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Preview: MedWorm: Colorectal Cancer

MedWorm: Colorectal Cancer provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Colorectal Cancer category.

Last Build Date: Tue, 29 Mar 2016 16:48:46 +0100


Faith and family helped this young cancer survivor

Tue, 29 Mar 2016 10:23:47 +0100

The same week she was set to graduate from college, Adalis Martinez found out she had colon cancer (Source: Health News:

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Common variables in European pancreatic cancer registries: the introduction of the EURECCA pancreatic cancer project

Mon, 28 Mar 2016 22:00:00 +0100

Conclusions A list of 25 shared items on pancreatic cancer coming from eleven participating registries was created, providing a basis for future prospective data collection in pancreatic cancer treatment internationally. (Source: European Journal of Surgical Oncology (EJSO))

Histological Subtype and Systemic Metastases Strongly Influence Treatment and Survival in Patients with Synchronous Colorectal Peritoneal Metastases

Mon, 28 Mar 2016 22:00:00 +0100

Conclusions Histological subtype and the presence of systemic metastases strongly influenced treatment choice and survival in patients with synchronous colorectal PM. These results can be used to optimize treatment strategy for patients with synchronous colorectal PM. (Source: European Journal of Surgical Oncology (EJSO))

Young colon cancer survivor inspired by faith, family

Mon, 28 Mar 2016 21:22:13 +0100

Adalis Martinez was diagnosed with colon cancer the week of her college graduation; faith and her loved ones helped her get through it (Source: Health News:

Germline mutations of the DNA repair pathways in uterine serous carcinoma.

Mon, 28 Mar 2016 20:57:02 +0100

CONCLUSIONS: A significant proportion of our cohort harbor germline mutations in DNA repair genes. This may be associated with the high rate of breast cancer in our patients and their family, and suggests a targeted cohort for genetic counseling. If validated in a larger cohort, our findings may allow clinicians to expand therapeutic options to include targeted therapies and inclusion of USC patient in preventative and genetic counseling. PMID: 27016235 [PubMed - in process] (Source: Gynecologic Oncology)

Mp39-19 prostate cancer detection with digital rectal exam in the prostate lung colorectal and ovarian (plco) cancer screening trial

Mon, 28 Mar 2016 19:24:11 +0100

There has been great controversy regarding prostate cancer screening with prostate specific antigen (PSA) due to conflicting results from two large randomized trials. However, the contemporary role of digital rectal exam (DRE) for screening has been largely overlooked. This is particularly salient given the recent decline in PSA and possibly overall prostate cancer screening. We sought to evaluate the prognostic significance of suspicious DRE in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Trial in which men were randomized to annual screening with PSA and DRE or usual care. (Source: The Journal of Urology)

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Mp39-11 baseline psa before age 60 as a predictor of important prostate cancer diagnosis and prostate cancer-specific mortality in the intervention arm of the prostate, lung, colorectal and ovarian trial

Mon, 28 Mar 2016 19:24:11 +0100

The Prostate, Lung, Colorectal and Ovarian (PLCO) study evaluated the impact of organized annual PSA screening on prostate cancer (PCa) incidence and PCa-specific mortality. We sought to determine the future risk of clinically significant PCa diagnosis based on a baseline PSA (bPSA) measurement in younger men at study entry. (Source: The Journal of Urology)

Pd15-05 lethal prostate cancer in the plco cancer screening trial

Mon, 28 Mar 2016 19:24:07 +0100

In this study, our aim is to describe the clinical course of men who ultimately died of prostate cancer in the screening arm of PLCO. (Source: The Journal of Urology)

Mp63-07 the association between preoperative leukocytosis and postoperative outcomes following cystectomy for bladder cancer

Mon, 28 Mar 2016 19:24:07 +0100

The objective of this study is to evaluate whether leukocytosis is associated with postoperative complications and mortality following radical cystectomy for bladder cancer. (Source: The Journal of Urology)

Mp73-20 analgesic use and risk of renal cell cancer: results from two prospective cohort studies

Mon, 28 Mar 2016 19:24:05 +0100

Analgesics are the most common over-the-counter drugs worldwide and considerable evidence suggests a beneficial effect of analgesics, especially aspirin, on cardiovascular diseases and colorectal cancer. However, the relationship between the widely used analgesics (i.e., aspirin, other nonsteroidal anti-inflammatory drugs (NSAID), and acetaminophen) and risk of total and lethal renal cell cancer remains unclear. (Source: The Journal of Urology)

Mp35-05 digital rectal exam and prostate size for the evaluation of benign prostate pathology: an analysis of 30,500 men presenting for screening exams in the plco cancer screening trial

Mon, 28 Mar 2016 19:24:05 +0100

Though the digital rectal exam (DRE) is a key component of prostate cancer screening, its utility in the workup of lower urinary tract symptoms is poorly understood. Nocturia is among the most bothersome lower urinary tract symptoms, and its multifactorial etiology requires broad clinical evaluation. Using data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, this study aims to assess the accuracy and reliability of DRE in estimating prostate size, and to correlate these findings with the presence of nocturia (Source: The Journal of Urology)

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Pd39-01 prophylactic use of an intraperitoneal onlay mesh during ileal conduit urinary diversion for the prevention of parastomal hernias. initial experience

Mon, 28 Mar 2016 19:24:05 +0100

Parastomal hernias develop in a quarter of patients within one year after cystectomy and ileal conduit urinary diversion (RC/IC) and half of patients within 2 years. Prophylactic placement of mesh during surgery has been described in colorectal surgery to be safe and effective. (Source: The Journal of Urology)

Mp08-01 perioperative blood transfusion and radical prostatectomy: analysis of the national surgical quality improvement program database

Mon, 28 Mar 2016 19:24:03 +0100

Radical prostatectomy remains a mainstay in the treatment of clinically significant localized prostate cancer. The literature suggest that perioperative blood transfusion (PBT) in oncologic surgeries may lead to poorer long-term outcomes of recurrence, progression, and survival, for colon, pancreatic, esophageal and gynecologic malignancies. Previous studies have not shown this to be true for prostatectomy but there has yet to be a study examing the impact of PBT on 30-day post-operative outcomes. (Source: The Journal of Urology)

Mp06-06 prospective preoperative evaluation of patients undergoing radical cystectomy: the schonberg mortality index outperforms other frailty and malnutrition assessments for the prediction of 30-day readmission and complications

Mon, 28 Mar 2016 19:24:03 +0100

We present interim analysis of a prospective pilot evaluating pre-operative frailty indices (FI). (Source: The Journal of Urology)

Mp18-15 efficacy of high intensity focused ultrasound (hifu) as a primary monotherapy for low risk localized prostate cancer: outcomes from the enlight trial

Mon, 28 Mar 2016 19:24:01 +0100

Introduction and Objective: Between 2007 and 2010 transrectal ultrasound guided high intensity focused ultrasound (HIFU) was employed in a FDA approved IDE registration clinical trial (ENLIGHT Trial) in men with low grade, low risk prostate cancer. Efficacy outcomes are reported. (Source: The Journal of Urology)

Mp91-12 vasectomy and risk of prostate cancer in a screening trial

Mon, 28 Mar 2016 19:24:01 +0100

Vasectomy has been implicated as a risk factor for prostate cancer in multiple epidemiologic studies over the past 25 years. Whether this relationship is causal or due to unaccounted for bias remains unclear. The Prostate, Lung, Colorectal, Ovarian (PLCO) Cancer Screening Trial provided a unique opportunity to assess the relationship between vasectomy and prostate cancer in a modern cohort of men who were uniformly screened for prostate cancer. (Source: The Journal of Urology)

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S&t-50 does transperineal prostate biopsy reduce complications compared with transrectal biopsy? a systematic review and meta-analysis of randomised controlled trials

Mon, 28 Mar 2016 19:24:00 +0100

The detection of prostate cancer relies in part upon the two established techniques of transperineal (TP) and transrectal (TR) prostate biopsy. The more commonly used TR biopsy is associated with higher rates of infective complications, as it traverses the rectum. This systematic review and meta-analysis aims to determine if any difference in complication rate exists between TR and TP prostate biopsy. (Source: The Journal of Urology)

Pi-lba02 reevaluating psa testing rates in the plco trial

Mon, 28 Mar 2016 19:23:59 +0100

Much of the controversy surrounding prostate specific antigen (PSA) screening revolves around the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. The PLCO trial randomized men to annual prostate cancer screening or usual care and found equivalency in the primary outcome of prostate cancer specific mortality. The major criticism of this trial relates to the degree of PSA testing in the control arm of the study, which has been interpreted by many, including by the United States Preventative Services Task Force, as ″approximately 50% of men in the control group received at least 1 PSA test during the study.″ (Source: The Journal of Urology)

Erratum: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.

Mon, 28 Mar 2016 17:23:02 +0100

Authors: Nam SH, Kim D, Lee MS, Lee D, Kwak TK, Kang M, Ryu J, Kim HJ, Song HE, Choi J, Lee GH, Kim SY, Park SH, Kim DG, Kwon NH, Kim TY, Thiery JP, Kim S, Lee JW Abstract See original article: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels. PMID: 27016622 [PubMed - as supplied by publisher] (Source: Oncotarget)

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon.

Mon, 28 Mar 2016 17:23:02 +0100

Authors: Xiao J, Duan Q, Wang Z, Yan W, Sun H, Xue P, Fan X, Zeng X, Chen J, Shao C, Zhu F Abstract T-LAK cell-originated protein kinase (TOPK), a serine/threonine protein kinase, is highly expressed in a variety of tumors and associated with a poor prognosis of human malignancies. However, the activation mechanism of TOPK is still unrevealed. Herein, first we found that Src directly bound with and phosphorylated TOPK at Y74 and Y272 in vitro. Anti-phospho-TOPK at Y74 was prepared, the endogenous phosphorylation of TOPK at Y74 was detected in colon cancer cells, and the phosphorylation was inhibited in cells expressing low levels of Src. Subsequently, we stably transfected Y74 and Y272 double mutated TOPK (TOPK-FF) into JB6 or SW480 cells, and observed that both the anchorage-indep...

Genetic Test May Identify CRC Risk in 'Normals'Genetic Test May Identify CRC Risk in 'Normals'

Mon, 28 Mar 2016 16:30:13 +0100

A study describes a genetic 'signature' able to identify normal individuals at higher and lower risk of developing colorectal cancer--which has strong implications for screening, says Dr David Kerr. Medscape Oncology (Source: Medscape Pathology Headlines)

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The U.S. Throws Out $3 Billion In Cancer Drugs Every Year

Mon, 28 Mar 2016 15:39:32 +0100

(Reuters Health) - U.S. doctors and hospitals throw out almost $3 billion (roughly 2.7 billion euros) in unused cancer drugs each year because the medicines come in supersized single-use packages and excess medicine must be discarded for safety reasons, a recent paper suggests. Researchers focused on 20 expensive medicines that are given by injection or intravenous drip and require doses adjusted based on the patient’s body size. Often, the packages contain much more medicine than patients need, and the leftovers wind up in the trash. Even when much of the medicine goes in the garbage, patients pay for the whole vial, said lead author Dr. Peter Bach, director of the Center for Health Policy and Outcomes at Memorial Sloan Kettering Cancer Center in New York City. “...

Effect of food on the pharmacokinetics of TAS‐102 and its efficacy and safety in patients with advanced solid tumors

Sun, 27 Mar 2016 22:00:00 +0100

This study demonstrates that postprandial administration after morning and evening meals is considered to be an adequate regimen for TAS‐102. Furthermore, the results suggest that TAS‐102 would be an effective treatment for various carcinomas, especially small cell lung, thymic, and colorectal cancers. (Source: Cancer Science)

Preclinical and first‐in‐human phase I studies of KW‐2450, an oral tyrosine kinase inhibitor with insulin‐like growth factor receptor‐1/insulin receptor selectivity

Sun, 27 Mar 2016 22:00:00 +0100

Numerous solid tumors overexpress or have excessively activated insulin‐like growth factor receptor‐1 (IGF‐1R). We summarize preclinical studies and the first‐in‐human study of KW‐2450, an oral tyrosine kinase inhibitor with IGF‐1R and insulin receptor (IR) inhibitory activity. Preclinical activity of KW‐2450 was evaluated in various in vitro and in vivo models. It was then evaluated in a phase I clinical trial in 13 patients with advanced solid tumors (NCT00921336). In vitro, KW‐2450 inhibited human IGF‐1R and IR kinases (IC50 7.39 and 5.64 nmol/L, respectively) and the growth of various human malignant cell lines. KW‐2450 40 mg/kg showed modest growth inhibitory activity and inhibited IGF‐1‐induced signal transduction in the murine HT‐29/GFP colon carcinoma xe...

Colonoscopy Surveillance after Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer

Sun, 27 Mar 2016 22:00:00 +0100

Authors: Charles J Kahi, C Richard Boland, Jason A Dominitz, Francis M Giardiello, David A Johnson, Tonya Kaltenbach, David Lieberman, Theodore R Levin, Douglas J Robertson & Douglas K Rex (Source: The American Journal of Gastroenterology)

Colonoscopy Reduces Colorectal Cancer Incidence and Mortality in Patients With Non-Malignant Findings: A Meta-Analysis

Sun, 27 Mar 2016 22:00:00 +0100

Authors: Jun Pan, Lei Xin, Yi-Fei Ma, Liang-Hao Hu & Zhao-Shen Li (Source: The American Journal of Gastroenterology)

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TUSC3 promotes colorectal cancer progression and epithelial–mesenchymal transition (EMT) through WNT/β‐catenin and MAPK signalling

Sun, 27 Mar 2016 22:00:00 +0100

In conclusion, our study demonstrated the oncogenic role of TUSC3 in CRC and showed that TUSC3 may be responsible for alternations in the proliferation ability, aggressiveness, and invasive/metastatic potential of CRC through regulating the MAPK, PI3K/Akt, and Wnt/β‐catenin signalling pathways. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. (Source: The Journal of Pathology)

SERPINI1 regulates epithelial–mesenchymal transition in an orthotopic implantation model of colorectal cancer

Sun, 27 Mar 2016 22:00:00 +0100

An increasingly accepted concept is that the progression of colorectal cancer is accompanied by epithelial–mesenchymal transition (EMT). In our study, in order to characterize the properties of EMT in 16 colorectal cancer cell lines, the cells were first orthotopically implanted into nude mice, and the tumors in vivo, as well as cells cultured in vitro, were immunostained for EMT markers. The immunostaining revealed that seven of the cells had an epithelial phenotype with a high expression of E‐cadherin, whereas other cells showed opposite patterns, such as a high expression of vimentin (CX‐1, COLO205, CloneA, HCT116, and SW48). Among the cells expressing vimentin, some expressed vimentin in the orthotopic tumors but not in the cultured cells (SW480, SW620, and COLO320). We evaluated...

Autophagy inhibition sensitizes WYE-354-induced anti-colon cancer activity in vitro and in vivo

Sun, 27 Mar 2016 22:00:00 +0100

Abstract Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) and mTORC2 are frequently dysregulated in human colon cancers. In the present study, we evaluated the potential anti-colon cancer cell activity by a novel mTORC1/2 dual inhibitor WYE-354. We showed that WYE-354 was anti-survival and anti-proliferative when adding to primary (patient-derived) and established (HCT-116, HT-29, Caco-2, LoVo, and DLD-1 lines) colon cancer cells. In addition, WYE-354 treatment activated caspase-dependent apoptosis in the colon cancer cells. Mechanistically, WYE-354 blocked mTORC1 and mTORC2 activation. Meanwhile, it also induced autophagy activation in the colon cancer cells. Autophagy inhibitors (bafilomycin A1 and 3-methyladenine), or shRNA-mediated knockdown of autophagy elements (Becli...

Rectal and bladder dose reduction with the addition of intravaginal balloons to vaginal packing in intracavitary brachytherapy for cervical cancer

Sun, 27 Mar 2016 22:00:00 +0100

The use of intravaginal Foley balloons in addition to conventional packing during high-dose–rate (HDR) tandem and ovoids intracavitary brachytherapy (ICBT) is a means to improve displacement of organs at risk, thus reducing dose-dependent complications. The goal of this project was to determine the reduction in dose achieved to the bladder and rectum with intravaginal Foley balloons with CT-based planning and to share our packing technique. (Source: Brachytherapy)

Sensitivity of 2-[ 18 F]fluoro-2-deoxyglucose positron emission tomography for advanced colorectal neoplasms: a large-scale analysis of 7505 asymptomatic screening individuals

Sun, 27 Mar 2016 22:00:00 +0100

Conclusions FDG-PET is believed to be difficult to use as a primary screening tool in population-based colorectal cancer screening because of its low sensitivity for advanced neoplasms. Even when it is used in opportunistic cancer screening, the limit of its sensitivity should be considered. (Source: Journal of Gastroenterology)

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Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

Sun, 27 Mar 2016 22:00:00 +0100

Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide with an increased prevalence of metabolic, macro-, and microvascular complications. The primary causes of mortality in NAFLD are cardiovascular disease (CVD), malignancy, and liver disease. NAFLD is a multisystem disease that affects a variety of extrahepatic organ systems. The main focus of this review is to summarize the reported extrahepatic associations, which include CVD, chronic kidney disease, obstructive sleep apnea, osteoporosis, psoriasis, colorectal cancer, iron overload, and various endocrinopathies (e.g., type 2 diabetes mellitus, thyroid dysfunction, and polycystic ovarian syndrome). Due to the systemic manifestations of NAFLD, patients require a multidiscipl...

Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis.

Sun, 27 Mar 2016 05:28:02 +0100

Authors: Chou CK, Fan CC, Lin PS, Liao PY, Tung JC, Hsieh CH, Hung MC, Chen CH, Chang WC Abstract Hepatic metastasis is the major cause of mortality in colorectal cancer (CRC) patients. Using proteomic analysis, we found sciellin (SCEL) to be specifically expressed in hepatic metastatic CRC cell lines. SCEL knockdown increased CRC cell migration and invasion, while overexpression had the opposite effect. SCEL knockdown also caused cancer cells to form more invasive structures within 3D cultures, increased the mesenchymal marker vimentin, and attenuated the epithelial marker E-cadherin. SCEL increased WNT signaling by activating β-catenin and its downstream target c-myc, and activated mesenchymal-to-epithelial transition (MET) through a SCEL-β-catenin-E-cadherin axis. SCEL showed ...

Choosing How to Treat Your Cancer

Sat, 26 Mar 2016 23:00:00 +0100

Choosing the right treatment option for colon cancer is an extremely personal choice. Your doctor can provide recommendations, but he or she cannot force you to make any decision. (Source: Colon Cancer)

Losing Unwanted Weight During Chemotherapy

Sat, 26 Mar 2016 23:00:00 +0100

Even if you're looking to lose a few pounds, you don't want to begin while on chemotherapy. Your body needs the nutrients to heal and repair damaged tissues. (Source: Colon Cancer)

How to Tell Whether Bowel Movement Changes Are...

Sat, 26 Mar 2016 23:00:00 +0100

Lasting changes in bowel movement frequency, color or consistency can signal a serious problem such as colon cancer. (Source: Colon Cancer)

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Ramucirumab: Boon or bane

Sat, 26 Mar 2016 23:00:00 +0100

Publication date: Available online 26 March 2016 Source:Journal of the Egyptian National Cancer Institute Author(s): Priya Tiwari Ramucirumab is the recent addition to the list of monoclonal antibodies being tried in various malignancies. It has been approved in non-small cell lung cancer, gastric cancer and colorectal cancer after progression of one or more lines of therapies in the advanced setting. Though randomized trials have shown benefit, cost effectiveness is questionable. Moreover, the benefits shown are marginal, putting a question mark over its clinical usage. This review summarizes the latest evidence on ramucirumab. (Source: Journal of the Egyptian National Cancer Institute)

Incarcerated inguinoscrotal hernia containing sigmoid colon cancer

Sat, 26 Mar 2016 23:00:00 +0100

(Source: ANZ Journal of Surgery)

Update on optimal treatment for metastatic colorectal cancer from the ACTG/AGITG expert meeting: ECCO 2015.

Sat, 26 Mar 2016 19:40:02 +0100

Authors: Price TJ, Thavaneswaran S, Burge M, Segelov E, Haller DG, Punt CJ, Arnold D, Karapetis CS, Tebbutt NC, Pavlakis N, Gibbs P, Shapiro JD Abstract The treatment of metastatic CRC (mCRC) has evolved over the last 20 years, from fluoropyrimidines alone to combination chemotherapy and new biologic agents. Median overall survival is now over 24 months for RAS mutated (MT) patients and over 30 months for RAS wild-type (WT) patients. However, there are subgroups of patients with BRAF V600E MT CRC who have a significantly poorer outlook. Newer treatment options are also being explored in select subgroups of patients (anti-HER 2 in HER2 positive mCRC and immunotherapy in patients with defective mismatch repair (dMMR)). The best use of these systemic treatment options, as well as surg...

Open surgery versus laparoscopic surgery after stent insertion for obstructive colorectal cancer

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion The patients who underwent laparoscopic resection had less blood loss, although no significant difference was found in postoperative morbidity or mortality. Thus, laparoscopic resection after stent insertion is a feasible and safe option for patients with obstructive colorectal cancer. (Source: Surgery Today)

Epidemiological characterization of ostomized patients attended in referral centers from the city of Maceió, Alagoas, Brazil

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion The study provides relevant data that can be used as input for prevention and strategies to improve the health of the ostomized population. (Source: Journal of Coloproctology)

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Immunohistochemical Expression of Proinflammatory Enzyme COX-2 and P53 in Ulcerative Colitis and its Associated Dysplasia and Colorectal Carcinoma

Fri, 25 Mar 2016 23:00:00 +0100

Conclusion Adding immunohistochemical analysis of cox-2 enzyme and p53 gene to routine histological assessment may improve the accuracy of early detection of dysplasia and colorectal cancer. COX-2 and p53 can be promising chemotherapeutic/chemopreventive targets in UC patients. (Source: Journal of Microscopy and Ultrastructure)

Loss of TINCR expression promotes proliferation, metastasis through activating EpCAM cleavage in colorectal cancer.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Zhang ZY, Lu YX, Zhang ZY, Chang YY, Zheng L, Yuan L, Zhang F, Hu YH, Zhang WJ, Li XN Abstract Long non-coding RNAs (lncRNAs) are involved in kinds of human diseases, including colorectal cancer (CRC). TINCR, a 3.7 kb long non coding RNA, was associated with cell differentiation in keratinocyte and gastric cancer cells. However, little is known about the role of TINCR in regulation CRC progression. Here, we showed that lncRNA TINCR was associated with CRC proliferation and metastasis. TINCR was statistically downregulated in CRC tissues and metastatic CRC cell lines compared with their counterparts. TINCR was reversely correlated with CRC progression and promoted tumor cells growth, metastasis in vivo and in vitro. While overexpression of TINCR had opposite effect. In addi...

Decreased level of RASSF6 in sporadic colorectal cancer and its anti-tumor effects both in vitro and in vivo.

Fri, 25 Mar 2016 17:33:04 +0100

In this study, we demonstrate that RASSF6 acts as a tumor suppressor in colon cancer cells. Decreased level of RASSF6 was observed in adenocarcinoma compared to normal tissues, especially in advanced tumor cases. Further experiments showed exogenous introduction of RASSF6 into LoVo cells suppressed cell proliferation, migration, invasion, and induced apoptosis in vitro as well as tumor growth in vivo. In contrast, knockdown of RASSF6 in HT-29 cells showed the opposite effects. Taken together, our results suggest, in addition to epigenetics changes, functional somatic mutations may also contribute to the downregulation of RASSF6 and further participate in the pathogenesis of sCRC. RASSF6 may serve as a novel candidate against tumor growth for sCRC. PMID: 27009808 [PubMed - as supplied b...

A scoring system based on artificial neural network for predicting 10-year survival in stage II A colon cancer patients after radical surgery.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Peng JH, Fang YJ, Li CX, Ou QJ, Jiang W, Lu SX, Lu ZH, Li PX, Yun JP, Zhang RX, Pan ZZ, Wan DS Abstract Nearly 20% patients with stage II A colon cancer will develop recurrent disease post-operatively. The present study aims to develop a scoring system based on Artificial Neural Network (ANN) model for predicting 10-year survival outcome. The clinical and molecular data of 117 stage II A colon cancer patients from Sun Yat-sen University Cancer Center were used for training set and test set; poor pathological grading (score 49), reduced expression of TGFBR2 (score 33), over-expression of TGF-β (score 45), MAPK (score 32), pin1 (score 100), β-catenin in tumor tissue (score 50) and reduced expression of TGF-β in normal mucosa (score 22) were selected as the prognostic risk...

DDX3 enhances oncogenic KRAS‑induced tumor invasion in colorectal cancer via the β‑catenin/ZEB1 axis.

Fri, 25 Mar 2016 17:33:04 +0100

In conclusion, DDX3 may play an oncogenic role to promote tumor growth and invasion in colon cancer cells via the β-catenin/ZEB1 axis due to increasing KRAS transcription. We therefore suggest that AKT or β-catenin may potentially act as a therapeutic target to improve tumor regression and outcomes in colorectal cancer patients who harbored high-DDX3 tumors. PMID: 27007150 [PubMed - as supplied by publisher] (Source: Oncotarget)

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Integrated analysis of long non-coding RNAs in human colorectal cancer.

Fri, 25 Mar 2016 17:33:04 +0100

Authors: Chen X, Liu B, Yang R, Guo Y, Li F, Wang L, Hu H Abstract Accumulating evidence highlights the role of long non-coding RNAs (lncRNAs) in tumors. However, the genome-wide expression and roles of lncRNAs in colorectal cancer (CRC) remain unknown. Here, we systematically examined the global gene expressions in primary and synchronous liver metastases CRC tissue, in which thousands of aberrantly expressed lncRNAs were characterized. Co-expression analysis revealed that some lncRNAs correlated to their neighboring mRNAs in expression levels, whereas others formed networks with protein-coding genes in trans. We observed H3K4me3 was enriched at expressed lncRNA transcription start sites (TSSs) and correlated to dysregulated lncRNAs. Furthermore, we identified primary and metastas...

Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents.

Fri, 25 Mar 2016 16:53:02 +0100

Authors: Harris RA, Shah R, Hollister EB, Tronstad RR, Hovdenak N, Szigeti R, Versalovic J, Kellermayer R Abstract Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC...

Distance Matters for Quality Rectal Cancer Care

Fri, 25 Mar 2016 16:00:00 +0100

The farther a patient has to travel for radiation therapy, the less likely it will happen, study finds Source: HealthDay Related MedlinePlus Pages: Colorectal Cancer, Radiation Therapy (Source: MedlinePlus Health News)

Elevated serum levels of MMP-11 correlate with poor prognosis in colon cancer patients.

Fri, 25 Mar 2016 15:40:03 +0100

CONCLUSION: Our study established that high serum levels of MMP-11 are associated with poor clinical outcome and may serve as a prognostic biomarker in colon cancer patients. PMID: 27002762 [PubMed - as supplied by publisher] (Source: Cancer Biomarkers)

Hepatic Tumor Ablation

Fri, 25 Mar 2016 15:35:28 +0100

Tumor ablation is a safe and effective treatment available in the multidisciplinary care of the surgical oncology patient. The role of ablation is well established in the treatment of hepatocellular carcinoma and is becoming more accepted in the treatment of various malignancies metastatic to the liver, in particular colorectal cancer. Understanding the underlying technology, achieving appropriate applicator placement, using maximum energy delivery to create margins, and performing necessary adjunctive maneuvers are all required for successful tumor ablation. (Source: Surgical Clinics of North America)

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Hepatic Perfusion Therapy

Fri, 25 Mar 2016 15:35:28 +0100

Isolated hepatic perfusion uses the unique vascular supply of hepatic malignancies to deliver cytotoxic chemotherapy. The procedure involves vascular isolation of the liver and delivery of chemotherapy via the hepatic artery and extraction from retrohepatic vena cava. Benefits of hepatic perfusion have been observed in hepatic metastases of ocular melanoma and colorectal cancer and primary hepatocellular carcinoma. Percutaneous and prophylactic perfusions are avenues of ongoing research. (Source: Surgical Clinics of North America)

Second Malignancies After Radiotherapy for Prostate CancerSecond Malignancies After Radiotherapy for Prostate Cancer

Fri, 25 Mar 2016 14:34:21 +0100

Might irradiation of the prostate contribute to secondary cancers of other organs, such as bladder, colon, lung, and rectum? British Medical Journal (Source: Medscape Radiology Headlines)

Prognostic Relevance of the Peritoneal Surface Disease Severity Score Compared to the Peritoneal Cancer Index for Colorectal Peritoneal Carcinomatosis.

Fri, 25 Mar 2016 11:02:02 +0100

Conclusion. PCI is superior to PSDSS in predicting OS and PFS and remains the prognostic score of choice in CPC patients undergoing CRS/HIPEC. PMID: 27006828 [PubMed - in process] (Source: International Journal of Surgical Oncology)

Colon cancer screening: the devil is in the details.

Fri, 25 Mar 2016 05:09:03 +0100

Authors: Church J PMID: 27005881 [PubMed - in process] (Source: New Zealand Medical Journal)

Cancer-Associated Immune Resistance and Evasion of Immune Surveillance in Colorectal Cancer.

Fri, 25 Mar 2016 00:16:02 +0100

Authors: Parcesepe P, Giordano G, Laudanna C, Febbraro A, Pancione M Abstract Data from molecular profiles of tumors and tumor associated cells provide a model in which cancer cells can acquire the capability of avoiding immune surveillance by expressing an immune-like phenotype. Recent works reveal that expression of immune antigens (PDL1, CD47, CD73, CD14, CD68, MAC387, CD163, DAP12, and CD15) by tumor cells "immune resistance," combined with prometastatic function of nonmalignant infiltrating cells, may represent a strategy to overcome the rate-limiting steps of metastatic cascade through (a) enhanced interactions with protumorigenic myeloid cells and escape from T-dependent immune response mediated by CD8+ and natural killer (NK) cells; (b) production of immune mediators that e...

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The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

Fri, 25 Mar 2016 00:00:00 +0100

The prognostic value of lactate dehydrogenase levels in the prognosis of colorectal cancer patients has been assessed for years, although the results remain controversial and heterogeneous. Thus, we comprehens... (Source: BMC Cancer)

Phosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients

Fri, 25 Mar 2016 00:00:00 +0100

Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored t... (Source: Journal of Experimental and Clinical Cancer Research)

Transcriptional signature induced by a metastasis‐promoting c‐Src mutant in a human breast cell line

Thu, 24 Mar 2016 23:00:00 +0100

Deletions at the C‐terminus of the proto‐oncogene protein c‐Src kinase are found in the viral oncogene protein v‐Src as well as in some advanced human colon cancers. They are associated with increased kinase activity and cellular invasiveness. Here, we analyzed the mRNA expression signature of a constitutively active C‐terminal mutant of c‐Src, c‐Src(mt), in comparison with its wild‐type protein, c‐Src(wt), in the human non‐transformed breast epithelial cell line MCF‐10A. We demonstrated previously that the mutant altered migratory and metastatic properties. Genome‐wide transcriptome analysis revealed that c‐Src(mt) de‐regulated the expression levels of approximately 430 mRNAs whose gene products are mainly involved in the cellular processes of migration and adh...

Cancer Stage in American Indians and Alaska Natives Enrolled in Medicaid

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions In contrast to the general population of the U.S., among Medicaid enrollees, AI/AN race is not associated with later stage at diagnosis. Cancer survival disparities associated with AI/AN race that have been observed in the broader population may be driven by factors associated with income and health insurance that are also associated with race, as income and insurance status are more homogenous within the Medicaid population than within the broader population. (Source: American Journal of Preventive Medicine)

Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid

Thu, 24 Mar 2016 23:00:00 +0100

Publication date: 15 July 2016 Source:Journal of Molecular Structure, Volume 1116 Author(s): Miloš V. Nikolić, Marina Ž. Mijajlović, Verica V. Jevtić, Zoran R. Ratković, Slađana B. Novaković, Goran A. Bogdanović, Jelena Milovanović, Aleksandar Arsenijević, Bojana Stojanović, Srećko R. Trifunović, Gordana P. Radić The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) a...

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Solid cancer incidence among Chinese medical diagnostic x‐ray workers, 1950–1995: Estimation of radiation‐related risks

Thu, 24 Mar 2016 23:00:00 +0100

The objective of this study was to estimate solid cancer risk attributable to long‐term, fractionated occupational exposure to low doses of ionizing radiation. Based on cancer incidence for the period 1950–1995 in a cohort of 27,011 Chinese medical diagnostic X‐ray workers and a comparison cohort of 25,782 Chinese physicians who did not use X‐ray equipment in their work, we used Poisson regression to fit excess relative risk (ERR) and excess absolute risk (EAR) dose–response models for incidence of all solid cancers combined. Radiation dose reconstruction was based on a previously published method that relied on simulating measurements for multiple X‐ray machines, workplaces and working conditions, information about protective measures, including use of lead aprons, and work hi...

Unbiased identification of substrates of protein tyrosine phosphatase ptp-3 in C. elegans

Thu, 24 Mar 2016 23:00:00 +0100

The leukocyte antigen related (LAR) family of receptor-like protein tyrosine phosphatases has three members in humans – PTPRF, PTPRD and PTPRS – that have been implicated in diverse processes including embryonic development, inhibition of cell growth and axonal guidance. Mutations in the LAR family are associated with developmental defects such as cleft palate as well as various cancers including breast, neck, lung, colon and brain. Although this family of tyrosine phosphatases are important for many developmental processes, little is known of their substrates. (Source: Molecular Oncology)

Body mass index and the risk of cancer incidence in patients with type 2 diabetes in Japan: Results from the National Center Diabetes Database

Thu, 24 Mar 2016 23:00:00 +0100

ConclusionsThe findings of this study were limited by the relatively small number of patients in the cohort, which posed a danger of not finding significance. However, the results suggested that obesity did not become an additional risk factor for cancer in Japanese type 2 diabetic patients.This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)

Cancer Family: The Search for the Cause of Hereditary Colorectal Cancer

Thu, 24 Mar 2016 23:00:00 +0100

It has been stated that the best literature is the recording of one’s own experiences. Cancer Family is an exceptional example of such literature. The book combines personal and family experience with professional growth, scientific inquiry, and the excitement of scientific discovery. The story derives from the experience of the author, whose family was plagued with cancer. With appropriate detail and intensity, the writer describes the emotional trials of this unspoken family curse, the personal decision to address the family secret, and the long and winding road of endeavor toward a solution. (Source: Gastroenterology)

New Quality Measure Will Disincentivize Endoscopic Resection of Most Important Colorectal Lesions

Thu, 24 Mar 2016 23:00:00 +0100

Ranasinghe et al1 report a new facility measure for colonoscopy quality based on the rate of unplanned hospital visits within 7 days of outpatient colonoscopy. We have clinical and methodologic concerns about the effect of this measure on colorectal cancer prevention and procedural risk. (Source: Gastroenterology)

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Association between sexually transmitted disease and church membership. A retrospective cohort study of two Danish religious minorities

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions The cohort shows significant lower incidence of STD, most likely including human papillomavirus, which may partly explain the lower incidence of cancers of the cervix, rectum, anus, head and neck. (Source: BMJ Open)

Validity of ICD-9-CM codes for breast, lung and colorectal cancers in three Italian administrative healthcare databases: a diagnostic accuracy study protocol

Thu, 24 Mar 2016 23:00:00 +0100

The objective of this protocol is to assess the accuracy of International Classification of Diseases Ninth Revision—Clinical Modification (ICD-9-CM) codes for breast, lung and colorectal cancers in identifying patients diagnosed with the relative disease in three Italian administrative databases. Methods and analysis Data from the administrative databases of Umbria Region (910 000 residents), Local Health Unit 3 of Napoli (1 170 000 residents) and Friuli-Venezia Giulia Region (1 227 000 residents) will be considered. In each administrative database, patients with the first occurrence of diagnosis of breast, lung or colorectal cancer between 2012 and 2014 will be identified using the following groups of ICD-9-CM codes in primary position: (1) 233.0 and (2) 17...

A 31-day time to surgery compliant exercise training programme improves aerobic health in the elderly

Thu, 24 Mar 2016 23:00:00 +0100

Conclusions It is possible to improve cardiorespiratory fitness in 31 days in individuals of comparable age to those presenting for CRC surgery. (Source: Techniques in Coloproctology)

Laparoscopic resection of transverse colon cancer at splenic flexure: technical aspects and results

Thu, 24 Mar 2016 23:00:00 +0100

Abstract Laparoscopic resection of transverse colon cancer at splenic flexure is technical demanding and its efficacy remains controversial. The aim of this study was to investigate its technical aspects such as pitfalls and overcoming them, and to demonstrate the short-term and oncologic long-term outcomes. To overcome the difficulty in laparoscopic resection of transverse colon cancer at splenic flexure, we recognized the following technical tips as essential. First of all, we have to precisely identify major vessels variations feeding tumor. Secondary, anatomical dissection of mesocolon through medial approach is indispensible. Third, safe takedown of splenic flexure to fully mobilization of left hemicolon is mandatory. This cohort study analyzed 95 patients with stage II (43) ...

Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer.

Thu, 24 Mar 2016 23:00:00 +0100

Authors: Haque A, Alam Q, Alam MZ, Azhar EI, Sait KH, Anfina N, Mushtaq G, Kamal MA, Rasool M Abstract Heat Shock Protein 90 (HSP90) is a ubiquitous molecular chaperone that is considered to be the most abundantly expressed protein in various human cancers such as breast, lung, colon, prostate, leukemia and skin. The master regulator, HSP90 plays a pivotal role in the conformational stabilization, maturation and activity of its various labile oncogenic client proteins such as p53, ErbB2, Bcr-Abl, Akt, Her-2, Cdk4, Cdk6, Raf-1 and v-Src in altered cells. Hence, making a guaranteed attempt to inhibit such a master regulator for cancer therapy appears to be a potential approach for combinatorial inhibition of numerous oncogenic signaling pathways simultaneously. Considerable efforts a...

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5th Annual Walk/Run to Benefit Colon Cancer Education, Research

Thu, 24 Mar 2016 20:43:33 +0100

UR Medicine’s Division of Gastroenterology and Hepatology will sponsor the 5th annual Strollin’ for the Colon 5K Walk/Run beginning at 10 a.m. on Saturday, May 7, at the Village Park, Main St., Geneseo. (Source: University of Rochester Medical Center Press Releases)

This Disease Can Still Get You Quarantined For Months -- And It's On The Rise

Thu, 24 Mar 2016 17:08:03 +0100

In August 2014, Kate O’Brien, a 34-year-old media producer from Brooklyn, found out she was expecting her second child. She was ecstatic. But this pregnancy didn't proceed like the first. For the next few months, O'Brien had a cold she couldn't shake. She woke up in the middle of the night drenched in sweat. She wanted to blame it on her pregnancy, yet she kept losing weight. She could barely eat. She coughed up balls of bloody mucus. Her throat burned. None of her doctors could figure out what was wrong. A physician sent her to Mount Sinai West Hospital in Manhattan in January 2015, when, at five months pregnant, she still couldn't gain any weight. "No one likes a skinny pregnant lady," she said. O'Brien expected to stay at the hospital overnight. She didn’t get a chance to sa...

Analgesic use and risk of renal cell carcinoma: A case‐control, cohort, and meta‐analytic assessment

Thu, 24 Mar 2016 14:14:03 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)

Family caregiving challenges in advanced colorectal cancer: patient and caregiver perspectives

Thu, 24 Mar 2016 14:13:52 +0100

Conclusions Findings suggest that eliciting the perspectives of both patients and caregivers regarding caregivers’ challenges provides a more comprehensive understanding of their experience. Results also point to the need to assist caregivers with the emotional and practical aspects of caregiving. (Source: Supportive Care in Cancer)

Efficacy of venlafaxine for the relief of taxane and oxaliplatin-induced acute neurotoxicity: a single-center retrospective case–control study

Thu, 24 Mar 2016 14:13:52 +0100

Conclusion Venlafaxine has a significant clinical activity against taxane-oxaliplatin-induced acute neurosensory toxicity. (Source: Supportive Care in Cancer)

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The value of reasons for encounter in early detection of colorectal cancer.

Thu, 24 Mar 2016 13:17:02 +0100

Conclusion Data capture and organization in ICPC permits study of the predictive value of RFE for CRC in primary care.[Box: see text]. PMID: 27003276 [PubMed - as supplied by publisher] (Source: European Journal of General Practice)

Current Options for Third-Line Treatment of Metastatic Colorectal Cancer: Discussion.

Thu, 24 Mar 2016 12:15:01 +0100

Discussion. Clin Adv Hematol Oncol. 2016 Mar;14 Suppl 3(3):13-15 Authors: Grothey A, Marshall JL, Seery TE PMID: 27007241 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)

Management of Metastatic Colorectal Cancer in the Community-Based Setting.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Seery TE, Tran P PMID: 27007240 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)

Recent Clinical Trials in Relapsed/Refractory Metastatic Colorectal Cancer.

Thu, 24 Mar 2016 12:15:01 +0100

Authors: Marshall JL PMID: 27007238 [PubMed - as supplied by publisher] (Source: Clinical Advances in Hematology and Oncology)

Time course analysis based on gene expression profile and identification of target molecules for colorectal cancer

Thu, 24 Mar 2016 00:00:00 +0100

The study aimed to investigate the expression changes of genes in colorectal cancer (CRC) and screen the potential molecular targets. (Source: Cancer Cell International)

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Case report: mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance

Thu, 24 Mar 2016 00:00:00 +0100

Anti-programmed death-1 therapy has poor efficacy in mismatch repair-proficient (pMMR) colorectal cancers; however, its efficacy in pMMR gastric cancers remains undetermined. Here, we report the case of a pati... (Source: Journal of Hematology and Oncology)

Metastasis: The tumour microenvironment drives metastasis

Wed, 23 Mar 2016 23:00:00 +0100

Nature Reviews Cancer 16, 199 (2016). doi:10.1038/nrc.2016.31 Author: Gemma K. Alderton Mlecnik et al. analysed the genetics, levels of genomic instability, vascularization and the immunoscore (a measure of the 'immune contexture' of the tumour microenvironment) in a cohort of colorectal cancers. They found that FBXW7 mutations were inversely correlated with metastasis; genomic instability did (Source: Nature Reviews Cancer)

Asian Consensus on the relationship between Obesity and Gastrointestinal and Liver Diseases

Wed, 23 Mar 2016 23:00:00 +0100

ConclusionThese experts’ consensus on obesity and GI diseases in Asia form the basis for further research, and its translation into addressing this emerging issue. This article is protected by copyright. All rights reserved. (Source: Journal of Gastroenterology and Hepatology)

Hospital Variation in Anastomotic Leakage After Rectal Cancer Surgery in the Spanish Association of Surgeons Project: The Contribution of Hospital Volume

Wed, 23 Mar 2016 23:00:00 +0100

Conclusion Anastomotic leak varies significantly among hospitals included in the project and this difference cannot be attributed to the annual surgical volume. (Source: Cirugia Espanola)

Coffee consumption and the risk of cancer in the Norwegian Women and Cancer (NOWAC) Study

Wed, 23 Mar 2016 23:00:00 +0100

In this study, coffee consumption was associated with a modest reduced risk of cancer at any site. Residual confounding due to smoking may have contributed to the positive association between high coffee consumption and the risk of lung cancer. (Source: European Journal of Epidemiology)

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Genomic Characterization and Comparison of Multi-Regional and Pooled Tumor Biopsy Specimens

Wed, 23 Mar 2016 23:00:00 +0100

In conclusion, sequencing pooled samples has the benefit of detecting many variants with moderate allele frequency that occur in partial regions, but it is not applicable for detecting low-frequency mutations that require deep sequencing. (Source: PLoS One)

β‐lactoglobulin–pectin Nanoparticle‐based Oral Drug Delivery System for Potential Treatment of Colon Cancer

Wed, 23 Mar 2016 23:00:00 +0100

Colon cancer is one of the most common internal malignancies, and conventional chemotherapy is not effective in its treatment. Nanoparticles hold tremendous potential as an effective drug delivery system. The physicochemical properties of β‐lactoglobulin, the main whey protein of cow's milk, such as its stability at low pH, its resistance to gastric protease, and its ability to bind hydrophobic ligands, give it potential for transporting drugs specifically for colon cancer. In the present research, β‐lactoglobulin–pectin nanoparticles were designed to transfer a newly synthesized, anticancer platinum complex (bipyridine ethyl dithiocarbamate Pt(II) nitrate), to the colon. The effects of multiple factors on the size and the colloidal stability of the nanoparticles were studied using...

Edge density based automatic detection of inflammation in colonoscopy videos

Wed, 23 Mar 2016 23:00:00 +0100

Colon cancer is one of the deadliest diseases where early detection can prolong life and can increase the survival rates. The early stage disease is typically associated with polyps and mucosa inflammation. The often used diagnostic tools rely on high quality videos obtained from colonoscopy or capsule endoscope. The state-of-the-art image processing techniques of video analysis for automatic detection of anomalies use statistical and neural network methods. In this paper, we investigated a simple alternative model-based approach using texture analysis. (Source: Computers in Biology and Medicine)

Manipulation of the gut microbiota using resistant starch is associated with protection against colitis-associated colorectal cancer in rats

Wed, 23 Mar 2016 23:00:00 +0100

This study evaluated whether dietary resistant starch (RS) and green tea extract (GTE), which have anti-inflammatory and anticancer properties, protect against colitis-associated colorectal cancer (CAC) using a rat model, also investigated potential mechanisms of action of these agents including their effects on the gut microbiota. Rats were fed a control diet or diets containing 10% RS, 0.5% GTE or a combination of the two (RS + GTE). CAC was initiated with 2 weekly azoxymethane (AOM) injections (10mg/kg) followed by 2% dextran sodium sulphate in drinking water for 7 days after 2 weeks on diets. Rats were killed 20 weeks after the first AOM. Colon tissues and tumours were examined for histopathology by H&E, gene/protein expression by PCR and immunohistochemistry and digesta for analys...

An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis

Wed, 23 Mar 2016 23:00:00 +0100

This study explored its role as an anticancer agent. The AR seed extract (AR extract) inhibited proliferation and colony formation in a dose- and time-dependent manner and promoted apoptosis as was evidenced by cleavage of PARP and increased expression of Bax accompanying reduced levels of BCL-xl protein in HCT116 and SW480 cells, respectively. In addition, AR extract-arrested cells at Go/G1 phase of cell cycle and exhibited decreases in Cyclin D1. AR extract-treated cells exhibited reduced number and size of colonospheres in a dose-dependent manner concomitant with decreases in cancer stem cell (CSC) markers ALDH1A1 and Dclk1. Relative levels of β-catenin, Notch-ICD, Hes1 and EZH2 were also attenuated by AR extract. TOP-flash reporter activity, a measure of Wnt signaling, decreased s...

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Phase I dose escalation study of temsirolimus in combination with metformin in patients with advanced/refractory cancers

Wed, 23 Mar 2016 23:00:00 +0100

Conclusions Combination temsirolimus/metformin was well tolerated with modestly promising effectiveness among this heavily pretreated patient cohort. We recommend a dose of temsirolimus 25 mg weekly and metformin 2000 mg daily for phase II study. (Source: Cancer Chemotherapy and Pharmacology)

Prospective study of dietary phytoestrogen intake and the risk of colorectal cancer.

Wed, 23 Mar 2016 23:00:00 +0100

Authors: Hedelin M, Löf M, Sandin S, Adami HO, Weiderpass E Abstract Dietary phytoestrogen intake has been inversely associated with the risk of prostate and breast cancer and might also affect the risk of colorectal cancer. We evaluated the associations between dietary lignan intake, dietary isoflavonoid intake, dietary coumestrol intake, and dietary enterolignans and equol intake, and risk of colorectal cancer. Data from the Women's Lifestyle and Health (WLH) Cohort study was used. The WLH study is a prospective population-based cohort study including 48,268 Swedish women aged 30-49 years at the time of enrolment in 1991-92. Follow-up for colorectal cancer incidence, death, and emigration until the end of 2010 was performed through record linkage to the Swedish Cancer Registry ...

Mechanisms of colorectal cancer

Wed, 23 Mar 2016 21:34:15 +0100

Chang J, Huang L, Cao Q, Liu F (Source: OncoTargets and Therapy)

Pioneering Colorectal Cancer Research

Wed, 23 Mar 2016 19:11:00 +0100

(Source: American Cancer Society :: News and Features)

RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy

Wed, 23 Mar 2016 19:08:07 +0100

This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)

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Early Diagnosis Vital for Early Onset CRCEarly Diagnosis Vital for Early Onset CRC

Wed, 23 Mar 2016 18:59:30 +0100

At the Second Annual Early Age Onset Colorectal Cancer Summit, experts, family, and survivors emphasized the need for improved diagnosis. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)

Tanshinone IIA enhances chemosensitivity of colon cancer cells by suppressing nuclear factor-κB.

Wed, 23 Mar 2016 14:45:02 +0100

In conclusion, these results suggest that TSA induces cell death and chemosensitizes colon cancer cells through the suppression of NF-κB signaling. PMID: 26998041 [PubMed - as supplied by publisher] (Source: Experimental and Therapeutic Medicine)

Laparoscopic versus open surgery for T4 colon cancer: evaluation of margin status

Wed, 23 Mar 2016 06:34:36 +0100

Conclusions Using this large national surgical database, select patients with T4 lesions who underwent planned laparoscopic colorectal resections did not have a significantly higher positive margin rate compared with patients with open operations. Further research is needed to identify the role of laparoscopy in managing T4b lesions before any consensus can be reached regarding its application in locally advanced colon cancer. (Source: Surgical Endoscopy)

Cetuximab as First-line Treatment for Metastatic Colorectal Cancer: Caution With Interpretation of Cost-Effectiveness Results Toward Medical Decision Making

Wed, 23 Mar 2016 00:15:31 +0100

No abstract available (Source: American Journal of Clinical Oncology)