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MedWorm: Lymphoma



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Lymphoma category.



Last Build Date: Tue, 29 Mar 2016 16:47:35 +0100

 



Mp63-01 a proposal for a novel peri-operative mortality risk assessment tool in contemporary patients treated with radical cystectomy

Mon, 28 Mar 2016 19:24:08 +0100

The Charlson comorbidity index (CCI) is the most widely used index score in retrospective analyses. However, several comorbid conditions included in this index, such as sever liver disease, AIDS, leukemia/lymphoma, are never seen in patients candidate to radical cystectomy (RC). Some other comorbid conditions, such as diabetes, and chronic pulmonary disease, are very frequently seen. Conversely, other conditions that are not accounted within that CCI index may represent better predictors of perioperative mortality. (Source: The Journal of Urology)

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Idelalisib Speed Bump: Shifting Gears in CLLIdelalisib Speed Bump: Shifting Gears in CLL

Mon, 28 Mar 2016 15:24:46 +0100

Dr Bruce Cheson discusses how the halt of six idelalisib trials because of adverse events, including deaths, affects research and patient management in CLL and follicular lymphoma. Medscape Oncology (Source: Medscape Today Headlines)



Nutritional assessment as predictor of complications after hematopoietic stem cell transplantation

Mon, 28 Mar 2016 14:30:05 +0100

Conclusions: After hematopoietic stem cell transplantation, high catabolism was associated with longer length of hospital stay, the need of total parenteral nutrition and platelet and neutrophil engraftment times. Nutritional parameters were not associated with overall survival. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Hematopoietic progenitor cell mobilization for autologous transplantation - a literature review

Mon, 28 Mar 2016 14:30:05 +0100

ABSTRACT The use of high-dose chemotherapy with autologous support of hematopoietic progenitor cells is an effective strategy to treat various hematologic neoplasms, such as non-Hodgkin lymphomas and multiple myeloma. Mobilized peripheral blood progenitor cells are the main source of support for autologous transplants, and collection of an adequate number of hematopoietic progenitor cells is a critical step in the autologous transplant procedure. Traditional strategies, based on the use of growth factors with or without chemotherapy, have limitations even when remobilizations are performed. Granulocyte colony-stimulating factor is the most widely used agent for progenitor cell mobilization. The association of plerixafor, a C-X-C Chemokine receptor type 4 (CXCR4) inhibitor, to granulocyte c...



Modern techniques of magnetic resonance in the evaluation of primary central nervous system lymphoma: contributions to the diagnosis and differential diagnosis

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Hemolytic vascular inflammation: an update

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)

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Guidelines on the treatment of acute myeloid leukemia: Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Hematological manifestations of human T lymphotropic virus type 1 infection: a possible association with autoimmune myelofibrosis

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



RHD*weak D type 38: a family study

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



A difficult case of angioimmunoblastic T-cell lymphoma to diagnose

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Systemic fungal infection by Histoplasma capsulatum: intracellular fungus in peripheral leukocytes

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)

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What is the adequate mononuclear cell content for selecting umbilical cord blood units for cryopreservation?

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Zika virus and its implication in transfusion safety

Mon, 28 Mar 2016 14:30:05 +0100

This report is a review of the most relevant contributions of nonconventional magnetic resonance techniques to the imaging diagnosis of primary central nervous system lymphoma, the differential diagnosis of this disease, and the prognosis of patients. This paper aims to describe a wide range of presentations of primary central nervous system lymphoma, their appearance in imaging, and the differential diagnoses of this disease. (Source: Revista Brasileira de Hematologia e Hemoterapia)



Trends in primary central nervous system lymphoma incidence and survival in the U.S.

Mon, 28 Mar 2016 14:29:18 +0100

Summary It is suspected that primary central nervous system lymphoma (PCNSL) rates are increasing among immunocompetent people. We estimated PCNSL trends in incidence and survival among immunocompetent persons by excluding cases among human immunodeficiency virus (HIV)‐infected persons and transplant recipients. PCNSL data were derived from 10 Surveillance, Epidemiology and End Results (SEER) cancer registries (1992–2011). HIV‐infected cases had reported HIV infection or death due to HIV. Transplant recipient cases were estimated from the Transplant Cancer Match Study. We estimated PCNSL trends overall and among immunocompetent individuals, and survival by HIV status. A total of 4158 PCNSLs were diagnosed (36% HIV‐infected; 0·9% transplant recipients). HIV prevalence in PCNSL case...



The role of upfront autologous stem cell transplantation in high‐risk younger patients with primary central nervous system lymphoma

Sun, 27 Mar 2016 22:00:00 +0100

Upfront autologous stem cell transplantation (ASCT) has shown favourable outcome in patients with primary central nervous system lymphoma (PCNSL), but the role of risk‐adapted upfront ASCT consolidation has not been evaluated in PCNSL. As PCNSL patients with the International Extranodal Lymphoma Study Group (IELSG) prognostic score ≥2 or those who did not achieve complete response after two courses of induction chemotherapy (non‐CR1) have shown inferior outcomes, we retrospectively analysed the role of upfront ASCT in 66 high‐risk (IELSG ≥2 and/or non‐CR1) younger (age <65 years) immunocompetent PCNSL patients who achieved at least partial response after initial high‐dose methotrexate‐based chemotherapy. Nineteen patients who received upfront ASCT exhibited significantl...



Rituximab, bendamustine and lenalidomide in patients with aggressive B‐cell lymphoma not eligible for anthracycline‐based therapy or intensive salvage chemotherapy – SAKK 38/08

Sun, 27 Mar 2016 22:00:00 +0100

In conclusion, R‐BL can be considered a treatment option for elderly patients with treatment naïve or relapsed/refractory aggressive lymphoma not eligible for standard aggressive regimens. (Source: British Journal of Haematology)

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Activation‐Induced Killer Cell Immunoglobulin‐like Receptor 3DL2 Binding to HLA–B27 Licenses Pathogenic T Cell Differentiation in Spondyloarthritis

Sun, 27 Mar 2016 22:00:00 +0100

ConclusionKIR‐3DL2 binding to HLA–B27 licenses Th17 cell differentiation in SpA. These findings raise the therapeutic potential of targeting HLA–B27–KIR‐3DL2 interactions for the treatment of B27+ patients with SpA. (Source: Arthritis and Rheumatism)



RE: HCV and Lymphoma

Sun, 27 Mar 2016 22:00:00 +0100

(Source: Hepatology)



HCV and Lymphoma

Sun, 27 Mar 2016 22:00:00 +0100

(Source: Hepatology)



STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre‐B Cell Growth in a CCL20‐Dependent Manner

Sun, 27 Mar 2016 22:00:00 +0100

In conclusion, our data supported our hypothesis that STAT5A enhanced the response of pre‐B cells to CCL20 to promote their growth. This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)



Donor monoclonal gammopathy may cause lymphoproliferative disorders in solid organ transplant recipients

Sun, 27 Mar 2016 22:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: American Journal of Transplantation)

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Identification of IgH gene rearrangement and immunophenotype in an animal model of Epstein–Barr virus‐associated lymphomas

Sun, 27 Mar 2016 22:00:00 +0100

In this study, we transplanted normal human peripheral blood lymphocytes (hu‐PBL) from six donors infected with EBV into SCID mice to construct hu‐PBL/SCID chimeric mice. The induced tumors were found in the mediastinum or abdominal cavity of SCID mice. Microscopic observation exhibited tumor cells that were large and had a plasmablastic, centroblastic or immunoblastic‐like appearance. Immunophenotyping assays showed the induced tumors were LCA‐positive, CD20/CD79a‐positive (markers of B cells), and CD3/CD45RO‐negative (markers of T cells). A human‐specific Alu sequence could be amplified by Alu‐PCR. This confirmed that induced tumors were B‐cell lymphomas originating from the transplanted human lymphocytes rather than mouse cells. EBER in situ hybridization detected posi...






Methotrexate-associated orbital lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report

Sun, 27 Mar 2016 22:00:00 +0100

Conclusion This case of orbital MTX-LPD suggests that the possibility of MTX-LPD should be considered even for ocular tumors in patients treated with MTX. (Source: Japanese Journal of Ophthalmology)



Genetics of Bladder Malignant Tumors in Childhood.

Sun, 27 Mar 2016 00:22:02 +0100

Authors: Zangari A, Zaini J, Gulìa C Abstract Bladder masses are represented by either benign or malignant entities. Malignant bladder tumors are frequent causes of disease and death in western countries. However, in children they are less common. Additionally, different features are found in childhood, in which non epithelial tumors are more common than epithelial ones. Rhabdomyosarcoma is the most common pediatric bladder tumor, but many other types of lesions may be found, such as malignant rhabdoid tumor (MRT), inflammatory myofibroblastic tumor and neuroblastoma. Other rarer tumors described in literature include urothelial carcinoma and other epithelial neoplasms. Rhabdomyosarcoma is associated to a variety of genetic syndromes and many genes are involved in tumor developmen...



Targeting childhood, adolescent and young adult non‐Hodgkin lymphoma: therapeutic horizons

Sat, 26 Mar 2016 23:00:00 +0100

Summary Non‐Hodgkin lymphoma (NHL) is the third most common malignancy in children, adolescents and young adults (CAYA). NHL is a diverse set of diseases that arise at key regulatory checkpoints during B or T cell development in the bone marrow, germinal centre or thymus. While advances in the use of conventional cytotoxic agents have led to dramatic improvements in survival, these cures are associated with significant acute and long‐term toxicities. Moreover, the prognosis for CAYA patients with relapsed or refractory NHL remains dismal, with the vast majority dying of their disease. Thanks to a large number of candidate‐based biological studies, together with large‐scale sequencing efforts, there has been an explosion of knowledge regarding the molecular pathophysiology of B‐ a...

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Nonintubated uniportal thoracoscopic surgery for resection of lung lesions.

Sat, 26 Mar 2016 22:10:02 +0100

CONCLUSIONS: Nonintubated uniportal VATS is technically feasible, effective, and safe for diagnosis and treatment of various lung lesions in selected patients. PMID: 27014470 [PubMed] (Source: Journal of Thoracic Disease)



Advances in cancer immunology and cancer immunotherapy.

Sat, 26 Mar 2016 21:34:04 +0100

The objective clinical response observed in patients treated with antibodies that block the immune checkpoints, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell-death protein 1 (PD-1)/programmed cell-death 1 ligand 1 (PD-L1) pathways, has led to their FDA approval for the treatment of melanoma in 2011 and in 2014, respectively. The anti-PD-1 antibody nivolumab has received the FDA-approval in March 2015 for squamous lung cancer treatment. In addition, antibodies targeting PD-1 or PD-L1 have demonstrated their efficacy and safety in additional tumors, including non-small cell lung carcinoma (NSCLC), renal cell carcinoma (RCC), bladder cancer, and Hodgkin's lymphoma. Almost at the same time, the field of adoptive cell transfer has exploded. The chimeric antigen recept...



Exploring the conformational and binding properties of unphosphorylated/phosphorylated monomeric and trimeric Bcl‐2 through docking and molecular dynamics simulations

Sat, 26 Mar 2016 13:34:18 +0100

This article is protected by copyright. All rights reserved. (Source: Biopolymers)



Correlation of Endoscopic Findings of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma with Recurrence after Complete Remission.

Sat, 26 Mar 2016 12:31:01 +0100

Conclusions: In gastric MALT lymphoma, the endoscopically defined polypoid type was characterized by a longer duration to CR, with a higher likelihood of recurrence, compared to the endoscopically defined diffuse infiltration or ulceration types. PMID: 27009028 [PubMed - as supplied by publisher] (Source: Clinical Endoscopy)



Mutational status of EZH2 and CD79B hot spots in mature B-cell non-Hodgkin's lymphomas: novel CD79B variations have been revealed.

Sat, 26 Mar 2016 11:11:03 +0100

CONCLUSIONS: None of the patients had well-known hot spot mutations in EZH2 and CD79B. However, we detected novel CD79B variations in mature B-cell non-Hodgkin's lymphoma patients. PMID: 27010137 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

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Editorial Board

Sat, 26 Mar 2016 06:23:19 +0100

(Source: Clinical Lymphoma, Myeloma and Leukemia)



Table of Contents

Sat, 26 Mar 2016 06:23:19 +0100

(Source: Clinical Lymphoma, Myeloma and Leukemia)



3 CE Test Hours: Cardiotoxicity and Breast Cancer as Late Effects of Pediatric and Adolescent Hodgkin Lymphoma Treatment.

Sat, 26 Mar 2016 06:14:02 +0100

Authors: Contrada E PMID: 27011135 [PubMed - in process] (Source: The American Journal of Nursing)



Twenty-six-week oral carcinogenicity study of 3-monochloropropane-1,2-diol in CB6F1-rasH2 transgenic mice.

Fri, 25 Mar 2016 23:00:00 +0100

Authors: Lee BS, Park SJ, Kim YB, Han JS, Jeong EJ, Son HY, Moon KS Abstract The carcinogenic potential of 3-monochloro-1,2-propanediol (3-MCPD) was evaluated in a short-term carcinogenicity testing study using CB6F1 rasH2-Tg (rasH2-Tg) mice. 3-MCPD is found in many foods and food ingredients as a result of storage or processing and is regarded as a carcinogen since it is known to induce Leydig cell and kidney tumors in rats. Male and female rasH2-Tg mice were administered 3-MCPD once daily by oral gavage at doses of 0, 10, 20, and 40 mg/kg body weight (bw) per day for 26 weeks. As a positive control, N-methyl-N-nitrosourea (MNU) was administered as a single intraperitoneal injection (75 mg/kg). In 3-MCPD-treated mice, there was no increase in the incidence of neoplastic lesions...



TKI sensitivity patterns of novel kinase-domain mutations suggest therapeutic opportunities for patients with resistant ALK+ tumors.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Amin AD, Li L, Rajan SS, Gokhale V, Groysman MJ, Pongtornpipat P, Tapia EO, Wang M, Schatz JH Abstract The anaplastic lymphoma kinase (ALK) protein drives tumorigenesis in subsets of several tumors through chromosomal rearrangements that express and activate its C-terminal kinase domain. In addition, germline predisposition alleles and acquired mutations are found in the full-length protein in the pediatric tumor neuroblastoma. ALK-specific tyrosine kinase inhibitors (TKIs) have become important new drugs for ALK-driven lung cancer, but acquired resistance via multiple mechanisms including kinase-domain mutations eventually develops, limiting median progression-free survival to less than a year. Here we assess the impact of several kinase-domain mutations that arose during...

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Artificial antigen-presenting cells expressing AFP158-166 peptide and interleukin-15 activate AFP-specific cytotoxic T lymphocytes.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Sun L, Guo H, Jiang R, Lu L, Liu T, Zhang Z, He X Abstract Professional antigen-presenting cells (APCs) are potent generators of tumor antigen-specific cytotoxic T lymphocytes (CTLs) for adoptive immunotherapy; however, generation of APCs is cumbersome, expensive, and subject to the tumor microenvironment. Artificial APCs (aAPCs) have been developed as a cost-effective alternative to APCs. We developed a cellular aAPC that efficiently generated alpha-fetoprotein (AFP)-specific CTLs. We genetically modified the human B cell lymphoma cell line BJAB with a lentiviral vector to establish an aAPC called BA15. The expression of AFP158-166-HLA-A*02:01 complex, CD80, CD86, and interleukin (IL)-15 in BA15 cells was assessed. The efficiency of BA15 at generating AFP-specific CTLs an...



Anaplastic lymphoma kinase (ALK) gene alteration in gastric signet ring cell carcinoma.

Fri, 25 Mar 2016 15:40:03 +0100

This study was aimed to investigating the frequency of Anaplastic lymphoma kinase (ALK) alterations in patients with gastric signet ring cell carcinoma (SRC) and the correlations between ALK alterations and the clinical-pathological features. METHODS: The expression of ALK protein was first determined in paraffin-embedded tissue specimens (FFPE) from 177 pathologically confirmed SRC patients by Ventana Immunohistochemistry (IHC). Then patients with ALK positive detected by IHC were assayed in ALK rearrangement by Fluorescence in Situ Hybridization (FISH). RESULTS: We assessed 4 of 177 cases (2.3%) as positive by IHC. 3 of the 4 patients had T4 tumors and positive nodal status, and 1 of them had metastasis. All of them were HER2 negative. All of the 4 patients were positive for ALK ...



CE: Cardiotoxicity and Breast Cancer as Late Effects of Pediatric and Adolescent Hodgkin Lymphoma Treatment

Fri, 25 Mar 2016 12:44:16 +0100

The American Cancer Society estimates that in 2014 nearly 16,000 U.S. children and adolescents developed cancer, and in roughly 1,200 of these cases the cancer was Hodgkin lymphoma (HL). The great majority of these patients will survive, joining the thousands who have been diagnosed and treated successfully in decades past. Nurses’ familiarity with and attention to the late effects of the chemotherapy and radiation therapy used to treat HL, which include breast cancer as well as cardiotoxicity and its sequelae, are essential in helping these patients maintain their overall health. (Source: AJN)






Clinical Characteristics of Primary Vitreoretinal Lymphoma in an Indian Population.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: PVRL in India was likely to be mistaken for an infectious variety of uveitis. A high index of suspicion and thorough clinical examination is necessary to make the diagnosis. PMID: 27003620 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Intraocular T-cell Lymphoma: Clinical Presentation, Diagnosis, Treatment, and Outcome.

Fri, 25 Mar 2016 06:34:02 +0100

CONCLUSIONS: T-cell IOL has variable clinical manifestations and prognosis. Systemic involvement, SRD, and vitreoretinal involvement were frequently observed. PMID: 27002464 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)



Autologous stem cell transplantation in first complete remission may not extend progression free survival in patients with peripheral T cell lymphomas

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion For PTCL patients achieving CR1 following CHOP‐like induction chemotherapy, ASCT does not appear to improve progression free survival compared to active observation. This finding should be confirmed in a larger, prospective study. This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)



Transformation of a previously diagnosed diffuse large B‐cell lymphoma to plasmablastic lymphoma

Thu, 24 Mar 2016 23:00:00 +0100

(Source: American Journal of Hematology)



Ogniskowy rozrost guzkowy wątroby – opis przypadków oraz przegląd literatury

Thu, 24 Mar 2016 23:00:00 +0100

We presented two different cases of focal nodular hyperplasia in children. The first child underwent chemotherapy and bone marrow allotransplantation due to non-Hodgkin lymphoma and focal nodular hyperplasia was diagnosed incidentally a few years later. In the second child, a diagnosis of focal nodular hyperplasia was established in the course of differential diagnosis of abdominal pain. Focal nodular hyperplasia might be difficult to diagnose on the basis of imaging procedures and sometimes liver biopsy is required. (Source: Pediatria Polska)



Expression of Apoptosis‐regulating Proteins Bcl‐2 and Bax in Lymph Node Aspirates from Dogs with Lymphoma

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions and clinical importanceHigher intrinsic resistance to apoptosis following cytotoxic treatment might contribute to the less favorable prognosis associated with multicentric TCL in dogs. Whether Bcl‐2/Bax will be helpful to identify canine BCL and TCL with more aggressive and more indolent behavior, respectively, should be evaluated in larger prospective clinical studies. (Source: Journal of Veterinary Internal Medicine)

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Hypertensive disorders of pregnancy and subsequent risk of solid cancer—A nationwide cohort study

Thu, 24 Mar 2016 23:00:00 +0100

Women with hypertensive disorders of pregnancy (HDP) have higher levels of antiangiogenic growth factors during pregnancy than women with normotensive pregnancies. Since angiogenesis is necessary for solid cancer growth and spread, we hypothesized that women with a history of HDP might have a reduced risk of solid cancers (cancers other than lymphomas, hematologic cancers and nonmelanoma skin cancers) later in life. In a register‐based cohort study of 1.08 million women giving birth at least once between 1978 and 2011, we used Cox regression to estimate hazard ratios (HRs) comparing solid cancer rates for women with and without a history of HDP. In this cohort, 68,236 women (6.3%) had ≥1 pregnancy complicated by HDP and 42,236 women (3.9%) developed solid tumors during follow‐up. A h...



Mast cells in lymphomas

Thu, 24 Mar 2016 23:00:00 +0100

This article is focused on the role of mast cells in lymphoma progression and angiogenesis. Mast cells might be regarded in a future perspective as a new target for the adjuvant treatment of tumors, including lymphomas. (Source: Critical Reviews in Oncology Hematology)



Molecular Cytogenetic Analysis of Chromosome 8 Aberrations in Patients With Multiple Myeloma Examined in 2 Different Stages, at Diagnosis and at Progression/Relapse

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion In the current study, chromosome 8 aberrations were highly heterogeneous, were presented at diagnosis in patients with advanced clinical stage, and were associated with worse overall survival. We have not confirmed the increase of frequency aberration of chromosome 8 in disease progression. The findings demonstrate the importance of fluorescence in situ hybridization examination of chromosome 8 in newly diagnosed patients with MM. Micro-Abstract This retrospective study of 62 patients with multiple myeloma examined at 2 different phases (diagnosis and progression/relapse), revealed chromosome 8 aberrations in 24 (38.7%) patients at diagnosis and in 29 (46.8%) patients at progression/relapse. We did not confirm a significant increase of chromosome 8 aberrations at progression/re...



Induction of apoptosis in human leukemia cells through an intrinsic pathway by cathachunine, a unique alkaloid isolated from Catharanthus roseus

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion: An unprecedented bisindole alkaloid cathachunine which lost C-18′ and C-19′ was isolated from C. roseus. It exerted a potent antitumor effect toward human leukemia cells through the induction of apoptosis via an intrinsic pathway. Thus, this study provides evidence for a new lead compound from a natural source for anti-cancer investigations. Graphical abstract (Source: Phytomedicine)



Dose-adjusted EPOCH chemotherapy with bortezomib and raltegravir for human T-cell leukemia virus-associated adult T-cell leukemia lymphoma

Thu, 24 Mar 2016 23:00:00 +0100

Authors: L Ratner, D Rauch, H Abel, B Caruso, A Noy, S K Barta, S Parekh, J C Ramos, R Ambinder, A Phillips, J Harding, H H Baydoun, X Cheng & S Jacobson (Source: Blood Cancer Journal)

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Personalized Management Approaches in Lymphoma

Thu, 24 Mar 2016 23:00:00 +0100

This article summarizes the most up-to-date literature surrounding the topic of PET/CT-adaptive treatment of different lymphoma subjects. Although more studies are necessary to solidify the role of PET/CT, it is clear that this imaging modality holds much promise for the development of response-adaptive treatment algorithms in the future. (Source: PET Clinics)






Systematic review and meta-analysis of glyphosate exposure and risk of lymphohematopoietic cancers.

Thu, 24 Mar 2016 23:00:00 +0100

Authors: Chang ET, Delzell E Abstract This systematic review and meta-analysis rigorously examines the relationship between glyphosate exposure and risk of lymphohematopoietic cancer (LHC) including NHL, Hodgkin lymphoma (HL), multiple myeloma (MM), and leukemia. Meta-relative risks (meta-RRs) were positive and marginally statistically significant for the association between any versus no use of glyphosate and risk of NHL (meta-RR = 1.3, 95% confidence interval (CI) = 1.0-1.6, based on six studies) and MM (meta-RR = 1.4, 95% CI = 1.0-1.9; four studies). Associations were statistically null for HL (meta-RR = 1.1, 95% CI = 0.7-1.6; two studies), leukemia (meta-RR = 1.0, 95% CI = 0.6-1.5; three studies), and NHL subtypes except B-cell lymphoma (two studies each). Bias and confounding ...



Zarzio ® , biosimilar of filgrastim, in prophylaxis of chemotherapy-induced neutropenia in routine practice: a French prospective multicentric study

Thu, 24 Mar 2016 14:13:52 +0100

Conclusion The results obtained in real-life conditions confirm that Zarzio® is efficient and well tolerated in cancer patients. (Source: Supportive Care in Cancer)



Risk of chemotherapy-induced febrile neutropenia in cancer patients receiving pegfilgrastim prophylaxis: does timing of administration matter?

Thu, 24 Mar 2016 14:13:52 +0100

Conclusions In this large-scale evaluation of adults who received intermediate/high-risk regimens for solid tumors or NHL in US clinical practice, FN incidence was found to be significantly higher among those who received pegfilgrastim prophylaxis on the same day as chemotherapy completion versus days 2–4 from chemotherapy completion, underscoring the importance of adhering to the indicated administration schedule. (Source: Supportive Care in Cancer)

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High-risk follicular dendritic cell sarcoma of the tonsil mimicking nasopharyngeal carcinoma.

Thu, 24 Mar 2016 12:58:02 +0100

Authors: Horváth E, Mocan S, Chira L, Erno E, Turcu M Abstract Follicular dendritic cell sarcoma (FDCS) is often misdiagnosed as a carcinoma or malignant lymphoma due to morphological variability. In FDCS application of routine antibody panels without CD21 and CD23 increases the misdiagnosis rate, because the tumor cells often show focal positivity for usual immunohistochemical markers. Our new case showed a distinct picture due to the uncommon tumor architecture, with extensive areas of necrosis and hemorrhage, the presence of nuclear atypia, and an increased mitotic count and Ki-67 index. These features suggest the classification of this tumor in the category of high-risk malignancies, with uncommon features of FDCSs. PMID: 27003778 [PubMed - in process] (Source: Polish Jou...



First Multicenter, Randomized Phase 3 Study in Patients (Pts) With Relapsed/Refractory (R/R) Peripheral T-Cell Lymphoma (PTCL): Alisertib (MLN8237) Versus Investigator's Choice (LUMIERE trial; NCT01482962).

Thu, 24 Mar 2016 12:15:01 +0100

Authors: PMID: 27007010 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Highlights in Lymphoma From the 2015 ASH Meeting: Commentary.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Chen RW PMID: 27007009 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Updated Efficacy and Safety Data From the AETHERA Trial of Consolidation With Brentuximab Vedotin After Autologous Stem Cell Transplant (ASCT) in Hodgkin Lymphoma Patients at High Risk of Relapse.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: PMID: 27007008 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Randomized Phase 2 Open-Label Study of R-CHOP ± Bortezomib in Patients (Pts) With Untreated Non-Germinal Center B-Cell-like (Non-GCB) Subtype Diffuse Large Cell Lymphoma (DLBCL): Results From the Pyramid Trial (NCT00931918).

Thu, 24 Mar 2016 12:15:01 +0100

Authors: PMID: 27007007 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)

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Brentuximab Vedotin in Combination With Dacarbazine or Bendamustine for Frontline Treatment of Hodgkin Lymphoma in Patients Aged 60 Years and Above: Interim Results of a Multi-Cohort Phase 2 Study.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: PMID: 27007006 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



TARC Predicts PET-Normalization and Event Free Survival in Relapsed/Refractory Hodgkin Lymphoma Patients Treated With Brentuximab Vedotin.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: PMID: 27007005 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Targeted BEACOPP Variants in Patients With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma: Final Analysis of a Randomized Phase II Study.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: PMID: 27007004 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Five-Year Survival Data Demonstrating Durable Responses From a Pivotal Phase 2 Study of Brentuximab Vedotin in Patients With Relapsed or Refractory Hodgkin Lymphoma.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: PMID: 27007002 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)



Combination chemotherapy of solid tumors: an American-Italian collaboration: a celebration of the work of Gianni Bonadonna.

Thu, 24 Mar 2016 12:07:02 +0100

This article highlights the important collaboration between the U.S. NCI in Bethesda, Maryland and the Istituto Tumori in Milan, Italy that had a major impact on the development of curative regimens for breast cancer, Hodgkin's disease and diffuse large B cell lymphoma.In addition to his contribution to developing new therapies, Gianni Bonadonna played an important role in bringing highly focused, disciplined, ethical clinical trials to the European continent. PMID: 27002947 [PubMed - as supplied by publisher] (Source: Tumori)

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Correlation of FcγRIIIa Polymorphisms to the Response of Rituximab in Thai Patients with Diffuse Large B-Cell Lymphoma.

Thu, 24 Mar 2016 11:39:02 +0100

CONCLUSION: The correlation could not be found between FcγRIIIa polymorphisms to the response of rituximab in Thai patients with diffuse large B-cell lymphoma. PMID: 27004307 [PubMed - in process] (Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet)



Loeffler endocarditis in a patient with non-Hodgkin's lymphoma.

Thu, 24 Mar 2016 11:01:02 +0100

Authors: Aguiar Rosa S, Moura Branco L, Galrinho A, Abreu J, Cruz Ferreira R PMID: 27004546 [PubMed - in process] (Source: Kardiologia Polska)



Low dose of lenalidmide and PI3K/mTOR inhibitor trigger synergistic cytoxicity in activated B cell-like subtype of diffuse large B cell lymphoma

Thu, 24 Mar 2016 00:00:00 +0100

Activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL) presents aggressive clinical courses and poor prognosis. Targeting key pathways may raise the possibility of improving clinical outcomes. (Source: Journal of Experimental and Clinical Cancer Research)



PAX5 promotes pre-B cell proliferation by regulating the expression of pre-B cell receptor and its downstream signaling

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: May 2016 Source:Molecular Immunology, Volume 73 Author(s): Kai Xue, Jiazhe Song, Yan Yang, Zhi Li, Chunhua Wu, Jinhua Jin, Wenzhe Li PAX5 is indispensable for the commitment of early lymphoid progenitors to the B cell lineage as well as for the development of B cells. Although previous studies have indicated that the Pax5-conditional-knockout mouse exhibited dedifferentiation of mature B cell and the development of aggressive lymphomas, the changes of Pax5 gene expressions in pre-B cells have not been analyzed. To understand the functional importance of Pax5 gene in the proliferation and survival of pre-B cells, we established a Pax5-knockdown model using 70Z/3 pre-B cell line. Pax5 knockdown 70Z/3 cells (70Z/3-KD cells) showed down-regulations of pre-BCR compoun...



Paediatric non‐Hodgkin lymphoma ‐ perspectives in translational biology

Wed, 23 Mar 2016 23:00:00 +0100

Summary Exciting advances have been achieved for infants, children and adolescents diagnosed with, and treated for, non‐Hodgkin lymphoma (NHL). In spite of these successes, new frontiers are being paved to improve the prognosis for those who relapse or have resistant disease. This review summarizes some of the novel approaches and ideas in NHL monitoring, diagnosis and treatment as discussed at the 5th International Symposium on Childhood, Adolescent and Young Adult Non‐Hodgkin Lymphoma on October 22nd–24th 2015 in Varese, Italy. (Source: British Journal of Haematology)

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A phase II, single‐arm, multicentre study of coltuximab ravtansine (SAR3419) and rituximab in patients with relapsed or refractory diffuse large B‐cell lymphoma

Wed, 23 Mar 2016 23:00:00 +0100

In conclusion, coltuximab ravtansine with rituximab was well tolerated and yielded clinical responses in a subset of patients with relapsed/refractory DLBCL. (Source: British Journal of Haematology)






HELICOBACTER PYLORI CHRONIC GASTRITIS UPDATED SYDNEY GRADING IN RELATION TO ENDOSCOPICAL FINDINGS AND HELICOBACTER PYLORI IgG- ANTIBODY: DIAGNOSTIC METHODS

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 24 March 2016 Source:Journal of Microscopy and Ultrastructure Author(s): Taha MM. Hassan, Samia I Al-Najjar, Ibrahim H. Al-Zahrani, Fadi IB. Alanazi, Malek G Alotibi Helicobacter pylori (Hp) inhabits the stomach of more than 50% of humans and has been established as a major etiologic factor in the pathogenesis of chronic gastritis, gastric atrophy, peptic ulcer disease (PUD), gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma (MALTOMA). The aim of this study is to provide an unequivocal information about the Hp-associated gastritis grading according to the Sydney grading system and to compare between the histopathological features with the endoscopical findings and anti-Hp IgG serological status. This analytical study was...



Rituximab in a patient with splenic marginal zone lymphoma and acquired angioedema

Wed, 23 Mar 2016 23:00:00 +0100

Acquired angioedema (AAE) is a rare disorder with more than 100 cases reported in the literature.1 As initially described by Caldwell et al2 in 1972, two main features characterize AAE: acquired C1 inhibitor (C1-INH) deficiency and hyperactivation of the classic complement pathway. Because C1-INH is responsible for the breakdown of bradykinin, acquired C1-INH deficiency leads to increases in bradykinin, which increase vascular permeability and manifest clinically as recurrent angioedema.3–5 (Source: Annals of Allergy, Asthma and Immunology)



PET-CT: reliable cornerstone for Hodgkin lymphoma treatment?

Wed, 23 Mar 2016 23:00:00 +0100

(Source: Blood)

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PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study

Wed, 23 Mar 2016 23:00:00 +0100

International guidelines recommend that positron emission tomography-computed tomography (PET-CT) should replace CT in Hodgkin lymphoma (HL). The aims of this study were to compare PET-CT with CT for staging and measure agreement between expert and local readers, using a 5-point scale (Deauville criteria), to adapt treatment in a clinical trial: Response-Adapted Therapy in Advanced Hodgkin Lymphoma (RATHL). Patients were staged using clinical assessment, CT, and bone marrow biopsy (RATHL stage). PET-CT was performed at baseline (PET0) and after 2 chemotherapy cycles (PET2) in a response-adapted design. PET-CT was reported centrally by experts at 5 national core laboratories. Local readers optionally scored PET2 scans. The RATHL and PET-CT stages were compared. Agreement among experts and b...



Postibrutinib outcomes in patients with mantle cell lymphoma

Wed, 23 Mar 2016 23:00:00 +0100

Despite unprecedented clinical activity in mantle cell lymphoma (MCL), primary and acquired resistance to ibrutinib is common. The outcomes and ideal management of patients who experience ibrutinib failure are unclear. We performed a retrospective cohort study of all patients with MCL who experienced disease progression while receiving ibrutinib across 15 international sites. Medical records were evaluated for clinical characteristics, pathological and radiological data, and therapies used pre- and postibrutinib. A total of 114 subjects met eligibility criteria. The median number of prior therapies was 3 (range, 0-10). The Mantle Cell Lymphoma International Prognostic Index (MIPI) scores at the start of ibrutinib were low, intermediate, and high in 46%, 31%, and 23% of patients, respective...



UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma

Wed, 23 Mar 2016 23:00:00 +0100

Gene expression profiling has identified 2 major subclasses of diffuse large B-cell lymphoma (DLBCL). Cases resembling germinal center (GC) B cells (GCB-DLBCL) generally occur in younger patients, have a distinct molecular pathophysiology, and have improved outcomes compared with those similar to activated post-GC cells (activated B-cell DLBCL). We previously found that the ubiquitin hydrolase UCH-L1 is frequently overexpressed in mature B-cell malignancies and is a potent oncogene in mice. The cause for its overexpression in lymphoma, and whether it impacts the outcome of patients with DLBCL is unknown. Here, we show that UCH-L1 reflects GC lineage in lymphoma and is an oncogenic biomarker of aggressive GCB-DLBCL. We find that UCH-L1 is specifically induced in GC B cells in mice and human...



Radiation Therapy for Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL): An International Lymphoma Radiation Oncology Group (ILROG) Multi-institutional Experience

Wed, 23 Mar 2016 23:00:00 +0100

pcALCL is radiosensitive tumor with 95% CCR. Most ILROG members used doses in the range of 30-39 Gy. However, lower doses also appear effective, regardless of T stage. (Source: International Journal of Radiation Oncology * Biology * Physics)



Rituximab in a patient with splenic marginal zone lymphoma and acquired angioedema.

Wed, 23 Mar 2016 23:00:00 +0100

Authors: Motosue MS, Howard MT, Butterfield JH PMID: 27017557 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)

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Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-κB.

Wed, 23 Mar 2016 14:45:02 +0100

In conclusion, these results suggest that TSA induces cell death and chemosensitizes colon cancer cells through the suppression of NF-κB signaling. PMID: 26998041 [PubMed - as supplied by publisher] (Source: Experimental and Therapeutic Medicine)



Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell non-Hodgkin's lymphoma.

Wed, 23 Mar 2016 14:45:02 +0100

In conclusion, miR-503 was highly expressed, whereas KAI1 was poorly expressed, in the tissues and peripheral blood of B-NHL patients. Thus, miR-503 may have an application as a novel therapeutic and diagnostic marker in B-NHL patients. PMID: 26998012 [PubMed - as supplied by publisher] (Source: Experimental and Therapeutic Medicine)



Development of epstein–barr virus uveitis after remission of primary vitreoretinal lymphoma

Wed, 23 Mar 2016 04:26:49 +0100

Conclusion: The authors describe a rare case of EBV uveitis that was preceded by PVRL. It is important to consider EBV in cases where suspected recurrence of PVRL does not respond to appropriate treatment. (Source: Retinal Cases and Brief Reports)



Outcome of children and adolescents with lymphoblastic lymphoma

Wed, 23 Mar 2016 03:16:17 +0100

Conclusion: our findings confirm the favorable prognosis of children with LBL with an intensive chemotherapy regimen derived from ALL therapy.RESUMO Objetivos: linfoma linfoblástico (LL) é o segundo subtipo mais comum de linfoma não Hodgkin em crianças. O objetivo deste estudo foi caracterizar a evolução clínica de crianças e adolescentes com LL em um centro terciário. Métodos: estudo de coorte retrospectivo de 27 pacientes com idade de até 16 anos com LL admitidos entre janeiro de 1981 e dezembro de 2013. Os pacientes foram tratados de acordo com o protocolo de tratamento para leucemia linfoblástica aguda (LLA). O diagnóstico foi baseado em biópsia do tumor e/ou no exame citológico de derrame pleural. A sobrevida global foi analisada pelo método de Kaplan-Meier. Resultados...



The Effects of Arsenic Trioxide in Combination with Retinoic Acids on Cutaneous T-Cell Lymphoma Cell Lines

Wed, 23 Mar 2016 01:22:59 +0100

Cutaneous T-cell lymphomas (CTCL) are characterized by an infiltration of the skin with malignant T cells. Curative treatments for aggressive entities such as Sézary syndrome have not been identified yet. Arsenic trioxide (AsO3) is used for the treatment of acute promyelocytic leukemia in combination with retinoids. As the latter are established treatment options in CTCL, we sought to evaluate the efficacy of AsO3 for mono- and combination therapy in vitro. Analyses for apoptosis, cell cycle inhibition, cytotoxicity and cell viability were made after incubation of CTCL cells with AsO3 alone or in combination with the retinoids all-trans-retinoic acid or bexarotene. While AsO3 induced apoptosis, retinoids did not at the time point of analysis. However, retinoids strongly reduced cell viabi...

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Survival Outcomes of Primary Intraocular Lymphoma: A Single-institution Experience

Wed, 23 Mar 2016 00:15:31 +0100

Conclusions: In this series of patients with PIOL+/− CNS disease, CNS and intraocular relapse were common. A trend toward better survival was seen among patients with isolated ocular presentation, and a limited number of long-term disease-free survivors seen after CMT. (Source: American Journal of Clinical Oncology)



Breast Imaging in Women Previously Irradiated for Hodgkin Lymphoma

Wed, 23 Mar 2016 00:15:31 +0100

Conclusions: The role of screening breast MRI in women previously irradiated for HL is evolving. Further education of patients and physicians is important to increase awareness of more sensitive BC screening modalities in this high-risk population. Future studies are necessary to determine the appropriate integration of screening breast MRI into the ongoing follow-up of these women. (Source: American Journal of Clinical Oncology)



APO866 Efficacy and Safety in Refractory Cutaneous T-Cell Lymphoma

Wed, 23 Mar 2016 00:00:00 +0100

This phase 2 clinical trial assesses the efficacy and safety of APO866 in patients with refractory or relapsed cutaneous T-cell lymphoma. (Source: JAMA Dermatology)



Development of ZMYM2‐FGFR1 driven AML in human CD34+ cells in immunocompromised mice

Tue, 22 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



Methotrexate-related lymphoproliferative disorder of the oral region in patients with rheumatoid arthritis

Tue, 22 Mar 2016 23:00:00 +0100

Conclusions The occurrence of MTX-related oral LPDs showed a predilection for gingiva with frequent characteristics of ulceration, pain and bone exposure. Almost all cases were EBV-positive. (Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology)

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Rare Occurrence of 3 “H”: Hypercalcemia, Hemolytic Anemia and Hodgkin’s Lymphoma

Tue, 22 Mar 2016 23:00:00 +0100

We report a 71-years old lady who presented to our hematology clinic with fever and easy fatiguability of 3 months duration and on investigations was found to have anemia and hypercalcemia. Direct Coomb’s test characterized the anemia as complement mediated (anti-C3d) hemolysis. Biochemical investigations revealed normal 25(OH) Vitamin D3 and suppressed Parathormone levels and a negative workup for plasma cell dyscrasias, sarcoidosis and autoimmune disorders. CT scan revealed a paravertebral mass with cervical, supraclavicular and abdominal lymphadenopathy along with splenomegaly and left pleural effusion. Biopsy from the paravertebral mass confirmed the diagnosis of Hodgkin’s disease (nodular sclerosis) using immunohistochemistry. Bone marrow examination suggested infiltration by lym...



Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes

Tue, 22 Mar 2016 23:00:00 +0100

Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the ...






Bispecific T-Cell Engager (BiTE) Antibody Construct Blinatumomab for the Treatment of Patients With Relapsed/Refractory Non-Hodgkin Lymphoma: Final Results From a Phase I Study [Hematologic Malignancy]

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion In this phase I study of relapsed/refractory NHL, continuous infusion with CD19-targeted immunotherapy blinatumomab at various doses and schedules was feasible, with an MTD of 60 μg/m2/day. Single-agent blinatumomab showed antilymphoma activity. (Source: Journal of Clinical Oncology)



Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease [Hematologic Malignancy]

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion Allogeneic anti-CD19 CAR T cells can effectively treat B-cell malignancies that progress after alloHSCT. The findings point toward a future when antigen-specific T-cell therapies will play a central role in alloHSCT. (Source: Journal of Clinical Oncology)

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Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community-Based Retrospective Cohort Study [Epidemiology]

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion The magnitude of subsequent CVD risk varies according to cancer subtype and by the presence of CVRFs. Overall survival in survivors who develop CVD is poor, emphasizing the need for targeted prevention strategies for individuals at highest risk of developing CVD. (Source: Journal of Clinical Oncology)



Bispecific T-Cell Engagers (BiTEs) as Treatment of B-Cell Lymphoma [UNDERSTANDING THE PATHWAY]

Tue, 22 Mar 2016 23:00:00 +0100

(Source: Journal of Clinical Oncology)



Clinicopathological analysis of a case series of peripheral T-cell lymphomas, not otherwise specified, of lymphoepithelioid variant (Lennert's lymphoma). A Central European single-center study—reply

Tue, 22 Mar 2016 23:00:00 +0100

We reported a case series of nodal EBV+ T/NK-cell lymphomas that were characterized by diffuse proliferation of atypical cells centroblastic in terms of morphology that expressed cytotoxic molecules, which were frequently of the CD8+αβT-cell lineage that exhibited predominantly nodal involvement of elderly patients, and that were very aggressive in terms of clinical behavior [1]. Thus, we proposed that EBV+ nodal T/NK-cell lymphoma might represent a distinctive clinicopathological entity of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). (Source: Human Pathology)



Clinicopathological analysis of a case series of peripheral T-cell lymphomas, not otherwise specified, of lymphoepithelioid variant (Lennert’s lymphoma). A Central European single-center study

Tue, 22 Mar 2016 23:00:00 +0100

We have read with great interest the paper of Jeon et al. [1], representing the Hematopathology Study Group of the Korean Society of Pathologists, in which they published a case series of 15 patients with Epstein-Barr virus–positive (EBV+) nodal T/NK-cell lymphoma. The International Prognostic Index (IPI) was high or high/intermediate in 87% of patients; 67% of the patients showed CD8 positivity, with 2 of them being CD4CD8 double positive. For the rest, some were CD4 positive (n = 2) or CD4CD8 double negative (n = 3). (Source: Human Pathology)