Last Build Date: Tue, 29 Mar 2016 16:49:34 +0100
Tue, 29 Mar 2016 14:27:36 +0100Conclusions: Life expectancy increased for both sexes, across all racial/ethnic groups, and for both the US-born and the foreign-born. Disparities in life expectancy decreased as overall life expectancy increased. Decreased mortality among older adults and from heart disease, cancer, and HIV infection accounted for most of the increases. (Source: Journal of Public Health Management and Practice)
Tue, 29 Mar 2016 10:33:01 +0100This study underscores the need for intervention programs aimed at LDLs to reduce extended time in the sun and increase use of sun protective measures when working outdoors. PMID: 27019656 [PubMed - as supplied by publisher] (Source: Dermatology Research and Practice)
Tue, 29 Mar 2016 10:23:47 +0100The same week she was set to graduate from college, Adalis Martinez found out she had colon cancer (Source: Health News: CBSNews.com)
Tue, 29 Mar 2016 09:23:40 +0100Abstract: Every year cervical cancer affects around 528000 women and causes 266000 deaths worldwide with 80% of deaths occurring in less developed countries with a concomitant 18-fold difference in mortality occurring between developed and developing countries. Cervical cancers is caused by the Human Papilloma Virus (HPV) with the oncogenic types 16 and 18 accounting for 70% of invasive disease. Other cancers associated with HPV infection include vaginal, vulvar, penile, oropharyngeal and anal cancers. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:40 +0100Abstract: Intensive care units are often the focus of epidemics – these include novel emerging pathogens as well as endemic multi-resistant organisms or even less common environmental pathogens or common hospital acquired infections. The reasons for this are simple – patient in the intensive care units are vulnerable – many are immunocompromised either by their underlying diseases or because of the therapeutic agents used to treat their cancers or rheumatological conditions. They also have numerous invasive medical devices which can put them at risk of device associated infections and many outbreaks have been documented in intensive care units all across the world from breaks in infection control in the management of patients with invasive medical devices. (Source: International Jour...
Tue, 29 Mar 2016 09:23:40 +0100Abstract: With the advent of antiretroviral therapy (ART), HIV has shifted to a chronic manageable condition, even in resource-limited settings. Now, the long-term effects of being on ART and living with HIV are emerging. These include the adverse effects of long-term ART and morbidity due to non AIDS complications such as cardiovascular, hepatic, renal, metabolic and neurocognitive disease, cancers and ageing as well as complications due to hepatitis B and C co-infection. Although first and second-line antiretrovirals are available in resource-limited settings, new antiretrovirals are urgently needed in order to sustain HIV as a chronic manageable condition. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:40 +0100Background: Helicobacter pylori is a causative agent of gastritis, gastric ulcer, duodenal ulcer and gastric cancer. Clarithromycin is often used in the treatment of H. pylori infections in Sri Lanka. Although resistance of H. pylori to clarithromycin has been reported in other countries the situation in Sri Lanka is an enigma. We determined clarithromycin resistance of H. pylori by detecting two major point mutations (A2142G and A2143G) in the 23S rRNA gene. Further we assessed the histology of gastric mucosa of dyspeptic patients as a reasonably good predictor of cancer risk specially, in H. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:39 +0100Background: Numerous studies have implicated that persistent colonization of the stomach by Helicobacter pylori (H. pylori) is strongly associated with development of gastric cancer (GC). Micro-RNAs (miRNAs) are a wide class of small, noncoding RNAs that negatively regulate protein expression at the posttranscriptional level. The multi-dimensional roles of microRNAs in gene regulation and tumorigenesis have prompted to explore their potentials in diagnosis and treatment of various cancers including gastric cancer. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:39 +0100Background: Cancer arises through a multistep process, fuelled by deregulation of pathways in control of cellular growth and proliferation. The very same signalling cascades are targeted by infectious pathogens en route to subversion of the host to their benefit. One such pathogen—the bacterium Salmonella Typhi—is epidemiologically associated with an increased incidence of gallbladder carcinoma, as both are highly prevalent in India while relatively rare in the Western world. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:39 +0100Background: Blood stream infections are an important cause of morbidity and mortality especially in febrile neutropenic patients. Escherichia coli (E. coli) is a pathogen of great concern in immunosuppressed patients. On time diagnosis and appropriate medication will be the best way to save the lives of the affected ones. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:38 +0100Background: The human papillomavirus (HPV) is the main cause of cervical cancer in developing countries. HPV is common in all socioeconomic groups and is spread all over the world. There are more than 100 types of HPV which are divided into high risk and low risk groups. Molecular method is one of the rapid and accurate methods to study HPV genotypes. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:37 +0100Background: The spectrum of mycotic disease continues to expand well beyond the familiar entities of candidiasis and aspergillosis. Major advances in anticancer treatment have contributed to an increased frequency of severe fungal infections in patients with neoplastic diseases. Incidence due to filamentous fungi becomes life-threatening and their diagnosis and treatment can be challenging, especially in species with intrinsic resistance. Diagnosis of filamentous fungi in both the clinic and the laboratory remains difficult, leading to unsatisfactory treatment and high mortality rates. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:37 +0100Background: Antimicrobial stewardship programs (ASP) in collaboration with infection control have been shown to reduce rates of hospital-acquired infections (HAI) and prevent development of resistant organisms. ASP ensures the medical staff is appropriately educated on protocols developed by infection control and monitors the use of antibiotics to reduce the risk of C. difficile and other multi-drug- resistant organisms. These services are imperative in hematology/oncology patients who are at elevated risk for acquiring HAIs due to immunosuppression, chronic intravenous access, and frequent hospitalizations. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:36 +0100Background: thyroid tuberculosis is a rare disease, this is the probably the polymorphic clinical presentation and confusing with other thyroid diseases including cancer and thyroid hemorrhagic cysts. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:36 +0100Background: Globally, Africa has the highest prevalence of HIV, schistosomiasis and another neglected entity: cervical cancer. Genital schistosomiasis manifests in lesions that are hypothesized to link with HIV and cervical atypia. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:36 +0100Background: Interleukin 18 (IL-18) is a cytokine that mediates Th1 response by inducing interferon-gamma (IFN-γ) production in T cells and natural killer cells. Genetic polymorphisms in the IL-18 gene have been found to be associated with its expression in cancer, tuberculosis, HBV infection and various other diseases. Lower plasma level of IL-18 in visceral leishmaniasis patients might be associated with polymorphisms in the coding gene. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:36 +0100Background: Increased life years of HIV positive patients has increased the number of HIV related chronic conditions and cancers. On the other hand, chemotherapy and radiotherapy remain key treatment methods for cancer, which could exacerbate the immunosuppression status. There is limited data on the outcome of cancer therapy in HIV positive patients on HAART in South Africa. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:36 +0100Background: Regardless of general perception as potentially dangerous pathogens, viruses have been exploited and used as vaccine agents or as carriers for gene therapy. Similar positive effects have been observed in case of cancer patients getting infected with viruses, where infection has resulted in temporary tumor regression. Hence, the development of a recombinant virus that selectively infects and kills cancer cells can be a promising anti-cancer tool in near future. Here we made an attempt to generate an oncolytic virus using Measles viral genome (Edmonston strain) backbone and to further arm this recombinant virus with non viral genes of known anti-proliferative activity to enhance its antitumor activity. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:35 +0100The objective of the study was to investigate sero-prevalence of hepatitis B surface antigen and assess risk factors among pregnant women. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:35 +0100Background: Almost half of penile cancers and the majority of penile warts are associated with the two HR types (HPV 16 and HPV 18) and two LR HPV types (HPV 6 and HPV 11), respectively. It is therefore important to document the burden HPV associated diseases of the penis and identify the HPV types associated with the diseases. HPV E6 and E7 mRNA detection is the best indicator of HPV status that is clinically relevant as it indicate transcriptionally active HR HPV infection in lesions. In HR HPV infection an increase in E6 and E7 mRNA expression causes an overexpression of p16INK4A and thus used as a cellular correlate of the increased expression of HR HPV E6 and E7 mRNA in cervical samples. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 09:23:35 +0100Background: Cervical cancer is the most common malignancy in Indian women and approximately 130,000 women fall prey to cervical cancer every year. HPV DNA testing can be used as an adjunct to cytological screening of cervical samples of above 30 year old women and can be used as an optional test for follow-up in women who have slightly abnormal Pap test results. The aim of the study was to assess the HPV 16 and 18 status in cervical cancer patients and in healthy women visiting JIPMER, Pondicherry. (Source: International Journal of Infectious Diseases)
Tue, 29 Mar 2016 08:06:22 +0100UCLA researchers have developed a software program that simulates the response of the human thyroid hormone regulation system to a variety of treatments and diseases. The open-source program, Thyrosim, can be used by clinicians, researchers and educators to accurately gauge the impacts of thyroid treatments and to develop more effective remedies for thyroid problems. The research appears on the cover of the peer-reviewed journal Thyroid. Principal investigator Joseph DiStefano III, a distinguished professor of computer science and medicine and chair of the UCLA Computational and Systems Biology Interdepartmental Program, developed the technology based on 50 years of research with his students. "Thyrosim offers an easy-to-use interface for a sophisticated mathematical model of the short-t...
Tue, 29 Mar 2016 07:58:29 +0100Sydney mother Marisa Calo, 30, who is battling cancer has been penning a heartfelt scrapbook so her four-year-old daughter Avia will have something to remember her by when she's gone. (Source: the Mail online | Health)
Tue, 29 Mar 2016 07:07:47 +0100ConclusionsOur large multicenter study identified ES as a rare and severe initial manifestation of active cSLE with good outcome. Diagnosis is challenging due to the lack of typical signs and symptoms of lupus and the requirement to exclude infection and primary immunodeficiency. (Source: Pediatric Blood and Cancer)
Tue, 29 Mar 2016 07:07:45 +0100CONCLUSIONSThe combination of bicalutamide and everolimus has encouraging efficacy in men with bicalutamide‐naive CRPC, thus warranting further investigation. A substantial number of patients experienced everolimus‐related toxicity. Cancer 2016. © 2016 American Cancer Society. (Source: Cancer)
Tue, 29 Mar 2016 06:46:50 +0100Amy Lewis, 32, a chartered accountant from Wetherby, West Yorkshire, only made her wedding day to Chris because she refused to believe that she was 'too young' to have cancer. (Source: the Mail online | Health)
Tue, 29 Mar 2016 06:30:00 +0100Marketing authorization granted for the treatment of castration-resistant prostate cancer patients with bone metastases (Source: Bayer Company News)
Tue, 29 Mar 2016 05:20:44 +0100Robin Givens, star of 1980s sitcom Head Of The Class and ex-wife of Mike Tyson, had mammogram and ultrasound tests done on air, to see if she had the same disease that claimed her younger sister's life. (Source: the Mail online | Health)
Tue, 29 Mar 2016 04:01:40 +0100Research into immunotherapy, which cancer experts are calling the most promising approach in decades, will get a big boost Tuesday when Michael Bloomberg and other philanthropists announce $125 million in donations to Johns Hopkins University for a new institute focused solely on the therapy and accelerated breakthroughs for patients. Michael Bloomberg, the businessman, philanthropist […] (Source: Washington Post: To Your Health)
Tue, 29 Mar 2016 04:01:36 +0100Air pollution leads to 16,000 premature births in the United States each year, leading to billions of dollars in economic costs, according to new research. Researchers behind the study, published in the journal Environmental Health Perspectives, found that preterm births associated with particulate matter—a type of pollutant—led to more than $4 billion in economic costs in 2010 due to medical care and lost productivity that results from disability. And, like many other public health issues, affected populations tend to be concentrated in low-income areas home to large numbers of minorities. “This is another piece of the evidentiary pie about why we should really be doing something about air pollution,” says Tracey Woodruff, a professor who studies reproductive healt...
Tue, 29 Mar 2016 04:00:00 +0100(Thomas Jefferson University) Increasing the total dose of radiation to patients with non-metastatic prostate cancer does not improve their long-term outcomes, according to a new study. (Source: EurekAlert! - Cancer)
Tue, 29 Mar 2016 04:00:00 +0100(University of Texas M. D. Anderson Cancer Center) TESARO, Inc., an oncology focused biopharmaceutical company, and the Institute for Applied Cancer Science at The University of Texas MD Anderson Cancer Center today announced an exclusive collaboration to discover and develop small molecule product candidates against undisclosed immuno-oncology targets. (Source: EurekAlert! - Medicine and Health)
Tue, 29 Mar 2016 02:22:41 +0100(Reuters) - A group of lawmakers is calling on the National Institutes of Health and Department of Health and Human Services to step in and reduce the cost of Medivation Inc's and Astellas Pharma Inc's prostate cancer drug Xtandi. (Source: Reuters: Health)
Tue, 29 Mar 2016 02:19:39 +0100Genetic testing helps oncologists target mutations that cause cancer and adjust treatments as the disease morphs. (Source: WSJ.com: Health)
Tue, 29 Mar 2016 02:06:08 +0100Italian trial finds the therapy was also linked to better quality of life among women in the study (Source: WebMD Health)
Tue, 29 Mar 2016 01:52:02 +0100CONCLUSION: The mGPS is an independent predictor for hospitalization in patients with lung cancer consulting at the emergency department. PMID: 27017064 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Tue, 29 Mar 2016 01:52:02 +0100CONCLUSION: An actionable oncodriver was routinely detected in nearly half of patients with advanced lung adenocarcinoma. This systematic detection may influence treatment outcomes, notably with matched targeted therapy. PMID: 27017063 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Tue, 29 Mar 2016 01:07:10 +0100Is ultrasound as good as mammography for detecting breast cancer? I've read that women can have either test. I find mammograms painful and would like to avoid them if I can. (Source: Dr. Weil Q and A)
Tue, 29 Mar 2016 00:48:26 +0100Alan Mozes, HealthDay News Acupuncture can help alleviate hot flashes afflicting many breast cancer patients, new Italian research says. (Source: Health News - UPI.com)
Tue, 29 Mar 2016 00:01:17 +0100New research based on more than 550,000 men worldwide shows that the likelihood of developing the disease decreases with coffee. (Source: the Mail online | Health)
Mon, 28 Mar 2016 23:35:45 +0100Current methods of testing, such as scans, can't usually detect if a tumour is shrinking until after multiple cycles of therapy, explain researchers from Brigham and Women's Hospital in Boston. (Source: the Mail online | Health)
Mon, 28 Mar 2016 22:52:28 +0100Experts at the American Cancer Society and University of Michigan found on average a packet of regular cigarettes cost $5 (£3.50) compared with $8.50 (£6) for disposable e-cigarettes. (Source: the Mail online | Health)
Mon, 28 Mar 2016 22:37:36 +0100This study was designed to evaluate the cardioprotective effects of X22 using cell culture studies and a high‐fat diet rat model. We observed that palmitic acid treatment in cardiac‐derived H9c2 cells induced a significant increase in reactive oxygen species, inflammation, apoptosis, fibrosis and hypertrophy. All of these changes were inhibited by treatment with X22. Furthermore, oral administration of X22 suppressed high‐fat diet‐induced oxidative stress, inflammation, apoptosis, hypertrophy and fibrosis in rat heart tissues and decreased serum lipid concentration. We also found that the anti‐inflammatory and anti‐oxidative actions of X22 were associated with Nrf2 activation and nuclear factor‐kappaB (NF‐κB) inhibition, respectively, both in vitro and in vivo. The results...
Mon, 28 Mar 2016 22:27:42 +0100Medically speaking, if you are above the age of 65, you are considered an "older adult." On conducting rounds on the cardiology unit, I find it rare to see anyone less than 65 years of age. If someone below 50 years old gets admitted, they are almost considered "pediatric" from a cardiovascular perspective. Such observations reflect the realities of modern medicine. Patients are older, more frail, have multiple co-morbidities, and have complex social issues. During the next 25 years, the population age greater than 85 years will be more than double -- from 6.3 million in 2015 to 14.1 million by 2040. Yet for my older patients, when I prescribe medications for my heart failure, or use blood thinners to treat those who come in with heart attacks, I become wary. Many commonly used drugs have ...
Mon, 28 Mar 2016 22:00:00 +0100ConclusionsPICC is a safe venous device for chemotherapy delivery. Nevertheless, a 15% rate of failure has to be taken in account when planning PICC insertion for chemotherapy purposes. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Mon, 28 Mar 2016 22:00:00 +0100Conclusion Up-regulation of miR-218 expression in renal cell carcinoma under hypoxia can result in significant and targeted down-regulation of CXCR7 expression, which could reduce cell viability, migration and invasion ability and induce apoptosis in the cancer cells. (Source: Biomedicine and Pharmacotherapy)
Mon, 28 Mar 2016 22:00:00 +0100Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): Xinfeng Ma, Jing Wei, Li Zhang, Deqiang Deng, Lianyong Liu, Xin Mei, Xiaohua He, Jianqing Tian Previous studies have demonstrated that miR-486-5p functions as a tumor suppressor or oncogene in various types of cancer. In the present study, we showed that miR-486-5p was significantly down-regulated in papillary thyroid carcinoma (PTC) tissues and cell lines, whereas miR-486-5p down-regulation inhibited PTC cell proliferation and increased apoptosis. Conversely, under-expression of miR-486-5p enhanced PTC cell proliferation and decreased apoptosis. Fibrillin-1 (FBN1) was shown to be a direct target of miR-486-5p and inversely regulated by miR-486-5p. FBN1 silencing led to decreased PTC cel...
Mon, 28 Mar 2016 22:00:00 +0100The objective of this study was to examine the anticancer effects of extract of Punica granatum (pomegranate) leaves extract (PLE) on the non-small cell lung carcinoma cell line A549, H1299 and mouse Lewis lung carcinoma cell line LL/2 in vitro, and explore its mechanisms of action. Our results have shown that PLE inhibited cell proliferation in non-small cell lung carcinoma cell line in a concentration- and time-dependent manner. Flow cytometry (FCM) assay showed that PLE affected H1299 cell survival by arresting cell cycle progression in G2/M phase in a dose-dependent manner and inducing apoptosis. Moreover, PLE could also decrease the reactive oxygen species (ROS) and the mitochondrial membrane potential (ΔYm), indicating that PLE may induce apoptosis via mitochondria-mediated apoptoti...
Mon, 28 Mar 2016 22:00:00 +0100Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): Monika Paul-Samojedny, Barbara Łasut, Adam Pudełko, Anna Fila-Daniłow, Małgorzata Kowalczyk, Renata Suchanek-Raif, Michał Zieliński, Paulina Borkowska, Jan Kowalski Glioblastoma multiforme (GBM) is the most malignant and invasive human brain tumor and it is characterized by a poor prognosis and short survival time. Current treatment strategies for GBM using surgery, chemotherapy and/or radiotherapy are ineffective. Thus new therapeutic strategies to target GBM are urgently needed. The effect of methylglyoxal (MGO) on the cell cycle, cell death and proliferation of human GBM cells was investigated. The T98G and U87MG cell lines were cultured in modified EMEM supplemented with 10% f...
Mon, 28 Mar 2016 22:00:00 +0100This article presents the protocol of a randomized controlled trial comparing a gel made with chamomile (intervention) with a cream of urea (control) to prevent radiation dermatitis in patients with head and neck cancer undergoing radiotherapy. (Source: Journal of Advanced Nursing)
Mon, 28 Mar 2016 22:00:00 +0100ConclusionsThe results of the present study suggest that PGT provided similar quality of life without a reduction in treatment interruption. However, patients with PGT had significantly less weight loss (P = 0.04) during CRT. (Source: Journal of Human Nutrition and Dietetics)
Mon, 28 Mar 2016 22:00:00 +0100Authors: Gustav Stålhammar, Nelson Fuentes Martinez, Michael Lippert, Nicholas P Tobin, Ida Mølholm, Lorand Kis, Gustaf Rosin, Mattias Rantalainen, Lars Pedersen, Jonas Bergh, Michael Grunkin & Johan Hartman (Source: Modern Pathology)
Mon, 28 Mar 2016 22:00:00 +0100Authors: Lei Huo, Yan Wang, Yun Gong, Savitri Krishnamurthy, Jing Wang, Lixia Diao, Chang-Gong Liu, Xiuping Liu, Feng Lin, William F Symmans, Wei Wei, Xinna Zhang, Li Sun, Ricardo H Alvarez, Naoto T Ueno, Tamer M Fouad, Kenichi Harano, Bisrat G Debeb, Yun Wu, James Reuben, Massimo Cristofanilli & Zhuang Zuo (Source: Modern Pathology)
Mon, 28 Mar 2016 22:00:00 +0100Identification of microRNA expression profile related to lymph node status in women with early-stage grade 1–2 endometrial cancer Modern Pathology 29, 391 (April 2016). doi:10.1038/modpathol.2016.30 Authors: Geoffroy Canlorbe, Zhe Wang, Enora Laas, Sofiane Bendifallah, Mathieu Castela, Marine Lefevre, Nathalie Chabbert-Buffet, Emile Daraï, Selim Aractingi, Céline Méhats & Marcos Ballester (Source: Modern Pathology)
Mon, 28 Mar 2016 22:00:00 +0100Publication date: Available online 28 March 2016 Source:New Horizons in Translational Medicine Author(s): R. Bhome, H.A. Al-Saihati, R.W. Goh, M.D. Bullock, J.N. Primrose, G.J. Thomas, A.E. Sayan, A.H. Mirnezami Solid tumours comprise, not only malignant cells but also a variety of stromal cells and extracellular matrix proteins. These components interact via an array of signalling pathways to create an adaptable network that may act to promote or suppress cancer progression. To date, the majority of anti-tumour chemotherapeutic agents have principally sought to target the cancer cell. Consequently, resistance develops because of clonal evolution, as a result of selection pressure during tumour expansion. The concept of activating or inhibiting other cell types within the tumour ...
Mon, 28 Mar 2016 22:00:00 +0100Conclusions The routine use of robotic assisted laparoscopic surgery may help to achieve lower conversion rates with lower ventral hernia rates and similar oncological outcomes using a minimally invasive approach in a non-selected group of patients with non-selected rectal tumours. (Source: European Journal of Surgical Oncology (EJSO))
Mon, 28 Mar 2016 22:00:00 +0100Conclusions A list of 25 shared items on pancreatic cancer coming from eleven participating registries was created, providing a basis for future prospective data collection in pancreatic cancer treatment internationally. (Source: European Journal of Surgical Oncology (EJSO))
Mon, 28 Mar 2016 22:00:00 +0100Conclusions Histological subtype and the presence of systemic metastases strongly influenced treatment choice and survival in patients with synchronous colorectal PM. These results can be used to optimize treatment strategy for patients with synchronous colorectal PM. (Source: European Journal of Surgical Oncology (EJSO))
Mon, 28 Mar 2016 22:00:00 +0100Publication date: Available online 28 March 2016 Source:European Journal of Surgical Oncology (EJSO) Author(s): L. Villeneuve, A. Thivolet, N. Bakrin, F. Mohamed, S. Isaac, P.-J. Valette, O. Glehen, P. Rousset Based on the importance of assessing the true extent of peritoneal disease, PeRitOneal MalIgnancy Stage Evaluation (PROMISE) internet application (www.e-promise.org) has been developed to facilitate tabulation and automatically calculate surgically validated peritoneal cancer index (PCI), and other surgically validated scores as Gilly score, simplified peritoneal cancer index (SPCI), Fagotti and Fagotti-modified scores. This application offers computer-assistance to produce simple, quick but precise and standardized pre, intra and postoperative reports of the extent of peri...
Mon, 28 Mar 2016 22:00:00 +0100Conclusion Luminal pathological complete response occurred in 8%, 16% of them had tumour positive nodes. The survival benefit of luminal complete response is dependent upon nodal involvement status. (Source: European Journal of Surgical Oncology (EJSO))
Mon, 28 Mar 2016 22:00:00 +0100Publication date: May 2016 Source:Urology Case Reports, Volume 6 Author(s): Jeffrey J. Tosoian, Diane K. Reyes, Michael A. Gorin, Steven Hortopan, Alan W. Partin, Kenneth J. Pienta, Ashley E. Ross, Edward M. Schaeffer The bone marrow microenvironment represents a “metastatic niche” in which prostate cancer cells may persist and evade cytotoxic therapy. In order to study the biology of prostate cancer dissemination, we have established a safe and efficient method for performing pubic bone marrow aspiration at the time of radical prostatectomy. We herein describe our experience with this technique. (Source: Urology Case Reports)
Mon, 28 Mar 2016 22:00:00 +0100We describe four cases of these ureteral strictures emphasizing pre-operative factors that may have contributed to development of the strictures, their ultimate surgical management, and the patients' short-term outcomes. (Source: Urology Case Reports)
Mon, 28 Mar 2016 22:00:00 +0100Nature Genetics 48, 473 (2016). doi:10.1038/ng0329-473a Author: Gina M DeNicola, Pei-Hsuan Chen, Edouard Mullarky, Jessica A Sudderth, Zeping Hu, David Wu, Hao Tang, Yang Xie, John M Asara, Kenneth E Huffman, Ignacio I Wistuba, John D Minna, Ralph J DeBerardinis & Lewis C Cantley (Source: Nature Genetics)
Mon, 28 Mar 2016 22:00:00 +0100Nature Genetics 48, 473 (2016). doi:10.1038/ng0329-473c Author: Cezary Cybulski, Jian Carrot-Zhang, Wojciech Kluźniak, Barbara Rivera, Aniruddh Kashyap, Dominika Wokołorczyk, Sylvie Giroux, Javad Nadaf, Nancy Hamel, Shiyu Zhang, Tomasz Huzarski, Jacek Gronwald, Tomasz Byrski, Marek Szwiec, Anna Jakubowska, Helena Rudnicka, Marcin Lener, Bartłomiej Masojć, Patrica N Tonin, Francois Rousseau, Bohdan Górski, Tadeusz Dębniak, Jacek Majewski, Jan Lubiński, William D Foulkes, Steven A Narod & Mohammad R Akbari (Source: Nature Genetics)
Mon, 28 Mar 2016 22:00:00 +0100Summary During development, cell migration plays a central role in the formation of tissues and organs. Understanding the molecular mechanisms that drive and control these migrations is a key challenge in developmental biology that will provide important insights into disease processes, including cancer cell metastasis. In this article, we discuss the Caenorhabditis elegans Q neuroblasts and their descendants as a tool to study cell migration at single‐cell resolution in vivo. The highly stereotypical migration of these cells provides a powerful system to study the dynamic cytoskeletal processes that drive migration as well as the evolutionarily conserved signaling pathways (including different Wnt signaling cascades) that guide the cells along their specific trajectories. Here, we provi...
Mon, 28 Mar 2016 22:00:00 +0100Conclusion: The key messages from the events and promotional items can help to de-stigmatise women who develop a type of cancer that is caused by a sexually transmitted virus that affects both men and women. Developing and implementing positive health education that respectfully depicts female bodies, sexuality and health behaviours through a First Nations lens is strongly warranted. (Source: Health Education Journal)
Mon, 28 Mar 2016 21:30:01 +0100NEW YORK, NY--(Healthcare Sales & Marketing Network) - Lion Biotechnologies, Inc. (LBIO), a biotechnology company that is developing novel cancer immunotherapies based on tumor-infiltrating lymphocytes (TIL), today announced the appointment of Michael T. L... Biopharmaceuticals, Oncology, PersonnelLion Biotechnologies, melanoma (Source: HSMN NewsFeed)
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSION: Human chorionic gonadotropin has among promoting pregnancy important controversial functions especially in tumor development. The mechanisms that explain the pro- and anti-carcinogenic effects are not fully understood yet. It seems to have a protective effect on breast cancer through increasing differentiation and hereby decreasing susceptibility of the mammary tissue for toxicants. This knowledge might help developing a preventive agent in the next future that uses the anti-carcinogenic effect of human chorionic gonadotropin and thereby decrease the mortality out of breast cancer. PMID: 27017252 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100Authors: Houssami N, Lång K, Bernardi D, Tagliafico A, Zackrisson S, Skaane P Abstract This pictorial review highlights cancers detected only at tomosynthesis screening and screens falsely recalled in the course of breast tomosynthesis screening, illustrating both true-positive (TP) and false-positive (FP) detection attributed to tomosynthesis. Images and descriptive data were used to characterise cases of screen-detection with tomosynthesis, sourced from prospective screening trials that performed standard (2D) digital mammography (DM) and tomosynthesis (3D-mammography) in the same screening participants. Exemplar cases from four trials highlight common themes of relevance to screening practice including: the type of lesions frequently made more conspicuous or perceptible by tomo...
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSIONS: Most breast cancer histological types have similar SWE characteristics. The exception is tubular cancer which has significantly lower stiffness than other histologic types, accounted for largely by their small size. PMID: 27017250 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100Authors: Rydén L, Heibert Arnlind M, Vitols S, Höistad M, Ahlgren J Abstract Tamoxifen (TAM) and aromatase inhibitors (AI) are adjuvant therapy options for postmenopausal women with estrogen receptor positive (ER+) breast cancer. This systematic review of seven randomized controlled studies comparing TAM and AI, and one study comparing extended therapy with an AI with placebo after about 5 years of tamoxifen, aims to assess long-term clinical efficacy and adverse events. The literature review was performed according to the principles of the Cochrane Collaboration. The search included common databases up to 2013-01-14. Studies of high or moderate quality were used for grading of evidence. Revman™ software was utilized for meta-analyses of published data. Disease free survival (D...
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSIONS: In settings with limited resources, women with high neuroticism or a depression/anxiety treatment history should be the initial target of psychological screening. Identification of women with these characteristics at the earliest point of entry into the oncology service followed by heightened surveillance and/or referral to psychosocial services may be useful to prevent chronic psychological morbidity. PMID: 27017248 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100Authors: Paluch-Shimon S, Pagani O, Partridge AH, Bar-Meir E, Fallowfield L, Fenlon D, Friedman E, Gelmon K, Gentilini O, Geraghty J, Harbeck N, Higgins S, Loibl S, Moser E, Peccatori F, Raanani H, Kaufman B, Cardoso F Abstract The 2nd International Consensus Conference for Breast Cancer in Young Women (BCY2) took place in November 2014, in Dublin, Ireland organized by the European School of Oncology (ESO). Consensus recommendations for the management of breast cancer in young women (BCYW) were updated from BCY1 with incorporation of new evidence to inform the guidelines, and areas of research priorities were identified. This manuscript summarizes these international consensus recommendations, which are also endorsed by the European Society of Breast Specialists (EUSOMA). PMID:...
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSION: Quality of preoperative diagnostics play a crucial role in minimizing the need of repeated imaging and biopsies as well as multiple operations. Positive impact of high-volume hospitals becomes evident when analyzing procedures requiring advanced surgical techniques. High-volume hospitals achieved better quality in axillary surgery. PMID: 27017246 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSIONS: SR is a reliable method for predicting free surgical margins in non-invasive breast cancer where a minimum radiological free margin of 4 Fmm is achieved. However, histological DCIS size remains the most important factor determining successful BCT. PMID: 27017245 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSION: The DIEAP flap is an excellent option for breast reconstruction, with a low level of donor site morbidity and complications. It is an autologous reconstruction that provides a stable long term result. PMID: 27017243 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100We describe a breast cancer patient with HER-2 positive leptomeningeal disease in the spinal cord successfully treated with intrathecal trastuzumab and methotrexate, alongside systemic anti-HER-2 therapy and radiotherapy. We also review the literature to date on the efficacy and safety of intrathecal trastuzumab, and recent evidence suggesting that intrathecal trastuzumab passes via the blood brain barrier into the serum to achieve intravenous concentrations similar to that seen with systemic therapy alone. Overall, intrathecal trastuzumab appears to be a safe and often effective treatment for leptomeningeal metastases in HER-2 positive breast cancer. Ongoing phase I and II studies are required to determine optimum dosing schedules, validate CSF and CSF-to-serum pharmacokinetics, determine...
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSIONS: Results orientate towards good patients' adaptation to their disease and treatments, and to administering RT in early stages breast cancer patients. QL differences between the axillary surgery groups and in their evolutions were few but have appeared in key QL areas. PMID: 27017241 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100Authors: Nicholas Zdenkowski, Butow P, Tesson S, Boyle F Abstract Several complex treatment decisions may be offered to women with early stage breast cancer, about a range of treatments from different modalities including surgery, radiotherapy, and endocrine and chemotherapy. Decision aids can facilitate shared decision-making and improve decision-related outcomes. We aimed to systematically identify, describe and appraise the literature on treatment decision aids for women with early breast cancer, synthesise the data and identify breast cancer decisions that lack a decision aid. A prospectively developed search strategy was applied to MEDLINE, the Cochrane databases, EMBASE, PsycINFO, Web of Science and abstract databases from major conferences. Data were extracted into a pre-pil...
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSIONS: A significant association was found between seroma and late-adverse effects after radiotherapy although no significant associations were noted with breast composition in this study. Therefore, the cause for large breast size as a risk factor for late effects after surgery and optimally planned radiotherapy remains unresolved. PMID: 27017239 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSION: FBC subtypes do not give the same prognostic information in MBC even in luminal groups. Two subgroups with distinct prognosis were identified in a common six-IHQ panel. Future studies must achieve their real prognostic value in these patients. PMID: 27017238 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSIONS: SBRT is a safe and feasible alternative treatment of liver and lung oligometastases from breast cancer, in selected patients not amenable to surgery, with good local control and survival rate. PMID: 27017237 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:23:02 +0100CONCLUSION: We developed a new systematic analytic method for analyzing TCGA database, which took into account both miRNA and mRNA data to dissect the miRNA regulation network in BRCA. PMID: 27017236 [PubMed - as supplied by publisher] (Source: Breast)
Mon, 28 Mar 2016 21:22:13 +0100Adalis Martinez was diagnosed with colon cancer the week of her college graduation; faith and her loved ones helped her get through it (Source: Health News: CBSNews.com)
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSION: Although SNaPshot can identify potentially important therapeutic targets, the incidence of 'drugable' targets in ovarian cancer is low. In this cohort, only 7% of subjects eventually were treated on a relevant clinical trial. Geneotyping should be used judiciously and reflect histologic subtype and available platform. PMID: 27016236 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSIONS: A significant proportion of our cohort harbor germline mutations in DNA repair genes. This may be associated with the high rate of breast cancer in our patients and their family, and suggests a targeted cohort for genetic counseling. If validated in a larger cohort, our findings may allow clinicians to expand therapeutic options to include targeted therapies and inclusion of USC patient in preventative and genetic counseling. PMID: 27016235 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSIONS: Using transcriptional profiling the current study suggests that HGCCOCs and HGEOCs of advanced stage group together with HGSOCs. However, HGCCOCs and HGEOCs of early disease stages may have distinct transcriptional signatures similar to those seen in their low grade counterparts. PMID: 27016234 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:57:02 +0100Authors: Zamarin D, Jazaeri AA Abstract During the past decade significant progress in the understanding of stimulatory and inhibitory signaling pathways in immune cells has reinvigorated the field of immuno-oncology. In this review we outline the current immunotherapy based approaches for the treatment of gynecological cancers, and focus on the emerging clinical data on immune checkpoint inhibitors, adoptive cell therapies, and vaccines. It is anticipated that in the coming years biomarker-guided clinical trials, will provide for a better understanding of the mechanisms of response and resistance to immunotherapy, and guide combination treatment strategies that will extend the benefit from immunotherapy to patients with gynecologic cancers. PMID: 27016233 [PubMed - in process...
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSION: FFA-induced cancer cell growth may be partly mediated through FFAR1/GPR40. Targeting of FFAR1/GPR40 may be an attractive treatment strategy in EOC, and possibly offers a targeted treatment for a subset of EOC patients. PMID: 27016232 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:57:02 +0100Authors: Liu J, Westin SN Abstract Precision medicine is a rapidly evolving area in the treatment of gynecologic malignancies. Advances in sequencing technology have resulted in an increasing wealth of data regarding the genomic characteristics of ovarian, endometrial, and cervical cancers. These vast new datasets of information have led to novel insights into potential vulnerabilities and therapeutic targets for these cancers. However, unraveling the complex molecular changes within cancer cells to determine how best to attack these targets and to identify effective biomarkers of response remains a significant challenge. In this article, we review the current status of biomarker-driven targeted therapy in gynecologic malignancies. PMID: 27016231 [PubMed - in process] (Source:...
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSION: Our study identified the copy number deletion of RAD50 as a candidate marker for survival and response to PARPis in BRCAwt OvCa tumors. PMID: 27016230 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSIONS: Our proposal and finding of a scoring system that could predict platinum or taxane response could be useful to develop individualized treatments to ovarian cancer. PMID: 27016229 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSIONS: Mutations in AKT1, TSC1 and TSC2 are rare, but may predict clinical benefit from temsirolimus. CTNNB1 mutations were associated with longer PFS on temsirolimus. PMID: 27016228 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSIONS: The predominant function of our PMB is establishment of a forum to enhance research while providing clinical care for refractory malignancies. We have matched patients with specific mutations to ongoing trials and are developing investigator-initiated studies based on trends within genomic profiling results. Longer-term follow up will be required to determine the success of this strategy. PMID: 27016225 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:57:02 +0100Use of "big data" in drug discovery and clinical trials. Gynecol Oncol. 2016 Apr;141(1):17-23 Authors: Taglang G, Jackson DB Abstract Oncology is undergoing a data-driven metamorphosis. Armed with new and ever more efficient molecular and information technologies, we have entered an era where data is helping us spearhead the fight against cancer. This technology driven data explosion, often referred to as "big data", is not only expediting biomedical discovery, but it is also rapidly transforming the practice of oncology into an information science. This evolution is critical, as results to-date have revealed the immense complexity and genetic heterogeneity of patients and their tumors, a sobering reminder of the challenge facing every patient and their oncologist. Thi...
Mon, 28 Mar 2016 20:57:02 +0100Authors: Randall LM, Pothuri B Abstract Salient to the intent of personalized medicine, hereditary cancer syndromes present significant opportunities in the treatment and prevention of some gynecologic cancers. Mutations in BRCA1, BRCA2, and DNA mismatch repair genes: MLH1, MSH2, MSH6, and PMS2 are important causal agents in hereditary breast and ovarian cancer (HBOC) and Lynch syndromes. Though they only account for an estimated 10-18% of ovarian, tubal, peritoneal, and endometrial cancer cases, inherited cancers are imminently preventable if mutation carriers are identified in a timely manner. Population level screening is currently impractical due to low prevalence of disease, cost of testing, and ethical issues associated with testing, so diagnosis of these mutations is limited...
Mon, 28 Mar 2016 20:57:02 +0100CONCLUSION: These data suggest that an institutional MTB is a feasible venue for reviewing tumor genomic profiling results and generating clinical recommendations. These data also support the need for further studies and guidelines on clinical decision making with greater availability of broad genomically based diagnostics. PMID: 27016222 [PubMed - in process] (Source: Gynecologic Oncology)
Mon, 28 Mar 2016 20:17:30 +0100(Reuters Health) - Acupuncture may help ease hot flashes in women with breast cancer who often can't take traditional hormone treatments, according to a new study from Italy. (Source: Reuters: Health)
Mon, 28 Mar 2016 20:00:00 +0100Italian trial finds the therapy was also linked to better quality of life among women in the study (Source: U.S. News - Health)
Mon, 28 Mar 2016 19:45:00 +0100Today, the Boston Globe editorial board spoke out against a bill "that would require insurers in Massachusetts to cover Lyme disease treatments for as long as a doctor says they're needed." The Globe writes: Lawmakers may have good intentions, but they don't possess the expertise to decide whether it's beneficial, cost-efficient, or safe, to keep using strong medicines to treat a condition the medical establishment doubts is real. Such questions should be resolved by a consensus of doctors and researchers -- and buttressed by convincing clinical date [sic] -- not determined by legislative mandate. Who among the Boston Globe editorial board possesses the medical expertise to make this call is not disclosed, but this information would be useful given that the Globe's stance presumes absolute...