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Preview: Journal of Medicinal Chemistry: Latest Articles (ACS Publications)

Journal of Medicinal Chemistry: Latest Articles (ACS Publications)



latest articles published in Journal of Medicinal Chemistry



Copyright: Copyright 2018 American Chemical Society
 



[ASAP] Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments

Fri, 20 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01745
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[ASAP] Combined Approach of Backbone Amide Linking and On-Resin N-Methylation for the Synthesis of Bioactive and Metabolically Stable Peptides

Fri, 20 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01809
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[ASAP] 18F-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management

Fri, 20 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00240
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[ASAP] Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis

Fri, 20 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00357
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[ASAP] N-Substituted Prodrugs of Mebendazole Provide Improved Aqueous Solubility and Oral Bioavailability in Mice and Dogs

Thu, 19 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01792
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[ASAP] An 18F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent

Thu, 19 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00138
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[ASAP] Synthetic Approaches to New Drugs Approved During 2016

Thu, 19 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00260
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[ASAP] Correction to Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors

Thu, 19 Apr 2018 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00579
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[ASAP] New Inhibitors of Breast Cancer Resistance Protein (ABCG2) Containing a 2,4-Disubstituted Pyridopyrimidine Scaffold

Wed, 18 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01012
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[ASAP] The Pharmacophore Network: A Computational Method for Exploring Structure–Activity Relationships from a Large Chemical Data Set

Wed, 18 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01890
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[ASAP] Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model

Wed, 18 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00232
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[ASAP] Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors

Tue, 17 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00035
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[ASAP] Lipophilic Efficiency as an Important Metric in Drug Design

Tue, 17 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00077
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[ASAP] Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)

Tue, 17 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00164
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[ASAP] Discovery of a Novel Small-Molecule Modulator of C–X–C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis

Tue, 17 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00190
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[ASAP] Design of Aminopeptidase N Inhibitors as Anti-cancer Agents

Mon, 16 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b00782
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[ASAP] Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5

Mon, 16 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00347
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[ASAP] Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin

Fri, 13 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01241
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[ASAP] Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity

Fri, 13 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01861
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[ASAP] Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors

Fri, 13 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01869
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[ASAP] Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor

Fri, 13 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00401
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[ASAP] Structure–Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3)

Thu, 12 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00336
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[ASAP] Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells

Wed, 11 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01694
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[ASAP] Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1

Wed, 11 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00170
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[ASAP] Toward ß-Secretase-1 Inhibitors with Improved Isoform Selectivity

Tue, 10 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01716
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[ASAP] Synthesis and Evaluation of Hydrogen Peroxide Sensitive Prodrugs of Methotrexate and Aminopterin for the Treatment of Rheumatoid Arthritis

Tue, 10 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01775
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[ASAP] Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain

Tue, 10 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01804
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[ASAP] Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Tue, 10 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01892
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[ASAP] Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria

Mon, 09 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01691
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[ASAP] Human ß-Defensin 1 and ß-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors

Mon, 09 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00251
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[ASAP] Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors

Fri, 06 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01593
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[ASAP] 2H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design

Fri, 06 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01870
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[ASAP] Synthesis and Structure–Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1H)-Pyridones

Thu, 05 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01256
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[ASAP] Antitubercular Bis-Substituted Cyclam Derivatives: Structure–Activity Relationships and in Vivo Studies

Thu, 05 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b01569
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[ASAP] Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins

Thu, 05 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00137
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[ASAP] Correction to “Atropisomer Control in Macrocyclic Factor VIIa Inhibitors”

Thu, 05 Apr 2018 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00465
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[ASAP] Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands

Wed, 04 Apr 2018 04:00:00 GMT

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00359
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[ASAP] BACE1: Now We Can See You

Wed, 04 Apr 2018 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.8b00474
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