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Sat, 19 Mar 2016 10:10:02 +0100Authors: Cervellin G, Sanchis-Gomar F, Lippi G Abstract INTRODUCTION: Although anaphylaxis is a relatively common disorder, clinicians and scientists have debated on how to best define and manage this condition. Although the current recommendations are focused on the central role of adrenaline, evidence in support of this therapeutic approach is modest, mainly for the lack of well-designed trials. Conversely, serious adverse effects are commonly reported following adrenaline use, especially when given intravenously. These include hypertension, ventricular arrhythmias, myocardial infarction, pulmonary edema. Areas covered. Anaphylaxis treatment, with special focus on adrenaline utilization, both in pre-hospital and in-hospital settings. Aim is to examine in depth the balance between...
Sat, 19 Mar 2016 06:34:47 +0100[Abstract unavailable] Language: en... (Source: SafetyLit)
Thu, 17 Mar 2016 00:00:00 +0100We present one such case of ranitidine-induced perioperative anaphylaxis which was successfully managed by early diagnosis and avoidance of drug. (Source: Indian Journal of Pharmacology)
Wed, 16 Mar 2016 00:00:00 +0100Authors: Vongphoumy I, Chanthilat P, Vilayvong P, Blessmann J Abstract Snakebites are a seriously neglected public health problem in Lao PDR. Community-based cross-sectional surveys in two districts of Savannakhet province in Southern Laos revealed an incidence of up to 1105 snakebites per 100,000 persons per year. In contrast the number of snakebite patients treated in district and provincial hospitals are low. In order to improve health care for snakebite victims, antivenom was introduced to Savannakhet provincial hospital in July 2013 and medical staff has been trained in management of venomous snakebites at the same time. After the intervention the number of snakebite patients treated at the provincial hospital increased significantly from 4 patients in 2012 to 158 snakebite pa...
Tue, 15 Mar 2016 00:00:00 +0100CONCLUSIONSSubjects with a negative test result can be safely treated with cetuximab. Further research is required regarding the optimal cutoff for positivity and the positive predictive value. Cancer 2016. © 2016 American Cancer Society. (Source: Cancer)
Tue, 15 Mar 2016 00:00:00 +0100We present a 15-year-old female patient with an anaphylactic reaction to a jellyfish sting, sustained while surfing in the Mediterranean Sea. She experienced immediate difficulty in breathing, hoarseness and itching and was taken by ambulance to the emergency department, receiving intramuscular adrenaline on the way. She presented with periorbital swelling and facial edema and improved with systemic steroids and antihistamines. She was discharged 2 days later with allergy service follow up at our institution. This is the first case report documenting anaphylaxis due to Mediterranean jellyfish envenomation. (Source: Toxicology Reports)
Sat, 12 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Sat, 12 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. PMID: 26973062 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Fri, 11 Mar 2016 11:34:42 +0100Conclusions: Ferumoxytol was overall well tolerated among 49 pediatric and 19 young adult patients experiencing various tumors or kidney transplants without major adverse events or signs of hematologic and kidney impairment or liver toxicity. Larger studies are needed to determine the incidence of anaphylactic reactions. (Source: Investigative Radiology)
Fri, 11 Mar 2016 00:00:00 +0100Publication date: Available online 11 March 2016 Source:Journal of Forensic and Legal Medicine Author(s): Nicholas G. Kounis, George D. Soufras, George N. Kounis, Dimitrios Lianas, Nicholas Patsouras (Source: Journal of Forensic and Legal Medicine)
Fri, 11 Mar 2016 00:00:00 +0100Cystic echinococcosis (CE), caused by infection with Echinococcus granulosus larvae, is a potentially life-threatening disease in humans. Anaphylactic shock caused by CE is very dangerous, and is highly prevalent... (Source: BMC Immunology)
Thu, 10 Mar 2016 16:57:02 +0100Authors: Wang YM, Du GQ Abstract Glycyrrhizic acid has a variety of biological properties, including a protective function in the liver, and anti‑inflammatory, anti‑ulcer, anti‑anaphylaxis, anti‑oxidant, immunoregulatory, antiviral and anticancer activities. The efficacy of glycyrrhizic acid can be increased when combined with other medicines. In the present study, the potential protective effects of glycyrrhizic acid against enteritis in rats, and its role in regulating anti‑inflammation, anti‑oxidation, angiogenic and apoptotic mechanisms were investigated using enzyme‑linked immunosorbent and bicinchoninic acid assays, and reverse transcription‑quantitative polymerase chain reaction and western blotting analyses. Adult male Sprague‑Dawley rats were injected wit...
Thu, 10 Mar 2016 00:00:00 +0100CONCLUSIONS: The present study provides evidence that cornuside inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression. Furthermore, in vivo and in vitro anti-allergic effects of cornuside suggest a possible therapeutic application of this agent in inflammatory allergic diseases. PMID: 26972254 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)
Wed, 09 Mar 2016 15:15:06 +0100Conclusion: This preliminary study showed that epinephrine can be significantly absorbed via the IN route in humans. However, it requires a higher IN dose (5 mg) than the usual IM dose (0.3 mg) to achieve comparable systemic epinephrine absorption.humans. However, it requires a higher IN dose (5 mg) than the usual IM dose (0.3 mg) to achieve comparable systemic epinephrine absorption. (Source: Asian Pacific Journal of Allergy and Immunology)
Wed, 09 Mar 2016 11:19:22 +0100Conclusions: Our immunological approach enabled us to fully characterize the sensitization pattern of 6 sesame seed-allergic patients. The different protein composition of commercially available allergen extracts influences the outcomes of the immunological assays and thus also the diagnosis to a large extent.Int Arch Allergy Immunol 2016;169:13-22 (Source: International Archives of Allergy and Immunology)
Wed, 09 Mar 2016 11:19:22 +0100Conclusion: Most of the children with suspected NBL do not have true hypersensitivity. The frequency of confirmed hypersensitivity is low, and thus a detailed history should be taken from patients with suspected NBL hypersensitivity and DPTs should be performed in patients without contraindications.Int Arch Allergy Immunol 2016;169:45-50 (Source: International Archives of Allergy and Immunology)
Tue, 08 Mar 2016 00:00:00 +0100Conclusion A significant number of patients with food-triggered AD may develop immediate-type reactions. Strict elimination diets need to be thoughtfully prescribed as they may lead to decreased oral tolerance. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Tue, 08 Mar 2016 00:00:00 +0100Conclusion Cor a 14 was found to be a useful and reliable tool for predicting clinical reactivity in children with hazelnut allergy in the Eastern Mediterranean area. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Tue, 08 Mar 2016 00:00:00 +0100Conclusions Anaphylaxis due to cholinergic triggers is underreported, with only several case reports in the literature. Reactions are multisystem with cutaneous, upper and lower airway, and cardiovascular involvement in most patients. Manifestations may be life-threatening, and reactions are often severe. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Tue, 08 Mar 2016 00:00:00 +0100Publication date: March–April 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 4, Issue 2 Author(s): David González-de-Olano, Jose M. Morgado, Raquel Juárez-Guerrero, Laura Sánchez-Muñoz, Javier Letellez-Fernández, Diego Malón-Giménez, Mariana C. Castells (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Tue, 08 Mar 2016 00:00:00 +0100Authors: Plaza-Martin AM Abstract The concept of allergic reaction currently includes all those where an immunological reaction depends on a reaction mediated by IgE, as well as those that involve other immune mechanisms, such as T-cell regulators. There are many different clinical situations, like the classic immediate reactions (IgE mediated) such as urticaria, angioedema, immediate vomiting, abdominal pain, both upper respiratory (aphonia or rhinitis) and lower (wheezing or dyspnoea) symptom, and cardiovascular symptoms. The reactions that involve more than one organ, such as anaphylaxis, which could be an anaphylactic shock if there is cardiovascular involvement. The clinical signs and symptoms produced by non-IgE mediated reactions are usually more insidious in how they start,...
Mon, 07 Mar 2016 13:30:00 +0100Conclusion This was a follow-up study of a well-designed randomised controlled trial. The original study found the early introduction of regular small amounts of peanut protein to infants at high risk of having peanut allergy reduced the proportion that developed a peanut allergy by the age of five, compared with avoiding peanuts completely. The latest study found that even if the children who had been exposed to peanuts then avoided them for 12 months, this did not significantly increase their likelihood of developing a peanut allergy. Strengths of the study include the use of objective tests to determine how well the children managed to avoid peanuts, as well as a questionnaire. The group who avoided peanuts during the trial were better at avoiding them during follow-up, and this m...
Sun, 06 Mar 2016 00:00:00 +0100We examined if children an... (Source: Allergy, Asthma and Clinical Immunology)
Sat, 05 Mar 2016 00:00:00 +0100Conclusions RDD is cost effective and safe for allergic patients with cancer and chronic disease to remain on first line therapy. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Sat, 05 Mar 2016 00:00:00 +0100Conclusion Cor a 14 was found to be a useful and reliable tool for predicting clinical reactivity in children with hazelnut allergy in the Eastern Mediterranean area. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Sat, 05 Mar 2016 00:00:00 +0100Publication date: Available online 21 January 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Inês Mota, Ângela Gaspar, Marta Chambel, Mário Morais-Almeida (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Sat, 05 Mar 2016 00:00:00 +0100Publication date: Available online 12 January 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Sophie Roenneberg, Alexander Böhner, Knut Brockow, Alexander Arnold, Ulf Darsow, Bernadette Eberlein, Tilo Biedermann (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Sat, 05 Mar 2016 00:00:00 +0100Discussion SIACI of mannitol followed by Cetuximab (up to 250 mg/m2) for recurrent malignant glioma is safe and well tolerated. A Phase I/II trial is currently underway to determine the efficacy of SIACI of cetuximab in patients with high-grade glioma. (Source: Journal of Neuro-Oncology)
Sat, 05 Mar 2016 00:00:00 +0100Even though allergen immunotherapy is an effective treatment method that has been used on rhinitis, asthma and venom anaphylaxis for over 100 years, systemic reactions (SRs) limit the use of this treatment method. We classified SRs associated with subcutaneous immunotherapy (SCIT) according to the World Allergy Organisation Subcutaneous Immunotherapy Systemic Reaction Grading System. Risk factors for the SRs were assessed. (Source: International Journal of Pediatric Otorhinolaryngology)
Wed, 02 Mar 2016 00:00:00 +0100Publication date: April 2016 Source:Molecular Immunology, Volume 72 Author(s): Frank Bantleon, Sara Wolf, Henning Seismann, Svend Dam, Andrea Lorentzen, Michaela Miehe, Frederic Jabs, Thilo Jakob, Melanie Plum, Edzard Spillner TH2-biased immunity to parasites and allergens is often associated with increased levels of antigen-specific and high affinity IgE. The role in reacting against minute amounts of target structures and to provoke severe anaphylactic reactions renders IgE a mechanistically outstanding isotype. IgE represents the least abundant serum antibody isotype and exhibits a variety of peculiarities including structure, extensive glycosylation and effector functions. Despite large progress in antibody technologies, however, the recombinant access to isotypes beyond Ig...
Wed, 02 Mar 2016 00:00:00 +0100Soumi Pathak, Mamta Dubey, Nitesh GoelIndian Journal of Anaesthesia 2016 60(3):215-216 (Source: Indian Journal of Anaesthesia)
Wed, 02 Mar 2016 00:00:00 +0100Conclusion Our findings indicate that herbal medicines for oral use carry a risk of causing immediate allergy-like ADRs. Studies using the Vigibase® database can identify specific combinations of particular herbs and adverse reactions. Healthcare professionals and patients should be aware of these risks and report any serious adverse experiences. (Source: Drug Safety)
Tue, 01 Mar 2016 15:40:02 +0100Authors: Kim S, Lee JM Abstract Leukotriene receptor antagonists, which are generally considered safe with a few adverse drug reactions, are increasingly used in the treatment of various allergic diseases, including asthma and allergic rhinitis. Although a few anaphylactic reactions to montelukast have been reported worldwide, there is still a lack of reports about severe adverse drug reactions associated with pranlukast. Here, we report a case of severe hypersensitivity reaction associated with pranlukast. A 65-year-old woman developed anaphylactic shock that presented as generalized urticaria, angioedema, collapse, and loss of consciousness after receiving pranlukast. A positive response to oral challenge and skin prick testing with pranlukast was observed in the patient. In this...
Tue, 01 Mar 2016 15:40:02 +0100CONCLUSIONS: The antibody and cytokine levels induced by OVA in BALB/c mice and the observation that BALB/c spleen cell cultures were more resistant than those of C3H/HeOuJ mice to the stimulus of LPS make this strain prone to exhibit Th2-mediated food allergic reactions and very adequate for the study of the features of OVA that make it allergenic. PMID: 26922934 [PubMed - as supplied by publisher] (Source: Allergy, Asthma and Immunology Research)
Tue, 01 Mar 2016 15:37:02 +0100ANAPHYLAXIS GUIDELINE-TRIGGERS AND PRE-HOSPITAL CARE. Arerugi. 2016;65(1):18-21 Authors: Ito K PMID: 26923649 [PubMed - as supplied by publisher] (Source: Allergology International)
Tue, 01 Mar 2016 14:14:02 +0100CONCLUSIONS: Our study shows that most recommendations were fully or partially followed and may need reminding, but many points need to be completed or updated with new tools and knowledge acquired during the last 10 years. PMID: 26925131 [PubMed - as supplied by publisher] (Source: Archives of Medical Science)
Tue, 01 Mar 2016 00:00:00 +0100Authors: Kobayashi Y, Sato H, Yorita M, Nakayama H, Miyazato H, Sugimoto K, Jippo T Abstract We investigated the effects of geranium essential oil (GEO) on anaphylaxis. GEO can exert antioxidant and anti-inflammatory effects, but its roles in allergic reactions are incompletely understood. Here, we used mouse cells to show that GEO inhibited the degranulation of cultured mast cells (CMCs). Citronellol is the major component of GEO and inhibited CMC degranulation. The l-enantiomer of citronellol more effectively suppressed CMC degranulation than did d-citronellol. We also examined whether citronellol could inhibit the immunoglobulin (Ig) E-induced production of tumor necrosis factor (TNF)-α. Treatment with various concentrations of citronellol before CMC activation with IgE signifi...
Tue, 01 Mar 2016 00:00:00 +0100During IgE-mediated immediate hypersensitivity reactions, vascular endothelial cells permeabilize in response to mast cell mediators. We have demonstrated previously that patients and mice with signal transducer and activator of transcription 3 (STAT3) mutations (autosomal dominant hyper-IgE syndrome [AD-HIES]) are partially protected from anaphylaxis. (Source: Journal of Allergy and Clinical Immunology)
Tue, 01 Mar 2016 00:00:00 +0100The potential for anaphylaxis to Hymenoptera stings is well known. Anaphylaxis often occurs after a number of uneventful prior stings.1 In the United States, a Hymenoptera sting can lead to a systemic allergic reaction in 3% of adults and accounts for more deaths than any other envenomation.1 Thromboembolic stroke associated with Hymenoptera venom–induced anaphylaxis has not been documented in the literature. (Source: Annals of Allergy, Asthma and Immunology)
Tue, 01 Mar 2016 00:00:00 +0100We read with great interest the 2015 update of the anaphylaxis practice parameter by Lieberman and colleagues.1 Several aspects of this update are particularly relevant to clinicians in emergency medicine, especially the sections on “Office Management of Anaphylaxis” and “Controversies and Unsettled Issues Related to Patients at Risk for or Being Treated for Anaphylaxis.” However, we believe that there are also several issues included in the update that require clarification based on the current literature. (Source: Annals of Allergy, Asthma and Immunology)
Tue, 01 Mar 2016 00:00:00 +0100During our journal club today, we read with appreciation and enthusiasm the anaphylaxis practice parameter published in the November issue of the Annals.1 We noted 3 typographical errors. (Source: Annals of Allergy, Asthma and Immunology)
Tue, 01 Mar 2016 00:00:00 +0100Authors: Parekh H, Patel A, Godhwani N PMID: 26945501 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Tue, 01 Mar 2016 00:00:00 +0100Authors: Alqurashi W, Alnaji F, Menon K PMID: 26945499 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Tue, 01 Mar 2016 00:00:00 +0100Authors: Johnson JA, Frith JA, Casselman J, Saad A, Tcheurekdjian H, Hostoffer R PMID: 26945498 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)
Tue, 01 Mar 2016 00:00:00 +0100Authors: Roe C, Anderson N, Frew A, Tarzi M PMID: 26961453 [PubMed - in process] (Source: British Journal of Hospital Medicine)
Tue, 01 Mar 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Mon, 29 Feb 2016 06:34:10 +0100ABSTRACT: The aim of this study was to investigate the time interval between radiocontrast media (RCM) administration and the development of anaphylactic shock, and risk factors associated with RCM-induced anaphylactic shock. We reviewed the medical records of 154 patients with RCM-induced anaphylaxis presenting to the emergency department of a tertiary care hospital between January 2005 and December 2014. Clinical features of RCM-induced anaphylaxis were analyzed, and patients were categorized into shock and non-shock groups to identify associated factors in affected patients. Of the 154 cases of RCM-induced anaphylaxis, 101 (65.9%) patients experienced shock. The median time between RCM exposure and the onset of shock was 11 min (interquartile range, 7.0–18.8). In patients with RCM-ind...
Sat, 27 Feb 2016 00:00:00 +0100We report a case in which a child with very high-risk ALL having experienced severe anaphylaxis with pegaspargase was later successfully treated with palifermin during stem cell transplant conditioning. (Source: Journal of Oncology Pharmacy Practice)
Fri, 26 Feb 2016 22:34:52 +0100Purpose of review: Anaphylaxis is a systemic allergic reaction that can be life-threatening or fatal and can result from work-related exposures. This review study focuses on the assessment, main triggers, and management of occupational anaphylaxis. Recent findings: Exposed workers can be sensitized through inhalation and skin contact, and the risks increase with penetration of the allergen through the skin. The main eliciting agents of occupational anaphylaxis include stinging insects and animal bites, natural rubber latex and other vegetable allergens, food products, and drugs. Workers sensitized to occupational allergens may also develop anaphylaxis outside the work environment from exposure to the same or to cross-reacting allergens. Cofactors at work such as exercise may increase the ...
Fri, 26 Feb 2016 00:00:00 +0100ConclusionThere is a risk of anaphylactic reaction with extensively hydrolyzed formulas via residual cow's milk peptides. Skin prick test to extensively hydrolyzed formula should be performed before prescription of extensively hydrolyzed formulasThis article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Fri, 26 Feb 2016 00:00:00 +0100Conclusions— Our results support the idea that the IV use of US contrast agents in children is safe, feasible, diagnostically robust, and effective. (Source: Journal of Ultrasound in Medicine)
Thu, 25 Feb 2016 00:00:00 +0100Polymyxin B–trimethoprim eye drops are commonly used to treat bacterial conjunctivitis in the pediatric population. Although allergic reactions to polymyxin, such as contact dermatitis, from topical antimicrobial applications have been reported, to our knowledge no prior literature has documented a case of anaphylaxis after the administration of eye drops that contain polymyxin.1–3 In this letter, we describe a case of a systemic anaphylactic response to polymyxin B–trimethoprim eye drops. (Source: Annals of Allergy, Asthma and Immunology)
Thu, 25 Feb 2016 00:00:00 +0100Authors: Henao MP, Ghaffari G PMID: 26922212 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Wed, 24 Feb 2016 22:16:38 +0100For most people with an allergy, a reaction normally means watery eyes, sneezing, a rash, and other mild symptoms. For others, however, being exposed to an allergen can be a life-threatening event. We define something as an allergy when the body's immune system responds to a normally benign substance as though it were harmful. Allergic symptoms often include sneezing, nasal congestion, wheezing, eye redness, skin rashes, and itching. For many allergy sufferers, these are the worst symptoms they will experience and can manage them with avoidance, medications, and education. For other people, however, exposure to allergens can lead to a severe and life-threatening allergic reaction known as anaphylaxis. Anaphylaxis affects more than one area of the body at the same time and often begins soon...
Wed, 24 Feb 2016 00:00:00 +0100Peanut allergy (PA) affects approximately 1% to 1.5% of children and adults living in westernized society1 and is considered a life-long allergy in the vast majority of subjects.2,3 Additionally, peanuts and tree nuts account for 90% of all cases of fatal and near-fatal anaphylaxis to foods.4 Strict dietary avoidance and availability of injectable epinephrine are key management tools in the current food allergy guidelines,2 and the quest for effective allergen immunotherapy for PA is ongoing.5 (Source: Journal of Allergy and Clinical Immunology)
Wed, 24 Feb 2016 00:00:00 +0100In a process known as overt degranulation, mast cells can release all at once a diverse array of products that are preformed and present within cytoplasmic granules. This occurs typically within seconds of stimulation by environmental factors and allergens. These potent, preformed mediators (i.e. histamine, heparin, serotonin and serine proteases) are responsible for the acute symptoms experienced in allergic conditions such as allergic conjunctivitis, allergic rhinitis, allergy-induced asthma, urticaria and anaphylaxis. (Source: Translational Research)
Wed, 24 Feb 2016 00:00:00 +0100Authors: Koppelman SJ, Jayasena S, Luykx D, Schepens E, Apostolovic D, de Jong GA, Isleib TG, Nordlee J, Baumert J, Taylor SL, Cheng H, Maleki S Abstract Four different market classes of peanut (Runner, Virginia Spanish, and Valencia) are commonly consumed in Western countries, but for some consumers peanuts are a main cause of food-induced anaphylaxis. Limited information is available on the comparative allergenicity of these distinct market classes. The aim of this study was to compare allergenicity attributes of different peanut cultivars. The protein content and protein profiles were highly comparable for all tested cultivars. All cultivar samples contained the major allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6, as assessed by SDS-PAGE and RP-HPLC, although some minor differ...
Tue, 23 Feb 2016 00:00:00 +0100In this study, we identified five structural mimotopes of the major cat allergen Fel d 1 by immunoscreening with random peptide phage libraries. The mimotopes were computationally mapped to the allergen surface, and their IgE reactivity was confirmed using sera from cat-allergic patients. Importantly, the mimotopes showed no basophil activation of the corresponding cat-allergic patients, which makes them good candidates for the development of hypoallergenic vaccine. As bacteriophage particles are becoming increasingly recognized as immunogenic carriers, we constructed bacteriophage particles displaying multiple copies of each selected mimotope on major phage coat protein. These constructed phages elicited T cell-mediated immune response, which was predominated by the type 1 T cell response...
Mon, 22 Feb 2016 00:00:00 +0100Authors: Rahkila J, Panchadhayee R, Ardá A, Jiménez-Barbero J, Savolainen J, Leino R Abstract People suffering from allergies can be treated with repeated injections of increasing amounts of a specific allergen. This type of specific immunotherapy is currently the only way to treat the underlying pathological immune response associated with an allergy. The approach can afford long-lasting protection, but the process takes 3-5 years, can produce allergic reactions, and in severe cases treatment is often aborted due to anaphylaxis. However, treatment can be optimized with the use of specific adjuvants that modify the immune response, its duration, and that increase the production of the correct type of antibodies. In the pursuit of such adjuvants, two new trivalent acetylated β-(1...
Sat, 20 Feb 2016 18:49:37 +0100Conclusions: The sensitivity of both the direct and passive HRT for diagnosing patients with immediate allergy to CLV is less than 60%. However, the passive HRT has the advantage that it is based on the testing of serum samples that can be handled more easily than fresh blood samples.Int Arch Allergy Immunol 2015;168:233-240 (Source: International Archives of Allergy and Immunology)
Sat, 20 Feb 2016 18:49:37 +0100Conclusion: We report a novel adjuvant-free mouse model of SF allergy with robust quantifiable and correlated readouts of allergenicity that may be used in basic biomedical, preclinical and applied food/nutrition research on SF allergy.Int Arch Allergy Immunol 2015;168:269-276 (Source: International Archives of Allergy and Immunology)
Sat, 20 Feb 2016 00:00:00 +0100Conclusion RGE may be a useful therapeutic agent for the treatment of allergic inflammatory diseases such as AD-like dermatitis. (Source: Journal of Ginseng Research)
Fri, 19 Feb 2016 00:00:00 +0100Conclusions and Clinical RelevanceHigh‐dose cutaneous exposure to dust mites induced effective blocking IgG production, even if accompanied by IgE production. Our data might support the concept that an increase in IgG titer, not a decrease in IgE titer, is a marker of clinical improvement in allergen‐specific immunotherapy.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Thu, 18 Feb 2016 06:09:02 +0100Management of angioedema without urticaria in the emergency department. Ann Med. 2014 Dec;46(8):607-18 Authors: Pedrosa M, Prieto-García A, Sala-Cunill A, Spanish Group for the Study of Bradykinin-Mediated Angioedema (SGBA) and the Spanish Committee of Cutaneous Allergy (CCA) Abstract Angioedema refers to a localized, transient swelling of the deep skin layers or the upper respiratory or gastrointestinal mucosa. It develops as a result of mainly two different vasoactive peptides, histamine or bradykinin. Pathophysiology, as well as treatment, is different in each case; nevertheless, the resulting signs and symptoms may be similar and difficult to distinguish. Angioedema may occur at any location. When the affected area involves the upper respiratory tract, both forms ...
Thu, 18 Feb 2016 00:00:00 +0100We report a rare case of aortitis with ostial occlusion and left ventricular failure in secondary syphilis. Her management required a true multidisciplinary approach from multiple specialities due to complications of concomitant psychosis and a history of anaphylaxis to penicillin. This case illustrates the complexities of diagnosing and managing a rare presentation of this increasingly prevalent infection. (Source: Sexually Transmitted Infections)
Thu, 18 Feb 2016 00:00:00 +0100Conclusions: The AERs associated with SA has been described. Though the MAUDE database is not an exact, wholesome and reliable source to identify the potential AER, currently, it is the only available source of AERs associated with SA use. The nature of AERs with the use of SA and its potential pathogenesis and implications has been discussed. (Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3))
Thu, 18 Feb 2016 00:00:00 +0100We present the results of the second safety analysis. In addition to the standard analyses for hematological and non-hematological toxicities, any affections of the cranial nerves as well as the rate of macula degenerations and anaphylactic reactions are of special interest.Results: Between 09/2012 and 05/2015 a total of 1473 patients have been randomized (EnPC n=734; dtEC-dtD n=739). Among those, 84 patients have been included in the trastuzumab substudy. No safety data are currently available for the substudy. Median age was 52 years and median body-mass-index 26. In terms of hematological adverse events, the rate of febrile neutropenia grade 3-4 (12% vs. 8%) and thrombopenia grade 3-4 (12% vs. 5%) was significantly increased in the EnPC arm. As for non-hematological side effects, there ...
Wed, 17 Feb 2016 14:28:02 +0100Authors: Gawlik R, Glück J, Jawor B, Rogala B Abstract Hymenoptera venoms are known to cause life-threatening IgE-mediated anaphylactic reactions in allergic individuals. Venom immunotherapy is a recommended treatment of insect allergy with still the mechanism not being completely understood. We decided to assess the serum CCL5/RANTES level in patients who experienced severe anaphylactic reaction to Hymenoptera venom and to find out changes in the course of immunotherapy. Twenty patients (9 men, 11 women, mean age: 31.91 ± 7.63 years) with history of anaphylactic reaction after insect sting were included into the study. Diagnosis was made according to sIgE and skin tests. All of them were enrolled into rush venom immunotherapy with bee or wasp venom extracts (Pharmalgen, ALK-...
Wed, 17 Feb 2016 14:28:02 +0100Authors: Lee B, Kim EY, Kim JH, Min JH, Jeong DW, Jun JY, Cho CY, Sohn Y, Jung HS Abstract Peiminine is the main biologically active component derived from Fritillaria ussuriensis. Peiminine was investigated in various pulmonary diseases, but its antiallergic effect and the related mechanism have not been reported yet. The present study aimed to evaluate the effect of peiminine on mast cell-mediated allergic inflammation in HMC-1 cells. The pro-inflammatory cytokine production was measured using ELISA, reverse transcription-polymerase chain reaction and nuclear factor-kappaB (NF-κB), mitogen-activated protein kinases (MAPKs) pathway activation, as determined by Western blot analysis. Peiminine inhibits the production of the pro-inflammatory cytokine, such as interleukin (IL)-6, IL...
Wed, 17 Feb 2016 14:28:02 +0100This study shows damnacanthal inhibits the NF-κB/receptor-interacting protein-2/caspase-1 signal pathway by inhibiting p56lck tyrosine kinase and suggests that damnacanthal has potential for the treatment of mast cell-mediated allergic disorders. PMID: 25139491 [PubMed - indexed for MEDLINE] (Source: Immunopharmacology and Immunotoxicology)
Wed, 17 Feb 2016 14:28:02 +0100CONCLUSION: These data suggest that the direct inhibition of Th1 and Th2 activation by anti-ovalbumin monoclonal IgA participates in the inhibition of the primary antibody responses. IgA plays important immunosuppressive roles under physiological and pathological conditions and is a promising candidate drug for the treatment of immune disorders. PMID: 25077632 [PubMed - indexed for MEDLINE] (Source: Immunopharmacology and Immunotoxicology)
Wed, 17 Feb 2016 14:27:02 +0100Authors: Quirce S, Boyano-Martínez T, Díaz-Perales A Abstract IgE-mediated allergy to wheat proteins can be caused by exposure through ingestion, inhalation, or skin/mucosal contact, and can affect various populations and age groups. Respiratory allergy to wheat proteins is commonly observed in adult patients occupationally exposed to flour, whereas wheat food allergy is more common in children. Wheat allergy is of growing importance for patients with recurrent anaphylaxis, especially when exercise related. The diagnosis of wheat allergy relies on a consistent clinical history, skin prick testing with well-characterized extracts and specific IgE tests. The accuracy of wheat allergy diagnosis may be improved by measuring IgE responses to several wheat components. However, a high d...
Wed, 17 Feb 2016 14:27:02 +0100Authors: Ventura MT, Scichilone N, Gelardi M, Patella V, Ridolo E Abstract The number of people over 65 is increasing around the world. At present, between 5 and 10% of allergic diseases affect the elderly. In particular, rhinitis is increasing worldwide; the presence of high comorbidity makes the therapy of asthma even more complicated. With reference to dermatological allergies, the dryness of the skin favors the onset of allergic contact and atopic dermatitis, while the senescence of mucous membranes and the impaired secretion of polymeric IgA could be linked to food allergy. Overcoming the problem of adverse drug reaction is limited by the diagnostic difficulty in patients taking multiple drugs. In addition, some drugs, such as β-blockers, angiotensin-converting enzyme (ACE)-i...
Wed, 17 Feb 2016 00:00:00 +0100ConclusionsThe study supports the use of self‐efficacy scale to identify specific areas where teachers’ confidence in their ability to care for food‐allergic students is especially weak. This would empower the development of training programs specifically tailored to the needs of teachers and caregivers.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Wed, 17 Feb 2016 00:00:00 +0100Publication date: Available online 16 February 2016 Source:Orthopaedics & Traumatology: Surgery & Research Author(s): N.G. Kounis, G.D. Soufras (Source: Orthopaedics and Traumatology: Surgery and Research)
Mon, 15 Feb 2016 00:00:00 +0100Case (Source: The American Journal of Emergency Medicine)
Mon, 15 Feb 2016 00:00:00 +0100Conclusions Intraperitoneal administration of PTX from the day of gastrectomy did not result in a higher incidence of surgical complications and adverse reactions when compared with intravenous administration of PTX. (Source: Gastric Cancer)
Sun, 14 Feb 2016 19:09:04 +0100CONCLUSIONS: Parents and children preferred a combination of in-person meetings and Internet support to enhance the capacity of children, reduce children's anxiety, increase their self-care skills, and self-confidence. In addition they believed a support intervention was a stepping stone to developing a community of support for children with asthma, allergies, and anaphylaxis. PMID: 21568624 [PubMed - indexed for MEDLINE] (Source: Issues in Comprehensive Pediatric Nursing)
Sun, 14 Feb 2016 14:58:02 +0100Authors: Carrillo E, Hern HG, Barger J Abstract Anaphylaxis in the pediatric population is both serious and potentially lethal. The incidence of allergic and anaphylactic reactions has been increasing and the need for life saving intervention with epinephrine must remain an important part of Emergency Medical Services (EMS) provider training. Our aim was to characterize dosing and timing of epinephrine, diphenhydramine, and albuterol in the pediatric patient with anaphylaxis. In this retrospective chart review, we studied prehospital medication administration in pediatric patients ages 1 month up to 14 years old classified as having a severe allergic reaction or anaphylaxis. We compared rates of epinephrine, diphenhydramine, and albuterol given to patients with allergic conditions...
Sat, 13 Feb 2016 00:00:00 +0100In this study, the multiple anti-allergic effects of both substances by simultaneous treatment were examined in order to determine if they could further mitigate allergic symptoms. Concurrent treatment with nobiletin and β-lactoglobulin effectively suppressed de-granulation of RBL-2H3 cells by inhibiting increases in intracellular Ca2+ concentration. Immunoblot analysis showed that phosphorylation of phosphoinositide 3-kinase, Akt, and Syk in RBL-2H3 cells was all inhibited by the concurrent presence of nobiletin and β-lactoglobulin. Moreover, concurrent administration of nobiletin and β-lactoglobulin reduced passive cutaneous anaphylaxis (PCA) reaction in mice compared with nobiletin or β-lactoglobulin administered alone. In addition, the concurrent administration of freeze-dried Citr...
Fri, 12 Feb 2016 00:00:00 +0100CONCLUSIONS: Overall, the quality of the evidence was low. The low quality was mainly due to the differing results between studies, lack of blinding in some studies, and relatively few studies reporting participant-centred outcome measures. We found limited evidence that SIT may be an effective treatment for people with AE. The treatments used in these trials were not associated with an increased risk of local or systemic reactions. Future studies should use high quality allergen formulations with a proven track record in other allergic conditions and should include participant-reported outcome measures. PMID: 26871981 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Fri, 12 Feb 2016 00:00:00 +0100(Source: PEDIATRICS)
Thu, 11 Feb 2016 04:39:01 +0100In conclusion, the most hymenoptera stings induced local swelling only; severe reactions were rare. The most dangerous stings are enoral and result from inattentive drinking. Epinephrine was rarely used in anaphylactic reactions. PMID: 26859128 [PubMed - in process] (Source: Swiss Medical Weekly)
Thu, 11 Feb 2016 00:00:00 +0100Conclusion Performance of stress CMR is safe in a referral population. Inducible ischaemia was the only factor identified which was associated with serious complications. The incidence of non-severe complications and minor symptoms was greater with dobutamine. (Source: European Heart Journal Cardiovascular Imaging)
Tue, 09 Feb 2016 18:33:02 +0100Authors: Mota I, Pereira AM, Pereira C, Tomaz E, Ferreira MB, Sabino F, Coelho A, Santos A, Martins H, Morais-Almeida M Abstract Anaphylaxis has a growing incidence, especially in children. It represents a medical emergency and its successful therapy depends on early and proper intervention. Intramuscular epinephrine, with dose adjustment according to weight and age, is the drug of choice for anaphylaxis treatment. After resolution of the acute reaction, the patient should be kept under clinical surveillance for 6 to 24 hours, due to possible biphasic reactions. Prescription of an epinephrine auto injectable device should be considered in all patients with diagnosed or suspected anaphylaxis; additionally these patients should always be referred to an Immunoallergy consultation, to ...
Mon, 08 Feb 2016 00:00:00 +0100ConclusionsThe incidence of allergic reactions leading to hospitalizations between 1999 and 2011 increased in Finland and Sweden among children aged 0 to 19 years. In Finland, the incidence was lower throughout the study period compared to Sweden. Younger children constituted the majority of hospitalized children. (Source: Allergy)
Mon, 08 Feb 2016 00:00:00 +0100Publication date: Available online 8 February 2016 Source:Respiratory Medicine Case Reports Author(s): Tomohisa Nakamura, Takeshi Ogo, Akihiro Tsuji, Shigefumi Fukui, Tetsuya Fukuda, Nobuhiro Tahara, Yoshihiro Fukumoto, Satoshi Yasuda, Hisao Ogawa, Norifumi Nakanishi A 28-year-old male was referred to our hospital with dyspnea. He was diagnosed as having chronic thromboembolic pulmonary hypertension, and a pulmonary endarterectomy (PEA) was performed. However, exertional dyspnea remained because of residual pulmonary hypertension; therefore, the patient was re-admitted to our hospital 1 year after PEA. We performed computed tomography and pulmonary angiography and found web and band lesions in the distal pulmonary artery with a high pulmonary artery pressure. Although further m...
Mon, 08 Feb 2016 00:00:00 +0100Every year, snake-bites kill more than 100,000 people, while survivors suffer physical and mental sequelae; insects cause over 5000 anaphylactic deaths, scorpion-stings kill more than 1000 and spiders and jellyfish kill hundreds. Aquatic venomous animals include sea-snakes, fish, jellyfish, corals, cone shells, blue-ringed octopuses and sea urchins. Specific antidotes – hyperimmune serum antivenoms – are manufactured for serious envenoming. Adrenaline (epinephrine) is essential treatment for anaphylaxis. (Source: Medicine)
Mon, 08 Feb 2016 00:00:00 +0100Abstract For half a century, it has been known that the mast cell is the cell responsible for the majority of anaphylactic events. Its mediators, taken as a whole, are capable of producing all of the clinical manifestations of these events. With the discovery of immunoglobulin E (IgE), it was originally felt that the vast majority of anaphylactic episodes were due to antigen coupling with two cell-bound IgE molecules. More recently it has been learned that many episodes are produced by direct activation of mast cells, not involving antigen binding to IgE, and that monomeric IgE under certain conditions can also cause degranulation. Of note—in regard to antigen independent degranulation—are recent reports that the human G-protein-coupled receptor, MRGPRX2, may be the receptor ...
Mon, 08 Feb 2016 00:00:00 +0100Abstract Skin prick testing is the diagnostic procedure for allergies and is considered to be safe. It is usually performed using the prick and the prick‐to‐prick method. Herein is described a pediatric case of anaphylaxis during prick‐to‐prick testing with raw fish in a patient who had consumed fish without any systemic allergic reactions beforehand, to illustrate that skin prick testing should be carefully planned and performed with caution in order to avoid potentially serious risks for the patient. (Source: Pediatrics International)
Sun, 07 Feb 2016 00:00:00 +0100Publication date: 15 June 2016 Source:Biosensors and Bioelectronics, Volume 80 Author(s): Elaine Ng, Kari C. Nadeau, Shan X. Wang Current common allergen detection methods, including enzyme-linked immunosorbent assays (ELISAs) and dip-stick methods, do not provide adequate levels of sensitivity and specificity for at-risk allergic patients. A method for performing highly sensitive and specific detection of multiple food allergens is thus imperative as food allergies are becoming increasingly recognized as a major healthcare concern, affecting an estimated 4% of the total population. We demonstrate first instance of sensitive and specific multiplexed detection of major peanut allergens Ara h 1 and Ara h 2, and wheat allergen Gliadin using giant magnetoresistive (GMR) sensor arrays. Com...
Sat, 06 Feb 2016 20:04:27 +0100ConclusionsIn contrast to conventional PLA2 subcutaneous immunotherapy, the therapeutic administration of PLA2‐MB treatment to mice that already had established allergy to PLA2 protects all subsequently challenged animals.This article is protected by copyright. All rights reserved. (Source: Allergy)
Fri, 05 Feb 2016 00:00:00 +0100Conclusions hucMSC exosomes are well tolerated in animal models. This study provides evidence for the safety of intravenous infusion in future clinical therapy. (Source: Cytotherapy)
Thu, 04 Feb 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Thu, 04 Feb 2016 00:00:00 +0100This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Thu, 04 Feb 2016 00:00:00 +0100CONCLUSION: More than half of women allergic to penicillin without anaphylaxis received an antibiotic other than penicillin or cefazolin as prophylaxis, indicating poor adherence to national guidelines. PMID: 26855111 [PubMed - as supplied by publisher] (Source: Obstetrics and Gynecology)
Wed, 03 Feb 2016 00:00:00 +0100We report a case of insulin allergy due to intradermal insulin injections which was cured by adopting a proper injection technique. (Source: Diabetes Therapy)
Tue, 02 Feb 2016 00:00:00 +0100Conclusion The results indicate that the hemolytic assaying method is not only suitable for prediagnostic assaying of hemolytic ADR of herbal medicine injection, but also partly reflects the anaphylaxis of herbal injections, and tannins may be the major factors causing abnormal hemolysis. (Source: Chinese Herbal Medicines)
Mon, 01 Feb 2016 06:00:00 +0100Abstract: Taking care of children with autism spectrum disorders is not uncommon in emergency departments as they visit hospital for acute medical and psychiatric conditions. The current prevalence and increasing incidence of autism spectrum disorders will increase the demand for hospital and outpatient services for these children, necessitating education of health care professionals and system adaptations. This paper describes a patient with autism spectrum disorder who had some challenging behavior in the emergency department when he presented with anaphylaxis and discusses management strategies that would help in caring for children with autism spectrum disorders. (Source: Pediatric Emergency Care)
Mon, 01 Feb 2016 06:00:00 +0100CONCLUSION: True IgE-mediated anaphylaxis to local anesthesia is very rare. Dermatologic surgeons should be aware of the symptoms of anesthetic allergy and its mimickers, as well as how to manage allergic reactions in their clinical practice. (Source: Dermatologic Surgery)