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MedWorm: Allergy



MedWorm.com provides a medical RSS filtering service. Over 7000 RSS medical sources are combined and output via different filters. This feed contains the latest news and research in the Allergy category.



Last Build Date: Tue, 22 Mar 2016 08:30:00 +0100

 



Update on Immunotherapy for the Treatment of AsthmaUpdate on Immunotherapy for the Treatment of Asthma

Tue, 22 Mar 2016 05:13:25 +0100

What does the latest research tell us about the use of allergen immunotherapy for asthma? Current Opinion in Pulmonary Medicine (Source: Medscape Allergy Headlines)

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Off-Label Uses of Topical Calcineurin InhibitorsOff-Label Uses of Topical Calcineurin Inhibitors

Tue, 22 Mar 2016 05:13:25 +0100

Studies show that topical calcineurin inhibitors may be effective in treating a variety of skin conditions, and as an alternative to long-term topical corticosteroids. What's the latest evidence? Skin Therapy Letter (Source: Medscape Allergy Headlines)



Endotypes of Pollen Food Syndrome in Children with Seasonal Allergic Rhinoconjunctivitis: a molecular classification

Tue, 22 Mar 2016 05:13:18 +0100

ConclusionsIn a Mediterranean country characterized by multiple pollen exposures, PFS is a complex and frequent complication of childhood SAR, with five distinct endotypes marked by peculiar profiles of IgE sensitization to panallergens. Prospective studies in cohorts of PFS patients are now required to test whetherthis novel classification may be useful for diagnostic and therapeutic purposes in the clinical practice.This article is protected by copyright. All rights reserved. (Source: Allergy)



Exercise Prescriptions for Chronic Conditions: A How-to GuideExercise Prescriptions for Chronic Conditions: A How-to Guide

Tue, 22 Mar 2016 04:41:21 +0100

A new guide seeks to increase physicians' awareness about the effectiveness of different types of exercise in the treatment of specific chronic diseases. Medscape Medical News (Source: Medscape Allergy Headlines)



Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review

Tue, 22 Mar 2016 00:00:00 +0100

Conclusion The findings from this review will be used to inform the development of recommendations for EAACI’s Guidelines on AIT. (Source: Clinical and Translational Allergy)



FDA proposes ban on powdered gloves

Mon, 21 Mar 2016 22:57:32 +0100

The Food and Drug Administration has proposed a ban on most powdered gloves used during surgery and for patient examination, and on absorbable powder used for lubricating surgeons’ gloves. Aerosolized glove powder on natural rubber latex gloves can cause respiratory allergic reactions, and while... (Source: Skin and Allergy News)

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FDA Proposes Ban of Powdered Medical GlovesFDA Proposes Ban of Powdered Medical Gloves

Mon, 21 Mar 2016 22:35:55 +0100

A ban of powdered gloves for surgery and patient exams would not create a glove shortage, given the ascendancy of powderless alternatives, the agency said. News Alerts (Source: Medscape Allergy Headlines)



Feds launch phase 2 of HIPAA audits

Mon, 21 Mar 2016 21:59:01 +0100

The federal government has launched the second phase of its HIPAA Audit Program and will soon be identifying health providers it plans to target. For the 2016 Phase 2 HIPAA Audit Program, auditors will review policies and procedures enacted by covered entities and their business associates to... (Source: Skin and Allergy News)



CMS announces application schedule for Next Gen ACOs

Mon, 21 Mar 2016 21:21:08 +0100

Organizations looking to become a next generation accountable care organization (ACO) must have their letter of intent to apply submitted to the Centers for Medicare & Medicaid Services by May 2. This deadline represents the second and final round of applications the agency is accepting to... (Source: Skin and Allergy News)



Low vitamin D linked with worse outcome in melanoma

Mon, 21 Mar 2016 20:00:00 +0100

Lower levels of vitamin D in patients with melanoma were associated with poorer survival, independent of effects from systemic inflammation indicated by simultaneous C-reactive protein (CRP) measures, according to researchers. Multivariate analysis showed that vitamin D level was associated with... (Source: Skin and Allergy News)



DNA markers link season of birth, allergy risk

Mon, 21 Mar 2016 15:03:15 +0100

The season a person is born in influences a wide range of things: from risk of allergic disease, to height and lifespan. Yet little is known about how a one-time exposure like the season of birth has such lasting effects. Researchers have now discovered specific markers on DNA that link the season of birth to risk of allergy in later life. (Source: ScienceDaily Headlines)

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Rosacea linked to increased Parkinson’s disease risk

Mon, 21 Mar 2016 15:00:00 +0100

Individuals with rosacea were nearly twice as likely to develop Parkinson’s disease as those without rosacea, based on an analysis of results of a nationwide cohort study of 5.4 million people conducted in Denmark. The findings were published online March 21 in JAMA Neurology. Data from previous... (Source: Skin and Allergy News)



Severe Allergies and Travel: The Journey Begins With a Single StepSevere Allergies and Travel: The Journey Begins With a Single Step

Mon, 21 Mar 2016 14:45:17 +0100

With severe allergies increasing, travel-related allergy incidents are on the rise. Physicians are key in advising patients on the steps they can take to mitigate the risk for reactions. Medscape Allergy & Immunology (Source: Medscape FamilyMedicine Headlines)



Blooming Trees Can Bring Misery to Allergy Sufferers

Mon, 21 Mar 2016 12:46:37 +0100

But expert offers tips on how to keep symptoms under control Source: HealthDay Related MedlinePlus Pages: Allergy, Hay Fever (Source: MedlinePlus Health News)



Cobalt allergy: suitable test concentration, and concomitant reactivity to nickel and chromium

Mon, 21 Mar 2016 12:05:04 +0100

ConclusionsCobalt chloride 1% pet. is more suitable for patch testing than 0.5%. Solitary cobalt allergy is as frequent as concomitant allergy to cobalt and nickel or chromium. Sources of skin exposure to metals need to be identified for prevention of contact allergy. This is, owing to large knowledge gaps, particularly demanding for cobalt. (Source: Contact Dermatitis)



Blooming Trees Can Bring Misery to Allergy Sufferers

Mon, 21 Mar 2016 07:00:00 +0100

Title: Blooming Trees Can Bring Misery to Allergy SufferersCategory: Health NewsCreated: 3/20/2016 12:00:00 AMLast Editorial Review: 3/21/2016 12:00:00 AM (Source: MedicineNet Allergies General)

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SINUS AND ALLERGY PE (Chlorpheniramine Maleate And Phenylephrine Hcl) Tablet [Better Living Brands, LLC]

Mon, 21 Mar 2016 05:00:00 +0100

Updated Date: Mar 21, 2016 EST (Source: DailyMed Drug Label Updates)



CHILDRENS ALLERGY (Fexofenadine Hydrochloride) Suspension [Topco Associates LLC]

Mon, 21 Mar 2016 05:00:00 +0100

Updated Date: Mar 21, 2016 EST (Source: DailyMed Drug Label Updates)



ALLERGY (Diphenhydramine Hcl) Tablet, Coated [FRED'S, INC.]

Mon, 21 Mar 2016 05:00:00 +0100

Updated Date: Mar 21, 2016 EST (Source: DailyMed Drug Label Updates)



CHILDRENS ALLERGY (Loratadine) Liquid [Dolgencorp, Inc. (DOLLAR GENERAL REXALL)]

Mon, 21 Mar 2016 05:00:00 +0100

Updated Date: Mar 21, 2016 EST (Source: DailyMed Drug Label Updates)



ALLERGY RELIEF-D24 HOUR 24 HOUR (Loratadine And Pseudoephedrine Sulfate) Tablet, Extended Release [Topco Associates LLC]

Mon, 21 Mar 2016 05:00:00 +0100

Updated Date: Mar 21, 2016 EST (Source: DailyMed Drug Label Updates)

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DNA markers link season of birth and allergy risk

Mon, 21 Mar 2016 04:00:00 +0100

(University of Southampton) Researchers at the University of Southampton have discovered specific markers on DNA that link the season of birth to risk of allergy in later life. (Source: EurekAlert! - Medicine and Health)



Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately. (Source: Journal of Medical Genetics)



Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal akinesia

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions We provide the first description of a human phenotype that appears to result from MYOD1 mutation. The presentation with FADS is consistent with a large body of data demonstrating that in the mouse, MyoD is a major controller of precursor cell commitment to the myogenic differentiation programme. (Source: Journal of Medical Genetics)



Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy

Mon, 21 Mar 2016 00:00:00 +0100

Conclusions Our findings establish MFF loss of function as a cause of disturbed mitochondrial and peroxisomal dynamics associated with early-onset Leigh-like basal ganglia disease. We suggest that, even if laboratory findings are not indicative of mitochondrial or peroxisomal dysfunction, the co-occurrence of optic and/or peripheral neuropathy with seizures warrants genetic testing for MFF mutations. (Source: Journal of Medical Genetics)



Allergenicity assessment strategy for novel food proteins and protein sources

Mon, 21 Mar 2016 00:00:00 +0100

Publication date: Available online 21 March 2016 Source:Regulatory Toxicology and Pharmacology Author(s): Kitty Verhoeckx, Henrike Broekman, André Knulst, Geert Houben To solve the future food insecurity problem, alternative and sustainable protein sources (e.g. insects, rapeseed, fava bean and algae) are now being explored for the production of food and feed. To approve these novel protein sources for future food a comprehensive risk assessment is needed according to the European food legislation. Allergenicity risk assessment might pose some major difficulties, since detailed guidance on how to assess the allergenic potential of novel foods is not available. At present, the approach relies mostly on the guidance of allergenicity assessment for genetically modified (GM) plant foods...

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Prevalence and cumulative incidence of food hypersensitivity in the first ten years of life

Mon, 21 Mar 2016 00:00:00 +0100

ConclusionsBy the age of ten years 6.8% of children suffered from FHS based on food challenges and a good clinical history. There was a large discrepancy between reported and diagnosed FHS.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)



Editorial Board

Mon, 21 Mar 2016 00:00:00 +0100

(Source: Allergy)



Table of Contents

Mon, 21 Mar 2016 00:00:00 +0100

(Source: Allergy)






Asthma during pregnancy and congenital malformations: The challenging task of separating the medication effect from asthma itself

Mon, 21 Mar 2016 00:00:00 +0100

We have read with interest the article by Garne et al1 which adds new information on the impact of asthma treatments during pregnancy on the prevalence of congenital malformations. The study concluded that the use of inhaled β2-agonists (short- and long-acting combined) is associated with an increased risk of cleft palate and gastroschisis, whereas the use of inhaled corticosteroids (ICSs) showed no increased risk for any of the examined malformations. We fear however that such a statement could negatively affect the confidence of clinicians and mothers in short-acting β2-agonists (SABAs), specifically salbutamol, which was the most frequently used β2-agonist in this study. (Source: Journal of Allergy and Clinical Immunology)

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Reply

Mon, 21 Mar 2016 00:00:00 +0100

We thank Eltonsy and Blais1 for their comments.2 (Source: Journal of Allergy and Clinical Immunology)



The “Jewelry Addict”: Allergic Contact Dermatitis from Repetitive Multiple Children's Jewelry Exposures

Mon, 21 Mar 2016 00:00:00 +0100

This article provides an overview of jewelry allergies and the potential allergens requiring screening. (Source: Pediatric Dermatology)



Blooming Trees Can Bring Misery to Allergy Sufferers

Sun, 20 Mar 2016 13:00:00 +0100

But expert offers tips on how to keep symptoms under control (Source: U.S. News - Health)



'Show-Me' Instruction Reduces COPD Inhaler Misuse (CME/CE)

Sun, 20 Mar 2016 02:35:00 +0100

(MedPage Today) -- Impact greatest in patients with low health literacy (Source: MedPage Today Allergy)

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Scurvy in the present times: vitamin c allergy leading to strict fast food diet.

Sun, 20 Mar 2016 01:46:01 +0100

Authors: Shaath T, Fischer R, Goeser M, Rajpara A, Aires D Abstract Scurvy results from a deficiency of vitamin C, a nutrient otherwise known as ascorbic acid. Today, scurvy is rare yet emerges inselect patients. The patient reported herein developed scurvy secondary to deliberate avoidance of vitamin C-rich foods. Classic cutaneous manifestations of scurvy include follicular hyperkeratosis and perifollicular hemorrhage encompassing coiled "corkscrew" hairs and hairs bent into "swan-neck" deformities. Ecchymoses, purpura, and petechiae are also characteristically prominent. Classic oral abnormalities include erythematous, swollen gingivae that hemorrhage from subtle microtrauma.Subungual linear splinter hemorrhages may also manifest as a sign of the disease.To establish the di...



Curvularia pallescens, a prevalent aerospore in India

Sun, 20 Mar 2016 00:00:00 +0100

Publication date: Available online 19 March 2016 Source:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics Author(s): Debarati Dey, Bodhisattwa Saha, Gaurab Sircar, Kavita Ghosal, Swati Gupta Bhattacharya The worldwide prevalence of fungal allergy in recent years has augmented mining allergens from yet unexplored ones. Curvularia pallescens (CP) being a dominant aerospore in India and a major sensitizer on a wide range of allergic population, pose a serious threat to human health. Therefore, we aimed to identify novel allergens from CP in our present study. A cohort of 22 CP-sensitised patients was selected by positive Skin prick grade. Individual sera exhibited elevated specific IgE level and significant histamine release on a challenge with antigenic extract of CP. Firs...



D.C. Week: Turing Execs Grilled Again in Senate Hearing

Sat, 19 Mar 2016 16:00:00 +0100

(MedPage Today) -- Also, Medicare advisors call current physician payment 'adequate' (Source: MedPage Today Allergy)



Renin angiotensin system blockers-associated angioedema in the Thai population

Sat, 19 Mar 2016 12:57:02 +0100

(Source: Asian Pacific Journal of Allergy and Immunology)



Ole e 13 is the unique food allergen in olive: structure-functional, substrates docking, and molecular allergenicity comparative analysis

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: Available online 17 March 2016 Source:Journal of Molecular Graphics and Modelling Author(s): J.C. Jimenez-Lopez, P. Robles-Bolivar, F.J. Lopez-Valverde, E. Lima-Cabello, S.O. Kotchoni, J.D. Alché Thaumatin-like proteins (TLPs) are enzymes with important functions in pathogens defense and in the response to biotic and abiotic stresses. Last identified olive allergen (Ole e 13) is a TLP, which may also importantly contribute to food allergy and cross-allergenicity to pollen allergen proteins. The goals of this study are the characterization of the structural-functionality of Ole e 13 with a focus in its catalytic mechanism, and its molecular allergenicity by extensive analysis using different molecular computer-aided approaches covering a) functional-regulatory mot...

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Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma

Sat, 19 Mar 2016 00:00:00 +0100

We have used a proteomic approach to identify novel mediators of inflammation in the sputum of a subject with asthma compared with a healthy control subject (see this article's MethodsE1,E2 section in the Online Repository at www.jacionline.org). Using this approach, we determined that follistatin-like 1 (FSTL1) is more than 200-fold highly expressed in the subject with asthma compared with the control subject and was the most highly expressed of the 508 proteins we examined in sputum. FSTL1, a 308 amino acid extracellular glycoprotein that shares 94% identity in man and mouse,1,2 is generated by nonhematopoietic cells such as cells of the mesenchymal lineage (fibroblasts, chondrocytes, osteocytes, adipocytes, cardiomyocytes) by stimuli including TGF-β, IL-1β, TNF-α, and IL-6. (Source: ...



Relationship between lung function and quantitative computed tomographic parameters of airway remodeling, air trapping, and emphysema in patients with asthma and chronic obstructive pulmonary disease: A single-center study

Sat, 19 Mar 2016 00:00:00 +0100

There is a paucity of studies comparing asthma and chronic obstructive pulmonary disease (COPD) based on thoracic quantitative computed tomographic (QCT) parameters. (Source: Journal of Allergy and Clinical Immunology)



Persistence of the IgE repertoire in birch pollen allergy

Sat, 19 Mar 2016 00:00:00 +0100

IgE plays a critical role during allergic inflammation by sensitizing mast cells and basophils. The number of IgE-expressing B cells and plasma cells is generally very low, and it is therefore difficult to directly study their development and homeostasis.1 The diversity and persistence of the human IgE repertoire is largely unknown (reviewed in Gadermaier et al2). IgE switching can occur directly (IgM=>IgE) or indirectly (IgM=>IgG1=>IgE in mice3 and IgM=>IgG1/IgG2/IgG3/IgG4=>IgE in humans4). Studies in mice revealed that indirect IgE switching is required for the generation of high-affinity IgE responses. (Source: Journal of Allergy and Clinical Immunology)



Airway smooth muscle enlargement is associated with protease-activated receptor 2/ligand overexpression in patients with difficult-to-control severe asthma

Sat, 19 Mar 2016 00:00:00 +0100

Asthma is a complex disease with heterogeneous features of airway inflammation and remodeling. The increase in airway smooth muscle (ASM) mass is an essential component of airway remodeling in patients with severe asthma, yet the pathobiological mechanisms and clinical outcomes associated with ASM enlargement remain elusive. (Source: Journal of Allergy and Clinical Immunology)



Multiple drug allergy

Sat, 19 Mar 2016 00:00:00 +0100

A 16-year-old nonatopic boy with recurrent tonsillitis was admitted to our drug safety clinic because of his history of drug allergy. More than 1 year before, he had an immediate hypersensitivity reaction after oral administration of amoxicillin. He developed rash, pruritus, and dyspnea 10 to 15 minutes after amoxicillin intake. Two months later, because of this adverse event, the patient began taking clarithromycin as an alternative, safe antibiotic. He developed general urticaria 30 minutes after intake. (Source: Annals of Allergy, Asthma and Immunology)

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Salivary cotinine measurement for all children with persistent asthma: spit matters

Sat, 19 Mar 2016 00:00:00 +0100

Despite awareness that secondhand smoke (SHS) exacerbates asthma symptoms, more than half of US children with asthma are exposed to SHS,1 and the parent is the primary source of exposure.2,3 Explanations for failure to prevent SHS exposure in the home for children with asthma are multifaceted and not well understood, and significant underreporting of SHS exposure occurs.4 Furthermore, few health care professionals use biomarkers (ie, cotinine) as an objective measure of SHS exposure.5 There has been minimal effort to examine the factors associated with persistent SHS exposure in high-risk children with asthma. (Source: Annals of Allergy, Asthma and Immunology)



Safety of chitosan processed wine in shrimp allergic patients

Sat, 19 Mar 2016 00:00:00 +0100

Wine is an ubiquitous product all over the world, but up to 1 in 10 consumers reports intolerance or allergy-like symptoms after drinking wine.1 Chitosan is a linear polysaccharide and the product of the deacetylation of chitin, the main component of the cell walls of some fungi; the exoskeletons of arthropods, such as crustaceans and insects; and the beaks of cephalopods.2 It also may be used in wine processing. (Source: Annals of Allergy, Asthma and Immunology)



Persistent Mycobacterium abscessus infection secondary to interferon-γ autoantibodies

Sat, 19 Mar 2016 00:00:00 +0100

We present a case of a woman with interferon-γ autoantibodies resulting in persistent Mycobacterium abscessus infection. (Source: Annals of Allergy, Asthma and Immunology)



Allergic Contact Dermatitis Due to Cosmetics: A Clinical and Epidemiological Study in a Tertiary Hospital

Sat, 19 Mar 2016 00:00:00 +0100

Publication date: Available online 19 March 2016 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): V. Zaragoza-Ninet, R. Blasco Encinas, J.J. Vilata-Corell, A. Pérez-Ferriols, C. Sierra-Talamantes, A. Esteve-Martínez, J. de la Cuadra-Oyanguren The incidence of allergic contact dermatitis (ACD) to cosmetics in the general population is rising with the increasing use of cosmetic products and their proliferation and diversification. The aims of this study were to determine the prevalence of ACD to cosmetics in our setting, analyze changes over time, describe the clinical and epidemiological features of this allergic reaction, and identify the allergens and cosmetics involved. We performed a prospective study at the skin allergy unit in Hospital General Universitario ...



Prevalence of sensitization to methylisothiazolinone in an italian skin allergy unit.

Fri, 18 Mar 2016 23:12:02 +0100

CONCLUSIONS: In Italy the prevalence of MI and MI/MCI contact allergy is alarmingly high and it is increasing. PMID: 26981911 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)

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Prevalence and risk factors of asthma in First Nations children living on reserves in Canada.

Fri, 18 Mar 2016 23:04:02 +0100

CONCLUSIONS: The overall prevalence of ever-asthma and factors associated with ever-asthma in First Nations children living on reserves were similar to those reported for off-reserve Aboriginal children and non-Aboriginal Canadian children. PMID: 26986908 [PubMed - as supplied by publisher] (Source: Canadian Journal of Public Health)



Match day 2016: Residency spots rise, but growth still needed

Fri, 18 Mar 2016 18:38:35 +0100

Medical school seniors scored a record number of available first-year slots in this year’s Main Residency Match, with both internal medicine and family medicine programs offering more spots to residents in 2016. (Source: Skin and Allergy News)



Contents Vol. 168, 2015

Fri, 18 Mar 2016 16:19:22 +0100

Int Arch Allergy Immunol 2015;168:I-IV (Source: International Archives of Allergy and Immunology)



Acknowledgement to the Reviewers

Fri, 18 Mar 2016 16:19:22 +0100

Int Arch Allergy Immunol 2015;168:285-287 (Source: International Archives of Allergy and Immunology)



Molecular diagnosis and precision medicine in allergy management

Fri, 18 Mar 2016 11:19:08 +0100

Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)

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HISTAMINUM 30C ALLERGY RELIEF (Histaminum Hydrochloricum) Pellet [Boiron]

Fri, 18 Mar 2016 05:00:00 +0100

Updated Date: Mar 18, 2016 EST (Source: DailyMed Drug Label Updates)



Comparison between IV immune globulin (IVIG) and anti‐D globulin for treatment immune thrombocytopenia: a randomized open‐label study

Fri, 18 Mar 2016 00:00:00 +0100

ConclusionOur results showed that anti‐D was associated with rapid rise of platelets compared to IVIG. In addition, anti‐D treatment had acceptable safety profile.This article is protected by copyright. All rights reserved. (Source: Fundamental and Clinical Pharmacology)



Endocytosis in enterocytes

Fri, 18 Mar 2016 00:00:00 +0100

Summary Endocytosis is a fundamental cell biological process, which carries out essential functions in a polarized epithelial cell such as enterocytes provided with a huge surface area of the brush border membrane. Major tasks of enterocytes, which are regulated by endocytic signals, are digestion and absorption of nutrients and drugs/pharmacological agents, barrier permeability to microorganism, toxins and antigens, and transcytotic crosstalk between intestinal lumen and lamina propria cells with access to the circulation. Investigations on inflammatory bowel diseases such as food allergy, celiac disease, Crohn’s disease, and ulcerative colitis focus on immune processes originating within enterocytes as antigen presenting cells. Thus the initiation of oral tolerance, t...



Empirical tuberculosis therapy versus isoniazid in adult outpatients with advanced HIV initiating antiretroviral therapy (REMEMBER): a multicountry open-label randomised controlled trial

Fri, 18 Mar 2016 00:00:00 +0100

Publication date: 19–25 March 2016 Source:The Lancet, Volume 387, Issue 10024 Author(s): Mina C Hosseinipour, Gregory P Bisson, Sachiko Miyahara, Xin Sun, Agnes Moses, Cynthia Riviere, Fredrick K Kirui, Sharlaa Badal-Faesen, David Lagat, Mulinda Nyirenda, Kogieleum Naidoo, James Hakim, Peter Mugyenyi, German Henostroza, Paul D Leger, Javier R Lama, Lerato Mohapi, Jorge Alave, Vidya Mave, Valdilea G Veloso, Sandy Pillay, Nagalingeswaran Kumarasamy, Jing Bao, Evelyn Hogg, Lynne Jones, Andrew Zolopa, Johnstone Kumwenda, Amita Gupta Background Mortality within the first 6 months after initiating antiretroviral therapy is common in resource-limited settings and is often due to tuberculosis in patients with advanced HIV disease. Isoniazid preventive therapy is rec...

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Reviewer acknowledgement 2015

Fri, 18 Mar 2016 00:00:00 +0100

(Source: Allergy, Asthma and Clinical Immunology)



From immunotoxicity to carcinogenicity: the effects of carbamate pesticides on the immune system.

Fri, 18 Mar 2016 00:00:00 +0100

Authors: Dhouib I, Jallouli M, Annabi A, Marzouki S, Gharbi N, Elfazaa S, Lasram MM Abstract The immune system can be the target of many chemicals, with potentially severe adverse effects on the host's health. In the literature, carbamate (CM) pesticides have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, some autoimmune diseases and cancers. CMs may initiate, facilitate, or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for immunoregulatory factors and modifying immune tolerance. In the present study, direct immunotoxicity, endocrine disruption and inhibition of esterases activities have been introduced as the main mecha...



Step-down therapy in well-controlled asthmatic patients

Thu, 17 Mar 2016 21:57:23 +0100

Horiuchi K, Kasahara K, Kuroda Y, Morohoshi H, Hagiwara Y, Ishii G (Source: Journal of Asthma and Allergy)



[Perspective] The enigmatic tuft cell in immunity

Thu, 17 Mar 2016 21:34:05 +0100

Helminth and protozoan parasites are the most common infectious agents of humans living in developing countries and represent an important disease burden, particularly through their ability to cause physical and intellectual growth retardation in young children (1, 2). Type 2 immune responses promote efficient expulsion of intestinal parasites such as helminths by driving a “weep and sweep” response that involves mucous production, fluid secretion, and increased intestinal motility. These same responses in susceptible individuals cause the symptoms of allergy after exposure to pollens and certain food antigens. The generation of type 2 immunity in response to helminth parasites requires the secretion of cytokines by intestinal epithelial cells, but the source and induction of cytokine ...



FDA approves first generic form of oxiconazole nitrate cream

Thu, 17 Mar 2016 18:27:42 +0100

A generic formulation of oxiconazole nitrate cream, 1% has been approved by the Food and Drug Administration, for the treatment of tinea pedis, tinea cruris, tinea corporis due to Trichophyton... (Source: Skin and Allergy News)

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Sinonasal inverted papilloma: A case report and mini review of histopathological features.

Thu, 17 Mar 2016 17:22:01 +0100

In this study, we have presented a case report and reviewed the histological features of sinonasal inverted papilloma. PMID: 26980974 [PubMed] (Source: Journal of Oral and Maxillofacial Pathology)



Pharmacy Partnership Reduces Pediatric Asthma ReadmissionsPharmacy Partnership Reduces Pediatric Asthma Readmissions

Thu, 17 Mar 2016 17:19:45 +0100

Partnership with a local pharmacy to deliver medications to pediatric asthma patients upon discharge from a satellite facility lacking its own pharmacy was associated with reduced readmissions for asthma. Reuters Health Information (Source: Medscape Allergy Headlines)



Meta-Analysis Confirms 'Tennis Elbow' as Occupational Risk (CME/CE)

Thu, 17 Mar 2016 17:00:00 +0100

(MedPage Today) -- Repetitive strain doesn't just affect the wrist (Source: MedPage Today Allergy)



Allergan Confirms Generic Abraxane(R) Patent Challenge

Thu, 17 Mar 2016 16:44:24 +0100

DUBLIN, March 17, 2016 -- (Healthcare Sales & Marketing Network) -- Allergan plc (AGN), a leading global pharmaceutical company, today confirmed that it has filed an Abbreviated New Drug Application (ANDA) with the U.S. Food and Drug Administration (FDA) ... Biopharmaceuticals, Generics, FDAAllergan, Abraxane, Paclitaxel (Source: HSMN NewsFeed)



Obesity Tied to Higher Asthma Prevalence in WomenObesity Tied to Higher Asthma Prevalence in Women

Thu, 17 Mar 2016 10:10:55 +0100

The overall prevalence of asthma in US adults has also increased, federal health officials say. Medscape Medical News (Source: Medscape Allergy Headlines)

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Blog: Runny eggs and toast soldiers for infants?

Thu, 17 Mar 2016 09:00:00 +0100

Eggs are not recommended before six months due to the risk of allergy. However, some emerging research suggests that early introduction may be protective of egg allergy in infants, but more evidence is needed before changing the current recommendations Hide related content:  Show related content read more (Source: Nursing in Practice)



CAREONE ALL DAY ALLERGY D (Cetirizine Hcl, Pseudoephedrine Hcl) Tablet, Extended Release [American Sales Company]

Thu, 17 Mar 2016 05:00:00 +0100

Updated Date: Mar 17, 2016 EST (Source: DailyMed Drug Label Updates)



Antibodies from unconventional B cells less likely to neutralize HIV, NIH study finds

Thu, 17 Mar 2016 04:00:00 +0100

(NIH/National Institute of Allergy and Infectious Diseases) Antibodies derived from a type of immune cell found in unusually high numbers in HIV-infected individuals with chronically uncontrolled virus levels are less effective at neutralizing HIV than antibodies derived from a different type of immune cell more common in people without HIV, scientists report. The findings help explain why people infected with HIV cannot sufficiently clear the virus with effective antibodies. The study was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: EurekAlert! - Infectious and Emerging Diseases)



Practice of the Treatment of Milk Allergy in the UK: A National Audit

Thu, 17 Mar 2016 03:19:46 +0100

Conclusions: Current practice amongst UK clinicians of the management of CMA is broadly in line with current guidance, particularly the positioning of hypoallergenic milks as substitute milk choices. A notable deviation was the use of home baked milk challenges or re-introduction.Int Arch Allergy Immunol 2016;169:62-68 (Source: International Archives of Allergy and Immunology)



Evaluation of the immunogenicity of the 13-valent conjugated pneumococcal vaccine in rheumatoid arthritis patients treated with etanercept

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions In RA patients treated with ETA, vaccination with PCV13 is effective and safe, resulting in pAR one and two months after vaccination. Higher age at vaccination was identified as predictors of impaired pAR. The efficacy of vaccination may be more pronounced in younger RA patients. The vaccine is safe in RA patients on ETA. (Source: Joint Bone Spine)

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Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica™) in the treatment of naturally occurring flea and tick infestations in dogs presented as veterinary patients in Europe

Thu, 17 Mar 2016 00:00:00 +0100

Publication date: Available online 16 March 2016 Source:Veterinary Parasitology Author(s): Csilla Becskei, Filip De Bock, Joanna Illambas, Sean P. Mahabir, Robert Farkas, Robert H. Six Two randomised, blinded, multi-centered field studies were conducted in Europe to demonstrate the efficacy and safety of three monthly oral doses of sarolaner (Simparica™, Zoetis) administered at a minimum dosage of 2.0mg/kg (range 2–4mg/kg) against natural flea or tick infestation of dogs presented as veterinary patients. In the flea study, the improvement in clinical signs associated with flea allergy dermatitis (FAD) was also investigated. The palatability of the sarolaner chewable tablet formulation was evaluated in both studies. Spinosad (Comfortis® Chewable Tablets, Elanco) and fipronil (F...



In vitro tests for Drug Hypersensitivity Reactions. An ENDA/EAACI Drug Allergy Interest Group Position Paper

Thu, 17 Mar 2016 00:00:00 +0100

This article is protected by copyright. All rights reserved. (Source: Allergy)



The lipid‐interaction capacity of Sin a 2 and Ara h 1, major mustard and peanut allergens of the cupin superfamily, endorses allergenicity

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionSin a 2 and Ara h 1 interact with lipid components, which might well contribute to explain the potent allergenic capacity of these two clinically relevant allergens belonging to the cupin superfamily.This article is protected by copyright. All rights reserved. (Source: Allergy)



Mouth Breathing, another Risk Factor for Asthma: the Nagahama Study

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionMouth breathing may increase asthma morbidity, potentially through increased sensitization to inhaled allergens, which highlights the risk of mouth‐bypass breathing in the “one airway, one disease” concept. The risk of mouth breathing should be well recognized in subjects with allergic rhinitis and in the general population.This article is protected by copyright. All rights reserved. (Source: Allergy)



Application of extensively targeted next-generation sequencing for the diagnosis of primary immunodeficiencies

Thu, 17 Mar 2016 00:00:00 +0100

Primary immunodeficiencies (PIDs) represent a diverse group of inherited disorders caused by congenital defects of the immune system. The latest International Union of Immunological Societies classification has identified 240 causative genes, and more than 10 new genetic causes of PIDs have been described per year over recent years.1 A precise molecular diagnosis for patients with PIDs is critical for appropriate management, but a timely and accurate genetic diagnosis in daily clinical practice is difficult. (Source: Journal of Allergy and Clinical Immunology)

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The NPC2 protein

Thu, 17 Mar 2016 00:00:00 +0100

Dogs are an important source of indoor allergens that cause rhinoconjunctivitis, urticaria, and asthma in sensitized individuals. Can f 1 is reported as a major dog allergen, but other allergens have also been identified. Identification of immunologically important allergens is important for both the diagnosis and treatment of dog allergy. (Source: Annals of Allergy, Asthma and Immunology)



Interleukin‐9 and interleukin‐17C in chronic rhinosinusitis

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionInflammatory cell expression of IL‐9 and IL‐17C were increased in CRS, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of CRSwNP as well as atopy and may serve as therapeutic targets for disease management. (Source: International Forum of Allergy and Rhinology)



Placebo‐controlled assessment of somnolence effect of cetirizine: a meta‐analysis

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionThe meta‐analysis showed that the RDs between cetirizine 10 mg daily and placebo on somnolence rate were different for studies with and without a placebo run‐in period. The results for studies with a placebo run‐in period suggested that cetirizine 10 mg daily has no somnolence effect compared to placebo. (Source: International Forum of Allergy and Rhinology)



Human rhinovirus in experimental infection after peroral Lactobacillus rhamnosus GG consumption, a pilot study

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionResults did not show statistical differences in viral loads in subjects using L. rhamnosus GG when compared to placebo. HRV load positively correlated with the total symptom scores. (Source: International Forum of Allergy and Rhinology)



Evaluation of bacterial transmission to the paranasal sinuses through sinus irrigation

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionThe current study suggests that irrigation plays little role in establishing the sinus microbiome. Although rinsing with tap water may never be formally recommended, these data are useful to counsel patients who prefer to do so in non‐endemic areas if the municipal water supply is appropriately treated. (Source: International Forum of Allergy and Rhinology)

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Clinical implications of mucosal remodeling from chronic rhinosinusitis

Thu, 17 Mar 2016 00:00:00 +0100

ConclusionEstablished mucosal remodeling predicts a greater reliance on topical therapies to reach similar clinical endpoints as those without remodeling. (Source: International Forum of Allergy and Rhinology)



The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease

Thu, 17 Mar 2016 00:00:00 +0100

Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been sho...



Adverse histological features in malignant colorectal polyps: a contemporary series of 239 cases

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions Surgical resection should be recommended if ≥2 of these adverse histological features are present and may be warranted if one feature is present. A positive margin may require additional local resection but not necessarily surgery if no other adverse factors are present. (Source: Journal of Clinical Pathology)



Decreased expression of pSTAT, IRF-1 and DAP10 signalling molecules in peripheral blood lymphocytes of patients with metastatic melanoma

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions The altered signalling molecules of PBL could represent biomarkers of impaired cytotoxic and immunoregulatory function of these cells, indicating melanoma-associated immunosuppression that facilitates tumour progression. (Source: Journal of Clinical Pathology)



Differential diagnosis of bladder versus colorectal adenocarcinoma: keratin 7 and GATA3 positivity in nuclear ss-catenin-negative glandular tumours defines adenocarcinoma of the bladder

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions Differential diagnosis of BAC and CAC remains difficult, but positive staining for keratin 7 in nuclear ß-catenin-negative tumours argues for BAC. Additional markers like GATA3 and p63 may be added, as positivity in some cases may be helpful. However, for reliable histological diagnosis, knowledge of comprehensive clinical data is still essential. (Source: Journal of Clinical Pathology)

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Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions Elevated expression of ASCL2 may identify an aggressive subgroup in SCC and serve as an independent prognostic indicator in these patients. (Source: Journal of Clinical Pathology)



The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions In the current study, we demonstrate that high plasma fibrinogen levels at diagnosis predict poor outcome in patients with DLBCL. Trial registration number 25-434 ex 12713 and 415-EP/73/127-2012. (Source: Journal of Clinical Pathology)



Antiphospholipid syndrome presenting as cerebral venous sinus thrombosis: a case series and a review

Thu, 17 Mar 2016 00:00:00 +0100

In this report we will review the clinical and laboratory diagnostic criteria and the management of patients with antiphospholipid syndrome. (Source: Journal of Clinical Pathology)



An assessment of methods used in the investigation of iron status: findings in a population of young British South Asian children

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions Among 205 British South Asian children aged 4–43 months with high incidences of anaemia, iron deficiency, infection and α-thalassaemia, 151 (73.6%) were classified using haemoglobin, MCH, ferritin and CRP values. In 42 non-anaemic, iron-sufficient children with subnormal MCH values, that is with a phenotype of α-thalassaemia trait, RDW, %hypo and ZPP values did not differ significantly from those with iron-deficient erythropoiesis. Raised RDW, %hypo and ZPP values should be interpreted with caution in non-anaemic young British South Asian children with microcytosis. (Source: Journal of Clinical Pathology)



Method for identification of Cryptococcus neoformans and Cryptococcus gattii useful in resource-limited settings

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions The possibility of performing only a restriction digest makes the outlined method, similar to conventional techniques, economical and easy to optimise for routine use in resource-limited settings. (Source: Journal of Clinical Pathology)

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Breast carcinoma and phyllodes tumour: a case series

Thu, 17 Mar 2016 00:00:00 +0100

We report the clinicopathological characteristics of in situ and invasive carcinoma coexisting with PT in 10 patients treated in our institution over an 11-year period from 1992 to 2012. Ten patients with coexisting PT and in situ or invasive carcinoma were identified from our records. Six had carcinoma found within the PT. All were female with a median age of 47 (43–72) years. One patient had a history of PT in the same breast while another had a history of PT in the same breast as well as invasive ductal carcinoma in the contralateral breast. The rest did not have any risk factors of breast cancer. Five patients had a preoperative core needle biopsy performed with the report of a fibroepithelial lesion. The rest of the patients had surgery upfront for their breast masses. Two patie...



The duties of candour: what do they mean to paediatricians?

Thu, 17 Mar 2016 00:00:00 +0100

The duty of candour is a duty to be open and honest. New professional and statutory obligations have strengthened the requirement for candour for doctors and their organisations following the Mid Staffordshire Inquiry.In this article we explain what the new duties are for the practising paediatrician and the organisation. Although the new guidance may appear daunting, health professionals should be reassured that it intends to support and strengthen their professional practice and create a more open culture to improve transparency and patient care. What are the new duties and how did they come into being Doctors have always had a duty to be open and honest with their patients. However, when things go wrong, doctors haven't always been good at either disclosing facts or apologising to patie...



Dietary calcium intake influences the relationship between serum 25-hydroxyvitamin D3 (25OHD) concentration and parathyroid hormone (PTH) concentration

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions Dietary calcium intake modifies the relationship between serum 25OHD concentrations and intact serum PTH concentrations. Thus, dietary calcium intake should be taken into account when assessing an individual's vitamin D status. (Source: Archives of Disease in Childhood)



Frequency and aetiology of hypercalcaemia

Thu, 17 Mar 2016 00:00:00 +0100

Conclusions Sustained hypercalcaemia affects 1 in 500 children in a general hospital setting. The frequency was highest in neonates and underlying aetiology differed markedly with age. All children with sustained hypercalcaemia require thorough investigation to determine the underlying aetiology to ensure appropriate management. (Source: Archives of Disease in Childhood)



Influence of past breast feeding on pattern and severity of presentation of juvenile idiopathic arthritis

Thu, 17 Mar 2016 00:00:00 +0100

This analysis aimed to study the influence of breast feeding on the pattern and severity of juvenile idiopathic arthritis (JIA) at presentation. The association between ever versus never breast feeding and disease severity at onset was compared in 923 children with JIA recruited to the UK Childhood Arthritis Prospective Study at first presentation to rheumatology. Fifty six per cent of children were ever breast fed (median 3.7 months). Breastfed children reported a lower median age at onset, a lower Childhood Health Assessment Questionnaire (CHAQ), a measure of disease severity, lower parent general evaluation scores and lower pain at presentation. There was a trend towards a higher proportion of breastfed children with rheumatoid factor-negative polyarthritis, but lesser enthesitis-r...

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