PD-1 inhibitors. These result...



Autotaxin, Pruritus and Primary Biliary Cholangitis (PBC)

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: Available online 24 March 2016 Source:Autoimmunity Reviews Author(s): Ying Sun, Weici Zhang, Jilly F. Evans, Annarosa Floreani, Zhengsheng Zou, Yukiko Nishio, Ruizhao Qi, Patrick S.C. Leung, Christopher L. Bowlus, M. Eric Gershwin Autotaxin (ATX) is a 125-kD type II ectonucleotide pyrophosphatase/phosphodiesterase (ENPP2 or NPP2) originally discovered as an unknown “autocrine motility factor” in human melanoma cells. In addition to its pyrophosphatase/phosphodiesterase activities ATX has lysophospholipase D (lysoPLD) activity, catalyzing the conversion of lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). ATX is the only ENPP family member with lysoPLD activity and it produces most of the LPA in circulation. In support of this, ATX heterozygou...

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Excision margins and sentinel lymph node status as prognostic factors in thick melanoma of the head and neck: A retrospective analysis

Thu, 24 Mar 2016 23:00:00 +0100

ConclusionWider margins do not significantly improve locoregional recurrence or MSS. Sentinel lymph node involvement reflects a poor prognosis. © 2016 Wiley Periodicals, Inc. Head Neck, 2016 (Source: Head and Neck)



Status of the Regional Nodal Basin Remains Highly Prognostic in Melanoma Patients with In-Transit Disease

Thu, 24 Mar 2016 23:00:00 +0100

The objective of this study was to determine the rate and prognostic significance of occult nodal disease in patients undergoing surgical nodal staging for IT disease. (Source: Journal of the American College of Surgeons)



Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell.

Thu, 24 Mar 2016 23:00:00 +0100

Authors: Morais KL, Pacheco MT, Berra CM, Bosch RV, Sciani JM, Chammas R, de Freitas Saito R, Iqbal A, Chudzinski-Tavassi AM Abstract During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this context, Amblyomin-X is a Kunitz-type FXa inhibitor similar to endogenous tissue factor pathway inhibitor (TFPI) and is a novel proteasome inhibitor. Herein, we have demonstrated Amblyomin-X cytotoxicity to different tumor cells lines such as pancreatic (Panc1, AsPC1BxPC3) and melanoma (SK-MEL-5 and SK-MEL-28). Of note, Amblyomin-X was not cytotoxic to normal human fibroblast cells. In addition, Amblyomin-X promoted accumulation of ER stress markers (GRP78 and GADD153) in sensitive (SK-MEL-28) and b...



Microneedle patch delivers localized cancer immunotherapy to melanoma

Thu, 24 Mar 2016 18:32:32 +0100

Biomedical engineering researchers have developed a technique that uses a patch embedded with microneedles to deliver cancer immunotherapy treatment directly to the site of melanoma skin cancer. In animal studies, the technique more effectively targeted melanoma than other immunotherapy treatments. (Source: ScienceDaily Headlines)



Sex differences in the incidence of skin and skin‐related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide

Thu, 24 Mar 2016 15:22:23 +0100

Abstract Many skin and skin‐related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin‐related diseases affecting males vs. females, we reviewed published population‐based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers. Males had a higher incidence of ...

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The prognostic significance of indoleamine-2,3-dioxygenase and the receptors for transforming growth factor β and interferon γ in metastatic lymph nodes in malignant melanoma.

Thu, 24 Mar 2016 12:58:02 +0100

Authors: Pelak MJ, Śnietura M, Lange D, Nikiel B, Pecka KM Abstract We analyzed the prognostic significance of indoleamine-2,3-dioxygenase (IDO) and type 1 receptors for transforming growth factor beta (TGF-βR1) and interferon gamma (IFN-γR1) in resected nodal metastases of 48 malignant melanoma patients. In 32 cases the corresponding skin tumors were available. We used immunohistochemical (IHC) staining which was assessed by pathologists and by a computer-aided algorithm that yielded quantitative results, both absolute and relative. We correlated the results with the patient outcome. We identified absolute computer-assessed IDO levels as positively correlated with increased risk of death in a multivariate model (HR = 1.02; 95% CI: 1.002-1.04; p = 0.03). In univariate analysis, ...



Online skin cancer risk assessment tool can predict non-melanoma skin cancer

Thu, 24 Mar 2016 12:05:12 +0100

A new online tool allows people to assess their risks of developing skin cancer in the next three years. Aimed at people over 40, the tool determines the risk level in only a few questions. (Source: the Mail online | Health)



Microneedle patch delivers localized cancer immunotherapy to melanoma

Thu, 24 Mar 2016 04:00:00 +0100

(North Carolina State University) Biomedical engineering researchers have developed a technique that uses a patch embedded with microneedles to deliver cancer immunotherapy treatment directly to the site of melanoma skin cancer. In animal studies, the technique more effectively targeted melanoma than other immunotherapy treatments. (Source: EurekAlert! - Medicine and Health)



Discussion

Thu, 24 Mar 2016 01:35:37 +0100

DR KEITH DELMAN (Atlanta, GA): This is a very transformative time to take care of patients with melanoma. We have seen a dramatic change in the therapies available to us, and our armamentarium and approach to these patients are dramatically different. (Source: Journal of the American College of Surgeons)



BRAF mutations in conjunctival melanoma: investigation of incidence, clinicopathological features, prognosis and paired premalignant lesions

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionThe incidence of conjunctival melanoma increased in Denmark over 50 years. The proportion of BRAF‐mutated conjunctival melanoma was constant. BRAF mutations were identified as early events in conjunctival melanoma, associated with a distinct clinicopathological profile, similar to BRAF‐mutated cutaneous melanoma. Immunohistochemical detection of BRAF can be used to assess BRAF V600E mutations. (Source: Acta Ophthalmologica)



Choroidal melanoma and pregnancy

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionsSurvival in women of childbearing age does not appear to be influenced by pregnancy. We show that proton beam therapy can be used to treat women who are pregnant at the time of choroidal melanoma diagnosis. (Source: Acta Ophthalmologica)



Enhanced local and systemic anti-melanoma CD8+ T cell responses after memory T cell-based adoptive immunotherapy in mice

Wed, 23 Mar 2016 23:00:00 +0100

Abstract Adoptive cell transfer (ACT) melanoma immunotherapy typically employs acutely activated effector CD8+ T cells for their ability to rapidly recognize and clear antigen. We have previously observed that effector CD8+ T cells are highly susceptible to melanoma-induced suppression, whereas memory CD8+ T cells are not. Although memory T cells have been presumed to be potentially advantageous for ACT, the kinetics of local and systemic T cell responses after effector and memory ACT have not been compared. B16F10 melanoma cells stably transfected to express very low levels of the lymphocytic choriomeningitis virus (LCMV) peptide GP33 (B16GP33) were inoculated into syngeneic C57BL/6 mice. Equal numbers of bona fide naïve, effector, or memory phenotype GP33-specific CD8+ T ce...



Dermoscopy in the era of dermato-oncology: from bed to bench side and retour.

Wed, 23 Mar 2016 19:50:02 +0100

Authors: Woltsche N, Schwab C, Deinlein T, Hofmann-Wellenhof R, Zalaudek I Abstract Today dermoscopy is standard-of-care in the diagnosis and management of patients with benign and malignant skin tumors because it increases the diagnostic accuracy of skin lesions compared to the naked-eye examination up to 25%. Despite its role in the routine dermato-oncology, it increasingly gained interest as a bridge connecting clinical with basic molecular research in dermato-oncology. Here, we correlate dermoscopy patterns of nevi and melanomas with high and low susceptibility genes and somatic mutations, provide an overview on the clinical and dermoscopic patterns of cutaneous melanoma subtypes, and highlight the role of dermoscopy in the diagnosis of skin eruptions during systemic treatments...



Breakthrough in diagnosis of melanoma skin cancer

Wed, 23 Mar 2016 19:18:48 +0100

Researchers have revealed a remarkable link between malignant melanoma and a non-coding RNA gene called SAMMSON. The SAMMSON gene is expressed in human malignant melanoma and, strikingly, the growth of aggressive skin cancer is highly dependent on this gene. The conclusions could pave the way for improved diagnostic tools and skin cancer treatment. (Source: ScienceDaily Headlines)

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Cobimetinib and vemurafenib for the treatment of Melanoma.

Wed, 23 Mar 2016 16:52:02 +0100

Authors: Boespflug A, Thomas L Abstract INTRODUCTION: Cobimetinib combined with vemurafenib is a new approved MEK inhibitor for first line treatment of metastatic melanoma patients with BRAF V600 mutations. It improves tumor response rates and progression free survival compared to vemurafenib alone, while decreasing toxicities due to the paradoxical activation of the MAPK signaling pathway. Areas covered: This review covers the pharmacology, efficacy, and toxicity data derived from clinical and preclinical studies on cobimetinib. It also reports ongoing trials evaluating cobimetinib to better understand future developments for this drug. Expert opinion: The combination of cobimetinib and vemurafenib seems to be more toxic than the combination therapy dabrafenib and trametinib even ...



Melanocytic Nevus on the Rectal Mucosa Removed Using Endoscopic Submucosal Dissection.

Wed, 23 Mar 2016 12:41:08 +0100

Authors: Kim SM, Shin YJ, Sim JS, Lee BJ, Joo MK, Park JJ, Bak YT Abstract Melanocytic nevus is the benign proliferation of melanocytes. The most common location of melanocytic nevus is the skin of the extremities; however, there are few case reports of melanocytic nevus at the rectal mucosa. No prior case of malignant melanoma from melanocytic nevus at the rectal mucosa has been reported; therefore, it is unclear whether resection should be performed or close observation is sufficient. However, the potential malignant transformation of melanocytic nevus should be considered, including melanocytic nevus on the rectum. Melanocytic nevus of the skin can be removed by surgical excision; however, due to rare incidence on the mucosa of the gastrointestinal tract, the optimal treatment f...



Acantholytic-Like Pattern in a Recurrent Melanoma Mimicking Acantholytic Squamous Cell Carcinoma: A Further Example Highlighting the Potential for Misdiagnosis

Wed, 23 Mar 2016 04:43:42 +0100

No abstract available (Source: The American Journal of Dermatopathology)



Fluorescence In Situ Hybridization for Melanoma Diagnosis: A Review and a Reappraisal

Wed, 23 Mar 2016 04:43:41 +0100

Abstract: Although conventional histopathological examination is the undisputable mainstay for the diagnosis of melanocytic skin neoplasms, fluorescence in situ hybridization (FISH) has the potential to provide important information to morphologically challenging cases. The standard melanoma FISH test targeting RREB1 (6p25), MYB (6q23), CCND1 (11q13), and centromere 6 is an effective compromise between cost, technical complexity, and sensitivity. The authors use the standard FISH-positivity as a tie-breaker for challenging melanocytic neoplasms mainly in a non-Spitzoid morphologic context because the currently available test leaves several unresolved issues: namely, a relatively low diagnostic accuracy in morphologically ambiguous melanocytic neoplasms; a relatively low sensitivity and spe...



Clinical Follow-up of Atypical Spitzoid Tumors Analyzed by Fluorescence In Situ Hybridization

Wed, 23 Mar 2016 04:43:41 +0100

In this study, we examined 36 ASTs analyzed by FISH for specific abnormalities in chromosomes 6, 9, and 11. Aberrations were detected in 11 cases, 7 of which met FISH criteria for spitzoid melanoma. These had homozygous deletion of 9p21, partial deletion of 11q13, gain of 6p25, and gain of 11q13. All 3 patients with positive sentinel lymph nodes, including one with progression beyond the sentinel lymph node, had homozygous deletion of chromosome 9p21, but there were no deaths in an average of 28 months of follow-up of these cases. Other aberrations in the chromosomal pattern of ASTs were heterozygous deletion of 9p21, partial deletion of 6p23, and tetraploidy. We found that ASTs, including those eventually diagnosed as spitzoid melanoma, had a more indolent course in our cohort than conven...

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Bilateral isolated choroidal melanocytosis

Wed, 23 Mar 2016 04:26:49 +0100

Conclusion: Although extremely rare, bilateral isolated choroidal melanocytosis may occur in young patients, as well as in those who are African American. Longer follow-up of this case and those in the literature will elucidate whether these choroidal lesions enlarge or have a risk of developing uveal melanoma. (Source: Retinal Cases and Brief Reports)



Pseudo uveal melanoma caused by optic disk drusen with juxtapapillary choroidal neovascular membrane

Wed, 23 Mar 2016 04:26:49 +0100

Conclusion: In the setting of diagnostic uncertainty, careful multimodal imaging can assist in distinguishing between malignant choroidal melanoma and a benign simulating lesion. Optic disk drusen with associated neovascularization and hemorrhage should be included in the list of pseudomelanomas. (Source: Retinal Cases and Brief Reports)



Choroidal melanoma initially treated as hemangioma: diagnostic and therapeutic considerations

Wed, 23 Mar 2016 04:26:49 +0100

Conclusion: Differentiating between amelanotic melanoma and choroidal hemangioma can be challenging. Relying solely on ophthalmoscopic features can be misleading. Ancillary studies such as indocyanine green and standardized A-scan ultrasonography bring clarity in differentiating circumscribed choroidal hemangioma from choroidal melanoma. Although cytology or histopathology is the only definitive method of establishing the diagnosis, careful emphasis on key diagnostic features can obviate the need for diagnostic fine-needle aspiration biopsy in most cases. (Source: Retinal Cases and Brief Reports)



VIB, KU Leuven and UGent achieve breakthrough in diagnosis of melanoma skin cancer

Wed, 23 Mar 2016 04:00:00 +0100

(VIB (the Flanders Institute for Biotechnology)) In collaboration with researchers from UGent, VIB scientists from KU Leuven have revealed a remarkable link between malignant melanoma and a non-coding RNA gene called SAMMSON. The SAMMSON gene is expressed in human malignant melanoma and, strikingly, the growth of aggressive skin cancer is highly dependent on this gene. The conclusions could pave the way for improved diagnostic tools and skin cancer treatment. (Source: EurekAlert! - Cancer)



Yttrium-90 Microsphere Brachytherapy for Liver Metastases From Uveal Melanoma: Clinical Outcomes and the Predictive Value of Fluorodeoxyglucose Positron Emission Tomography

Wed, 23 Mar 2016 00:15:31 +0100

Objectives: To report outcomes after yttrium-90 microsphere brachytherapy for unresectable liver metastases from uveal melanoma and to evaluate factors predictive for overall survival (OS) and hepatic progression-free survival (PFS). Methods: A total of 71 patients were consecutively treated with microsphere brachytherapy for unresectable liver metastases from uveal melanoma between 2007 and 2012. Clinical, radiographic, and positron emission tomography–derived, functional tumor parameters were evaluated by log-rank test in univariate analysis and backwards stepwise multivariate Cox proportional hazards regression. OS and hepatic PFS were estimated by Kaplan-Meier analysis. Results: A total of 134 procedures were performed in 71 patients with a median age of 63 years (range, 23 to 91 y...

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Polarization of M1 tumor associated macrophage promoted by the activation of TLR3 signal pathway

Tue, 22 Mar 2016 23:00:00 +0100

Conclusions The Poly-ICLC can activate the TLR3 downstream signaling pathway to induce a M1 polarization of tumor associated macrophage, thereby inhibiting the tumor growth. (Source: Asian Pacific Journal of Tropical Medicine)



Antigen‐specific TIL therapy for melanoma: A flexible platform for personalized cancer immunotherapy

Tue, 22 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved (Source: European Journal of Immunology)



Prognostic factors and disease‐specific survival among immigrants diagnosed with cutaneous malignant melanoma in Sweden

Tue, 22 Mar 2016 23:00:00 +0100

In conclusion, the CMM‐specific survival was significantly decreased among women from former Yugoslavia compared to Swedish‐born women (hazard ratio (HR) = 2.2; 95% CI=1.1 ‐ 4.2; P=0.043). After additional adjustment including stage, the survival difference was no longer significant. No survival difference between the second generation immigrant group and Swedish‐born patients were observed. A worse CMM‐specific survival in women from former Yugoslavia was associated with more advanced stages of CMM at diagnosis. Secondary prevention efforts focusing on specific groups may be needed to further improve CMM prognosis. This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



Melanoma addiction to the long non-coding RNA SAMMSON

Tue, 22 Mar 2016 23:00:00 +0100

Authors: Eleonora Leucci, Roberto Vendramin, Marco Spinazzi, Patrick Laurette, Mark Fiers, Jasper Wouters, Enrico Radaelli, Sven Eyckerman, Carina Leonelli, Katrien Vanderheyden, Aljosja Rogiers, Els Hermans, Pieter Baatsen, Stein Aerts, Frederic Amant, Stefan Van Aelst, Joost van den Oord, Bart de Strooper, Irwin Davidson, Denis L. J. Lafontaine, Kris Gevaert, Jo Vandesompele, Pieter Mestdagh & Jean-Christophe Marine Focal amplifications of chromosome 3p13–3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the epicentre of this amplicon. However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA (lncRNA)...



Final Results of the Sunbelt Melanoma Trial: A Multi-Institutional Prospective Randomized Phase III Study Evaluating the Role of Adjuvant High-Dose Interferon Alfa-2b and Completion Lymph Node Dissection for Patients Staged by Sentinel Lymph Node Biopsy [Melanoma]

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion No survival benefit for adjuvant HDI in patients with a single positive SLN was found. Among patients with tumor-negative SLN by conventional pathology but with melanoma detected in the SLN by RT-PCR, there was no OS benefit for CLND or CLND+HDI. (Source: Journal of Clinical Oncology)

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CUSTOM-SEQ: A Prototype for Oncology Rapid Learning in a Comprehensive EHR Environment

Tue, 22 Mar 2016 23:00:00 +0100

Background: As targeted cancer therapies and molecular profiling become widespread, the era of "precision oncology" is at hand. However, cancer genomes are complex, making mutation-specific outcomes difficult to track. We created a proof-of-principle, CUSTOM-SEQ: Continuously Updating System for Tracking Outcome by Mutation, to Support Evidence-based Querying, to automatically calculate and display mutation-specific survival statistics from electronic health record data.Methods: Patients with cancer genotyping were included, and clinical data was extracted through a variety of algorithms. Results were refreshed regularly and injected into a standard reporting platform. Significant results were highlighted for visual cueing. A subset was additionally stratified by stage, smoking status, and...



Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study

Tue, 22 Mar 2016 23:00:00 +0100

The prognosis of melanoma patients who are diagnosed with multiple primary lesions remains controversial. We used a large, population-based cohort to re-examine this issue, applying a delayed entry methodology to avoid survival bias. Of 32,238 eligible patients diagnosed between 1995 and 2008, 29,908 (93%) had a single invasive melanoma, 2,075 (6%) had two and 255 (1%) had three. Allowing for differences in entry time, 10-year cause-specific survival for these three groups was 89% (95% CI = 88%-90%), 83% (95% CI = 80%-86%) and 67% (95% CI = 54%-81%), respectively. (Source: Journal of Investigative Dermatology)



Antigen-specific TIL therapy for melanoma: A flexible platform for personalized cancer immunotherapy.

Tue, 22 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. PMID: 27005018 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)



A Unifying Concept of Uveal Pigment Cell Distribution and Dissemination Based on an Animal Model: Insights into Ocular Melanogenesis

Tue, 22 Mar 2016 21:43:14 +0100

Pigmented cells are derived from neural crest cells, which migrate along the peripheral nerve sheets into their specific final region. During their migration, cells progressively acquire pigment-producing capabilities, maturation, and the shape of melanocytes. These insights, along with specific clinical characteristics of melanocytic nevi, have led to new concepts of cutaneous, periocular, and iris nevogenesis. To further elucidate the specific ocular embryogenic melanoblast distribution and dissemination - that could explain the distinct distribution of uveal melanocytic neoplasms - we investigated the ocular pigmentation of dogs affected by a specific mutation called Merle, which results in either pigment- (wild type) or non-pigment- (mutated type) producing cells. Based on our observat...



Optical Coherence Tomography: An Adjunctive Tool for Differentiating between Choroidal Melanoma and Metastasis.

Tue, 22 Mar 2016 19:22:02 +0100

Conclusion. OCT may serve as a noninvasive adjunctive tool for the differential diagnosis of choroidal tumors. Choroidal melanomas usually demonstrate regular surfaces on OCT, while choroidal metastases usually have an irregular and lobulated surface. PMID: 26998354 [PubMed] (Source: Journal of Ophthalmology)

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Erratum: Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures.

Tue, 22 Mar 2016 17:43:02 +0100

Authors: Curiel-Olmo S, García-Castaño A, Vidal R, Pisonero H, Varela I, León-Castillo A, Trillo E, González-Vela C, García-Diaz N, Almaraz C, Moreno T, Cereceda L, Madureira R, Martinez N, Ortiz-Romero P, Valdizán E, Piris MA, Vaqué JP Abstract See original article: Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures. PMID: 26997263 [PubMed - as supplied by publisher] (Source: Oncotarget)



l-Rhamnose Enhances the Immunogenicity of Melanoma-Associated Antigen A3 for Stimulating Antitumor Immune Responses

Tue, 22 Mar 2016 13:29:19 +0100

Bioconjugate ChemistryDOI: 10.1021/acs.bioconjchem.6b00081 (Source: Bioconjugate Chemistry)



The Microphthalmia-Associated Transcription Factor p.E318K Mutation Does Not Play a Major Role in Sporadic Renal Cell Tumors from Caucasian Patients

Tue, 22 Mar 2016 10:07:21 +0100

Conclusion: The MITF p.E318K mutation does not appear to play a major role in sporadic RCC carcinogenesis, but is possibly restricted to a rare subpopulation of inherited RCC.Pathobiology 2016;83:113-117 (Source: Pathobiology)



Identifying relevant group of miRNAs in cancer using fuzzy mutual information

Tue, 22 Mar 2016 03:07:01 +0100

Abstract MicroRNAs (miRNAs) act as a major biomarker of cancer. All miRNAs in human body are not equally important for cancer identification. We propose a methodology, called FMIMS, which automatically selects the most relevant miRNAs for a particular type of cancer. In FMIMS, miRNAs are initially grouped by using a SVM-based algorithm; then the group with highest relevance is determined and the miRNAs in that group are finally ranked for selection according to their redundancy. Fuzzy mutual information is used in computing the relevance of a group and the redundancy of miRNAs within it. Superiority of the most relevant group to all others, in deciding normal or cancer, is demonstrated on breast, renal, colorectal, lung, melanoma and prostate data. The merit of FMIMS as compared ...



Editorial: Combination Strategies in the Treatment of Melanoma

Tue, 22 Mar 2016 00:00:00 +0100

Paolo Antonio Ascierto (Source: Frontiers in Oncology)

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Amazing Allison: A Young ‘Pioneer’ And The Boston Doctors Who Saved Her

Mon, 21 Mar 2016 23:46:30 +0100

BOSTON (CBS) – Just before Allison Schablein’s fifth birthday, she was diagnosed with brain cancer. Seven metastatic, malignant gliomas. Doctors could only remove one of them. Allison received chemotherapy. But it didn’t stop the cancer from growing. “She started with a terrible tumor in the worst circumstance,” says Dr. Mark Kieran, Director of Pediatric Neuro-Oncology at Dana Farber Cancer Institute. Fortunately, new technology allowed Dr. Kieran and the doctors at both Dana Farber and Boston Children’s Hospital to do a molecular profile of the single tumor they had removed. Incredibly, they discovered that Allison’s cancer had a mutation also found in some skin cancer patients—specifically adults with melanoma. And for those adult patients, there was actually a highl...



Importance and methods of searching for E-publications ahead of print in systematic reviews

Mon, 21 Mar 2016 23:00:00 +0100

In an attempt to keep pace with the increasing number of trials being conducted each year, journals make articles available as E-publications ahead of print. E-publications are not available to search through the conventional databases (MEDLINE, EMBASE, CENTRAL) used in systematic reviews, but are searchable using PubMed. We used a search syntax designed to exclusively identify E-publications in PubMed to assess the importance of searching for E-publications in systematic reviews. Two case studies were conducted: updating de novo systematic reviews in particularly active areas of current research, type 2 diabetes mellitus and advanced melanoma. A search for E-publications was conducted concurrently to the conventional systematic reviews. Network diagrams were constructed with and without t...



Healthy Skin: Cancer Education for School Teachers and Nurses Using a “Train and Equip” Method

Mon, 21 Mar 2016 23:00:00 +0100

Abstract Skin cancer, especially malignant melanoma, continues on the increase. Different interventions are attempting to impact on this problem. The approach used by the Partners in Health Sciences program at the University of Arkansas for Medical Science is to both “train” and, importantly, “equip” classroom teachers and school nurses in a “Healthy Skin” professional development curriculum. Each participant not only received face-to-face interactive content training in a workshop setting that lasted 6 h; each also received a resource kit of supplies, materials, and equipment used in the workshop and designed for the trainee to use with students in a classroom/school setting. This single “hit” professional development event then can be replicated by each trainee ...



Skin Cancer Incidence and Mortality in Spain: A Systematic Review and Meta-Analysis

Mon, 21 Mar 2016 23:00:00 +0100

Conclusions The registration methodology normally used by cancer registries probably underestimates the incidence rates of basal cell and squamous cell carcinoma in Spain. The incidence rates of cutaneous melanoma and Merkel cell carcinoma are lower in Spain than in other European countries. (Source: Actas Dermo-Sifiliograficas)



Phase 1 study of pembrolizumab (MK-3475; anti-PD-1 monoclonal antibody) in Japanese patients with advanced solid tumors

Mon, 21 Mar 2016 23:00:00 +0100

Conclusions Pembrolizumab at both 2 and 10 mg/kg Q2W was well tolerated in Japanese patients with advanced solid tumors and showed encouraging anti-tumor activity against melanoma and NSCLC. (Source: Investigational New Drugs)

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Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Mon, 21 Mar 2016 23:00:00 +0100

Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma and conjunctival melanoma, which are very rare in Black people. The symptoms are not tumour‐specific and are related to the organ system affected, and the disease is most often diagnosed at an advanced cli...



LINE-1 hypomethylation and mutational status in cutaneous melanomas

Mon, 21 Mar 2016 23:00:00 +0100

Epigenetic dysregulation is an important emerging hallmark of cutaneous melanoma development. The global loss of DNA methylation in gene-poor regions and transposable DNA elements of cancer cells contributes to increased genomic instability. Long interspersed element-1 (LINE-1) sequences are the most abundant repetitive sequence of the genome and can be evaluated as a surrogate marker of the global level of DNA methylation. In this work, LINE-1 methylation levels were evaluated in cutaneous melanomas and normal melanocyte primary cell cultures to investigate their possible association with both distinct clinicopathological characteristics and tumor mutational profile. A set of driver mutations frequently identified in cutaneous melanoma was assessed by sequencing (actionable mutations in B...



Id: 93: structure-activity relationships of synthesized quercetin derivatives on anti-proliferation and anti-migration activity in b16 melanoma cells

Mon, 21 Mar 2016 23:00:00 +0100

Conclusion These data indicate that the methoxyl group at C-3 position plays an important role to inhibit migration in B16 melanoma cells. Among the quercetin derivatives showing potent anti-migration activity, 34'7TMQ inhibited migration at most which suggests that the methoxyl groups at C-4' and 7 would accelerate the activity. The data on cell proliferation and cytotoxicity exhibit that 37DMQ and 34'DMQ inhibit proliferation of the cancer cells without cytotoxicity to the cells. (Source: Journal of Investigative Medicine)



Id: 95: il-33/st2 triggering of il-9-secreting t cells: from proteomics to therapeutics

Mon, 21 Mar 2016 23:00:00 +0100

As one of the most validated immunotherapies to date, allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative option for high-risk hematological malignancies, particularly acute myeloid leukemia (AML). The immunotherapeutic activity of allo-HCT is known as the graft-vs-leukemia (GVL) activity. However, GVL activity is often accompanied by T-cell reactivity to allo-antigens in normal host tissues, which leads to graft-versus-host disease (GVHD), another major cause of death after HCT. Therefore, there is a great unmet need to improve the current process of allo-HCT through increasing the GVL activity and decreasing GVHD. We have shown that an elevated plasma level of soluble (s)ST2 in HCT patients is a risk factor for severe GVHD. ST2 blockade reduces sST2-produci...



Examining the Differences in Current Regulatory Processes for Sunscreens and Proposed Safety Assessment Paradigm

Mon, 21 Mar 2016 23:00:00 +0100

Publication date: Available online 22 March 2016 Source:Regulatory Toxicology and Pharmacology Author(s): Edward V. Sargent, Jeffrey B. Travers Skin cancers including malignant melanoma which are due to UV radiation constitute a serious public health problem. Recent studies have confirmed the importance of UVA radiation in the pathogenesis of skin cancer, as well as the protective effects of broad-spectrum sunscreen use. Barriers for effective protection of the US public include the lack of effective UV filters, especially in the UVA spectrum. The major reason for the paucity of UVA-effective filters in the US is due primarily to the FDA's reluctance to approve agents which have already been on the market in Europe and elsewhere in the world for more than a decade. The underlying reaso...

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MiR-508-5p Inhibits the Progression of Glioma by Targeting Glycoprotein Non-metastatic Melanoma B.

Mon, 21 Mar 2016 23:00:00 +0100

In conclusion, these results indicate that increased expression of miR-508-5p might be related to glioma progression, indicating a potential role of miR-508-5p for clinical therapy. PMID: 27003587 [PubMed - as supplied by publisher] (Source: Neurochemical Research)



Long-lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with tumor-infiltrating lymphocytes and an attenuated IL-2 regimen.

Mon, 21 Mar 2016 23:00:00 +0100

CONCLUSIONS: TIL-ACT with a reduced IL-2 decrescendo regimen results in long-lasting complete responses in patients with treatment-refractory melanoma. Larger randomized trials are needed to elucidate whether clinical efficacy is comparable to TIL-ACT followed by HD bolus IL-2. PMID: 27006492 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)



A novel integrative approach to identify lncRNAs associated with the survival of melanoma patients.

Mon, 21 Mar 2016 23:00:00 +0100

In this study, we developed a novel simple computational approach, which didn't use lncRNA expression, to identify lncRNAs associated with the survival of melanoma patients through integrating gene expression and lncRNA-target networks. First, we calculated the significance of associations between gene expression and patients' survival. Second, we constructed the experimentally validated lncRNA-target gene networks. Next, the significance of lncRNAs were obtained by combination of the p-values of their neighbor genes. Finally, we identified 15 lncRNAs that were significantly associated with the survival of melanoma patients (p<0.05), which were supported by functional analysis and literature review. Collectively, this study provides an effective approach to predict the lncRNA signatures...



Examining the Differences in Current Regulatory Processes for Sunscreens and Proposed Safety Assessment Paradigm.

Mon, 21 Mar 2016 23:00:00 +0100

Authors: Sargent EV, Travers JB Abstract Skin cancers including malignant melanoma which are due to UV radiation constitute a serious public health problem. Recent studies have confirmed the importance of UVA radiation in the pathogenesis of skin cancer, as well as the protective effects of broad-spectrum sunscreen use. Barriers for effective protection of the US public include the lack of effective UV filters, especially in the UVA spectrum. The major reason for the paucity of UVA-effective filters in the US is due primarily to the FDA's reluctance to approve agents which have already been on the market in Europe and elsewhere in the world for more than a decade. The underlying reasons for these discrepancies in new sunscreen approval success between the US and abroad are complex,...



Why We Should All Celebrate World Down Syndrome Day

Mon, 21 Mar 2016 20:47:45 +0100

March 21st is internationally recognized as World Down Syndrome Day. Just like typical people, individuals with Down syndrome have two copies of each of their 23 chromosomes but they have third copy of chromosome 21, a genetic condition known as trisomy 21, hence the celebration on March 21st or 3-21. While it is important to celebrate all the things that people with Down syndrome can do and how similar they are to others, I would argue it is equally important to acknowledge the ongoing fight against discrimination that their differences evoke. If we consider that discrimination leveled against women or African Americans in our country is based on whether someone is born with an X or Y chromosome or with a few gene variants that define skin pigmentation, it is easy to see how people with ...

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Low vitamin D linked with worse outcome in melanoma

Mon, 21 Mar 2016 20:00:00 +0100

Lower levels of vitamin D in patients with melanoma were associated with poorer survival, independent of effects from systemic inflammation indicated by simultaneous C-reactive protein (CRP) measures, according to researchers. Multivariate analysis showed that vitamin D level was associated with... (Source: Skin and Allergy News)



Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.

Mon, 21 Mar 2016 05:47:03 +0100

Authors: Sung H, Kanchi KL, Wang X, Hill KS, Messina JL, Lee JH, Kim Y, Dees ND, Ding L, Teer JK, Yang S, Sarnaik AA, Sondak VK, Mulé JJ, Wilson RK, Weber JS, Kim M Abstract Inactivation of Ras GTPase activating proteins (RasGAPs) can activate Ras, increasing the risk for tumor development. Utilizing a melanoma whole genome sequencing (WGS) data from 13 patients, we identified two novel, clustered somatic missense mutations (Y472H and L481F) in RASA1 (RAS p21 protein activator 1, also called p120RasGAP). We have shown that wild type RASA1, but not identified mutants, suppresses soft agar colony formation and tumor growth of BRAF mutated melanoma cell lines via its RasGAP activity toward R-Ras (related RAS viral (r-ras) oncogene homolog) isoform. Moreover, R-Ras increased and RASA1...



Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Rα overexpressed melanoma models.

Mon, 21 Mar 2016 05:47:03 +0100

Authors: Lee HL, Park MH, Song JK, Jung YY, Kim Y, Kim KB, Hwang DY, Yoon DY, Song MJ, Han SB, Hong JT Abstract To evaluate the significance of interleukin 4 (IL-4) in tumor development, we compared B16F10 melanoma growth in IL-4-overespressing transgenic mice (IL-4 mice) and non-transgenic mice. In IL-4 mice, reduced tumor volume and weight were observed when compared with those of non-transgenic mice. Significant activation of DNA binding activity of STAT6, phosphorylation of STAT6 as well as IL-4, IL-4Rα and p21 expression were found in the tumor tissues of IL-4 mice compared to non-transgenic mice. Higher expression of IL-4, STAT6 and p21 in human melanoma tissue compared to normal human skin tissue was also found. Higher expression of apoptotic protein such as cleaved caspase...



Herpes Virus Fights Cancer?

Mon, 21 Mar 2016 05:00:00 +0100

SALT LAKE CITY. (Ivanhoe Newswire) -- The FDA says about 74,000 Americans were diagnosed with melanoma, a type of skin cancer. Last year, nearly 10,000 of them died of it. Now, researchers have a new weapon in their arsenal; one that comes from a genetically-altered herpes virus. Here’s more about the first cancer-killing viral therapy ever approved in the U.S. (Source: Medical Headlines From Ivanhoe.com)



Registered Report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Mon, 21 Mar 2016 00:00:00 +0100

(Source: eLife)

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Enhancing the evaluation of PI3K inhibitors through 3D melanoma models

Mon, 21 Mar 2016 00:00:00 +0100

Summary Targeted therapies for mutant BRAF metastatic melanoma are effective but not curative due to acquisition of resistance. PI3K signaling is a common mediator of therapy resistance in melanoma; thus, the need for effective PI3K inhibitors is critical. However, testing PI3K inhibitors in adherent cultures is not always reflective of their potential in vivo. To emphasize this, we compared PI3K inhibitors of different specificity in two‐ and three‐dimensional (2D, 3D) melanoma models and show that drug response predictions gain from evaluation using 3D models. Our results in 3D demonstrate the anti‐invasive potential of PI3K inhibitors and that drugs such as PX‐866 have beneficial activity in physiological models alone and when combined with BRAF inhibition. These assays finally...



Reinforcing B16F10/GPI-IL-21 vaccine efficacy against melanoma by injecting mice with shZEB1 plasmid or miR200c agomir

Mon, 21 Mar 2016 00:00:00 +0100

In this study, we hypothesized that the inhibition of epithelial to mesenchymal transition (EMT) program by knockdown of Zinc-finger E-box binding homeobox 1 (ZEB1) or administration of miR200c agomir would strengthen the B16F10 cells transfected with GPI-anchored IL-21 (B16F10/GPI-IL-21) vaccine efficacy in inhibiting the melanoma metastasis. Our findings from the current study indicated that, when compared with the mice immunized with the B16F10/GPI-IL-21 vaccine alone, the mice immunized with B16F10/GPI-IL-21 vaccine combined with injection of shZEB1 plasmid or miR200c agomir not only meaningfully inhibited EMT of melanoma, reduced the EMT characteristic molecular expression in tumor tissues, but also significantly decreased the Treg cells and TGF-β1, enhanced the cytotoxicities of NK ...



MITF: More Interesting Traits, Folks!

Sun, 20 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. PMID: 26999069 [PubMed - as supplied by publisher] (Source: Pigment Cell and Melanoma Research)



Update on Metastatic Uveal Melanoma: Progress and Challenges

Sun, 20 Mar 2016 23:00:00 +0100

Abstract Uveal melanoma is a rare and biologically distinct type of melanoma arising from melanocytes of the uveal tract; it is associated with a poor prognosis due to the lack of effective systemic treatments. Recent advances in the pathogenesis of uveal melanoma offer an unprecedented opportunity for investigation of new compounds. The purpose of this paper was to analyse the existing evidence about the molecular pathology and immunobiology of advanced uveal melanoma and their implications for systemic targeted therapies and immunotherapy, as well as to discuss future treatment strategies based on data provided by clinical and translational research studies. (Source: BioDrugs)



Primary advanced esophago-gastric melanoma: A rare case.

Sun, 20 Mar 2016 23:00:00 +0100

Authors: Wang L, Zong L, Nakazato H, Wang WY, Li CF, Shi YF, Zhang GC, Tang T Abstract Primary esophageal or gastric melanoma is a very rare disease with early metastasis. Due to its atypical symptom and less efficiency of chemotherapy and radiotherapy, the prognosis of esophageal or gastric melanoma is still very poor. Surgical resection remains the preferential treatment for esophageal or gastric melanoma. Here we present an extremely rare case of primary advanced esophago-gastric melanoma. Debulking surgery was performed without chemotherapy or radiotherapy. However, abdominal recurrence and hepatic metastases were found within one month by a postoperative follow-up computed tomography. Three and a half months after surgical resection, the patient died of extensive abdominal met...

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Recognizing melanoma: Diagnosis and treatment options

Sun, 20 Mar 2016 13:20:00 +0100

Abstract: Melanoma is a malignant tumor that is usually cutaneous in origin and is associated with significant morbidity and mortality. As one of the most common cancers seen in young adults, melanoma represents a major public health concern in terms of years of lost productivity. (Source: The Nurse Practitioner)



Rare cause of non-healing foot wound - acral lentiginous melanoma. Case Report.

Sun, 20 Mar 2016 11:58:02 +0100

Authors: Gerslova A, Pokorna A, Stukavcova A, Veverkova L Abstract The etiology of skin integrity disorders of the lower extremities can be very diverse. In addition to common diagnoses such as venous ulcers with ischemic etiology, decubitus ulcers and diabetic foot syndrome, ulceration of a malignant etiology must also be considered. Malignant melanoma is one of the most dangerous forms of skin cancer and, although rare, may cause foot lesions. The most frequently encountered type of melanoma on acral parts of the limbs is the rare acral lentiginous variant, which only occurs in 2-10% of all melanoma types. Clinical manifestation ranges from cutaneous surface erosion to ulceration with surrounding hyperkeratosis, which can cause considerable differential diagnostic difficulties in...



Predictive factors in non-melanoma skin cancers treated with electrochemotherapy.

Sun, 20 Mar 2016 11:07:02 +0100

CONCLUSIONS: According to our results, in electrochemotherapy different individual variables can have an important influence, which shows how this treatment could improve. The refinement of the technique and the optimization of patients' selection has the aim to improve the therapeutic response. PMID: 26989995 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)



C-Kit non-mutated metastatic melanoma showing positive response to Nilotinib.

Sun, 20 Mar 2016 01:46:01 +0100

We report a case of non-kit mutated metastatic vaginal melanoma showing impressive response to nilotinib. PMID: 26990482 [PubMed - in process] (Source: Dermatol Online J)

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A 10-year review of outpatient skin biopsy results and skin cancer subtypes.

Sun, 20 Mar 2016 01:46:01 +0100

Authors: DeMarco SS, Vos P, Green H, Defazio J, Davis N, Fiz L, Phillips C Abstract The results of skin biopsies over a 10 year period were reviewed from the outpatient dermatology clinic at the Brody School of Medicine in Greenville, North Carolina. This research was conducted because there are very few studies that characterize this information over a long-term horizon. The biopsy rate per patient encounter, the clinical reason for the biopsy, the biopsy outcomes, the distribution of cutaneous malignancies per encounter, and the distribution of the subtypes of basal cell carcinoma, squamous cell carcinoma, and melanoma were analyzed. Biopsy logs from January 1, 2001 to December 31, 2010 were reviewed. Our investigation found that 20% of patient encounters resulted in a biopsy. Of...