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MedWorm: Adenocarcinoma



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Adenocarcinoma category.



Last Build Date: Tue, 29 Mar 2016 16:50:34 +0100

 



[Oncogenic drivers in daily practice improve overall survival in patients with lung adenocarcinoma].

Tue, 29 Mar 2016 01:52:02 +0100

CONCLUSION: An actionable oncodriver was routinely detected in nearly half of patients with advanced lung adenocarcinoma. This systematic detection may influence treatment outcomes, notably with matched targeted therapy. PMID: 27017063 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)

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Clinicopathologic and prognostic associations of KRAS and BRAF mutations in small intestinal adenocarcinoma

Mon, 28 Mar 2016 22:00:00 +0100

Authors: Sun-Young Jun, Misung Kim, Mi Jin Gu, Young Kyung Bae, Hee-Kyung Chang, Eun Sun Jung, Kee-Taek Jang, Jihun Kim, Eunsil Yu, Dae Woon Eom & Seung-Mo Hong (Source: Modern Pathology)



Histological Subtype and Systemic Metastases Strongly Influence Treatment and Survival in Patients with Synchronous Colorectal Peritoneal Metastases

Mon, 28 Mar 2016 22:00:00 +0100

Conclusions Histological subtype and the presence of systemic metastases strongly influenced treatment choice and survival in patients with synchronous colorectal PM. These results can be used to optimize treatment strategy for patients with synchronous colorectal PM. (Source: European Journal of Surgical Oncology (EJSO))



New pattern-based personalized risk stratification system for endocervical adenocarcinoma with important clinical implications and surgical outcome.

Mon, 28 Mar 2016 20:57:02 +0100

We present a recently introduced three tier pattern-based histopathologic system to stratify endocervical adenocarcinoma (EAC) that better correlates with lymph node (LN) metastases than FIGO staging alone, and has the advantage of safely predicting node-negative disease in a large proportion of EAC patients. The system consists of stratifying EAC into one of three patterns: pattern A tumors characterized by well-demarcated glands frequently forming clusters or groups with relative lobular architecture and lacking destructive stromal invasion or lymphovascular invasion (LVI), pattern B tumors demonstrating localized destructive invasion (small clusters or individual tumor cells within desmoplastic stroma often arising from pattern A glands), and pattern C tumors with diffusely infiltrative...



Mp45-18 a potential role for 6-sulfo sialyl lewisx in metastasis of bladder urothelial carcinoma

Mon, 28 Mar 2016 19:24:10 +0100

It is widely accepted that sialyl Lewis X(sLeX) and sialyl Lewis A(sLeA, also known as CA19-9) glycans expressed on cancer cells function in E-selectin-mediated metastasis. Recently, it was reported that 6-sulfo sLeX glycans detected by the MECA-79 monoclonal antibody are expressed in roughly a quarter of gastric adenocarcinoma cases, and that these cases show a poorer prognosis than MECA-79-negative cases do. The present study was undertaken to assess expression of 6-sulfo sLeX glycans in bladder urothelial carcinoma and evaluate potential clinical implications. (Source: The Journal of Urology)



V5-06 initial experience during development of laparoscopic 12mm hifu probe

Mon, 28 Mar 2016 19:24:10 +0100

We present our initial experience with this emerging technology. (Source: The Journal of Urology)

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Mp62-18 conversion of adenocarcinoma to small cell carcinoma-like by reprogramming

Mon, 28 Mar 2016 19:24:08 +0100

Most prostate tumors are adenocarcinoma with glandular differentiation, and a small percentage, found most frequently in advanced diseases, are small cell neuroendocrine carcinoma without glandular differentiation. The LuCaP series is a family of prostate cancer xenografts propagated in male mice. LuCaP CR variants were obtained from passages in castrated hosts. Expression of stem cell transcription factor (TF) genes LIN28A, NANOG, POU5F1, SOX2 was examined in the LuCaP lines because some LuCaP lines were found to express stem cell markers. (Source: The Journal of Urology)



Pd33-04 pathological characteristics and prognostic indicators of different histopathological types following radical cystectomy: a large cohort with long-term follow-up

Mon, 28 Mar 2016 19:24:08 +0100

Pathological features and prognostics are better characterized for urothelial cancer (UC) compared to other histological types. Herein we determined differences in pathological features and prognostics among 4 different histological types: UC, UC with metaplasia (UCM), squamous cell carcinoma (SCC) and adenocarcinoma (ADC) utilizing a large cohort of radical cystectomy (RC) patients with long term follow up. (Source: The Journal of Urology)



Mp66-03 the chromatin associated sin3b protein restricts prostate cancer progression.

Mon, 28 Mar 2016 19:24:06 +0100

While prostate adenocarcinoma remains the most common cancer in the USA, only a discrete proportion of prostate lesions progresses to invasive adenocarcinoma. Therefore, defining the molecular determinants that restrict prostate cancer progression represents a priority for accurate identification of patients in need of treatment. Clinical monitoring of prostate cancer currently relies on histo-pathological and chemical indicators, which include Gleason scoring and PSA levels. Unfortunately, the use of these parameters in order to manage prostate cancer treatment has proven largely inadequate in the recent years. (Source: The Journal of Urology)



Mp02-13 microrna expression profiling of prostate tissue suggests mir-509-3p as a diagnostic marker for prostatic adenocarcinoma

Mon, 28 Mar 2016 19:24:04 +0100

MicroRNAs (miRs) are short noncoding RNAs that regulate cell proliferation and apoptosis. Their role in cancer development and progression is being widely researched. Our objective was to identify miRs that are differentially expressed to a high degree between prostatic adenocarcinoma and normal prostate for diagnostic use. (Source: The Journal of Urology)



V4-01 our successful experience utilizing posterior rhabdosphincter reconstruction during robotic prostatectomy

Mon, 28 Mar 2016 19:24:04 +0100

There have been numerous techniques employed to maximize continence after robot-assisted radical prostatectomy (RARP), including posterior rhabdosphincter reconstruction (PRR). However optimum PRR stitch location remains relatively undefined. We aimed to apply our modified posterior reconstruction of the rhabdosphincter (M-PRR) in 570 consecutive patients undergoing RARP for adenocarcinoma of the prostate. In this video, we demonstrate our technique for M-PRR performed during RARP. (Source: The Journal of Urology)

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Pd43-07 upstaging on final pathology in patients eligible for active surveillance with subdivision by age

Mon, 28 Mar 2016 19:24:04 +0100

Active surveillance (AS) has become increasingly utilized and has gained acceptance for the management of men with localized prostate cancer who have low risk clinical features. Our goal was to analyze the preoperative data in men with adenocarcinoma of the prostate and compare this with post prostatectomy specimens in patients who were eligible for AS but chose to undergo robotic-assisted radical prostatectomy (RARP). We also subdivided our data into age categories to assess for a difference. (Source: The Journal of Urology)



Mp84-10 erg induces endoplasmic reticulum stress (er) and unfolded protein response (upr) to initiate prostate cancer carcinogenesis

Mon, 28 Mar 2016 19:24:03 +0100

High levels of the ERG expression due to gene fusions (predominantly TMPRSS2-ERG) is frequently detected in prostate cancer (CaP) in Western countries. Better understanding of the roles of the ERG oncogenic functions in CaP initiation and/or progression will enhance its utility as the therapeutic target. Transgenic mice generated to understand ERG’s role in the development of prostate adenocarcinoma have shown focal proliferative and dysplastic PIN lesions and later developed adenocarcinoma in older mice. (Source: The Journal of Urology)



Mp07-20 development and validation of genomic signature that predicts adt treatment failure

Mon, 28 Mar 2016 19:24:03 +0100

Androgen deprivation therapy (ADT) is one of the main treatment options for locally advanced, recurrent and metastatic prostate cancer. Neuroendocrine prostate cancer (NEPC) is inherently less sensitive or even resistant to ADT. NEPC can be observed de novo (e.g., small cell prostate cancer) but more commonly arises after exposure to ADT. In some patients, even short exposure to ADT may “unmask” a NEPC phenotype. We hypothesized that a gene expression signature of NEPC when measured in primary tumor specimens (RP) of prostatic adenocarcinoma may be useful for predicting patients with innate resistance to ADT. (Source: The Journal of Urology)



Mp06-14 adenocarcinoma of the bladder: pathologic characteristics, trends in management, and survival

Mon, 28 Mar 2016 19:24:03 +0100

Adenocarcinoma of the bladder is a rare variant histology of cancer comprising less than 2% of all bladder malignancies. We assessed patient characteristics and outcomes for those undergoing definitive management of localized clinical disease. (Source: The Journal of Urology)



Mp88-13 mutational landscape of primary bladder and urachal adenocarcinoma

Mon, 28 Mar 2016 19:24:02 +0100

Adenocarcinomas of the bladder and urachus represent a rare subtype of urinary tract cancer and account for 2% of all tumors originating from the bladder. Localized disease can be managed with surgical extirpation alone; however, less than 40% of patients with advanced disease will achieve an objective response with platinum-based chemotherapy. We hypothesized that bladder and urachal adenocarcinomas harbor a distinct mutational profile that may make them susceptible to targeted agents. (Source: The Journal of Urology)

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Mp09-07 risk of lymph node metastases in pathological gleason score =6 prostate adenocarcinoma: analysis of institutional and population-based databases

Mon, 28 Mar 2016 19:24:02 +0100

To evaluate the incidence of lymph node metastases (LNM) in pathological Gleason score =6 prostate cancer (PCa) using data generated by the Surveillance, Epidemiology, and End Results (SEER) database, the National Cancer Database (NCDB), and an institutional database at the University of Chicago Medical Center (UCMC). (Source: The Journal of Urology)



Correlation between histological invasiveness and the computed tomography value in pure ground-glass nodules

Mon, 28 Mar 2016 18:37:21 +0100

Conclusion Pure GGNs with a maximum diameter of ≤10 mm and CT value of ≤−600 HU are nearly always pre-invasive lesions; therefore, surgery should be carefully selected in such patients. (Source: Surgery Today)



Preoperative independent prognostic factors in patients with borderline resectable pancreatic ductal adenocarcinoma following curative resection: the neutrophil-lymphocyte and platelet-lymphocyte ratios

Mon, 28 Mar 2016 18:37:21 +0100

Conclusions Higher preoperative NLR and PLR can be independent predictive risk factors in BR-PDAC patients following curative resection. (Source: Surgery Today)



Treatment of Uterine Carcinomas

Mon, 28 Mar 2016 12:30:44 +0100

Uterine epithelial cancers are the most common type of gynecologic cancer in the United States. The American Cancer Society estimated 53,000 new cases of uterine cancers in 2014 with 8,600 deaths from advanced or recurrent cases, 99% of which are endometrial cancer. The 5-year survival rate of low-stage, low-grade endometrioid adenocarcinoma is greater than 90%. In contrast, advanced stage endometrioid adenocarcinomas and Type II (serous and carcinosarcoma) endometrial cancers have a much poorer prognosis, with the 5-year survival rate of advanced stage uterine carcinosarcoma as low as 9%. Together, these endometrial cancers with poor prognoses comprise almost half of all cases in the US, creating a significant medical obstacle for management. The authors present a review of endometrial ca...



Primary Multifocal Malignant Melanoma of Esophagus Co-Occurs With Esophagogastric Junction Adenocarcinoma

Sun, 27 Mar 2016 22:00:00 +0100

Authors: Yu-Bin Zhou, Yong Yuan, Bing Hu & Guo-Wei Che (Source: The American Journal of Gastroenterology)

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Role of the TNF‐α receptor type 1 on prostate carcinogenesis in knockout mice

Sun, 27 Mar 2016 22:00:00 +0100

CONCLUSIONSTNF‐α, through its receptor TNFR‐1, promoted cell proliferation and cell survival in prostate by activation of the AKT/mTOR and NFKB pathway, which stimulated prostate carcinogenesis in chemically induced mice. Prostate © 2016 Wiley Periodicals, Inc. (Source: The Prostate)



Intranasal Administration of Type V Collagen Reduces Lung Carcinogenesis through Increasing Endothelial and Epithelial Apoptosis in a Urethane-Induced Lung Tumor Model

Sun, 27 Mar 2016 22:00:00 +0100

In this study, we have extended our investigation with the aim to obtain further evidence that the death induced by Col V-treatment is of the caspase-9 apoptotic type. We used (1) optical and electron microscopy, (2) quantitation of TUNEL-labeled cells and (3) analysis of the expression levels of Col V and selected genes coding for apoptosis-linked factors, by conventional RT-PCR. BALB/c mice were injected intraperitoneally with 1.5 g/kg body weight of urethane. After urethane injection, the animals received intranasal administration of 20 µg/20 µl of Col V every day during 2 months. We report here that Col V treatment was able to determine significant increase in Col V protein and gene expression and in the percentage of TUNEL-positive cells, to up-regulate caspase-9, resulting in l...



Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma

Sun, 27 Mar 2016 22:00:00 +0100

Discussion Our results establish an association of TILs and survival in OAC, as seen in other solid tumours, and identify particular TIL subsets that are present at higher levels in patients who responded to NAC compared to non-responders. These findings highlight potential therapeutic strategies in EAC based on utilising the host immunological response and highlight the immune responses biomarker potential. (Source: Cancer Immunology, Immunotherapy)



About thymic carcinomas: challenges in diagnosis and management

Sun, 27 Mar 2016 22:00:00 +0100

Conclusion In spite of the lack of follow-up information, this study demonstrates the poor outcome associated with these tumors and the need for standardized treatment. (Source: Asian Cardiovascular and Thoracic Annals)



Massive malignant pleural effusion due to lung adenocarcinoma in 13-year-old boy

Sun, 27 Mar 2016 22:00:00 +0100

A 13-year-old boy with no risk factors for lung cancer presented with a massive left-sided pleural effusion and a mediastinal shift on chest radiography and computed tomography. A chest tube drained bloody pleural fluid with an exudative pattern. A pleural biopsy and wedge biopsy of the left lower lobe revealed mucinous adenocarcinoma in the left lower lobe wedge biopsy and metastatic adenocarcinoma in the pleural biopsy. The patient is currently undergoing chemotherapy. Radiotherapy is planned after shrinkage of the tumor. Adenocarcinoma of the lung is very rarely seen in teenagers or children, especially in the absence of risk factors. (Source: Asian Cardiovascular and Thoracic Annals)

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Palliative Management of Unresectable Pancreas Cancer.

Sun, 27 Mar 2016 21:38:02 +0100

This article reviews the palliative management of unresectable pancreatic cancer, including potential palliative resection, surgical and endoscopic biliary and gastric decompression, and pain control with celiac plexus block. PMID: 27013367 [PubMed - in process] (Source: The Surgical Clinics of North America)



Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma.

Sun, 27 Mar 2016 05:28:02 +0100

In conclusion, this study showed that HH pathway is a survival signaling that drives LAC cell growth under stress conditions, and HHIP is a key regulator to block the induction of HH pathway. Targeting the HH pathway through inhibitors or HHIP thus holds promise to address EGFR-TKI resistance in LAC in clinic. PMID: 27015549 [PubMed - as supplied by publisher] (Source: Oncotarget)



Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Shen JX, Liu J, Li GW, Huang YT, Wu HT Abstract Aldehyde dehydrogenase 1 (ALDH1) consists of a family of intracellular enzymes, highly expressed in stem cells populations of leukemia and some solid tumors. Up to now, 6 isoforms of ALDH1 have been reported. However, the expression patterns and the identity of ALDH1 isoenzymes contributing to ALDH1 activity, as well as the prognostic values of ALDH1 isoenzymes in cancers all remain to be elucidated. Here, we studied the expressions of ALDH1 transcripts in gastric cancer (GC) compared with the normal controls using the ONCOMINE database. Through the Kaplan-Meier plotter database, which contains updated gene expression data and survival information of 876 GC patients, we also investigated the prognostic values of ALDH1 isoenzy...



miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Chen QY, Jiao DM, Wang J, Hu H, Tang X, Chen J, Mou H, Lu W Abstract MicroRNAs (miRNAs) play a critical role in drug resistance and epithelial-mesenchymal transition (EMT). The aims of this study were to explore the potential role of miR-206 in governing cisplatin resistance and EMT in lung cancer cells. We found that both lung adenocarcinoma A549 cisplatin-resistant cells (A549/DDP) and H1299 cisplatin-resistant cells (H1299/DDP) acquired mesenchymal features and were along with low expression of miR-206 and high migration and invasion abilities. Ectopic expression of miR-206 mimics inhibited cisplatin resistance, reversed the EMT phenotype, decreased the migration and invasion in these DDP-resistant cells. In contrast, miR-206 inhibitors increased cisplatin resistance, E...



Analysis of mutational and clinicopathologic characteristics of lung adenocarcinoma with clear cell component.

Sun, 27 Mar 2016 05:28:02 +0100

CONCLUSIONS: Lung adenocarcinoma with clear cell component is a rare, malignant tumor with poor prognosis and displays more frequent EGFR and KRAS mutations. PMID: 27013585 [PubMed - as supplied by publisher] (Source: Oncotarget)

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Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells.

Sun, 27 Mar 2016 05:28:02 +0100

In this study, In Silico Analysis using Oncomine and Kaplan Meier plotter revealed that FADD is significantly up-regulated in breast cancer tissues and closely associated with a poor prognosis in patients with breast cancer. To better understanding the FADD functions in breast cancer, we performed proteomics analysis by LC-MS/MS detection and found that Rheb-mTORC1 pathway was dysregulated in MCF-7 cells when FADD knockdown. The mTORC1 pathway is a key regulator in many processes, including cell growth, metabolism and autophagy. Here, FADD interference down-regulated Rheb expression and repressed mTORC1 activity in breast cancer cell lines. The autophagy was induced by FADD deficiency in MCF7 or MDA-231 cells but rescued by recovering Rheb expression. Similarly, growth defect in FADD-knock...



Isolation and identification of oxygenated lanostane-type triterpenoids from the fungus Ganoderma lucidum

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Xi-Run Zhao, Bao-Jing Zhang, Sa Deng, Hou-Li Zhang, Shan-Shan Huang, Xiao-Kui Huo, Chao Wang, Fang Liu, Xiao-Chi Ma Ganoderma lucidum is widely used throughout the world as a form of traditional medicine. Phytochemical investigation of the chloroform (CHCl3) extract of the fruiting body of G. lucidum resulted in the isolation of four lanostane-type triterpenoids. Based on various spectroscopic data, the isolated triterpenoids were identified as highly oxygenated lanostane-type triterpenoids, including four new compounds (1–4). Furthermore, in vitro bioassays using an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and measuring the nitric oxide production in LPS-stimula...



A case of adenocarcinoma with enteroblastic differentiation of the ampulla of Vater

Sat, 26 Mar 2016 23:00:00 +0100

Cancer of the ampulla of Vater is rare, though it has various histological types and its histogenesis is fascinating in view of the anatomically complex nature of the ampulla. Fetal gut‐like adenocarcinoma, usually found in the stomach, can also develop in the ampullary region in extremely rare cases. Here we present a case of ampullary adenocarcinoma with enteroblastic and neuroendocrine differentiation. A 55‐year‐old woman presented with an epigastric pain. Endoscopic examination revealed a 2‐cm submucosal tumor‐like lesion in the ampulla. The surgical specimen showed that an exposed protruding type of tumor appeared as a well‐demarcated whitish‐yellow solid mass. Microscopically, the tumor had proliferated in the common channel and invaded the duodenal submucosa with mucos...



Single-port video-assisted thoracic surgery for early lung cancer: initial experience in Japan.

Sat, 26 Mar 2016 22:10:02 +0100

CONCLUSIONS: SPVATS is a safe and feasible technique, and is promising for next-generation thoracoscopic surgery. It may also reduce postoperative wound pain and contribute to improvements in the activities of daily living of patients. PMID: 27014483 [PubMed] (Source: Journal of Thoracic Disease)



Nonintubated uniportal thoracoscopic surgery for resection of lung lesions.

Sat, 26 Mar 2016 22:10:02 +0100

CONCLUSIONS: Nonintubated uniportal VATS is technically feasible, effective, and safe for diagnosis and treatment of various lung lesions in selected patients. PMID: 27014470 [PubMed] (Source: Journal of Thoracic Disease)

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Metastatic Genital Tract Adenocarcinoma to the Vulva: A Rare Occurrence Presenting as Painful Vulvar Enlargement

Sat, 26 Mar 2016 08:13:16 +0100

No abstract available (Source: Journal of Lower Genital Tract Disease)



A case of acquired angioedema possibly associated with adenocarcinoma of the colon

Fri, 25 Mar 2016 23:00:00 +0100

Acquired angioedema (AAE) is an uncommon condition characterized by angioedema without wheals associated with low C1 inhibitor, C4, and C1q levels secondary to disproportionate activation or depletion of C1 esterase inhibitor (C1INH). First described by Caldwell et al1 in 1972, AAE is clinically indistinguishable from hereditary angioedema (HAE) and leads to unpredictable angioedema episodes that last 2 to 5 days. AAE is most commonly due to lymphoproliferative disorders.2 Less common causes include solid organ tumors, infection, and systemic lupus erythematosus. (Source: Annals of Allergy, Asthma and Immunology)



Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21.

Fri, 25 Mar 2016 20:54:02 +0100

CONCLUSIONS: Patients with EGFR 19 del exhibit longer PFS and higher ORR compared with those with L858R mutations. Whether the heterogeneity of tumors with EGFR 19 del and L858R mutations contribute to a therapeutic response difference needs further investigation. PMID: 27001083 [PubMed - in process] (Source: Chinese Journal of Cancer)



The role of the tissue plasminogen activator as a prognostic and differentiation factor in patients with pancreatic canceer and chronic pancreatitis.

Fri, 25 Mar 2016 19:51:02 +0100

Authors: Baluka D, Urbanek T, Lekstan A, Swietochowska E, Wiaderkiewicz R, Kajor M, Jedrzejewska-Szypulka H, Kusnierz K, Lampe P Abstract Unsatisfactory pancreatic cancer treatment outcomes have prompted multiple avenues of research focused on identifying not only biomarkers of pancreatic adenocarcinoma progression but also potential prognostic survival factors in patients with pancreatic adenocarcinoma. Study consisted of 75 patients who underwent pancreatic resections between 2006 and 2011: 35 patients with pancreatic ductal adenocarcinoma (PC), 30 patients with chronic pancreatitis (CP), and a non-malignant control group (NMCG) of 10 patients who underwent surgery due to benign tumors. Tissue plasminogen activator (t-PA) concentrations in tissue homogenates and sera were evaluat...



Analysis of ultra-deep targeted sequencing reveals mutation burden is associated with gender and clinical outcome in lung adenocarcinoma.

Fri, 25 Mar 2016 17:33:04 +0100

In this study we evaluated the clinical significance of mutation burden in lung adenocarcinoma and found that the male tumors harbored statistically greater burden of genetic alterations than female counterparts (Male median 3 (range 0-34) vs female median = 2 (0-24), male to female ratio = 1.636, 95% CI = 1.343-1.992) after adjustment of age at surgery, stage, smoking status. Kaplan-Meier survival analysis revealed that greater burden of genetic alterations was associated with worse overall survival. Moreover, multivariable analysis demonstrated mutation burden was an independent prognostic factor for the patients. Taken together, our analysis demonstrated gender disparity of mutation burden and their prognostic value in lung adenocarcinoma. This gender difference in mutation burden might...

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Decreased level of RASSF6 in sporadic colorectal cancer and its anti-tumor effects both in vitro and in vivo.

Fri, 25 Mar 2016 17:33:04 +0100

In this study, we demonstrate that RASSF6 acts as a tumor suppressor in colon cancer cells. Decreased level of RASSF6 was observed in adenocarcinoma compared to normal tissues, especially in advanced tumor cases. Further experiments showed exogenous introduction of RASSF6 into LoVo cells suppressed cell proliferation, migration, invasion, and induced apoptosis in vitro as well as tumor growth in vivo. In contrast, knockdown of RASSF6 in HT-29 cells showed the opposite effects. Taken together, our results suggest, in addition to epigenetics changes, functional somatic mutations may also contribute to the downregulation of RASSF6 and further participate in the pathogenesis of sCRC. RASSF6 may serve as a novel candidate against tumor growth for sCRC. PMID: 27009808 [PubMed - as supplied b...



Toll-like receptors 1, 2, 4 and 6 in esophageal epithelium, Barrett's esophagus, dysplasia and adenocarcinoma.

Fri, 25 Mar 2016 17:33:04 +0100

CONCLUSIONS: TLR1, TLR2, TLR4 and TLR6 are upregulated during malignant changes of esophageal columnar epithelium. Increased TLR4 expression associates with advanced stage and poor prognosis in esophageal adenocarcinoma. PMID: 27008696 [PubMed - as supplied by publisher] (Source: Oncotarget)



Neutrophil Gelatinase-Associated Lipocalin (NGAL) concentration in urine is superior to CA19-9 and Ca 125 in differentiation of pancreatic mass. Preliminary report.

Fri, 25 Mar 2016 15:40:03 +0100

CONCLUSIONS: In conclusion, NGAL in urine and bile are remarkably accurate in differentiating pancreatic mass due to chronic pancreatitis from pancreatic adenocarcinoma. Therefore, NGAL concentrations in bile and urine should be further investigated in order to assess their usefulness in early pancreatic adenocarcinoma diagnosis. PMID: 27002756 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)



Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome‐wide shRNA screen

Fri, 25 Mar 2016 09:08:35 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



Prostate cancer: from Gleason scoring to prognostic grade grouping.

Fri, 25 Mar 2016 07:45:02 +0100

Authors: Montironi R, Santoni M, Mazzucchelli R, Burattini L, Berardi R, Galosi AB, Cheng L, Lopez-Beltran A, Briganti A, Montorsi F, Scarpelli M Abstract The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to prognosis, the application of the Gleason grading system changed substantially in surgical pathology. First in 2005 and more recently in 2014, consensus conferences were held to update PAC grading. Here, we review of the successive changes in the grading of PAC from the original system, with emphasis on the newest pr...

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[Report] Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Thu, 24 Mar 2016 23:00:00 +0100

As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intratumor heterogeneity (ITH) on antitumor immunity. Through integrated analysis of ITH and neoantigen burden, we demonstrate a relationship between clonal neoantigen burden and overall survival in primary lung adenocarcinomas. CD8+ tumor-infiltrating lymphocytes reactive to clonal neoantigens were identified in early-stage non–small cell lung cancer and expressed high levels of PD-1. Sensitivity to PD-1 and CTLA-4 blockade in patients with advanced NSCLC and melanoma was enhanced in tumors enriched for clonal neoantigens. T cells recognizing clonal neoantigens were detectable in patients with durable clini...



Anti-proliferative activity of novel 4H-benzo[h]chromenes, 7H-benzo[h]-chromeno[2,3-d]pyrimidines and the structure–activity relationships of the 2-, 3-positions and fused rings at the 2, 3-positions

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: Available online 19 March 2016 Source:Journal of Saudi Chemical Society Author(s): Ahmed M. El-Agrody, Ahmed H. Halawa, Ahmed M. Fouda, Al-Anood M. Al-Dies In the present study, novel derivatives of 4H-benzo[h]chromene and 7H-benzo[h]chromeno[2,3-d]pyrimidine were prepared and evaluated for their anti-proliferative activity against three human tumor cell lines breast adenocarcinoma (MCF-7), human colon carcinoma (HCT-116) and hepatocellular carcinoma (HepG-2) in comparison with the standard drugs Doxorubicin, Vinblastine and Colchicine using MTT colorimetric assay. The structures of the target compounds were established on the basis of spectral data. We explored the Structure–Activity Relationship (SAR) of 4H-benzo[h]chromenes with modification at the 2- or 3- and...



Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial–mesenchymal transition phenotype

Thu, 24 Mar 2016 23:00:00 +0100

Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial–mesenchymal transition phenotype Laboratory Investigation 96, 391 (April 2016). doi:10.1038/labinvest.2015.155 Authors: Yuji Sakuma, Hirotaka Nishikiori, Sachie Hirai, Miki Yamaguchi, Gen Yamada, Atsushi Watanabe, Tadashi Hasegawa, Takashi Kojima, Toshiro Niki & Hiroki Takahashi (Source: Laboratory Investigation)






Merrimack Announces Inclusion of ONIVYDE(R) (irinotecan liposome injection) as a Category 1 Treatment Option in the 2016 NCCN Guidelines for Pancreatic Adenocarcinoma

Thu, 24 Mar 2016 15:23:19 +0100

Updated guidelines recognize the ONIVYDE regimen as a standard-of-care for treatment of patients with post-gemcitabine metastatic pancreatic cancer CAMBRIDGE, Mass., March 24, 2016 -- (Healthcare Sales & Marketing Network) -- Merrimack Pharmaceuticals,... Biopharmaceuticals, OncologyMerrimack Pharmaceuticals, ONIVYDE, irinotecan, Pancreatic Cancer, NCCN (Source: HSMN NewsFeed)

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Expression of β-catenin and its correlation with metastatic progression of esophagogastric junction adenocarcinoma.

Thu, 24 Mar 2016 12:58:02 +0100

Authors: Wlodarczyk J, Rudnicka-Sosin L, Kużdżał J Abstract The evaluation of β-catenin expression in adenocarcinoma of the esophagogastric junction and its influence on cancer progression. Sixty-one patients who were diagnosed with adenocarcinoma of the esophagogastric junction were examined. We evaluated β-catenin distribution in the cell membrane and the cell nucleus in adenocarcinoma of the esophagogastric junction type 1 and type 3. Our findings showed lack of a statistically significant difference in evaluation of adenocarcinoma type 1 and type 3 aggressiveness. However, we found a statistically significant association with the T and N stage, although we did not find an effect of them on patient survival. Patients with cellular membrane and cell nucleus staining comprise...



Morphometric differentiation of squamous cell carcinoma and adenocarcinoma of the cervix.

Thu, 24 Mar 2016 12:58:02 +0100

Authors: Wesoła M, Jeleń M Abstract The aim of the study was to define the morphometric characteristics of squamous cell carcinoma (SCC) and adenocarcinoma (AC) cells and identify opportunities to differentiate these tumors based on determination of the morphometric characteristics in order to use the results of research in the diagnosis of cervical cancer. Pap smears with two histopathologically confirmed cervix cancers were used for testing. For the morphometric assessment of cancer cells the dotSlide program was used. The mean nucleus area for AC cells was 126.62 × 10-6 m2, while this value for SCC was 145.07 × 10-6 m2 (p = 0.000132). The mean circumference of AC cells was 42.43 × 10-6 m, while for SCC cells it was 46.67 × 10-6 m (p = 0.00). AC cell diameter was 13.83 µm,...



Tumour suppression: To EMT or not to EMT?

Wed, 23 Mar 2016 23:00:00 +0100

Nature Reviews Cancer 16, 199 (2016). doi:10.1038/nrc.2016.32 Author: Gemma K. Alderton Transforming growth factor-β (TGFβ) signalling can be oncogenic or tumour suppressive. Because SMAD4, a mediator of TGFβ signalling, is frequently inactivated in pancreatic ductal adenocarcinoma (PDAC), David et al. used this cancer type to investigate the dichotomous role of TGFβ in tumorigenesis. In PDAC (Source: Nature Reviews Cancer)



Tigecycline targets non‐small cell lung cancer through inhibition of mitochondrial function

Wed, 23 Mar 2016 23:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)



Asian Consensus on the relationship between Obesity and Gastrointestinal and Liver Diseases

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionThese experts’ consensus on obesity and GI diseases in Asia form the basis for further research, and its translation into addressing this emerging issue. This article is protected by copyright. All rights reserved. (Source: Journal of Gastroenterology and Hepatology)

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KRAS G12D Mutation Subtype Is A Prognostic Factor for Advanced Pancreatic Adenocarcinoma

Wed, 23 Mar 2016 23:00:00 +0100

Authors: Barbara Bournet, Fabrice Muscari, Camille Buscail, Eric Assenat, Marc Barthet, Pascal Hammel, Janick Selves, Rosine Guimbaud, Pierre Cordelier & Louis Buscail (Source: Clinical and Translational Gastroenterology)



Hospital Variation in Anastomotic Leakage After Rectal Cancer Surgery in the Spanish Association of Surgeons Project: The Contribution of Hospital Volume

Wed, 23 Mar 2016 23:00:00 +0100

Conclusion Anastomotic leak varies significantly among hospitals included in the project and this difference cannot be attributed to the annual surgical volume. (Source: Cirugia Espanola)



Lymph node involvement influenced by lung adenocarcinoma subtypes in tumor size ≤3 cm disease: A study of 2268 cases

Wed, 23 Mar 2016 23:00:00 +0100

Conclusion Our study revealed that lung adenocarcinoma subtypes had important role in lymph node involvement for the patients with small-sized lung cancer. (Source: European Journal of Surgical Oncology (EJSO))



HELICOBACTER PYLORI CHRONIC GASTRITIS UPDATED SYDNEY GRADING IN RELATION TO ENDOSCOPICAL FINDINGS AND HELICOBACTER PYLORI IgG- ANTIBODY: DIAGNOSTIC METHODS

Wed, 23 Mar 2016 23:00:00 +0100

Publication date: Available online 24 March 2016 Source:Journal of Microscopy and Ultrastructure Author(s): Taha MM. Hassan, Samia I Al-Najjar, Ibrahim H. Al-Zahrani, Fadi IB. Alanazi, Malek G Alotibi Helicobacter pylori (Hp) inhabits the stomach of more than 50% of humans and has been established as a major etiologic factor in the pathogenesis of chronic gastritis, gastric atrophy, peptic ulcer disease (PUD), gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma (MALTOMA). The aim of this study is to provide an unequivocal information about the Hp-associated gastritis grading according to the Sydney grading system and to compare between the histopathological features with the endoscopical findings and anti-Hp IgG serological status. This analytical study was...



Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma

Wed, 23 Mar 2016 23:00:00 +0100

The incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. Although survival has improved, cure rates remain poor, with <20% of patients surviving 5 years. This is the first study to explore methylome, transcriptome and ENCODE data to characterize the role of methylation in EAC. We investigate the genome-wide methylation profile of 250 samples including 125 EAC, 19 Barrett’s esophagus (BE), 85 squamous esophagus and 21 normal stomach. Transcriptome data of 70 samples (48 EAC, 4 BE and 18 squamous esophagus) were used to identify changes in methylation associated with gene expression. BE and EAC showed similar methylation profiles, which differed from squamous tissue. Hypermethylated sites in EAC and BE were mainly located in CpG-rich promoters. A...

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Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats

Wed, 23 Mar 2016 23:00:00 +0100

This study evaluated whether dietary resistant starch (RS) and green tea extract (GTE), which have anti-inflammatory and anticancer properties, protect against colitis-associated colorectal cancer (CAC) using a rat model, also investigated potential mechanisms of action of these agents including their effects on the gut microbiota. Rats were fed a control diet or diets containing 10% RS, 0.5% GTE or a combination of the two (RS + GTE). CAC was initiated with 2 weekly azoxymethane (AOM) injections (10mg/kg) followed by 2% dextran sodium sulphate in drinking water for 7 days after 2 weeks on diets. Rats were killed 20 weeks after the first AOM. Colon tissues and tumours were examined for histopathology by H&E, gene/protein expression by PCR and immunohistochemistry and digesta for analys...



Skip Neoadjuvant Tx in Node-Negative Esophageal Cancer?Skip Neoadjuvant Tx in Node-Negative Esophageal Cancer?

Wed, 23 Mar 2016 19:17:58 +0100

Patients with clinically staged node-negative esophageal adenocarcinoma derive no overall survival benefit from neoadjuvant chemoradiation, new research hints. Medscape Medical News (Source: Medscape Medical News Headlines)



Mixed adenoneuroendocrine carcinoma (MANEC) of the gastroesophageal junction: a case report and review of the literature.

Wed, 23 Mar 2016 12:43:02 +0100

We present a 57-year-old man admitted to the hospital with nausea and vomiting due to a high-grade malignant mixed adenoneuroendocrine carcinoma of the gastroesophageal junction. The patient underwent Ivor-Lewis esophagectomy and adyuvant chemoradiotherapy. At 8-month follow-up he was alive without evidence of recurrence. PMID: 26999428 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)



Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells.

Wed, 23 Mar 2016 09:24:03 +0100

CONCLUSION: H. pylori-induced activation of NF-κB and AP-1 regulates transcription of oncogenes and mediates hyperproliferation in gastric epithelial cells. PMID: 26996564 [PubMed - in process] (Source: Yonsei Medical Journal)



Isoprenaline Induces Periostin Expression in Gastric Cancer.

Wed, 23 Mar 2016 09:24:03 +0100

CONCLUSION: These findings suggest that the distribution pattern of periostin was broader as the clinical staging of the tumor progressed and found that isoprenaline upregulated expression levels of periostin in gastric cancer cells. PMID: 26996552 [PubMed - in process] (Source: Yonsei Medical Journal)

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Uterine cervical adenocarcinoma metastasizing concurrently to eutopic and ectopic ovaries: A case report

Tue, 22 Mar 2016 23:00:00 +0100

Abstract Ectopic ovary, a designation that includes supernumerary ovaries and accessory ovaries, is a rare gonadal anomaly. We encountered a patient with a metastasis to such an anomaly and herein provide a review of the published work. A 43‐year‐old woman was diagnosed with stage IIb cervical adenocarcinoma with suspicion for a right ovarian malignancy. She underwent laparotomy after completing three cycles of neoadjuvant chemotherapy. Intraoperative inspection revealed two normal ovaries, but an ovary‐like structure was identified attached to the fimbriae of the left fallopian tube. A cystic tumor, 12 cm in diameter, developed from this structure, which was not connected to the infundibulopelvic ligament. The mass was pulled and elevated into the right pelvis by omental adhesions. ...



The Circumferential Resection Margins status: a comparison of Robotic, laparoscopic and open Total Mesorectal Excision for Mid and Low Rectal Cancer

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion Our results suggest that robotic TME has the same oncological short-term results when compared to the open and laparoscopic technique, and it could be safely offered for the treatment of mid and low rectal cancer. (Source: European Journal of Surgical Oncology (EJSO))



Saudi oncology society and Saudi urology association combined clinical management guidelines for prostate cancer

Tue, 22 Mar 2016 23:00:00 +0100

Ashraf Abusamra, Esam Murshid, Hussain Kushi, Sultan Alkhateeb, Mubarak Al-Mansour, Ahmad Saadeddin, Danny Rabah, Shouki Bazarbashi, Mohammed Alotaibi, Abdullah Alghamdi, Khalid Alghamdi, Abdullah Alsharm, Imran AhmadUrology Annals 2016 8(2):123-130This is an update to the previously published Saudi guidelines for the evaluation, medical, and surgical management of patients diagnosed with prostate cancer. It is categorized according to the stage of the disease using the tumor node metastasis staging system 7th edition. The guidelines are presented with supporting evidence level, they are based on comprehensive literature review, several internationally recognized guidelines, and the collective expertise of the guidelines committee members (authors) who were selected by the Saudi oncology s...



Undiagnosed prostatic malignancy at the time of radical cystoprostatectomy after prior prostatic radiation therapy

Tue, 22 Mar 2016 23:00:00 +0100

Conclusions: Despite prior XRT for PCa, less than one-third of patients had no prostatic disease at the time of RC. Routine prostatic sampling should be considered in these patients especially if considering the orthotopic diversion. (Source: Urology Annals)



Malignancies in a renal transplant population: The St. Michael's Hospital experience

Tue, 22 Mar 2016 23:00:00 +0100

The objective of this study was to analyze the rate and types of malignancies occurring in the St. Michael's Hospital renal transplant population and to determine whether our results were comparable to those previously published. Methods: After approval by the hospital's research ethic board, review of the records and pathology of the 1584 patients in the renal transplant clinic database patients was performed. The reports dated back to the year 1970. Results: Amongst the 1584 renal transplant patients, 106 patients with 132 dysplastic and malignant posttransplant lesions were identified. The highest incidence amid the malignancies was in nonmelanoma skin malignancies squamous cell carcinoma (SCC), basal cell carcinoma, and Kaposi sarcoma, with a total of 32 patient...

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Perivesical unicentric Castleman disease initially suspected to be metastatic prostate cancer

Tue, 22 Mar 2016 23:00:00 +0100

We report a case of a 64-year-old man with newly diagnosed low-volume, Gleason 3 + 3 = 6 prostate adenocarcinoma, who in considering active surveillance versus treatment was found to have a left perivesical and iliac chain lymphadenopathy concerning for potential metastatic involvement. He underwent magnetic resonance imaging with ferumoxytol to assist in the diagnostic evaluation to better characterize his lymphadenopathy. Subsequently, he underwent robotic-assisted laparoscopic bilateral pelvic lymph node dissection and resection of left perivesical mass exhibiting hyaline vascular variant of UCD. (Source: Urology Annals)



Germline SFTPA1 mutation in familial idiopathic interstitial pneumonia and lung cancer

Tue, 22 Mar 2016 23:00:00 +0100

This study investigates IIP pathophysiology in 12 families affected by IPF and lung cancer. We identified, in a multigenerational family, nine members carrying a heterozygous missense mutation with evidence of pathogenicity in SFTPA1 that encodes the surfactant protein (SP)-A1. The mutation (p.Trp211Arg), which segregates with a disease phenotype characterized by either isolated IIP/IPF, or IPF associated with lung adenocarcinoma, is located in the carbohydrate recognition domain (CRD) of SP-A1 and involves a residue invariant throughout evolution, not only in SP-A1, but also in its close paralog SP-A2 and other CRD-containing proteins. As shown through functional studies, the p.Trp211Arg mutation impairs SP-A1 secretion. Immunohistochemistry studies on patient alveolar epithelium showed a...



Preoperative Differential Diagnosis of Canine Adrenal Tumors Using Triple‐Phase Helical Computed Tomography

Tue, 22 Mar 2016 23:00:00 +0100

ConclusionThe differential diagnosis of canine adrenal tumors was feasible based on triple‐phase CT findings, including morphological features, CT values, and intratumoral contrast attenuation. Preoperative diagnosis using triple‐phase helical CT may be useful for surgical planning in dogs with adrenal tumors. (Source: Veterinary Surgery)



Mixed squamous cell and glandular papilloma of the lung resembling early adenocarcinoma: A case report

Tue, 22 Mar 2016 23:00:00 +0100

Conclusion Both pre- and intraoperative diagnoses may be difficult mainly because of the rareness of the disease. The diagnosis of mixed squamous cell and glandular papilloma should be considered in case the presence of adenocarcinoma is not totally ruled out. (Source: Annals of Medicine and Surgery)



FDG-PET Based Differential Uptake Volume Histograms: A Possible Approach Towards Definition of Biological Target Volumes.

Tue, 22 Mar 2016 23:00:00 +0100

CONCLUSION: FDG-based PET data potentially may be used to identify biological target volumes (BTV) within the tumour in NSCLC patients. Using the one-way ANOVA statistical tests we found a significant difference among all threshold levels amongst adenocarcinomas, large cell carcinoma, and squamous cell carcinomas. On the other hand, the observed significant variability in threshold values throughout the patient cohort (expressed as large standard deviations) can be explained as a consequence of differences in the physiological status of the tumour volume for each patient at the time of the PET/CT scan. This further suggests that patient-specific threshold values for definition of BTVs could be determined by creation and curve fitting of dUVHs on a patient-by-patient basis. Advances in know...

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The Value of miR-299-5p in Diagnosis and Prognosis of Intestinal-Type Gastric Adenocarcinoma.

Tue, 22 Mar 2016 23:00:00 +0100

Authors: Azarbarzin S, Hosseinpour Feizi MA, Safaralizadeh R, Ravanbakhsh R, Kazemzadeh M, Fateh A, Karimi N, Moaddab Y Abstract MicroRNAs (miRNAs) are a class of non-coding RNAs, containing about 22 nucleotides and having a pivotal function in various cellular processes. The oncogenic and tumor suppressor roles of miRNAs have been identified in cancers especially in gastric cancer, which is one of the most prevalent cancers. MiR-299-5p is located in the imprinted Dlk1-Dio3 region in chromosome 14q32. Aberrant expression of miR-299-5p was determined in solid and blood cancers. The current study was performed to assess the expression pattern of miR-299-5p in intestinal-type gastric adenocarcinoma and compare it with the normal adjacent counterparts. The expression level of miR-299-5...



Molecular and Genetic Basis of Pancreatic Carcinogenesis

Tue, 22 Mar 2016 11:43:23 +0100

Carcinogenic progression in the pancreas arises through a well-established stepwise accumulation of molecular aberrations from a normal cell to an invasive adenocarcinoma. Recent large-scale sequencing efforts have provided insight into novel driver genes as well as enriched core signaling pathways that underlie the inherent heterogeneity found in pancreatic cancer. By exploiting these genomic profiles, we may begin to provide new insights into patient stratification and therapeutic guidance. This review discusses the molecular landscape of pancreatic cancer and its role in tumor progression, clinical prognostication, and the development of novel therapeutic strategies. (Source: Surgical Oncology Clinics of North America)



Q787Q EGFR Polymorphism as a Prognostic Factor for Lung Squamous Cell Carcinoma

Tue, 22 Mar 2016 05:38:10 +0100

Conclusions: The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II.Oncology (Source: Oncology)



Predictive imaging of chemotherapeutic response in a transgenic mouse model of pancreatic cancer

Tue, 22 Mar 2016 05:34:49 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)



Survival with nonmelanoma skin cancer in Germany

Tue, 22 Mar 2016 00:00:00 +0100

ConclusionsA comprehensive overview of NMSC survival in Germany is provided. The differences between the NMSC subtypes require a more differentiated consideration of patient survival. The survival advantage of patients with BCC may be related to health‐promoting factors related to the BCC diagnosis, such as changes to a healthier lifestyle. (Source: British Journal of Dermatology)

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Magnetic solid lipid nanoparticles in hyperthermia against colon cancer

Tue, 22 Mar 2016 00:00:00 +0100

Publication date: 17 May 2016 Source:International Journal of Pharmaceutics, Volume 504, Issues 1–2 Author(s): María Muñoz de Escalona, Eva Sáez-Fernández, José C. Prados, Consolación Melguizo, José L. Arias A reproducible double emulsion/solvent evaporation procedure is developed to formulate magnetic solid lipid nanoparticles (average size≈180nm) made of iron oxide cores embedded within a glyceryl trimyristate solid matrix. The physicochemical characterization of the nanocomposites ascertained the efficacy of the preparation conditions in their production, i.e. surface properties (electrokinetic and thermodynamic data) were almost indistinguishable from those of the solid lipid nanomatrix, while electron microscopy characterizations and X-ray diffraction patterns confir...



Severe myositis of the hip flexors after pre-operative chemoradiation therapy for locally advanced rectal cancer: case report

Tue, 22 Mar 2016 00:00:00 +0100

The use of neoadjuvant radiation therapy and chemotherapy in the treatment of locally advanced rectal adenocarcinoma has been shown to reduce disease recurrence when combined with surgery and adjuvant chemothe... (Source: BMC Cancer)



ERBB2 (HER2) Testing in Breast Cancer

Tue, 22 Mar 2016 00:00:00 +0100

Diagnostic mammography revealed 2 masses in the left breast of a 35-year-old woman. Image-guided core biopsies revealed a poorly differentiated invasive ductal adenocarcinoma. Estrogen receptor was strongly positive in 95% of tumor cells, progesterone receptor was positive in less than 5% of tumor cells, and ERBB2 (HER2) by immunohistochemistry was scored at 1+. How do you interpret the test results? (Source: JAMA)



MabVax begins Phase I trial of fully human antibody HuMab-5B1 to treat pancreatic cancer

Tue, 22 Mar 2016 00:00:00 +0100

US-based MabVax Therapeutics has started a Phase I clinical trial of HuMab-5B1, a fully human antibody, to treat patients with locally advanced or metastatic adenocarcinoma of the pancreas (PDAC) or other CA19-9 positive malignancies. (Source: Drug Development Technology)



Q787Q EGFR Polymorphism as a Prognostic Factor for Lung Squamous Cell Carcinoma.

Mon, 21 Mar 2016 23:00:00 +0100

CONCLUSIONS: The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II. PMID: 26999786 [PubMed - as supplied by publisher] (Source: Oncology)

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A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species

Mon, 21 Mar 2016 23:00:00 +0100

This study examines the effects of the DNA methyltransferase (DNMT) inhibitor 5-Azacytidine (5-AzaC) on normal and tumoral mammary cell lines derived from dogs, cats and humans, as proof of concept that small companion animals are useful models of human breast cancer. Our findings show that treatment with 5-AzaC reduces in vitro tumorigenicity in all three species based on growth and invasion assays, mitochondrial activity and susceptibility to apoptosis. Interestingly, we found that the effects of 5-AzaC on gene expression varied not only between the different species but also between different tumoral cell lines within the same species, and confirmed the correlation between loss of methylation in a specific gene promotor region and increased expression of the associated gene using bisulf...



Id: 34: association between vitamin d and gastric cancer

Mon, 21 Mar 2016 23:00:00 +0100

Conclusion The results of our study suggest that there is a positive correlation between vitamin D deficiency and gastric adenocarcinoma. More specifically patients with vitamin D deficiency have an increased association with GA. Additional multicenter randomized double blind clinical trials are required to further assess this association and the potential benefit of vitamin D supplementation in preventing gastric adenocarcinoma. Abstract ID: 34 Figure 1 (Source: Journal of Investigative Medicine)



Id: 38: primary squamos cell carcinoma of the rectum

Mon, 21 Mar 2016 23:00:00 +0100

In conclusion, SCC of rectum is a distinct entity and it is important to shed some light on this rare condition because it has different epidemiology, etiology, pathogenies and requires a different treatment approach than other colorectal carcinomas. Surgery is the primary treatment which consists of local excision versus radical resection and the need for adjuvant therapy. Abstract ID: 38 Figure 1 (Source: Journal of Investigative Medicine)



Unusual Uptake of Prostate Specific Tracer 68 Ga-PSMA–HBED-CC in a Benign Thyroid Nodule

Mon, 21 Mar 2016 23:00:00 +0100

We present here the case of a 62-year-old male patient who underwent prostatectomy for adenocarcinoma prostate. He also had a long-standing left solitary thyroid nodule (STN). Four months after surgery, he had a rising trend in serum PSA levels on three occasions, but the absolute value was less than 4 at all times. He underwent a 68Ga-PSMA-HBED-CC PET/CT, but it did not reveal any recurrent/metastatic site of disease. However, there was increased tracer uptake in the left STN. Fine needle aspiration cytology revealed features of atypia of undetermined significance, Bethesda category III. The patient underwent a left hemithyroidectomy and the histopathology showed features of a follicular adenoma. (Source: Nuclear Medicine and Molecular Imaging)



Mucins MUC16 and MUC1 are major carriers of SLe a and SLe x in borderline and malignant serous ovarian tumors

Mon, 21 Mar 2016 23:00:00 +0100

Abstract Mucins are heavily glycosylated proteins overexpressed and associated with truncated or sialylated glycans upon malignant transformation. We previously identified a panel of four glyco-mucin profiles (MUC16/Tn, MUC16/STn, MUC1/Tn, and MUC1/STn) with 100 % specificity and 100 % positive predictive value for detection of borderline/malignant serous tumors of the ovary, using proximity ligation assay (PLA). In the present work, using the same method, we studied other mucin glycosylation profiles that might add relevant information for diagnostic purposes. We used PLA probes to MUC16, MUC1, sialyl Lewisa (SLea), and sialyl Lewisx (SLex) to study a series of 39 ovarian serous tumors (14 adenocarcinomas, 10 borderline ovarian tumors (BOTs), and 15 cystadenomas). Our results d...

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Percutaneous transthoracic localization of pulmonary nodules under C-arm cone-beam CT virtual navigation guidance.

Mon, 21 Mar 2016 23:00:00 +0100

CONCLUSION: PTL procedures can be performed safely and accurately under the guidance of a CBCT virtual navigation system. PMID: 27015318 [PubMed - as supplied by publisher] (Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology)



Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier.

Mon, 21 Mar 2016 05:47:03 +0100

CONCLUSIONS: This study identified and validated a highly accurate 5-gene PDAC classifier for discriminating PDAC and early precursor lesions from non-malignant tissue that may facilitate early diagnosis and risk stratification upon validation in prospective clinical trials. Cell-based experiments of two overexpressed proteins encoded by the panel, TMPRSS4 and ECT2, suggest a causal link to PDAC development and progression, confirming them as potential therapeutic targets. PMID: 26993610 [PubMed - as supplied by publisher] (Source: Oncotarget)



Urachal Adenocarcinoma in a Dog

Mon, 21 Mar 2016 00:00:00 +0100

Publication date: Available online 20 March 2016 Source:Journal of Comparative Pathology Author(s): S. Shrader, J. Lauridson, Z. King, J. Loch An 8-year-old neutered female Labrador retriever was presented with a 3-year history of intermittent haematuria. Ultrasonographic evaluation of the urinary bladder revealed a 2 × 3 × 0.5 cm intraluminal mass arising at the dome. The mass was excised via partial cystectomy. Histopathological examination revealed neoplastic epithelial cells arranged in sheets, irregularly-branching tubules and acini within a fibrovascular stroma. Neoplastic cells were cuboidal to polygonal with abundant foamy amphophilic cytoplasm, typically with a single, large, clear intracytoplasmic vacuole and eccentric nucleus (‘signet ring’ cells). Neoplastic tu...



Genomic analysis of HPV-positive versus HPV-negative oesophageal adenocarcinoma identifies a differential mutational landscape

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions These findings demonstrate distinct genomic differences between HPV-positive and HPV-negative OACs indicating different biological mechanisms of tumour formation. (Source: Journal of Medical Genetics)



Exploiting the biological roles of the trypsin inhibitor from Inga vera seeds: a multifunctional Kunitz inhibitor

Mon, 21 Mar 2016 00:00:00 +0100

Publication date: Available online 19 March 2016 Source:Process Biochemistry Author(s): Cézar da Silva Bezerra, Caio Fernando Ramalho de Oliveira, Olga Lima Tavares Machado, Gabriela Souto Vieira de Mello, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva, Suzanna de Fátima Ferreira Ribeiro, Valdirene Moreira Gomes, Osmar Nascimento Silva, Simone Maria-Neto, Octávio Luiz Franco, Maria Lígia Rodrigues Macedo Here, the purification, biochemical and biological properties of a trypsin inhibitor from Inga vera seeds (IVTI) are described. Partial amino acid sequence of IVTI showed that it belongs to the MEROPS I03 Kunitz inhibitor family. Moreover, it is composed of a single 20kDa polypeptide chain with o...

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Whole‐exome sequencing of duodenal adenocarcinoma identifies recurrent Wnt/β‐catenin signaling pathway mutations

Mon, 21 Mar 2016 00:00:00 +0100

CONCLUSIONSThis genomic characterization of duodenal adenocarcinoma provides researchers with insight into its somatic landscape and highlights the vital role of the Wnt/β‐catenin signaling pathway. The study data also indicate that duodenal adenocarcinomas have a genetic resemblance to gastric and colorectal cancers. These discoveries may benefit the future development of molecular diagnosis and personalized therapies. Cancer 2016. © 2016 American Cancer Society. (Source: Cancer)



Enteroscopy and radiology for the management of celiac disease complications: Time for a pragmatic roadmap

Mon, 21 Mar 2016 00:00:00 +0100

Celiac disease is the most common autoimmune enteropathy in Western countries, and is usually associated with a good response to the gluten free diet and an excellent prognosis. However, a minority of patients develop complications of the disease, such as refractory celiac disease, ulcerative jejunoileitis and neoplastic complications such as adenocarcinoma of the small bowel and enteropathy associated T cell lymphoma. Neoplastic complications described in association with celiac disease have a high mortality rate, due to their aggressive behavior and to the usual advanced stage at the time of diagnosis. (Source: Digestive and Liver Disease)



Clinical Reasoning: Stepwise paralysis in a patient with adenocarcinoma of lung

Mon, 21 Mar 2016 00:00:00 +0100

A 54-year-old man presented with pain in the left chest for 3 days. His medical history was remarkable for hyperlipidemia managed with diet and statin. He denied tobacco smoking and consumption of alcohol. Physical examination was unrevealing. The patient was diagnosed with an adenocarcinoma of the lung harboring an epidermal growth factor receptor (EGFR) mutation that metastasized to T2-T4 levels. He was treated with radiotherapy and dexamethasone followed by Gefitinib. (Source: Neurology)



Carbocisteine attenuates TNF-α-induced inflammation in human alveolar epithelial cells in vitro through suppressing NF-κB and ERK1/2 MAPK signaling pathways.

Sun, 20 Mar 2016 23:00:00 +0100

CONCLUSION: Carbocisteine effectively suppresses TNF-α-induced inflammation in A549 cells via suppressing NF-κB and ERK1/2 MAPK signaling pathways. PMID: 26997568 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)