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Preview: MedWorm: Cancer of the Uterus

MedWorm: Cancer of the Uterus provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Cancer of the Uterus category.

Last Build Date: Tue, 29 Mar 2016 14:36:20 +0100


A SNaPshot of potentially personalized care: Molecular diagnostics in gynecologic cancer.

Mon, 28 Mar 2016 20:57:02 +0100

CONCLUSION: Although SNaPshot can identify potentially important therapeutic targets, the incidence of 'drugable' targets in ovarian cancer is low. In this cohort, only 7% of subjects eventually were treated on a relevant clinical trial. Geneotyping should be used judiciously and reflect histologic subtype and available platform. PMID: 27016236 [PubMed - in process] (Source: Gynecologic Oncology)

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Germline mutations of the DNA repair pathways in uterine serous carcinoma.

Mon, 28 Mar 2016 20:57:02 +0100

CONCLUSIONS: A significant proportion of our cohort harbor germline mutations in DNA repair genes. This may be associated with the high rate of breast cancer in our patients and their family, and suggests a targeted cohort for genetic counseling. If validated in a larger cohort, our findings may allow clinicians to expand therapeutic options to include targeted therapies and inclusion of USC patient in preventative and genetic counseling. PMID: 27016235 [PubMed - in process] (Source: Gynecologic Oncology)

Initiation of a formalized precision medicine program in gynecologic oncology.

Mon, 28 Mar 2016 20:57:02 +0100

CONCLUSIONS: The predominant function of our PMB is establishment of a forum to enhance research while providing clinical care for refractory malignancies. We have matched patients with specific mutations to ongoing trials and are developing investigator-initiated studies based on trends within genomic profiling results. Longer-term follow up will be required to determine the success of this strategy. PMID: 27016225 [PubMed - in process] (Source: Gynecologic Oncology)

Treatment of Uterine Carcinomas

Mon, 28 Mar 2016 12:30:44 +0100

Uterine epithelial cancers are the most common type of gynecologic cancer in the United States. The American Cancer Society estimated 53,000 new cases of uterine cancers in 2014 with 8,600 deaths from advanced or recurrent cases, 99% of which are endometrial cancer. The 5-year survival rate of low-stage, low-grade endometrioid adenocarcinoma is greater than 90%. In contrast, advanced stage endometrioid adenocarcinomas and Type II (serous and carcinosarcoma) endometrial cancers have a much poorer prognosis, with the 5-year survival rate of advanced stage uterine carcinosarcoma as low as 9%. Together, these endometrial cancers with poor prognoses comprise almost half of all cases in the US, creating a significant medical obstacle for management. The authors present a review of endometrial ca...

Current Strategies and Future Directions in Classification and Treatment of Uterine Sarcomas

Mon, 28 Mar 2016 12:30:44 +0100

Uterine sarcomas comprise endometrial stroma tumors (EST) and uterine leiomyosarcomas (ULMS), with ESTs accounting for less than 2% and ULMS accounting for approximately 1% of uterine neoplasms. Recent classifications of ESTs denote as many as four categories: benign endometrial stromal nodule (ESN), low-grade endometrial stromal sarcomas (ESS), high-grade endometrial stromal sarcomas (HGESS), and undifferentiated uterine sarcomas (UUS). The designation UUS has been suggested to encompass undifferentiated endometrial sarcomas (UES) and undifferentiated uterine sarcomas of other tissue origins. The prognosis for ESS is good. Although a third of cases recur, the 5-year survival rate for Stage I disease can be as high as 98%. In contrast the prognosis for UES is poor, with a 5-year survival r...

Accuracy of preoperative endometrial sampling diagnosis for predicting the final pathology grading in uterine endometrioid carcinoma

Fri, 25 Mar 2016 23:00:00 +0100

Conclusions Preoperative endometrial sampling was found to be only a modest overall predictor of postoperative histological grading. A selective staging policy based on predictive models to avoid lymph node dissections in endometrial cancer should take into account additional parameters. (Source: European Journal of Surgical Oncology (EJSO))

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The value of magnetic resonance imaging in investigating complex atypical hyperplasia of the endometrium.

Fri, 25 Mar 2016 05:38:02 +0100

CONCLUSION: In our series, we found that MRI had no value in the management of CAH. Thirty-three endometrioid endometrial cancers (31%) were identified and we found no high-risk subtypes, and simple hysterectomy and bilateral salpingo-oophorectomy would be performed and the few stage 2 cases diagnosed were microscopic and would not have been diagnosed on MRI. PMID: 27002383 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)

Biologic Disease‐Modifying Antirheumatic Drugs and Risk of High‐grade Cervical Dysplasia and Cervical Cancer in Rheumatoid Arthritis: A Cohort Study

Thu, 24 Mar 2016 23:00:00 +0100

Conclusion: Among women with RA, initiation of biologic DMARDs was associated with a numerically, but not statistically significant, increase in the risk of high‐grade cervical dysplasia or cervical cancer versus non‐biologics. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)

Telocytes in the reproductive organs: current understanding and future challenges

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: Available online 25 March 2016 Source:Seminars in Cell & Developmental Biology Author(s): Dragos Cretoiu, Sanda Maria Cretoiu Over the past decades, we were witnessing spectacular molecular medicine advances. However, many of the reproductive medicine problems, such as fertility issues and premature birth still represent major challenges for obstetrics & gynecology worldwide. A new cell population − the telocytes (TCs) − were described in the interstitial space of many organs, and their possible implications in many important physiological and pathological processes should not be overlooked. In this article, we present a historical perspective outlining the landmarks in the discovery, evolution and achievements in the field of TCs over the last ten...

Primary HPV testing: a proposal for co‐testing in initial rounds of screening to optimise sensitivity of cervical cancer screening

Wed, 23 Mar 2016 23:34:13 +0100

This article proposes a compromise: cytology and HPV co‐testing for the first two screening tests to optimise the sensitivity of the test as a whole. Registrations of invasive and in situ carcinoma of the uterine cervix in England indicate that the prevalence of the disease is highest in young women in the early rounds of screening. Calculations of the likely impact on the workload of this proposal have been based on a service evaluation of 295 cytology tests received at St Thomas’ Hospital, which suggests that the volume of cytology tests would be reduced by approximately 60% compared with 80% for primary HPV testing alone. This proposal should be debated openly before irrevocable changes are made to a skilled workforce. (Source: Cytopathology)

Phase I dose escalation study of temsirolimus in combination with metformin in patients with advanced/refractory cancers

Wed, 23 Mar 2016 23:00:00 +0100

Conclusions Combination temsirolimus/metformin was well tolerated with modestly promising effectiveness among this heavily pretreated patient cohort. We recommend a dose of temsirolimus 25 mg weekly and metformin 2000 mg daily for phase II study. (Source: Cancer Chemotherapy and Pharmacology)

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The prognostic value of rectal invasion for stage IVA uterine cervical cancer treated with radiation therapy

Wed, 23 Mar 2016 00:00:00 +0100

The objective of this study is to evaluate patient outcome and prognostic factors in stage IVA cervical cancer treated wit... (Source: BMC Cancer)

Comparative Effectiveness of Minimally Invasive Hysterectomy for Endometrial Cancer [Gynecologic Cancer]

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion Minimally invasive hysterectomy does not appear to compromise long-term survival for women with endometrial cancer. (Source: Journal of Clinical Oncology)

Cancer Incidence Among Adolescents and Young Adults (15 to 29 Years) in Brazil

Tue, 22 Mar 2016 07:43:43 +0100

This study describes, for the first time, the cancer incidence rate in AYAs in Brazil, and we believe that our findings represent the Brazilian profile. (Source: Journal of Pediatric Hematology Oncology)

Id: 38: primary squamos cell carcinoma of the rectum

Mon, 21 Mar 2016 23:00:00 +0100

In conclusion, SCC of rectum is a distinct entity and it is important to shed some light on this rare condition because it has different epidemiology, etiology, pathogenies and requires a different treatment approach than other colorectal carcinomas. Surgery is the primary treatment which consists of local excision versus radical resection and the need for adjuvant therapy. Abstract ID: 38 Figure 1 (Source: Journal of Investigative Medicine)

Id: 50: perforated diverticulosis complicated with actinomycosis infection and presented as pelvic malignancy

Mon, 21 Mar 2016 23:00:00 +0100

Discussion Actinomycosis is a rare and insidious disease. The most common etiologic organism is the anaerobic, Gram-positive bacterium, Actinomyces israelii. Actinomycetes are prominent among the normal flora of the oral cavity but less prominent in the lower gastrointestinal and female genital tract. Because these microorganisms are not virulent, they require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures and to cause human illness. Cervicofacial actinomycosis is the most common type of the infections followed by Thoracic actinomycosis and less common in abdomen and pelvis. The most common cause of abdominal/pelvic actinomycosis is acute perforated appendicitis. Also, most of Abdomen/Pelvis cases have a history of r...

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Laparoscopic treatment of early-stage endometrial cancer with and without uterine manipulator: our experience and review of literature

Mon, 21 Mar 2016 23:00:00 +0100

The aim of this study was to retrospectively compare in a series of 110 patients with early-stage endometrial cancer recurrence rate and surgical outcomes after total laparoscopic (LPS) hysterectomy with lymphadenectomy performed with or without uterine manipulator. (Source: Surgical Oncology) +5 | The top 5 medtech stories for March 21, 2016

Mon, 21 Mar 2016 20:00:34 +0100

Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. Senate bill would streamline FDA’s medical device reviews A bipartisan duo in the U.S. Senate introduced a bill last week that aims to streamline the way the FDA reviews medical devices. Sens. Amy Klobuchar (D-Minn.) and Pat Roberts (R-Kan.) introduced S.2737, or “A bill to improve medical device innovation,” to the Upper Chamber’s Health, Education, Labor & Pensions ...

Johnson & Johnson looks to settle morcellator lawsuits

Mon, 21 Mar 2016 10:05:47 +0100

Johnson & Johnson(NYSE:JNJ) is reportedly looking to settle 100s of product liability and wrongful death lawsuits brought over its now-recalled laparoscopic power morcellators used during surgeries to remove ostensibly benign uterine tumors. The morcellators, which use a cutting tip to shred and remove uterine tissue, have been implicated in the spread of a lethal cancer that can masquerade undetected as benign fibroids. The FDA in April 2014 issued a warning about the devices, later convening a special advisory panel to evaluate their continued use in the surgical suite. The watchdog agency estimates that about 0.3% of women undergoing hysterectomy or fibroid surgery are found to have undetected uterine sarcomas, including the deadly leiomyosarcoma. In November of that year, the ...

Outcome of uterine sarcoma patients treated with pazopanib: A retrospective analysis based on two European Organisation for Research and Treatment of Cancer (EORTC) Soft Tissue and Bone Sarcoma Group (STBSG) clinical trials 62043 and 62072.

Sun, 20 Mar 2016 23:00:00 +0100

CONCLUSIONS: Despite heavy pre-treatment, pazopanib shows signs of activity in patients with uterine sarcoma with the similar outcomes to patients with non-uterine STS. PMID: 27012429 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Investigational drug for ovarian, uterine tumors shows promise

Sat, 19 Mar 2016 19:21:43 +0100

SAN DIEGO – A novel dual AKT and P70S6K inhibitor decreased tumor growth metastases in multiple animal models of ovarian and uterine cancer, results from a novel study demonstrated. It also prolonged... (Source: Ob.Gyn. News)

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Abnormal expression of leiomyoma cytoskeletal proteins involved in cell migration.

Sat, 19 Mar 2016 17:53:03 +0100

Authors: Ura B, Scrimin F, Arrigoni G, Athanasakis E, Aloisio M, Monasta L, Ricci G Abstract Uterine leiomyomas are monoclonal tumors. Several factors are involved in the neoplastic transformation of the myometrium. In our study we focused on dysregulated cytoskeletal proteins in the leiomyoma as compared to the myometrium. Paired tissue samples of ten leiomyomas and adjacent myometria were obtained and analyzed by two‑dimensional gel electrophoresis (2-DE). Mass spectrometry was used for protein identification, and western blotting for 2-DE data validation. The values of ten cytoskeletal proteins were found to be significantly different: eight proteins were upregulated in the leiomyoma and two proteins were downregulated. Three of the upregulated proteins (myosin regulatory ligh...

Expression of MIF and c-erbB-2 in endometrial cancer.

Sat, 19 Mar 2016 16:30:04 +0100

Authors: Xiao W, Dong X, Zhao H, Han S, Nie R, Zhang X, An R Abstract The aim of the present study was to investigate the expression of c-erbB-2 and macrophage migration inhibitory factor (MIF) in endometrial cancer and to elucidate the significance of the early diagnosis and prognosis of endometrial cancer. The gene copy number of c‑erbB‑2 and MIF was characterized by reverse transcription quantitative polymerase chain reaction and the reactivity was assessed by immunohistochemistry in 70 patients using a polyclonal antibody, and evaluated semiquantitatively according to the percentage of cells demonstrating membranous or diffuse cytoplasmic staining. A correlation between age, tumor stage, grade, myometrial invasion and lymph node metastasis was observed. The mRNA expression...

European cancer mortality predictions for the year 2016 with focus on leukaemias

Sat, 19 Mar 2016 00:00:00 +0100

Conclusion The 2016 predictions for EU cancer mortality confirm the favourable trends in rates particularly for men. Lung cancer is likely to be the leading site for female cancer rates. Continuing falls in mortality, larger in children and young adults, are predicted in leukaemias, essentially due to advancements in management and therapy, and their subsequent adoption across Europe. (Source: Annals of Oncology)

Naringenin-Induced Migration of Embrynoic Trophectoderm Cells is Mediated via PI3K/AKT and ERK1/2 MAPK Signaling Cascades

Fri, 18 Mar 2016 00:00:00 +0100

Publication date: Available online 17 March 2016 Source:Molecular and Cellular Endocrinology Author(s): Whasun Lim, Gwonhwa Song For successful pregnancy, a well-coordinated network of growth factors, nutrients and hormones is required for fetal-maternal interactions. Naringenin, as a weak phytoestrogen, improves diabetes, inflammation, neuronal diseases, cardiovascular diseases and cancers. However, the role of naringenin in migration mechanism(s) of peri-implantation conceptuses is unknown. Therefore, in the present study, we determined the effects of naringenin on migration of porcine trophectoderm (pTr) cells, which is a known in vitro model for research on trophectoderm cell biology and placental-fetal developmental biology, in order to assess intracellular signal transduction pat...

Understanding the Pathogenicity of Noncoding Mismatch Repair Gene Promoter Variants in Lynch Syndrome

Fri, 18 Mar 2016 00:00:00 +0100

In conclusion, we propose a guide that could be integrated into the current InSiGHT classification scheme to help determine if a MMR gene promoter variant is pathogenic. (Source: Human Mutation)

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The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors.

Thu, 17 Mar 2016 23:00:00 +0100

CONCLUSIONS: Together, our studies define a novel HMGA1-MMP-2 pathway involved in a subset of human carcinosarcomas and tumor progression in murine models. Our work also suggests that targeting HMGA1 could be effective adjuvant therapy for more aggressive uterine cancers and provides compelling data for further preclinical studies. PMID: 27001612 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Cervical cancer stem cells selectively overexpress HPV oncoprotein E6 that controls stemness and self renewal through upregulation of HES1.

Thu, 17 Mar 2016 00:00:00 +0100

CONCLUSIONS: Our findings suggest the possible mechanism by which HPVE6 potentially regulate and maintain stem-like cancer cells through Hes1. PMID: 26988248 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Uterine perforation of pyometra in a cervical cancer: A case report and literature review.

Wed, 16 Mar 2016 15:40:01 +0100

Authors: Konishi Y, Kagabu S, Mori K, Kato M PMID: 26977976 [PubMed - as supplied by publisher] (Source: Journal of Obstetrics and Gynaecology)

Elevated phosphatase of regenerating liver 3 (PRL-3) promotes cytoskeleton reorganization, cell migration and invasion in endometrial stromal cells from endometrioma

Tue, 15 Mar 2016 00:00:00 +0100

STUDY QUESTION Is phosphatase of regenerating liver-3 (PRL-3) associated with increased motility of endometriotic cells from endometrioma? SUMMARY ANSWER Elevated PRL-3 promotes cytoskeleton reorganization, cell migration and invasion of endometrial stromal cells (ESCs) from endometrioma. WHAT IS KNOWN ALREADY Overexpression of PRL-3 is associated with cancer cell migration, invasion and metastatic phenotype. STUDY DESIGN, SIZE, DURATION Primary human ESCs were isolated from eutopic endometrium of women without endometriosis (EuCo, n = 10), with histologically proven endometrioma (EuEM, n = 19) and from the cyst wall of ovarian endometriosis (OvEM, n = 26). PARTICIPANTS/MATERIALS, SETTING, METHODS The expression of PRL-3 in ESCs derived from EuCo, EuEM and OvEM at different phases of m...

Endometrial (Uterine) Cancer: What You Need to Know.

Tue, 15 Mar 2016 00:00:00 +0100

Authors: PMID: 26977844 [PubMed - as supplied by publisher] (Source: American Family Physician)

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Diagnosis and Management of Endometrial Cancer.

Tue, 15 Mar 2016 00:00:00 +0100

Authors: Braun MM, Overbeek-Wager EA, Grumbo RJ Abstract Endometrial cancer is the most common gynecologic malignancy. It is the fourth most common cancer in women in the United States after breast, lung, and colorectal cancers. Risk factors are related to excessive unopposed exposure of the endometrium to estrogen, including unopposed estrogen therapy, early menarche, late menopause, tamoxifen therapy, nulliparity, infertility or failure to ovulate, and polycystic ovary syndrome. Additional risk factors are increasing age, obesity, hypertension, diabetes mellitus, and hereditary nonpolyposis colorectal cancer. The most common presentation for endometrial cancer is postmenopausal bleeding. The American Cancer Society recommends that all women older than 65 years be informed of the ...

Androgen receptors are acquired by healthy postmenopausal endometrial epithelium and their subsequent loss in endometrial cancer is associated with poor survival

Tue, 15 Mar 2016 00:00:00 +0100

Authors: A M Kamal, J N Bulmer, S B DeCruze, H F Stringfellow, P Martin-Hirsch & D K Hapangama (Source: British Journal of Cancer)

John Grisham book turns spotlight on futuristic cancer treatment

Mon, 14 Mar 2016 21:16:57 +0100

(Reuters) – A new book by bestselling author John Grisham is giving new impetus to a handful of companies striving to develop what they say could be a trailblazing treatment for cancer and Alzheimer’s disease. “The Tumor” is a fictional account of a 35-year-old man with brain cancer who, a decade into the future, is treated with focused ultrasound – a real-life technology that is currently being researched as a potential cure for more than 50 diseases. Focused ultrasound uses soundwaves to destroy damaged tissue deep within the body, doing away with the need for incisions or radiation therapy. It has been approved in the United States as a treatment for several conditions, including prostate cancer. As a treatment for brain and other cancers, it remains a futurist...

Macrophages Increase Estrogen Sensitivity in EC

Mon, 14 Mar 2016 00:00:00 +0100

In this study, we investigated the association between infiltrating macrophages and estrogen sensitivity in endometrial cancer. Evaluating tissue samples and serum from patients with precancerous lesions or endometrial cancer, we found that tissue macrophage infiltration, but not serum estradiol levels, correlated positively with endometrial cancer development. Furthermore, IL4/IL13-induced CD68+CD163+ macrophages enhanced the proliferative effects of estradiol in endometrial cancer cells by upregulating estrogen receptor alpha (ERα), but not ERβ. Mechanistic investigations revealed that CD68+CD163+ macrophages secreted cytokines, such as IL17A, that upregulated ERα expression through TET1-mediated epigenetic modulation of the ERα gene. Overall, our findings show how cytokines produced...

Endocervical metastasis of pancreatic cancer: A rare case report of long-term survival

Sat, 12 Mar 2016 00:00:00 +0100

Publication date: September 2016 Source:Human Pathology: Case Reports, Volume 5 Author(s): Yuichi Kinoshita, Katsuhiko Yoshizawa, Takashi Yuri, Airo Tsubur, Nobuaki Shikata Most uterine cervix adenocarcinomas are primary tumors. Here, we report a case of pancreatic cancer that metastasized to the uterine cervix. The patient was a 77-year-old Jehovah's Witness whose pancreatic cancer had been diagnosed 10years previously. As she had refused blood transfusion on religious grounds, the tumor only underwent segmental excision, followed by radiofrequency wave therapy and chemotherapy. During a routine health examination 6years after her pancreatic tumor resection, a tumor in the left lower lobe of her lung was found, and then removed. Three years after the lung surgery, her serum CA19-9 ...

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Characterizing gradient echo signal decays in gynecologic cancers at 3T using a Gaussian augmentation of the monoexponential (GAME) model

Sat, 12 Mar 2016 00:00:00 +0100

Conclusion may prove sensitive to hypoxia; however, inaccurate representations of underlying data may limit the success of quantitative assessments. Although the degree to which R2 or σ values correlate with hypoxia remains unknown, improved characterization with GAME increases the potential for determining any correlates of fit parameters with biomarkers, such as oxygenation status. J. Magn. Reson. Imaging 2016. (Source: Journal of Magnetic Resonance Imaging)

Synchronous uterine adenocarcinoma and leiomyosarcoma: A rare case report causing a clinical conundrum

Sat, 12 Mar 2016 00:00:00 +0100

Conclusion Simultaneous uterine adenocarcinoma and leiomyosarcoma is an exceptionally rare event. As the experience is limited, a multidisciplinary approach in managing these patients may be the best option currently available. (Source: International Journal of Surgery Case Reports)

Annual Report to the Nation: Cancer Death Rates Still Dropping

Fri, 11 Mar 2016 01:22:35 +0100

By Stacy Simon The death rate from cancer in the United States is continuing the decline that began in the early 1990s, according to the latest Annual Report to the Nation on the Status of Cancer. It shows the rate of death from cancer in the United States is going down among both men and women, for children, and for the most common types of cancer, including lung, colon, breast, and prostate. However, the report identified some cancer types with increasing incidence or death rates, including liver cancer. The American Cancer Society, the North American Association of Central Cancer Registries, the Centers for Disease Control and Prevention, and the National Cancer Institute work together to create the report, which has been published each year since 1998. It provides an update of new canc...

Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1.

Thu, 10 Mar 2016 18:18:02 +0100

Authors: Mints M, Mushtaq M, Iurchenko N, Kovalevska L, Stip MC, Budnikova D, Andersson S, Polischuk L, Buchynska L, Kashuba E Abstract Endometrial cancer (EC) is one of the most frequent causes of cancer death among women in developed countries. Histopathological diagnosis and imaging techniques for EC are limited, thus new prognostic markers are needed to offer patients the best treatment and follow-up.In the present paper we showed that the level of mitochondrial ribosomal protein MRPS18-2 (S18-2) increased in EC compared with the normal endometrium and hyperplasia, based on a study of 42 patient biopsies. Importantly, high expression of free E2F1 in EC correlates well with high S18-2 expression. The EC cell line HEC-1-A, which overexpresses S18-2 constitutively, showed an incre...

Hyperhaploid uterine mesenchymal tumors – a novel genetic subgroup?

Thu, 10 Mar 2016 00:00:00 +0100

In this report, we describe hyperhaploidy in a case of an endometrial stromal nodule of a 50 year old woman who underwent hysterectomy because of symptomatic uterine fibroids. In addition, we review two other recently described cases of uterine mesenchymal tumors with that type of genetic alteration. Despite some histologic differences, striking similarities between these three cases exist with respect to the chromosomes were retained as disomic. Thus, the question arises if hyperhaploidy defines a novel genetic subgroup of uterine mesenchymal tumors. (Source: Cancer Genetics)

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Discrepancy between clinicoradiological and surgicopathological staging in stage 1 carcinoma endometrium: Identification of risk factors

Thu, 10 Mar 2016 00:00:00 +0100

CONCLUSION: Significant upstaging is seen in the present study with per-operative staging procedures. Until the standardization of magnetic resonance imaging (MRI) techniques and reporting, or until a more sensitive non-invasive technique is devised, staging lymphadenectomy appears to be invaluable in risk assessment and prognosis. (Source: Indian Journal of Cancer)

Bizarre leiomyoma of uterus/smooth muscle tumor of uncertain malignant potential: A diagnostic dilemma

Thu, 10 Mar 2016 00:00:00 +0100

SY Swami, RD Ganjewar, S Gaikwad, DD GirjiIndian Journal of Cancer 2015 52(4):697-698 (Source: Indian Journal of Cancer)

Diet and exercise in uterine cancer survivors (DEUS pilot) - piloting a healthy eating and physical activity program: study protocol for a randomized controlled trial

Thu, 10 Mar 2016 00:00:00 +0100

Endometrial cancer survivors comprise a high-risk group for obesity-related comorbidities. Healthy eating and physical activity can lead to better health and well-being, but this population may experience diff... (Source: Trials)

Transarterial embolization of hypervascular tumors using trisacryl gelatin microspheres (Embosphere): a prospective multicenter clinical trial in Japan

Thu, 10 Mar 2016 00:00:00 +0100

Conclusion TAE using TGMs was technically feasible and safe for devascularization of hypervascular tumors. (Source: Japanese Journal of Radiology)

Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice.

Wed, 09 Mar 2016 00:00:00 +0100

Authors: Wang X, Khatri S, Broaddus R, Wang Z, Hawkins SM Abstract Women with endometriosis can suffer from decreased fecundity or complete infertility via abnormal oocyte function or impaired placental-uterine interactions required for normal pregnancy establishment and maintenance. Although AT-rich interactive domain 1A (SWI-like) (ARID1A) is a putative tumor suppressor in human endometrial cancers and endometriosis-associated ovarian cancers, little is known about its role in normal uterine function. To study the potential function of ARID1A in the female reproductive tract, we generated mice with a conditional knockout of Arid1a using anti-Müllerian hormone receptor 2-Cre. Female Arid1a conditional knockout mice exhibited a progressive decrease in number of pups per litter, wi...

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Gafchromic film dosimetry of a new HDR 192Ir brachytherapy source

Tue, 08 Mar 2016 08:00:00 +0100

High-dose-rate (HDR) brachytherapy is a popular modality for treating cancers of the prostate, cervix, endometrium, breast, skin, bronchus, esophagus, and head and neck as well as soft-tissue sarcomas. Because of different source designs and licensing issues, there is a need for specific dosimetry dataset for each HDR source model. The main objective of the present work is to measure 2D relative dose distribution around a new prototype 192Ir source, referred to as IRAsource-HDR, in PMMA phantom in the framework of AAPM TG-43 and TG-55 recommendations for radial distances of 0.5cm to 4 cm. Radiochromic films (RCFs) Gafchromic EBT and HD-810 were used for measurements. The dose rate constant, Λ, of the source was determined to be 1.084± 4.6%, 1.129 ± 4.4%, and 1.112 ± 0.8% cGyh-1U-1 usin...

Genetic variability within Adenosine Deaminase gene and uterine leiomyomas

Tue, 08 Mar 2016 00:00:00 +0100

Conclusions This pattern is identical to that previously observed in colon cancer making the possibility of mere sample chance artifact unlikely and supporting the hypothesis that genetic polymorphisms within the ADA gene could be involved in the susceptibility to solid tumors. Genetic variability within the ADA gene may influence adenosine concentration and in turn the immune response by lymphocytes in solid tumors. On the other hand ADA molecules acting as ecto-enzyme may be involved in the transduction of signals in the cell surface with important effects on tumor development. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)

Hyperhaploid uterine mesenchymal tumors – a novel genetic subgroup?

Tue, 08 Mar 2016 00:00:00 +0100

In this report, we describe hyperhaploidy in a case of an endometrial stromal nodule of a 50 year old woman who underwent hysterectomy because of symptomatic uterine fibroids. (Source: Cancer Genetics and Cytogenetics)

MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation.

Tue, 08 Mar 2016 00:00:00 +0100

In this study, we analyzed the gene expression profiles of gynecological CSCs/CICs isolated as aldehyde dehydrogenase high (ALDH(high)) cells, and found that MAPK13, PTTG1IP, CAPN1 and UBQLN2 were preferentially expressed in CSCs/CICs. MAPK13 is expressed in uterine, ovary, stomach, colon, liver and kidney cancer tissues at higher levels compared with adjacent normal tissues. MAPK13 gene knockdown using siRNA reduced the ALDH(high) population and abrogated the tumor-initiating ability. These results indicate that MAPK13 is expressed in gynecological CSCs/CICs and has roles in the maintenance of CSCs/CICs and tumor-initiating ability, and MAPK13 might be a novel molecular target for treatment-resistant CSCs/CICs. PMID: 26969274 [PubMed - as supplied by publisher] (Source: Biochemical an...

44: Complex conductivity of normal and neoplastic uterus

Sun, 06 Mar 2016 18:07:21 +0100

While not perfect, there is preoperative screening for endometrial and cervical cancer, however, occult malignancy may still complicate seemingly benign hysterectomies. Furthermore, while available screening for endometrial cancer may reduce risk of occult malignancy, it is not cost effective in the asymptomatic patient. One diagnostic method that has not been explored for the uterine body, but has shown promise in cervical, breast, prostate, and skin cancer is bioimpedance. Electrical Impedance Spectroscopy (EIS) is a non-invasive bioimpedance technique that uses electrical conductivity and permittivity to assess the pattern of current flow through biological tissue. (Source: American Journal of Obstetrics and Gynecology)

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21: Poor nationwide utilization of minimally invasive surgery in early-stage uterine cancer: An HCUP-national inpatient sample database study

Sun, 06 Mar 2016 18:07:21 +0100

Minimally invasive surgery (MIS) is a Society of Gynecologic Oncology and American College of Surgeons Commission on Cancer quality measure for early-stage endometrial cancer. Our objective was to perform a contemporary analysis of the nationwide uptake of MIS for endometrial cancer and associated inpatient complications and costs. (Source: American Journal of Obstetrics and Gynecology)

20: Laparoscopic supracervical hysterectomy (LSH) with sacrocervicopexy: The use of posterior colpotomy for uterine removal

Sun, 06 Mar 2016 18:07:21 +0100

Laparoscopic sacrocervicopexy after LSH is a common surgical procedure for correction of uterovaginal prolapse. For many surgeons using laparoscopic or robotic techniques, the uterine fundus was removed using a power morcellator, enabling the procedure to be done with small port sites. In 2014, the FDA issued guidelines suggesting that the use of these morcellators may contribute to the spread and upstaging of unsuspected uterine cancer in women undergoing hysterectomy and myomectomy. This recommendation poses new challenges to surgeons who want to continue to offer their patients a minimally-invasive approach. (Source: American Journal of Obstetrics and Gynecology)

Endometriosis-associated Malignancy.

Sun, 06 Mar 2016 13:36:02 +0100

Authors: Krawczyk N, Banys-Paluchowski M, Schmidt D, Ulrich U, Fehm T Abstract Endometriosis is a common condition in women of reproductive age. According to several epidemiological studies endometriosis may be associated with increased risk of various malignancies. However, endometriosis-associated malignancy (EAM) is defined by certain histological criteria. About 80 % of EAM have been found in the ovary, whereas 20 % are localized in extragonadal sites like intestine, rectovaginal septum, abdominal wall, pleura and others. Some authors suggest that EAM arise from atypical endometriosis as an intermediate lesion between endometriosis and cancer. Moreover, a number of genetic alterations, like loss of heterozygosity (LOH), PTEN, ARID1 A and p53 mutations have been found in b...

A new hysteroscopic risk scoring system for diagnosing endometrial hyperplasia and adenocarcinoma

Sat, 05 Mar 2016 00:00:00 +0100

Conclusions The proposed scoring system showed good diagnostic performance, especially in relation to endometrial cancer, and may represent a useful diagnostic tool, mainly for operators with less experience. (Source: Journal of Minimally Invasive Gynecology)

Evaluation of the diagnostic role of transvaginal ultrasound measurements of endometrial thickness to detect endometrial malignancy in asymptomatic postmenopausal women

Sat, 05 Mar 2016 00:00:00 +0100

Conclusions Routine use of endometrial thickness measurement with TVUS does not seem to be an effective diagnostic tool for endometrial cancer because it has a low diagnostic performance in asymptomatic postmenopausal women. Further prospective studies are required to assess the endometrial thickness measurement with TVUS as a screening method in these women. (Source: Archives of Gynecology and Obstetrics)

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The Importance of Detoxification for Health

Fri, 04 Mar 2016 21:45:39 +0100

Spring is upon us, a perfect time of year for detoxification. As the seasons change, many of us are motivated to do 'spring cleaning' in our homes and gardens. The same need applies to our bodies. When the body is detoxified, it can function more efficiently and gain resilience. Physicians have been seeing increasing symptoms of toxicity in their patients over the last few decades. Hormone imbalances, obesity, mental fog, memory loss, fatigue, lack of vitality, metabolic syndrome, sleep disturbances are all manifestations of a toxic body. Conventional medicine does not acknowledge toxicity as an important health issue, but numerous studies have shown this to be the underlying cause of many chronic symptoms experienced today, including the rising rates of cancer over the past two decades....

Gastrin‐releasing peptide receptor (GRPr) promotes EMT, growth, and invasion in canine prostate cancer

Fri, 04 Mar 2016 00:00:00 +0100

CONCLUSIONThese data demonstrated that the GRPr is important in prostate cancer growth and progression and targeting GRPr may be a promising strategy for treatment of prostate cancer. Prostate. © 2016 Wiley Periodicals, Inc. (Source: The Prostate)

Other Gynecologic Pathology in Endometrial Cancer Patients.

Thu, 03 Mar 2016 10:52:05 +0100

CONCLUSIONS: More than half of EMC patients had other gynecologic lesions including benign and malignant tumors. Surgical lesions were also found in more than one-tenth of patients. Careful pre-operative evaluation and intra-operative inspection are advised for proper management and better prognosis. PMID: 26925668 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)

The Value of Preoperative CA 125 Levels in Prediction of Myometrial Invasion in Patients with Early-stage Endometrioid- type Endometrial Cancer.

Thu, 03 Mar 2016 10:52:05 +0100

CONCLUSIONS: This study demonstrates that preoperative serum CA-125 values maybe used as a predictive test in patients with early stage endometrioid-type endometrium cancer, and as a prognostic factor alone. Further studies should be conducted to identify different CA-125 cut-off values in patients with low risk endometrial cancer. PMID: 26925634 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)

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Comparison of Survival Outcomes in Women with Unsuspected Uterine Malignancy Diagnosed After Laparotomic Versus Laparoscopic Myomectomy: A National, Population-Based Study

Thu, 03 Mar 2016 05:34:45 +0100

Conclusions There was no difference in the overall survival of women with UUM with or without endometrial cancer between groups. The incidence of UUM with or without endometrial cancer diagnosed after myomectomy was quite low. (Source: Annals of Surgical Oncology)

Laparoscopic Vaginal-Assisted Nerve-Sparing Radical Trachelectomy

Thu, 03 Mar 2016 00:00:00 +0100

Conclusion This video demonstrates a reproducible laparoscopic technique for radical trachelectomy with a nerve-sparing technique. The vaginal route was used at the moment of sectioning the cervix/isthmus to permit adequate margin evaluation. (Source: Journal of Minimally Invasive Gynecology)

Dosimetric advantages of proton therapy compared with photon therapy using an adaptive strategy in cervical cancer.

Thu, 03 Mar 2016 00:00:00 +0100

Conclusion This study demonstrates the feasibility of IGAPT in cervical cancer using a plan-library based plan-of-the-day approach. Compared to photon-based IGART, IGAPT maintains target coverage while significant dose reductions for the bladder, bowel and rectum can be achieved. PMID: 26934821 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

Racial disparity in survival of patients with uterine serous carcinoma: Changes in clinical characteristics, patterns of care and outcomes over time from 1988 to 2011.

Thu, 03 Mar 2016 00:00:00 +0100

CONCLUSIONS: Significant improvement in outcome was noted in both racial groups over time. However, African American patients continued to have worse outcome than white patients over time. PMID: 26948694 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Doctors May Have Found Way To Diagnose Ovarian Cancer Earlier

Wed, 02 Mar 2016 22:00:48 +0100

BOSTON (CBS) – About 20,000 women are diagnosed with ovarian cancer every year and the symptoms can be vague, like abdominal pain or bloating which makes the diagnosis challenging. A new report from the National Academies of Sciences, Engineering, and Medicine says we need to have a better understanding of ovarian cancer in order to improve diagnosis, treatment, and survival. The report says one step is to see ovarian cancer not as a single disease but a collection of different types of cancer that usually start in the uterus or the Fallopian tubes. Dr. Beth Karlan from Cedars Sinai Medical Center explains, “The ovary itself is such a fertile area for the cells to implant with lots of blood vessels and nutrients that they don’t actually begin on the ovary, but they actually m...

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Type 1 diabetes tied to risk for a wide range of cancers

Wed, 02 Mar 2016 19:24:22 +0100

(Reuters Health) – People with type 1 diabetes are more likely than the general population to develop cancers of gastric organs and the kidneys, as well as endometrium and ovaries for women, according to a large new analysis. (Source: Reuters: Health)

Hereditary non-BRCA gynaecological tumors.

Wed, 02 Mar 2016 16:12:02 +0100

Authors: Vellone VG, Paudice M, Varesco L Abstract Early diagnosis and proper management of gynecologic malignancies represent a challenge in modern oncology. A growing interest has arisen around the gynecological manifestations of hereditary cancer syndromes. In particular, the discovery of the BRCA1 and BRCA2 genes in ovarian cancer and the mismatch repair genes (MMR) in endometrial carcinoma has revolutionized our approach to the diagnosis and screening of women for ovarian and uterine cancers. The clinical, genetic and pathological features of hereditary cancer syndromes with gynecological manifestations are reviewed focusing on Lynch Syndrome, also known as Hereditary Nonpolyposis Colorectal Carcinoma (HNPCC), Peutz-Jeghers Syndrome, Cowden Syndrome or Multiple Hamartoma Syndr...

Uterine responses to feeding soy protein isolate and treatment with 17β-estradiol differ in ovariectomized female rats.

Wed, 02 Mar 2016 00:00:00 +0100

In this study, female rats were fed AIN93G diets made with casein (CAS) or soy protein isolate (SPI) from postnatal day (PND) 30, ovariectomized on PND 50 and infused with 5μg/kg/d 17β-estradiol (E2) or vehicle. E2 increased uterine wet weight (P<0.05). RNAseq analysis revealed that E2 significantly altered expression of 1991 uterine genes (P<0.05). SPI feeding had no effect on uterine weight and altered expression of far fewer genes than E2 at 152 genes (P<0.05). Overlap between E2 and SPI genes was limited to 67 genes. Functional annotation analyzes indicated significant differences in uterine biological processes affected by E2 and SPI and little evidence for recruitment of estrogen receptor (ER)α to the promoters of ER-responsive genes after SPI feeding. The major E2 up-reg...

Prevalence and Factors Associated with Cognitive Deficit in Women with Gynecologic Malignancies.

Wed, 02 Mar 2016 00:00:00 +0100

CONCLUSIONS: There was a high prevalence of cognitive deficit in women with gynecologic malignancies. The association of low cognition with report of clinically significant pain, but not with use of opioid pain medications, should be further explored. Research is needed to evaluate the impact of cognitive deficits on treatment adherence and outcomes for women with gynecologic malignancies. PMID: 26946094 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Is Type 1 Diabetes Linked to Raised Risk of Certain Cancers?

Tue, 01 Mar 2016 16:03:13 +0100

TUESDAY, March 1, 2016 -- Having type 1 diabetes may raise the risk of some cancers, but lower the risk of others, a new study suggests. A higher risk was seen for cancers of the stomach, liver, pancreas, endometrium, ovary and kidneys. But a... (Source: - Daily MedNews)

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Mixed Endometrioid and Clear Cell Carcinoma of the Endometrium: A Plethora of Issues for the Diagnostic Pathologist

Tue, 01 Mar 2016 06:00:00 +0100

Abstract: A case of mixed endometrioid and clear cell (CCC) endometrial carcinoma with ovarian and peritoneal metastasis of the CCC component is presented. This raised several diagnostic issues, beginning with the morphological recognition of CCC. It is increasingly recognized that CCC is a rare subtype in the endometrium, raising questions regarding its clinical connotations. Traditionally regarded as a type 2 aggressive histotype, there are current efforts to assess its true incidence and place within the clinical and molecular spectrum of endometrial carcinomas. Both mixed carcinomas and CCC fall into the category of tumors currently acknowledged to show “ambiguous” morphology, that is, those in which morphology does not reliably indicate clinical behavior. As the 4 major molecular ...

Infective Endocarditis and Cancer Risk: A Population-Based Cohort Study

Tue, 01 Mar 2016 06:00:00 +0100

This study investigated the possible relationship between endocarditis and overall and individual cancer risk among study participants in Taiwan. We used data from the National Health Insurance program of Taiwan to conduct a population-based, observational, and retrospective cohort study. The case group consisted of 14,534 patients who were diagnosed with endocarditis between January 1, 2000 and December 31, 2010. For the control group, 4 patients without endocarditis were frequency matched to each endocarditis patient according to age, sex, and index year. Competing risks regression analysis was conducted to determine the effect of endocarditis on cancer risk. A large difference was noted in Charlson comorbidity index between endocarditis and nonendocarditis patients. In patients with e...

90-Year-Old With Cancer Says No To Chemo And Yes To Travel And Camper

Mon, 29 Feb 2016 22:39:55 +0100

At 90, one woman doesn’t care to see the inside of any more hospitals. She would much rather see the world. When a cancerous mass was detected on Norma’s uterus the day after her husband of 67 years, Leo, was admitted to hospice, she decided to trek on with her life the best way she knew how -- to fully live it. She decided to snub assisted living and treatment, in favor of going on a road trip with her son, Tim, daughter-in-law, Ramie and their 8-year-old poodle, Ringo, in a 36-foot motor home. “I'm having the time of my life!" Norma told The Huffington Post. “I’m done with doctors.” Two days after her husband died, Norma and her family were sitting in an OB-GYN office talking about her treatment options that involved surgery, radiation and chemothera...

History of uterine leiomyoma and risk of endometrial cancer in black women

Mon, 29 Feb 2016 00:00:00 +0100

Conclusions In this large cohort of black women, a history of UL was positively associated with endometrial cancer, particularly type II/III tumors. The strongest association was observed for cancer diagnosed within 2 years of UL diagnosis, a finding that might be explained by greater surveillance of women with UL or misdiagnosis of cancer as UL. However, an association was also observed for cancer reported ≥10 years after UL diagnosis. (Source: Cancer Causes and Control)

The Role Of Immunohistochemical Adrenomedullin And Bcl-2 Expression In Development Of Type-1 Endometrial Adenocarcinoma

Sun, 28 Feb 2016 00:00:00 +0100

Conclusions Our findings showed that AM expression increased in progression from benign endometrium to EIN and type-1 adenocarcinoma while expression of Bcl-2 decreased in transition from EIN to carcinoma. (Source: Pathology Research and Practice)

Triple synchronous invasive malignancies of the female genital tract in a patient with a history of leukemia: a case report and review of the literature

Sun, 28 Feb 2016 00:00:00 +0100

Conclusion The incidental diagnosis of more than one tumor is often a post-operative finding, usually with the detection of low-stage neoplasms. Multiple synchronous gynecologic cancers have a better prognosis than metastatic or advanced primitive disease. In a patient with multiple neoplasms, the prognosis is determined by the tumor with the worst prognosis. (Source: Pathology Research and Practice)

Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer

Sat, 27 Feb 2016 00:00:00 +0100

Abstract Recent molecular and pathological studies suggest that endometriosis may serve as a precursor of ovarian cancer (endometriosis-associated ovarian cancer, EAOC), especially of the endometrioid and clear cell subtypes. Accordingly, this study had two cardinal aims: first, to obtain mutation profiles of EAOC from Taiwanese patients; and second, to determine whether somatic mutations present in EAOC can be detected in preneoplastic lesions. Formalin-fixed paraffin-embedded (FFPE) tissues were obtained from ten endometriosis patients with malignant transformation. Macrodissection was performed to separate four different types of cells from FFPE sections in six patients. The four types of samples included normal endometrium, ectopic endometriotic lesion, atypical endometriosis...

The role of immunohistochemical adrenomedullin and Bcl-2 expression in development of type-1 endometrial adenocarcinoma: Adrenomedullin expression in endometrium.

Sat, 27 Feb 2016 00:00:00 +0100

CONCLUSIONS: Our findings showed that AM expression increased in progression from benign endometrium to EIN and type-1 adenocarcinoma while expression of Bcl-2 decreased in transition from EIN to carcinoma. PMID: 26972419 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)

Triple synchronous invasive malignancies of the female genital tract in a patient with a history of leukemia: A case report and review of the literature.

Sat, 27 Feb 2016 00:00:00 +0100

CONCLUSION: The incidental diagnosis of more than one tumor is often a post-operative finding, usually with the detection of low-stage neoplasms. Multiple synchronous gynecologic cancers have a better prognosis than metastatic or advanced primitive disease. In a patient with multiple neoplasms, the prognosis is determined by the tumor with the worst prognosis. PMID: 26972418 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)

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Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia.

Thu, 25 Feb 2016 14:52:02 +0100

Conclusion. We cannot confirm the osteoprotective effects of 8-PN at a cancer-safe dose in primary affected osteoporotic bones. Higher concentrations of 8-PN are not advisable for safety reasons. Adjunctive therapy with WBVV demonstrates no convincing effects on bones. PMID: 26904278 [PubMed] (Source: Journal of Nutrition and Metabolism)

Near infrared sentinel lymph node mapping with Indocyanine Green (ICG) using the VITOM exoscope for open surgery in case of gynecological malignancies

Thu, 25 Feb 2016 00:00:00 +0100

We report our preliminary experience in 12 women underwent surgical nodal staging for early stage vulvar and uterine or cervical cancer. Surgical and pathological outcomes were described. Moreover the surgical staff evaluated the intraoperative image quality, the handling and docking of the VITOM system, and assessed its teaching value. The general impression of the surgical staff was that the VITOM system was easy to use and that the images quality of the anatomic structures was impressive. Traditionally open SLN mapping with ICG appears to be easy to perform and reproducible, therefore representing a new tool in the management of patients with gynecological malignancies. Moreover, we believe that this technology has a high potential as an operative teaching and learning modality for trai...

Clinicopathological Features of Second Primary Colorectal Cancer Incidentally Identified by 18F-FDG-PET.

Wed, 24 Feb 2016 20:16:02 +0100

In this study, we investigated the clinicopathological features of 15 cases of second primary colorectal cancer incidentally detected by PET during other cancer evaluation in patients who underwent surgery. We also discussed the significance of FDG-PET in evaluating cancer status. None of the patients had undergone FDG-PET for suspected colorectal disease; 6 were being evaluated by FDG-PET for lung cancer, 5 for nasopharyngeal or laryngeal cancer, 3 for gastrointestinal cancer, and 1 for uterine cancer. The average tumor size was 36.1 ± 14.4 mm (range, 25-70 mm) and the mean maximum standardized uptake value (SUVmax) was 11.9 ± 6.0 (range, 3.0-29.6). Although 4 cases (26.7%) had distant metastasis, 3 (20%) were Tis or T1 cancer, 3 (20%) were T2 cancer. Of the 15 cases, 6 (40%) could have...

Vaginal cancer possibly caused by pessary and immunocompromised condition: Multiple risk factors may influence vaginal cancer development

Wed, 24 Feb 2016 00:00:00 +0100

Abstract Primary cancer of the vagina is a rare entity, comprising only 1–2% of all gynecologic malignancies. Infection of human papillomavirus, immunocompromised condition, and chronic irritation of the vagina by prolonged pessary usage are known to contribute to the development of vaginal cancer. We experienced a rare case of vaginal cancer that occurred after usage of a vaginal pessary while the patient was prescribed with oral prednisolone for idiopathic interstitial pneumonia. Previous reports of vaginal cancer that occurred after pessary usage are mostly neglected pessaries, but in this case the patient was managed properly. We suspect that her immunocompromised condition, as well as her pessary usage, may have accelerated the development of vaginal cancer. The presence of multiple...

Near infrared sentinel lymph node mapping with Indocyanine Green (ICG) using the VITOM exoscope for open surgery in case of gynecological malignancies

Wed, 24 Feb 2016 00:00:00 +0100

We report our preliminary experience in 12 women underwent surgical nodal staging for early stage vulvar and uterine or cervical cancer. Surgical and pathological outcomes were described. (Source: The Journal of Minimally Invasive Gynecology)

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Near-Infrared Sentinel Lymph Node Mapping With Indocyanine Green Using the VITOM II ICG Exoscope for Open Surgery for Gynecologic Malignancies

Wed, 24 Feb 2016 00:00:00 +0100

We report our preliminary experience in 12 women who underwent surgical nodal staging for early-stage vulvar and uterine or cervical cancer. (Source: The Journal of Minimally Invasive Gynecology)

An Assessment of Prognostic Factors, Adjuvant Treatment, and Outcomes of Stage IA Polyp-Limited Versus Endometrium-Limited Type II Endometrial Carcinoma

Tue, 23 Feb 2016 21:34:51 +0100

Conclusions: Clinical outcomes of surgical stage IA type II polyp- or endometrium-limited high-grade epithelial EC are equally favorable regardless of histologic subtype or adjuvant therapy received. The benefit of adjuvant therapy in this select group remains to be determined. (Source: International Journal of Gynecological Cancer)

Gemcitabine and Docetaxel Compared With Observation, Radiation, or Other Chemotherapy Regimens as Adjuvant Treatment for Stage I-to-IV Uterine Leiomyosarcoma

Tue, 23 Feb 2016 21:34:51 +0100

Conclusions: There was no difference in PFS or OS in women with uLMS treated with adjuvant gemcitabine-docetaxel versus those who were observed or received radiation only or a chemotherapy regimen other than gemcitabine-docetaxel. There is a need to identify novel therapies to treat this aggressive disease. (Source: International Journal of Gynecological Cancer)

Expression of PTEN and β-Catenin and Their Relationship With Clinicopathological and Prognostic Factors in Endometrioid Type Endometrial Cancer

Tue, 23 Feb 2016 21:34:51 +0100

Conclusions: PTEN and β-catenin expressions cannot be used to determine prognosis in patients with EC as PTEN and β-catenin staining status were found to have no significant effect on 5-year overall survival and disease-free survival. Positive staining of PTEN may be associated with increased myometrial invasion. Meta-analyses and broader studies are needed to evaluate the prognostic value of PTEN and β-catenin in EC. (Source: International Journal of Gynecological Cancer)

Feasibility Study of Adjuvant Chemotherapy Using Taxane Plus Carboplatin for High-Risk Patients With Uterine Cervical Non-Squamous Cell Carcinoma After Radical Hysterectomy

Tue, 23 Feb 2016 21:34:51 +0100

Conclusions: Taxane and CBDCA combination chemotherapy, especially DC chemotherapy, may be one of the useful adjuvant treatments for high-risk stage IB–IIB patients with uterine cervical non-squamous cell carcinoma after radical hysterectomy. (Source: International Journal of Gynecological Cancer)

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Radical Hysterectomy and Total Abdominal Vaginectomy for Primary Vaginal Cancer

Tue, 23 Feb 2016 21:34:51 +0100

Abstract: The aim of this surgical video is to demonstrate en bloc radical removal of uterus and vagina in a patient with clinical early-stage vaginal cancer. Surgical treatment was offered to our patient for clinical early-stage primary vaginal cancer. An en bloc radical hysterectomy, systematic pelvic lymphadenectomy, and total abdominal vaginectomy were performed. Postoperative adjuvant radiation or chemotherapy was not recommended for completely resected pathologic stage I disease with no lymph node involvement and negative surgical margins. Radical surgery can be a treatment option for selected patients with primary vaginal cancer. (Source: International Journal of Gynecological Cancer)

Clinical Characteristics and Prognosis of Unexpected Uterine Sarcoma After Hysterectomy for Presumed Myoma With and Without Transvaginal Scalpel Morcellation

Tue, 23 Feb 2016 21:34:50 +0100

Conclusions: The overall incidence of unexpected uterine sarcoma after total hysterectomy for presumed leiomyoma was low. Low-grade endometrial stromal sarcoma was the dominant subtype of unexpected uterine sarcoma in the present study. Currently, incidental TVSM of unexpected ESS during total laparoscopic hysterectomy seemed to cause no additional increase in sarcoma dissemination in the short-term. (Source: International Journal of Gynecological Cancer)

Tubal Ligation and Risk of Endometrial Cancer: Findings From the Women’s Health Initiative

Tue, 23 Feb 2016 21:34:50 +0100

Conclusions: We examined the largest patient cohort to date in an effort to determine the impact of BTL on endometrial cancer risk. In the WHI trial, we observed no overall effect of BTL on the risk of type I or type II endometrial cancer, suggesting that patients undergoing this popular birth control method likely do not have an associated change in their baseline risk for endometrial cancer. (Source: International Journal of Gynecological Cancer)

Utilization and Role of Adjuvant Radiotherapy and Chemotherapy for Uterine Clear Cell Carcinoma: A National Cancer Data Base Analysis

Tue, 23 Feb 2016 21:34:50 +0100

Conclusions: In this hospital-based registry analysis of UCCC, adjuvant CT + RT significantly reduced the risk of death, reaching statistical significance for stage III to IVA patients. (Source: International Journal of Gynecological Cancer)

Exploring Morphologic and Molecular Aspects of Endometrial Cancer Under Progesterone Treatment in the Context of Fertility Preservation

Tue, 23 Feb 2016 21:34:50 +0100

Conclusions: We found that activating molecular alterations in either Wnt or PI3K/Akt signaling pathways did not predict resistance to progesterone treatment. It seems that morphological response goes along with disappearance of the established mutations. This exploratory study suggests that Wnt or PI3K/Akt status is unable to predict response to progesterone treatment in patients with EEC. (Source: International Journal of Gynecological Cancer)

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Role of Adjuvant Therapy for Stage IA Serous and Clear Cell Uterine Cancer: Is Observation a Valid Strategy?

Tue, 23 Feb 2016 21:34:50 +0100

Conclusions: Observation seems to be a valid strategy in those patients with stage IA serous and clear cell carcinoma without myometrial invasion. The presence of any myometrial invasion may confer a higher risk of recurrence, although further studies are needed to determine the optimal adjuvant treatment regimen. (Source: International Journal of Gynecological Cancer)

IV Therapy “Cocktail” For a Cancer Patient

Fri, 19 Feb 2016 17:40:19 +0100

Today, I want to talk to you about my patient D.B. A key treatment I offer at the Sears Institute for Anti-Aging Medicine turned her life around and boosted her chances of recovering from cancer. D.B had been a vivacious 47-year-old woman, who’d always led a healthy life. For years, she’d watched her diet carefully and exercised regularly. But then she was diagnosed with endometrial cancer. This is cancer of the inner lining of the uterus. When she came to my clinic, she’d already undergone a hysterectomy and chemotherapy. Unsurprisingly, she felt terrible. She was pale. She felt lethargic and she was experiencing severe mental fog. Every moment of her life had become a struggle. It was clear right away that D.B. was deficient in several important nutrients. It was also clear her im...

Extramedullary Acute Lymphocytic Leukemia Presenting With Abnormal Uterine Bleeding

Fri, 19 Feb 2016 14:08:32 +0100

Leukemia is the most common childhood cancer accounting for almost a third of pediatric cancers. The majority (75%) of cases are acute lymphocytic leukemia (ALL), while most of the remaining cases are acute myelogenous leukemia (AML). The current 5 year survival rate for children with ALL is greater than 85%. However, relapse of ALL occurs in 15-20% of patients. Of these relapses, 2–6% occur exclusively in extramedullary sites, most commonly in the central nervous system and testes. There are case reports in the literature of relapse to other organs including the bones, breasts, prostate, gastric and hepatic systems. (Source: Journal of Pediatric and Adolescent Gynecology)

Stage-III and -IV endometrial cancer: A single oncology centre review of 104 cases.

Fri, 19 Feb 2016 10:55:03 +0100

The objective of this study was to evaluate the clinicopathological characteristics, treatment and prognosis of advanced endometrial cancer (EC). Patients who underwent surgery for advanced EC between January 1995 and December 2012 were retrospectively reviewed. Patients with missing data, concurrent cancers or uterine sarcomas and those who did not undergo surgery were excluded. The effects of clinicopathological factors on progression-free survival (PFS) and overall survival (OS) were analyzed. A total of 104 patients were included. Most presented with endometrioid histology (74%) and stage-III disease (87.5%), and 76.9% underwent optimal cytoreduction. A multivariate analysis confirmed that lymphovascular space invasion (LVSI) is an independent poor prognostic factor for PFS [odds ratio...

Regulation of cancer‐related genes – Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt – expression in β‐naphthoflavone‐treated mice by miroestrol

Fri, 19 Feb 2016 00:00:00 +0100

ConclusionMR may be superior to E2 as it downregulates expression of CYP1. Moreover, MR normalized expression of both NQO1 and COMT, the protective enzymes, in murine liver and uteri. These results support the use of MR as an alternative supplement for menopausal women, MR having the extra benefit of reducing cancer risk. (Source: Journal of Pharmacy and Pharmacology)

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