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Preview: Chemical Research in Toxicology: Latest Articles (ACS Publications)

Chemical Research in Toxicology: Latest Articles (ACS Publications)



latest articles published in Chemical Research in Toxicology



Copyright: Copyright 2016 American Chemical Society
 



Development and Validation of a Computational Model for Androgen Receptor Activity

Fri, 09 Dec 2016 13:00:57 GMT2016-12-09T13:00:57Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00347
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Context Matters: Contribution of Specific DNA Adducts to the Genotoxic Properties of the Tobacco-Specific Nitrosamine NNK

Thu, 08 Dec 2016 13:20:20 GMT2016-12-08T13:20:20Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00386
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Advances in Structural and Single-Molecule Methods for Investigating DNA Lesion Bypass and Repair Polymerases

Thu, 08 Dec 2016 13:20:00 GMT2016-12-08T13:20:00Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00342
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Enolate-Forming Compounds as a Novel Approach to Cytoprotection

Tue, 06 Dec 2016 20:25:09 GMT2016-12-06T20:25:09Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00300
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Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Tue, 06 Dec 2016 16:59:14 GMT2016-12-06T16:59:14Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00384
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Drug–Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization

Mon, 05 Dec 2016 18:30:12 GMT2016-12-05T18:30:12Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00274
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21st Century Cell Culture for 21st Century Toxicology

Mon, 05 Dec 2016 13:42:35 GMT2016-12-05T13:42:35Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00269
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Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics

Mon, 05 Dec 2016 12:24:09 GMT2016-12-05T12:24:09Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00413
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Integrative “-Omics” Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis

Fri, 02 Dec 2016 20:48:09 GMT2016-12-02T20:48:09Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00337
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Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry

Fri, 02 Dec 2016 14:36:26 GMT2016-12-02T14:36:26Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00306
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Cysteine-Based Protein Adduction by Epoxide-Derived Metabolite(s) of Benzbromarone

Thu, 01 Dec 2016 05:27:01 GMT2016-12-01T05:27:01Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00275
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Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers

Thu, 01 Dec 2016 16:20:20 GMT2016-12-01T16:20:20Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00372
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Dynamic Phosphorylation of Apoptosis Signal Regulating Kinase 1 (ASK1) in Response to Oxidative and Electrophilic Stress

Wed, 30 Nov 2016 16:27:26 GMT2016-11-30T16:27:26Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00339
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Chemical Reactivity of Emodin and Its Oxidative Metabolites to Thiols

Wed, 30 Nov 2016 15:37:04 GMT2016-11-30T15:37:04Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00191
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A History of the Molecular Initiating Event

Wed, 30 Nov 2016 14:04:42 GMT2016-11-30T14:04:42Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00341
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Reaction Chemistry to Characterize the Molecular Initiating Event in Skin Sensitization: A Journey to Be Continued

Wed, 30 Nov 2016 14:03:47 GMT2016-11-30T14:03:47Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00365
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Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation

Mon, 28 Nov 2016 18:34:31 GMT2016-11-28T18:34:31Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00250
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Reactions of the Zn Proteome with Cd2+ and Other Xenobiotics: Trafficking and Toxicity

Mon, 28 Nov 2016 18:33:33 GMT2016-11-28T18:33:33Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00328
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2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes

Tue, 22 Nov 2016 05:49:22 GMT2016-11-22T05:49:22Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00371
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EPR Imaging Spin Probe Trityl Radical OX063: A Method for Its Isolation from Animal Effluent, Redox Chemistry of Its Quinone Methide Oxidation Product, and in Vivo Application in a Mouse

Tue, 22 Nov 2016 05:02:02 GMT2016-11-22T05:02:02Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00277
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Nicotine Metabolism and Smoking: Ethnic Differences in the Role of P450 2A6

Tue, 22 Nov 2016 14:12:01 GMT2016-11-22T14:12:01Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00387
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Stability and Application of Reactive Nitrogen and Oxygen Species-Induced Hemoglobin Modifications in Dry Blood Spots As Analyzed by Liquid Chromatography Tandem Mass Spectrometry

Mon, 21 Nov 2016 05:31:19 GMT2016-11-21T05:31:19Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00334
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Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone

Mon, 21 Nov 2016 05:31:01 GMT2016-11-21T05:31:01Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00369
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Pyrrolizidine Alkaloids: Metabolic Activation Pathways Leading to Liver Tumor Initiation

Mon, 21 Nov 2016 16:35:57 GMT2016-11-21T16:35:57Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00297
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No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury

Fri, 18 Nov 2016 05:36:58 GMT2016-11-18T05:36:58Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00400
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Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders

Thu, 17 Nov 2016 15:44:41 GMT2016-11-17T15:44:41Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00310
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For Better or Worse, Iron Overload by Superparamagnetic Iron Oxide Nanoparticles as a MRI Contrast Agent for Chronic Liver Diseases

Thu, 17 Nov 2016 12:18:50 GMT2016-11-17T12:18:50Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00298
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Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis

Wed, 16 Nov 2016 20:24:53 GMT2016-11-16T20:24:53Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00319
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New Approaches to Investigate Drug-Induced Hypersensitivity

Tue, 15 Nov 2016 12:09:58 GMT2016-11-15T12:09:58Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00333
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4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways

Fri, 11 Nov 2016 21:39:52 GMT2016-11-11T21:39:52Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00233
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Liabilities Associated with the Formation of “Hard” Electrophiles in Reactive Metabolite Trapping Screens

Thu, 10 Nov 2016 15:54:19 GMT2016-11-10T15:54:19Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00332
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Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict in Vivo Toxicity from in Vitro Data

Wed, 09 Nov 2016 12:45:52 GMT2016-11-09T12:45:52Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00302
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How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction

Tue, 08 Nov 2016 15:54:39 GMT2016-11-08T15:54:39Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00357
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Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage

Mon, 07 Nov 2016 15:14:57 GMT2016-11-07T15:14:57Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00265
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Toward the Design of Less Hazardous Chemicals: Exploring Comparative Oxidative Stress in Two Common Animal Models

Thu, 03 Nov 2016 15:01:03 GMT2016-11-03T15:01:03Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00246
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Carboxyethylpyrroles: From Hypothesis to the Discovery of Biologically Active Natural Products

Wed, 02 Nov 2016 15:24:35 GMT2016-11-02T15:24:35Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00304
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Understanding the Mutagenicity of O-Linked and C-Linked Guanine DNA Adducts: A Combined Experimental and Computational Approach

Tue, 01 Nov 2016 16:42:33 GMT2016-11-01T16:42:33Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00323
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Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases

Tue, 01 Nov 2016 15:35:43 GMT2016-11-01T15:35:43Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00285
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Omics Approaches To Probe Microbiota and Drug Metabolism Interactions

Wed, 26 Oct 2016 16:08:47 GMT2016-10-26T16:08:47Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00236
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Differences in Toxicological and Pharmacological Responses Mediated by Polymorphic Cytochromes P450 and Related Drug-Metabolizing Enzymes

Wed, 26 Oct 2016 13:22:23 GMT2016-10-26T13:22:23Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00286
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Advances in Predictive Toxicology for Discovery Safety through High Content Screening

Fri, 21 Oct 2016 11:48:49 GMT2016-10-21T11:48:49Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00248
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AGEs/RAGE-Related Neurodegeneration: daf-16 as a Mediator, Insulin as an Ameliorant, and C. elegans as an Expedient Research Model

Fri, 14 Oct 2016 13:59:59 GMT2016-10-14T13:59:59Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00264
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Computational Metabolomics: A Framework for the Million Metabolome

Wed, 12 Oct 2016 21:11:00 GMT2016-10-12T21:11:00Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00179
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Use of Accelerator Mass Spectrometry in Human Health and Molecular Toxicology

Tue, 11 Oct 2016 14:18:15 GMT2016-10-11T14:18:15Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00234
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Pesticide Chemical Research in Toxicology: Lessons from Nature

Fri, 07 Oct 2016 16:08:35 GMT2016-10-07T16:08:35Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00303
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Mass Spectrometric and Functional Aspects of Drug–Protein Conjugation

Fri, 30 Sep 2016 05:42:39 GMT2016-09-30T05:42:39Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00147
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Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects

Thu, 29 Sep 2016 16:10:21 GMT2016-09-29T16:10:21Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00256
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Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

Fri, 23 Sep 2016 19:28:12 GMT2016-09-23T19:28:12Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00150
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Combination of Metabolomics with Cellular Assays Reveals New Biomarkers and Mechanistic Insights on Xenoestrogenic Exposures in MCF-7 Cells

Mon, 29 Aug 2016 14:21:29 GMT2016-08-29T14:21:29Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00106
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Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions

Thu, 11 Aug 2016 14:20:01 GMT2016-08-11T14:20:01Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00226
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Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology

Tue, 05 Jul 2016 16:28:50 GMT2016-07-05T16:28:50Z

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Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.6b00136
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