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Preview: MedWorm: Basal Cell Carcinoma

MedWorm: Basal Cell Carcinoma



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Basal Cell Carcinoma category.



Last Build Date: Tue, 29 Mar 2016 16:50:30 +0100

 



Paraconsistent analysis network applied in the treatment of Raman spectroscopy data to support medical diagnosis of skin cancer

Sun, 27 Mar 2016 22:00:00 +0100

Abstract Paraconsistent logic (PL) is a type of non-classical logic that accepts contradiction as a fundamental concept and has produced valuable results in the analysis of uncertainties. In this work, algorithms based on a type of PL—paraconsistent annotated logic of two values (PAL2v)—are interconnected into a network of paraconsistent analysis (PANnet). PANnet was applied to a dataset comprising 146 Raman spectra of skin tissue biopsy fragments of which 30 spectra were determined to represent normal skin tissue (N), 96 were determined to represent tissue with basal cell carcinoma, and 19 were determined to be tissue with melanoma (MEL). In this database, paraconsistent analysis was able to correctly discriminate 136 out of a total of 145 fragments, obtaining a 93.793 % cor...

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Need for Sun cream with your manicure? - Dangers of UV nail dryers

Sun, 27 Mar 2016 22:00:00 +0100

Over 102,000 cases of non-melanoma skin cancer (NMSC) were reported in 2011 with rates growing annually.1 The main NMSC is basal cell carcinoma accounting for 75%, with others including squamous cell carcinoma. It has been estimated that 90% of NMSC originates from exposure to UV light; which initiates malignant transformation in keratinocytes and reduces the protective inflammatory and immune.2 The increasing incidence has been attributed to an ageing population, rises in recreational activity associated with skin exposure, and use of sunbeds. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)



Sex differences in the incidence of skin and skin‐related diseases in Olmsted County, Minnesota, United States, and a comparison with other rates published worldwide

Thu, 24 Mar 2016 15:22:23 +0100

Abstract Many skin and skin‐related diseases affect the sexes unequally, with attendant implications for public health and resource allocation. To evaluate better the incidence of skin and skin‐related diseases affecting males vs. females, we reviewed published population‐based epidemiology studies of skin disorders performed utilizing Rochester Epidemiology Project data. Females had a higher incidence of the following diseases: connective tissue diseases (scleroderma, morphea, dermatomyositis, primary Sjögren syndrome, systemic lupus erythematosus [not in all studies]), pityriasis rosea, herpes progenitalis, condyloma acuminatum, hidradenitis suppurativa, herpes zoster (except in children), erythromelalgia, venous stasis syndrome, and venous ulcers. Males had a higher incidence of ...



Facial extensive ulcer

Wed, 23 Mar 2016 03:16:17 +0100

We present a clinical case recently reported in our unit.RESUMO Carcinoma basoescamoso, conforme descrito em 1910, é uma variedade distinta de câncer de pele e sua etiologia e características patológicas têm gerado muita controvérsia ao longo dos anos. Atualmente, BSC é considerado um subtipo de carcinoma de células basais com comportamento agressivo e maior tendência para a recorrência e metástase. Nós apresentamos um caso clínico relatado recentemente em nossa unidade. (Source: Revista da Associacao Medica Brasileira)



When should a patient be referred for bariatric surgery?

Wed, 23 Mar 2016 03:16:17 +0100

We present a clinical case recently reported in our unit.RESUMO Carcinoma basoescamoso, conforme descrito em 1910, é uma variedade distinta de câncer de pele e sua etiologia e características patológicas têm gerado muita controvérsia ao longo dos anos. Atualmente, BSC é considerado um subtipo de carcinoma de células basais com comportamento agressivo e maior tendência para a recorrência e metástase. Nós apresentamos um caso clínico relatado recentemente em nossa unidade. (Source: Revista da Associacao Medica Brasileira)



Approach to the history of bioethics in the professional education of podiatry in Spain

Wed, 23 Mar 2016 03:16:17 +0100

We present a clinical case recently reported in our unit.RESUMO Carcinoma basoescamoso, conforme descrito em 1910, é uma variedade distinta de câncer de pele e sua etiologia e características patológicas têm gerado muita controvérsia ao longo dos anos. Atualmente, BSC é considerado um subtipo de carcinoma de células basais com comportamento agressivo e maior tendência para a recorrência e metástase. Nós apresentamos um caso clínico relatado recentemente em nossa unidade. (Source: Revista da Associacao Medica Brasileira)

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"My (critically ill) patient has only a pneumonia" - the risk of oversimplification and the evidence of post-ICU syndrome

Wed, 23 Mar 2016 03:16:17 +0100

We present a clinical case recently reported in our unit.RESUMO Carcinoma basoescamoso, conforme descrito em 1910, é uma variedade distinta de câncer de pele e sua etiologia e características patológicas têm gerado muita controvérsia ao longo dos anos. Atualmente, BSC é considerado um subtipo de carcinoma de células basais com comportamento agressivo e maior tendência para a recorrência e metástase. Nós apresentamos um caso clínico relatado recentemente em nossa unidade. (Source: Revista da Associacao Medica Brasileira)



Malignancies in a renal transplant population: The St. Michael's Hospital experience

Tue, 22 Mar 2016 23:00:00 +0100

The objective of this study was to analyze the rate and types of malignancies occurring in the St. Michael's Hospital renal transplant population and to determine whether our results were comparable to those previously published. Methods: After approval by the hospital's research ethic board, review of the records and pathology of the 1584 patients in the renal transplant clinic database patients was performed. The reports dated back to the year 1970. Results: Amongst the 1584 renal transplant patients, 106 patients with 132 dysplastic and malignant posttransplant lesions were identified. The highest incidence amid the malignancies was in nonmelanoma skin malignancies squamous cell carcinoma (SCC), basal cell carcinoma, and Kaposi sarcoma, with a total of 32 patient...



Erratum

Tue, 22 Mar 2016 06:34:12 +0100

Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma (Source: Journal of Investigative Dermatology)



Survival with nonmelanoma skin cancer in Germany

Tue, 22 Mar 2016 00:00:00 +0100

ConclusionsA comprehensive overview of NMSC survival in Germany is provided. The differences between the NMSC subtypes require a more differentiated consideration of patient survival. The survival advantage of patients with BCC may be related to health‐promoting factors related to the BCC diagnosis, such as changes to a healthier lifestyle. (Source: British Journal of Dermatology)



Skin Cancer Incidence and Mortality in Spain: A Systematic Review and Meta-Analysis

Mon, 21 Mar 2016 23:00:00 +0100

Conclusions The registration methodology normally used by cancer registries probably underestimates the incidence rates of basal cell and squamous cell carcinoma in Spain. The incidence rates of cutaneous melanoma and Merkel cell carcinoma are lower in Spain than in other European countries. (Source: Actas Dermo-Sifiliograficas)

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A 10-year review of outpatient skin biopsy results and skin cancer subtypes.

Sun, 20 Mar 2016 01:46:01 +0100

Authors: DeMarco SS, Vos P, Green H, Defazio J, Davis N, Fiz L, Phillips C Abstract The results of skin biopsies over a 10 year period were reviewed from the outpatient dermatology clinic at the Brody School of Medicine in Greenville, North Carolina. This research was conducted because there are very few studies that characterize this information over a long-term horizon. The biopsy rate per patient encounter, the clinical reason for the biopsy, the biopsy outcomes, the distribution of cutaneous malignancies per encounter, and the distribution of the subtypes of basal cell carcinoma, squamous cell carcinoma, and melanoma were analyzed. Biopsy logs from January 1, 2001 to December 31, 2010 were reviewed. Our investigation found that 20% of patient encounters resulted in a biopsy. Of...



Clinicopathological analysis of recurrent basal cell carcinoma of the eyelid.

Sat, 19 Mar 2016 21:41:02 +0100

CONCLUSIONS: Proper clinical and pathological evaluation to determine the risk of relapse in BCCs of the eyelids and surrounding structures should include the analysis of prognostic factors, in particular location and size, histopathological type and radicalness of surgical treatment of primary BCCs. Clinical and pathological analysis of patients with recurrent BCC of the eyelids and surrounding structures should be combined with the evaluation of proliferation index Ki-67, which is essential for prognosis and choice of the appropriate therapeutic method. PMID: 26985178 [PubMed] (Source: Advances in Dermatology and Allergology)






The Role of Epidermal Stem Cells in the Origin of Basal Cell Carcinoma

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: Available online 19 March 2016 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): L. Prieto-Torres, S. Hernández-Ostiz, E. Pelegrina-Fernández, C. Conejero del Mazo (Source: Actas Dermo-Sifiliograficas)



Electronic brachytherapy for superficial and nodular basal cell carcinoma: a report of two prospective pilot trials using different doses.

Fri, 18 Mar 2016 12:32:02 +0100

CONCLUSIONS: Our initial experience with Esteya(®) EB system to treat superficial and nodular BCC shows that a dose of 36.6 Gy and 42 Gy delivered in 6 fraction of 7 Gy achieves a 90% and 95% clinical cure rate at 1 year, respectively. Both groups had a tolerable toxicity and a very good cosmesis. The role of EBT in the treatment of BCC is still to be defined. It will probably become an established option for selected patients in the near future. PMID: 26985197 [PubMed] (Source: Journal of Contemporary Brachytherapy)

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Imiquimod induces ER stress and Ca(2+) influx independently of TLR7 and TLR8.

Thu, 17 Mar 2016 23:00:00 +0100

Authors: Nyberg WA, Espinosa A Abstract Endoplasmic reticulum (ER) stress is a physiological response to protein overload or misfolded proteins in the ER. Certain anti-cancer drugs, e.g. bortezomib and nelfinavir, induce ER stress implying that this could be a successful therapeutic strategy against several forms of cancer. To find novel ER-stress inducers we screened a panel of natural and synthetic Toll-like receptor (TLR) agonists against human keratinocytes and identified the anti-cancer drug imiquimod (IMQ) as a potent inducer of ER stress. Other TLR7 and TLR8 agonists, including resiquimod and gardiquimod, did not induce ER stress, demonstrating that IMQ induces ER stress independently of TLR7 and TLR8. We further confirmed this by showing that IMQ could still induce ER stres...



Nanostructured lipid Carrier in Photodynamic therapy for the treatment of Basal Cell Carcinoma.

Thu, 17 Mar 2016 19:31:02 +0100

Authors: Qidwai A, Khan S, Md S, Fazil M, Baboota S, Narang JK, Ali J Abstract Topical photodynamic therapy (PDT) is a promising alternative for malignant skin diseases such as basal cell carcinoma (BCC), due to its simplicity, enhanced patient compliance and localization of the residual photosensitivity to the site of application. However, insufficient photosensitizer penetration into the skin is the major issue of concern with topical PDT. Therefore, the aim of the present study was to enable penetration of photosensitizer to the different strata of the skin using a lipid nanocarrier system. We have attempted to develop a nanostructured lipid carrier (NLC) for the topical delivery of second generation photosensitizer, 5-amino levulinic acid (5-ALA), whose hydrophilicity and charg...



Skin cancer risk in outdoor workers: a European multicenter case–control study

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionsOutdoor workers had more risk behaviour with similar constitutional skin cancer risk factors: more UV exposure (both occupational and leisure) and less sunscreen use and lower health literacy. This results in higher exposure, more photodamage and an increased risk of developing AK, BCC and SCC. (Source: Journal of the European Academy of Dermatology and Venereology)



The experience of a tertiary referral centre in Romania on basal cell carcinomas in outdoor workers: why to assess?

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionOur data suggest that in Romania patients diagnosed with basal cell carcinoma, occupationally exposed to UV radiation, develop more frequently lesions on the “mask area” of the face; furthermore, prediction of the histo‐pathologically aggressive lesions may be supported by the presence of occupational UV exposure and anatomical site (mask zone, cheek and torso) involved.Also, these patients may be at a higher risk to develop more aggressive histologic subtype BCCs. Although limited by a number of factors, especially the small number of subjects, these data suggest the necessity of conducting both retrospective and prospective studies on clinical and histological types of BCCs evolving in patients working outdoor along with identifying additional risk factors. (Source: Journ...



Farmers develop more aggressive histologic subtypes of basal cell carcinoma. Experience from a Tertiary Hospital in Northern Greece

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionOur results indicate a higher risk of earlier development of more aggressive histological subtypes of BCCs in farmers. Photodamage was also more common in this group. Primary and secondary prevention strategies focusing on outdoor workers, including farmers, are mandatory. (Source: Journal of the European Academy of Dermatology and Venereology)

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Questionnaire‐based evaluation of occupational and non‐occupational solar radiation exposure in a sample of Italian patients treated for actinic keratosis and other non‐melanoma skin cancers

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionResults of the original questionnaire developed are coherent with current knowledge and confirm the important role of UV exposure, both occupational and recreational, in the development of AK and NMSCs. Data support the hypothesis that this questionnaire can be applied as useful tool for the evaluation of cumulative UV exposure in future epidemiological studies. (Source: Journal of the European Academy of Dermatology and Venereology)






The European Status Quo in legal recognition and patient‐care services of occupational skin cancer

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionThis survey highlights the need for mandatory regulations on the prevention, management and potential compensation of work‐related UV‐induced skin cancer across Europe. Against the background of a joint European domestic market, equal standards of occupational safety across Europe should include binding regulations for the protection and management of work‐related skin cancer. The design of a common regulation to meet the increasing incidence of skin cancers in outdoor workers should become part of the European agenda, ensuring equal working and living conditions in the member states. (Source: Journal of the European Academy of Dermatology and Venereology)



Injection Site Lichenoid Dermatitis Following Pneumococcal Vaccination: Report and Review of Cutaneous Conditions Occurring at Vaccination Sites

Wed, 16 Mar 2016 23:00:00 +0100

Conclusions Dermatoses at the injection sites of vaccines can be granulomatous, immunity-related conditions, infections, lichenoid, neutrophilic, or pseudolymphomatous. Basal cell carcinoma and squamous cell carcinoma are the most common vaccination site-associated malignancies; however, melanoma and sarcomas (dermatofibrosarcoma protuberans, fibrosarcoma, and malignant fibrous histiocytoma) are also smallpox vaccine-related site neoplasms. A cutaneous immunocompromised district that is created by vaccine-induced local immunologic changes is hypothesized to be the pathogenesis of vaccination site reactions. (Source: Dermatology and Therapy)



Does biopsy accurately assess basal cell carcinoma (BCC) subtype?

Tue, 15 Mar 2016 18:08:08 +0100

To the Editor: The treatment of choice for basal cell carcinoma (BCC) is predominantly based on the histologic subtype, location, and tumor size.1,2 (Source: Journal of the American Academy of Dermatology)

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Poor Sun Protection Practices in Hispanic Patients Increases Risk for Skin Cancer

Mon, 14 Mar 2016 15:03:50 +0100

The most common type of skin cancer in Hispanic patients is basal cell carcinoma, according to Maritza Perez, MD, Associate Clinical Professor of Dermatology at the Icahn School of Medicine at Mount... (Source: Cutis: Cutaneous Medicine for the Practitioner)



Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome)

Mon, 14 Mar 2016 00:00:00 +0100

Abstract Nevoid basal cell carcinoma syndrome, or basal cell nevus syndrome (Gorlin syndrome), is a rare autosomal dominantly inherited disorder that is characterized by development of basal cell carcinomas from a young age. Other distinguishing clinical features are seen in a majority of patients, and include keratocystic odontogenic tumors (formerly odontogenic keratocysts) as well as dyskeratotic palmar and plantar pitting. A range of skeletal and other developmental abnormalities are also often seen. The disorder is caused by defects in hedgehog signaling which result in constitutive pathway activity and tumor cell proliferation. As sporadic basal cell carcinomas also commonly harbor hedgehog pathway aberrations, therapeutic agents targeting key signaling constituents have bee...



Noninvasive imaging for nonmelanoma skin cancer.

Sat, 12 Mar 2016 07:01:02 +0100

Authors: Giavedoni P, Puig S, Carrera C Abstract The development of noninvasive optical technologies is revolutionizing the diagnosis of skin tumors. Nonmelanoma skin cancer, the most frequent neoplasm, has become an important health and economic issue, and proper management can avoid unnecessary morbidity and mutilating treatment or relapses. Noninvasive treatment modalities and the recently approved systemic therapies for advanced basal cell carcinoma cases make noninvasive monitoring techniques necessary. Current knowledge, applications, and limitations of the tools most clinically implemented, such as dermoscopy, reflectance confocal microscopy, high frequency ultrasonography, and optical coherence tomography will be reviewed in this article. In addition to the improvement of d...



Peripheral ameloblastoma of the mandible: A case report

Sat, 12 Mar 2016 00:00:00 +0100

Publication date: Available online 10 March 2016 Source:Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Author(s): Takahiro Kaneko, Satoshi Nakamura, Ryutarou Kawano, Norio Horie, Tetsuo Shimoyama The extra-osseous/peripheral ameloblastoma (PA) is a relatively rare subtype of ameloblastoma, which develops in the soft tissues of the gingiva and oral mucosa. In this article, we describe a PA found in the gingiva of the right mandibular premolar region in a 70-year-old male. On oral examination, a firm, pedunculated mass with a granular surface and partial ulceration was found on the lingual gingiva of the right mandibular first premolar to the first molar. The pathological diagnosis of the incisional biopsy specimen was highly suspected to be PA with difficulty to d...



Scrotal tumors.

Fri, 11 Mar 2016 03:50:01 +0100

CONCLUSIONS: Scrotal lesions in the elderly should be excised and submitted for pathological examination. The basal cell carcinoma of the scrotum appears as a plaque, nodule or ulcer. Long-term surveillance is recommended for these patients. Leiomyoma of the scrotum is presented as a non-ulcerative nodule and his treatment is complete surgical excision. PMID: 26959967 [PubMed - as supplied by publisher] (Source: Archivos Espanoles de Urologia)

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Lack of efficacy of imiquimod in patients with basal cell carcinoma previously treated with rituximab for B cell lymphoma: two case reports

Fri, 11 Mar 2016 00:00:00 +0100

Conclusions We speculated about the effect of rituximab on B lymphocytes, on a particular population of T cells and on antigen-presenting dendritic cells that may have determined a lower expression of some surface antigens involved in antigen presentation. These cells are the specific targets of imiquimod to promote skin cancer cells apoptosis. A lack of action by imiquimod on skin cancer after treatment with rituximab is likely due to its transitory inhibitory effects on lymphocytes and Langherans cells. Further studies could be useful to understand the mechanism behind the lack of response. (Source: Journal of Medical Case Reports)



Itraconazole targets basal cell carcinoma

Thu, 10 Mar 2016 15:18:54 +0100

WAIKOLOA, HAWAII – The familiar oral triazole antifungal agent itraconazole (Sporanox) is under active investigation for an unexpected use: as adjunctive therapy in patients with locally advanced or... (Source: Internal Medicine News)



Incidence of Atypical Nevi in Olmsted County: An Epidemiological Study

Thu, 10 Mar 2016 00:00:00 +0100

ConclusionThere is no association between atypical nevi and the subsequent development of nonmelanoma skin cancer and MM. Incidence rates of atypical nevi are higher among younger women and older men. The association between degree of atypia and malignant melanoma warrants further study. (Source: Journal of Cutaneous Pathology)



Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma

Thu, 10 Mar 2016 00:00:00 +0100

ConclusionsIn cases with a differential diagnosis of CL and BCC, CK20‐staining of intratumoral Merkel cells has a high positive predictive value for CL but is of low sensitivity. The pattern of CK17 expression is a highly sensitive marker for distinguishing CL from BCC in small samples. (Source: Journal of Cutaneous Pathology)



[Teledermatology in a prison setting: A retrospective study of 500 expert opinions].

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSION: This study provides greater knowledge of dermatological diseases in prison and shows teledermatology to be a tool suited to the specific constraints of this universe, while providing inmates with medical care as close as possible to that of the general population, and it thus helps ensure that their fundamental human rights are upheld. PMID: 26971370 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)

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Reconstruction of orbital exenteration defects with bilobed forehead flap

Wed, 09 Mar 2016 00:00:00 +0100

Abstract To describe the use of bilobed forehead flap for reconstruction of orbital exenteration defect. The medical records of 2 patients in whom orbital exenteration defect repair was performed with bilobed forehead flap were reviewed. In both patients (male, ages 74 and 65 years), extended exenteration was performed because of basal cell carcinoma infiltrating the upper and lower eyelids and orbit. One patient had a history of multiple eyelid surgeries and periorbital radiotherapy. In the other, the tumor also involved the maxillary and ethmoid sinuses and nasal dorsum. The bilobed flap was combined with a cheek advancement flap in 1 patient. The excisional defect could be primarily covered in both patients. In 1 patient, a skin graft was needed to cover the forehead donor are...



Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature

Wed, 09 Mar 2016 00:00:00 +0100

ABSTRACT Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear cells, such as squamous cell carcinoma, basal cell carcinoma, metastatic renal cell carcinoma, and balloon cell malignant melanoma. These diagnoses can be ruled out by the typical immunohistochemical profile of clear cell AFX, which is negative for specific epithelial and melanocytic markers. Herein, we describe a rare and unusual case of clear cell AFX arising o...



Morphoeic basal cell carcinoma with ring‐form ulceration

Wed, 09 Mar 2016 00:00:00 +0100

(Source: International Journal of Dermatology)



Head and neck tumours: illustrated

Mon, 07 Mar 2016 08:26:34 +0100

Presentations of head and neck tumours including basal cell carcinoma and squamous cell carcinoma. (Source: GP Online Education)



Skin cancer: To each tumor its particularities, to each tumor its treatment

Mon, 07 Mar 2016 05:00:00 +0100

(Université de Genève) 90 percent of the population are at risk to develop a skin cancer, called basal cell carcinoma, one day. Although common, this cancer is rarely fatal and has until now been little studied. But geneticists sequenced the DNA of these skin tumors, in order to determine the genes that are responsible for the cancerogenesis. Their discovery of new cancer genes that cause BCC can pave the way for new treatment methods personalized for each tumor. (Source: EurekAlert! - Cancer)

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Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

Sun, 06 Mar 2016 23:00:00 +0100

Nature Genetics 48, 398 (2016). doi:10.1038/ng.3525 Authors: Ximena Bonilla, Laurent Parmentier, Bryan King, Fedor Bezrukov, Gürkan Kaya, Vincent Zoete, Vladimir B Seplyarskiy, Hayley J Sharpe, Thomas McKee, Audrey Letourneau, Pascale G Ribaux, Konstantin Popadin, Nicole Basset-Seguin, Rouaa Ben Chaabene, Federico A Santoni, Maria A Andrianova, Michel Guipponi, Marco Garieri, Carole Verdan, Kerstin Grosdemange, Olga Sumara, Martin Eilers, Iannis Aifantis, Olivier Michielin, Frederic J de Sauvage, Stylianos E Antonarakis & Sergey I Nikolaev (Source: Nature Genetics)



Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model

Fri, 04 Mar 2016 00:00:00 +0100

We report marked differences in inhibitor potencies between compounds as well as a notable disparity between the G‐protein assay and the cellular tests, suggesting that classification of drugs is assay dependent. Furthermore, we explored topical efficacies of SMO antagonists on depilated mice using Gli1 and Ptch1 mRNA quantification in skin as biomarkers of the HH signaling inhibition. This topical model rapidly discriminated drugs in terms of efficacies and potencies for inhibition of both biomarkers. SMO antagonists showed also a large variation in their blood and skin partition, suggesting that some drugs are more favorable for topical application. Overall, our data suggested that in vitro and in vivo efficacious drugs such as LEQ‐506 and TAK‐441 may be of interest for topical t...



Sex hormones and the risk of keratinocyte cancers among women in the United States: A population‐based case‐control study

Thu, 03 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



Hereditary non-BRCA gynaecological tumors.

Wed, 02 Mar 2016 16:12:02 +0100

Authors: Vellone VG, Paudice M, Varesco L Abstract Early diagnosis and proper management of gynecologic malignancies represent a challenge in modern oncology. A growing interest has arisen around the gynecological manifestations of hereditary cancer syndromes. In particular, the discovery of the BRCA1 and BRCA2 genes in ovarian cancer and the mismatch repair genes (MMR) in endometrial carcinoma has revolutionized our approach to the diagnosis and screening of women for ovarian and uterine cancers. The clinical, genetic and pathological features of hereditary cancer syndromes with gynecological manifestations are reviewed focusing on Lynch Syndrome, also known as Hereditary Nonpolyposis Colorectal Carcinoma (HNPCC), Peutz-Jeghers Syndrome, Cowden Syndrome or Multiple Hamartoma Syndr...



New technique for bloodless surgery to the scalp

Wed, 02 Mar 2016 00:00:00 +0100

Skin cancers such as malignant melanoma, squamous cell carcinoma, and basal cell carcinoma are common on the scalp,1 and the usual treatment is wide local excision with disease- free margins. Margins vary depending on the type of cancer, the size and depth of invasion, and the cytological findings, as described in the British Association of Dermatology guidelines.2 (Source: The British Journal of Oral and Maxillofacial Surgery)

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Superficial basal cell carcinoma on the face is a diagnostic challenge

Tue, 01 Mar 2016 00:00:00 +0100

Joydeep Singha, Naval PatelIndian Journal of Dermatology 2016 61(2):236-236Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. The incidence of BCC is rising. The nodular, superficial spreading, and infiltrating variants are the three most commonly encountered types of BCC in descending order of prevalence. Superficial spreading basal cell carcinoma (SSBCC) accounts for 15-26% of all cases of BCC. It usually occurs on the trunk and upper extremities, but may be seen on the face. Surgical excision is the most commonly used treatment for BCC. Topical chemotherapy agents such as imiquimod or 5-fluorouracil (5-FU) may be various alternatives or adjuvants in the treatment of SSBCC. characteristically shows areas of uninvolved skin between tumor nests.[7] (Source: ...



Congenital Mirror Movements in Gorlin Syndrome: A Case Report With DTI and Functional MRI Features

Tue, 01 Mar 2016 00:00:00 +0100

Congenital mirror movements are rare conditions that define the inability to perform unimanual movements. Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome, is a genetic disorder with multiple nevi predisposing to basal cell carcinoma, odontogenic keratocysts, and skeletal malformations. Herein we report on an adolescent patient with Gorlin syndrome and coexisting congenital mirror movements. To our knowledge, this is the first patient in the literature who has both of these very rare conditions. (Source: PEDIATRICS)



Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis.

Tue, 01 Mar 2016 00:00:00 +0100

Authors: Li C, Athar M Abstract This commentary summarizes studies showing risk of basal cell carcinoma (BCC) development in relationship to environmental, occupational and therapeutic exposure to ionizing radiation (IR). BCC, the most common type of human cancer, is driven by the aberrant activation of hedgehog (Hh) signaling. Ptch, a tumor suppressor gene of Hh signaling pathway, and Smoothened play a key role in the development of radiation-induced BCCs in animal models. Epidemiological studies provide evidence that humans exposed to radiation as observed among the long-term, large scale cohorts of atomic bomb survivors, bone marrow transplant recipients, patients with tinea capitis and radiologic workers enhances risk of BCCs. Overall, this risk is higher in Caucasians than oth...



Basal Cell Carcinoma of the Nipple in a Male Patient: A Particular Case Report

Mon, 29 Feb 2016 00:00:00 +0100

We report a case of BCC of the right nipple–areola complex in a 75‐year‐old man, treated with Mohs surgery and simple mastectomy. (Source: The Breast Journal)



Preoperative prediction of histopathologic outcome in basal cell carcinoma – flat surface and multiple small erosions predict superficial basal cell carcinoma in lighter skin types

Sat, 27 Feb 2016 00:00:00 +0100

ConclusionsThe study shows a high accuracy for an overall diagnosis of BCC and increased accuracy in prediction of sBCC for the period when dermoscopy was applied in all cases. The most discriminating findings for sBCC, based on clinical and dermoscopic features in this fair‐skinned population were a flat surface and multiple small erosions.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Preoperative prediction of histopathologic outcome in basal cell carcinoma - flat surface and multiple small erosions predict superficial basal cell carcinoma in lighter skin types.

Sat, 27 Feb 2016 00:00:00 +0100

CONCLUSIONS: The study shows a high accuracy for an overall diagnosis of BCC and increased accuracy in prediction of sBCC for the period when dermoscopy was applied in all cases. The most discriminating findings for sBCC, based on clinical and dermoscopic features in this fair-skinned population were a flat surface and multiple small erosions. This article is protected by copyright. All rights reserved. PMID: 26921200 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)



P3: burden of pediatric basal cell carcinoma nevus syndrome on the patients and families from the perspectives of parents and guardians

Thu, 25 Feb 2016 00:00:00 +0100

Conclusions It is our hope that these results will help clinicians be aware of the possible diagnosis of BCCNS at earlier ages in these children. An earlier diagnosis could provide the social and medical specialty-specific support services that may prevent the development of psychosocial and other medical consequences that arise from the burden of disease of BCCNS. (Source: Journal of Investigative Medicine)



Metastatic basal cell carcinoma: case series and review of the literature

Wed, 24 Feb 2016 00:00:00 +0100

Abstract Metastatic basal cell carcinoma is exceedingly uncommon, with a poorly defined natural history, and its incidence, risk factors, patterns of spread, prognosis and potential treatment options are not well understood. This retrospective single institution case series aims to shed light on these issues. Aggressive local management in patients with locoregional disease may result in long‐term survivors. (Source: Australasian Journal of Dermatology)



Hedgehog Blockade for Basal Cell Carcinoma

Wed, 24 Feb 2016 00:00:00 +0100

Hedgehog inhibitors, more accurately known as smoothened inhibitors (SIs), were introduced for the treatment of basal cell carcinoma (BCC) with much success. The clinical data supported the intriguing rationale of interfering with a tumor driver (overactive Sonic Hedgehog signaling in BCC) that was identified 20 years ago. Beyond the well-established surgical or conservative (radiotherapy) treatment options, treatment with SIs now represents a novel avenue the dermato-oncologist can take when surgery or radiotherapy of BCC is contraindicated. This extension of the therapeutic armamentarium for advanced BCC, which is currently used in patients with highly advanced tumors or basal cell nevus syndrome, has also suggested using vismodegib or sonidegib treatment in a neoadjuvant setting. Howeve...



Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for BCC

Wed, 24 Feb 2016 00:00:00 +0100

This case-control study evaluates the risk of developing a non–basal cell carcinoma malignancy after smoothened inhibitor exposure in patients with basal cell carcinoma. (Source: JAMA Dermatology)

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Metastatic basal cell carcinoma: case series and review of the literature.

Wed, 24 Feb 2016 00:00:00 +0100

Authors: Tang S, Thompson S, Smee R Abstract Metastatic basal cell carcinoma is exceedingly uncommon, with a poorly defined natural history, and its incidence, risk factors, patterns of spread, prognosis and potential treatment options are not well understood. This retrospective single institution case series aims to shed light on these issues. Aggressive local management in patients with locoregional disease may result in long-term survivors. PMID: 26916335 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)



Expression of stem cell markers in skin and adnexal malignancies

Tue, 23 Feb 2016 00:00:00 +0100

In conclusion, the expression of potential stem cell markers of the epidermis and hair follicles was observed in skin tumors of appendages and BCCs. However, during tumor progression, many of these markers seemed to be downregulated. This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)



Expression of stem cell markers in skin and adnexal malignancies.

Tue, 23 Feb 2016 00:00:00 +0100

In conclusion, the expression of potential stem cell markers of the epidermis and hair follicles was observed in skin tumors of appendages and BCCs. However, during tumor progression, many of these markers seemed to be downregulated. This article is protected by copyright. All rights reserved. PMID: 26914519 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)



Sonidegib (Odomzo) for Basal Cell Carcinoma

Mon, 22 Feb 2016 13:43:03 +0100

Date:  February 29, 2016 Issue #:  1489 Summary:  The FDA has approved the hedgehog pathway inhibitor sonidegib (Odomzo – Novartis) for oral treatment of locally advanced basal cell carcinoma that cannot be treated with surgery or radiation or has recurred following such treatment. Vismodegib (Erivedge), another oral hedgehog pathway inhibitor, was approved earlier for the same indication and also for treatment of metastatic basal cell carcinoma. (Source: The Medical Letter)



Basal Cell Carcinoma or Trichoblastoma Dermoscopic Examination of Black Macules Developing in the Same Nevus Sebaceus

Mon, 22 Feb 2016 08:39:54 +0100

Nevus sebaceus (NS) is a common congenital birthmark, and various tumors have been reported to develop in NS. Basal cell carcinoma (BCC) seldom occurs in NS, and it is very important to be able to clinicopathologically distinguish BCC from trichoblastoma. Herein, we describe a case of BCC and trichoblastoma occurring simultaneously in the same NS, including the differential dermoscopic features. BCC is clinically difficult to distinguish from trichoblastoma because the clinical manifestations are similar. In a dermoscopic examination of BCC, arborizing vessels are one of the diagnostically significant features. In our case, the BCC showed ‘multiple' black structures, and the trichoblastoma showed a ‘single' black structure without arborizing vessels. To the best of our knowledge, there...

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Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.

Sun, 21 Feb 2016 01:39:02 +0100

Authors: Tang L, Yi XM, Chen J, Chen FJ, Lou W, Gao YL, Zhou J, Su LN, Xu X, Lu JQ, Ma J, Yu N, Ding YF Abstract Melanoma is the most aggressive type of skin cancer, exhibiting extensive local invasion and early distant metastasis. Aberrant expression of ubiquitin-protein ligase E3C (UBE3C) plays a key role in tumor development and progression. In the present study, we analyzed UBE3C expression in samples of cancerous and normal skin tissue. Levels of UBE3C expression were much higher in primary and metastatic melanoma tissues than in normal skin, cutaneous squamous cell carcinoma or basal cell carcinoma. Melanoma cells overexpressing UBE3C frequently exhibited a mesenchymal phenotype, including reduced expression of the epithelial marker E-cadherin and expression of the mesenchyma...



Basal Cell Carcinoma or Trichoblastoma? Dermoscopic Examination of Black Macules Developing in the Same Nevus Sebaceus

Sat, 20 Feb 2016 19:41:25 +0100

Nevus sebaceus (NS) is a common congenital birthmark, and various tumors have been reported to develop in NS. Basal cell carcinoma (BCC) seldom occurs in NS, and it is very important to be able to clinicopathologically distinguish BCC from trichoblastoma. Herein, we describe a case of BCC and trichoblastoma occurring simultaneously in the same NS, including the differential dermoscopic features. BCC is clinically difficult to distinguish from trichoblastoma because the clinical manifestations are similar. In a dermoscopic examination of BCC, arborizing vessels are one of the diagnostically significant features. In our case, the BCC showed ‘multiple' black structures, and the trichoblastoma showed a ‘single' black structure without arborizing vessels. To the best of our knowledge, there...



Usefulness of 18F-FDG PET/CT in recurrent basal cell carcinoma: Report of a case

Sat, 20 Feb 2016 00:00:00 +0100

Publication date: March–April 2016 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), Volume 35, Issue 2 Author(s): S. Ayala, P. Perlaza, S. Puig, E. Prats, S. Vidal-Sicart We analyze the case of a patient with left periorbital infiltrating basal cell carcinoma treated with surgical excision in October 2010. Surgery included orbital exenteration and reconstruction using skin graft and radiotherapy. In May 2013 a MR imaging showed a mass in the left orbital fossa, suggesting a recurrence in the graft. A basal cell carcinoma recurrence with perineural invasion was confirmed in the biopsy. On 18F-FDG PET/CT performed, a hypermetabolic activity was observed in the left periorbital area with extension to surrounding sinus and bones. The use of 18F-FDG PE...



Trichoadenoma of the upper lip.

Fri, 19 Feb 2016 17:31:01 +0100

CONCLUSION: Because the lesion is unique, it is uncertain how aggressive or indolent the tumor might be. Therefore, the microscopical analysis is mandatory. At the best of our knowledge, this is the second case of trichoadenoma of the lip. PMID: 26879403 [PubMed - in process] (Source: Stomatologija)



Automated registration of optical coherence tomography and dermoscopy in the assessment of sub-clinical spread in basal cell carcinoma.

Fri, 19 Feb 2016 15:56:06 +0100

Authors: Coleman AJ, Penney GP, Richardson TJ, Guyot A, Choi MJ, Sheth N, Craythorne E, Robson A, Mallipeddi R Abstract Optical coherence tomography (OCT) has been shown to be of clinical value in imaging basal cell carcinoma (BCC). A novel dual OCT-video imaging system, providing automated registration of OCT and dermoscopy, has been developed to assess the potential of OCT in measuring the degree of sub-clinical spread of BCC. Seventeen patients selected for Mohs micrographic surgery (MMS) for BCC were recruited to the study. The extent of BCC infiltration beyond a segment of the clinically assessed pre-surgical border was evaluated using OCT. Sufficiently accurate (<0.5 mm) registration of OCT and dermoscopy images was achieved in 9 patients. The location of the OCT-assessed ...

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Evaluation of the risk of post-operative bleeding complications in skin cancer surgery without interruption of anticoagulant/antithrombotic medication: A prospective cohort study.

Thu, 18 Feb 2016 04:08:02 +0100

CONCLUSION: Skin cancer surgery can be safely performed without discontinuation of AC/AT treatment, since the risk of postoperative bleeding is statistically insignificant. PMID: 25835043 [PubMed - in process] (Source: Journal of Plastic Surgery and Hand Surgery)



Basosquamous carcinoma: is it an aggressive tumor?

Thu, 18 Feb 2016 04:08:02 +0100

Authors: Kececi Y, Argon A, Kebat T, Sir E, Gungor M, Vardar E Abstract Basosquamous carcinoma is a rare cutaneous tumour that is considered an aggressive type of basal cell carcinoma with an increased risk of recurrence and metastases. This impression has been perpetuated in the literature, despite limited scientific data and conflicting results of some authors. This present study was aimed to evaluate the clinical-pathological features of this tumour and follow-up of a series of basosquamous carcinoma. Basosquamous carcinoma patients who underwent surgical excision between January 2000 and February 2012 were analyzed retrospectively. Their medical files were reviewed and the corresponding routinely stained sections (with hematoxylin-eosin) were re-evaluated by two pathologists. T...



Maxillary plexiform ameloblastoma showing basaloid differentiation: Report of a rare case with review of literature

Thu, 18 Feb 2016 00:00:00 +0100

Sravani Ghattamaneni, Venkateswara Rao Guttikonda, M Geetha Kumari, D Rakesh KumarIndian Journal of Dental Research 2015 26(6):633-636Ameloblastoma is a benign, locally aggressive tumor originating from the odontogenic epithelium. It manifests as a slow growing swelling, causing expansion of the jaw bones. Radiologically, it presents as a unilocular or multilocular radiolucency exhibiting a characteristic soap bubble or honeycomb appearance. Ameloblastoma exhibits several histologic patterns of which basal cell variant is a rare entity. The present case report is that of a maxillary ameloblastoma exhibiting a basaloid differentiation that may put one in the mind of a basaloid squamous cell carcinoma or a basal cell carcinoma. Confirmation of such rare variants should be done not only based...



Familial skin cancer syndromes

Wed, 17 Feb 2016 19:09:20 +0100

Nonmelanoma skin cancers (NMSCs) represent the most common malignancies worldwide, with reported incidence rising each year. Both cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), as well as other NMSCs, represent complex diseases with a combination of environmental and genetic risk factors. In general, hereditary cancer syndromes that increase the risk of NMSC fall under several broad categories: those associated with immunodeficiencies, those that affect skin pigmentation, and those that perturb key molecular pathways involved in the pathogenesis of NMSCs. (Source: Journal of the American Academy of Dermatology)



Emerging drugs and combination strategies for basal cell carcinoma.

Wed, 17 Feb 2016 17:44:02 +0100

Authors: Dreier J, Dummer R, Felderer L, Nägeli M, Gobbi S, Kunstfeld R Abstract INTRODUCTION: Basal cell carcinoma (BCC) is a malignancy that is driven by an activated Hedgehog (Hh) pathway. Smoothened inhibitors are a new promising treatment option for patients with locally advanced or metastatic BCC or basal cell nevus syndrome. But long-term data are still limited, the optimal treatment duration is not yet defined and there are already documented cases with acquired resistance. AREAS COVERED: Treatment modalities with Hh inhibitors, side effects and potential pharmacological combination options are discussed. The current literature, including PubMed, Cochrane database and registered trials on ClinicalTrials.gov, was searched. EXPERT OPINION: BCCs typically regress duri...

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Heterozygous PTCH1 Mutations Impact the Bone Metabolism in Patients with Nevoid Basal Cell Carcinoma Syndrome Likely by Regulating SPARC Expression

Wed, 17 Feb 2016 00:00:00 +0100

This study sought to investigate the mechanism underlying heterozygous PTCH1 mutation‐mediated abnormal bone metabolism in patients with NBCCS. Stromal cells were isolated from the fibrous capsules of patients with NBCCS‐associated or non‐syndromic keratocystic odontogenic tumors and non‐syndromic tumor stromal cells without PTCH1 mutations served as controls. Germline PTCH1 heterozygous mutations were confirmed in all NBCCS samples and differential protein expression was identified using tandem mass tag‐labeled proteomics analysis. Our findings revealed that osteonectin/SPARC expression was significantly downregulated in syndromic stromal cells compared with non‐syndromic stromal cells. SPARC expression was even lower in stromal cells carrying PTCH1 protein truncation mutation...



Melanoma and non-melanoma skin cancer in psoriatic patients treated with high-dose phototherapy.

Tue, 16 Feb 2016 03:23:09 +0100

CONCLUSIONS: A noteworthy number of NMSC were diagnosed in this Mediterranean population of patients exposed to high-dose UV treatment. A thorough risk-benefit evaluation should always be done before UV treatment and patients should be carefully monitored for skin cancer during and after treatment discontinuation. PMID: 26822468 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)



The reflectance confocal microscopy in diagnosis of recurrent basal cell carcinoma.

Tue, 16 Feb 2016 03:23:09 +0100

CONCLUSION: RCM is a diagnostic tool with a high PPV, sensitivity and specificity for the diagnosis of recurrence of BCC lesions. PMID: 26325338 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)



A massive neglected giant basal cell carcinoma in a schizophrenic patient treated successfully with vismodegib.

Tue, 16 Feb 2016 03:23:09 +0100

We present a case of a 73-year-old schizophrenic patient with a 15-year history of a neglected tumour located at the forehead and scalp, admitted to hospital in a state of inanition because of tumour expansion to the meninges and severe anaemia caused by bleeding, treated successfully with vismodegib. PMID: 25909367 [PubMed - in process] (Source: Journal of Dermatological Treatment)



Postepy Hig Med Dosw 2016; 70:86-94 "Carcinogenic viruses in etiopathogenesis of skin cancers in patients after organ transplantation"

Mon, 15 Feb 2016 01:15:49 +0100

The latest literature report specifies multifactoral etiology of skin cancer in population of patients after organs transplats. Carcirogenic viruses are one of etiopathogenesis components. Viruses of a vital meaning for skin oncogenesis are called Human papillomavirus – HPV, Human herpesvirus 8 – HHV8 i Merkel cell polyomavirus – MCV. Report on connections exisisting between viruses HPV and skin cancers in the population of patients after organs transplants confirms clinical connection between viruses papillas and cancers centres occuring in similar locations and more frequent appearance of attributes characteristic for HPV infection within the limits of changes in the type of Squamous cell carcinoma (SCC). What’s more, coexisting of viruses papillas and SCC is more often noticed i...

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Cancers, Vol. 8, Pages 22: Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

Mon, 15 Feb 2016 00:00:00 +0100

The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and cancers of the breast, lung, pancreas, and prostate. Tumorigenesis, tumor progression and therapeutic response have all been shown to be impacted by the Shh signaling pathway. Downstream effectors of the Shh pathway include smoothened (SMO) and glioma-associated oncogene homolog (GLI) family of zinc finger transcription factors. Both are regarded as important targets for cancer therapeutics. While most efforts have been devoted towards pharmacologically targeting SMO, developing GLI-targeted appr...



Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer

Mon, 15 Feb 2016 00:00:00 +0100

Transcriptional and splicing anomalies have been observed in intron 8 of the CASP8 gene (encoding procaspase-8) in association with cutaneous basal-cell carcinoma (BCC) and linked to a germline SNP rs700635. Here, we show that the rs700635[C] allele, which is associated with increased risk of BCC and breast cancer, is protective against prostate cancer [odds ratio (OR) = 0.91, P = 1.0 x 10–6]. rs700635[C] is also associated with failures to correctly splice out CASP8 intron 8 in breast and prostate tumours and in corresponding normal tissues. Investigation of rs700635[C] carriers revealed that they have a human-specific short interspersed element-variable number of tandem repeat-Alu (SINE-VNTR-Alu), subfamily-E retrotransposon (SVA-E) inserted into CASP8 intron 8. The SVA-E shows evi...



Basaloid Squamous Cell Carcinoma of the Anus Revisited

Sat, 13 Feb 2016 09:35:06 +0100

Basaloid squamous cell carcinoma (SCC) of the anus, previously called cloacogenic carcinoma, is a subtype of SCC. There are very few data on the morphologic variation within basaloid SCC of the anus, which may contribute to misdiagnosis. We retrospectively evaluated cases originally diagnosed as basaloid SCC for histologic characterization. We retrieved and reviewed cases of basaloid SCC from 1994 to 2013. Ten (27%) cases were reclassified after review, including basal cell carcinoma (n=6), melanoma (n=2), and neuroendocrine carcinoma (n=2). The final group of basaloid SCC (n=27) showed a female predominance (median age=60 y; range, 42 to 92 y). Morphologically, basaloid SCC could be categorized into 4 groups: transitional carcinoma like (n=10), basaloid with peripheral palisade (n=13), ad...



Sonidegib: A Review in Locally Advanced Basal Cell Carcinoma

Fri, 12 Feb 2016 00:00:00 +0100

Abstract Sonidegib (Odomzo®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adults with locally advanced basal cell carcinoma (laBCC) who are not candidates for surgery or radiation therapy, or adults with recurrent laBCC following surgery or radiation therapy. In the multicentre BOLT trial, the primary endpoint (i.e., an objective tumour response rate point estimate of ≥30 % and a 95 % confidence interval lower bound of >20 % in patients with fully assessable laBCC and all patients with metastatic BCC) was met at the primary analysis cut-off date (median follow-up 13.9 months) in the sonidegib 200 mg (36 % [95 % CI 24–50]) and 800 mg (34 % [95 % CI 25–43]) once-daily groups. Sonidegib 200 mg once daily (recommended dosage) had a bette...



Is early detection of basal cell carcinoma worthwhile? Systematic review based on the WHO criteria for screening

Fri, 12 Feb 2016 00:00:00 +0100

ConclusionsThe available data point to a slow increase in size of BCC over time. This size is one of the major determinants in the choice of an effective treatment and the associated cost especially for facial BCC. Therefore we conclude that current data support early detection and adequate management of BCCs on the face.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)

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Anti-TNF therapy linked to ‘modest’ extra SCC risk

Thu, 11 Feb 2016 18:36:44 +0100

A Swedish population-based study shows that treatment with tumour necrosis factor inhibitors significantly increases the risk of developing squamous cell carcinoma, but not basal cell carcinoma, in patients with rheumatoid arthritis. (Source: MedWire News)



Giant Fungating Basal Cell Carcinoma of the Scrotum

Thu, 11 Feb 2016 00:00:00 +0100

We present an unusual case of basal cell carcinoma (BCC) arising from a non-sun-exposed area. The patient was 69-year-old male with an enlarging giant fungating mass protruding from his scrotum for which he did not seek medical treatment until recently. The mass did not involve the scrotum or epididymis and was confirmed on ultrasound. He underwent wide surgical excision and was diagnosed with BCC of the scrotum. Scrotal BCC appears to be more aggressive and more likely to metastasize compared to lesions arising from other areas of the body. (Source: Urology)



Limitations of Ber‐EP4 for distinction of Bowen disease from basal cell carcinoma

Wed, 10 Feb 2016 00:00:00 +0100

ConclusionWe conclude that Ber‐EP4 expression is not always helpful to distinguish between Bowen type of SCCIS and BCC, as Ber‐EP4 expression in Bowen type SCCIS is not infrequent. (Source: Journal of Cutaneous Pathology)



Long-noncoding RNAs in basal cell carcinoma

Tue, 09 Feb 2016 00:00:00 +0100

Abstract Long noncoding RNAs (lncRNAs) are fundamental regulators of pre- and post-transcriptional gene regulation. Over 35,000 different lncRNAs have been described with some of them being involved in cancer formation. The present study was initiated to describe differentially expressed lncRNAs in basal cell carcinoma (BCC). Patients with BCC (n = 6) were included in this study. Punch biopsies were harvested from the tumor center and nonlesional epidermal skin (NLES, control, n = 6). Microarray-based lncRNA and mRNA expression profiles were identified through screening for 30,586 lncRNAs and 26,109 protein-coding transcripts (mRNAs). The microarray data were validated by RT-PCR in a second set of BCC versus control samples. Gene ontology (GO) and Kyoto Encyclopedia of Gen...



Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma.

Mon, 08 Feb 2016 13:26:02 +0100

Authors: Warszawik-Hendzel O, Olszewska M, Maj M, Rakowska A, Czuwara J, Rudnicka L Abstract Squamous cell carcinoma is the second most common cutaneous malignancy after basal cell carcinoma. Although the gold standard of diagnosis for squamous cell carcinoma is biopsy followed by histopathology evaluation, optical non-invasive diagnostic tools have obtained increased attention. Dermoscopy has become one of the basic diagnostic methods in clinical practice. The most common dermoscopic features of squamous cell carcinoma include clustered vascular pattern, glomerular vessels and hyperkeratosis. Under reflectance confocal microscopy, squamous cell carcinoma shows an atypical honeycomb or disarranged pattern of the spinous-granular layer of the epidermis, round nucleated bright cells ...

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Is a punch biopsy reliable in subtyping basal cell carcinoma? A systematic review.

Mon, 08 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. PMID: 26854334 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)



Is a punch biopsy reliable in subtyping basal cell carcinoma? A systematic review

Mon, 08 Feb 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)



Defining locally advanced basal cell carcinoma and integrating smoothened inhibitors into clinical practice

Sat, 06 Feb 2016 21:05:53 +0100

Purpose of review: We summarize the concept of a locally advanced basal cell carcinoma (laBCC) and present the current consensus definition. We also review the key pieces of primary research undertaken in the past year and how these affect the use of smoothened inhibitors in a clinical setting. Recent findings: Medium term follow-up (30 months) of patients treated with vismodegib shows an improvement in response rates for patients with laBCC. The safety profile of vismodegib demonstrated in the original ERIVANCE study has been replicated in a larger patient cohort in a repeat study. Sonidegib is a new smoothened inhibitor currently under investigation for treatment of laBCC, which demonstrates a comparable safety profile to vismodegib. The side-effects of smoothened inhibitors appear rela...



Comparative Study of Dermatoscopic and Histopathologic Results in Facial Basal Cell Carcinoma and Melanocytic Nevi.

Fri, 05 Feb 2016 05:23:02 +0100

CONCLUSIONS: Dermatoscopic study not only can be helpful in improving clinical diagnosis while guiding missed malignant lesions to pathologic evaluations, but also could be useful in evaluating further suspicious or recurrent cases. PMID: 26838250 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)



Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

Fri, 05 Feb 2016 00:00:00 +0100

Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair... (Source: Head and Face Medicine)

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Orthovoltage for basal cell carcinoma of the head and neck: Excellent local control and low toxicity profile

Thu, 04 Feb 2016 00:00:00 +0100

ConclusionOrthovoltage therapy for well‐selected favorable BCCs in the head and neck area resulted in excellent local control rates, a low toxicity profile, and apparently satisfactory functional and cosmetic outcomes. Orthovoltage irradiation is a good alternative for surgery for BCCs with favorable histologic prognosis at locations that are at risk for postoperative functional or cosmetic changes, such as the nose or canthus. Level of Evidence4. Laryngoscope, 2016 (Source: The Laryngoscope)



Retrospective Outcome Analysis of 39 Patients Who Underwent Lip Surgery for Cutaneous Carcinoma

Thu, 04 Feb 2016 00:00:00 +0100

Conclusion Differences between the surgical margins and the final histologic margins were the main finding of this retrospective study. These differences were attributed to surgical practices and modification during the histological process. Nevertheless, we did not observe a higher rate of recurrence or death in our study than in literature. (Source: Journal of Maxillofacial and Oral Surgery)



[Management of eyelid carcinomas: Retrospective bicentric study of 64 cases and review of the literature].

Wed, 03 Feb 2016 01:52:02 +0100

CONCLUSION: Malignant tumors of the eyelids, of which basal cell carcinoma is the most common, pose a therapeutic problem where surgery remains the most utilized treatment option. The best treatment is prevention and diagnosis of early lesions to improve prognosis and to avoid worse outcomes. PMID: 26826743 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)



Skin Cancer Incidence and Mortality in Spain: A Systematic Review and Meta-Analysis.

Wed, 03 Feb 2016 00:00:00 +0100

CONCLUSIONS: The registration methodology normally used by cancer registries probably underestimates the incidence rates of basal cell and squamous cell carcinoma in Spain. The incidence rates of cutaneous melanoma and Merkel cell carcinoma are lower in Spain than in other European countries. PMID: 26852370 [PubMed - as supplied by publisher] (Source: Actas Dermo-Sifiliograficas)



Aminolevulinic acid and methyl aminolevulinate equally effective in topical photodynamic therapy for non‐melanoma skin cancers

Wed, 03 Feb 2016 00:00:00 +0100

ConclusionALA‐ and MAL‐PDT appear to be equally effective in the treatment of AK, BD, nBCC and sBCC. Nevertheless, larger, prospective, randomized and controlled studies should be carried out to confirm these results. (Source: Journal of the European Academy of Dermatology and Venereology)

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The Unique Dermoscopic Structure ‘Large black web’ in basal cell carcinoma on the areola

Wed, 03 Feb 2016 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)



Relation of statin use with non-melanoma skin cancer: prospective results from the Women’s Health Initiative

Tue, 02 Feb 2016 00:00:00 +0100

Relation of statin use with non-melanoma skin cancer: prospective results from the Women’s Health Initiative British Journal of Cancer 114, 314 (02 February 2016). doi:10.1038/bjc.2015.376 Authors: Ange Wang, Marcia L Stefanick, Kristopher Kapphahn, Haley Hedlin, Manisha Desai, Jo Ann E Manson, Howard Strickler, Lisa Martin, Jean Wactawski-Wende, Michael Simon & Jean Y Tang (Source: British Journal of Cancer)



Adaptable texture‐based segmentation by variance and intensity for automatic detection of semitranslucent and pink blush areas in basal cell carcinoma

Mon, 01 Feb 2016 00:00:00 +0100

ConclusionThis pilot study indicates that automatic detection of semitranslucent and pink blush areas in BCC is feasible using colors and first‐order texture statistics. (Source: Skin Research and Technology)



Organ transplant recipients face increased risk of BCC

Sun, 31 Jan 2016 21:33:52 +0100

Recipients of a solid organ transplant face up to a sixfold increase in the risk of developing a basal cell carcinoma – a risk that seems to increase as time passes. A pretransplant history of squamous cell carcinoma (SCC) increased this risk to 55 times that seen in the general population, Dr.... (Source: Skin and Allergy News)