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Preview: pubmed: H5N1 epidemiology

pubmed: H5N1 epidemiology



NCBI: db=pubmed; Term=H5N1 epidemiology



 



Serological evidence of H5-subtype influenza A virus infection in indigenous avian and mammalian species in Korea.
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Serological evidence of H5-subtype influenza A virus infection in indigenous avian and mammalian species in Korea.

Arch Virol. 2018 Mar;163(3):649-657

Authors: Kim HK, Kim HJ, Noh JY, Van Phan L, Kim JH, Song D, Na W, Kang A, Nguyen TL, Shin JH, Jeong DG, Yoon SW

Abstract
In Korea, H5-subtype highly pathogenic avian influenza (HPAI) has caused huge economic losses in poultry farms through outbreaks of H5N1 since 2003, H5N8 since 2013 and H5N6 since 2016. Although it was reported that long-distance migratory birds may play a major role in the global spread of avian influenza viruses (AIVs), transmission from such birds to poultry has not been confirmed. Intermediate hosts in the wild also may be a potential factor in viral transmission. Therefore, a total of 367 serum samples from wild animals were collected near major migratory bird habitats from 2011 to 2016 and tested by AIV-specific blocking ELISA and hemagglutination inhibition (HI) test. Two mammalian and eight avian species were seropositive according to the ELISA test. Among these, two mammalian (Hydropotes inermis and Prionailurus bengalensis) and three avian (Aegypius monachus, Cygnus cygnus, and Bubo bubo) species showed high HI titres (> 1,280) against one or two H5-subtype AIVs. As H. inermis (water deer), P. bengalensis (leopard cat), and B. bubo (Eurasian eagle owl) are indigenous animals in Korea, evidence of H5-subtype AIV in these animals implies that continuous monitoring of indigenous animals should be followed to understand interspecies transmission ecology of H5-subtype influenza viruses.

PMID: 29204739 [PubMed - indexed for MEDLINE]




Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015.
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Isolation and molecular characterization of an H5N1 swine influenza virus in China in 2015.

Arch Virol. 2018 Mar;163(3):701-705

Authors: Wu H, Yang F, Lu R, Xu L, Liu F, Peng X, Wu N

Abstract
In 2015, an H5N1 influenza virus was isolated from a pig in Zhejiang Province, Eastern China. This strain was characterized by whole-genome sequencing with subsequent phylogenetic analysis. Phylogenetic analysis showed that all segments from this strain belonged to clade 2.3.2 and that it had received its genes from poultry influenza viruses in China. A Glu627Lys mutation associated with pathogenicity was observed in the PB2 protein. This strain was moderately pathogenic in mice and was able to replicate without prior adaptation. These results suggest that active surveillance of swine influenza should be used as an early warning system for influenza outbreaks in mammals.

PMID: 29164401 [PubMed - indexed for MEDLINE]